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Rozprawy doktorskie na temat „Fuel delivery”

Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Duboc, B. "The effect of fuel additives on diesel fuel delivery system and combustion performance." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1455626/.

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The thesis presents an investigation of several aspects of fuel additive performance, including the effects of additives on the pump torque required to deliver high pressure fuel to engine injectors, the fuel droplet size distribution at sub-zero diesel fuel temperature, when wax formation occurs, and the ignition delay of diesel fuel combustion in an engine as well as constant volume combustion vessel. Exhaust emissions due to fuel additives were also investigated in an engine. A pump torque rig was designed and commissioned to investigate fuel additive performance at various pump speeds, fue

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2

Lang, Kevin R. 1980. "Effect of fuel properties on the first cycle fuel delivery in a Port Fuel Injected Spark Ignition Engine." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/27074.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2004.<br>Includes bibliographical references (p. 73-74).<br>Achieving robust combustion while also yielding low hydrocarbon (HC) emissions is difficult for the first cycle of cranking during the cold start of a Port Fuel Injected (PFI) Spark Ignition (SI) engine. Cold intake port wall and valve temperatures, near-atmospheric manifold pressure, and low port air velocity combine to create an adverse environment for fuel delivery - the process of injecting and vaporizing liquid fuel to create a combustible air-

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Saxton-Fox, Theresa Ann. "A constant-mass fuel delivery system for use in underwater autonomous vehicles." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/75677.

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Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2012.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 51).<br>This thesis describes the design and assembly of two constant-mass fuel tanks to be used in autonomous underwater vehicles (AUVs). The fuel tanks are part of a power supply designed to increase AUV endurance without limiting maneuverability. The fuel tanks allow AUVs to burn liquid fuel while maintaining constant buoyancy, increasing vehicle endurance by a factor of four without sacrificing mission capabilities.

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Nilsson, Daniel. "Analysis and simulation of systems for delivery of fuel straw to district heating plants /." Uppsala : Swedish Univ. of Agricultural Sciences (Sveriges lantbruksuniv.), 1999. http://epsilon.slu.se/avh/1999/91-576-5721-1.pdf.

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Al-Asad, Dawood Khaled Abdullah. "The design and evaluation of a water delivery system for evaporative cooling of a proton exchange membrane fuel cell." [College Station, Tex. : Texas A&M University, 2006. http://hdl.handle.net/1969.1/ETD-TAMU-1814.

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6

Lawrence, Jacob David. "Design and development of a high pressure ED95 fuel delivery system for a single cylinder test cell engine." Thesis, KTH, Fordonsdynamik, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-286351.

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Bio-fuels, being the primary alternative to the fossil fuels, used in the internal combustion engines are subjected to constant development. The development of alternative Ethanol Diesel (ED95) formulations at AVL Motortestcenter AB has demanded a test facility capable of evaluating the combustion quality of these specimens. A test cell capable of evaluating fuels operating on the compression ignition concept was required for this reason. The aim of this thesis is to develop a high pressure fuel delivery system for a single cylinder test cell engine. The literature review conducted offered kno

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7

Hosseini, Seyedeh Mahboobeh. "Lanthanide containing apatites| Synthesis and calorimetric studies with focus on materials for solid oxide fuel cells and drug delivery." Thesis, University of California, Davis, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=3614215.

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<p> Materials with apatite structure have attracted interest due to their versatile applications from medical diagnostics and drug delivery to energy and fuel cells. Apatites have flexible structures that can accommodate a range of elements and dopants (in terms of both size and charge) in two distinct crystallographic cation sites and consequently, exhibit fascinating defect chemistry. Recently, several different properties have been engineered into apatite structures by varying their doping schemes. However, advancement of these properties for various material applications needs a fundamenta

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8

Sutherland, Erika Susanne. "Analysis of the performance and stability of a passive recirculation loop for hydrogen delivery to a PEM fuel cell system." Digital WPI, 2011. https://digitalcommons.wpi.edu/etd-theses/443.

