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1

Lu, Tao, Lisa Oomens, Leon W. M. M. Terstappen, and Jai Prakash. "In Vivo Detection of Circulating Cancer-Associated Fibroblasts in Breast Tumor Mouse Xenograft: Impact of Tumor Stroma and Chemotherapy." Cancers 15, no. 4 (2023): 1127. http://dx.doi.org/10.3390/cancers15041127.

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Cancer-associated fibroblasts (CAFs) are important drivers in the tumor microenvironment and facilitate the growth and survival of tumor cells, as well as metastasis formation. They may travel together with tumor cells to support their survival and aid in the formation of a metastatic niche. In this study, we aimed to study circulating CAFs (cCAFs) and circulating tumor cells (CTCs) in a preclinical breast tumor model in mice in order to understand the effect of chemotherapy on cCAFs and CTC formation. Tumors with MDA-MB-231 human breast tumor cells with/without primary human mammary fibroblas
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Woo, Hyeongjung, Simon A. Joosse, Frederike Harten, Felix Hilpert, Klaus Pantel, and Minseok S. Kim. "Abstract A004: Full spectrum isolation technique-based dual circulating rare cells analysis to maximize early cancer diagnosis." Clinical Cancer Research 30, no. 21_Supplement (2024): A004. http://dx.doi.org/10.1158/1557-3265.liqbiop24-a004.

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Abstract Liquid biopsy (LB) is essential in precision medicine, enabling real-time tumor monitoring through repeated sampling. However, its diagnostic sensitivity and accuracy are limited by the low detection rate of circulating tumor cells (CTCs). For example, in breast cancer, the CTC detection rate exhibited only 20%, significantly limiting its clinical utility. This limitation arises since existing technologies selectively isolate specific phenotypes of CTCs, failing to capture others, such as mesenchymal CTCs, which are associated with poor prognosis. These mesenchymal CTCs often evade de
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Muchlińska, Anna, Robert Wenta, Wiktoria Ścińska, et al. "Improved Characterization of Circulating Tumor Cells and Cancer-Associated Fibroblasts in One-Tube Assay in Breast Cancer Patients Using Imaging Flow Cytometry." Cancers 15, no. 16 (2023): 4169. http://dx.doi.org/10.3390/cancers15164169.

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Circulating tumor cells (CTCs) and circulating cancer-associated fibroblasts (cCAFs) have been individually considered strong indicators of cancer progression. However, technical limitations have prevented their simultaneous analysis in the context of CTC phenotypes different from epithelial. This study aimed to analyze CTCs and cCAFs simultaneously in the peripheral blood of 210 breast cancer patients using DAPI/pan-keratin (K)/vimentin (V)/alpha-SMA/CD29/CD45/CD31 immunofluorescent staining and novel technology—imaging flow cytometry (imFC). Single and clustered CTCs of different sizes and p
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Mzingula, Emmanuel P., Fatihiya A. Massawe, and Raymond J. Salanga. "Impact of sustained adoption of Climate-Smart Agriculture on crop productivity in the West Usambara Mountains, Tanzania." Journal of Agriculture, Science and Technology 23, no. 5 (2025): 52–75. https://doi.org/10.4314/jagst.v23i5.4.

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Climate change in the West Usambara Mountains has added more challenges to smallholder farmers who are already negatively affected by land degradation. Sustained adoption of Climate-Smart Agriculture (CSA) can improve crop productivity by addressing challenges posed by both climate change and land degradation. From 2011 to 2019, the Climate Change Agriculture and Food Security (CCAFS) project disseminated and promoted the use of CSA technologies to improve crop productivity. Understanding the impact of CSA on crop productivity among farming households that received interventions is crucial for
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RAI, MUNMUN, PREM CHAND, K. C. KALVANIYA, et al. "How profitable climate smart agricultural practices are? Voice of farmers from rice-wheat ecologies." Indian Journal of Agricultural Sciences 90, no. 7 (2020): 1271–76. http://dx.doi.org/10.56093/ijas.v90i7.105578.

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Farm record keeping can provide a look into the health of farm business, its profitability, and a snapshot in time of its present equity. However, farmers in developing country seldom maintain written records of farm operations. In many cases, farmers consider it worthless exercise. They feel overwhelmed by record keeping because it takes time, a change in behavior and for some, the requirement to learn a new skill. This study assesses the role of record keeping, particularly among women and youth using data collected in afarmers participatory research undertaken under the CGIAR Research Progr
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Medina, Bruno, Lawrence Carey, Corey Amiot, et al. "A Random Forest Method to Forecast Downbursts Based on Dual-Polarization Radar Signatures." Remote Sensing 11, no. 7 (2019): 826. http://dx.doi.org/10.3390/rs11070826.

