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1
Taylor, Richard. "Finite element modelling of three dimensional fluid-structure interaction." Thesis, Swansea University, 2013. https://cronfa.swan.ac.uk/Record/cronfa42308.
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This work is focused on the numerical modelling of fluid-structure interaction in three dimensions. Both internal and external laminar flow around flexible bodies are considered. The fluid flow simulated is based on the incompressible Navier-Stokes equations and the general focus is on laminar Newtonian flow. The streamline upwind/ pressure stabilising Petrov-Galerkin (SUPG/PSPG) method is employed to achieve a stable low order finite element discretisation of the fluid, while the solid is discretised spatially by a standard Galerkin finite element approach. The behavior of the solid is governed by Neo-Hooke elasticity. For temporal discretisation the discrete implicit generalised-alpha method is employed for both the fluid and the solid domains. The motion of the fluid mesh is solved using an arbitrary Lagrangian-Eulerian (ALE) scheme employing a nonlinear pseudo-elastic mesh update method. The fluid-solid interface is modelled using a finite element interpolation method that allows for non-matching meshes and satisfies the required conservation laws. The resulting sets of fully implicit strongly coupled nonlinear equations are then decomposed into a general framework consisting of fluid, interface and solid domains. These equations are then solved using different solution techniques consisting of strongly coupled monolithic Newton and block Gauss-Seidel methods as well as a weakly coupled novel staggered scheme. These solvers are employed to solve a number of three dimensional numerical examples consisting of: External flow: o a soft elastic beam fixed at both ends o a thin cantilever plate.
2
Lemmon, Jack David Jr. "Three-dimensional computational modeling of fluid-structure interaction : study of diastolic function in a thin-walled left heart model." Diss., Georgia Institute of Technology, 1998. http://hdl.handle.net/1853/15912.
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Hong, Say Yenh. "Fluid structure interaction modeling of pulsatile blood flow in serial pulmonary artery stenoses." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112571.
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Motivated by the physiological phenomena of collapse and flow limitation for a serial pulmonary artery stenosis, we investigated the three-dimensional influence of spatial configuration on the wall motion and hemodynamic. Our numerical study focused on the effect of two geometrical parameters: the relative distance and the angular orientation between the two stenoses. The collapse of a compliant arterial stenosis may cause flow choking, which would limit the flow reserve to major vital vascular beds such as the lungs, potentially leading to a lethal ventilation-perfusion mismatch. Flow through a stenotic vessel is known to produce flow separation downstream of the throat. The eccentricity of a stenosis leads to asymmetric flow where the high velocity jets impinge on the sidewall, thereby inducing significant dissipation. The additional viscous dissipation causes a higher pressure drop for a flow through a stenotic vessel, than in a straight compliant vessel. It is likely that some particular morphology would have a higher vulnerability to the fluid induced instability of buckling (divergence), under physiological pulsatile flow. It was found that fluid pressure distribution have substantial implication for the downstream wall motion, under conditions of strong coupling between nonlinear vessel geometries, and their corresponding asymmetric flow. The three-dimensional fluid structure interaction problem is solved numerically by a finite element method based on the Arbitrary Lagrangian Eulerian formulation, a natural approach to deal with the moving interface between the flow and vessel. The findings of this investigation reveal that the closeness between stenoses is a substantial indication of wall collapse at the downstream end. Moreover, the results suggest a close link between the initial angular orientation of the distal stenosis (i.e. the constriction direction) and the subsequent wall motion at the downstream end. For cases showing evidence of preferential direction of wall motion, it was found that the constricted side underwent greater cumulative displacement than the straight side, suggestive of significant wall collapse.
4
Obando, Vallejos Benjamin. "Mathematical models for the study of granular fluids." Thesis, Université de Lorraine, 2018. http://www.theses.fr/2018LORR0274/document.
