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Rozprawy doktorskie na temat „In vivo bioluminescence imaging”

Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Adams, Spencer T. Jr. "Deconstructing bioluminescence: from molecular detail to in vivo imaging." eScholarship@UMMS, 2020. https://escholarship.umassmed.edu/gsbs_diss/1064.

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Bioluminescence is the chemical production of light that results when a luciferase enzyme catalyzes the luminogenic oxidation of a small-molecule luciferin substrate. The numerous luciferases and luciferins nature has evolved can be used to illuminate biological processes, from in vitro assays to imaging processes in live animals. However, we can improve the utility of bioluminescence through modification of these enzymes and substrates. My thesis work focuses on developing reporters that expand the bioluminescent toolkit and improving our understanding of how bioluminescence works on a molecu

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Stowe, Cassandra. "Development of firefly luciferase bioluminescence for in vivo optical imaging." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10041771/.

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Firefly luciferase is ubiquitously used as a genetic reporter for the non-invasive bioluminescence imaging of small animal models. This widespread use of Firefly luciferase in vivo has been facilitated by genetic engineering producing mutants which are extremely stable at physiological conditions. In addition, the red-shifting of bioluminescence has resulted in the enhanced penetration of light emission through biological tissue. However, the use of bioluminescence in vivo is still largely limited to the tracking of single events within a model. This is due to the differential attenuation of l

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Belarbi, Essia. "Etude de la physiopathologie des infections à alphavirus arthritogènes par une approche d’imagerie in vivo." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS073.

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Les alphavirus arthritogènes de la rivière Ross (RRV) et du chikungunya (CHIKV) sont des arbovirus à l’origine de maladies inflammatoires musculosquelettiques chez l'homme. Ils sont largement distribués dans le monde et provoquent périodiquement des épidémies explosives. Les principaux signes cliniques lors d’une infection par un alphavirus arthritogène sont les myalgies, polyarthrites et arthralgies intenses pouvant persister plusieurs mois après l'infection. Les mécanismes de développement de l’infection et des manifestations persistantes sont peu connus. Pour étudier la pathogenèse de l'inf

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4

Maiwald, Gelja. "In vivo bioluminescence imaging for monitoring of siRNA mediated luciferase knockdown in tumor models." kostenfrei, 2009. http://d-nb.info/1001449320/34.

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Maiwald, Gelja. "In vivo bioluminescence imaging for monitoring of siRNA mediated luciferase knockdown in tumor models." Diss., lmu, 2010. http://nbn-resolving.de/urn:nbn:de:bvb:19-113028.

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Bolin, Celeste, Caleb Sutherland, Ken Tawara, Jim Moselhy, and Cheryl Jorcyk. "Novel mouse mammary cell lines for in vivo bioluminescence imaging (BLI) of bone metastasis." BioMed Central, 2012. http://hdl.handle.net/10150/610032.

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BACKGROUND:Tumor cell lines that can be tracked in vivo during tumorigenesis and metastasis provide vital tools for studying the specific cellular mechanisms that mediate these processes as well as investigating therapeutic targets to inhibit them. The goal of this study was to engineer imageable mouse mammary tumor cell lines with discrete propensities to metastasize to bone in vivo. Two novel luciferase expressing cell lines were developed and characterized for use in the study of breast cancer metastasis to bone in a syngeneic mouse model.RESULTS:The 4 T1.2 luc3 and 66c14 luc2 cell lines we

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7

Pinel, Karine. "Imagerie in vivo du contrôle de l’inhibition génique et de l’électroporation d’ARN." Thesis, Bordeaux 2, 2012. http://www.theses.fr/2012BOR22004/document.

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Ces travaux de thèse d’imagerie moléculaire et translationnelle proposent, sur des modèles murins, deux approches innovantes pour les thérapies géniques. La plupart des cancers sont associés à des dérégulations de l’expression génique et certains gènes sont surexprimés. L’utilisation de microARN (miARN) permet d’envisager une réduction de l’expression d’un gène spécifique mais il est nécessaire de limiter cette inhibition au tissu pathologique. L’utilisation des promoteurs thermo-inductibles couplés à un dépôt local de chaleur autorise un contrôle spatial et temporel de l’expression génique in

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Rettig, Garrett Richard. "Strategies to test nuclear localization of non-viral gene delivery vectors in vitro and in vivo." Diss., University of Iowa, 2008. https://ir.uiowa.edu/etd/212.

