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Rozprawy doktorskie na temat „Platinum compounds”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Lee, Daniel E. "Development of Non-Traditional Platinum Anticancer Agents: trans-Platinum Planar Amine Compounds and Polynuclear Platinum Compounds." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3809.

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Development of Non-Traditional Platinum Anticancer Agents: trans-Platinum Planar Amine Compounds and Polynuclear Platinum Compounds By Daniel E. Lee, Ph.D. A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University. Virginia Commonwealth University, 2015 Major Director: Nicholas P Farrell, Ph.D., Professor, Department of Chemistry Platinum anticancer compounds with cis geometry, similar to cisplatin, have been explored to circumvent the cisplatin resistance; however, they were not considered broadly active in c

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2

Wang, Hongli. "A study of the structural, microstructural and magnetic properties of iron-platinum and cobalt-platinum type nanoparticles." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 200 p, 2007. http://proquest.umi.com/pqdweb?did=1354136761&sid=4&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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3

Sherman, D. J. "Studies on some platinum metal compounds." Thesis, University of Oxford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.382671.

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4

Haggitt, Jane Louise. "Cluster compounds of platinum and gold." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334859.

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5

Burrows, Andrew David. "Cluster compounds of palladium and platinum." Thesis, University of Oxford, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302903.

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6

Tooze, R. P. "Organometallic compounds of platinum group metals." Thesis, Imperial College London, 1985. http://hdl.handle.net/10044/1/37880.

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7

Davis, John Christopher. "A Speciation study of the chloro-hydroxo complexes of Pt(II)." Thesis, Nelson Mandela Metropolitan University, 2009. http://hdl.handle.net/10948/1213.

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In this study a method was developed to identify and quantify platinum(II) complexes of the type [PtCl4-n(OH)n]2- and [PtCl4-n(H2O)n]2-n. Separation of the various species was achieved with the aid of a hyphenated reversed phase HPLC-ICP-MS technique coupled with an ion-pairing reagent, HMHDCl2. The adsorption of HMHD2+ onto a C-18 column was investigated by generating a series of breakthrough curves. It was found that the selectivity for high charge density anions originates from its low surface coverage relative to TBA+, which on the other hand could not separate Pt(II) complexes. The peaks

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8

Hoogervorst, Wilhelmus Johannes. "Isophthalaldimine compounds of palladium, platinum and rhodium." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2003. http://dare.uva.nl/document/69284.

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9

Ezomo, O. J. "Studies on palladium and platinum cluster compounds." Thesis, University of Oxford, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.234990.

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10

Jones, Jane Helen. "New heteroborane cluster compounds of platinum metals." Thesis, University of Leeds, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.303439.

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11

Chiffey, Andrew Francis. "Bimetallic compounds of palladium, platinum and gold." Thesis, University of Southampton, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294602.

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12

Kelly, P. F. "Sulphur-nitrogen compounds of platinum and palladium." Thesis, Imperial College London, 1987. http://hdl.handle.net/10044/1/46826.

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13

Taylor, Lynne M. "Interactions of platinum compounds with heterocyclic bases." Thesis, Robert Gordon University, 1990. http://hdl.handle.net/10059/2356.

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It is generally accepted that platinum antitumour drugs bind, preferentially, to Guanine N7 in DNA. Thus the kinetics of formation and the energetics of dissociation of platinum-nitrogen bonding have been investigated, using simple model bases, namely pyridine. pyrimidine. purine and some derivatives. Six complexes of the type cis-PtCl2L2, where L is a N-heterocycle, have been successfully prepared and characterized. The kinetics of the reaction between K2PtCl4 and the N-heterocyclic bases in aqueous solution have beeD studied. This was best achieved by pre-aquating the PtCl4(2-) and measuring

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14

Li, Jian-Jun. "Platinum(II) hydroxo, oxo, amido, imido and hydrazido complexes /." free to MU campus, to others for purchase, 1996. http://wwwlib.umi.com/cr/mo/fullcit?p9720553.

