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Artykuły w czasopismach na temat „Azienda Policlinico Umberto I”

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Data publikacji: 26 lipca 2024

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1

Scagnellato, L., A. Collesei, G. Cozzi, et al. "AB0944 COMORBIDITIES IN THE SPONDYLOARTHRITIS GISEA COHORT: AN AVERAGE TREATMENT EFFECT ANALYSIS ON PATIENTS TREATED WITH BDMARDS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1690.1–1690. http://dx.doi.org/10.1136/annrheumdis-2023-eular.2730.

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BackgroundThe treatment of Spondyloarthritis (SpA) has enormously improved thanks to bDMARDs, which are usually safe but they still require some caution because of their interference with the immune system homeostasis. ATE is a still evolving method designed to study the causal relationship between treatment and outcome.ObjectivesWe endeavoured to investigate the impact of TNF-inhibitors (TNFi), anti-interleukin17 or interleukin12/23 monoclonal antibodies (anti-IL) on comorbidities among SpA patients enrolled in the Italian GISEA Registry, using an average treatment effect (ATE) analysis.Metho

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Pucci, Resi, Andrea Cassoni, Daniele Di Carlo, et al. "Odontogenic-Related Head and Neck Infections: From Abscess to Mediastinitis: Our Experience, Limits, and Perspectives—A 5-Year Survey." International Journal of Environmental Research and Public Health 20, no. 4 (2023): 3469. http://dx.doi.org/10.3390/ijerph20043469.

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Background: Head and neck infections are commonly caused by affections with an odontogenic origin. Untreated or non-responsive to treatment odontogenic infections can cause severe consequences such as localized abscesses, deep neck infections (DNI), and mediastinitis, conditions where emergency procedures such as tracheostomy or cervicotomy could be needed. Methods: An epidemiological retrospective observational study was performed, and the objective of the investigation was to present a single-center 5-years retrospective analysis of all patients admitted to the emergency department of the ho

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3

Belsito, Angela, Dario Costa, Carmela Fiorito, et al. "Erythrocyte genotyping for transfusion-dependent patients at the Azienda Universitaria Policlinico of Naples." Transfusion and Apheresis Science 52, no. 1 (2015): 72–77. http://dx.doi.org/10.1016/j.transci.2014.12.006.

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Sterpetti, Antonio V., Antonino Cavallaro, Giorgio DeToma, and Sergio Stipa. "Francesco Durante and the hospital “Policlinico Umberto I”: The idea of a multidisciplinary university hospital." Surgery 155, no. 6 (2014): 1090–92. http://dx.doi.org/10.1016/j.surg.2014.01.019.

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Aceti, Franca, Francesca Aveni, Nicoletta Giacchetti, Paola Motta, and Bianca Straniero Sergio. "La depressione post-partum: inquadramento del problema." TERAPIA FAMILIARE, no. 94 (February 2011): 189–202. http://dx.doi.org/10.3280/tf2010-094013.

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In questo articolo gli Autori presentano i risultati preliminari relativi a 20 pazienti con diagnosi di depressione post-partum. Di recente infatti, č stato avviato dalla UOS di Igiene Mentale delle Relazioni Affettive e del post-partum del Policlinico Umberto I di Roma, un progetto intervento sui disturbi dell'umore nel puerperio. I dati raccolti finora indicano la prevalenza di un disturbo di personalitŕ del cluster B e che la depressione post-partum si configura come una difficoltŕ nel processo di separazione-individuazione madre-bambino che appare isomorfa a una indifferenziazione dei part

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Pesaresi, Cristiano, Giuseppe Migliara, Davide Pavia, and Corrado De Vito. "Emergency Department Overcrowding: A Retrospective Spatial Analysis and the Geocoding of Accesses. A Pilot Study in Rome." ISPRS International Journal of Geo-Information 9, no. 10 (2020): 579. http://dx.doi.org/10.3390/ijgi9100579.

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The overcrowding of first aid facilities creates considerable hardship and problems which have repercussions on patients’ wellbeing, the time needed for a diagnosis, and on the quality of the assistance. The basic objective of this contribution, based on the data collected by the Hospital Policlinico Umberto I in Rome (Lazio region, Italy), is to carry out a territorial screening of the municipality using GIS applications and spatial analyses aimed at reducing—in terms of triage—code white (inappropriate) attendances, after having identified the areas of greatest provenance of improperly used

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Brescini, Lucia, Filippo Della Martera, Gianluca Morroni, et al. "Use of Dalbavancin in Skin, Bone and Joint Infections: A Real-Life Experience in an Italian Center." Antibiotics 10, no. 9 (2021): 1129. http://dx.doi.org/10.3390/antibiotics10091129.

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Dalbavancin is a lipoglycopeptide approved for the treatment of acute bacterial skin and skin structure infections (ABSSSI). The aim of the study was to evaluate the efficacy and safety in all patients who received at least one administration of dalbavancin. Methods: We carried out a retrospective study of the use of dalbavancin in 55 patients at the Azienda Ospedaliera Ospedali Riuniti Umberto I (Ancona, Italy) from February 2017 to May 2020 and compared “on label” and “off label” use of dalbavancin in ABSSSI and non-ABSSSI. Results: A total of 55 patients were included in the study. The medi

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Lubrano Lavadera, Anna, Ludovica Iesu, and Anna Lisa Micci. "La rilevazione della IPV in diversi contesti clinici." MALTRATTAMENTO E ABUSO ALL'INFANZIA, no. 1 (May 2009): 43–61. http://dx.doi.org/10.3280/mal2009-001003.

