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Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Andree, Henricus Adrianus Maria. "Phospholipid binding and anticoagulant action of Annexin V." Maastricht : Maastricht : Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 1992. http://arno.unimaas.nl/show.cgi?fid=5692.

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2

Hong, Eui-ju. "Regulation of androgen action by sex hormone-binding globulin." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/35861.

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Sex hormone-binding globulin (SHBG) binds androgens and estrogens with high affinity, and regulates the distribution of these sex steroids in the blood and other biological fluids. Liver is the primary site of SHBG production, but the human SHBG transcription unit responsible for this is also expressed in proximal convoluted tubule (PCT) epithelial cells in a transgenic mouse model. Unlike hepatocytes which actively secrete SHBG and retain little immunoreactive SHBG within their cytoplasm, an incompletely glycosylated SHBG isoform has been found to accumulate inside PCT cells. These cells are

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3

Mongeau, Raymond. "Antidepressant and anxiolytic action on the Serotonin1A binding site." Thesis, McGill University, 1990. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=59934.

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Several lines of evidence suggest an involvement of serotonin$ sb{ rm 1A}$ (5-HT$ sb{ rm 1A}$ receptors in the regulation of emotions. In order to investigate the molecular basis of recent electrophysiological findings which implicated 5-HT$ sb{ rm 1A}$ receptors in the mechanism of action of antidepressants and anxiolytics, radioligand binding and autoradiographic studies using tritiated 8-hydroxy-2-(di-N-propylamino)-tetralin ( ($ sp3$H) -8-OH-DPAT) were done in rat brain following various treatments. These included: the tricyclic antidepressant imipramine; the reuptake blockers paroxetine a

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4

Duan, Xuchen. "Physiological and biological mechanisms of bisphosphonate action." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:36b0439d-2f89-4c1e-8bb3-941b4e6ee847.

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Bisphosphonates (BPs) are stable analogues of pyrophosphate widely used for the treatment of bone diseases characterised by increased bone resorption. Studies over the years have shown that the pharmacological potencies of BPs are dependent both on their binding affinities for bone mineral and on their inhibitory actions on osteoclasts. In addition, potential effects on other cell types present locally in the environment of skeletal tissues have been reported. The present study systematically evaluated the relative mineral-binding affinities of individual BPs of clinically relevance in mixture

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5

Williams, Maro R. I. 1974. "Dehydroepiandrosterone action in the cardiovascular system." Monash University, Dept. of Medicine, 2002. http://arrow.monash.edu.au/hdl/1959.1/7927.

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6

Robertson, Steven Ernest. "Receptor concentration affects glucocorticoid action." Thesis, Stellenbosch : University of Stellenbosch, 2011. http://hdl.handle.net/10019.1/6885.

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Thesis (PhD)--Stellenbosch University, 2011.<br>See also the post-print version of the article that was published from the PhD - http://hdl.handle.net/10019.1/19557<br>ENGLISH ABSTRACT: Glucocorticoid receptor (GR) levels, which modulate the response to glucocorticoids (GCs), vary between tissues and individuals and are altered by physiological and pharmacological effectors. In this study we set out to investigate the effects and implications of differences in GR concentration. Firstly, we established conditions that resulted in three statistically different GR populations in transiently t

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7

Bhosle, G. "Arginine-rich tat- and (R-X-R)-motif peptidomimetics for DNA/RNA binding, antimicrobial action and cell penetration." Thesis(Ph.D.), CSIR- National Chemical Laboratory, Pune, 2018. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/4545.

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8

Benyoucef, Samira. "IR/IGFR hybrids : tools for studying insulin and IGF-1 binding and action." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613706.

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9

Payne, Sarah Louise. "Structure function relationships and mechanisms of agonist action at the human Dâ†2â†(â†sâ†hâ†oâ†râ†tâ†) dopamine receptor." Thesis, University of Reading, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270213.

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10

Notenboom, Valerie. "Crystallographic studies of carbohydrate modifying proteins, mechanisms of action in polysaccharide binding and catalysis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0023/NQ49935.pdf.

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11

Drozd, Anja Christina. "Mechanisms of insulin-like growth factor binding protein-5 (IGFBP-5) action during myogenesis." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611613.

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12

Saidu, Dauda Kapu. "Studies on the mechanism of action and accumulation of structurally-distinct haeme-binding drugs." Thesis, University of Liverpool, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.430890.

