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Artykuły w czasopismach na temat „Binding action”

Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Kirsch, Wladimir, Roland Pfister, and Wilfried Kunde. "Spatial action-effect binding." Attention, Perception, & Psychophysics 78, no. 1 (2015): 133–42. http://dx.doi.org/10.3758/s13414-015-0997-z.

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Schwarz, Katharina A., Lisa Weller, Roland Pfister, and Wilfried Kunde. "Connecting action control and agency: Does action-effect binding affect temporal binding?" Consciousness and Cognition 76 (November 2019): 102833. http://dx.doi.org/10.1016/j.concog.2019.102833.

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Di Costa, Steven, Héloïse Théro, Valérian Chambon, and Patrick Haggard. "Try and try again: Post-error boost of an implicit measure of agency." Quarterly Journal of Experimental Psychology 71, no. 7 (2018): 1584–95. http://dx.doi.org/10.1080/17470218.2017.1350871.

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The sense of agency refers to the feeling that we control our actions and, through them, effects in the outside world. Reinforcement learning provides an important theoretical framework for understanding why people choose to make particular actions. Few previous studies have considered how reinforcement and learning might influence the subjective experience of agency over actions and outcomes. In two experiments, participants chose between two action alternatives, which differed in reward probability. Occasional reversals of action–reward mapping required participants to monitor outcomes and a

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4

Diedrichsen, Jörn, and Eliot Hazeltine. "Unifying by binding: Will binding really bind?" Behavioral and Brain Sciences 24, no. 5 (2001): 884–85. http://dx.doi.org/10.1017/s0140525x01260105.

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The theory of event coding by Hommel et al. proposes that feature binding is a central component of action planning. To evaluate the binding hypothesis, we consider findings from studies of action-perception interference and bimanual movements. We argue that although binding of action features may be a valuable concept, interference from partial feature overlap does not provide a parsimonious account for the observed phenomena.

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5

Mocke, Viola, Lisa Weller, Christian Frings, Klaus Rothermund, and Wilfried Kunde. "Task relevance determines binding of effect features in action planning." Attention, Perception, & Psychophysics 82, no. 8 (2020): 3811–31. http://dx.doi.org/10.3758/s13414-020-02123-x.

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Abstract Action planning can be construed as the temporary binding of features of perceptual action effects. While previous research demonstrated binding for task-relevant, body-related effect features, the role of task-irrelevant or environment-related effect features in action planning is less clear. Here, we studied whether task-relevance or body-relatedness determines feature binding in action planning. Participants planned an action A, but before executing it initiated an intermediate action B. Each action relied on a body-related effect feature (index vs. middle finger movement) and an e

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6

Buehner, Marc J. "Understanding the Past, Predicting the Future." Psychological Science 23, no. 12 (2012): 1490–97. http://dx.doi.org/10.1177/0956797612444612.

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Temporal binding refers to a subjective shortening of elapsed time between actions and their resultant consequences. Originally, it was thought that temporal binding is specific to motor learning and arises as a consequence of either sensory adaptation or the associative principles of the forward model of motor command. Both of these interpretations assume that the binding effect is rooted in the motor system and, critically, that it is driven by intentional action planning. The research reported here demonstrates that both intentional actions and mechanical causes result in temporal binding,

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7

Binetti, N., N. Hagura, C. Fadipe, A. Tomassini, V. Walsh, and S. Bestmann. "Binding space and time through action." Proceedings of the Royal Society B: Biological Sciences 282, no. 1805 (2015): 20150381. http://dx.doi.org/10.1098/rspb.2015.0381.

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Space and time are intimately coupled dimensions in the human brain. Several lines of evidence suggest that space and time are processed by a shared analogue magnitude system. It has been proposed that actions are instrumental in establishing this shared magnitude system. Here we provide evidence in support of this hypothesis, by showing that the interaction between space and time is enhanced when magnitude information is acquired through action. Participants observed increases or decreases in the height of a visual bar (spatial magnitude) while judging whether a simultaneously presented seque

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8

Lush, Peter, Emilie A. Caspar, Axel Cleeremans, Patrick Haggard, Pedro Alexandre Magalhães De Saldanha da Gama, and Zoltan Dienes. "The Power of Suggestion: Posthypnotically Induced Changes in the Temporal Binding of Intentional Action Outcomes." Psychological Science 28, no. 5 (2017): 661–69. http://dx.doi.org/10.1177/0956797616687015.

