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Rozprawy doktorskie na temat „Bulk Drug”

Autor: Grafiati

Data publikacji: 7 czerwca 2025

Data aktualizacji: 2 sierpnia 2025

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1

Lewis, Paul O., David B. Cluck, Jessica D. Huffman, Amanda P. Ogle, and Stacy D. Brown. "Stability of a Pyrimethamine Suspension Compounded from Bulk Powder." Digital Commons @ East Tennessee State University, 2017. https://doi.org/10.2146/ajhp160551.

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Purpose:Development of a stability-indicating high-performance liquid chromatography (HPLC) method for pyrimethamine analysis, with subsequent application of that method to assess the 90-day stability of a pyrimethamine suspension compounded from bulk USP-grade pyrimethamine powder, is described. Methods:A stability-indicating method of HPLC with ultraviolet detection specific to pyrimethamine was developed according to pharmacopeial recommendations and validated. The method was applied to investigate the stability of a 2-mg/mL pyrimethamine suspension in a vehicle consisting of Ora-Plus and O

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Tindle, R. "Deliberate crystal habit modification of pharmaceuticals and its effect on bulk and tabletting properties." Thesis, University of Nottingham, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378939.

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Denk, Oliver Matthias. "Impurity studies of bulk drug substances by capillary electrophoresis and high performance liquid chromatography." Thesis, University of Strathclyde, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248566.

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Vukmirovic, Neda. "Drug deposition and distribution in healthy and atherosclerotic arteries and in models of atherosclerosis following bulk or stent-based drug delivery." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/40871.

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Thesis (Ph. D.)--Harvard-MIT Division of Health Sciences and Technology, 2007.<br>Includes bibliographical references.<br>Drug eluting stents have revolutionized the practice of medicine and the landscape of medical devices. Yet, more than four years after introduction clinical trial data and clinical use have still not fully clarified what drives the safety and efficacy of these devices. The goal of this thesis was to help fill this void by describing the mechanisms by which stent-eluted drugs are distributed within healthy and atherosclerotic vascular models. In the first part of the thesis

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Jansson, Björn. "Models for the transfer of drugs from the nasal cavity to the central nervous system /." Uppsala : Acta Universitatis Upsaliensis: Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3905.

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Didonet, Juliana. "Avaliação da bula de medicamentos sob a ótica dos idosos." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2007. http://hdl.handle.net/10183/23919.

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O objetivo deste estudo é avaliar a bula dos medicamentos sob a ótica dos idosos verificando os aspectos da compreensão, visibilidade, legibilidade e as opiniões relacionadas à bula. Foram entrevistadas pessoas que freqüentavam grupos de atividades para idosos, localizados no estado do Rio Grande do Sul. Um total de 88 participantes leu a bula do fármaco atenolol. Destes, um grupo de 47 pessoas leu a bula redigida de acordo com a Portaria nº 110/1997 e outro de 41 pessoas leu a bula do mesmo fármaco redigida de acordo com a RDC nº 140/2003, sendo que após a leitura recebiam um valor de pontuaç

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Abahamye, Aloysius. "Cost comparison between repackaging bulk oral solid medicines and purchasing manufacturer-prepared patient-ready packs in the public sector in South Africa." Thesis, Nelson Mandela Metropolitan University, 2014. http://hdl.handle.net/10948/d1020596.

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In an attempt to have medicines available in patient-ready packs (PRPs) prior to the dispensing process, the provincial medicine depots in South Africa have, for many years, been repackaging bulk medicines into PRPs. Notwithstanding the fact that bulk medicine packages may have been the only packages available from the manufacturers to service the Primary Health Care (PHC) sector, the main aim of this process was to ensure that medicines were available in PRPs for dispensing to patients, thus, minimising the time spent on each prescription by the pharmacist, pharmacist’s assistant or Nurse. Cu

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Dick, Graeme. "Development and use of a discrete element model for simulating the bulk strand flow in a rotary drum blender." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/1517.