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Cette thèse vise à obtenir et à développer des modèles mathématiques pour comprendre certains aspects de la dynamique des fluides granulaires hétérogènes. Plus précisément, le résultat attendu consiste à développer trois modèles. Nous supposons dans un premier temps que la dynamique du matériau granulaire est modélisée à l’aide d’une approche fondée sur la théorie du mélange. D’autre part, pour les deux modèles restant, nous considérons que le fluide granulaire est modélisé à l’aide d’une approche multiphase associant des structures et des fluides rigides. Plus exactement : • Dans le premier modèle, nous avons obtenu un ensemble d’équations basées sur la théorie du mélange en utilisant des outils d’homogénéisation et une procédure thermodynamique. Ces équations reflètent deux propriétés essentielles des fluides granulaires : la nature visqueuse du fluide interstitiel et un comportement de type Coulomb de la composante granulaire. Avec nos équations, nous étudions le problème de Couette entre deux cylindres infinis d’un écoulement hétérogène granulaire dense, composé d’un fluide newtonien et d’une composante solide. • Dans le deuxième modèle, nous considérons le mouvement d’un corps rigide dans un matériau viscoplastique. Les équations 3D de Bingham modélisent ce matériau et les lois de Newton régissent le déplacement du corps rigide. Notre résultat principal est d’établir l’existence d’une solution faible pour le système correspondant. • Dans le troisième modèle, nous considérons le mouvement d’un corps rigide conducteur thermique parfait dans un fluide newtonien conducteur de la chaleur. Les équations 3D de Fourier-Navier-Stokes modélisent le fluide, tandis que les lois de Newton et l’équilibre de l’énergie interne modélisent le déplacement du corps rigide. Notre principal objectif dans cette partie est de prouver l’existence d’une solution faible pour le système correspondant. La formulation faible est composée de l’équilibre entre la quantité du mouvement et l’équation de l’énergie totale, qui inclut la pression du fluide, et implique une limite libre due au mouvement du corps rigide. Pour obtenir une pression intégrable, nous considérons une condition au limite de glissement de Navier pour la limite extérieure et l’interface mutuelle<br>This Ph.D. thesis aims to obtain and to develop some mathematical models to understand some aspects of the dynamics of heterogeneous granular fluids. More precisely, the expected result is to develop three models, one where the dynamics of the granular material is modeled using a mixture theory approach, and the other two, where we consider the granular fluid is modeled using a multiphase approach involving rigid structures and fluids. More precisely : • In the first model, we obtained a set of equations based on the mixture theory using homogenization tools and a thermodynamic procedure. These equations reflect two essential properties of granular fluids : the viscous nature of the interstitial fluid and a Coulomb-type of behavior of the granular component. With our equations, we study the problem of a dense granular heterogeneous flow, composed by a Newtonian fluid and a solid component in the setting of the Couette flow between two infinite cylinders. • In the second model, we consider the motion of a rigid body in a viscoplastic material. The 3D Bingham equations model this material, and the Newton laws govern the displacement of the rigid body. Our main result is the existence of a weak solution for the corresponding system. • In the third model, we consider the motion of a perfect heat conductor rigid body in a heat conducting Newtonian fluid. The 3D Fourier-Navier-Stokes equations model the fluid, and the Newton laws and the balance of internal energy model the rigid body. Our main result is the existence of a weak solution for the corresponding system. The weak formulation is composed by the balance of momentum and the balance of total energy equation which includes the pressure of the fluid, and it involves a free boundary (due to the motion of the rigid body). To obtain an integrable pressure, we consider a Navier slip boundary condition for the outer boundary and the mutual interface
5
Romanel, Celso 1952. "DYNAMIC SOIL-STRUCTURE INTERACTION IN A LAYERED MEDIUM." Thesis, The University of Arizona, 1987. http://hdl.handle.net/10150/276511.
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The most popular method in dynamic soil-structure interaction analysis is the finite element method. The versatility in problems involving different materials and complex geometries is its main advantage, yet FEM can not simulate unbounded domains completely. A hybrid method is proposed in this research, which models the near field (structure and surrounding soil) by finite elements and the far field by a continuum approach. The system is excited by monochromatic body waves (P and SV) propagating with oblique incidence and harmonic time dependence. The far field problem is solved using Thomson-Haskell formulation associated with the delta matrix technique. The soil profile does not contain any soft layer and the layers are assumed to be linearly elastic, isotropic, homogeneous and perfectly bonded at the interfaces. Two-dimensional (in-plane) formulation is considered and the analysis is performed on both k- and o-planes through time and spatial Fourier transforms of the field equations and boundary conditions. (Abstract shortened with permission of author.)