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13

Muraro, Lucia. "Studies of Botulinum Neurotoxins Mechanism of Action." Doctoral thesis, Università degli studi di Padova, 2009. http://hdl.handle.net/11577/3425607.

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Botulinum neurotoxins (7 serotypes of BoNTs, named from A to G) and tetanus neurotoxin (TeNT) are the most powerful clostridial toxins (CNTs). They are responsible for botulism and tetanus respectively. TeNT and BoNTs bind to peripheral nerve terminals and inhibit neurotransmitter release from presynaptic neuronal cells by proteolytic cleavage of proteins involved in the fusion of synaptic vesicles with the cell membrane. BoNTs act at the level of Peripheral Nervous System (PNS) causing flaccid paralysis whereas TeNT acts at the level of Central Nervous System (CNS) causing spastic paralysis.

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14

Kaminishi, Tatsuya, Andreas Schedlbauer, Attilio Fabbretti, et al. "Crystallographic characterization of the ribosomal binding site and molecular mechanism of action of Hygromycin A." Oxford University Press, 2015. http://hdl.handle.net/10757/608247.

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Hygromycin A (HygA) binds to the large ribosomal subunit and inhibits its peptidyl transferase (PT) activity. The presented structural and biochemical data indicate that HygA does not interfere with the initial binding of aminoacyl-tRNA to the A site, but prevents its subsequent adjustment such that it fails to act as a substrate in the PT reaction. Structurally we demonstrate that HygA binds within the peptidyl transferase center (PTC) and induces a unique conformation. Specifically in its ribosomal binding site HygA would overlap and clash with aminoacyl-A76 ribose moiety and, therefore, its

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15

Vismer, Michael John. "An operational model for estrogenic action in the presence of sex hormone binding globulin (SHBG)." Thesis, Stellenbosch : Stellenbosch University, 2007. http://hdl.handle.net/10019.1/19887.

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Thesis (MSc)--University of Stellenbosch, 2007.<br>ENGLISH ABSTRACT: The aim of this study was to build a mathematical model that describes the binding of 17- -estradiol (E2) to estrogen receptor (ER- ) and the influence the sex hormone binding globulin (SHBG) has on this interaction. The influence of SHBG on the transactivation of an estrogen response element, via ligand bound ER- , was also studied. COS-1 cells, derived from the kidney of a green african monkey, were used to study the binding of E2 to ER- in the absence of SHBG. The influence of SHBG on the binding of E2 to ER- wa

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16

Holmes, Peter. "Structure and mode of action of the TolA-TolB complex from Pseudomonas aeruginosa." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:cccb0c88-5c89-4d21-81eb-70ebf513c7ab.

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Protein-protein interactions (PPIs) across the cell envelope of Gram-negative bacteria are critical for mediating signal transduction pathways that underpin cellular homeostasis. The Ton and Tol Pal systems are two conserved, ancestrally related protein networks that are also required for bacterial pathogenesis. Both Ton and Tol-Pal traverse the periplasm to effect different functions at the outer membrane (OM). Tol-Pal is composed of a homologous complex of three inner membrane proteins, TolQ-TolR-TolA (linked to proton motive force) and two additional periplasmic proteins TolB and Pal. The p

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17

Gunther, Erik Christian. "Molecular mechanisms of brain derived neurotrophic factor secretion and action /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/5086.

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18

Iwen, Alexander. "Molecular mechanisms of action of thyroid hormone the liver fatty acid binding protein as a model /." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972186670.

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19

Brandt, Valerie C. [Verfasser]. "Tics as event files. Perception-action binding in Gilles de la Tourette syndrome / Valerie C. Brandt." Lübeck : Zentrale Hochschulbibliothek Lübeck, 2015. http://d-nb.info/1077464193/34.

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20

Robertson, Johanna H. "Studies of the binding strengths and modes of action of organic ligands on aluminium trihydroxide surfaces." Thesis, University of Edinburgh, 2001. http://hdl.handle.net/1842/14308.