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Non-viral gene delivery is plagued by low transfection levels compared to viral delivery. The nuclear envelope presents a significant obstacle for non-viral vectors. A peptide-based nuclear localizing sequence has been incorporated into non-viral vectors to traverse the nuclear envelope. Here, we selected a photo-chemical method for covalently labeling the peptide onto plasmid DNA. The hypothesis of this work was to incorporate a nuclear localizing sequence into a non-viral delivery vector, demonstrate increased nuclear uptake and show a subsequent increase in transgene expression both in vitr

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9

Lin, Yuan. "In Vivo Imaging of Engraftment and Enrichment of Lentiviral Transduced Hematopoietic Bone Marrow Cells Under MGMT-P140K Mediated Selection." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1295039430.

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10

Pesnel, Sabrina. "Développement de modalités d'imagerie in vivo pour l'oncologie expérimentale." Phd thesis, Université d'Orléans, 2010. http://tel.archives-ouvertes.fr/tel-00597262.

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L'imagerie in vivo du petit animal est de plus en plus utilisée en pharmacologie pour identifier et caractériser l'activité de nouveaux agents anticancéreux.La première partie de ma thèse a consisté à développer des outils pour améliorer la quantification enbioluminescence. Une méthode, basée sur les caractéristiques spectrales des photons émis, a été établie pour corriger l'absorption tissulaire. La seconde, faisant appel aux méthodes de restauration d'images, avait pour but de corriger la diffusion pour augmenter la résolution. Dans un second temps, j'ai mis en place des modèles in vivo de t

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11

O'Farrell, Alice C. "Development of in vivo tumour models for non-invasive proof-of-principle investigation of novel therapeutic agents. Engineering and characterisation of bioluminescent cell reporter systems for in vivo analysis of anti-cancer therapy pharmacodynamics." Thesis, University of Bradford, 2011. http://hdl.handle.net/10454/5391.

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Despite significant advances in cancer treatment, clinical response remains suboptimal and there is a continued requirement for improved chemotherapeutics. The attrition rate for new therapies is high, due principally to lack of in vivo efficacy and poor pharmacodynamics. Consequently better systems are required to determine in vivo preclinical efficiency and drug-target interactions. Engineering of cancer cells to express fluorescent or bioluminescent proteins, either endogenously or under the control of specific gene promoters, and their detection by noninvasive optical imaging has the poten

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O'Farrell, Alice Claire. "Development of in vivo tumour models for non-invasive proof-of-principle investigation of novel therapeutic agents : engineering and characterisation of bioluminescent cell reporter systems for in vivo analysis of anti-cancer therapy pharmacodynamics." Thesis, University of Bradford, 2011. http://hdl.handle.net/10454/5391.

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Despite significant advances in cancer treatment, clinical response remains suboptimal and there is a continued requirement for improved chemotherapeutics. The attrition rate for new therapies is high, due principally to lack of in vivo efficacy and poor pharmacodynamics. Consequently better systems are required to determine in vivo preclinical efficiency and drug-target interactions. Engineering of cancer cells to express fluorescent or bioluminescent proteins, either endogenously or under the control of specific gene promoters, and their detection by noninvasive optical imaging has the poten

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13

Lapp, Sarah Julia. "Bioluminescence Imaging Strategies for Tissue Engineering Applications." Thesis, Virginia Tech, 2010. http://hdl.handle.net/10919/32338.

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In vitro differentiation of stem cells in biocompatible scaffolds in a bioreactor is a promising method for creating functional engineered tissue replacements suitable for implantation. Basic studies have shown that mechanical, chemical, and pharmaceutical stimuli enhance biological functionality of the replacement as often defined by parameters such as cell viability, gene expression, and protein accumulation. Most of the assays to evaluate these parameters require damage or destruction of the cell-scaffold construct. Therefore, these methods are not suitable for monitoring the development

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14

Farkasova, Katarina. "Bioluminescence imaging of luciferase transgenes in tumor metastases models." Diss., lmu, 2011. http://nbn-resolving.de/urn:nbn:de:bvb:19-139409.

