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Rozprawy doktorskie na temat „Corneal transplantation”

Autor: Grafiati
Data publikacji: 4 czerwca 2021
Data aktualizacji: 25 lipca 2025

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Sprawdź 49 najlepszych rozpraw doktorskich naukowych na temat „Corneal transplantation”.

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1

Parekh, Mohit. "Human corneal endothelial cell culture and corneal transplantation." Doctoral thesis, Università degli studi di Padova, 2017. http://hdl.handle.net/11577/3422398.

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Cornea is the front transparent window of the eye which is responsible for optimal and clear vision. Transparency of this tissue is highly inevitable and cannot be compromised. Human cornea is made up of multiple layers out of which the posterior layer ‘endothelium’ is responsible for the transparency of the cornea. Endothelium is a monolayer of cells that allow the ions and solutes to transport from aqueous humour to the cornea and back which in turn maintains the transparency of the cornea by preserving the homeostasis between the anterior and posterior cornea. Earlier, it was observed that
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2

Brice, Sarah Louise, and sarahlbrice@gmail com. "Regional Immunosuppression for Corneal Transplantation." Flinders University. Medicine, 2010. http://catalogue.flinders.edu.au./local/adt/public/adt-SFU20100811.113448.

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Corneal transplantation is performed to restore vision or to relieve pain in patients with damaged or diseased corneas. However, approximately 40% of corneal allografts fail after 10 years. The most common cause of graft failure is irreversible immunological rejection, primarily mediated by CD4+ T cells, despite the topical application of glucocorticosteroids. The aim of this project was to investigate the anatomic site of antigen presentation during corneal transplantation in the rat, by using a lentiviral vector to express an anti-CD4 antibody fragment at potential sites of antigen presentat
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3

Arancibia, Carcamo Carolina Virgina. "Class II MHC on corneal endothelium : implications for corneal transplantation." Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.395028.

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Elzawia, Omar Rajab. "Corneal graft outcome, endothelial monolayer survival following corneal grafting : a prospective and retrospective study." Thesis, University of Bristol, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322567.

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Torres, Paulo Francisco de Ancede Aires de Sousa. "The Role of cytokines during corneal transplantation : Studies on immunopathological mechanisms of corneal rejection." Doctoral thesis, Universidade do Porto. Reitoria, 1999. http://hdl.handle.net/10216/10584.

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Torres, Paulo Francisco de Ancede Aires de Sousa. "The Role of cytokines during corneal transplantation : Studies on immunopathological mechanisms of corneal rejection." Tese, Universidade do Porto. Reitoria, 1999. http://hdl.handle.net/10216/10584.

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7

Tsang, K. "Prioritization preferences for corneal transplantation allocation in Hong Kong." Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B31972226.

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Rayner, Sandra Anne. "Tumour necrosis factor and gene transfer in corneal transplantation." Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248143.

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Winton, Helen Louise. "Inflammation related genetic variants in high risk corneal transplantation." Thesis, University of Bristol, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.617796.

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Corneal transplantation is the oldest, most common and usually the most successful type of solid tissue allograft. The acceptancc of corneal allografts compared to other categories of allografts is called immune privilege. However, some conditions rob the corneal allograft of its immune privilege and promote rejection, which remains the leading cause of corneal graft failure. The precise immune mechanism underlying graft failure is incompletely understood. While differences in human leukocyte antigen (HLA) molecules between donor and host contribute to the alloreactivity driving the donor-anti
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10

Tsang, K., and 曾光. "Prioritization preferences for corneal transplantation allocation in Hong Kong." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B31972226.

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Parker, Douglas George Anthony, and park0290@flinders edu au. "Lentivirus-mediated gene expression in corneal endothelium." Flinders University. Medicine, 2008. http://catalogue.flinders.edu.au./local/adt/public/adt-SFU20081204.094431.

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Modulation of corneal transplant rejection using gene therapy shows promise in experimental models but the most appropriate vector for gene transfer is yet to be determined. The overarching aim of the thesis was to evaluate the potential of a lentiviral vector for use in human corneal transplantation. Specific aims were: (i) to assess the ability of an HIV-1-based lentiviral vector to mediate expression of the enhanced yellow fluorescent protein (eYFP), and a model secreted protein interleukin-10 (IL10), in ovine and human corneal endothelium; and (ii) to examine the influence of lentivirus-me
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12

Katami, Mustsuo. "The extent of immunological privilege of orthotopic corneal crafts in the rat." Thesis, University of Cambridge, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.358660.

