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Artykuły w czasopismach na temat "NT2/D1 cells"

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Mojsin, Marija, Vladanka Topalovic, Jelena Marjanovic, and Milena Stevanovic. "Quercetin and lithium chloride modulate Wnt signaling in pluripotent embryonal carcinoma NT2/D1 cells." Archives of Biological Sciences 65, no. 1 (2013): 201–9. http://dx.doi.org/10.2298/abs1301201m.

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Wnt signaling functions in numerous cellular activities such as cell fate determination, patterning, and migration in embryogenesis, apoptosis, etc. In this study, we used quercetin and lithium chloride to investigate modulations of the Wnt signaling pathway in human pluripotent embryonal carcinoma NT2/D1 cell line. First, we optimized conditions for NT2/D1 cell treatments with quercetin and lithium chloride and assessed their cytotoxic effects on the cells, cell viability and proliferation rate. Our results showed that induction of cell death by quercetin and LiCl is p53-dependent in NT2/D ce
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Bani-Yaghoub, Mahmud, Josh M. Felker, Mark A. Ozog, John F. Bechberger, and Christian C. G. Naus. "Array analysis of the genes regulated during neuronal differentiation of human embryonal cells." Biochemistry and Cell Biology 79, no. 4 (2001): 387–98. http://dx.doi.org/10.1139/o01-024.

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Recent advances in genetic technology have provided a new platform on which the simultaneous analysis of a large number of genes is possible in a rapid and efficient fashion. To assess the differential expression of human genes during neuronal differentiation, we compared the transcript profiles of undifferentiated, partially differentiated, and fully differentiated NT2/D1 cultures with cDNA expression arrays. Approximately 75 genes (13% of the gene array pool) were differentially expressed during neuronal development of NT2/D1 cells. Genes coding for pyruvate kinase M2 isozyme, clathrin assem
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Sandhu, Jagdeep K., Maria Ribecco-Lutkiewicz, and Abedelnasser Abulrob. "Molecular and Functional Characterization of Caveolae in Mixed Cultures of Human NT-2 Neurons and Astrocytes." Neuroglia 2, no. 1 (2021): 68–88. http://dx.doi.org/10.3390/neuroglia2010008.

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Caveolae are plasma membrane invaginations that are enriched in cholesterol-binding proteins called caveolins. The presence of caveolae and caveolins in mixed cultures of human neurons and glia has not been investigated. Here, we sought to determine the presence of caveolae and caveolins in human NTera-2 (NT2/D1) cells, differentiated with retinoic acid into neuron-like (NT2/N) and astrocyte-like (NT2/A) cells. We found that while caveolin-3 mRNA levels remained relatively constant, caveolin-1 and -2 levels were upregulated in NT2/A and downregulated in NT2/N. No caveolin-1 immunoreactivity wa
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DRAKULIC, DANIJELA, JELENA MARJANOVIC VICENTIC, MARIJA SCHWIRTLICH, et al. "The overexpression of SOX2 affects the migration of human teratocarcinoma cell line NT2/D1." Anais da Academia Brasileira de Ciências 87, no. 1 (2015): 389–404. http://dx.doi.org/10.1590/0001-3765201520140352.

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The altered expression of the SOX2 transcription factor is associated with oncogenic or tumor suppressor functions in human cancers. This factor regulates the migration and invasion of different cancer cells. In this study we investigated the effect of constitutive SOX2 overexpression on the migration and adhesion capacity of embryonal teratocarcinoma NT2/D1 cells derived from a metastasis of a human testicular germ cell tumor. We detected that increased SOX2 expression changed the speed, mode and path of cell migration, but not the adhesion ability of NT2/D1 cells. Additionally, we demonstrat
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Bani-Yaghoub, Mahmud, Josh M. Felker, and Christian C. G. Naus. "Human NT2/D1 cells differentiate into functional astrocytes." NeuroReport 10, no. 18 (1999): 3843–46. http://dx.doi.org/10.1097/00001756-199912160-00022.

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Eudenbach, Matthias, Jonas Busam, Caroline Bouchard, Oliver Rossbach, Kathi Zarnack, and Uta-Maria Bauer. "Assessment of PRMT6-dependent alternative splicing in pluripotent and differentiating NT2/D1 cells." Life Science Alliance 8, no. 4 (2025): e202402946. https://doi.org/10.26508/lsa.202402946.

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Protein arginine methyltransferase 6 (PRMT6) is a well-characterized epigenetic regulator that methylates histone H3 at arginine 2 (H3R2me2a) in both promoter and enhancer regions, thereby modulating transcriptional initiation. We report here that PRMT6 also regulates gene expression at the post-transcriptional level in the neural pluripotent state and during neuronal differentiation of NT2/D1 cells. PRMT6 knockout causes widespread alternative splicing changes in NT2/D1 cells, most frequently cassette exon alterations. Most of the PRMT6-dependent splicing targets are not transcriptionally aff
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Ulisse, Salvatore, Yannick Arlot-Bonnemains, Enke Baldini, et al. "Inhibition of the aurora kinases suppresses in vitro NT2-D1 cell growth and tumorigenicity." Journal of Endocrinology 204, no. 2 (2009): 135–42. http://dx.doi.org/10.1677/joe-09-0257.