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Proton Exchange Membrane (PEM) fuel cells are becoming an increasingly important alternative to combustion engines as the fossil fuel reserves are depleted. Several papers have presented steady state analyses of the system, but few are known to present dynamic analysis of the flow and control of the hydrogen delivery process. This thesis presents the dynamic analysis of hydrogen delivery to a PEM fuel cell system. The hydrogen is delivered to the anode with use of an ejector for passive recirculation. The system to be studied consists of the manifolds, ejector, and pressure control valve. Mode

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9

Chandran, Davannendran. "Experimental investigation into the physico-chemical properties changes of palm biodiesel under common rail diesel engine operation for the elucidation of metal corrosion and elastomer degradation in fuel delivery system." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/35228/.

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Compatibility of fuel delivery materials (FDM) with biodiesel fuel in the fuel delivery system (FDS) under real-life common rail diesel engine (CRDE) operation poses a challenge to researchers and engine manufacturers alike. Although standard methods such as ASTM G31 and ASTM D471 for metals and elastomers, respectively, are deemed suitable for evaluating the effects of water content, total acid number (TAN) and oxidation products in biodiesel on FDM degradation, they do not resemble the actual engine operation conditions such as varying fuel pressure/temperature as well as the presence of a w

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10

Ma, Bojiang. "Cognitive spectrum access, multimedia content delivery, and full-duplex relaying in wireless networks." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/60167.

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Due to the growing number of wireless communication devices and emerging bandwidth-intensive applications, the demand of data usage is increasing rapidly. Utilizing various radio access technologies and multiple frequency bands in wireless networks can provide efficient solutions to meet the growing demand of data. These techniques are promising for the fifth generation (5G) wireless communication systems. However, to fully exploit their benefits, spectrum and spatial reuse, power saving, throughput and utility enhancement are crucial issues. In this thesis, we propose different resource alloc

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11

Curtin-Savard, Arthur. "Dose delivery uncertainty in photon beam radiotherapy." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=22856.

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It is known that slight variations in total dose delivered to the patient in external beam photon radiotherapy can significantly alter the probability of tumour control. For this reason, ICRU has recommended a goal of $ pm$5% precision in the dose delivery to the target volume. Several investigators have analyzed the degree of precision routinely achieved and have come to the conclusion that ICRU's goal can be attained, but in practice this is just barely so.<br>We have measured the degree of precision which exists in our institution by examining each step of the radiotherapy process on a coba

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12

Ankola, Dhawal Dhirajlal. "Biodegradable nanoparticles for oral delivery of Ciclosporin." Thesis, University of Strathclyde, 2010. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=12803.

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13

Gebril, Ayman Mohamed. "Development of a mucosal vaccine delivery system." Thesis, University of Strathclyde, 2013. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=24878.

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14

Somani, Sukrut. "Novel gene delivery systems for brain targeting." Thesis, University of Strathclyde, 2015. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=25815.

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Disorders of the central nervous system such as brain tumours, Alzheimer's disease, Parkinson's disease, Huntington's disease and others lead to a worst decline in the quality of life of patients. The possibility of using gene therapy for the treatment of these disorders is hindered due to the presence of blood-brain barrier and due to the lack of safe and efficacious gene delivery systems that can cross this barrier and express exogenous genes in global areas of the CNS. Various receptors such as transferrin receptors, lactoferrin receptors and low-density lipoprotein receptor-related protein

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15

Binsalamah, Ziyad. "Intramyocardial sustained delivery of Placental growth factor using nanoparticles as a vehicle for delivery in the rat infarct model." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=104785.

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Background: Acute myocardial ischemia results in scar formation with ventricular dilatation and eventually heart failure. Placental growth factor (PlGF) is reported to stimulate angiogenesis and improve cardiac function. In this study, we hypothesized that intramyocardial injection of PlGF contained in nanoparticles can be released at the site of action for an extended time period as a sustained slow-release protective mechanism that accelerates myocardial recovery in a rat model of ischemic cardiomyopathy. Methods: The study was conducted on 35 Lewis rats. The rats were randomized into the f

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16

Sabloff, Mitchell. "Characterization and intracellular delivery of lipid-drug conjugates." Thesis, McGill University, 1993. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=68255.

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Liposomes. I.e., uni- or multilamellar lipid vesicles which can carry hydrophilic material in their interior and hydrophobie materiai within their bilayers, are an interesting potential vehicle for delivery of biologically active materials. Liposomes offer several potential advantages as carriers of various types of drugs in a variety of pharmacological applications.