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This thesis describes work aimed at identifying new treatments for aluminium(oxide) surfaces which are based on complex formation at the interface by relatively simple organic ligands. Such an approach offers a more benign alternative to the surface roughening or passivation by strongly acidic and/or oxidising treatments which are currently used commercially. A specific objective of interest to the organisation sponsoring the work (Alcan) was the development of new dispersants for aluminium trihydroxide (ATH) which is used as a flame retardant in organic polymers. On the basis of reports of ea

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21

LIPARI, Elisa. "DEVELOPMENT AND QUALIFICATION OF BIOANALYTICAL METHODS FOR DEAMIDATED IFNβ-1a AND INVESTIGATION ABOUT THE MECHANISM OF ACTION". Doctoral thesis, Università degli Studi di Palermo, 2021. http://hdl.handle.net/10447/497430.

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Interferon beta-1a (IFNβ-1a) is a recombinant IFNβ with the tradename Rebif involved in several biological activities. Recently, it has been reported that artificial deamidation of IFNb-1a increases its biological response. Given the therapeutical potential, an investigation on the deamidated variant has been carried out via different approaches to discover the mechanism underlying this biological effect. The antiviral and immunomodulatory activity of deamidated cytokine was assessed using two precise and accurate cell-based assays. As expected, deamidated IFNβ-1a showed an increase in the bio

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22

Poon, Ming-see Angela. "Binding of 2[125I]iodomelatonin in the guinea pig spleen : evidence for a direct action of melatonin on the mammalian immune system /." [Hong Kong : University of Hong Kong], 1994. http://sunzi.lib.hku.hk/hkuto/record.jsp?B13705556.

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23

Saito, Naho. "Altered awareness of action in Parkinson’s disease: evaluations by explicit and implicit measures." Kyoto University, 2018. http://hdl.handle.net/2433/231008.

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24

Wolters, Eric. "Leges, Plebiscita, et Rogationes: Democratization and Legislative Action, 494 - 88 BC." Scholar Commons, 2014. https://scholarcommons.usf.edu/etd/5154.

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This study intends to analyze the importance of institutional trust in the process of democratization. In this particular case, the period from 494 to 88 BC in the Roman republic is examined. The theories of Charles Tilly and Robert Putnam are utilized to more deeply examine the concepts and manifestations of trust and democratization. Using the ideas and theories of these authors together provides a unique insight into the means by which a population comes to trust that government is responsive, and further comes to expect increased responsiveness in the future. Institutional trust as an elem

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25

Liang, Yizhi. "Study of The Mode of Action of Bacillus thuringiensis Delta- Endotoxin by Gene Manipulation and Binding Kinetics /." The Ohio State University, 1996. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487932351056975.

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26

Poon, Ming-see Angela, and 潘明施. "Binding of 2[125I]iodomelatonin in the guinea pig spleen: evidence for a direct action of melatonin on themammalian immune system." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1994. http://hub.hku.hk/bib/B31233855.

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27

Habibi, Javad. "Subcellular effects and localization of binding sites of Phytohemagglutinin in the potato leafhopper, Empoasca fabae (Harris) (Homoptera: Cicadellidae) /." free to MU campus, to others for purchase, 1996. http://wwwlib.umi.com/cr/mo/fullcit?p9737894.

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28

Lo, Susan Z. Y. "NF-kB- and mitochondria-linked signaling events that contribute to TNFa action in deferring physiological and chemotherapeutic drug-induced apoptosis in macrophages." University of Western Australia. School of Medicine and Pharmacology, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0095.

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TNF defers apoptosis in macrophages undergoing spontaneous or pharmacologically (thapsigargin, ceramide, CCCP, etoposide or cisplatin)-induced apoptosis, as determined by measurements of caspase-3 activity and annexin-V staining (Chapter 2). The action requires TNF interaction with TNF-R1, not TNF-R2. Survival is uniquely reliant on the activity of the NF-B signaling pathway, and does not require activities arising from the PI3K/Akt, JNK, ERK, p38 MAP kinase or iNOS pathways (Chapter 3). Further, the general anti-apoptotic property of TNF and its specific antagonism of CCCP-induced apoptosis l

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29

Weidenbach, Stevi. "INVESTIGATION OF THE MECHANISM OF ACTION FOR MITHRAMYCIN AND THE BIOSYNTHESIS OF L-REDNOSE IN SAQUAYAMYCINS." UKnowledge, 2017. http://uknowledge.uky.edu/pharmacy_etds/77.