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The United States Air Force’s 45th Weather Squadron provides wind warnings, including those for downbursts, at the Cape Canaveral Air Force Station and Kennedy Space Center (CCAFS/KSC). This study aims to provide a Random Forest model that classifies thunderstorms’ downburst and null events using a 35-knot wind threshold to separate these two categories. The downburst occurrence was assessed using a dense network of wind observations around CCAFS/KSC. Eight dual-polarization radar signatures that are hypothesized to have physical implications for downbursts at the surface were automatically ca
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Dinesh, Dhanush, Robert Zougmore, Joost Vervoort, et al. "Facilitating Change for Climate-Smart Agriculture through Science-Policy Engagement." Sustainability 10, no. 8 (2018): 2616. http://dx.doi.org/10.3390/su10082616.

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Climate change impacts on agriculture have become evident, and threaten the achievement of global food security. On the other hand, the agricultural sector itself is a cause of climate change, and if actions are not taken, the sector might impede the achievement of global climate goals. Science-policy engagement efforts are crucial to ensure that scientific findings from agricultural research for development inform actions of governments, private sector, non-governmental organizations (NGOs) and international development partners, accelerating progress toward global goals. However, knowledge g
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8

Mzingula, Emmanuel Paul, Fatihiya Massawe, and Raymond Salanga. "Effects of Perceived Relative Advantage and Complexity on Sustained Adoption of Indigenous Weather Forecasts in the West Usambara Mountains, Tanzania." African Journal of Empirical Research 5, no. 3 (2024): 988–1000. http://dx.doi.org/10.51867/ajernet.5.3.84.

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Agriculture is a climate-sensitive economic sector that requires reliable and precise weather information to enable farmers to cope with seasonal weather as well as adapt to climate change to increase yields. In the West Usambara Mountains, the Climate Change Agriculture and Food Security (CCAFS) project promoted the integration of indigenous weather forecasts with scientific weather forecast services from 2011 to 2019. The project aimed to enhance the availability and precision of weather information for reducing agricultural risks and losses posed by climate change. The objective of this stu
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9

Feliciano, Diana, Dali Rani Nayak, Sylvia Helga Vetter, and Jon Hillier. "CCAFS-MOT - A tool for farmers, extension services and policy-advisors to identify mitigation options for agriculture." Agricultural Systems 154 (June 2017): 100–111. http://dx.doi.org/10.1016/j.agsy.2017.03.006.

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Hettich, Annika, Neel I. Nissen, Morten A. Karsdal, and Nicholas Willumsen. "Abstract 4274: Unraveling collagen signatures in cancer-associated fibroblasts: A biomarker-driven approach." Cancer Research 84, no. 6_Supplement (2024): 4274. http://dx.doi.org/10.1158/1538-7445.am2024-4274.

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Abstract Background: The tumor microenvironment (TME) plays a crucial role in driving tumor development. Among the constituents of the tumor stroma, cancer-associated fibroblasts (CAFs) are a significant component. CAFs are actively involved in tumor progression by modulating the architecture of the TME through increased deposition of various collagens resulting in tumor fibrosis. Several studies have shown that CAFs have heterogeneity within, and between, individual tissues. TGF-β is thought to be the main driver of tumor fibrosis, however, the field lacks a characterization of the specific c
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11

Koglo, Y., A. Abdulkadir, D. Feliciano, and A. Okhimamhe. "Efficacy of Integrated Straw Formulations on Lowland Rice Field Organic Carbon and Greenhouse Gas Emissions Using CCAFS-MOT Model in Niger State, Nigeria." American Journal of Experimental Agriculture 13, no. 5 (2016): 1–11. http://dx.doi.org/10.9734/ajea/2016/27088.

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Kim, Kimin, Yeh Joo Sohn, Ruri Lee, et al. "Cancer-Associated Fibroblasts Differentiated by Exosomes Isolated from Cancer Cells Promote Cancer Cell Invasion." International Journal of Molecular Sciences 21, no. 21 (2020): 8153. http://dx.doi.org/10.3390/ijms21218153.

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Cancer-associated fibroblasts (CAFs) in the cancer microenvironment play an essential role in metastasis. Differentiation of endothelial cells into CAFs is induced by cancer cell-derived exosomes secreted from cancer cells that transfer molecular signals to surrounding cells. Differentiated CAFs facilitate migration of cancer cells to different regions through promoting extracellular matrix (ECM) modifications. However, in vitro models in which endothelial cells exposed to cancer cell-derived exosomes secreted from various cancer cell types differentiate into CAFs or a microenvironmentally con
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13

PAVITHRAPRIYA, S., A. RAMACHANDRAN, SN AHAMEDIBRAHIM, and K. PALANIVELU. "Climate variability trend and extreme indices for the Thanjavur Delta region of Tamil Nadu in South India." MAUSAM 73, no. 2 (2022): 237–50. http://dx.doi.org/10.54302/mausam.v73i2.5475.

