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Rozprawy doktorskie na temat „Antifungal drus”

Autor: Grafiati

Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Lai, Yu-Wen. "Transcriptomic analysis of synergy between antifungal drugs and iron chelators for alternative antifungal therapies." Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/17064.

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There is an urgent need to improve the efficacy and range of antifungal drugs due to a global increase in invasive fungal infections, which are difficult to treat and are associated with high rates of mortality. Developing new drugs is expensive and time consuming and synergistic therapies that enhance the efficacy of current drugs are an alternative approach. Iron chelators have been used as antifungal synergents in salvage therapy, however, how these cause synergy are unknown. This thesis aims to use a transcriptomic approach to understand the mechanistic detail of antifungal-chelator synerg

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Sabzevari, Omid. "Azole antifungal drugs and cytochrome P450 induction." Thesis, University of Surrey, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359878.

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Venkateswarlu, Kanamarlapudi. "Azole antifungal drugs mode of action and resistance." Thesis, University of Sheffield, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389558.

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Barbosa, Mónica Rodrigues. "Evolution of antifungal drug resistance in Candida albicans." Master's thesis, Universidade de Aveiro, 2014. http://hdl.handle.net/10773/15332.

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Mestrado em Biologia Molecular e Celular<br>The human pathogen Candida albicans is characterized by the presence of a hybrid tRNA (tRNACAGSer) that can be aminoacylated by both LeuRS and SerRS. This tRNA is responsible for the ambiguity of the CUG codon that can be decoded as serine (97%) and Leucine (3%). Previous studies showed that the level of ambiguity is variable depending on the growth condition of the fungus. These studies also revealed that strains mistranslating at a higher level grew better in the presence of azoles, particularly in the presence of fluconazole. To analyse the effec

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5

Araújo, Ana Rita Dias. "Antifungal drug resistance driven by mistranslation in yeast." Master's thesis, Universidade de Aveiro, 2011. http://hdl.handle.net/10773/7942.

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Mestrado em Biotecnologia Molecular<br>Antifungal drug resistance has become a severe clinical problem and new targets for the development of new antifungal drugs need to be discovered. Ongoing work in our laboratory indicates that codon mistranslation due to codon ambiguity accelerates antifungal drug resistance in the human pathogen Candida albicans. The present work aimed to elucidate if non pathogenic yeasts behave similarly. Therefore, mistranslation was artificially induced in Saccharomyces cerevisiae strains by the expression of chimeric tRNAs. Each of the constructed strains car

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6

Dahal, Gopal Prasad. "Development of Selective Inhibitors against Enzymes Involved in the Aspartate Biosynthetic Pathway for Antifungal Drug Development." University of Toledo / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1532889045486984.

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Grice, Christopher Martin. "Peptide aptamer selection for antifungal drug discovery and diagnostics." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/51495.

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The demand for more effective fungal diagnostics and therapeutics is becoming increasingly urgent with increases in incidence of fungal diseases, antifungal resistance and lack of rapid diagnosis resulting in high mortality rates. The research described in this thesis evaluates the Aspergillus fumigatus pH-signalling receptor PalH (which non-redundantly regulates processing of the transcription factor PacC, and is essential for pathogenicity), as a viable therapeutic target. To assess intracellular modulation of PalH functionality, a novel proof-of-principle library of peptide aptamers (PAs),

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8

Vincent, Benjamin Matteson. "Exploiting fitness trade-offs to prevent antifungal drug resistance." Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/99573.

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Thesis: Ph. D. in Microbiology, Massachusetts Institute of Technology, Department of Biology, 2015.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references<br>The evolution of drug resistance in pathogenic microorganisms is typically viewed as an inevitable consequence of the selective pressures imposed by antimicrobial agents. However, although certain drugs rapidly lose efficacy in the clinic, others remain refractory to resistance. In my thesis, I tested the hypothesis that antifungal drug resistance is the outcome of diverse tradeoffs between the fitness benefits of

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9

Böttiger, Ylva. "Metabolic drug interactions in man : methodological aspects on in vivo studies /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4207-2/.