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- The studies, conducted on the phenomenon of the Intimate Partner Violence (IPV), report the necessity to use a multidimensional approach which foresees the analysis of the risk and protection factors implicated. The present study is focused on the analysis of the formalities in which the phenomenon of the violence is investigated in different clinical contexts (social services, orders of family leaving, expert legal consultation, Department Alcoholics of the Policlinico Umberto I°, spanish anti-violence centre). For the data collection has been used a Scheme of analysis of histories of viole

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9

Minisola, Salvatore, Elisabetta Romagnoli, Liliana Scarnecchia, et al. "Serum carboxy-terminal propeptide of human type I procollagen in patients with primary hyperparathyroidism: studies in basal conditions and after parathyroid surgery." European Journal of Endocrinology 130, no. 6 (1994): 587–91. http://dx.doi.org/10.1530/eje.0.1300587.

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Minisola S, Romagnoli E, Scarnecchia L, Rosso R, Pacitti MT, Scarda A, Mazzuoli G. Serum carboxyterminal propeptide of human type I procollagen in patients with primary hyperparathyroidism: studies in basal conditions and after parathyroid surgery. Eur I Endocrinol 1994;130:587–91. ISSN 0804-4643 This study was carried out in order to evaluate serum carboxy-terminal propeptide of human type I procollagen (PICP) in patients with primary hyperparathyroidism and to examine its changes following parathyroidectomy. Seventeen patients (four males and 13 famels, aged 53.8 ± 3.1 sem years) were studie

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Ferrara, Francesco, Roberta Pasquinucci, Maurizio Capuozzo, et al. "Comparison and Analysis of Antibiotic Consumption in Two Italian Hospital Settings in Relation to the Fight of Antimicrobial Resistance." Pharmaceuticals 17, no. 2 (2024): 183. http://dx.doi.org/10.3390/ph17020183.

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Introduction: The emergence and spread of drug-resistant pathogens due to the improper use of antibiotics have become increasingly apparent in recent years. Objective: This retrospective comparative analysis aimed to assess and compare antibiotic prescription trends in Italy across two different regions based on geographic area and healthcare structure. One region represents a large hospital institution, while the other represents a populous local Italian health agency. The study also examined the impact of documented antibiotic stewardship programs and efforts to promote responsible antibioti

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11

De Felice, Francesca, Marco de Vincentiis, Valentino Valentini, et al. "Management of salivary gland malignant tumor: the Policlinico Umberto I, “Sapienza” University of Rome Head and Neck Unit clinical recommendations." Critical Reviews in Oncology/Hematology 120 (December 2017): 93–97. http://dx.doi.org/10.1016/j.critrevonc.2017.10.010.

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Colaprico, Corrado, Eleonora Ricci, Andrea Bongiovanni, et al. "Flu Vaccination among Healthcare Professionals in Times of COVID-19: Knowledge, Attitudes, and Behavior." Vaccines 10, no. 8 (2022): 1341. http://dx.doi.org/10.3390/vaccines10081341.

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The seasonal flu vaccine is the most important way to prevent influenza epidemics, so it is useful to increase the awareness of health professionals. The aim of our study is to evaluate knowledge, attitudes, and behavior about flu vaccination among healthcare professionals in times of COVID-19. Methods: A cross sectional study was carried out between November 2020 and April 2021. Participants were recruited in teaching hospital ‘Policlinico Umberto I’ of Rome. A survey of 24 questions about flu vaccination was administered, evaluating their knowledge, attitude, and practice about this topic. R

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13

Galli, Carlotta. "Odontogenic Abscesses during the Pandemic by SARS-CoV-2." Open Access Journal of Dental and Oral Surgery (OAJDOS) 3, no. 5 (2022): 1–5. http://dx.doi.org/10.54026/oajdos/1047.

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Dental abscess are pathologies caused by infectious processes in the teeth and/or their surrounding tissues. They can lead to complications, or in some cases they can be lethal, in base of the anatomy of the area of the oral cavity in which they develop. Therefore, this is a recurrent reason why patients with an odontogenic abscess may need to go to the dental emergency room. In this study, the access data to the emergency room of the “Policlinico Umberto I” of patients with odontogenic abscesses were analyzed and were put into a relation with the epidemic by SARS-CoV-2. The periods of 2019 an

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14

Zaccheo, Fabrizio, Andrea Cicconetti, Guido Gori, and Giulia Petroni. "Evaluating a Methodical Approach to Lingual Nerve Protection during Third Molar Surgery Using a Standardized Step-by-Step Procedure: A Retrospective Analysis." Applied Sciences 14, no. 13 (2024): 5835. http://dx.doi.org/10.3390/app14135835.