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15

Scherlin, Freddy. "Synthesis and characterization of bimetallic platinum-thallium compounds." Thesis, Linköping University, The Department of Physics, Chemistry and Biology, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-15403.

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<p>The solid bimetallic compounds TtPt(CN)<sub>4</sub>(ClO<sub>4</sub>) and TtPt(CN)<sub>4</sub>(NO<sub>3</sub>) have been prepared by reactions between tetracyanoplatinate complex [Pt(CN)4]2- and aqueous solutions of Tl(ClO<sub>4</sub>)<sub>3</sub> and Tl(NO<sub>3</sub>)<sub>3</sub>, respectively. The elemental analysis (N, C, H, Tl) of the compound has been carried out. The results of the analysis are reasonably consistent with the above compositions of the compounds. The bimetallic compounds have been characterized by IR and Raman spectroscopy as well as X-ray diffraction. IR and Raman spec

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16

Tarlton, Stephen Vijay. "Low oxidation state compounds of palladium and platinum." Thesis, Imperial College London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300855.

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17

Watson, Michael John. "Cluster compounds of gold and the platinum metals." Thesis, University of Oxford, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.279996.

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18

Hallam, Malcolm Francis. "Synthetic and spectroscopic studies on heterometallic clusters of platinum." Thesis, University of Oxford, 1986. http://ora.ox.ac.uk/objects/uuid:a74b7c1b-4201-46cf-89aa-92d3f7160a9a.

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This Thesis describes the synthesis and structural characterisation of a range of heterometallic cluster compounds of platinum. Chapter 1 reviews the current knowledge in this area and gives examples of the kinds of cluster compounds which have been characterised, with some emphasis on their mode of synthesis and their structural and spectroscopic characterisation. The structures of the cluster compounds are rationalised in terms of the triangular Pt<sub>3</sub> unit which dominates the cluster chemistry of platinum. The bonding in the simplest triplatinum cluster compounds is analysed and is

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19

Tong, Wai-yip, and 唐煒燁. "Luminescent platinum(II) complexes containing dianionic tetradentate ligands having mixed oxygen, nitrogen and carbon donor atoms and platinum(II)-containing phosphorescent polymers : synthesis, photophysical properties and material applications." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/198829.

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20

Myburgh, Jolanda. "Synthesis and characterization of novel platinum complexes : their anticancer behaviour." Thesis, Nelson Mandela Metropolitan University, 2009. http://hdl.handle.net/10948/d1018621.

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In this dissertation novel non-leaving groups were employed to synthesize platinum complexes which can contribute to the understanding or improvement of anticancer action. These complexes basically consist of (NS)-chelate and amineplatinum complexes. Bidentate (NS)-donor ligands were used as non-leaving ligands in the syntheses of platinum(II) complexes with iodide, chloride, bromide and oxalate anions as leaving groups. These complexes were synthesized and studied since many questions regarding the interaction of sulfur donors and platinum still exists. These relate to thermodynamic and kinet

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21

Reams, Patrick William. "Solid-state N.M.R. studies of platinum and tin compounds." Thesis, Durham University, 1986. http://etheses.dur.ac.uk/6793/.

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High-resolution solid-state N.M.R. studies of dilute spins are now possible using cross-polarisation and MAS techniques. A systematic evaluation has been undertaken to determine their applicability to spin-½ metal nuclei, in particular (^195)Pt and (^119)Sn. In addition, an extensive (^13)C and (^31)p solid-state N.M.R. study has been carried out on a selection of Pt(II) complexes, supplying information on isotropic (scalar) coupling constants and shielding anisotropy. The majority of (^119)Sn and (^195)Pt spectra exhibit a multitude of spinning sidebands due to the large shielding anisotropy

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22

Savage, Paul David. "Organometallic compounds of rhenium and the platinum group metals." Thesis, Imperial College London, 1987. http://hdl.handle.net/10044/1/46494.

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23

Figueiredo, Marta C. "Electrocatalytic reduction of nitrogen containing compounds on platinum surfaces." Doctoral thesis, Universidad de Alicante, 2012. http://hdl.handle.net/10045/26516.