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13

Kerouedan, Christelle. "Adhesion molecule expression in corneal transplantation : a target for therapy?" Thesis, Imperial College London, 2003. http://hdl.handle.net/10044/1/11792.

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14

Duguid, I. G. M. "Prevention of corneal graft rejection with monoclonal antibodies." Thesis, University of Aberdeen, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.387460.

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This thesis aims to place corneal allograft rejection in the context of general transplantation immunology, examine the role of lymphocyte subsets in the rejection process and consider the potential application of monoclonal antibody therapy in clinical corneal graft rejection. The literature relating to the current clinical practice of corneal grafting, with particular reference to corneal allograft rejection, is reviewed in chapter 1 to present the extent of the problem. Chapter 2 then reviews the mechanisms of allograft rejection from the literature of transplantation immunology, much of wh
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15

Yang, Juan. "Universal corneal epithelial-like cells derived from human embryonic stem cells in a defined, xeno-free, and albumin-free condition for cellularization of a corneal scaffold." Thesis, University of Macau, 2018. http://umaclib3.umac.mo/record=b3953938.

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16

Liu, Lei. "Immunology of herpes simplex keratitis and its treatment by corneal transplantation." Thesis, Available from the University of Aberdeen Library and Historic Collections Digital Resources. Online version available for University member only until Sep. 7, 2010, 2009. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=33585.

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17

Comer, Richard Michael. "The effect of adenovirally derived and recombinant CTLA4-Ig protein in corneal transplantation." Thesis, Imperial College London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.401275.

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18

Seow, Wei Yang. "Development of novel non-viral vectors for use in the immunomodulation of corneal transplantation." Thesis, Imperial College London, 2011. http://hdl.handle.net/10044/1/9119.

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About 25% of corneal grafts will fail within five years (mainly due to T-cell-mediated rejection) and the ex-vivo delivery of immunomodulatory genes to the cornea is one attractive method to improve survival rates. Early efforts focused on the use of viral vectors, whose toxicity and immunogenicity remain formidable barriers. Here, we developed an arginine-rich oligopeptide featuring a novel tri-block design. Each block served a specific purpose – DNA binding, endosomal escape and cell membrane penetration – and was systematically optimised. The peptides could effectively bind and protect DNA
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19

Okanobo, Andre 1979. "Qualidade de vida dos pacientes antes e após realização de transplante penetrante de córnea = The quality of life before and after corneal transplantation." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/312762.

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Orientador: Jose Paulo Cabral de Vasconcellos<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-25T23:02:33Z (GMT). No. of bitstreams: 1 Okanobo_Andre_M.pdf: 2897473 bytes, checksum: 5bad5928ff037c8396c72781f5829cc1 (MD5) Previous issue date: 2014<br>Resumo: Avaliação da qualidade de Vida dos Pacientes Antes e Após Realização de Transplante Penetrante de Córnea. OBJETIVO Verificar o impacto do transplante de córnea sobre a qualidade de vida dos indivíduos submetidos à cirurgia no serviço de Oftalmologia HC-UNIC
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20

Ghoubay-Benalloua, Djida. "Traitement des pathologies cornéennes par thérapie cellulaire et bioingénierie tissulaire." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066445/document.

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Les agressions graves de la surface oculaire peuvent se compliquer d'ulcérations cornéennes épithéliales, de néovascularisation, d'opacification et d'inflammation chroniques, échappant à tout traitement médical. Les progrès dans la compréhension de la physiologie du renouvèlement de l'épithélium et du stroma cornéen ont permis d'introduire une approche thérapeutique, la greffe de cellules souches. L'objectif de notre étude est d'apporter une source de cellules souches cornéennes par thérapie cellulaire afin de restituer une fonction épithéliale et stromale permettant l'obtention d'une cornée c
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21

Bairaktaris, George. "Ultrastructural investigation of matrix and cell surface factors in corneal transplantation, refractive surgery and stem-cell grafting." Thesis, Lancaster University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340515.

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22

Pedemonte, Sarrias Eduard. "Tècnica de Muraine per a DMEK: anàlisi comparativa amb la tècnica estàndard." Doctoral thesis, Universitat Autònoma de Barcelona, 2017. http://hdl.handle.net/10803/405259.