6
Jones, Piet. "Structure learning of gene interaction networks." Thesis, Stellenbosch : Stellenbosch University, 2014. http://hdl.handle.net/10019.1/86650.
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Thesis (MSc)--Stellenbosch University, 2014.<br>ENGLISH ABSTRACT: There is an ever increasing wealth of information that is being generated regarding
biological systems, in particular information on the interactions and
dependencies of genes and their regulatory process. It is thus important to be
able to attach functional understanding to this wealth of information. Mathematics
can potentially provide the tools needed to generate the necessary
abstractions to model the complex system of gene interaction.
Here the problem of uncovering gene interactions is cast in several contexts,
namely uncovering gene interaction patterns using statistical dependence, cooccurrence
as well as feature enrichment. Several techniques have been proposed
in the past to solve these, with various levels of success. Techniques
have ranged from supervised learning, clustering analysis, boolean networks
to dynamical Bayesian models and complex system of di erential equations.
These models attempt to navigate a high dimensional space with challenging
degrees of freedom.
In this work a number of approaches are applied to hypothesize a gene
interaction network structure. Three di erent models are applied to real biological
data to generate hypotheses on putative biological interactions. A
cluster-based analysis combined with a feature enrichment detection is initially
applied to a Vitis vinifera dataset, in a targetted analysis. This model
bridges a disjointed set of putatively co-expressed genes based on signi cantly
associated features, or experimental conditions. We then apply a cross-cluster
Markov Blanket based model, on a Saccharomyces cerevisiae dataset. Here
the disjointed clusters are bridged by estimating statistical dependence relationship
across clusters, in an un-targetted approach. The nal model applied
to the same Saccharomyces cerevisiae dataset is a non-parametric Bayesian method that detects probeset co-occurrence given a local background and inferring
gene interaction based on the topological network structure resulting
from gene co-occurance. In each case we gather evidence to support the biological
relevance of these hypothesized interactions by investigating their relation
to currently established biological knowledge.
The various methods applied here appear to capture di erent aspects of
gene interaction, in the datasets we applied them to. The targetted approach
appears to putatively infer gene interactions based on functional similarities.
The cross-cluster-analysis-based methods, appear to capture interactions
within pathways. The probabilistic-co-occurrence-based method appears to
generate modules of functionally related genes that are connected to potentially
explain the underlying experimental dynamics.<br>AFRIKAANSE OPSOMMING: Daar is 'n toenemende rykdom van inligting wat gegenereer word met betrekking
tot biologiese stelsels, veral inligting oor die interaksies en afhanklikheidsverhoudinge
van gene asook hul regulatoriese prosesse. Dit is dus belangrik om
in staat te wees om funksionele begrip te kan heg aan hierdie rykdom van inligting.
Wiskunde kan moontlik die gereedskap verskaf en die nodige abstraksies
bied om die komplekse sisteem van gene interaksies te modelleer.
Hier is die probleem met die beraming van die interaksies tussen gene
benader uit verskeie kontekste uit, soos die ontdekking van patrone in gene
interaksie met behulp van statistiese afhanklikheid , mede-voorkoms asook
funksie verryking. Verskeie tegnieke is in die verlede voorgestel om hierdie
probleem te benader, met verskillende vlakke van sukses. Tegnieke het gewissel
van toesig leer , die groepering analise, boolean netwerke, dinamiese Bayesian
modelle en 'n komplekse stelsel van di erensiaalvergelykings. Hierdie modelle
poog om 'n hoë dimensionele ruimte te navigeer met uitdagende grade van
vryheid.
In hierdie werk word 'n aantal benaderings toegepas om 'n genetiese interaksie
netwerk struktuur voor te stel. Drie verskillende modelle word toegepas
op werklike biologiese data met die doel om hipoteses oor vermeende biologiese
interaksies te genereer. 'n Geteikende groeperings gebaseerde analise gekombineer
met die opsporing van verrykte kenmerke is aanvanklik toegepas op 'n
Vitis vinifera datastel. Hierdie model verbind disjunkte groepe van vermeende
mede-uitgedrukte gene wat gebaseer is op beduidende verrykte kenmerke, hier
eksperimentele toestande . Ons pas dan 'n tussen groepering Markov Kombers
model toe, op 'n Saccharomyces cerevisiae datastel. Hier is die disjunkte groeperings
ge-oorbrug deur die beraming van statistiese afhanklikheid verhoudings tussen die elemente in die afsondelike groeperings. Die nale model was ons
toepas op dieselfde Saccharomyces cerevisiae datastel is 'n nie- parametriese
Bayes metode wat probe stelle van mede-voorkommende gene ontdek, gegee 'n
plaaslike agtergrond. Die gene interaksie is beraam op grond van die topologie
van die netwerk struktuur veroorsaak deur die gesamentlike voorkoms gene.