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15

Gruenhagen, Jason Alan. "Bioanalytical Applications of Real-Time ATP Imaging Via Bioluminescence." Washington, D.C. : Oak Ridge, Tenn. : United States. Dept. of Energy. Office of Science ; distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2003. http://www.osti.gov/servlets/purl/822057-FTilZ3/native/.

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Thesis (Ph.D.); Submitted to Iowa State Univ., Ames, IA (US); 12 Dec 2003.<br>Published through the Information Bridge: DOE Scientific and Technical Information. "IS-T 2604" Jason Alan Gruenhagen. 12/12/2003. Report is also available in paper and microfiche from NTIS.

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16

Rose, Lisa. "Bioluminescence Imaging of Canine Osteosarcoma in an Orthotopic Murine Model." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1429269876.

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17

Campbell, Zachary Taylor. "STUDIES ON THE MECHANISM OF BACTERIAL BIOLUMINESCENCE IN VIVO AND IN VITRO." Diss., The University of Arizona, 2009. http://hdl.handle.net/10150/195376.

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Despite the importance of molecular recognition in nearly all aspects of protein function, the determinants of specificity for enzyme-substrate and protein-protein interactions are poorly understood. The majority of these complexes involving bacterial luciferase from V. harveyi have yet to be fully characterized. Luciferase catalyzes the reaction of molecular oxygen, FMNH2 and a long-chain aliphatic aldehyde yielding FMN, the corresponding carboxylic acid and blue-green light. In vivo, luciferase is thought to obtain FMNH2 following transfer from a transiently associated oxidoreductase. To

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18

Guggenheim, James A. "Multi-modal diffuse optical tomography and bioluminescence tomography system for preclinical imaging." Thesis, University of Birmingham, 2014. http://etheses.bham.ac.uk//id/eprint/5278/.

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The development, characterisation and testing of a novel all-optical, multi-modal preclinical biomedical imaging system is presented. The system aims to provide a new way of accurately visualising the spatial distribution and activity of molecular structures and processes in small animals by combining 3D bioluminescence tomography (BLT; reconstruction-based 3D imaging of internal bioluminescent reporter distributions), diffuse optical tomography (DOT; reconstruction-based imaging of optical parameter distributions) and optical surface capture techniques. The key principle of the imaging system

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Laudereau, Jean-Baptiste. "Acousto-optic imaging : challenges of in vivo imaging." Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066414/document.

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Les tissus biologiques sont des milieux fortement diffusant pour la lumière. En conséquence, les techniques d'imagerie actuelles ne permettent pas d'obtenir un contraste optique en profondeur à moins d'user d'approches invasives. L'imagerie acousto-optique (AO) est une approche couplant lumière et ultrasons (US) qui utilise les US afin de localiser l'information optique en profondeur avec une résolution millimétrique. Couplée à un échographe commercial, cette technique pourrait apporter une information complémentaire permettant d'augmenter la spécificité des US. Grâce à une détection basée sur

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20

Fernández, Vila Olaia. "Bioluminescence Imaging for the Evaluation and Development of New Biomaterials for Tissue Engineering." Doctoral thesis, Universitat Autònoma de Barcelona, 2013. http://hdl.handle.net/10803/131293.

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El desarrollo de biomateriales para ingeniería de tejido es un campo muy complejo y prolífico que en el que se combinan la ingeniería de materiales, la química, la biología celular y la medicina. Cada año se publican nuevas y prometedoras ideas que requieren de estudios in vivo e in vitro antes de realizar pruebas clínicas. Por desgracia, las condiciones in vitro son muy diferentes a las de la vida real y muchas de estas prometedoras ideas fracasan cuando son probadas en animales. El número de combinaciones posibles de tipos celulares, factores y biomateriales es inmenso, por lo que sería

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Taylor, Shelley Louise. "Quantitative bioluminescence tomography : hardware and software development for a multi-modal imaging system." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8180/.