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La queratoplàstia endotelial de la membrana de Descemet (DMEK) és la tècnica d'elecció actual per al tractament de l’edema corneal irreversible. Després que Melles la desenvolupés el 2006, Muraine va proposar el 2013 una tècnica alternativa per a la dissecció i implantació de l’empelt. Aquesta tècnica aportava dues novetats: la hidrodissecció amb trepanació parcial i curvatura corneal invertida del teixit donant i el plegament de l’empelt amb l'endoteli a la seva cara interna, que afavoria la protecció de l’endoteli i la tendència natural de l’empelt a desplegar-se a la cambra anterior del rec
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23

Al, Abdulsalam Najla Khaled S. "Evaluation of silk fibroin as a scaffold for cultured corneal endothelial cell implants." Thesis, Queensland University of Technology, 2018. https://eprints.qut.edu.au/122231/1/Najla%20Khaled%20S_Al%20Abdulsalam_Thesis.pdf.

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Corneal transplants are a safe and effective treatment for corneal disease, but are hampered by the limited supply and quality of donor tissue. The goal of this project was therefore to evaluate the use of membranes prepared from silk protein as a scaffold on which to grow corneal tissue substitutes in the laboratory from corneal endothelial cells.
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24

Asi, Fatema [Verfasser]. "Routine donor tomography in the eye bank as a sterile screening method for improved graft selection in corneal transplantation / Fatema Asi." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2019. http://d-nb.info/1222973782/34.

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25

Shortt, A. J. "The limbal epithelial stem cell niche and its relevance to ex-vivo culture and transplantation of corneal limbal epithelial stem cells." Thesis, University College London (University of London), 2009. http://discovery.ucl.ac.uk/18929/.

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Transplantation of ex-vivo cultured limbal epithelial cells (LEC) is an established treatment for total limbal stem cell deficiency. However, this therapy has preceded the scientific understanding of limbal epithelial stem cells (LESC), the LESC niche and the biological mechanism that underpins it. This body of work tested the hypothesis that the LESC niche has a specialised structure and that an understanding of this may lead to improvements in outcomes and understanding of this therapy. The corneal limbus was investigated using 3D confocal microscopy, scanning electron microscopy, wholemount
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26

Lima, Mário Henrique Camargos de. "Avaliação da função visual de pacientes submetidos a transplante de córnea lamelar anterior profundo utilizando dissecção com fio." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/5/5149/tde-05012016-154155/.

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Objetivo: Avaliar a função visual de pacientes submetidos a transplante lamelar anterior profundo (DALK) utilizando a dissecção com tunelizador manual e fio. Métodos: Foram incluídos 33 pacientes com ceratocone que apresentavam BCVA <= 0,60 LogMar, miopia e astigmatismo entre 8,00 e 10,00D, K central médio > 53,00D, ausência de cicatrizes, espessura corneana mínima entre 300 e 400 um. Foi feita avaliação oftalmológica completa no pré e no pós-operatório de 6 a 8 meses. Estas avaliações foram complementadas com exame topográfico da córnea, microscopia especular para avaliação da densidade das c
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27

Sá, Flávia Batista Barbosa de. "De potenciais a reais doadores: uma análise das variáveis que influenciam o processo de doação de córneas." Universidade Federal de Juiz de Fora, 2012. https://repositorio.ufjf.br/jspui/handle/ufjf/1617.

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Submitted by Renata Lopes (renatasil82@gmail.com) on 2016-05-20T17:53:34Z No. of bitstreams: 1 flaviabatistabarbosadesa.pdf: 1013858 bytes, checksum: 1e5c85e290deeb77a83c4367e5c61db1 (MD5)<br>Approved for entry into archive by Adriana Oliveira (adriana.oliveira@ufjf.edu.br) on 2016-07-02T11:27:01Z (GMT) No. of bitstreams: 1 flaviabatistabarbosadesa.pdf: 1013858 bytes, checksum: 1e5c85e290deeb77a83c4367e5c61db1 (MD5)<br>Made available in DSpace on 2016-07-02T11:27:01Z (GMT). No. of bitstreams: 1 flaviabatistabarbosadesa.pdf: 1013858 bytes, checksum: 1e5c85e290deeb77a83c4367e5c61db1 (MD5)
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Marcon, Alexandre Seminoti. "Influência da espessura corneana na acuidade visual corrigida após transplante de córnea endotelial lamelar profundo (TCELP)." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/5/5149/tde-16102014-085907/.