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The aurora kinase family members, Aurora-A, -B, and -C (listed as AURKA, AURKB and AURKC respectively in the HUGO Database), are serine/threonine kinases involved in the regulation of chromosome segregation and cytokinesis, and alterations in their expression are associated with malignant cell transformation and genomic instability. Deregulation of the expression of the aurora kinases has been shown to occur also in testicular germ cell tumors (TGCTs) identifying them as putative anticancer therapeutic targets. We here evaluated the in vitro effects of MK-0457, an aurora kinases inhibitor, on
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Kovacevic-Grujicic, Natasa, Kazunari Yokoyama, and Milena Stevanovic. "Trans-activation of the human SOX3 promoter by MAZ in NT2/D1 cells." Archives of Biological Sciences 60, no. 3 (2008): 379–87. http://dx.doi.org/10.2298/abs0803379k.

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In this study, we examine the role of three highly conserved putative binding sites for Myc-associated zinc finger protein (MAZ) in regulation of the human SOX3 gene expression. Electrophoretic mobility shift and supershift assays indicate that complexes formed at two out of three MAZ sites of the human SOX3 promoter involve ubiquitously expressed MAZ protein. Furthermore, in cotransfection experiments we demonstrate that MAZ acts as a positive regulator of SOX3 gene transcription in both undifferentiated and RA-differentiated NT2/D1 cells. Although MAZ increased both basal and RA-induced prom
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Kanda, Yoshikazu, Kenichiro Katsura, and Sanae Hisayasu. "Milk growth factor (MGF)-induced differentiation of NT2/D1 cells." Neuroscience Letters 384, no. 3 (2005): 260–64. http://dx.doi.org/10.1016/j.neulet.2005.04.098.

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Mojsin, Marija, and Milena Stevanovic. "PBX1 and MEIS1 up-regulate SOX3 gene expression by direct interaction with a consensus binding site within the basal promoter region." Biochemical Journal 425, no. 1 (2009): 107–16. http://dx.doi.org/10.1042/bj20090694.

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Sox3/SOX3 [SRY (sex determining region Y)-box 3] is considered to be one of the earliest neural markers in vertebrates, playing a role in specifying neuronal fate. We have previously reported characterization of the SOX3 promoter and demonstrated that the general transcription factors NF-Y (nuclear factor-Y), Sp1 (specificity protein 1) and USF (upstream stimulatory factor) are involved in transcriptional regulation of SOX3 promoter activity. In the present study we provide the first evidence that the TALE (three-amino-acid loop extension) transcription factors PBX1 (pre-B-cell leukaemia homeo
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Rozprawy doktorskie na temat "NT2/D1 cells"

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Misiuta, Iwona E. "Characterization of the Dopaminergic Potential of the Human NTera2/D1 (NT2) Cell Line In Vitro." [Tampa, Fla.] : University of South Florida, 2005. http://purl.fcla.edu/fcla/etd/SFE0001184.

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Chen, Pei-Yi, and 鄭佩宜. "Activation of peroxisome proliferator-activated receptor alpha modulates NT2/D1 cell differentiation and NT2N cell degeneration by Wnt signaling pathway." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/28228045138404253603.

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碩士<br>中國醫藥大學<br>醫學研究所碩士班<br>95<br>Peroxisome proliferator-activated receptor alpha (PPARa) is a lipid- activated transcription factor playing important regulatory functions in development and metabolism. In this study, we determine the mechanism of PPARa activation on neuronal differentiation and degeneration. Using the model system of retinoic acid (RA)-induced differentiation of NT2/D1 cells into NT2N cells, NT2N cells have been demonstrated to express specific neuronal marker such as NeuroD, Mash1, Math1, and Nestin by RT-PCR, or protein expression of MAP2 and Cdk5 by Western blotting. Our
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Streszczenia konferencji na temat "NT2/D1 cells"

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Kushwaha, Ritu, Venkata Thodima, George J. Bosl, and Raju S. K. Chaganti. "Abstract 5162: MicroRNA regulation of epidermal lineage differentiation of NT2/D1 embryonal carcinoma cells." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-5162.

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Lazic, Stefan, Filip Duzanic, Danijela Stanisavljevic Ninkovic, et al. "Hypoxia affects the expression of SOX genes and induction of neural differentiation of human embryonal carcinoma NT2/D1 cells." In RAD Conference. RAD Centre, 2022. http://dx.doi.org/10.21175/rad.spr.abstr.book.2022.22.2.

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Chen, Li-Sheng, and Shu-Han Liao. "Performance Evaluation of Mobility in Non-Terrestrial Networks." In 6th International Conference on Natural Language Processing, Information Retrieval and AI. Academy & Industry Research Collaboration Center, 2025. https://doi.org/10.5121/csit.2024.150205.

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Low Earth Orbit (LEO) satellites exhibit high mobility, leading to frequent handover challenges. Addressing these handover issues is crucial for maintaining seamless and stable service connections. This paper presents a novel D1 event handover scheme that integrates Kalman filtering with artificial neural networks(ANN) to enhance handover performance in Non-Terrestrial Networks (NTN). In the proposed method, Kalman filtering provides precise UE position estimates and generates smooth trajectory predictions, which serve as inputs to a neural network. The neural network adaptively adjusts handov
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