In elk van die voorgenome gevalle word ons hipotese vermoedelik ondersteun
deur die beraamde gene interaksies in terme van huidige biologiese kennis na
te vors.
Die verskillende metodes wat hier toegepas is, modelleer verskillende aspekte
van die interaksies tussen gene met betrekking tot die datastelle wat
ons ondersoek het. In die geteikende benadering blyk dit asof ons vermeemde
interaksies beraam gebaseer op die ooreenkoms van biologiese funksies. Waar
die a eide gene interaksies moontlik gebaseer kan wees op funksionele ooreenkomste
tussen die verskeie gene. In die analise gebaseer op die tussen
modelering van gene groepe, blyk dit asof die verhouding van gene in bekende
biologiese substelsels gemodelleer word. Dit blyk of die model gebaseer op die
gesamentlike voorkoms van gene die verband tussen groepe van funksionele
verbonde gene modelleer om die onderliggende dinamiese eienskappe van die
experiment te verduidelik.
7
Chin, David 1982. "Wall shear patterns of a 50% asymmetric stenosis model using photochromic molecular flow visualization." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111613.
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Photochromic Molecular Flow Visualization is an in vitro, experimental technique that uses high speed image acquisition combined with an ultraviolet laser to capture instantaneous flow profiles. It is particularly adept at measuring near wall velocities which are necessary for accurate wall shear rate measurements. This thesis describes the implementation and validation of the technique at McGill. The system was used to investigate the wall shear rate patterns in an idealized 50% asymmetric stenosis model under steady flow for Reynolds numbers 206, 99 and 50. A large recirculation zone with flow reattachment was seen downstream of the stenosis with maximum shear values occurring slightly upstream of peak stenosis for Reynolds number 206. This information is vital to ongoing dynamic cell culture experiments aimed at understanding the progression of atherosclerosis.
8
Magal, Rithvik. "Development and validation of a mathematical model for a monotube automotive damper." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2021. http://amslaurea.unibo.it/22951/.
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Automotive dampers involve complex flow physics that cannot be fully described by analytical models derived from first principles. Therefore, the development of a mathematical model based on semi-empirical laws that accurately describe the influence of each of the many design features would greatly help the design and optimization of automotive dampers. This thesis aims to develop a computationally efficient mathematical model capable to predicting damper performance with reasonable accuracy.
Lumped parameter mathematical models were developed and implemented using the MATLAB and Simulink environments. In order to solve for the structural dynamics of the shim stack, a force method based analytical model was developed. In order to solve for the internal flow field, fluid structure interaction simulations were necessitated due to the inherent coupling of fluid and structural dynamics.
Fluid-Structure Interaction (FSI) simulations were attempted using an open source setup consisting of OpenFOAM and CalculiX coupled by the preCICE coupling library. Coupled simulations on a trial simplified geometry produced physically consistent results. FSI simulations could not be performed on the real geometry due to lack of time and computational resources. The discharge coefficients were modelled as a linear function on the basis of CFD simulations perfomed on outputs from the force method model.
In order to validate the MATLAB mathematical model, experiments were carried out on a test automotive damper on a suspension dynamometer. The model showed good agreement in with experimental data at low bleed valve openings. The model accuracy was observed decrease for larger bleed valve openings due to unavailability of accurate model coefficients.
9
Romanel, Celso. "A global-local approach for dynamic soil-structure interaction analysis of deeply embedded structures in a layered medium." Diss., The University of Arizona, 1989. http://hdl.handle.net/10150/184762.