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17

Bolton, Katherine. "Gene delivery with amphiphilic lower generation polypropylenimine dendrimer." Thesis, University of Strathclyde, 2007. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=21936.

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In this work a novel lower generation amphiphilic polypropylenimine (PPI) dendrimer with good aqueous solubility was developed and tested as a gene delivery agent. PPI dendrimer generation 3 (DAB-16-Am) was substituted with a low level of cetyl chains (less than 5 molar percent) by reaction with 1-bromohexadecane under carefully controlled conditions. Structural characterisation was carried out using nuclear magnetic resonance spectroscopy, mass spectrometry and elemental analysis. Cetylated DAB-16 spontaneously self-assembled in an aqueous environment and in the presence of cholesterol (50% w

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18

Armstrong, Michelle. "Elucidating bioadhesive processes in nasal drug delivery systems." Thesis, University of Strathclyde, 2014. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=23193.

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Mucoadhesive formulations have been used to increase the residence time and improve bioavailability of nasal dosage forms. The exact nature of the interplay between formulations and the mucus layer has not been defined, although theories have been proposed suggesting that certain characteristics are required for optimum mucoadhesivity. This thesis presents an investigation into the effects of the properties of excipients in nasal formulations on their mucoadhesive performance. The main factors that were investigated included molecular weight, concentration, crosslinking density, charge, and vi

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19

Hume, Lisbeth R. "A comparative study of niosomes (non-ionic surfactant vesicles) and liposomes : their stability in biological environments." Thesis, University of Strathclyde, 1987. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=21490.

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Submicron sized vesicles consisting of single and double chain non-ionic surfactant mixtures were prepared by simple dispersion of surfactant dissolved in aqueous medium, or alternatively, injecting the surfactant dissolved in organic solvent into the aqueous phase. Drug entrapment values were measured by using a fluorescent marker, 5,6- Carboxyfluorescein, and drug release characteristics were evaluated in biological media (serum and plasma) as a function of surfactant composition and in the presence or absence of cholesterol. Surface charge measurements, zeta-potential, as a function of pH,

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20

Sherrard, Adam. "Maternal anthropometric factors and the risk of cesarean delivery." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=81438.

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The cesarean delivery rate in Canada has never been higher than it is now. To identify the contribution of pre-pregnancy adiposity and maternal weight gain to the risk of cesarean delivery, and evaluate to what extent these factors may account for temporal trends in primary cesarean delivery, we conducted an historical hospital-based cohort study of 63 390 deliveries at Montreal's Royal Victoria Hospital from 1978 to 2001. Pregravid adiposity and high net rate of gestational weight gain were associated with primary intrapartum cesarean delivery, and overweight and obese women with a pre

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21

Duguay, Daniel G. "Magnetically responsive polylactic acid microspheres for targetable drug delivery." Thesis, McGill University, 1991. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=22436.

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A novel magnetic Polylactic acid microsphere was developed and produced. Various magnetic materials like Iron, Nickel and Magnetite were introduced into the microspheres, at concentrations of 5 to 10% by weight. The resulting microspheres were characterized for their magnetic responsiveness with a continuous flow apparatus which simulated the vascular system. The effect of specific experimental parameters on the rate of magnetic retention were evaluated using factorial and fractional factorial designs. The observed parameters were the flow tube diameter, test fluid flow rate, magnetic field st

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22

Alsabti, Hilal. "Delivery of marrow stromal cells for angiogenesis : therapeutic implications." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=97891.

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There is tremendous enthusiasm for the utilization of angiogenesis as a therapeutic modality for atherosclerotic arterial disease. Augmentation of physiological neo-vascularization in cardiovascular disease can be achieved through different pathways. Marrow stromal cells may serve as an ideal cellular vehicle for the in vivo delivery of therapeutic proteins or production of these proteins by the cells themselves. The use of autologous marrow stromal cells is highly desirable since marrow stromal cells are abundant and available in all human of all ages and they are easy to harvest and reimplan

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23

Punjaisri, Khanyapuss. "Brand promise delivery from the customer-interface : employees' perspective." Thesis, University of Strathclyde, 2008. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=21937.