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The aim of this study was to assess the methodical protection of the lingual nerve via the use of a standardized step-by-step procedure in the surgical extraction of the lower third molar. A 5-year retrospective analysis of surgical third molar surgery conducted by third-year oral surgery specialty program students was performed in the oral surgery department of Policlinico Umberto I in Rome, from 2017 to 2022. All surgeries were carried out using a standardized step-by-step procedure to protect the lingual flap during the surgery. Every patient underwent a review on the initial postoperative

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15

La Torre, Giuseppe, Vanessa India Barletta, Mattia Marte, et al. "Assessment of Anxiety, Depression, Work-Related Stress, and Burnout in Health Care Workers (HCWs) Affected by COVID-19: Results of a Case–Control Study in Italy." Journal of Clinical Medicine 11, no. 15 (2022): 4434. http://dx.doi.org/10.3390/jcm11154434.

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This study aims to investigate whether HCWs infected with COVID-19 may experience potential psychological consequences and a higher incidence of depression, anxiety, work-related stress, and burnout compared to non-infected HCWs. A case–control study with 774 participants was conducted comparing COVID-19-infected HCWs (cases) and non-infected HCWs (controls) from the Occupational Medicine Unit at the Teaching Hospital Policlinico Umberto I, who were administered the same questionnaire including Hospital Anxiety and Depression Scale, Copenhagen Burnout Inventory and Karasek’s Job Content Questi

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Del Fante, Zoe, Nicola Di Fazio, Adriano Papale, et al. "Evaluation of Physical Risk during Necropsy and Morgue Activities as Risk Management Strategy." International Journal of Environmental Research and Public Health 18, no. 16 (2021): 8266. http://dx.doi.org/10.3390/ijerph18168266.

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Physical risk assessments allow us to understand work-related critical issues, thus representing a useful tool in risk management strategies. In particular, our study focuses on the identification of already known and emerging physical risks related to necropsy and morgue activities, as well as crime scene investigations. The aim of our study is, therefore, to identify objective elements in order to quantify exposure to such risk factors among healthcare professionals and working personnel. For the research of potentially at-risk activities, data from the Morgue of Policlinico Umberto I Hospit

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17

Bossù, Maurizio, Mario Trottini, Denise Corridore, et al. "Oral Health Status of Children with Autism in Central Italy." Applied Sciences 10, no. 7 (2020): 2247. http://dx.doi.org/10.3390/app10072247.

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Children with autism spectrum disorder (ASD) have significantly higher prevalence and caries severity compared to the average population. Knowledge about the oral health indices of children with this mental disorder is key to designing efficient plans of intervention. This paper reports the results of a study on the oral health status of children with ASD in central Italy. This is the first study of this type in Italy. The sample consists of 229 autistic children aged between 5 and 14 years, attending the Unit of Special Needs Policlinico Umberto I in Rome. Each patient received an intraoral e

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18

Triaca, Viviana, Elena Fico, Pamela Rosso, et al. "Pilot Investigation on p75ICD Expression in Laryngeal Squamous Cell Carcinoma." Cancers 14, no. 11 (2022): 2622. http://dx.doi.org/10.3390/cancers14112622.

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We investigated the p75 Neurotrophin Receptor (p75NTR) expression and cleavage product p75NTR Intracellular Domain (p75ICD) as potential oncogenic and metastatic markers in human Laryngeal Squamous Cell Carcinoma (LSCC). p75NTR is highly expressed in Cancer Stem Cells (CSCs) of the laryngeal epithelia and it has been proposed as a marker for stemness, cell migration, and chemo-resistance in different squamous carcinomas. To investigate the clinical significance of p75NTR cleavage products in solid tumors, full-length and cleaved p75NTR expression was analyzed in laryngeal primary tumors from d

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Tenuta, Marta, Alain Gelibter, Carla Pandozzi, et al. "Impact of Sarcopenia and Inflammation on Patients with Advanced Non-Small Cell Lung Cancer (NCSCL) Treated with Immune Checkpoint Inhibitors (ICIs): A Prospective Study." Cancers 13, no. 24 (2021): 6355. http://dx.doi.org/10.3390/cancers13246355.

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Background: Sarcopenia is a condition characterized by loss of skeletal muscle mass associated with worse clinical outcomes in cancer patients. Data on sarcopenia in patients undergoing immune checkpoint inhibitors (ICI) therapy are still limited. The aim of this prospective observational study was to investigate the relationship between sarcopenia, ICI treatment response and immunological profile, in patients with advanced non-small cell lung cancer (NSCLC). Methods: Forty-seven stage IV NSCLC patient candidates for starting ICI, were enrolled from the Policlinico Umberto I outpatient Oncolog

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Gratani, Loretta, Giacomo Puglielli, and Rosangela Catoni. "Relationship between Atmospheric CO<sub>2</sub> Concentration and Vegetation in a Hospital Area: The Policlinico Umberto I in Rome." American Journal of Plant Sciences 10, no. 08 (2019): 1313–24. http://dx.doi.org/10.4236/ajps.2019.108095.