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In 2006 resin accounted for approximately 17% of the direct manufacturing costs for oriented strand board (OSB). Because of their increased dependency on pMDI-resins, this percentage is likely greater for oriented strand lumber (OSL) and laminated strand lumber (LSL). The cost of PF- and pMDI-resins is expected to face upward pressure as the cost of their primary constituents, natural gas and crude oil, continue to reach new highs. Therefore, there is strong economic incentive to optimize the use of resin in the production of these three products. This can be accomplished by addressing tw

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Silva, João Vitor Ferrari da. "Fácil bula: sistema que estrutura o bulário eletrônico da Anvisa." Universidade Tecnológica Federal do Paraná, 2016. http://repositorio.utfpr.edu.br/jspui/handle/1/2551.

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O trabalho desempenhado pelos profissionais da área de saúde quando voltado ao cuidado das pessoas consiste, por vezes, na escolha dos melhores medicamentos para o sucesso terapêutico no tratamento de pacientes. Existem vários medicamentos disponíveis no mercado brasileiro, assim para que o profissional encontre as informações sobre o medicamento que pode ser melhor indicado para o paciente há aplicativos e ferramentas que facilitam a pesquisa dos medicamentos e auxiliam o trabalho deste especialista. Contudo em nossa busca não foram encontrados sistemas que possuem a identificação de reações

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Bergman, Ulrika. "Transfer and toxicity of some drugs and chemicals in the olfactory mucosa and bulb /." Uppsala : Swedish Univ. of Agricultural Sciences (Sveriges lantbruksuniv.), 2000. http://epsilon.slu.se/avh/2000/91-576-5909-5.pdf.

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Normington, Charmaine. "Genotoxic effects of NSAIDs and hydrocortisone in bulk and nano forms in lymphocytes from patients with haematological cancers." Thesis, University of Bradford, 2017. http://hdl.handle.net/10454/17440.

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Chronic inflammation is intimately linked with cancer development and progression and therefore reducing or eliminating inflammation represents a logical treatment and prevention strategy. Studies have shown that anti-inflammatory agents have anti-tumour effects in cancers, with reduced metastases and mortality. Current use of anti-inflammatory agents in the treatment and prevention of cancer is limited by their toxicity and side effects. The emerging field of nanotechnology allows the fundamental properties of a drug to be altered, creating a product with improved reactivity and bioavailabili

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Espefält, Westin Ulrika. "Olfactory Transfer of Analgesic Drugs After Nasal Administration." Doctoral thesis, Uppsala universitet, Institutionen för farmaci, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7829.

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Nasal administration of analgesics for achieving rapid pain relief is currently a topic of great interest. The blood-brain barrier (BBB) restricts access to the central nervous system (CNS) for several central-acting drugs, such as morphine and dihydroergotamine, which results in a substantial effect delay. Evidence for the olfactory transfer of drugs from the nasal cavity to the CNS after nasal administration, bypassing the BBB, is available for both animals and humans. The aims of this thesis were to study the olfactory transfer of morphine to the CNS after nasal administration, and to compa

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Ruivo, Stephan Michael Gaspar. "Otimização dos medicamentos : a venda de medicamentos em quantidades individualizadas em Portugal." Master's thesis, Instituto Superior de Economia e Gestão, 2015. http://hdl.handle.net/10400.5/10545.

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Mestrado em Contabilidade, Fiscalidade e Finanças Empresariais<br>A dispensa de medicamentos em quantidades individualizadas (unidose) é uma alternativa ao método que se pratica atualmente em Portugal, isto é, o método de caixa industrializada. Contudo, existe alguma controvérsia em relação ao impacto que uma possível alteração pode causar. Este estudo tem como objetivo analisar as consequências que a dispensa de medicamentos em quantidades individualizadas pode ter na gestão das farmácias. De forma a avaliar estas consequências foi realizado um inquérito dirigido às farmácias de Portugal Cont

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Jansson, Björn. "Models for the Transfer of Drugs from the Nasal Cavity to the Central Nervous System." Doctoral thesis, Uppsala University, Department of Pharmacy, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3905.

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<p>The blood-brain barrier restricts the access of many compounds, including therapeutic agents, to the brain. Several human studies indicate that nasal administration of hydrophilic compounds, such as peptides, can bypass the blood-brain barrier. The aims of this thesis were to develop and refine models for this direct nose-to-brain transfer.</p><p>In a mouse model, [<sup>3</sup>H]-dopamine was given as a unilateral nasal dose. The resulting radioactivity in the ipsilateral olfactory bulb was significantly higher than that in the contralateral bulb and peaked at 4 h. Tape section autoradiogra

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15

Jiggens, John Lawrence. "Marijuana Australiana: Cannabis use, popular culture and the Americanisation of drugs policy in Australia, 1938-1988." Queensland University of Technology, 2004. http://eprints.qut.edu.au/15949/.