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24

Torabi, Ali Asghar. "X-ray studies on Pt/Re and other compounds." Thesis, University of Glasgow, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307196.

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25

Luedtke, Avery T. "Synthesis, structure, and reactivity of five-coordinate platinum(IV) complexes /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/11565.

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26

Wardle, R. W. M. "Synthetic and structural studies in platinum cluster chemistry." Thesis, University of Oxford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355822.

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27

Wan, Kam-to. "Syntheses and photochemistry of monomeric platinum (II) complexes /." [Hong Kong : University of Hong Kong], 1990. http://sunzi.lib.hku.hk/hkuto/record.jsp?B12757949.

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28

Wicks, Joseph Leslie Michael. "Routes to mixed metal compounds of the platinum group : metal σ-acetylide complexes and platinum clusters". Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620495.

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29

Bojczuk, M. "Carbonyl exhange mechanisms in transition metal compounds." Thesis, University of Kent, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.372765.

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30

Chan, Hoi-yiu. "Design and synthesis of luminescent mono- and dinuclear platinum(II) alkynyl terpyridine complexes : from photophysics to aggregation and self-assembly /." Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36929232.

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31

Roden, M. D. "Synthesis and characterisation of some novel low-coordinate phosphorus compounds containing bulky electron-withdrawing substituents." Thesis, Durham University, 1998. http://etheses.dur.ac.uk/4692/.

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The synthesis of several new phosphorus derivatives including new monophosphanes of the type RPX(_2) (X = F, CI and H), containing either the Fluoromes [2,4,6-(CF(_3))(_3)C(_6)H(_2)] or Fluoroxyl [2,6-(CF(_3))(_2)C(_6)H(_3)] group has been carried out successfully. The synthesis of a number of Cis-Platin analogous has been facilitated by the reaction of these new monophosphanes with a platinum dimer [(PCl(_2)(Pet(_3))(_2)](_2). These compounds are of the type PtCl(_2)(Pet(_3))RPX(_2) (X = CI, H and F, R = 2,6- bis(trifluoromethyl)phenyl). These compounds have shown an interesting correlation b

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32

Yu, Ka-lai. "Design and synthesis of luminescent homo- and heterometallic complexes of Platinum(II) /." Hong Kong : University of Hong Kong, 1999. http://sunzi.lib.hku.hk/hkuto/record.jsp?B21020449.

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33

Chan, Lai-ping. "Syntheses, photophysics and photochemistry of polynuclear homo- and hetero-metallic complexes of platinum (II) acetylides /." [Hong Kong : University of Hong Kong], 1994. http://sunzi.lib.hku.hk/hkuto/record.jsp?B13857666.

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34

Bouwer, Yolanda. "Novel aspects of platinum-amine coordination compounds: their chemistry and anticancer application." Thesis, Nelson Mandela Metropolitan University, 2008. http://hdl.handle.net/10948/d1021052.

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The aim in this thesis, was to synthesize novel platinum coordination compounds, in order to develop compounds with improved anticancer action which could lead to an improved understanding of the mechanism by which they operate and at the same time, improve synthetic methods for their products. The initial work included the development of a novel synthetic method for 1R,2R-diaminocyclohexaneoxalato-platinum(II) (oxaliplatin), by using an essentially non-aqueous solvent medium and direct ligand exchange at elevated temperatures. This was done by a study of the kinetics of the reaction in a vari

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35

Kui, Chi-fai. "Non-covalent weak interactions in group IV, PT(II) and AU(I) organometallic complexes synthesis, structures and properties /." Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/B32021331.

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36

Oosthuizen, Lukas Marthinus. "New platinum coordination compounds : their synthesis, characterization and anticancer application." Thesis, Nelson Mandela Metropolitan University, 2009. http://hdl.handle.net/10948/d1018795.