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Terracina, Sergio, Antonio Pallaria, Marco Lucarelli, et al. "Urine Dipstick Analysis on Automated Platforms: Is a Reliable Screening Tool for Proteinuria? An Experience from Umberto I Hospital in Rome." Biomedicines 11, no. 4 (2023): 1174. http://dx.doi.org/10.3390/biomedicines11041174.

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Urinalysis is commonly used as a screening tool for kidney disease. In many cases, the dipstick urine assay includes the assessment of albumin/protein and creatinine; consequently, the value of their ratio is available on the urine section report. Identification of albuminuria/proteinuria at early stages is an important issue to prevent or at least delay the onset of chronic kidney disease (CKD), kidney failure, and the progression of cardiovascular damage linked to the kidney’s loss of function. Sensitive and specific diagnostic methods are required for the assessment of such an important bio

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Sampirisi, Luigi, Luca D’Angelo, Mauro Palmieri, Alessandro Pesce, and Antonio Santoro. "Extradural Clinoidectomy in Clinoidal Meningiomas: Analysis of the Surgical Technique and Evaluation of the Clinical Outcome." Tomography 8, no. 5 (2022): 2360–68. http://dx.doi.org/10.3390/tomography8050197.

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The surgical treatment of clinoidal meningiomas is currently still discussed in the literature. Different surgical approaches have been proposed and evaluated, in multiple studies, in order to improve the surgical outcomes. The aim of this study is to evaluate the advantages of extradural clinoidectomy in the context of tumor removal radicality for visual function improvement. A retrospective analysis was performed on 74 patients—of which 26 patients with clinoidal meningiomas were in group III, according to Al Mefty classification—who underwent surgery at the Policlinico Umberto I Hospital be

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De Angelis, Francesca, Stefania Basili, Fratto Giovanni, Pompiliu Dan Trifan, Stefano Di Carlo, and Licia Manzon. "Influence of the oral status on cardiovascular diseases in an older Italian population." International Journal of Immunopathology and Pharmacology 31 (January 1, 2018): 039463201775178. http://dx.doi.org/10.1177/0394632017751786.

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Oral diseases have been adversely associated with cardiovascular diseases (CVD), which are also the most frequent cause of death in older population. The aim of this study was to investigate the association among oral status indexes and CVD in patients aged more than 65 years attending in the Oral department of a public hospital Policlinico Umberto 1 of Rome. The study population consisted of 533 patients. Dental status was detected measuring the Decayed, Missing, and Filled Teeth (DMFT) and Community Periodontal Index (CPI) indexes. The chi-square test with a 95% confidence level was used to

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Marzuillo, Carolina, Maria De Giusti, Daniela Tufi, et al. "Molecular Characterization ofStenotrophomonas maltophiliaIsolates from Cystic Fibrosis Patients and the Hospital Environment." Infection Control & Hospital Epidemiology 30, no. 8 (2009): 753–58. http://dx.doi.org/10.1086/598683.

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Objectives.To ascertain whether cystic fibrosis (CF) patients are colonized or infected with unique or multiple strains ofStenotrophomonas maltophilia; to understand whether some strains colonize or infect more than 1 patient, indicating clonal spread; and to explore the molecular heterogeneity of hospital water isolates and their correlation with clinical isolates.Setting.The regional CF center of Policlinico “Umberto I” of Rome, Italy.Methods.The study was carried out on a random sample ofS. maltophiliaisolates (n= 110) collected from CF patients (n= 50) during the period 2002–2005 and on 24

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Accinni, Tommaso, Marianna Frascarelli, Antonino Buzzanca, et al. "S51. ANALYSIS OF SOCIAL COGNITION AS A PREDICTIVE FACTOR OF PSYCHOSIS IN 22Q11 DELETION SYNDROME (DS). DATA FROM THE MULTICENTER STUDY OF THE ITALIAN NETWORK FOR RESEARCH ON PSYCHOSES." Schizophrenia Bulletin 46, Supplement_1 (2020): S52. http://dx.doi.org/10.1093/schbul/sbaa031.117.

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Abstract Background 22q11DS is the most important genetic risk factor for schizophrenia: up to 28% of these subjects develop psychosis in adulthood. At present this syndrome represents the strongest biological model to investigate neurobiological underpinnings of schizophrenia. We expected Theory of Mind impairments in subjects at risk for psychosis (22q11DS) and more severe impairments in subjects with an established psychotic disorder. Furthermore we sought to investigate eventual correlations between social cognition and self-esteem levels, hypothesizing that both would be impaired in psych

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La Torre, Giuseppe, Gianluca Paglione, Lavinia Camilla Barone, et al. "Evaluation of the Factors Associated with Reinfections towards SARS-CoV-2 Using a Case Control Design." Journal of Clinical Medicine 12, no. 11 (2023): 3861. http://dx.doi.org/10.3390/jcm12113861.

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Objective: The risk of reinfection with SARS-CoV-2 has been rapidly increased with the circulation of concerns about variants. So, the aim of our study was to evaluate the factors that increase the risk of this reinfection in healthcare workers compared to those who have never been positive and those who have had only one positivity. Methods: A case-control study was carried out at the Teaching Hospital Policlinico Umberto I in Rome, Sapienza University of Rome, in the period between 6 March 2020 and 3 June 2022. Cases are healthcare workers who have developed a reinfection with the SARS-CoV-2

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Gholamalishahi, Shima, Seyed Ali Hosseini, Evaristo Ettorre, et al. "The Association between Levels of Physical Activity and Lifestyle, Life Expectancy, and Quality of Life in Patients with Alzheimer’s Disease." Journal of Clinical Medicine 12, no. 23 (2023): 7327. http://dx.doi.org/10.3390/jcm12237327.