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The sense of agency is the experience of initiating and controlling one’s voluntary actions and their outcomes. Intentional binding (i.e., when voluntary actions and their outcomes are perceived to occur closer together in time than involuntary actions and their outcomes) is increased in intentional action but requires no explicit reflection on agency. The reported experience of involuntariness is central to hypnotic responding, during which strategic action is experienced as involuntary. We report reduced intentional binding in a hypnotically induced experience of involuntariness, providing a

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9

Eder, Andreas B., Thorsten M. Erle, and Wilfried Kunde. "Reward strengthens action–effect binding." Motivation Science 6, no. 3 (2020): 297–302. http://dx.doi.org/10.1037/mot0000153.

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10

Suzuki, Keisuke, Peter Lush, Anil K. Seth, and Warrick Roseboom. "Intentional Binding Without Intentional Action." Psychological Science 30, no. 6 (2019): 842–53. http://dx.doi.org/10.1177/0956797619842191.

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The experience of authorship over one’s actions and their consequences—sense of agency—is a fundamental aspect of conscious experience. In recent years, it has become common to use intentional binding as an implicit measure of the sense of agency. However, it remains contentious whether reported intentional-binding effects indicate the role of intention-related information in perception or merely represent a strong case of multisensory causal binding. Here, we used a novel virtual-reality setup to demonstrate identical magnitude-binding effects in both the presence and complete absence of inte

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11

Nattkemper, Dieter, Michael Ziessler, and Peter A. Frensch. "Binding in voluntary action control." Neuroscience & Biobehavioral Reviews 34, no. 7 (2010): 1092–101. http://dx.doi.org/10.1016/j.neubiorev.2009.12.013.

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12

Schwarz, Katharina A., Sebastian Burger, David Dignath, Wilfried Kunde, and Roland Pfister. "Action-effect binding and agency." Consciousness and Cognition 65 (October 2018): 304–9. http://dx.doi.org/10.1016/j.concog.2018.10.001.

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13

Tanaka, Takumi, Takuya Matsumoto, Shintaro Hayashi, Shiro Takagi, and Hideaki Kawabata. "What Makes Action and Outcome Temporally Close to Each Other: A Systematic Review and Meta-Analysis of Temporal Binding." Timing & Time Perception 7, no. 3 (2019): 189–218. http://dx.doi.org/10.1163/22134468-20191150.

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Temporal binding refers to the subjective compression of the temporal interval between a voluntary action and its external sensory consequences. While empirical evidence and theoretical accounts have indicated the potential linkage between temporal binding and action outcome prediction mechanisms, several questions regarding the underlying processes and the fundamental nature of temporal binding remain unanswered. Based on the sophisticated classification of predictive processes proposed by Hughes et al. (2013), we conducted a systematic, quantitative review of the binding effect as measured w

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14

Kleimaker, Maximilian, Adam Takacs, Giulia Conte, et al. "Increased perception-action binding in Tourette syndrome." Brain 143, no. 6 (2020): 1934–45. http://dx.doi.org/10.1093/brain/awaa111.

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Abstract Gilles de la Tourette syndrome is a multifaceted neurodevelopmental disorder characterized by multiple motor and vocal tics. Research in Tourette syndrome has traditionally focused on the motor system. However, there is increasing evidence that perceptual and cognitive processes play a crucial role as well. Against this background it has been reasoned that processes linking perception and action might be particularly affected in these patients with the strength of perception-action binding being increased. However, this has not yet been studied experimentally. Here, we investigated ad

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15

Jégou, Antoine, and Guillaume Romet-Lemonne. "Mechanically tuning actin filaments to modulate the action of actin-binding proteins." Current Opinion in Cell Biology 68 (February 2021): 72–80. http://dx.doi.org/10.1016/j.ceb.2020.09.002.

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16

Antusch, S., R. Custers, H. Marien, and H. Aarts. "Studying the sense of agency in the absence of motor movement: an investigation into temporal binding of tactile sensations and auditory effects." Experimental Brain Research 239, no. 6 (2021): 1795–806. http://dx.doi.org/10.1007/s00221-021-06087-8.

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AbstractPeople form coherent representations of goal-directed actions. Such agency experiences of intentional action are reflected by a shift in temporal perception: self-generated motor movements and subsequent sensory effects are perceived to occur closer together in time—a phenomenon termed intentional binding. Building on recent research suggesting that temporal binding occurs without intentionally performing actions, we further examined whether such perceptual compression occurs when motor action is fully absent. In three experiments, we used a novel sensory-based adaptation of the Libet

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17

Paulus, Markus, Wessel van Dam, Sabine Hunnius, Oliver Lindemann, and Harold Bekkering. "Action-effect binding by observational learning." Psychonomic Bulletin & Review 18, no. 5 (2011): 1022–28. http://dx.doi.org/10.3758/s13423-011-0136-3.