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10

Wetter, Tracy Jane. "Advances in yeast and mold monodrug and combination drug antifungal susceptibility testing." Diss., Montana State University, 2004. http://etd.lib.montana.edu/etd/2004/wetter/WetterT04.pdf.

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11

Siau, Hong. "The effects of antifungal drugs in combination on the growth of Candida species." Thesis, University of Cambridge, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359415.

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12

Johnson, E. M. "In vitro effects of antifungal drugs on Candida albicans and phagocytic cell function." Thesis, University of Bristol, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375031.

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13

Moreno, Velásquez Sergio. "The cellular and molecular responses of Aspergillus fumigatus to the antifungal drug caspofungin." Thesis, University of Manchester, 2018. https://www.research.manchester.ac.uk/portal/en/theses/the-cellular-and-molecular-responses-of-aspergillus-fumigatus-to-the-antifungal-drug-caspofungin(cf4638e8-6f50-455d-b9b3-2a27fab6da9b).html.

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The opportunistic fungus Aspergillus fumigatus has emerged as one of the most common fungal human pathogens, causing severe and usually fatal systemic infections that account for more than 200,000 cases annually with mortality rates usually exceeding 50%. During infection, the virulence of A. fumigatus highly depends on its capacity to rapidly respond to external stress encounters in the human niche, such as the host immunological response and the activity of antifungal drugs. The echinocandin, caspofungin, is one of most commonly used antifungal drugs to treat intolerant or refractive patient

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14

Abu-Elteen, Khalid Hussein. "Effect of sub-inhibitory concentrations of antifungal drugs on adherence of Candida species." Thesis, Loughborough University, 1991. https://dspace.lboro.ac.uk/2134/33210.

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The adherence of three Candida species to human buccal epithelial cells (BECs) following treatment of the yeast with sub-inhibitory concentrations of amphotericin B, nystatin, miconazole nitrate, 5-fluorocytosine, octenidine and pirtenidine was investigated in vitro. Pre-incubation of C. albicans (two strains), C. tropicalis or C.kefyr with these antifungal drugs inhibited their adherence to varying degrees (reduction between 17% and 78% of the control value). Pre-treatment of yeast for a short period (l hr) had less effect on adhesion than pre-treatment for a long period (24 hr). Furthermore,

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15

Palliyil, Biji. "The Preformulation and Formulation Development for Transungual Delivery of Antifungal Drug Ciclopirox olamine." Diss., Temple University Libraries, 2013. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/224325.

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Pharmaceutical Sciences<br>Ph.D.<br>Onychomycosis also known as dermatophytic onychomycosis is the fungal infection of the toenails and fingernails, characterized by discoloration and thickening of the nail and involves the nail plate, nail bed and nail folds. The disease is more than a cosmetic problem, as it severely impacts the patient's quality of life. Onychomycosis is an opportunistic infection in special subpopulations of patients suffering from diabetes, psoriasis, HIV/AIDS etc. The current treatment strategies involve systemic delivery of oral antifungal agents including azoles (e.g.

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Lance, Martin Richard. "Formulation and evaluation of novel amphotericin B oil/water triglyceride emulsions." Thesis, University of Nottingham, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338440.

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Ball, Lucy Margaret. "Antifungals and the trichophyton rubrum cell wall." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.670146.

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18

Li, Cong. "A PREFORMULATION DEVELOPMENT STUDY FOR THE TRANSUNGUAL DELIVERY OF THE ANTIFUNGAL DRUG ECONAZOLE NITRATE." Master's thesis, Temple University Libraries, 2013. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/241428.

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Pharmaceutical Sciences<br>M.S.<br>Onychomycosis is the most common disease of nails and constitutes about a half of all nail abnormalities. The thickness of the nails become the major challenge in developing a topical formulation for treatment on OM. In this study, penetration enhancers are used to enhance the solubility and permeability of the drug enconazole nitrate into the nail and the skin. It turns out of all the penetration enhancers, thiourea is the best choice because it can improve the solubility and nail penetration of econazole nitrate at the same time.<br>Temple University--These

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19

Silva, Hilris Rocha e. "Sistemas nanoestruturados estabilizados com álcool cetílico etoxilado e propoxilado contendo óleo de copaíba e fluconazol potencialmente ativo contra dermatomicoses /." Araraquara : [s.n.], 2011. http://hdl.handle.net/11449/102460.