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Background: Engaging in physical activity could help improve the quality of life in patients with Alzheimer’s disease. The objective of this study was to determine the association between the levels of physical activity and lifestyle, life expectancy, and quality of life in patients with Alzheimer’s disease in Iran and Italy. Methods: A total of 165 participants from Iran and Italy were enrolled in this cross-sectional study. In Iran, 85 patients participated in the study. In Italy, we enrolled 80 patients at the Sapienza University teaching hospital, Policlinico Umberto 1 in Rome. The inclusi

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Rusi, Eqrem, Fiorenza Pennacchia, Wael Abu Ruqa, et al. "Blood Count and Renal Functionality Assessments in the Emergency Section Disclose Morbidity and Mortality in Omicron COVID-19 Patients: A Retrospective Study." Clinics and Practice 14, no. 3 (2024): 685–702. http://dx.doi.org/10.3390/clinpract14030055.

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Background: SARS-CoV-2 is the coronavirus responsible for the COVID-19 pandemic. Even though we are no longer in a pandemic situation, people are still getting infected, some of them need hospitalization and a few of them die. Methods: We conducted a retrospective study including 445 patients who accessed the Emergency Section of Policlinico Umberto I, Rome, Italy, where they had routine blood exams. In this study, we focused on the complete blood count, serum creatinine and azotemia. The data were analyzed using ANOVA, Spearman correlation and ROC analyses. They were divided into four groups

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Letizia, Claudio, Marco Centanni, Luigi Scuro, et al. "High plasma levels of endothelin-1 in untreated Addison's disease." European Journal of Endocrinology 135, no. 6 (1996): 696–99. http://dx.doi.org/10.1530/eje.0.1350696.

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Letizia C, Centanni M, Scuro L, Canettieri G, Cerci S, De Ciocchis A, D'Ambrosio C, Scavo D. High plasma levels of endothelin 1 in untreated Addison's disease. Eur J Endocrinol 1996;135:696–9. ISSN 0804–4643 The aim of this study has been to investigate the plasma endothelin-1 (ET-1) levels in adult patients with proven Addison's disease (AD). Plasma ET-1 levels were measured in 29 subjects (17 males and 12 females, aged between 20 and 54 years): 15 of them were patients with AD and 14 were sex- and age-matched normal subjects, used as a control group. All patients with AD have been studied un

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Rossi, V., E. Viozzi, F. M. Nimbi, F. Tripodi, and M. G. Porpora. "Endometriosis and Infertility: Impact on Sexuality." Klinička psihologija 9, no. 1 (2016): 65. http://dx.doi.org/10.21465/2016-kp-op-0042.

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Objective: Endometriosis is a condition that has a great impact on women’s life. One of the most important consequences of the disease is infertility that may exacerbate the psychological, relational and sexual consequences on patients. The aim of the present study was to examine quality of life, anxiety, sexual functioning and relationship satisfaction of women with endometriosis and infertility. Infertility is supposed to be associated with a worse clinical profile. Design and Method: Data were collected on 71 patients (39 women with endometriosis and 32 with endometriosis and infertility) a

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Carlone, Luca, Marianna Frascarelli, Antonino Buzzanca, et al. "T219. REAL LIFE FUNCTIONING IN 22Q11 DELETION SYNDROME (DS) IN COMPARISON TO SCHIZOPHRENIA SUBJECTS: STUDY ON PSYCHOSES VULNERABILITY FACTORS. DATA FROM THE MULTICENTER STUDY OF THE ITALIAN NETWORK FOR RESEARCH ON PSYCHOSES." Schizophrenia Bulletin 46, Supplement_1 (2020): S316. http://dx.doi.org/10.1093/schbul/sbaa029.779.

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Abstract Background 22q11DS is the most common microdeletion with an incidence of 1:4000 live births. It is considered a genetic biological model for psychosis vulnerability: 25–28% of 22q11DS adults is affected by a psychotic disorder. Few data are available regarding functioning in 22q11DS. Our aim was to test the hypothesis that functioning is similar in 22q11DS psychotic and non-psychotic patients, and idiopathic schizophrenic subjects. We expected also a correlation between negative symptoms and functioning. Methods Data come from Italian Network for Research on Psychoses for the Schizoph

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Crudele, Lucilla, Fabio Novielli, Stefano Petruzzelli, et al. "Liver Fibrosis Indices Predict the Severity of SARS-CoV-2 Infection." Journal of Clinical Medicine 11, no. 18 (2022): 5369. http://dx.doi.org/10.3390/jcm11185369.