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Bioluminescence imaging (BLI) is widely used in pre-clinical research to monitor the location and migration of different cell types, and the growth of cancerous tumours and response to treatments within murine models. However, the quantitative accuracy of the technique is limited. The position of the animal is known to affect the measured bioluminescence, with a change in position causing a change in measurement. Work presented here will address this problem, validating a free space model in a murine model to produce surface bioluminescence measurements which are independent of the position of

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22

Mezzanotte, Laura <1982&gt. "Bioanalytical applications of multicolour bioluminescence imaging: new tools for drug discovery and development." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2011. http://amsdottorato.unibo.it/3536/1/Mezzanotte_Laura_TESI.pdf.

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The subject of this thesis is multicolour bioluminescence analysis and how it can provide new tools for drug discovery and development.The mechanism of color tuning in bioluminescent reactions is not fully understood yet but it is object of intense research and several hypothesis have been generated. In the past decade key residues of the active site of the enzyme or in the surface surrounding the active site have been identified as responsible of different color emission. Anyway since bioluminescence reaction is strictly dependent from the interaction between the enzyme and its substrate D-lu

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Mezzanotte, Laura <1982&gt. "Bioanalytical applications of multicolour bioluminescence imaging: new tools for drug discovery and development." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2011. http://amsdottorato.unibo.it/3536/.

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The subject of this thesis is multicolour bioluminescence analysis and how it can provide new tools for drug discovery and development.The mechanism of color tuning in bioluminescent reactions is not fully understood yet but it is object of intense research and several hypothesis have been generated. In the past decade key residues of the active site of the enzyme or in the surface surrounding the active site have been identified as responsible of different color emission. Anyway since bioluminescence reaction is strictly dependent from the interaction between the enzyme and its substrate D-lu

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Farkašová, Katarina [Verfasser], and Eckhard [Akademischer Betreuer] Wolf. "Bioluminescence imaging of luciferase transgenes in tumor metastases models / Katarína Farkašová. Betreuer: Eckhard Wolf." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2011. http://d-nb.info/1019479302/34.

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RUSSO, MICAELA. "MULTIMODAL IMAGING IN ONCOLOGY RESEARCH: MRI AND BIOLUMINESCENCE STUDIES IN A MURINE MODEL OF PANCREATIC CANCER." Doctoral thesis, Università degli Studi di Milano, 2013. http://hdl.handle.net/2434/219127.

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Adenocarcinoma of the pancreas is one of the most aggressive human malignancies. Better models to study tumor behavior in vivo are needed for the development of more effective therapeutics. In the attempt to create clinically relevant models for studying novel treatments directed against pancreatic cancer, we defined a methodology to measure the effect of antineoplastic compounds in established human pancreatic cancer orthotopic xenografts using different luciferized pancreatic cancer cell lines (MiaPaCa-2 and Capan-1) to allow both magnetic resonance and bioluminescence imaging of animals in

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Hiler, Daniel James. "Bioluminescence Imaging of Transgene Expression at the Wholemouse Level and in the Mesencephalic Trigeminal Nucleus." Bowling Green State University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1245693947.

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Kuo, Yu-Ting. "Imaging appetite control and modulation in vivo." Thesis, Imperial College London, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.542967.

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Kotecha, Aachal. "In vivo imaging of the lamina cribrosa." Thesis, University College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406540.

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Panagiotelis, Ioannis. "In-vivo oxygen mapping using LODESR imaging." Thesis, University of Aberdeen, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367502.

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A novel imaging modality is introduced, using Radio-Frequency Longitudinally Detected Electron Spin Resonance (RF-LODESR), capable of providing qualitative and semi-quantitative information on a variety of parameters reflecting physiological function, the most significant being tissue oxygenation. Effective spin-lattice (T<sub>1e</sub>*) and spin-spin (T<sub>2e</sub>*) electronic relaxation time maps of the abdomen of living 200 g rats were generated after intravenous administration of a triarylmethyl free radical (TAM). These maps were used to evaluate oxygen distribution. Differences between

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MacKenzie, Lewis Edward. "In vivo microvascular oximetry using multispectral imaging." Thesis, University of Glasgow, 2016. http://theses.gla.ac.uk/7732/.