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Resumo: Nas últimas décadas, tem ocorrido um aumento expressivo na incidência de infecções fúngicas. Por outro lado, o tratamento das micoses nem sempre é efetivo, pois os fármacos antifúngicos disponíveis apresentam espectro de atividade e perfil farmacocinético inadequados, em especial no tratamento das lesões cutâneas. Portanto, o objetivo do presente trabalho foi desenvolver e caracterizar sistemas nanoestruturados estabilizados com álcool cetílico etoxilado 20 OE e propoxilado 5 OP (PROC) contendo fluconazol (FLU), empregando ácido oléico (AO) e óleo de copaíba como fases oleosas. A carac

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20

Ellepola, Arjuna Nishantha Bandara. "The post-antifungal effect (PAFE) and its impact on the pathogenic attributes of Candida albicans." Thesis, Hong Kong : University of Hong Kong, 1999. http://sunzi.lib.hku.hk/hkuto/record.jsp?B21253274.

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Li, Cong. "The preformulation and formulation development for the transungual delivery of the antifungal drug econazole nitrate." Diss., Temple University Libraries, 2015. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/340105.

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Pharmaceutical Sciences<br>Ph.D.<br>Onychomycosis is fungal infection of toe nails or fingernails caused by a fungal microbe that invades the nail bed. It is the most common disease of the nails and constitutes about a half of all nail abnormalities and may affect toenails or fingernails, but toenail infections are particularly common. It occurs in about 10 percent of the adult population. The most common symptoms of fungal nail infection are thickening and discoloration of the nail. Treatment of onychomycosis is challenging because the infection is embedded in the nail making it difficult for

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Голубнича, Вікторія Миколаївна, Виктория Николаевна Голубничая, Viktoriia Mykolaivna Holubnycha, Ann Masko, and Inna Zakorko. "Evaluation of the sensetiviti candida spp. isolated from pregnant women and newborns to antifungal drugs." Thesis, Видавництво СумДУ, 2010. http://essuir.sumdu.edu.ua/handle/123456789/6774.

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Goughenour, Kristie. "Histoplasma capsulatum: Drugs and Sugars." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1584377509624302.

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Silva, Hilris Rocha e. [UNESP]. "Sistemas nanoestruturados estabilizados com álcool cetílico etoxilado e propoxilado contendo óleo de copaíba e fluconazol potencialmente ativo contra dermatomicoses." Universidade Estadual Paulista (UNESP), 2011. http://hdl.handle.net/11449/102460.

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Made available in DSpace on 2014-06-11T19:32:09Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-08-26Bitstream added on 2014-06-13T18:43:05Z : No. of bitstreams: 1 silva_hr_dr_arafcf.pdf: 2348065 bytes, checksum: c63f75a77b4cb78f5b87a6170be20a8f (MD5)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>Universidade Estadual Paulista (UNESP)<br>Nas últimas décadas, tem ocorrido um aumento expressivo na incidência de infecções fúngicas. Por outro lado, o tratamento das micoses nem sempre é efetivo, pois os fármacos antifúngicos disponíveis apresentam espectro de atividad

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25

Mohammadihashemi, Marjan. "Antibacterial and Antifungal Activity of Ceragenins, Mimics of Endogenous Antimicrobial Peptides." BYU ScholarsArchive, 2019. https://scholarsarchive.byu.edu/etd/7411.

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The continuous emergence of drug-resistance pathogens is a global concern. As a result, substantial effort is being expended to develop new therapeutics and mechanisms for controlling microbial growth to avoid entering a "post-antibiotic" era in which commonly used antibiotics are no longer effective in treating infections. In this work, we investigate the efficacy and application of ceragenins as non-peptide mimics of antimicrobial peptides (AMPs). First, this work examines the susceptibility of drug-resistant Gram-negative bacteria. The susceptibility of colistin-resistant clinical isolates

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26

Ghormade, V. "Dimorphism in benjaminiella poitrasii: a model system to study the morphogenesis and for screening antifungal drugs." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2000. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2288.

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vanzolini, tania. "Development of new biological drugs for the treatment of fungal infections." Doctoral thesis, Urbino, 2021. http://hdl.handle.net/11576/2692691.