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Discovering novel risk and prognostic factors for COVID-19 may help not only in reducing severity and mortality but also in creating targeted therapies considering patients’ individual features. Liver fibrosis is considered a complication in Non-alcoholic Fatty Liver Disease (NAFLD), it is a feature of steatohepatitis (NASH), and it has already been related to an increased risk for a wide range of diseases. Here, we aimed to define if any parameter assessing metabolic status has predictive power in identifying inpatients at risk for poorer prognosis and an increased mortality from COVID-19. Th

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Brunetti, Antonio, Nicola Altini, Domenico Buongiorno, et al. "A Machine Learning and Radiomics Approach in Lung Cancer for Predicting Histological Subtype." Applied Sciences 12, no. 12 (2022): 5829. http://dx.doi.org/10.3390/app12125829.

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Lung cancer is one of the deadliest diseases worldwide. Computed Tomography (CT) images are a powerful tool for investigating the structure and texture of lung nodules. For a long time, trained radiologists have performed the grading and staging of cancer severity by relying on radiographic images. Recently, radiomics has been changing the traditional workflow for lung cancer staging by providing the technical and methodological means to analytically quantify lesions so that more accurate predictions could be performed while reducing the time required from each specialist to perform such tasks

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Graham, Neil Samuel Nyholm, Karl A. Zimmerman, Guido Bertolini, et al. "Multicentre longitudinal study of fluid and neuroimaging BIOmarkers of AXonal injury after traumatic brain injury: the BIO-AX-TBI study protocol." BMJ Open 10, no. 11 (2020): e042093. http://dx.doi.org/10.1136/bmjopen-2020-042093.

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Introduction and aimsTraumatic brain injury (TBI) often results in persistent disability, due particularly to cognitive impairments. Outcomes remain difficult to predict but appear to relate to axonal injury. Several new approaches involving fluid and neuroimaging biomarkers show promise to sensitively quantify axonal injury. By assessing these longitudinally in a large cohort, we aim both to improve our understanding of the pathophysiology of TBI, and provide better tools to predict clinical outcome.Methods and analysisBIOmarkers of AXonal injury after TBI is a prospective longitudinal study

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Oliva, Alessandra, Emanuele Rando, Dania Al Ismail, et al. "Role of Serum E-Selectin as a Biomarker of Infection Severity in Coronavirus Disease 2019." Journal of Clinical Medicine 10, no. 17 (2021): 4018. http://dx.doi.org/10.3390/jcm10174018.

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Introduction: E-selectin is a recognized marker of endothelial activation; however, its place in Coronavirus Disease 2019 (COVID-19) has not been fully explored. Aims of the study are to compare sE-selectin values among the Intensive Care Unit (ICU)-admitted and non-admitted, survived and non-survived patients and those with or without thrombosis. Methods: A single-center study of patients with COVID-19 hospitalized at Policlinico Umberto I (Rome) from March to May 2020 was performed. Simple and multiple logistic regression models were developed. Results: One hundred patients were included, wi

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Schiavi, Laura, Giulia Brindisi, Giovanna De Castro, et al. "Nasal reactivity evaluation in children with allergic rhinitis receiving grass pollen sublingual immunotherapy." Allergy and Asthma Proceedings 41, no. 5 (2020): 357–62. http://dx.doi.org/10.2500/aap.2020.41.200063.

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Background: The European Academy of Allergy and Clinical Immunology guidelines, strongly recommended allergen immunotherapy (AIT) as an effective treatment to achieve long-term clinical benefits and to modify the natural history of allergic diseases. Sublingual immunotherapy (SLIT) offers the possibility of home administration, which improves patient comfort and compliance. Objective: The primary outcome of this study was to assess the change in nasal reactivity after grass-pollen AIT treatment. Methods: This was a monocentric, prospective, observational study conducted in Rome from September

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Tiseo, Giusy, Elena Cavarretta, Arianna Forniti, et al. "Interplay between Nox2 Activity and Platelet Activation in Patients with Sepsis and Septic Shock: A Prospective Study." Oxidative Medicine and Cellular Longevity 2020 (October 27, 2020): 1–6. http://dx.doi.org/10.1155/2020/4165358.

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Background. Although preclinical studies highlighted the potential role of NADPH oxidase (NOX) in sepsis, only few studies evaluated the oxidative stress in patients with sepsis and septic shock. The objective of the study is to appraise the oxidative stress status and platelet function in patients with sepsis and septic shock compared to healthy controls. Methods and Results. Patients with sepsis or septic shock admitted to the hospital Policlinico Umberto I (Sapienza University, Rome) underwent a blood sample collection within 1 hour from admission. Platelet aggregation, serum thromboxane B2

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Micangeli, Ginevra, Roberto Paparella, Francesca Tarani, et al. "Clinical Management and Therapy of Precocious Puberty in the Sapienza University Pediatrics Hospital of Rome, Italy." Children 10, no. 10 (2023): 1672. http://dx.doi.org/10.3390/children10101672.