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Natural products continue to be a major chemical lead matter for drug discovery due to their diverse chemical structures and bioactivities. Clinically significant natural products include anti-cancer and anti-infective compounds and while many more of these compounds show promising bioactivity, their clinical relevance is often limited by toxicity or poor solubility. Combinatorial biosynthesis can be employed to modify existing chemical scaffolds towards reducing these limitations. To fully take advantage of these biochemical tools, it is important to understand the biosynthesis and mechanism

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30

Kong, Weixi. "Oxidative DNA Damage and DNA Binding Induced by 2, 2-Bis (Bromomethyl)-1, 3-Propanediol: Possible Mode of Action Implicated in its Carcinogenicity." Diss., The University of Arizona, 2012. http://hdl.handle.net/10150/223375.

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The studies in this dissertation research were conducted to investigate the possible mode of action by which a brominated flame retardant, 2, 2-Bis (bromomethyl)-1, 3-propanediol (BMP) causes genotoxicity. Binding of BMP to DNA and BMP induced DNA strand breaks were investigated in SV-40 immortalized human uroepithelial cells (UROtsa) as an in vitro model for the bladder (a tissue that developed cancer after two year exposure to BMP in rodents). Results showed binding of [¹⁴C]-BMP equivalents to DNA increased with increased exposure time and concentration of [¹⁴C]-BMP. Comet analysis indicated

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31

Mulaudzi, Takalani. "An investigation of the zinc binding characteristics of the RING finger domain from the human RBBP6 protein using heteronuclear NMR spectroscopy." Thesis, University of the Western Cape, 2007. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_9063_1260173635.

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<p> <p>&nbsp<br></p> </p> <p align="left">Retinoblastoma binding protein 6 (RBBP6) is a 250 kDa human splicing-associated protein that is also known to interact with tumour suppressor proteins p53 and pRb and to mediate ubiquitination of p53 via its interaction with Hdm2. RBBP6 is highly up regulated in oesophageal cancer, and has been shown to be a promising target for immunotherapy against the disease. RBBP6 is also known to play a role in mRNA splicing, cell cycle control and apoptosis.</p>

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32

Cavazzana, Annachiara. "SENSE OF AGENCY AND INTENTIONAL BINDING: How does the brain link voluntary actions with their consequences?" Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3426771.

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The feeling of generating and controlling external effects through our own actions is known as Sense of Agency (SoAg). When we act we are generally in control of what we are doing and, therefore, we are aware and responsible for both our actions and their consequences. For many years, researchers have tried to identify appropriate measures to study the SoAg. It has often been investigated using explicit tasks in which participants verbally reported if they felt they were the authors of a certain effect. However, in our everyday life, we experience a continuous flow of actions and their effects

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33

Bortolozzi, Roberta. "Study of the mechanism of action of new molecules endowed with antitumoral activity." Doctoral thesis, Università degli studi di Padova, 2012. http://hdl.handle.net/11577/3422142.

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The microtubule system of eukaryotic cells is a critical element in a variety of fundamental cellular processes such as cell proliferation, mitotic spindle formation, maintenance of cell shape, regulation of motility, cell signaling, secretion, and intracellular transport. The important role of microtubules dynamic in mitosis progression and thus in cell proliferation, made them an attractive target for cancer therapy. Many chemically diverse compounds bind and affect tubulin-microtubule system, altering polymerization and dynamics during the particularly vulnerable mitotic stage of the cell c

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34

Fouquier, D´Hérouel Aymeric. "On diverse biophysical aspects of genetics : from the action of regulators to the characterization of transcripts." Doctoral thesis, KTH, Beräkningsbiologi, CB, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-31490.

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Genetics is among the most rewarding fields of biology for the theoretically inclined, offering both room and need for modeling approaches in the light of an abundance of experimental data of different kinds. Many aspects of the field are today understood in terms of physical and chemical models, joined by information theoretical descriptions. This thesis discusses different mechanisms and phenomena related to genetics, employing tools from statistical physics along with experimental biomolecular methods. Five articles support this work. Two articles deal with interactions between proteins and

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35

Bast, Darrin James. "Three biologically significant globotriasylceramide binding sites on the Verotoxin 1 B subunit, implications in toxin action, pathogenesis of disease and vaccine design." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ35106.pdf.

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36

Angara, Sureshbabu. "Novel cellular and molecular mechanisms of action of Insulin-like Growth Factor Binding Protein-5 (IGFBP-5) in human breast cancer cells." Thesis, University of Strathclyde, 2010. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=14471.