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The Thanjavur delta region of Tamil Nadu vastly depends on agriculture. The current trend of agricultural production has been significantly affected due to changes in climatic condition. The observed parameters have been acquired from IMD (Indian Meteorological Department.) for the period 1971-2014 and CCAFS (Climate Change, Agricultural and Food Security) over the period 2015–2050 for climate trend and extremities analysis. This study indicated that observed maximum temperature (TMax) has significantly increased about 0.8 ºC, 1.5 ºC and 0.9 ºC in ARP, NPT and IMD grid respectively over the pe
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14

Ambaw, Gebermedihin, John W. Recha, Abebe Nigussie, Dawit Solomon, and Maren Radeny. "Soil Carbon Sequestration Potential of Climate-Smart Villages in East African Countries." Climate 8, no. 11 (2020): 124. http://dx.doi.org/10.3390/cli8110124.

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Climate-Smart Villages (CSVs) were established by the CGIAR Research Program on Climate Change, Agriculture and Food Security (CCAFS) in the East African countries of Kenya, Tanzania and Uganda to test and promote a portfolio of climate-smart agriculture (CSA) practices that have climate change mitigation potential. This study evaluated the soil carbon sequestration potential of these CSVs compared to the control land use that did not have CSA practices. At the one-meter depth, soil carbon stocks increased by 20–70%, 70–86%, and 51–110% in Kenya, Tanzania and Uganda CSVs, respectively, compare
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15

Gupta, Rajeev Kumar, Arun Shankar, Bijay-Singh, et al. "Precision Nitrogen Management in Bt Cotton (Gossypium hirsutum) Improves Seed Cotton Yield and Nitrogen Use Efficiency, and Reduces Nitrous Oxide Emissions." Sustainability 14, no. 4 (2022): 2007. http://dx.doi.org/10.3390/su14042007.

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Field experiments were conducted to establish precision N management technology for nitrogen (N) topdressings in Bt (Bacillus thuringiensis) cotton (Gossypium hirsutum) along with the quantification of nitrous oxide emissions from the soil. The treatments consisted of five fixed N rates (0, 60, 90, 120 and 150 kg N ha−1 applied in two split doses) and eight site-specific N management (SSNM) treatments of applying different N rates at 40 days after sowing (DAS) and the application of leaf colour chart (LCC)-guided 30, 45 or 60 kg N ha−1 at 55 DAS only in four treatments and at both 55 and 85 DA
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Charles, Bwalya Chisanga, Phiri Elijah, and R. N. Chinene Vernon. "Statistical Bias Correction of Fifth Coupled Model Intercomparison Project Data from the CGIAR Research Program on Climate Change, Agriculture and Food Security - Climate Portal for Mount Makulu, Zambia." British Journal of Applied Science & Technology 21, no. 4 (2017): 1–16. https://doi.org/10.9734/BJAST/2017/33531.

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Although Global Climate Models (GCMs) are regarded as the best tools available for future climate projections, there are biases in simulating precipitation and temperature due to their coarse spatial resolution and cannot be used directly to assess the impact of projected climate change. The study objective was to investigate how bias correction methods impact the modelled future climate change under Representative Concentration Pathway 8.5 (RCP8.5) for 2020-2050.Reanalysisdata (1980-2000) and bias correction approaches (change factor [CF], nudging and Quantile Mapping [QM]) were used to calib
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17

Opare, Phyllis, Johnson O. Akintonde, Daniel Obeng-Ofori, and Valerie Nelson. "Using climate analogue tools to explore and build smallholder farmer capacity for climate smart agriculture." AAS Open Research 1 (August 10, 2018): 24. http://dx.doi.org/10.12688/aasopenres.12822.1.

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Background: The phenomenon of climate change (CC) and its attendant challenges in agriculture have been widely document. Climate Smart Agriculture (CSA) focuses on sustainable agriculture intensification for food sovereignty through the adoption of mitigation and adaptation practices. Agriculture provides the livelihood for 70% of rural poor in the developing world, so building farmer capacity in CSA is imperative for food security. Studies show that transformative change must be bottom-up – integrating scientific and ethical dimensions, using participatory research approaches that employ simp
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Khadioli, N., Z. E. H. Tonnang, E. Muchugu, et al. "Effect of temperature on the phenology ofChilo partellus(Swinhoe) (Lepidoptera, Crambidae); simulation and visualization of the potential future distribution ofC. partellusin Africa under warmer temperatures through the development of life-table parameters." Bulletin of Entomological Research 104, no. 6 (2014): 809–22. http://dx.doi.org/10.1017/s0007485314000601.