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This thesis describes the application of multispectral imaging to several novel oximetry applications. Chapter 1 motivates optical microvascular oximetry, outlines oxygen transport in the body, describes the theory of oximetry, and describes the challenges associated with in vivo oximetry, in particular imaging through tissue. Chapter 2 reviews various imaging techniques for quantitative in vivo oximetry of the microvasculature, including multispectral and hyperspectral imaging, photoacoustic imaging, optical coherence tomography, and laser speckle techniques. Chapter 3 describes a two-wavelen

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Lee, Li Wen. "Imaging pancreatic ß-cell in vivo using manganese-enhanced magnetic resonance imaging." Thesis, Imperial College London, 2010. http://hdl.handle.net/10044/1/5619.

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Diabetes is characterized by absolute or relative deficiency of insulin secretion by β-cells. Currently, there are no non-invasive diagnostic tools for assessing β-cell mass and function in situ. This thesis aims to develop and implement MRI techniques to image the β-cell in vivo. Calcium ion (Ca2+) entry occurs during insulin secretion and the manganese ion (Mn2+) has been used as a Ca2+ surrogate to study Ca2+ transport in β-cells. Mn2+ is also a positive T1 contrast agent and imaging [Mn2+] changes with manganese-enhanced MRI (MEMRI) may be used to monitor Ca2+ influx during insulin secreti

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Dereure, Erwan. "Quantitative analysis of bioluminescent signals in preclinical imaging." Electronic Thesis or Diss., Sorbonne université, 2024. http://www.theses.fr/2024SORUS090.

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L'imagerie par bioluminescence (BLI) est une technologie d'imagerie optique dans laquelle un organisme ou cellule vivant émet de la lumière à travers une réaction biologique substrat/enzyme sans aucune excitation lumineuse. Cette technologie, utilisée en oncologie préclinique afin de quantifier l'état des tumeurs de manière non invasive, est encore assez récente et, pour l'instant, les biologistes manquent d'outils de traitement automatisé pour améliorer la quantification des images. De plus, certains protocoles expérimentaux nécessitent l'extraction du flux de photons de plusieurs tumeurs sit

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Akkoul, Smaïl. "Filtrage et déconvolution en imagerie de bioluminescence chez le petit animal." Phd thesis, Université d'Orléans, 2010. http://tel.archives-ouvertes.fr/tel-00585392.

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Cette thèse est consacrée au traitement d'images de bioluminescence chez le petit animal. Ce type d'imagerie, bien qu'utilisé en routine pour la recherche en cancérologie par exemple, présente néanmoins des problèmes liés aux phénomènes de diffusion et d'absorption par les tissus internes à l'animal. Il s'ajoute à cela le bruit du système d'acquisition ainsi que le bruit lié aux rayonnements cosmiques. Ceci influe sur la qualité des images acquises et rend leur exploitation délicate. Le but de cette thèse est de compenser ces effets perturbateurs. Les travaux menés ont abouti à la proposition

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Stewart, Wendy Anne. "Quantitative NMR imaging and its applications in vivo." Thesis, University of British Columbia, 1985. http://hdl.handle.net/2429/26084.

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The problem of quantifying NMR parameters, measured at a field strength of 0.15 Tesla using a whole body Imaging Instrument, and their potential use in vivo, have been investigated. The spin-lattice relaxation times (T₁) of water doped with various concentrations of paramagnetic species were determined using the inversion-recovery method. Intensity was measured directly from images as a function of tau and T₁ obtained from a three parameter exponential fit of the data. The effects of varying imaging conditions on the values of T₁ obtained, were also examined. The results were compared with T₁

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Talagala, Sardha Lalith. "Aspects of NMR imaging and in vivo spectroscopy." Thesis, University of British Columbia, 1986. http://hdl.handle.net/2429/27550.

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The work described in this thesis deals mainly with aspects related to two- and three-dimensional NMR imaging. A detailed discussion on frequency-selective excitation using amplitude modulated rf pulses in relation to slice selection in NMR imaging has been presented. This includes the analysis and implementation of the method as well as illustrative experimental results. Several radiofrequency probe designs suitable for high field NMR imaging have been experimentally evaluated and their modification and construction are also described. The comparative results obtained indicate the merits a

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Enthaler, Bernd [Verfasser]. "MALDI imaging in ex-vivo skin / Bernd Enthaler." München : Verlag Dr. Hut, 2014. http://d-nb.info/1049363086/34.

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Cassidy, Maja. "Hyperpolarized Silicon Particles as In-vivo Imaging Agents." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10649.