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Puberty identifies the transition from childhood to adulthood. Precocious puberty is the onset of signs of pubertal development before age eight in girls and before age nine in boys, it has an incidence of 1/5000–1/10,000 with an F:M ratio ranging from 3:1 to 20:1. Precocious puberty can be divided into central, also known as gonadotropin-dependent precocious puberty or true precocious puberty, and peripheral, also recognized as gonadotropin-independent precocious puberty or precocious pseudopuberty. Thus, the main aim of this narrative report is to describe the standard clinical management an

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Piovano, Elisa, Luca Fuso, Cinzia Baima Poma, et al. "Complications After the Treatment of Endometrial Cancer: A Prospective Study Using the French-Italian Glossary." International Journal of Gynecologic Cancer 24, no. 3 (2014): 418–26. http://dx.doi.org/10.1097/igc.0000000000000094.

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IntroductionThe evaluation of treatment complications is crucial in modern oncology because they heavily influence the every day life of patients. Several authors confirmed the reproducibility of the French-Italian glossary to score the complications in patients with endometrial cancer after radiotherapy (RT), but the treatment of endometrial carcinoma is primarily surgical and chemotherapy is often used for high-risk disease.ObjectivesThis study aimed to analyze the incidence of complications in our patients treated for endometrial cancer and to verify whether the glossary is a suitable instr

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Papalia, R. "AB0875 HYBRID COOPERATIVE COMPLEXES OF SODIUM HYALURONATE + SODIUM CHONDROITIN NON-SULFATED (HA-SC) IN THE TREATMENT OF HIP OA: CLINICAL RESULTS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1743.2–1744. http://dx.doi.org/10.1136/annrheumdis-2020-eular.4186.

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Background:Hip Osteoarthritis (OA) is a widespread disease characterized by pain and functional impairment, which, particularly in the elderly, may compromise overall health and quality of life. In the last decades, Intra-articular (I.a.) injections of hyaluronic acid (HA) gained more space among the conservative treatment of OA because of their beneficial effects and positive outcomes without relevant complications. (1,2). An innovative and patented formulation containing hybrid cooperative complexes of sodium hyaluronate 2.4% + sodium chondroitin non-sulfated 1.6% of biotechnological origin

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Ceci, Flavio Maria, Marco Fiore, Francesca Gavaruzzi, et al. "Early Routine Biomarkers of SARS-CoV-2 Morbidity and Mortality: Outcomes from an Emergency Section." Diagnostics 12, no. 1 (2022): 176. http://dx.doi.org/10.3390/diagnostics12010176.

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Background. COVID-19 is a severe acute respiratory disease caused by SARS-CoV-2, a virus belonging to the Coronaviridae family. This disease has spread rapidly around the world and soon became an international public health emergency leading to an unpredicted pressure on the hospital emergency units. Early routine blood biomarkers could be key predicting factors of COVID-19 morbidity and mortality as suggested for C-reactive protein (CRP), IL-6, prothrombin and D-dimer. This study aims to identify other early routine blood biomarkers for COVID-19 severity prediction disclosed directly into the

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Macrina, Francesco, Maria Cristina Acconcia, Luigi Tritapepe, et al. "Hypothermia during Surgical Treatment of Type A Aortic Dissection: A 16 Years’ Experience." International Journal of Vascular Medicine 2020 (January 25, 2020): 1–7. http://dx.doi.org/10.1155/2020/3893261.

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Acute aortic dissection (AAD) is among the most challenging cases for surgical treatment and requires procedural expertise for its safe conduct. Aortic surgery has undergone several changes over the last years, especially concerning cerebral protection. The brilliant results obtained with the aid of selective anterograde cerebral perfusion led to a progressive increase of circulatory arrest temperature, with the rise of safe time along with a reduction of the extracorporeal circulation time and hypothermia-related side effects. However, there is still no definitive consensus concerning the opt

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Musto, F., M. Ranalli, C. Giordano, et al. "P623 Mucosal eosinophils as markers of post-induction vedolizumab response in paediatric Ulcerative Colitis." Journal of Crohn's and Colitis 17, Supplement_1 (2023): i752—i753. http://dx.doi.org/10.1093/ecco-jcc/jjac190.0753.

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Abstract Background Vedolizumab (VDZ) is commonly used as an off-label therapy in children with ulcerative colitis (UC) but no predictive factors of response are available. Vedolizumab binds α4β7 integrin and blocks the migration of T-lymphocytes and other cells, including eosinophils, which are involved in the UC inflammatory process. The aim of our study was to explore the predictive value of pre-therapy mucosal eosinophil count on the response to vedolizumab induction therapy in a paediatric population with UC Methods This is a retrospective, monocentric study, including children with UC tr

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Santinelli, Letizia, Alessandro Lazzaro, Francesca Sciarra, et al. "Cellular Immune Profiling of Lung and Blood Compartments in Patients with SARS-CoV-2 Infection." Pathogens 12, no. 3 (2023): 442. http://dx.doi.org/10.3390/pathogens12030442.