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The most popular method for dynamic soil-structure interaction analysis is the finite element method. The versatility in problems involving different materials and complex geometries is its main advantage, yet the FEM can not simulate unbounded domains completely. Several schemes have been proposed to overcome this shortcoming, such as the use of either imperfect or perfect transmitting boundaries, infinite elements and hybrid techniques. However, most of them were derived on the assumption that the soil mass can be represented as a homogeneous material despite the fact that stratified soil deposits are a common occurrence in nature. A hybrid method is proposed in this research for soil-structure interaction analysis in the frequency domain involving a multilayered linear elastic half-space. The near field region (structure and a portion of soil surrounding it) is modeled by finite elements while the far field formulation is obtained through the classical wave propagation theory based on the assumption that the actual scattered wave fields can be represented by a set of line sources. Traction reciprocity between the two regions is satisfied exactly, while the displacement continuity across the common interface is enforced in a least-squares sense. The two-dimensional system is excited by harmonic body waves (P and SV) propagating with oblique incidence. The structure can be considered either on the surface or deeply embedded in the multilayered half-space. Analytic solutions for the far field domain is obtained through the combined response of four simple problems that take into account the overall effects of the incident, reflected and scattered wave fields. The delta matrix technique is employed in order to eliminate the loss of precision problem associated with the Thomson-Haskell matrix method in its original form. Special numerical schemes are used to transform the solution from the κ- into the ω-plane due to the presence of poles on the path of integration. The few numerical examples studied in this research validate the proposed hybrid technique, but the relatively high computational cost required for evaluation of the Green's functions is still a serious drawback. Some suggestions are made to minimize the problem as well as to extend this technique to cases involving material attenuation and forced vibrations.
10
Ruckman, Christopher E. "A regression-based approach for simulating feedfoward active noise control, with application to fluid-structure interaction problems." Diss., This resource online, 1994. http://scholar.lib.vt.edu/theses/available/etd-06062008-170941/.
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Patel, Nayan V. "Simulation of Hydrodynamic Fragmentation from a Fundamental and an Engineering Perspective." Diss., Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/16225.
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Liquid fragmentation phenomenon is explored from both a fundamental (fully resolved) and an engineering (modeled) perspective. The dual objectives compliment each other by providing an avenue to gain further understanding into fundamental processes of atomization as well as to use the newly acquired knowledge to address practical concerns. A compressible five-equation interface model based on a Roe-type scheme for the simulation of material boundaries between immiscible fluids with arbitrary equation of state is developed and validated. The detailed simulation model accounts for surface-tension, viscous, and body-force effects, in addition to acoustic and convective transport. The material interfaces are considered as diffused zones and a mixture model is given for this transition region. The simulation methodology combines a high-resolution discontinuity capturing method with a low-dissipation central scheme resulting in a hybrid approach for the solution of time- and space-accurate interface problems. Several multi-dimensional test cases are considered over a wide range of physical situations involving capillary, viscosity, and gravity effects with simultaneous presence of large viscosity and density ratios. The model is shown to accurately capture interface dynamics as well as to deal with dynamic appearance and disappearance of material boundaries.
Simulation of atomization processes and its interaction with the flow field in practical devices is the secondary objective of this study. Three modeling requirements are identified to perform Large-Eddy Simulation (LES) of spray combustion in engineering devices. In concurrence with these requirements, LES of an experimental liquid-fueled Lean Direct Injection (LDI) combustor is performed using a subgrid mixing and combustion model. This approach has no adjustable parameters and the entire flow-path through the inlet swirl vanes is resolved. The inclusion of the atomization aspects within LES eliminates the need to specify dispersed-phase size-velocity correlations at the inflow boundary. Kelvin-Helmholtz (or aerodynamic) breakup model by Reitz is adopted for the combustor simulation. Two simulations (with and without breakup) are performed and compared with measurements of Cai et al. Time-averaged velocity prediction comparison for both gas- and liquid-phase with available data show reasonable agreement. The major impact of breakup is on the fuel evaporation in the vicinity of the injector. Further downstream, a wide range of drop sizes are recovered by the breakup simulation and produces similar spray quality as in the no-breakup case.
12
Ho, Yanfang. "Group theoretical analysis of in-shell interaction in atoms." Scholarly Commons, 1985. https://scholarlycommons.pacific.edu/uop_etds/487.
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A group theoretic approach to Layzer's 1/2 expansion method is explored. In part this builds on earlier work of Wulfman(2), of Moshinsky et al(l4), and of Sinanoglu, Herrick(lS), and Kellman (16) on second row atoms.