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Internal branding has recently been introduced to the literature as an enabler of the organisation's success in ensuring the delivery of the brand promise by their employees, particularly the customer-interface employees. Relatively few studies have been carried out to understand the internal branding concept from the viewpoint of employees, despite its importance. Moreover, there is only an assumption that when employees are identified with, committed and loyal to the brand, they would behave in ways that support the brand reality. Therefore, this research's aim was to explore the employees'

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Tan, Lay Ean. "A model of ageing vitreous : implications for drug delivery." Thesis, University of Strathclyde, 2010. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=22620.

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This thesis concerns the development of ex-vivo and in vivo models of vitreous synchisis, a condition that develops in the elderly. The biophysical properties of the vitreous and the effects of liquefaction on the ocular disposition of intravitreally injected substances were investigated. Conventional rheometry demonstrated that the vitreous is a non-uniform, lightly cross-linked viscoelastic solid gel, which, once destroyed, cannot be re-formed. Optical trapping was used to quantify the local viscosity with the objective of allowing repeat measurements in the same sample, a method validated u

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Bulman-Fleming, Neil. "Numerical simulations of stent-based local drug delivery : 2D geometric investigations and the evaluation of 3D designs on the basis of local delivery effectiveness." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=80000.

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Drug-eluting coronary stents have been identified as a promising means of treating in-stent restenosis. Animal models used to investigate these devices can deliver results for restenosis rates, but cannot provide accurate dose delivery information which would be very useful for refining stent geometries and apposition techniques to optimize dose delivery. In this study, a two-dimensional numerical model is constructed to explore geometrical situations of interest following stent implantation. Metallic stents with a polymer coating and biodegradable solid polymeric stents represent two d

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Jefferies, Carol. "Modelling a novel, thin strip, continuous steel caster delivery system." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=28788.

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Smooth delivery of molten metal to a chilled substrate is a key prerequisite for the development of a successful technique for thin-strip casting steel. In this work, a numerical model of a thin-strip, liquid steel delivery system was developed, validated, and used to make design predictions. The proposed slot-type planar-flow delivery system could contain a porous flow modifier, and features an extended-pool metal delivery system to the chilled substrate.<br>The steady-state, computational-fluid-dynamic (C. F. D.) model developed for this research is two-dimensional, and uses the finite-diffe

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Alsaadi, Manal Mohamed. "Non-ionic surfactant vesicles as a delivery system for cisplatin." Thesis, University of Strathclyde, 2011. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=16931.

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Cisplatin is a leading anti-cancer drug used in the treatment of various cancers. However, its clinical use is limited by its undesirable toxic side effect profile and the potential of certain tumours to be or to develop resistance to cisplatin. Encapsulation of cisplatin within a vesicular structure such as non-ionic surfactant vesicles (NIVs) was developed to overcome these limitations. Characterisation studies showed that the size and negative surface charge of cisplatin NIVs could be exploited in enhancing their uptake by the mononuclear phagocytic system present in the lungs, liver and sp

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Puig-Sellart, Mireia. "Development of non-ionic surfactant vesicles for inhaled drug delivery." Thesis, University of Strathclyde, 2016. http://digitool.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=27465.

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Rozeik, Monica Mary. "Development of a reinforced synthetic heart valve for precutaneous delivery." Thesis, University of Strathclyde, 2013. http://digitool.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=25550.

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Approximately 30% of patients with aortic stenosis over the age of 75 years are refused surgery on the grounds of technical or high risk complications. Following the onset of symptoms, prognosis is very poor if left untreated. Transcatheter aortic valves intervention (TAVI) has paved the way for valve replacement in high risk patients without the need for open heart surgery. The current market approved valves can be delivered percutaneously through the femoral artery or transapically to the beating heart, deployed over the calcified leaflets and begin functioning immediately. Complications wit

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Sharma, Gaurav. "The potential of polymeric nanoparticles for oral delivery of insulin." Thesis, University of Strathclyde, 2010. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=25746.

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Fu, Ju Yen. "Preparation and evaluation of tumour-targeted delivery systems for tocotrienol." Thesis, University of Strathclyde, 2010. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=22629.