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Objetivo: Analisar a influência da espessura corneana central na acuidade visual (AV) corrigida após transplante de córnea endotelial lamelar profundo (TCELP). Métodos: Foram estudados de forma prospectiva 155 olhos de 127 pacientes portadores de ceratopatia bolhosa ou distrofia endotelial de Fuchs no sexto mês de pós-operatório do TCELP, entre março de 2000 e março de 2005. Foram excluídos pacientes com outras alterações oculares que justificassem baixa AV. Todos os pacientes foram submetidos à avaliação oftálmica, quando foram determinadas AV corrigida, por meio de exame refratométrico, e es
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29

Almeida, Hirlana Gomes. "Transplante de córnea no Brasil: progresso e dificuldades em 16 anos." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5149/tde-28092018-104410/.

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Introdução: As doenças da córnea são responsáveis por cerca de 5% da cegueira reversível no mundo e o transplante de córnea (TC) é importante para o tratamento dessas enfermidades. A partir de fontes de dados oficiais e públicas, foram analisados o progresso e as dificuldades relacionados ao TC no Brasil nos últimos 16 anos, bem como desigualdades regionais, gastos do Sistema Único de Saúde (SUS) e indicadores de qualidade dos bancos de tecido ocular (BTOs). Métodos: Estudo retrospectivo e analítico com dados sobre TCs e BTOs no Brasil, no período de janeiro de 2001 a dezembro de 2016, divulga
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30

Gurajada, Deepthi. "Transplantation of Human Embryonic Stem Cells to a damaged Human Cornea an in vitro study." Thesis, Södertörn University College, School of Life Sciences, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-3672.

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<p>Corneal dystrophies are commonly referred to as an congenital condition. Surgical complications are usually worse then the primary dysfunction and patients need to go through large surgical process. Only 25 % of the patients reach driving licence vision after a surgery. The aim of this study was to investigate if the application of human embryonic stem cells (hESc) could replace epithelial cells of the human cornea. Corneal markers such as cytokeratins CK3, CK15, CK19 and Pax - 6 were analysed by immunohistochemistry. HES - Cellect was used as indication of  stem cell potential of the trans
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Harfuch, Bruno [UNESP]. "Eficácia e segurança da ceratoplastia endotelial no tratamento da ceratopatia bolhosa pseudofácia e afácia: revisão sistemática e metanálise." Universidade Estadual Paulista (UNESP), 2015. http://hdl.handle.net/11449/128072.

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Made available in DSpace on 2015-10-06T13:03:08Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-02-23. Added 1 bitstream(s) on 2015-10-06T13:18:55Z : No. of bitstreams: 1 000847355.pdf: 1190450 bytes, checksum: 198ab4a47eec622beaa61096061775a2 (MD5)<br>Introdução: A córnea é uma túnica transparente responsável por 60% do poder refrativo do olho. Segundo a Organização Mundial da Saúde (OMS), doenças que afetam a transparência da córnea são responsáveis por 5,1% do total de cerca de 45 milhões de cegos. O Brasil é o país que mais realiza transplantes de córnea na América Latina. A taxa
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32

Henkel, Tassilo. "Synthese und Charakterisierung von Limbusepithel-Amnion-Transplantaten aus langzeitorgankonservierten Hornhäuten und kryokonservierten Amnionmembranen." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-63630.

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In dieser Arbeit wurden Methoden entwickelt und verglichen, um aus Corneoskleralringen langzeitorgankonservierter Hornhäute und intakten, kryokonservierten Amnionmembranen Limbusepithel-Amnion-Transplantate herzustellen. Als erfolgreichste Kultivierungsmethode stellte sich hierbei signifikant die Explantat-Technik mit nach unten gerichtetem Limbusepithel heraus. Hier konnte eine Auswachsrate von 42 % erzielt werden. Es wurde weiterhin gezeigt, dass das ausgewachsene, mehrschichtige Limbusepithel proliferationsfähige TACs (Transient Amplifying Cells) enthält. Weiterhin konnten mittels Regressi
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Santos, Marcio Alexandre Araujo Florencio dos. "Perfil dos familiares responsaveis pela autorização ou recusa a doação de corneas em Hospital de Referencia." [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311487.