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This thesis describes the development of hyperpolarized silicon particles as a new type of magnetic resonance imaging (MRI) agent. Silicon particles are inexpensive, non-toxic, biodegradable, targetable, and have unique physical properties that lead to extremely long nuclear polarization times. The \(^{29}Si\) nuclei are hyperpolarized by low temperature dynamic nuclear polarization using naturally occurring defects at the particle surface and directly imaged using \(^{29}Si\) MRI. The imaging window achievable is several orders of magnitude longer than other hyperpolarized imaging agents. Th

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D'Esposito, Angela Maria. "Development of three-dimensional, ex vivo optical imaging." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/1566767/.

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The ability to analyse tissue in 3-D at the mesoscopic scale (resolution: 2-50 μm) has proven essential in the study of whole specimens and individual organs. Techniques such as ex vivo magnetic resonance imaging (MRI) and X-ray computed tomography (CT) have been successful in a number of applications. Although MRI has been used to image embryo development and gene expression in 3-D, its resolution is not sufficient to discriminate between the small structures in embryos and individual organs. Furthermore, since neither MRI nor X-ray CT are optical imaging techniques, none of them is able to m

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Gibson, Vivienne Brook Liana Christina. "Developing systems for imaging immune responses in vivo." Thesis, University of Strathclyde, 2010. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=22990.

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The kinetics and dynamics of dendritic cell (DC)-T cell interactions in the lymph node (LN) are thought to be critical in initiating and regulating immune responses in both health and disease. DCs are localised in lymphoid and non-lymphoid tissues and effector and memory T cells continually migrate between both sites. However, the relationship and degree of interaction between the non-lymphoid site of tissue inflammation and the draining lymph node (DLN) remains relatively uncharacterised. This thesis aimed to develop novel in vivo model systems that would allow identifiable antigen specific T

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Hartung, Niklas. "Modelling of metastatic growth and in vivo imaging." Thesis, Aix-Marseille, 2014. http://www.theses.fr/2014AIXM4763/document.

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Un problème majeur du cancer est l'apparition de métastases, difficiles à détecter par l'imagerie médicale et qui peuvent progresser rapidement. Par le biais de la modélisation mathématique, nous espérons développer de nouveaux outils capables d'anticiper l'état métastatique d'un patient.Les deux premières parties de cette thèse sont dédiées au développement d'un tel outil, l'objectif étant sonutilisation chez l'animal voire en clinique. Dû aux variabilités intra- et inter-individuelles, nous sommes amenés à utiliser des modèles statistiques coûteux en temps de calcul.Dans la partie 1, nous ét

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Hankir, Mohammed Khair. "Investigating energy homeostasis using in vivo imaging techniques." Thesis, Imperial College London, 2010. http://hdl.handle.net/10044/1/10687.

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Obesity is a major growing cause of death with no effective long-term treatment apart from surgical procedures such as Roux-en-Y gastric bypass (RYGB). The sustained weight loss following surgery is thought to be due in part to the increased levels of circulating anorexigenic gut hormones such as peptide YY3-36 (PYY3-36). Peripheral administration of PYY3-36 suppresses appetite in rodents and man and represents a potential therapy for obesity however its effects on feeding are transient. Here I have characterized a long-lasting PYY3-36 analogue; PYY3-36 latrotoxin (PYY3-36 (LT)) which demonstr

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Rouse, Andrew Robert. "Multi-spectral confocal microendoscope for in-vivo imaging." Diss., The University of Arizona, 2004. http://hdl.handle.net/10150/280796.

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The concept of in-vivo multi-spectral confocal microscopy is introduced. A slit-scanning multi-spectral confocal microendoscope (MCME) was built to demonstrate the technique. The MCME employs a flexible fiber-optic catheter coupled to a custom built slit-scan confocal microscope fitted with a custom built imaging spectrometer. The catheter consists of a fiber-optic imaging bundle linked to a miniature objective and focus assembly. The design and performance of the miniature objective and focus assembly are discussed. The 3mm diameter catheter may be used on its own or routed though the instrum

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Boase, Nathan R. B. "Hyperbranched polymers for in vivo multimodal molecular imaging." Thesis, University of Queensland, 2015. https://eprints.qut.edu.au/96267/1/96267.pdf.