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The aim of this thesis was to investigate the properties of novel platinum compounds with possible potential as anticancer agents, and to determine how their behaviour could lead to a better understanding of the chemistry involved. The final criteria were improvement of their anticancer behaviour. Since many questions are still unanswered as to the role of sulfur in anticancer action, studies were undertaken to synthesize novel platinum(II) complexes having non-leaving groups consisting of a combination of an aromatic nitrogen and thioetherial sulfur capable of forming a five membered ring upo

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37

尹錦濤 and Kam-to Wan. "Syntheses and photochemistry of monomeric platinum (II) complexes." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1990. http://hub.hku.hk/bib/B31209476.

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38

Liu, Li. "The chemistry of luminescent mercury (II) alkynyl complexes and their platinum (II) and gold (I) counterparts." HKBU Institutional Repository, 2005. http://repository.hkbu.edu.hk/etd_ra/627.

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39

Kotadia, Nayna. "A Study on the Protein Interaction with Different Platinum Compounds." TopSCHOLAR®, 2008. http://digitalcommons.wku.edu/theses/8.

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Since the discovery of anti-tumor activity of cisplatin in 1960, significant progress has been made in treating metastatic or advanced cancer with cisplatin and platinum compounds. Platinum compounds covalently bind to DNA and disrupt DNA function. They are also known to bind with amino acids like methionine, histidine and cysteine to form cisplatin-protein adducts which are responsible for most of its cytotoxicity and side effects. Recent articles on cisplatin-protein have shown that adding bulky adjuncts to cisplatin or using different platinum compounds varies the degree and extent of react

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40

Anderson, Bernard Marshall. "A study of polymeric platinum (II) compounds and nanoscale materials." Diss., Montana State University, 2004. http://etd.lib.montana.edu/etd/2004/anderson/AndersonB0504.pdf.

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41

Duin, Marcel Adrianus. "Nucleophilic and electrophilic platinum compounds for C-H bond activation." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2004. http://dare.uva.nl/document/75218.

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42

Robey, Stephanie. "Reactions of Platinum(II) Compounds with Selenium Containing Amino Acids." TopSCHOLAR®, 2013. http://digitalcommons.wku.edu/theses/1252.

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Platinum(II) anticancer medications essentially react with DNA forming kinks inthe double helix of DNA and causing apoptosis. It has also been noted that theseanticancer medications react with methionine and cysteine in the body. With the new discoveries of selenium containing amino acids including selenomethionine and selenocysteine, new research is ongoing to see what types of products can be formed from these amino acids. Our research reacts [Pt(Met-S,N)Cl2] 2+ with selenomethionine to determine what types of products are produced. Monochelates including [Pt(SeMet-Se,N)Cl2] 2+ have formed t

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43

Hill, Christopher M. "The synthesis of novel cluster compounds of palladium and platinum." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334864.

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44

Kabolizadeh, Peyman. "Mechanisms of Accumulation and Biological Consequences of Polynuclear Platinum Compounds." VCU Scholars Compass, 2007. http://hdl.handle.net/10156/1913.

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45

Basu, Sayanti. "Synthesis and catalytic applications of new acceptor platinum alkyl cations." Laramie, Wyo. : University of Wyoming, 2009. http://proquest.umi.com/pqdweb?did=1939365871&sid=1&Fmt=2&clientId=18949&RQT=309&VName=PQD.

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46

Shum, Yuen-ting, and 岑婉婷. "Functionalized platinum (II) and gold (I) acetylide complexes: structural and spectroscopic properties andanticancer activities." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B38639865.

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47

Shum, Yuen-ting. "Functionalized platinum (II) and gold (I) acetylide complexes structural and spectroscopic properties and anticancer activities /." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38639865.

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48

Chantson, Janine. "Platinum (II) complexes of heteroaromatic derivatives." Pretoria : [s.n.], 2002. http://upetd.up.ac.za/thesis/available/etd-08012005-143742/.

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49

Kwok, Chi-chung. "Functional light-emitting materials of platinum, zinc and boron for organic optoelectronic devices." Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/B34617693.

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50

俞嘉麗 and Ka-lai Yu. "Design and synthesis of luminescent homo- and heterometallic complexesof Platinum(II)." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31239699.

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