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Mitra, Shuvadeep. "Characterization of the zinc cluster transcription factor Rds2 in «Saccharomyces cerevisiae» links glucose metabolism to antifungal drug resistance." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=103756.

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In Saccharomyces cerevisiae, zinc cluster proteins constitute the major family of transcriptional regulators for a variety of metabolic processes, yet the function of many are currently unknown. Previous studies have characterized Rds2 as a zinc cluster transcription factor that plays a role in antifungal drug resistance, but an exact mechanism is undefined. However, it has been established that Rds2 is a major regulator of gluconeogenesis. In this study, we aim to further mechanistically characterize the role of Rds2 in antifungal drug resistance. Microarray-based expression profiling of both

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Wang, Tao Verfasser], and Jeroen S. [Akademischer Betreuer] [Dickschat. "Discovery of antifungal and antibacterial volatile natural products and synthetic drug analogs / Tao Wang ; Betreuer: Jeroen S. Dickschat." Braunschweig : Technische Universität Braunschweig, 2018. http://d-nb.info/1175815454/34.

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Khundker, Sharmin. "Theory of solvation and its application to the supercritical fluid extraction/supercritical fluid chromatographic analysis of pharmaceuticals." Thesis, Northumbria University, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.245283.

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The roam objectives of this PhD project were to relate anal~ te solubility in supercritical carbon dioxide via molecular structure and also to investigate the factors that influence the solubility and extraction of analytes in a supercritical fluid extraction (SFE) when using carbon dioxide as the solvent. The polarity of an analyte was selected as the key parameter to developing a means of estimating steroid solubility in supercritical carbon dioxide. Polarity can be estimated by the hydrophobicity term, log P (based on partition coefficients), and also of the solubility parameter, 0,. The us

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Teixeira, Carlos Eduardo Cordeiro. "Efeito do farnesol sobre o fenÃtipo de resistÃncia e a produÃÃo de fosfolipase e protease em cepas de Candida spp." Universidade Federal do CearÃ, 2011. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=9555.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>Diversos sÃo os relatos de resistÃncia in vitro de cepas de Candida spp. a fÃrmacos antifÃngicos, em especial a derivados azÃlicos. Deste modo, a prospecÃÃo de novos compostos com propriedade antifÃngica se faz necessÃria. Assim, o objetivo deste estudo foi avaliar a atividade antifÃngica do sesquiterpeno farnesol, sua aÃÃo sinÃrgica com antifÃngicos fluconazol (FLC), itraconazol (ITC), voriconazol (VRZ), anfotericina B (AMB) e caspofungina (CASP), bem como avaliar sua aÃÃo sob a atividade enzimÃtica de fosfolipases e proteases,

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Slater, Joanne L. "Development of a Non-Mammalian Host to Investigate Virulence and Gene Expression of Aspergillus fumigatus and Efficacy of Antifungal Drugs." Thesis, University of Manchester, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.525916.

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Parfitt, Natalie Rae. "Investigations of the assessment of bioequivalence of topical clotrimazole products using a dermatopharmacokinetic approach." Thesis, Rhodes University, 2010. http://hdl.handle.net/10962/d1007659.

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The specialised nature of the stratum corneum makes it an efficient barrier to foreign substances, including drug molecules. Therefore, cutaneous drug absorption is a slow and complex process of which stratum corneum penetration is the rate limiting step. The rate and extent of stratum corneum penetration by a drug compound depends greatly on the presence of penetration enhancing/retarding excipients and therefore the clinical outcomes of a product rely greatly on the components and quality of the formulation. Hence, establishing bioequivalence between topical products is crucial to ensure tha

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Govender, Thashlin. "Antifungal activity of epithelia from selected frogs species of the south Western Cape of South Africa." Thesis, Cape Peninsula University of Technology, 2008. http://hdl.handle.net/20.500.11838/1476.

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Thesis (MTech Biomedical Technology)) ---Cape Peninsula University of Technology, 2008<br>Resistance to antibiotics has been acknowledged as a major global public health problem. The use of peptides to provide alternatives to combat multi drug resistant organisms is of current relevance to overcome antibiotic resistance. The high deversity of amphibian skin peptides render these animals a potential source for the discovery of novel drugs.