I investigate atoms with electrons in the 3s-3p-3d shell and find:
1. Wulfman's constant of motion accurately predicts configuration mixing for systems with two to eight electrons in the 3s-3p subshell.
2. The same constant of motion accurately predicts configuration mixing for systems with two electrons in the 3s-3p-3d shell.
3. It accurately predicts configuration mixing in systems of high angular momentum L and of high spin angular momentum S containing three electrons in the 3s-3p-3d shell, but gives less accurate results when L and S are both small.
I also show how effective nuclear charges may be calculated by a group theoretical approach. In addition I explore several new methods for expressing electron repulsion operators in terms of operators of the 80(4,2) dynamical group of one - electron atoms.
13
Chin, Victor B. L. "The dynamic response of pile-soil interfaces during pile driving and dynamic testing events." Monash University, Dept. of Civil Engineering, 2003. http://arrow.monash.edu.au/hdl/1959.1/9421.
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Abdolmaleki, Kourosh. "Modelling of wave impact on offshore structures." University of Western Australia. School of Mechanical Engineering, 2007. http://theses.library.uwa.edu.au/adt-WU2008.0055.
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[Truncated abstract] The hydrodynamics of wave impact on offshore structures is not well understood. Wave impacts often involve large deformations of water free-surface. Therefore, a wave impact problem is usually combined with a free-surface problem. The complexity is expanded when the body exposed to a wave impact is allowed to move. The nonlinear interactions between a moving body and fluid is a complicated process that has been a dilemma in the engineering design of offshore and coastal structures for a long time. This thesis used experimental and numerical means to develop further understanding of the wave impact problems as well as to create a numerical tool suitable for simulation of such problems. The study included the consideration of moving boundaries in order to include the coupled interactions of the body and fluid. The thesis is organized into two experimental and numerical parts. There is a lack of benchmarking experimental data for studying fluid-structure interactions with moving boundaries. In the experimental part of this research, novel experiments were, therefore, designed and performed that were useful for validation of the numerical developments. By considering a dynamical system with only one degree of freedom, the complexity of the experiments performed was minimal. The setup included a plate that was attached to the bottom of a flume via a hinge and tethered by two springs from the top one at each side. The experiments modelled fluid-structure interactions in three subsets. The first subset studied a highly nonlinear decay test, which resembled a harsh wave impact (or slam) incident. The second subset included waves overtopping on the vertically restrained plate. In the third subset, the plate was free to oscillate and was excited by the same waves. The wave overtopping the plate resembled the physics of the green water on fixed and moving structures. An analytical solution based on linear potential theory was provided for comparison with experimental results. ... In simulation of the nonlinear decay test, the SPH results captured the frequency variation in plate oscillations, which indicated that the radiation forces (added mass and damping forces) were calculated satisfactorily. In simulation of the nonlinear waves, the waves progressed in the flume similar to the physical experiments and the total energy of the system was conserved with an error of 0.025% of the total initial energy. The wave-plate interactions were successfully modelled by SPH. The simulations included wave run-up and shipping of water for fixed and oscillating plate cases. The effects of the plate oscillations on the flow regime are also discussed in detail. The combination of experimental and numerical investigation provided further understanding of wave impact problems. The novel design of the experiments extended the study to moving boundaries in small scale. The use of SPH eliminated the difficulties of dealing with free-surface problems so that the focus of study could be placed on the impact forces on fixed and moving bodies.
15
Yamamoto, Nobutaka. "Numerical analysis of shallow circular foundations on sands." University of Western Australia. School of Civil and Resource Engineering, 2006. http://theses.library.uwa.edu.au/adt-WU2006.0038.