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18

Dutzi, Ilona B., and Bernhard Hommel. "The microgenesis of action-effect binding." Psychological Research Psychologische Forschung 73, no. 3 (2008): 425–35. http://dx.doi.org/10.1007/s00426-008-0161-7.

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19

Horuk, Richard, and Jerrold M. Olefsky. "Post-binding events in insulin action." Molecular and Cellular Endocrinology 42, no. 1 (1985): 1–20. http://dx.doi.org/10.1016/0303-7207(85)90002-4.

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20

NAPIER, RICHARD M., and MICHAEL A. VENIS. "Auxin action and auxin-binding proteins." New Phytologist 129, no. 2 (1995): 167–201. http://dx.doi.org/10.1111/j.1469-8137.1995.tb04291.x.

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21

Lazar, Mitchell A. "Thyroid hormone action: a binding contract." Journal of Clinical Investigation 112, no. 4 (2003): 497–99. http://dx.doi.org/10.1172/jci19479.

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22

Horuk, Richard, and Jerrold M. Olefsky. "Post binding events in insulin action." Diabetes / Metabolism Reviews 1, no. 1-2 (1985): 59–97. http://dx.doi.org/10.1002/dmr.5610010105.

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23

Foerster, Anna, Klaus Rothermund, Juhi Jayesh Parmar, Birte Moeller, Christian Frings, and Roland Pfister. "Goal-Based Binding of Irrelevant Stimulus Features for Action Slips." Experimental Psychology 68, no. 4 (2021): 206–13. http://dx.doi.org/10.1027/1618-3169/a000525.

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Abstract. Binding between representations of stimuli and actions and later retrieval of these compounds provide efficient shortcuts in action control. Recent observations indicate that these mechanisms are not only effective when action episodes go as planned, but they also seem to be at play when actions go awry. Moreover, the human cognitive system even corrects traces of error commission on the fly because it binds the intended but not actually executed response to concurrent task-relevant stimuli, thus enabling retrieval of a correct, but not actually executed response when encountering th

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24

Sani, B. P., and A. Vaid. "Specific interaction of ivermectin with retinol-binding protein from filarial parasites." Biochemical Journal 249, no. 3 (1988): 929–32. http://dx.doi.org/10.1042/bj2490929.

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Specific cellular binding proteins for retinol and retinoic acid from mammalian and avian species may mediate the action of retinoids in the control of epithelial differentiation, growth and tumorigenesis. Parasite retinol-binding protein (PRBP) and parasite retinoic acid-binding protein (PRABP) isolated and characterized from parasitic worms of the family Filarioidea might be involved in some possible action of vitamin A compounds in these parasites. Ivermectin, a potent and widely used anti-parasitic drug, competes efficiently with retinol for retinol-binding sites on PRBP, but not for the h

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25

Li, Zixu, Zhiwei Chen, Haokun Wen, Zhiheng Fu, Yupeng Hu, and Weili Guan. "ENCODER: Entity Mining and Modification Relation Binding for Composed Image Retrieval." Proceedings of the AAAI Conference on Artificial Intelligence 39, no. 5 (2025): 5101–9. https://doi.org/10.1609/aaai.v39i5.32541.

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The objective of Composed Image Retrieval (CIR) is to identify a target image that meets the requirement based on a multimodal query (including the reference image and the modification text) provided by the user. Despite the notable success of existing approaches, they fail to adequately address the modification relation between visual entities and modification actions. This limitation is non-trivial due to three challenges: 1) irrelevant factor perturbation, 2) vague semantic boundaries, and 3) implicit modification relations. To address the above challenges, we propose an Entity miNing and m

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26

Elkonin, B. D. "Productive Action." Cultural-Historical Psychology 15, no. 1 (2019): 116–22. http://dx.doi.org/10.17759/chp.2019150112.

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The key issue of the paper is the question of the means of Existence of human action and, therefore, of the actor himself/herself. The concept of ‘action’ refers to different types of action performance: effective action, play action, learning action and, finally, productive action. The paper focuses on the configuration of the Productive Action since it is the production that is considered a complete form of action performance. The Productive Action is represented as a binding of two Occurrences: the occurrence of overcoming the resistance of the past experience and the occurrence of affirmat

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27

Liesner, Marvin, Wladimir Kirsch, Roland Pfister, and Wilfried Kunde. "Spatial action–effect binding depends on type of action–effect transformation." Attention, Perception, & Psychophysics 82, no. 5 (2020): 2531–43. http://dx.doi.org/10.3758/s13414-020-02013-2.