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Popp, Christina [Verfasser], Joachim [Gutachter] Morschhäuser, Wilma [Gutachter] Ziebuhr, and Frank [Gutachter] Ebel. "Evolution of antifungal drug resistance of the human-pathogenic fungus Candida albicans / Christina Popp ; Gutachter: Joachim Morschhäuser, Wilma Ziebuhr, Frank Ebel." Würzburg : Universität Würzburg, 2021. http://d-nb.info/1240614780/34.

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Маланюк, Х. В., та Н. В. Лофедрюк. "Вивчення протигрибкових властивостей похідних тіазолідонів". Thesis, Сумський державний університет, 2017. http://essuir.sumdu.edu.ua/handle/123456789/55093.

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В сучасному світі, і в Україні також, актуальною проблемою залишається захворюваність на грибкові інфекції. За останній час захворюваність мікозами різко підвищилась і характеризується тенденцією до ще більшого зростання. Причиною цього є прогресуюча резистентність грибів роду Candida до різноманітних протигрибкових лікарських засобів, які доволі часто використовуються нераціонально. Нові препарати повинні бути більш ефективними, ніж їх відомі аналоги. Пріоритетним у пошуку нових протигрибкових препаратів є вивчення впливів різних груп замісників на певні види протигрибкової активності.

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Abrantes, Pedro Miguel dos Santos. "Characterization of Candida species isolated from the oral mucosa of HIV-positive African patients." Thesis, UWC, 2013. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_2999_1398842890.

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<p>&nbsp<br></p> <p align="left">One of the most common HIV-associated opportunistic infections is candidiasis, caused by <i><font face="TimesNewRoman,Italic">Candida albicans </font></i><font lang="KO" face="TimesNewRoman">or other </font><i><font face="TimesNewRoman,Italic">Candida </font><font lang="KO" face="TimesNewRoman">species. In immune suppressed subjects, this commensal organism can cause an increase in patient morbidity and mortality due to oropharyngeal or systemic dissemination. Limited information exists on the prevalence and antifungal susceptibility of </font><i><font face="Ti

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Księżopolska, Ewa 1987. "Genomic changes driving the acquisition of multidrug resistance in Candida glabrata." Doctoral thesis, TDX (Tesis Doctorals en Xarxa), 2021. http://hdl.handle.net/10803/672386.

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This project was set out to broaden our knowledge of the processes driving the emergence of antifungal drug resistance in an opportunistic yeast pathogen Candida glabrata. More precisely, we sought to find the mutational signatures of drug resistance and cross-resistance to representatives of two clinically important antifungal drug classes, azoles and echinocandins. By combining in vitro evolution with phenotypic screening and comparative genomics analysis we investigated the relationship between genomic changes, fitness and drug susceptibility to shed light on the cellular mechanisms and evo

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Champleboux, Morgane. "Etude fonctionnelle et inhibition de la protéine Bdf1 chez Candida albicans." Thesis, Université Grenoble Alpes (ComUE), 2016. http://www.theses.fr/2016GREAV037.

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Candida albicans représente la première cause d’infection fongique chez l’Homme. Chez les patients immunodéficients, ce pathogène est extrêmement virulent et le nombre de décès suite à une infection systémique par Candida atteint 200 000 chaque année dans le monde. Quatre classes de médicaments antifongiques existent mais les traitements ont un coût élevé et des problèmes récurrents de résistance. Il y a donc un besoin urgent de trouver de nouvelles options thérapeutiques.Notre projet explore une nouvelle cible potentielle de la famille des protéines BET (Bromo and extra-terminal) pour traiter

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Valle, T. Figueras José María. "Variabilitat, efectivitat i seguretat del voriconazole en la infecció fúngica invasiva a pediatria." Doctoral thesis, Universitat Autònoma de Barcelona, 2020. http://hdl.handle.net/10803/670947.