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AbstractMaize (Zea mays) is a major staple food in Africa. However, maize production is severely reduced by damage caused by feeding lepidopteran pests. In East and Southern Africa,Chilo partellusis one of the most damaging cereal stem borers mainly found in the warmer lowland areas. In this study, it was hypothesized that the future distribution and abundance ofC. partellusmay be affected greatly by the current global warming. The temperature-dependent population growth potential ofC. partelluswas studied on artificial diet under laboratory conditions at six constant temperatures (15, 18, 20,
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Grützner, Julian, Fabian Billenkamp, Daniel-Timon Spanka, et al. "The small DUF1127 protein CcaF1 from Rhodobacter sphaeroides is an RNA-binding protein involved in sRNA maturation and RNA turnover." Nucleic Acids Research 49, no. 6 (2021): 3003–19. http://dx.doi.org/10.1093/nar/gkab146.

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Abstract Many different protein domains are conserved among numerous species, but their function remains obscure. Proteins with DUF1127 domains number >17 000 in current databases, but a biological function has not yet been assigned to any of them. They are mostly found in alpha- and gammaproteobacteria, some of them plant and animal pathogens, symbionts or species used in industrial applications. Bioinformatic analyses revealed similarity of the DUF1127 domain of bacterial proteins to the RNA binding domain of eukaryotic Smaug proteins that are involved in RNA turnover and have a role
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Teleubay, Zhanassyl, Farabi Yermekov, Arman Rustembayev, et al. "Comparison of Climate Change Effects on Wheat Production under Different Representative Concentration Pathway Scenarios in North Kazakhstan." Sustainability 16, no. 1 (2023): 293. http://dx.doi.org/10.3390/su16010293.

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Adverse weather conditions, once rare anomalies, are now becoming increasingly commonplace, causing heavy losses to crops and livestock. One of the most immediate and far-reaching concerns is the potential impact on agricultural productivity and global food security. Although studies combining crop models and future climate data have been previously carried out, such research work in Central Asia is limited in the international literature. The current research aims to harness the predictive capabilities of the CRAFT (CCAFS Regional Agricultural Forecasting Toolbox) to predict and comprehend th
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De Felice, Camillo. "18. ‘O CCAFÈ." Babel, no. 35 (January 1, 2017): 54–55. http://dx.doi.org/10.4000/babel.4751.

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Merga, Damtew Degefe, Dereje Adeba, Motuma Shiferaw Regasa, and Megersa Kebede Leta. "Evaluation of Surface Water Resource Availability under the Impact of Climate Change in the Dhidhessa Sub-Basin, Ethiopia." Atmosphere 13, no. 8 (2022): 1296. http://dx.doi.org/10.3390/atmos13081296.

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Climate change, with its reaching implications, has become a popular topic in recent years. Among the many aspects of climate change, one of the most pressing concerns has been identified as the impact on the terrestrial water cycle, which has a direct impact on human settlement and ecosystems. The paper begins by reviewing previous studies, and then identifies their flaws and future research directions. The effects of climate change on surface water resources in the Dhidhessa Sub-basin, Abbay Basin, Ethiopia, were studied as practices. For future potential climate change, the results of globa
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Kumngern, Montree, Thanat Nonthaputha, and Fabian Khateb. "Arbitrary Waveform Generators Using Current-Controlled Current Conveyor Transconductance Amplifier and Current Conveyor Analog Switches." Journal of Circuits, Systems and Computers 28, no. 11 (2019): 1950179. http://dx.doi.org/10.1142/s0218126619501792.

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This paper presents a new amplitude modulation (AM), frequency modulation (FM), amplitude shift keying (ASK), frequency shift keying (FSK), phase shift keying (PSK) and quadrature amplitude modulation (QAM) waveform generators using current current-controlled conveyor transconductance amplifier (CCCTA) and current conveyor analog switches (CCASs). The CCCTA around with capacitors and resistors are used to generate high-frequency carrier which is worked as a quadrature oscillator. The oscillating frequency of oscillator can be controlled using the bias current of CCCTA, therefore FM and FSK wav
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MIN, LEQUAN, and GUANRONG CHEN. "GENERALIZED SYNCHRONIZATION IN AN ARRAY OF NONLINEAR DYNAMIC SYSTEMS WITH APPLICATIONS TO CHAOTIC CNN." International Journal of Bifurcation and Chaos 23, no. 01 (2013): 1350016. http://dx.doi.org/10.1142/s0218127413500168.

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This paper establishes some generalized synchronization (GS) theorems for a coupled discrete array of difference systems (CDADS) and a coupled continuous array of differential systems (CCADS). These constructive theorems provide general representations of GS in CDADS and CCADS. Based on these theorems, one can design GS-driven CDADS and CCADS via appropriate (invertible) transformations. As applications, the results are applied to autonomous and nonautonomous coupled Chen cellular neural network (CNN) CDADS and CCADS, discrete bidirectional Lorenz CNN CDADS, nonautonomous bidirectional Chua CN
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Smith, Luther. "Specialty Certifications for CCAs." CSA News 60, no. 1 (2015): 34–35. http://dx.doi.org/10.2134/csa2015-60-1-20.