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Ali, Ghorbat Saleh. "Mechanism of Action p53." Asian Pacific Journal of Cancer Biology 8, no. 1 (2023): 63–68. http://dx.doi.org/10.31557/apjcb.2023.8.1.63-68.

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P53 is a 393 residue protein in humans made up of five proposed domains, with which the central DNA binding domain with 100-300 sequences very important for the direct binding of p53 in the promoters of its target genes to specific response elements. P53 is a tumor suppressor gene with cellular stress like oxygen deficiency, oxidative stress, radiation and carcinogens substances, is stimulated has major roles in translational regulation and feedback processes. A wide variety of damage signals that relate to the stability, post-translational alteration and recruitment of p53 to binding sites in

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29

NOY, Noa. "Retinoid-binding proteins: mediators of retinoid action." Biochemical Journal 348, no. 3 (2000): 481–95. http://dx.doi.org/10.1042/bj3480481.

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Active vitamin A metabolites, known as retinoids, are essential for multiple physiological processes, ranging from vision to embryonic development. These small hydrophobic compounds associate in vivo with soluble proteins that are present in a variety of cells and in particular extracellular compartments, and which bind different types of retinoids with high selectivity and affinity. Traditionally, retinoid-binding proteins were viewed as transport proteins that act by solubilizing and protecting their labile ligands in aqueous spaces. It is becoming increasingly clear, however, that, in addit

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30

Repp, Bruno H. "No temporal binding of action consequences to actions in a rhythmic context." Experimental Brain Research 214, no. 4 (2011): 491–501. http://dx.doi.org/10.1007/s00221-011-2848-z.

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Franklyn, J. A., J. R. E. Davis, D. B. Ramsden, and M. C. Sheppard. "Phenytoin and thyroid hormone action." Journal of Endocrinology 104, no. 2 (1985): 201–4. http://dx.doi.org/10.1677/joe.0.1040201.

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ABSTRACT Circulating free thyroid hormone concentrations are reduced in subjects taking long-term phenytoin, a finding at variance with their euthyroid clinical state and normal serum TSH concentration. It is suggested, therefore, that phenytoin may modify the cellular effects of thyroid hormones. In order to examine the influence of phenytoin on thyroid hormone action in the pituitary gland we studied its effect on the binding of tri-iodothyronine (T3) to isolated nuclei prepared from rat anterior pituitary tissue. Phenytoin inhibited the nuclear binding of T3 in a dose-dependent fashion. Phe

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Doble, A., T. Canton, C. Malgouris, et al. "The mechanism of action of zopiclone." European Psychiatry 10, S3 (1995): 117s—128s. http://dx.doi.org/10.1016/0924-9338(96)80093-9.

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SummaryThe mechanism of action of the cyclopyrrolone hypnotic drug zopiclone involves allosteric modulation of the GABAA receptor. Zopiclone displaces the binding of [3H]-flunitrazepam with an affinity of 28 nM, and enhances the binding of the channel blocker [35S]-TBPS. The binding of zopiclone, unlike that of hypnotic benzodiazepines, is not facilitated by GABA. Zopiclone does not distinguish between GABAA receptors containing different α-subunits (BZ1 and BZ2 phenotype). Studies with protein-modifying agents (eg diethylpyrocarbonate) and photoaffinity labelling suggest that cyclopyrrolones

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33

VERNON, RICHARD G., ERIC FINLEY, ELEANOR TAYLOR, and DAVID J. FLINT. "Insulin Binding and Action on Bovine Adipocytes." Endocrinology 116, no. 3 (1985): 1195–99. http://dx.doi.org/10.1210/endo-116-3-1195.

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NOY, Noa. "Retinoid-binding proteins: mediators of retinoid action." Biochemical Journal 348, no. 3 (2000): 481. http://dx.doi.org/10.1042/0264-6021:3480481.

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35

Kirsch, Wladimir, Wilfried Kunde, and Oliver Herbort. "Intentional binding is unrelated to action intention." Journal of Experimental Psychology: Human Perception and Performance 45, no. 3 (2019): 378–85. http://dx.doi.org/10.1037/xhp0000612.