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Background: SARS-CoV-2 related immunopathology may be the driving cause underlying severe COVID-19. Through an immunophenotyping analysis on paired bronchoalveolar lavage fluid (BALF) and blood samples collected from mechanically ventilated patients with COVID-19-associated Acute Respiratory Distress Syndrome (CARDS), this study aimed to evaluate the cellular immune responses in survivors and non-survivors of COVID-19. Methods: A total of 36 paired clinical samples of bronchoalveolar lavage fluid (BALF) mononuclear cells (BALF-MC) and peripheral blood mononuclear cells (PBMC) were collected fr

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La Torre, Giuseppe, Mattia Marte, Carlo Maria Previte, et al. "The Synergistic Effect of Time of Exposure, Distance and No Use of Personal Protective Equipment in the Determination of SARS-CoV-2 Infection: Results of a Contact Tracing Follow-Up Study in Healthcare Workers." International Journal of Environmental Research and Public Health 18, no. 18 (2021): 9456. http://dx.doi.org/10.3390/ijerph18189456.

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The aim of this study is to assess the effect of contact time, contact distance and the use of personal protective equipment on the determination of SARS-CoV-2 infection in healthcare workers (HCWs). This study consists of an analysis of data gathered for safety reasons at the Sapienza Teaching Hospital Policlinico Umberto I in Rome through the surveillance system that was put into place after the worsening of the COVID-19 pandemic. The studied subjects consist of HCWs who were put under health surveillance, i.e., all employees who were in contact with subjects who were confirmed to have teste

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Signore, Alberto, Marco Chianelli, Elisabetta Ferretti, et al. "New approach for in vivo detection of insulitis in type I diabetes: activated lymphocyte targeting with 123I-labelled interleukin 2." European Journal of Endocrinology 131, no. 4 (1994): 431–37. http://dx.doi.org/10.1530/eje.0.1310431.

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Signore A, Chianelli M, Ferretti E, Toscano A, Britton KE, Andreani D, Gale EAM, Pozzilli P. New approach for in vivo detection of insulitis in type I diabetes: activated lymphocyte targeting with 123I-labelled interleukin 2. Eur J Endocrinol 1994;131:431–7. ISSN 0804–4643 Insulitis is considered the histopathological hallmark of type I (insulin-dependent) diabetes. In the nonobese diabetic (NOD) mouse, diabetes has never been observed in the absence of insulitis. The in vivo detection of insulitis could be of relevance for early prediction of diabetes. As approximately 15% of islet-infiltrati

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Conticini, E., M. D’alessandro, S. Grazzini, et al. "POS1218 RELAPSES OF IDIOPATHIC INFLAMMATORY MYOPATHIES AFTER VACCINATION AGAINST COVID19: A REAL-LIFE ITALIAN STUDY." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 939. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1744.

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BackgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination plays a crucial role as pivotal strategies to curb the coronavirus disease-19 (COVID-19) pandemic. Despite the mass-scale vaccination, literature data about the incidence of disease flares in IIM patients are still not reported as well as the immunological condition.ObjectivesThe present study aimed to describe the clinical status of patients affected by IIM after vaccination against COVID19 in order to assess the number of relapses or immune-mediated reactions in a cohort of Italian patients with such disease.M

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Zaami, Simona, Rossella Melcarne, Renato Patrone, et al. "Oncofertility and Reproductive Counseling in Patients with Breast Cancer: A Retrospective Study." Journal of Clinical Medicine 11, no. 5 (2022): 1311. http://dx.doi.org/10.3390/jcm11051311.

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Introduction. Improving the prognosis of breast cancer patients is of utmost importance in terms of increasing survival rates. Modern medicine has therefore prioritized better quality of life for patients, even after the disease, through a better management of the potential long-term side effects induced by anticancer treatments. Fertility preservation and family planning are therefore crucial issues to be addressed in all cancer patients of reproductive age. Along those lines, a new branch of medicine with distinct multidisciplinary characteristics has developed over the years: oncofertility.

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Mancuso, S., S. Truglia, A. Capozzi, et al. "POS1238 ANTIPHOSPHOLIPID ANTIBODIES AND COVID-19: TREND OVER TIME." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 902.1–902. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3199.

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Background:Since the beginning of the SARS-CoV-2 outbreak, antiphospholipid antibodies (aPL), a known thrombotic risk factor, have been studied in COVID-19 patients, in whom thromboembolic events have been associated with poor prognosis. To date, the pathogenetic role of aPL and the trend over time is still unknown.Objectives:Aim of the study was to investigate whether aPL positivity was correlated with thrombosis in COVID-19 patients and whether it was a transient or persistent.Methods:We included all consecutive COVID-19 patients hospitalized at Policlinico Umberto I, Sapienza University of

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Musto, F., M. Distante, E. Dei Rossi, et al. "P556 Surgery in high-risk paediatric Crohn’s Disease treated with up-front anti-TNF agents and long-standing biologic therapy." Journal of Crohn's and Colitis 17, Supplement_1 (2023): i686—i687. http://dx.doi.org/10.1093/ecco-jcc/jjac190.0686.

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Abstract Background High-risk (HR) Crohn’s Disease (CD) is associated with high surgical and progression rates. Therefore, recent ESPGHAN guidelines (GL) suggest starting an early anti-TNFα treatment to modify the natural history of the disease. The aim of our study was to evaluate the surgical rate in a population of HR-CD paediatric patients treated with up-front anti-TNFα agents and long-standing biologic therapy Methods This is a retrospective, observational, single-center study conducted at the Paediatric Gastroenterology, Hepatology, and Endoscopy Unit at Policlinico Umberto I Hospital –

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