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Introducció. Les concentracions plasmàtiques (CP) de voriconazole (VCZ) tenen una elevada variabilitat. El 2012 va canviar la posologia del VCZ a pediatria. Existeixen poques dades pediàtriques sobre el monitoratge de CP (MCP) de VCZ amb la dosificació actual. Es pretén avaluar el MCP i descriure la seva relació amb l’efectivitat i seguretat del tractament de la infecció fúngica invasiva (IFI) a pediatria amb la nova posologia. Mètodes. Estudi prospectiu observacional unicèntric, realitzat des de gener de 2014 fins agost de 2018 amb pacients de 2-12 anys en tractament amb VCZ a les dosis a

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Thomaz, Danilo Yamamoto. "Complexo Candida parapsilosis: identificação molecular das espécies, análise proteômica dos biofilmes por MALDI-TOF MS e investigação de um surto envolvendo isolados clínicos resistentes aos azólicos." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5133/tde-13022019-163819/.

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INTRODUÇÃO: A frequência de Candida parapsilosistem apresentado considerável aumento em UTIs neonatais. Embora a taxa de resistência dessa espécie aos azólicos seja baixa, recentemente têm sido relatados surtos de candidemia por isolados resistentes. A capacidade de adesão e formação de biofilme por essa espécie confere maior potencial patogênico e resistência aos antifúngicos. Portanto, a vigilância epidemiológica, tanto da resistência aos antifúngicos como da virulência dos isolados, é fundamental para o controle e prevenção das infecções e surtoshospitalares. A técnica de MALDI-TOF MS pode

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Silva, Paulo Mauricio Batista da. "Avaliação clínica e laboratorial do tratamento da estomatite protética através de produtos naturais." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/25/25135/tde-11112013-154447/.

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O aumento da resistência aos antifúngicos convencionais e os possíveis efeitos colaterais destes fármacos têm estimulado pesquisas sobre produtos naturais com potencial antimicrobiano e baixa toxicidade. Assim, o objetivo desta pesquisa foi realizar uma avaliação clínica e laboratorial do tratamento da estomatite protética (EP) através de produtos naturais, por meio de cultura micológica quantitativa, de microscopia confocal e de análise das propriedades superficiais de uma resina acrílica. Em todas as avaliações, os grupos experimentais foram divididos de acordo com as seguintes substâncias:

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Mathekga, Abbey Danny Matome. "Antimicrobial activity of Helichrysum species and the isolation of a new phloroglucinol from Helichrysum caespititium." Diss., Pretoria : [s.n.], 2001. http://upetd.up.ac.za/thesis/available/etd-04012003-141811.

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Vega, Chacón Yuliana del Pilar. "Susceptibilidade de Candida albicans resistente a fluconazol ao efeito fotodinâmica e inibidores dos sistemas de efluxo /." Araraquara, 2018. http://hdl.handle.net/11449/166350.

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Orientador: Ewerton Garcia de Oliveira Mima<br>Resumo: Um dos principais mecanismos de resistência microbiana são os sistemas de efluxo, que transportam medicamentos antimicrobiano para fora da célula. A eficácia de alguns agentes de inibição dos sistemas de efluxo tem sido reportada para reverter a resistência microbiana e também para potencializar as terapias antimicrobianas. Além disso, métodos alternativos aos agentes antimicrobianos convencionais têm sido investigados, como a Terapia Fotodinâmica antimicrobiana (aPDT). O objetivo desse estudo foi avaliar in vitro o efeito da aPDT e de doi

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Lopes, da Rosa-Spiegler Jessica. "Targeting the Histone Acetyl-Transferase, RTT109, for Novel Anti-Fungal Drug Development: A Dissertation." eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsbs_diss/624.

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Discovery of new antifungal chemo-therapeutics for humans is limited by the large degree of conservation among eukaryotic organisms. In recent years, the histone acetyl-transferase Rtt109 was identified as the sole enzyme responsible for an abundant and important histone modification, histone H3 lysine 56 (H3K56) acetylation. In the absence of Rtt109, the lack of acetylated H3K56 renders yeast cells extremely sensitive to genotoxic agents. Consequently, the ability to sustain genotoxic stress from the host immune system is crucial for pathogens to perpetuate an infection. Because Rtt109 is con

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Suñer, i. Carbó Joaquim. "Estudi galènic i biofarmacèutic d’emulsions múltiples de clotrimazol, econazol i bifonazol d’aplicació tòpica." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/404278.