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Kasuga, Masato. "Insulin action and small GTP-binding proteins." Japanese Journal of Pharmacology 64 (1994): 57. http://dx.doi.org/10.1016/s0021-5198(19)49932-0.

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Frings, Christian, Bernhard Hommel, Iring Koch, et al. "Binding and Retrieval in Action Control (BRAC)." Trends in Cognitive Sciences 24, no. 5 (2020): 375–87. http://dx.doi.org/10.1016/j.tics.2020.02.004.

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38

Cravo, Andre M., Peter M. E. Claessens, and Marcus V. C. Baldo. "Voluntary action and causality in temporal binding." Experimental Brain Research 199, no. 1 (2009): 95–99. http://dx.doi.org/10.1007/s00221-009-1969-0.

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Ferri, Francesca, Sjoerd J. H. Ebisch, Marcello Costantini, et al. "Binding Action and Emotion in Social Understanding." PLoS ONE 8, no. 1 (2013): e54091. http://dx.doi.org/10.1371/journal.pone.0054091.

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40

Hu, Lei, Bina Santoro, Andrea Saponaro, Haiying Liu, Anna Moroni, and Steven Siegelbaum. "Binding of the auxiliary subunit TRIP8b to HCN channels shifts the mode of action of cAMP." Journal of General Physiology 142, no. 6 (2013): 599–612. http://dx.doi.org/10.1085/jgp.201311013.

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Hyperpolarization-activated cyclic nucleotide–regulated cation (HCN) channels generate the hyperpolarization-activated cation current Ih present in many neurons. These channels are directly regulated by the binding of cAMP, which both shifts the voltage dependence of HCN channel opening to more positive potentials and increases maximal Ih at extreme negative voltages where voltage gating is complete. Here we report that the HCN channel brain-specific auxiliary subunit TRIP8b produces opposing actions on these two effects of cAMP. In the first action, TRIP8b inhibits the effect of cAMP to shift

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41

Briskin, Daniel, Peter Y. Wang, and David P. Bartel. "The biochemical basis for the cooperative action of microRNAs." Proceedings of the National Academy of Sciences 117, no. 30 (2020): 17764–74. http://dx.doi.org/10.1073/pnas.1920404117.

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In cells, closely spaced microRNA (miRNA) target sites within a messenger RNA (mRNA) can act cooperatively, leading to more repression of the target mRNA than expected by independent action at each site. Using purified miRNA-Argonaute (AGO2) complexes, synthetic target RNAs, and a purified domain of TNRC6B (GW182 in flies) that is able to simultaneously bind multiple AGO proteins, we examined both the occupancies and binding affinities of miRNA-AGO2 complexes and target RNAs with either one site or two cooperatively spaced sites. On their own, miRNA-AGO2 complexes displayed little if any coope

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Pelletier, Audrey, Alexandre Mayran, Arthur Gouhier, James G. Omichinski, Aurelio Balsalobre, and Jacques Drouin. "Pax7 pioneer factor action requires both paired and homeo DNA binding domains." Nucleic Acids Research 49, no. 13 (2021): 7424–36. http://dx.doi.org/10.1093/nar/gkab561.

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Abstract The pioneer transcription factor Pax7 contains two DNA binding domains (DBD), a paired and a homeo domain. Previous work on Pax7 and the related Pax3 showed that each DBD binds a cognate DNA sequence, thus defining two targets of binding and possibly modalities of action. Genomic targets of Pax7 pioneer action leading to chromatin opening are enriched for composite DNA target sites containing juxtaposed sites for both paired and homeo domains. The present work investigated the implication of the DBDs in pioneer action. We show that the composite sequence is a higher affinity binding s

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43

Ruess, Miriam, Roland Thomaschke, and Andrea Kiesel. "Intentional Binding for Unintended Effects." Timing & Time Perception 8, no. 3-4 (2020): 341–49. http://dx.doi.org/10.1163/22134468-bja10005.

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We execute most of our movements in order to elicit an intended effect. This kind of intentionality is commonly assumed to drive a temporal illusion, referred to as Intentional Binding (IB): Stimuli intentionally elicited by one’s own action (i.e., effects) are perceived as temporally earlier compared to unintentionally occurring stimuli (not elicited by one’s own action). It is currently under debate whether intentionality is necessary for IB to occur, or whether causality might be sufficient for IB to occur. In the present study, we investigated the importance of an intention for the occurre

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44

Tonn, S., R. Pfister, A. L. Klaffehn, L. Weller, and K. A. Schwarz. "Two faces of temporal binding: Action- and effect-binding are not correlated." Consciousness and Cognition 96 (November 2021): 103219. http://dx.doi.org/10.1016/j.concog.2021.103219.