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Orientador: Newton Kara-Jose<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-14T21:13:45Z (GMT). No. of bitstreams: 1 Santos_MarcioAlexandreAraujoFlorenciodos_D.pdf: 1714788 bytes, checksum: 4df269b178244131a0b3d831ea27e272 (MD5) Previous issue date: 2009<br>Resumo: Os objetivos deste estudo foram identificar o perfil epidemiológico dos familiares responsáveis pela autorização ou recusa à doação de córneas de seus parentes falecidos no Hospital de Clínicas da Universidade Estadual de Campinas; suas razões para auto
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34

Harfuch, Bruno. "Eficácia e segurança da ceratoplastia endotelial no tratamento da ceratopatia bolhosa pseudofácia e afácia : revisão sistemática e metanálise /." Botucatu, 2015. http://hdl.handle.net/11449/128072.

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Orientador: Regina Paolucci El Dib<br>Coorientador: Amélia Kamegasawa<br>Banca: Eliane Jorge<br>Banca: Tais W.<br>Resumo: Introdução: A córnea é uma túnica transparente responsável por 60% do poder refrativo do olho. Segundo a Organização Mundial da Saúde (OMS), doenças que afetam a transparência da córnea são responsáveis por 5,1% do total de cerca de 45 milhões de cegos. O Brasil é o país que mais realiza transplantes de córnea na América Latina. A taxa de perda endotelial gira em torno de 0,6/ano em pessoas normais. Essa taxa é acelerada após cirurgias oculares ou glaucoma. Essa perda, após
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35

Salauze, Marianne. "Bilan d'activité de prélevement et de greffe à l'île de La Réunion du 01-07-94 au 01-07-95." Montpellier 1, 1996. http://www.theses.fr/1996MON11060.

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Costa, Dacio Carvalho. "Uso de triancinologia subconjuntival no tratamento da rejeição endotelial do transplante de cornea." [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311490.

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Orientador: Newton Kara-Jose<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-13T21:12:46Z (GMT). No. of bitstreams: 1 Costa_DacioCarvalho_D.pdf: 11382661 bytes, checksum: a5c3e2c591c002085753bfe5397e34f3 (MD5) Previous issue date: 2009<br>Resumo: Objetivo: Comparar a eficácia da injeção subconjuntival de 20 mg de triancinolona associada a prednisolona 1% tópica com a injeção intravenosa de 500 mg de metilprednisolona associada a prednisolona 1% tópica no tratamento da rejeição endotelial de transplante de córnea. M
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37

Bray, Laura Jane. "Evaluation of fibroin-based scaffolds for ocular tissue reconstruction." Thesis, Queensland University of Technology, 2012. https://eprints.qut.edu.au/52665/1/Laura_Bray_Thesis.pdf.

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The epithelium of the corneolimbus contains stem cells for regenerating the corneal epithelium. Diseases and injuries affecting the limbus can lead to a condition known as limbal stem cell deficiency (LSCD), which results in loss of the corneal epithelium, and subsequent chronic inflammation and scarring of the ocular surface. Advances in the treatment of LSCD have been achieved through use of cultured human limbal epithelial (HLE) grafts to restore epithelial stem cells of the ocular surface. These epithelial grafts are usually produced by the ex vivo expansion of HLE cells on human donor amn
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Lima, Juvina Leonor de Souza. "Transplantes de córnea em Sergipe : caracterização dos doadores e dos receptores, de 2000 a 2009." Universidade Federal de Sergipe, 2010. https://ri.ufs.br/handle/riufs/3738.

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The situation of corneal transplants in Brazil resembles that of other countries, where it is observed an insufficient offer of cornea to meet the need of carrying out transplantations. This study aims to characterize cornea donors and patients who underwent transplantation, evaluating epidemiological data, indications from surgery, presence of rejection and length of waiting list. Method: This is an observational, transversal and descriptive study, where data were collected from all donors and receptors charts, filed at the Notification, Catchment and Distribution Center of Sergipe, from Jan
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39

Patel, Hussain Y. "Analysis of eye banking and corneal transplantation in New Zealand." 2007. http://hdl.handle.net/2292/5553.

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The series of studies comprising this thesis was developed to answer a number of key inter-related questions in regard to eye banking and corneal transplantation in New Zealand. The source and management of donor tissue procured by the New Zealand National Eye Bank (NZNEB) was analysed. Significant trends were identified with respect to donor demographics, donor procurement source, improved donor tissue processing and storage, decreased biological contamination, and increased utilization of corneal tissue. Current trends and ethnicity differences in indications for penetrating keratoplasty (PK
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40

Haydari, M. Nour. "Regenerative potential of corneal endothelium from patients with fuchs endothelial corneal dystrophy." Thèse, 2012. http://hdl.handle.net/1866/10115.