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En el camp de la Indústria Farmacèutica és molt rellevant la innovació galènica que permeti al fàrmac alliberar-se d’una forma ràpida, eficaç i segura. En els últims anys, l’enfoc i avanç de la investigació farmacèutica en el camps dels sistemes dispersos, ha permès el desenvolupament de formulacions amb propietats fisicoquímiques i farmacològiques desitjades, les quals modifiquen de manera acusada el procés d’alliberació del fàrmac. Les emulsions múltiples d'aigua-en-oli-en-aigua (W/O/W) són sistemes dispersos de gran interès per la seva estructura i propietats, com a potencials sistemes

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Menezes, Ralciane de Paula. "Avaliação da frequência, atividade enzimática e sensibilidade a antifúngicos de leveduras do gênero Candida isoladas da cavidade bucal de pacientes portadores do HIV." Universidade Federal de Uberlândia, 2014. https://repositorio.ufu.br/handle/123456789/12798.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>The prevalence of Candida spp. as commensal of the oral cavity can reach 70%. However, oral cavity colonization not always culminates in oral candidiasis, however it can be considered a preliminary condition for the development of it. Oral candidiasis is the most common fungal infection among individuals with HIV, due the result of immune deficiency. Considering the importance of this type of infection in HIV-positive, we proposed to carry out this work with the following objectives: determine the frequency of HIV positive individu

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Bueid, Ahmed. "Laboratory epidemiology and mechanisms of azole resistance in Aspergillus fumigatus." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/laboratory-epidemiology-and-mechanisms-of-azole-resistance-in-aspergillus-fumigatus(cfaa6ee2-36d5-473c-9531-816d9578ff17).html.

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Although A. fumigatus strains are generally susceptible to azoles, recently, acquired resistance to a number of antifungal compounds has been reported, especially to triazoles possibly due to widespread clinical use of triazoles or through exposure to azole fungicides in the environment. The significant clinical problem of azole resistance has led to study the antifungal resistance mechanisms for developing effective therapeutic strategies. Of 230 clinical A. fumigatus isolates submitted during 2008 and 2009 to the Mycology Reference Centre Manchester, UK (MRCM), 64 (28%) were azole resistant

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Klein, Nazareth Magnago. "Ocorrência e suscetibilidade a drogas antifúngicas de Candida não-albicans, no Hospital Universitário Cassiano Antônio de Moraes, Vitória - ES." Universidade Federal do Espírito Santo, 2006. http://repositorio.ufes.br/handle/10/5892.

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Made available in DSpace on 2016-12-23T13:55:59Z (GMT). No. of bitstreams: 1 Dissertacao mestrado Nazareth Klein.pdf: 9490018 bytes, checksum: a860548b52d0cb66494dd6a26c4306df (MD5) Previous issue date: 2006-10-23<br>Este estudo foi conduzido para se avaliar a prevalência e a distribuição das espécies de Candida spp., isoladas de diversos materiais biológicos, obtidos de pacientes internados no Hospital Universitário Cassiano Antonio de Moraes (HUCAM), Vitória-ES, durante o período de janeiro de 2003 a dezembro 2005, e descrever o perfil de suscetibilidade de Candida não-albicans a drogas an

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Yousfi, Hanane. "Développement de nouvelles stratégies thérapeutiques pour pallier l'émergence de la résistance aux antifongiques." Thesis, Aix-Marseille, 2019. http://theses.univ-amu.fr.lama.univ-amu.fr/190704_YOUSFI_493ssh763uv119xcdly142ifq_TH.pdf.

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Les infections fongiques invasives constituent un sérieux problème de santé publique dans le monde ; cette situation se complique par la disponibilité d’un faible nombre d’antifongiques utilisés en pratique clinique. De ce fait,1280 molécules médicamenteuses, constituant la chimiothèque Prestwick, ont été testées sur des souches de champignons multirésistants d’intérêt clinique, isolées à l’Hôpital la Timone de Marseille. Le criblage primitif à une concentration de 10 µM avait permis l’identification de plusieurs molécules capables d’inhiber la croissance fongique.Par la suite, on s’est focali

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