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45

Cao, Liyu, Michael Steinborn, Wilfried Kunde, and Barbara Haendel. "Action force modulates action binding: evidence for a multisensory information integration explanation." Experimental Brain Research 238, no. 9 (2020): 2019–29. http://dx.doi.org/10.1007/s00221-020-05861-4.

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46

Osan, Jaspreet Kaur, and Andrea Ferrante. "Is MHCII-restricted immunodominance determined by HLA-DM action?" Journal of Immunology 198, no. 1_Supplement (2017): 146.14. http://dx.doi.org/10.4049/jimmunol.198.supp.146.14.

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Abstract Binding of antigenic peptides to class II MHC molecules (MHCII) and the activity of the “editing” molecule HLA-DM (DM) on the resulting peptide-MHCII complexes are mechanisms critical to immunodominance, yet not fully understood. Our previous results indicate that peptide binding to the human MHCII HLA-DR1 (DR1) is a flexible event in that different thermodynamic components compensate each other to the possible extent to achieve a stable complex, and the energetic mechanism responsible for binding is reflected in the structural lability of the resulting complex. Here we apply our ther

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47

Borhani, Khatereh, Brianna Beck, and Patrick Haggard. "Choosing, Doing, and Controlling: Implicit Sense of Agency Over Somatosensory Events." Psychological Science 28, no. 7 (2017): 882–93. http://dx.doi.org/10.1177/0956797617697693.

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Sense of agency—a feeling of control over one’s actions and their outcomes—might include at least two components: free choice over which outcome to pursue and motoric control over the action causing the outcome. We orthogonally manipulated locus of outcome choice (free or instructed choice) and motoric control (active or passive movement), while measuring the perceived temporal attraction between actions and outcomes ( temporal binding) as an implicit marker of agency. Participants also rated stimulus intensity so that we could measure sensory attenuation, another possible implicit marker of a

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Marsault, R., E. Feolde, and C. Frelin. "Receptor externalization determines sustained contractile responses to endothelin-1 in the rat aorta." American Journal of Physiology-Cell Physiology 264, no. 3 (1993): C687—C693. http://dx.doi.org/10.1152/ajpcell.1993.264.3.c687.

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The role of receptor internalization and recycling in the vasoconstrictor action of endothelin-1 (ET-1) is investigated using a combination of biochemical and physiological experiments. The binding of 125I-ET-1 to cultured aortic myocytes is first defined. Binding is rapidly followed by an internalization of the peptide. Part of the receptor sites then slowly reappears at the cell surface via a cycloheximide-insensitive mechanism. Evidence that externalizing receptors are functional and can trigger contractions is presented. Finally, the actions of cyclo[D-Trp-D-Asp-Pro-D-Val-Leu] (BQ-123), an

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Hansanant, Nopakorn, and Leif Smith. "Occidiofungin: Actin Binding as a Novel Mechanism of Action in an Antifungal Agent." Antibiotics 11, no. 9 (2022): 1143. http://dx.doi.org/10.3390/antibiotics11091143.

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The identification and development of natural products into novel antimicrobial agents is crucial to combat the rise of multidrug-resistant microorganisms. Clinical fungal isolates have been identified, which have shown resistance to all current clinical antifungals, highlighting a significant need to develop a novel antifungal agent. One of the natural products produced by the bacterium Burkholderia contaminans MS14 is the glycolipopeptide occidiofungin. Occidiofungin has demonstrated in vitro activity against a multitude of fungal species, including multidrug-resistant Candida auris strains,

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STROM, CHRISTINA S., XIANG YANG LIU, and ZONGCHAO JIA. "STRUCTURAL BASIS OF ANTIFREEZE PROTEIN ACTION." Biophysical Reviews and Letters 01, no. 03 (2006): 259–70. http://dx.doi.org/10.1142/s1793048006000203.

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Antifreeze Proteins (AFPs) modify the growth rates and orientations of ice crystal facets through attainment of the best structural match. The insect-type AFPs have ice binding surfaces (IBS) with regularly spaced binding intervals in two directions that engage the primary ice surfaces and reduce their growth rates preferentially. The primary ice surfaces are kinetically stable and have fixed orientations, since they are strongly bonded in two directions. The fish-type AFPs have one-dimensional helical and irregular globular IBSs that are either linearly extended with regular ice binding inter

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