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McBride, James M., and James R. Larkins. "CCAF Article Title Questioned." Change: The Magazine of Higher Learning 32, no. 4 (2000): 5. http://dx.doi.org/10.1080/00091380009601740.

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Min, Lequan, and Guanrong Chen. "Generalized Stability in an Array of Nonlinear Dynamic Systems with Applications to Chaotic CNN." International Journal of Bifurcation and Chaos 27, no. 02 (2017): 1750029. http://dx.doi.org/10.1142/s0218127417500298.

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This paper introduces a generalized stability with respect to a transformation (GST) for a coupled discrete array of difference systems (CDADS) and a coupled continuous array of differential systems (CCADS). Some constructive theorems provide general representations of GST in both CDADS and CCADS. Using these theorems, one can design GST-based CADS and CCADS via appropriate transformations. As examples, the results are applied to autonomous and nonautonomous coupled discrete and differentiable Lorenz cellular neural network (CNN) CADS and CCADS; differentiable Chen CNN CCADS, and discrete sine
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Ohtomo, Toshichika, Tsugiaki Kobayashi, Yukio Ohshima, Yukio Usui, Masaru Suganuma, and Kosaku Yoshida. "Binding of staphylococcal cell surface polysaccharide to human fibrinogen." Canadian Journal of Microbiology 36, no. 3 (1990): 206–10. http://dx.doi.org/10.1139/m90-035.

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The interaction between the binding site of a polysaccharide (called compact colony forming active substance (CCFAS)), obtained from the cell surface of a strain of Staphylococcus, and human fibrinogen (HF) was investigated. The CCFAS was found to bind specifically to both the Bβ and γ chains of HF at pH 7.0 and 8.0, and the Aα chain at pH 5.0. The binding of CCFAS with fibrinogen fragments obtained by digestion with plasmin were also investigated. Fragments with Mr of 55 000, 24 000, and 19 000 were the major bands precipitated by CCFAS at pH 7.0 and 8.0. Fragments with Mr of 85 000 and 75 00
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Romero-Molina, Angel Omar, Gabriel Ramirez-Garcia, Amanda Chirino-Perez, et al. "Cerebellar cognitive affective syndrome in patients with spinocerebellar ataxia type 10." PLOS ONE 20, no. 3 (2025): e0319505. https://doi.org/10.1371/journal.pone.0319505.

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Background Spinocerebellar ataxia type 10 (SCA10) is an autosomal dominant cerebellar ataxia, characterized by epilepsy, ataxic symptoms, and cognitive impairments linked to Cerebellar Cognitive Affective Syndrome (CCAS). The Cerebellar Cognitive Affective Syndrome Scale (CCAS-S) has been developed to identify CCAS across various cerebellar pathologies. Objective To determine whether patients with SCA10 exhibit CCAS using the CCAS-S, and to compare its effectiveness with the Montreal Cognitive Assessment (MoCA). A secondary objective was to evaluate the effect of demographic and clinical data
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Luo, Yun, Pengcheng Xiang, Jin Guo, and Bo Li. "Research on the Mechanism Influencing the Sustainable Development of a Contemporary Chinese Artist Village." Buildings 13, no. 6 (2023): 1432. http://dx.doi.org/10.3390/buildings13061432.

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Contemporary Chinese artist villages (CCAVs) have been developing rapidly and have become an important locus for developing cultural and creative industries, providing a strong pathway for China to achieve high-quality development and promote new urbanization. However, in practice, there are still many CCAVs that struggle with sustainable development. At present, the academic research on CCAVs mainly focuses on demonstrating the role of artist villages in promoting development in economic, social, artistic, and other fields without forming a systematic, sustainable development model or targete
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Zougmoré, Robert B., Peter Läderach, and Bruce M. Campbell. "Transforming Food Systems in Africa under Climate Change Pressure: Role of Climate-Smart Agriculture." Sustainability 13, no. 8 (2021): 4305. http://dx.doi.org/10.3390/su13084305.

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Low-income producers and consumers of food in Africa are more vulnerable to climate change, owing to their comparatively limited ability to invest in more adapted institutions and technologies under increasing climatic risks. Therefore, the way we manage our food systems needs to be urgently changed if the goal is to achieve food security and sustainable development more quickly. This review paper analyzes the nexus “climate-smart agriculture-food systems-sustainable development” in order to draw sound ways that could allow rapid transformation of food systems in the context of climate change
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Salih, Mira, Michael Young, Rishab Ramapriyan, Max Shutran, Philipp Taussky, and Christopher S. Ogilvy. "696 Optimal Management Strategy for Carotid Cavernous Aneurysm From Cost-effectiveness Perspective." Neurosurgery 70, Supplement_1 (2024): 159–60. http://dx.doi.org/10.1227/neu.0000000000002809_696.