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La dystrophie cornéenne endothéliale de Fuchs (FECD, pour l’abréviation du terme anglais « Fuchs endothelial corneal dystrophy ») est une maladie de l'endothélium cornéen. Sa pathogenèse est mal connue. Aucun traitement médical n’est efficace. Le seul traitement existant est chirurgical et consiste dans le remplacement de l’endothélium pathologique par un endothélium sain provenant de cornées de la Banque des yeux. Le traitement chirurgical, en revanche, comporte 10% de rejet immunologique. Des modèles expérimentaux sont donc nécessaires afin de mieux comprendre cette maladie ainsi que pour l
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41

Bernardes, Luís Araújo Matos Caldeira. "Trends in corneal transplant indications and techniques in Coimbra, Portugal: 2011 -2016." Master's thesis, 2017. http://hdl.handle.net/10316/81896.

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Trabalho Final do Mestrado Integrado em Medicina apresentado à Faculdade de Medicina<br>Introdução: O objectivo deste estudo é determinar as recentes mudanças nas indicações para transplantes de córnea e no uso de tecido corneano em Coimbra.Métodos: os dados relativos a todos os transplantes realizados no Centro Hospitalar e Universitário de Coimbra (CHUC) entre 2011 e 2016 foram colhidos e compilados no Banco de Olhos dos CHUC. Analisámos retrospectivamente a idade, género, diagnóstico primário e técnica de transplante utilizada. Resultados: Ao longo dos 6 anos considerados, foram realizados
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42

Bostan, Cristina. "Fonctionnalité in vivo d’un endothélium cornéen reconstitué par injection de cellules endothéliales cornéennes dans la chambre antérieure d’un modèle félin." Thèse, 2015. http://hdl.handle.net/1866/16255.

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Introduction : Malgré leur état non-prolifératif in vivo, les cellules endothéliales cornéennes (CEC) peuvent être amplifiées in vitro. Leur transplantation subséquente par injection intracamérale pourrait surmonter la pénurie de tissus associée à l’allo-greffe traditionnelle – l’unique traitement définitif disponible pour les endothéliopathies cornéennes. Objectif : Évaluer la fonctionnalité d’un endothélium cornéen reconstitué par injection de CEC dans la chambre antérieure du félin. Méthodes : Les yeux droits de 16 animaux ont été opérés. Huit ont été désen
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Correia, Ana Filipa Soares. "Transplantes de Córnea de Alto Risco - Prevenção de Rejeições." Master's thesis, 2020. http://hdl.handle.net/10316/97719.

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Trabalho Final do Mestrado Integrado em Medicina apresentado à Faculdade de Medicina<br>Introdução: Os transplantes de córnea de alto risco apresentam taxas de rejeição mais elevadas e precoces devido à perda do “privilégio imunológico” habitualmente presente em doentes submetidos a transplante de córnea. Não havendo atualmente consenso sobre qual o melhor esquema imunossupressor a utilizar nestes casos, avaliámos o impacto do tacrolimus tópico na sobrevida do transplante, quando adicionado ao esquema terapêutico previamente utilizado no Serviço de Oftalmologia do Centro Hospitalar e Universit
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44

"Human umbilical cord lining epithelial cells with stem cell-like properties: an adjunct to skin regeneration." 2013. http://library.cuhk.edu.hk/record=b5549751.

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皮膚是人體最大的器官，具有多種功能，其中最重要的功能之一就是作為身體內部和外界環境之間的的保護屏障。完整地修復這一保護屏障是創傷癒合和組織再生領域的一個重要內容。本論文探討了人類臍帶被覆上皮細胞 (cord lining epithelial cells, CLECs)作為一種幹細胞來源，可用于表皮重建的潛能.<br>本論文的第二章對CLECs的體外分離和增殖進行了詳細地描述。這一類細胞具有較長的染色體端粒，較高的增殖潛能和傳代能力。同時，它們表達上皮幹細胞和多能性幹細胞的標誌性表面抗原。它們還具有多種分化潛能，包括成脂、成骨和成軟骨。然而當皮下異種移植後，它們並不會形成畸胎瘤。<br>本論文的第三章對CLECs的免疫特性進行了評估。結果顯示CLECs不但具有低免疫原性，還具有免疫調節功能。它們表達典型性的一型主要組織相容性複合體(MHC class I)，即人白細胞ABC抗原(HLA-ABC)，但不表達典型性的二型主要組織相容性複合體(MHC class II)，即人白細胞DR抗原(HLA-DR)。它們同時還表達非典型性的MHC class I, 包括人白細胞G抗原和人白細胞E 抗原(HLA-G和HLA-E), 但不表達共激分子(CD40, CD80和CD86)。此外，體外檢測還發現它們表達適度的促炎/抗炎細胞因子和大量的生長因子.<br>本論文的第四章對CLECs在表皮重建應用
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45