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For the development of the next generation of polymeric nanomedicines, it is crucial to gain a fundamental understanding of their behaviour and interactions with and within biological systems. Moving beyond <i>in vitro</i> models, into <i>in vivo</i> models, earlier in the development process will greatly aid in the advancement of the next generation of nanomedicines. By moving to whole animal models, our understanding of these systems progresses beyond cell targeting and uptake, to developing mechanisms for how these materials will distribute through tissues and their pharmacokinetic profile.

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Boase, Nathan, Kristofer James Thurecht, and Idriss Blakey. "Hyperbranched polymers for in vivo multimodal molecular imaging." Thesis, University of Queensland, 2015.

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For the development of the next generation of polymeric nanomedicines, it is crucial to gain a fundamental understanding of their behaviour and interactions with and within biological systems. Moving beyond in vitro models, into in vivo models, earlier in the development process will greatly aid in the advancement of the next generation of nanomedicines. By moving to whole animal models, our understanding of these systems progresses beyond cell targeting and uptake, to developing mechanisms for how these materials will distribute through tissues and their pharmacokinetic profile. This informat

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Sivaramakrishnan, Mathangi. "In vivo blood oxygenation level measurements using photoacoustic microscopy." Texas A&M University, 2003. http://hdl.handle.net/1969.1/5851.

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We investigate the possibility of extracting accurate functional information such as local blood oxygenation level using multi-wavelength photoacoustic measurements. Photoacoustic microscope is utilized to acquire images of microvasculature in smallanimal skin. Owing to endogenous optical contrast, optical spectral information obtained from spectral photoacoustic measurements are successfully inverted to yield oxygenation level in blood. Analysis of error propagation from photoacoustic measurements to inverted quantities showed minimum inversion error in the optical wavelength region of 570-60

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Nyqvist, Daniel. "In vivo imaging of islet cells and islet revascularization /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-116-6/.

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Zainon, Rafidah Binti. "Spectral Micro-CT Imaging of Ex Vivo Atherosclerotic Plaque." Thesis, University of Canterbury. Physics and Astronomy, 2012. http://hdl.handle.net/10092/7165.

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The goal of this research was to demonstrate the potential of spectral CT for the discrimination of vulnerable atherosclerotic plaques. It was proposed that spectral CT has the potential to identify the presence of specific markers for vulnerable plaques: iron deposits and lipid core. A spectral micro-CT system incorporating the latest Medipix spectroscopic photon- counting detectors was commissioned for this purpose. Using spectroscopic methods developed with this system, it was possible to distinguish the presence of iron deposits and lipid core within ex vivo atherosclerotic plaques. Athero

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Patrick, Peter Stephen. "The development of reporter genes for in vivo imaging." Thesis, University of Cambridge, 2014. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708002.

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van, Gemeren Lindsey. "Imaging agents for mutlimodal in vivo immune cell tracking." Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/6585/.

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The aim of this work was to develop tri-modal cell labels for tracking immune cells in vivo, particularly for longitudinal studies of immune cell therapies. Localisation and quantification of the cells is invaluable in determining the effectiveness of these treatments, so imaging agents for fluorescence, \(^1\)H MRI and \(^19\)F MRI were combined. Four combinations of agents in a robust scaffold were investigated: luminescent dyes and a \(^1\)H MRI contrast agent were trapped electrostatically in a silica matrix; luminescent dyes and proton MRI agents were bound to silica and gold nanoparticle

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Chan, Chi Fai. "Multi-functional upconversion nanoparticles for in vivo imaging, in vivo tumor suppression and photodynamic therapy." HKBU Institutional Repository, 2016. https://repository.hkbu.edu.hk/etd_oa/272.

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Upconversion nanoparticles (UCNPs) have been utilized for biological applications. Unlike conventional linear excitation molecules, UCNPs are excited by 980nm and emit photon in visible and near infrared region. The unique photophysical property offers superior penetration depth and lower photo-cytotoxicity. With the aid of various vectors such as target-specific peptides and photosensitizers, the UCNPs can precisely interact selectively with designated proteins (Cyclin D1 and Polo-like Kinase 1) and cancer cells so as to achieve theranostic effect. This thesis illustrated the upconversion mec

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