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INTRODUCTION: Most cavernous carotid aneurysms (CCAs) are asymptomatic benign lesions; therefore, they are frequently detected during routine clinical diagnostic processes. Most providers recommend routine surveillance instead of immediate management for CCAs given a natural history with a low risk of life-threatening complications. However, the cost-effectiveness of such care and the optimal follow-up interval remains unknown. METHODS: A decision analysis study was performed utilizing a Markov model with Monte Carlo simulations to simulate patients undergoing treatment or routine surveillance
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McClure, Julie. "CCAs advocate for research funding." Crops & Soils 46, no. 3 (2013): 27. http://dx.doi.org/10.2134/cs2013-46-3-11.

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Dybdahl, David J. "Environmental risk management and CCAs." Crops & Soils 48, no. 3 (2015): 14–17. http://dx.doi.org/10.2134/cs2015-48-3-3.

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Gong, Guo Zhuo, Ji Liu, Wen Fen Yang, Yun Yun Zhou, Hai Tao Sheng, and Yan Fang. "Preparation of Coal-Based Columnar Activated Carbon for Removal of Benzene." Materials Science Forum 878 (November 2016): 101–7. http://dx.doi.org/10.4028/www.scientific.net/msf.878.101.

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In the paper, a series of coal-based columnar activated carbons (CCACs) for adsorption of benzene were prepared using a factorial experiment method. The CCACs prepared were characterized, and their adsorption capacities toward benzene were measured in a differential fixed-bed reactor. Besides, through a statistical method, the importance degree of preparation variables was studied, and the effects of preparation variables on benzene adsorption capacities of the CCACs were fully evaluated. It was found that pore structure of CCACs prepared was beneficial for benzene adsorption, but preparation
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Shilong, Xu. "Advances in Chiral Covalent Organic Frameworks for Enantiomer Separation: Synthesis, Applications, and Future Directions." Journal of Medicine and Health Science 3, no. 1 (2025): 54–62. https://doi.org/10.62517/jmhs.202505111.

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Chiral drugs, characterized by their enantioselective biological activities and pharmacological effects, necessitate precise separation techniques to ensure therapeutic efficacy and safety. This review systematically summarizes the advancements in chiral separation technologies, with a focus on the application of chiral covalent organic frameworks (CCOFs) in chromatographic enantioseparation. Traditional methods such as crystallization, asymmetric synthesis, and chromatography-based approaches are discussed, highlighting their limitations in scalability, cost, and solvent compatibility. In con
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Researcher. "TRANSFORMING CUSTOMER EXPERIENCE: THE ROLE OF AI IN CCaaS." TRANSFORMING CUSTOMER EXPERIENCE: THE ROLE OF AI IN CCaaS 15, no. 6 (2024): 211–25. https://doi.org/10.5281/zenodo.14055355.

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The evolution of Contact Center as a Service (CCaaS) represents a transformative shift in customer service operations driven by artificial intelligence and cloud technologies. This comprehensive article explores how CCaaS solutions revolutionize traditional contact center models through advanced technologies, including natural language processing, machine learning algorithms, and real-time analytics. The article examines the implementation challenges, best practices, and emerging trends in CCaaS adoption, highlighting the critical role of strategic planning, technology selection, and change ma
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Prikhodko, Veronika A., Yuri I. Sysoev, Elena V. Gerasimova, and Sergey V. Okovityi. "Novel Chromone-Containing Allylmorpholines Induce Anxiolytic-like and Sedative Effects in Adult Zebrafish." Biomedicines 10, no. 11 (2022): 2783. http://dx.doi.org/10.3390/biomedicines10112783.

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Chromone-containing allylmorpholines (CCAMs) are a novel class of compounds that have demonstrated acetyl- and butyryl-cholinesterase-inhibiting and N-methyl-D-aspartate (NMDA) receptor-blocking properties in vitro, but their in vivo pharmacological activity remains underexplored. In this work, we evaluated the psychotropic activity of five different CCAMs (1 (9a), 2 (9j), 3 (9l), 4 (33a), and 5 (33b)) using the novel tank test (NTT) and light/dark box (LDB) test in adult zebrafish. The CCAMs were screened in the NTT at a range of concentrations, and they were found to induce a dose-dependent
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Wu, Victor Y., and Richard Howarth. "Shifting partisan public opinion towards Community Choice Aggregation through outreach and awareness." PLOS ONE 18, no. 10 (2023): e0292136. http://dx.doi.org/10.1371/journal.pone.0292136.

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Community Choice Aggregation (CCA) is a rapidly expanding electricity supply model in the United States. By enabling local governments to obtain electricity for their residents, CCAs have the potential to increase the use of renewable energy while lowering costs. Recent studies have focused on how CCAs will impact renewable energy markets, since at least five more states are currently considering CCA-enabling legislation. However, little research has been done on partisan attitudes towards CCAs or how to shift public opinion to support the continued expansion of CCAs. We use a nationally repre
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Cuadros-Jiménez, Olga Elena, and Francisco Leal-Soto. "Compromiso con la clase: antecedentes socioemocionales y cognitivos." Magis, Revista Internacional de Investigación en Educación 17 (October 31, 2024): 1–24. http://dx.doi.org/10.11144/javeriana.m17.ccas.