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The word 'marijuana' was introduced to Australia by the US Bureau of Narcotics via the Diggers newspaper, Smith's Weekly, in 1938. Marijuana was said to be 'a new drug that maddens victims' and it was sensationally described as an 'evil sex drug'. The resulting tabloid furore saw the plant cannabis sativa banned in Australia, even though cannabis had been a well-known and widely used drug in Australia for many decades. In 1964, a massive infestation of wild cannabis was found growing along a stretch of the Hunter River between Singleton and Maitland in New South Wales. The explosion in Aus

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Jiggens, John Lawrence. "Marijuana Australiana : cannabis use, popular culture and the Americanisation of drugs policy in Australia, 1938-1988." Thesis, Queensland University of Technology, 2004. https://eprints.qut.edu.au/15949/1/John_Jiggens_Thesis.pdf.

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The word 'marijuana' was introduced to Australia by the US Bureau of Narcotics via the Diggers newspaper, Smith's Weekly, in 1938. Marijuana was said to be 'a new drug that maddens victims' and it was sensationally described as an 'evil sex drug'. The resulting tabloid furore saw the plant cannabis sativa banned in Australia, even though cannabis had been a well-known and widely used drug in Australia for many decades. In 1964, a massive infestation of wild cannabis was found growing along a stretch of the Hunter River between Singleton and Maitland in New South Wales. The explosion in Aus

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Yu-ChengShih and 施昱丞. "Study of Magnetic Drug Delivery System Using High Temperature Bulk Superconducting Magnet." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/bjwn4m.

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Anderson, Mary Elizabeth. "Measurements and Linear Wave Theory Based Simulations of Vegetated Wave Hydrodynamics for Practical Applications." Thesis, 2010. http://hdl.handle.net/1969.1/ETD-TAMU-2010-08-8348.

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Wave attenuation by vegetation is a highly dynamic process and its quantification is important for accurately understanding and predicting coastal hydrodynamics. However, the influence of vegetation on wave dissipation is not yet fully established nor implemented in current hydrodynamic models. A series of laboratory experiments were conducted at the Haynes Coastal Engineering Laboratory and in a two-dimensional flume at Texas A and M University to investigate the influence of relative vegetation height, stem density, and stem spacing uniformity on wave attenuation. Vegetation fields were rep

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19

Alotaibi, Amal, P. Bhatnagar, Mojgan Najafzadeh, K. C. Gupta, and Diana Anderson. "Tea phenols in bulk and nanoparticle form modify DNA damage in human lymphocytes from colon cancer patients and healthy individuals treated in vitro with platinum-based chemotherapeutic drugs." 2012. http://hdl.handle.net/10454/9022.

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No<br>Tea catechin epigallocatechin-3-gallate (EGCG) and other polyphenols, such as theaflavins (TFs), are increasingly proving useful as chemopreventives in a number of human cancers. They can also affect normal cells. The polyphenols in tea are known to have antioxidant properties that can quench free radical species, and pro-oxidant activities that appear to be responsible for the induction of apoptosis in tumor cells. The bioavailability of these natural compounds is an important factor that determines their efficacy. Nanoparticle (NP)-mediated delivery techniques of EGCG and TFs have been

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Chen, Sz-Ju, and 陳思如. "The analysis of Bao-Can Wang’s four percussion works─Roll call of soldiers by the king of Qin, Rolling walnuts, The drum beats of Yellow Rivers,and Fight between the bull and the tiger." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/12999571087670453541.

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碩士<br>中國文化大學<br>音樂學系碩士班中國音樂組<br>99<br>The study is to understand Baocan Wang’s motive for creation and his performing philosophy regarding the four “Jiang-Zhou Drum Music” created by Baocan Wang - “Roll call of soldiers by the king of Qin”, “Rolling walnuts”, “The drum beats of Yellow River”, “Fight between the bull and the tiger”, which are frequently performed in recent years in Taiwan through data collection and analysis, interview and field learning and operation. The author further interprets and analyzes the ideas closest to original inventor, which regarded as a reference to future perf

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