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Tocotrienol, a group of compounds present in vitamin E, has gained much attention in recent years for its tumour suppressive properties on cancer cells. However, its therapeutic potential was hampered by the limited ability to reach tumours specifically after intravenous administration. In this study, we aim to develop a formulation of tocotrienol that could be specifically delivered to tumours upon intravenous administration through the use of a tumour-targeted delivery system. Transferrin is an iron transporter whose receptors are often over-expressed in cancer cells due to high iron demand

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Davidson, Scott. "Bio-inspired silica : development for drug delivery applications and biocompatibility." Thesis, University of Strathclyde, 2016. http://digitool.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=27559.

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The development of a drug delivery system (DDS) is essential to remedy the limitations of free drug molecules. The use of silica as a DDS over other systems (for example, liposomes) can be attributed to it being more robust and versatile. This thesis investigates bio-inspired silica (BIS) and compares it to mesoporous silica nanoparticles (MSN), which have received much attention for drug delivery applications. The BIS synthesis utilised amines to condense silica quicker than MSN, under benign conditions and without the use of hazardous chemicals. With this synthesis method drugs can be loaded

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Fakhoury, Marc. "Development of novel artificial cell microcapsule for targeted delivery of thalidomide." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=106448.

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Crohn's disease is an inflammatory disease of the intestines that may affect any part of the gastrointestinal tract from mouth to anus. It's classified as one type of inflammatory bowel disease and causes a variety of symptoms including vomiting, diarrhea and abdominal pain. The aim of this thesis is to investigate the characteristics of a new delivery method for the oral administration of thalidomide in treating Crohn's disease. The suitability of Alginate-poly-L-lysine-alginate (APA) microcapsules for oral delivery of thalidomide is first evaluated in-vitro in a simulated gastrointestinal en

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Thakur, Varun. "Planning and delivery comparison of six Linac-based stereotactic radiosurgery techniques." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=107888.

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This work presents planning and delivery comparison of linac-based SRS treatment techniques currently available for single lesion cranial SRS. In total, two dedicated SRS systems (Novalis Tx, Cyberknife) and a HI-ART TomoTherapy system with six different delivery techniques are evaluated. Four delivery techniques are evaluated on a Novalis Tx system: circular cones, dynamic conformal arcs (DCA), static non-coplanar intensity modulated radiotherapy (NCP-IMRT), and volumetric modulated arc therapy (RapidArc) techniques are compared with intensity modulation based helical Tomotherapy on the HI-

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Zeljkovic, Nada. "To inform and engage : museum websites and dynamic delivery of information /." Curtin University of Technology, School of Design, 2002. http://espace.library.curtin.edu.au:80/R/?func=dbin-jump-full&object_id=14217.

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The World Wide Web has emerged as a powerful communications medium. With the development of new technologies, organizational websites are getting bigger and more complex, using design elements such as sound and motion to engage users' attention. This project will look at how users respond to the ways designers and developers present information on the web in a dynamic form which incorporates sound and motion. The research will focus on evaluating the communicative effectiveness of websites (particularly websites with different degrees of dynamic content in them), and will see if certain ways o

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Vellore, Janarthanan Mohanraj. "Formulation of chitosan-based nanoparticles for delivery of proteins and peptides." Curtin University of Technology, School of Pharmacy, 2003. http://espace.library.curtin.edu.au:80/R/?func=dbin-jump-full&object_id=14517.

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Delivery of complex molecules such as peptides, proteins, oligonucleotides and plasmids is an intensively studied subject, which has attracted considerable medical and pharmaceutical interest. Encapsulation of these molecules with biodegradable polymers represents one way of overcoming various problems associated with the conventional delivery of macromolecules, for example instability and short biological half-life. The use of carriers made of hydrophilic polysaccharides such as chitosan, has been pursued as a promising alternative for improving the transport of biologically active macromolec

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Oun, Rabbab Hadi. "An implantable hydrogel for the delivery of cisplatin and the ex vivo neurotoxic, neuromyopathic and cardiotoxic activity of platinum-based anticancer drugs and macrocyclic drug delivery systems." Thesis, University of Strathclyde, 2015. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=25911.

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Cisplatin iscurrently aleading anticancer drug used in the treatment of various cancers. Its clinical use, however, is limited by its poor bioavailability, its undesirable toxic side effects profile and by the ability of certain tumours to develop cisplatin resistance. A method that may overcome these problems is the reversible encapsulation of cisplatin within the cavity of a macro cyclic container such as cucurbit[7]uril; a macrocycle formed by the acid condensation of glycoluril and formaldehyde, which has been shown to overcome acquired resistance in an in vivo human tumour xenograft model

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Sebak, Safaa. "Novel nanoparticles for breast cancer targeted delivery: preparation and in vitro characterization." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=86928.