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37

Yateman, Martin Edward. "Regulation of human fibroblast insulin-like growth factor (IGF)-binding proteins by IGF-1 and cytokines, mechanisms of action and effects upon IGF bioactivity." Thesis, Queen Mary, University of London, 1995. http://qmro.qmul.ac.uk/xmlui/handle/123456789/1742.

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The insulin-like growth factors, IGF-I and IGF-II, are ubiquitous polypeptide molecules that have mitogenic and metabolic actions in a wide variety of cell types, and consequently play a major role in mammalian growth and development. Unlike many other peptide hormones, IGF levels and their bioactivity are highly dependent upon the secretion of a family of six specific binding proteins, named IGFBPs. In this thesis, we have developed a normal human fibroblast in vitro cell culture model to investigate both factors that affect IGFBP secretion, the mechanisms behind such regulation, and also the

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38

Barwe, Sonali P. "Studies On The Molecular Mechanism Of Cytokinin Action: Involvement Of Ca2+, Protein Kinase And Concurrent Protein Synthesis In Signaling Of Cytokinin-Induced Expression Of Pathogenesis-Related Enzymes In Cucumber." Thesis, Indian Institute of Science, 2000. https://etd.iisc.ac.in/handle/2005/178.

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Phytohormones act as signals to regulate plant growth and development by modulation of gene expression in response to internal developmental cues or external environmental stimuli, such as light and pathogen infection. There are five major classes of phytohormones, viz. auxins, cytokinins, gibberellins, ethylene and abscisic acid. Of these, cytokinins, 6N substituted adenine derivatives, are of special importance owing to their possible diverse roles in plant growth and development. They induce cell division, cell expansion in cotyledon, chloroplast and etioplast development, suppression of ap

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39

Barwe, Sonali P. "Studies On The Molecular Mechanism Of Cytokinin Action: Involvement Of Ca2+, Protein Kinase And Concurrent Protein Synthesis In Signaling Of Cytokinin-Induced Expression Of Pathogenesis-Related Enzymes In Cucumber." Thesis, Indian Institute of Science, 2000. http://hdl.handle.net/2005/178.

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Phytohormones act as signals to regulate plant growth and development by modulation of gene expression in response to internal developmental cues or external environmental stimuli, such as light and pathogen infection. There are five major classes of phytohormones, viz. auxins, cytokinins, gibberellins, ethylene and abscisic acid. Of these, cytokinins, 6N substituted adenine derivatives, are of special importance owing to their possible diverse roles in plant growth and development. They induce cell division, cell expansion in cotyledon, chloroplast and etioplast development, suppression of ap

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40

Kuhlman, Philip Alan. "Characterisation of the actin-binding site of α-actinin". Thesis, University of Leicester, 1993. http://hdl.handle.net/2381/35270.

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The alpha-actinin residues involved in the interaction of chicken smooth muscle alpha-actinin with F-actin were defined by co-sedimentation. Residues 120 to 140 of alpha-actinin were identified as essential with residues 141 to 159 and 1 to 107 contributing to the interaction. Temperature dependent binding and the lack of inhibition by high salt concentrations implicated hydrophobic interactions in the binding mechanism. Further characterisation of the binding interaction using stopped-flow techniques determined a K for the interaction of 0.82 muM at 15°C and 2.38 muM at 25°C. These techniques

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41

Corveleyn, Xavier. "Liage sensoriel par l’action : rôle des modèles internes et approche diagnostique dans le cadre de la maladie d’Alzheimer." Thesis, Lille 3, 2013. http://www.theses.fr/2013LIL30017/document.

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Si la perception de notre environnement paraît simple et naturelle, les attributs visuels composant les différents objets sont traités dans des espaces temps qui leur sont propres en engageant des voies neuronales distinctes. La question du liage des informations sensorielles en un percept unique est alors posée. Dans le cadre de cette thèse, la question du liage sensoriel a été étudiée au regard des actes moteurs volontaires. En situation d'observation passive, le point de simultanéité subjective (PSS) montre qu'un changement de couleur doit se produire 40 ms avant un changement de position p

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42

Bernard, Pascal. "Communication des organisations caritatives - Processus socio-cognitifs dans la production et la réception. Approches qualitative et expérimentale : processus socio-cognitifs dans la production et la réception : approches qualitative et expérimentale." Thesis, Aix-Marseille, 2015. http://www.theses.fr/2015AIXM5903.