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Este estudio descriptivo, transversal y no experimental, investigó la relación entre apoyo y recursos sociales, experiencia escolar subjetiva, autoeficacia académica y compromiso con la clase, utilizando un enfoque integrativo cognitivo y socioemocional. Participaron 1486 estudiantes chilenos de 7o a 12o grado (53.6 % mujeres), con una edad promedio de 14.9 años, de dos establecimientos privados con aportes estatales. Los estudiantes respondieron encuestas de autorreporte tipo Likert. El modelamiento de ecuaciones estructurales demostró que la experiencia escolar subjetiva es el principal fact
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Han, Bin, Yunyu Li, Zeyu Wang, Xi Gu, and Qi Zhang. "Temperature Effects on the Compressive Behaviors of Closed-Cell Copper Foams Prepared by Powder Metallurgy." Materials 14, no. 21 (2021): 6405. http://dx.doi.org/10.3390/ma14216405.

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A fabrication technology of closed-cell copper foams (CCCFs) based on powder metallurgy is proposed, by using the expanded polystyrene foams (EPS) spheres with the prescribed diameter as the space holder before sintering. The material characterization and the quasi-static compressive behaviors of both uniform and graded CCCFs at different temperatures were experimentally studied. A high temperature weakens the initial compressive modulus, plateau stress, and effective energy absorption for both uniform and graded CCCFs; meanwhile, the onset strain of densification and the maximum energy absorp
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Hoffmann-Lamplmair, Doris, Ulrike Leiss, Andreas Peyrl, et al. "QOL-24. Evaluating the diagnostic validity & predictive value of the Cerebellar Cognitive Affective Syndrome (CCAS) in pediatric posterior fossa tumour patients." Neuro-Oncology 24, Supplement_1 (2022): i138—i139. http://dx.doi.org/10.1093/neuonc/noac079.507.

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Abstract OBJECTIVE: The present study aimed to examine the extent of deficits associated with the Cerebellar Cognitive Affective Syndrome (CCAS) in patients treated for paediatric posterior fossa tumours (PFT). Furthermore, we wanted to assess its diagnostic validity and predictive value for late sequelae. METHOD: Neuropsychological test data from 56 PFT patients treated at our pediatric neuro-onocology unit (mean age at treatment: seven years; mean age at first neuropsychological examination: nine years) were examined for severity of deficits in the CCAS core domains of executive functions, v
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Okafor, Chukwuebuka C., Charles C. Ajaero, Christian N. Madu, Chinelo A. Nzekwe, Festus A. Otunomo, and Nduji N. Nixon. "Climate Change Mitigation and Adaptation in Nigeria: A Review." Sustainability 16, no. 16 (2024): 7048. http://dx.doi.org/10.3390/su16167048.

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Nigeria is one of the most vulnerable countries to climate change (CC) impact. Thus, there is a need to mitigate emission and implement strategies to adapt to the impacts of CC. This study is a review of publications on CC mitigation and/or adaptation in Nigeria. The aims are as follows: to identify commonly adopted climate change adaptation strategies (CCAS) and their determinants; and to identify the climate change mitigation strategies (CCMS) that are widely deployed to reduce emissions in Nigeria. Relevant keywords were used to search for publications in Scopus and Google Scholar. Our data
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Florescu, Cristina, Petre Ciobanu, Diana Ruxandra Hădăreanu, et al. "The Interplay between Conventional Cardiovascular Risk Factors and Health-Related Quality of Life in a Cohort of Working Young and Middle-Aged Adults: A Prospective Study." Life 12, no. 12 (2022): 2132. http://dx.doi.org/10.3390/life12122132.

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Psychosocial and work stress, socioeconomic status, and environmental health directly impact the onset and progression of cardiovascular diseases, irrespective of sex or conventional cardiovascular risk factors (cCRFs). On the other hand, the impact of cCRFs on health-related quality of life (HRQoL) is not well known, and the psychological socioeconomic environmental somatic health interaction is often neglected. Accordingly, we aimed to: (i) compare the self-reported HRQoL using the WHOQOL-BREF questionnaire between healthy subjects and those with cCRFs; and (ii) evaluate the interplay betwee
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Grützner, Julian, Janek Börner, Andreas Jäger, and Gabriele Klug. "The Small RNA-Binding Protein CcaF1 Promotes Formation of Photosynthetic Complexes in Rhodobacter sphaeroides." International Journal of Molecular Sciences 24, no. 11 (2023): 9515. http://dx.doi.org/10.3390/ijms24119515.