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Breast cancer is the second most common type of cancer after lung cancer and the fifth most common cause of cancer death. It is by far the most widespread cancer amongst women, with an incidence rate of more than twice that of colorectal cancer and cervical cancer and about three times that of lung cancer. In this thesis, for the first time, a novel nanoparticle for effective drug delivery using the antibody trastuzumab and genipin crosslinking agent was designed and evaluated for its use in breast cancer. In vitro studies were also conducted to compare different crosslinkers in the preparati

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Muirhead, Paul. "Legal and ethical considerations of alternative health care delivery systems in Canada." Thesis, McGill University, 1998. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=21695.

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The focus of health care reform is to contribute to better patient health and maintain an equitable access to the system while at the same time achieving a more effective and efficient use of increasingly scarce health care dollars. Due to budgetary and other restraints provincial governments are either spending less on health care or are looking to change the delivery and management of the health industry.<br>How the Canadian health care system responds to the challenges depends upon the interpretation of a number of factors. Three basic factors which are linked to any health care delivery sy

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Malhotra, Meenakshi. "A multifunctional nanoparticle formulation for siRNA delivery targeting neurodegenerative diseases and cancer." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=117037.

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The thesis project focuses on the development of a novel, non-viral nanoparticle formulation for delivery of nucleic acids, drugs and other molecules. These nanoparticles were developed with an aim to administer the therapeutic molecules, non-invasively, to the targeted diseased tissue. The current thesis illustrates the design, characterization and optimization of the nanoparticles. The design of this novel nanoparticle formulation involves a series of chemical reactions on a parent polymer, chitosan, which is a cationic, biocompatible and biodegradable in nature. Chitosan was then surface gr

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Kirkpatrick, Gordon. "Evaluation of PAMAM dendrimers as delivery vehicles for platinum based anticancer drugs." Thesis, University of Strathclyde, 2012. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=16935.

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Four carboxylate terminated half generation polyamdioamine (PAMAM) dendrimers (G3.5- G6.5) were conjugated with the active components of cisplatin, {Pt(NH3)2}2+, or oxaliplatin, {Pt(R,R-dach)}2+, to form dendrimer platinate complexes. The platinum content of the cisplatin containing complexes was measured using inductively coupled plasma atomic emission spectroscopy. The number of cisplatin molecules was found to increase with increasing dendrimer size, 22 – 94, however the assumed bidentate binding mode allows for a total of 32 – 256 cisplatin moieties per dendrimer. Whilst the number of cisp

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MacLean, Fiona M. "Health informatics and the delivery of pharmaceutical care to patients with cancer." Thesis, University of Strathclyde, 2018. http://digitool.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=29532.

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This research was conducted to investigate how e-health technologies can contribute to the delivery of pharmaceutical care throughout the patient's journey and across traditional care boundaries. The hypothesis was that e-health technologies are enablers of efficient seamless delivery of pharmaceutical care. Qualitative and quantitative methods were used to examine how hospital clinical pharmacists work; to find out which toxicities were experienced by patients prescribed systemic anticancer therapy (SACT) and what their pharmaceutical care issues were; and to investigate the views of both can

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Coombs, Gemma. "The design and characterisation of multiparticulate lipidic systems for oral drug delivery." Thesis, University of Strathclyde, 2013. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=19020.

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The aim of the current research was to develop a sustained release hydrophobic matrix drug delivery system utilising extrusion spheronisation. The initial formulation supplied was Sebomin® MR 100mg capsules, an oral modified release commercial product. A technological transfer was undertaken to reproduce the Sebomin® multiparticulate product utilising lab-scale extrusion/spheronisation equipment. On successful completion, modulation of various processing parameters and the effect on the resultant granule and pellet characteristics evaluated. The potential to develop a sustained release wax mat

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Abusriwil, Abir. "Development of a nasal drug delivery system using Capsella bursa-pastoris seed mucilage." Thesis, University of Strathclyde, 2016. http://digitool.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=27401.