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Régulièrement, les associations caritatives sollicitent financièrement des millions d’individus pour mener leurs actions sur le terrain. Représentant un enjeu majeur, ces campagnes de communication médiatique ont pour objectif d’appeler aux dons afin de collecter des fonds leur permettant de pérenniser leurs actions et de maintenir une indépendance à la fois financière et politique. Articulant une double méthodologie qualitative et expérimentale et l’aide d’un contexte théorique pluridisciplinaire mobilisant des ressources théoriques issues notamment des modèles psychosociaux de la réception,

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43

Romagnolo, Donato. "Autocrine mechanisms of action of insulin-like growth factor-I (IGF-I) and hormonal regulation of expression of IGF-finding proteins in mammary epithelial cells." Diss., This resource online, 1993. http://scholar.lib.vt.edu/theses/available/etd-06062008-171517/.

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44

Amato, Stephane. "Communications numérique engageante : relations entre théories, méthodologies et terrains." Thesis, Aix-Marseille, 2013. http://www.theses.fr/2013AIXM5902.

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Le travail doctoral concerne l’étude des dynamiques de changement en faveur de pratiques éco-citoyennes et liées à la mobilité via la communication numérique engageante. La question de recherche qui en découle relève de la définition des conditions et des modalités portant sur la possibilité de transposer les travaux fondateurs antérieurs consacrés à la communication engageante dans le cadre élargi d’interactions médiatées et médiatisées sur l’internet, en milieu naturel.Pour tenter de répondre à cette question, nous avons situé notre propos dans un cadre théorique et méthodologique ouvert en

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Wang, Hui. "Structural studies of actin and actin-binding proteins." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/10916.

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Actin is involved in cell movement, maintaining cell shape and anchoring cytoskeletal proteins. These functions are regulated by many actin-binding proteins, including those of the gelsolin superfamily. Gelsolin superfamily members regulate actin organization by severing, capping F-actin, nucleating the formation of F-actin and/or bundling F-actin. Although abundant structures are available for gelsolin and gelsolin fragments in complexes with actin, the detailed mechanisms for gelsolin activation, and for gelsolin severing and capping of F-actin are still unknown. Structures for gelsolin fami

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Hull, Richard Alan. "Actin and actin-binding proteins in higher plants." Thesis, University of Oxford, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.279874.

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MacPherson, Cameron Ross. "Transcriptional Regulatory Networks in the Mouse Hippocampus." Thesis, University of the Western Cape, 2007. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_1683_1259931126.

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<p> <p>&nbsp<br></p> </p> <p align="left">This study utilized large-scale gene expression data to define the regulatory networks of genes expressing in the hippocampus to which multiple disease pathologies may be associated. Specific aims were: ident i fy key regulatory transcription factors (TFs) responsible for observed gene expression patterns, reconstruct transcription regulatory networks, and prioritize likely TFs responsible for anatomically restricted gene expression. Most of the analysis was restricted to the CA3 sub-region of Ammon&rsquo<br>s horn within the hippocampus. We identified

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Adam, Muhammed Saleem. "A knowledgebase of stress reponsive gene regulatory elements in arabidopsis Thaliana." Thesis, University of the Western Cape, 2011. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_9599_1362393100.

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<p>Stress responsive genes play a key role in shaping the manner in which plants process and respond to environmental stress. Their gene products are linked to DNA transcription and its consequent translation into a response product. However, whilst these genes play a significant role in manufacturing responses to stressful stimuli, transcription factors coordinate access to these genes, specifically by accessing a gene&rsquo<br>s promoter region which houses transcription factor binding sites. Here transcriptional elements play a key role in mediating responses to environmental stress where e

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Scoville, Damon Charles. "Filament dynamics and actin binding factors." Diss., Restricted to subscribing institutions, 2008. http://proquest.umi.com/pqdweb?did=1693066541&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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Hsu, C. R. "Characterisation of a Salmonella actin-binding protein." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604683.

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<i>Salmonella</i> invasion protein C (SipC) and SipA bind actin directly. SipC inserts into the host cell plasma membrane from where it promotes effector delivery and is essential for <i>Salmonella</i> invasion. SipC-C (residues 200-409) directly nucleates actin polymerisation <i>in vitro</i> and induces cytoskeletal rearrangements at the leading edge when expressed in cells. By analysis a panel of SipC-C derivatives in transfected cells, a region spanning residues 377-409 was defined as necessary for actin reorganisation and leading-edge localisation. Residues 377-409 were sufficient to local

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