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In natural habitats, bacteria frequently need to adapt to changing environmental conditions. Regulation of transcription plays an important role in this process. However, riboregulation also contributes substantially to adaptation. Riboregulation often acts at the level of mRNA stability, which is determined by sRNAs, RNases, and RNA-binding proteins. We previously identified the small RNA-binding protein CcaF1, which is involved in sRNA maturation and RNA turnover in Rhodobacter sphaeroides. Rhodobacter is a facultative phototroph that can perform aerobic and anaerobic respiration, fermentati
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Tang, Bohao, Lihua Cai, Shuai Yang, Jiaxing Xu, and Yi Yu. "Evolutionary Computation for Sparse Synthesis Optimization of CCAAs: An Enhanced Whale Optimization Algorithm Method." Future Internet 14, no. 12 (2022): 347. http://dx.doi.org/10.3390/fi14120347.

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Concentric circular antenna arrays (CCAAs) can obtain better performance than other antenna arrays. However, high overhead and excessive sidelobes still make its application difficult. In this paper, we consider the sparse synthesis optimization of CCAAs. Specifically, we aim to turn off a specific number of antennas while reducing the sidelobe of CCAAs. First, we formulate an optimization problem and present the solution space. Then, we propose a novel evolutionary method for solving the optimization problem. Our proposed method introduces hybrid solution initialization, hybrid crossover meth
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Samlan, Hillel, Ellen Hawley McWhirter, and Brian A. M. Clark. "The Counseling Center Assessment of Psychological Symptoms-62 (CCAPS-62) and College Academic Outcomes." Counseling Psychologist 49, no. 6 (2021): 882–906. http://dx.doi.org/10.1177/00110000211010301.

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College students experiencing psychological distress are at risk for negative academic outcomes. The Counseling Center Assessment of Psychological Symptoms-62 (CCAPS-62) is a symptom inventory designed for and widely used in college counseling centers. However, the relationships between the CCAPS-62 and functional outcomes in the college environment have not been examined. This study examined the validity of the CCAPS-62 in predicting term grade point average (GPA) and dropout. Data from 297 first-year students at a university’s counseling center were analyzed using multiple regression to dete
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Luo, Zailei, Xueming He, Xuedong Chen, Xin Luo, and Xiaoqing Li. "Synthesis of Thinned Concentric Circular Antenna Arrays Using Modified TLBO Algorithm." International Journal of Antennas and Propagation 2015 (2015): 1–9. http://dx.doi.org/10.1155/2015/586345.

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Teaching-learning-based optimization (TLBO) algorithm is a new kind of stochastic metaheuristic algorithm which has been proven effective and powerful in many engineering optimization problems. This paper describes the application of a modified version of TLBO algorithm, MTLBO, for synthesis of thinned concentric circular antenna arrays (CCAAs). The MTLBO is adjusted for CCAA design according to the geometry arrangement of antenna elements. CCAAs with uniform interelement spacing fixed at half wavelength have been considered for thinning using MTLBO algorithm. For practical purpose, this paper
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Rhode, Michael, Tim Richter, Dirk Schroepfer, Anna Maria Manzoni, Mike Schneider, and Guillaume Laplanche. "Welding of high-entropy alloys and compositionally complex alloys—an overview." Welding in the World 65, no. 8 (2021): 1645–59. http://dx.doi.org/10.1007/s40194-021-01110-6.

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AbstractHigh-entropy alloys (HEAs) and compositionally complex alloys (CCAs) represent new classes of materials containing five or more alloying elements (concentration of each element ranging from 5 to 35 at. %). In the present study, HEAs are defined as single-phase solid solutions; CCAs contain at least two phases. The alloy concept of HEAs/CCAs is fundamentally different from most conventional alloys and promises interesting properties for industrial applications (e.g., to overcome the strength-ductility trade-off). To date, little attention has been paid to the weldability of HEAs/CCAs en
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Shao, Belinda, Lella Wirth, Kevin Ma, et al. "358 Quantifying Cognitive and Affective Dysfunction in Chiari Malformation Type I Patients With the Cerebellar Cognitive Affective Syndrome Scale and the Cerebellar Neuropsychiatric Rating Scale." Neurosurgery 70, Supplement_1 (2024): 107. http://dx.doi.org/10.1227/neu.0000000000002809_358.

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INTRODUCTION: Cognitive and affective dysfunction in Chiari Malformation Type I (CM1) patients are well-documented, but often rely on extensive neuropsychological tests. METHODS: Symptomatic CM1 patients considering surgical decompression were assessed by a board-certified neuropsychologist using the 105-point CNRS (N = 87) and the 10-task CCAS (N = 23), as well as a full neuropsychological battery (N = 24: Wechsler Full Scale IQ, Digit Span, Coding; WRAML Finger Windows; DKEFS Trail Making; verbal list learning; Grooved Pegboard). Descriptive and correlative measures were computed. RESULTS: T
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