Chen, Hung Chi, and 陳宏吉. "Phenotypic Characterization of Human Corneas after Cultivated Oral Mucosal Epithelial Transplantation." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/66229451124838775763.

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博士<br>長庚大學<br>臨床醫學研究所<br>101<br>Recent advances in stem cell (SC) biology have led to novel application of stem cell-based therapies. Second to hematopoietic SCs, epithelial SCs are among the most studied populations. The primary source of corneal epithelium is considered to be a population of SCs, residing in the limbal region and giving rise to transient amplifying cells. Not only do SCs ensure that the corneal epithelium undergoes continual self-renewal, they are also responsible for repair and regeneration of the corneal epithelial tissue. Unfortunately, there are still limitations for
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46

Henkel, Tassilo. "Synthese und Charakterisierung von Limbusepithel-Amnion-Transplantaten aus langzeitorgankonservierten Hornhäuten und kryokonservierten Amnionmembranen." Doctoral thesis, 2010. https://tud.qucosa.de/id/qucosa%3A25456.

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In dieser Arbeit wurden Methoden entwickelt und verglichen, um aus Corneoskleralringen langzeitorgankonservierter Hornhäute und intakten, kryokonservierten Amnionmembranen Limbusepithel-Amnion-Transplantate herzustellen. Als erfolgreichste Kultivierungsmethode stellte sich hierbei signifikant die Explantat-Technik mit nach unten gerichtetem Limbusepithel heraus. Hier konnte eine Auswachsrate von 42 % erzielt werden. Es wurde weiterhin gezeigt, dass das ausgewachsene, mehrschichtige Limbusepithel proliferationsfähige TACs (Transient Amplifying Cells) enthält. Weiterhin konnten mittels Regressi
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Lin, Hsiu-Fen, and 林秀芬. "Effect of Transplantation with Cultured Human Adipose Tissue Derived Stem Cells on Rabbits Cornea RepairAfter Alkaline Chemical Burn ---- An Animal Study." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/16432366598597946283.

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碩士<br>高雄醫學大學<br>職業安全衛生研究所<br>97<br>Chemical burn is the absolute ocular emergency. It is the most severe injuries to the organ of vision with a very high percentage of unfavorable outcomes. It often causes extensive damage and results in permanent visual impairment. Recurrent epithelial erosions, symblepharon, corneal scar, corneal ulceration, severe stromal inflammation, and corneal neovascularization are common clinical complications of alkali burn .We studied the effect of cultured human adipose tissue-derived stem cells on regeneration of rabbit cornea after alkaline chemical burn. Human
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Faltýsková, Helena. "Experimentální modely přenosu kmenových buněk pro léčebné účely." Master's thesis, 2010. http://www.nusl.cz/ntk/nusl-297762.

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Experimental models of a transfer of stem cells for therapeutic purposes Abstract Stem cell therapy currently represents a standard procedure of treating a wide variety of hereditary diseases and serious injuries. Development of the most suitable way of transfer of stem cells into the patient body remains very important question concerning this type of therapy. In our experiments we used nanofiber scaffolds for stem cell cultivation and their subsequent transfer. These nanofibers were prepared by the original needleless electrospun NanospiderTM technology. Allogeneic cornea or skin graft were
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Šmeringaiová, Ingrida. "Použití endotelu rohovky a amniové membrány k transplantačním účelům." Doctoral thesis, 2020. http://www.nusl.cz/ntk/nusl-436277.

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Part I: Endothelial cells form the posterior layer of the cornea and are important for maintaining its transparency. Dysfunctional endothelium can only be restored by transplantation. The global shortage of donor corneas requires the search for alternative treatments. The preparation of the graft by tissue engineering methods is complicated by low proliferative capacity of endothelium. To date, no endothelium-specific marker has been defined and the existence of endothelial stem cells has not been confirmed yet. We have prepared a protocol for culturing endothelial cells from research-grade ti
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