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Myxospermous seeds are characterised by the secretion of mucilage around the seed during germination. Capsella bursa-pastoris is an annual or perennial herbal plant of Brassicaceae family which has myxospermous seeds. This thesis studied extracted Capsella bursa-pastoris mucilage to see if it could be employed as a drug delivery system targeting the nasal cavity. Firstly, different extraction methods were used to extract the mucilage from Shepherd’s purse seeds without other contaminating components present from the seed coat. The extraction methods included the use of different solvents and t

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Duceppe, Nicolas. "Design and development of novel chitosan/hyaluronic acid-based nanocarriers for gene delivery." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=104761.

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A number of innovative techniques were developed to carry genetic material into cells, making gene therapy one of the most active fields in biotechnology. Interest in this domain is due to two factors: the therapeutic potential of the approach and lack of delivery systems which fulfil all requirements for clinical implementation. The advent of new nanotechnologies, combined with a better understanding of biological processes, enables the development of more sophisticated tools for delivery of genetic material to cells. This thesis reports on these novel nanocarriers with promising features for

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Sadl, Virginia. "Herpes virus-based packaging systems for gene delivery of the RIIA sodium channel." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=27399.

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To investigate the localization and targeting of sodium channels in neurons, an efficient means of gene delivery will need to be established. Two amplicon-based viral approaches and a recombinant whole virus approach were attempted in order to package and express RIIA sodium channel tagged with a c-myc epitope (RIIA-myc) with the ultimate purpose of developing a Herpes virus-based model system for targeting studies.<br>Immunofluorescent staining of transfected epithelial cells was carried out to demonstrate that constructs created for use in these HSV-based approaches were capable of a high le

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Brown, Pamela M. (Pamela Marie). "Development of pH-sensitive liposomes for delivery of bioactive molecules to animal cells." Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=74270.

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The work described in this thesis had as its major objective the development of improved protein-targeted, pH-sensitive liposomes for in vitro delivery of encapsulated molecules to cells. This work comprised two major facets: biophysical studies of the phase preferences and fusion-promoting abilities of different neutral phospholipids, and fluorescence-microscopic and biochemical assays of the delivery of liposome-associated molecules to CV-1 (monkey kidney fibroblast) cells in culture.<br>To study the relationship between lipid headgroup structure, physical behavior and fusion-supporting abil

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Chemali, Raja. "«In Vitro» evaluation of single walled carbon nanotubes as targeted drug delivery systems." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=110416.

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Carbon nanotubes (CNTs) have become some of the most promising drug delivery systems due to their unique properties, especially their high surface area and their ease to penetrate cells. The aim of this thesis was to render single walled carbon nanotubes (SWNTs) more biocompatible, and to test their ability to selectively deliver suitable dosages of anti-cancer drugs to αvβ3 integrins and epidermal growth factor receptor (EGFR) expressing cancer cells used as delivery targets. Those two targets are important to consider, as they are highly present on the cell membrane of several cancer cells,

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Brodeur, Marylène. "Verification of IMRT beam delivery with a ferrous sulfate gel dosimeter and MRI." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=78331.

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Intensity modulated photon beam radiation therapy often results in dynamically delivered beams with small field sizes and steep dose gradients. This defines a need for an integrating, tissue-equivalent, high resolution dosimeter. 3D ferrous sulfate gel based dosimetry involves the use of magnetic resonance (MR) images of radiosensitive paramagnetic gels. The goal of this work is to create a patient specific quality assurance (QA) procedure that links measured dosimetnc information to clinical goals.<br>The gel dosimeter system is tested through a set of simple experiments which characte

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Afkhami, Zarreh Fatemeh. "Delivery of IFNa and VEGF165b by microencapsulated cells: preparation and «in vitro» analysis." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=66849.

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ABSTRACT The pivotal role of angiogenesis in the growth and spread of all solid tumors has driven the cancer research on applying antiangiogenic factors to suppress formation of new blood vessels in order to prevent or slow tumor growth. Glycoproteins, Interferon alpha (IFNα and VEGF165b are of particular interest in this study. IFNα is a multifunctional cytokine with many physiological effects including antiangiogenesis effects. VEGF165b is a competitive antagonist of the Vascular Endothelial Growth Factor (VEGF) receptor and has been reported to successfully inhibit angioge

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