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This thesis describes a numerical investigation of shallow circular foundations resting on various types of soil, mainly siliceous and calcareous sands. An elasto-plastic constitutive model, namely the MIT-S1 model (Pestana, 1994), which can predict the rate independent behaviour of different types of soils ranging through uncemented sands, silts and clays, is used to simulating the compression, drained triaxial shear and shallow circular foundation responses. It is found that this model provides a reasonable fit to measured behaviour, particularly for highly compressible calcareous sands, because of the superior modelling of the volumetric compression. The features of the MIT-S1 model have been used to investigate the effects of density, stress level (or foundation size), inherent anisotropy and material type on the response of shallow foundations. It was found that the MIT-S1 model is able to distinguish responses on dilatant siliceous and compressible calcareous sands by relatively minor adjustment of the model parameters. Kinematic mechanisms extracted from finite element calculations show different deformation patterns typical for these sands, with a bulb of compressed material and punching shear for calcareous sand, and a classical rupture failure pattern accompanied by surface heave for siliceous sand. Moreover, it was observed that the classical failure pattern transforms gradually to a punching shear failure pattern as the foundation size increases. From this evidence, a dimensional transition between these failure mechanisms can be defined, referred to as the critical size. The critical size is also the limiting foundation size to apply conventional bearing capacity analyses. Alternative approaches are needed, focusing mainly on the soil compressibility, for shallow foundations greater than the critical size. Two approaches, 1-D compression and bearing modulus analyses, have been proposed for those foundation conditions. From the validations, the former is applicable for extremely large foundations, very loose soil conditions and highly compressible calcareous materials, while the latter is suitable for moderate levels of compressibility or foundation size. It is suggested that appropriate assessment of compression features is of great importance for shallow foundation analysis on sand.
16
Bienen, Britta. "Three-dimensional physical and numerical modelling of jack-up structures on sand." University of Western Australia. School of Civil and Resource Engineering, 2007. http://theses.library.uwa.edu.au/adt-WU2007.0208.
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Mobile offshore jack-up drilling rigs are not custom-designed for a particular location but rated for typical operating characteristics, like water depths. They may be deployed at a number of different sites during their design life. Under the current guidelines, the jack-up is required to be assessed for its suitability for each new proposed location, assuming environmental loading conditions due to wind, waves and current corresponding to a 50-year return period storm applicable to the site. Traditionally, these assessments have been performed in two dimensions, simplifying the jack-up to a plane frame and the loading conditions to be in-plane with the rig's 'axis of symmetry'. This thesis introduces a computer program, named SOS_3D, for the fluid-structure-soil interaction analysis of jack-up response in three dimensions. Extensive experimental series have been performed to provide evidence for the generalisation of the foundationsoil interaction model to general six degree-of-freedom loading conditions and its applicability to load paths and stress levels relevant to jack-up spudcans. These experiments included (1) 1g single footing tests, (2) centrifuge single footing tests and (3) centrifuge model jack-up tests. The latter tests highlighted differences in response and mode of failure depending on the loading direction of the jack-up and re-iterated the importance of three-dimensional modelling. The numerical program SOS_3D introduced early in this thesis was shown to represent a useful tool for the prediction of jack-up behaviour under general combined loading in three dimensions. It provided reasonably good, conservative predictions of the experimentally measured jack-up behaviour.
17
Khan, Irfan. "Direct numerical simulation and analysis of saturated deformable porous media." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/34664.
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Existing numerical techniques for modeling saturated deformable porous media are based on
homogenization techniques and thus are incapable of performing micro-mechanical investigations, such as the effect of micro-structure on the deformational characteristics of the media. In this research work, a numerical scheme is developed based on the parallelized hybrid lattice-Boltzmann finite-element method, that is capable of performing micro-mechanical investigations through direct numerical
simulations.
The method has been used to simulate compression of model saturated porous media made of
spheres and cylinders in regular arrangements. Through these simulations it is found that in the limit of small Reynolds number, Capillary number and strain, the deformational behaviour of a real porous media can be recovered through model porous media when the parameters porosity, permeability and bulk compressive modulus are matched between the two media.
This finding motivated research in using model porous geometries to represent more complex
real porous geometries in order to perform investigations of deformation on the latter. An attempt has been made to apply this technique to the complex geometries of ªfeltº, (a fibrous mat used in paper industries). These investigations lead to new understanding on the effect of fiber diameter on the bulk properties of a fibrous media and subsequently on the deformational behaviour of the media. Further the method has been used to investigate the constitutive relationships in deformable porous media.
Particularly the relationship between permeability and porosity during the deformation of the media is investigated. Results show the need of geometry specific investigations.
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Uchaipichat, Anuchit Civil & Environmental Engineering Faculty of Engineering UNSW. "Experimental investigation and constitutive modelling of thermo-hydro-mechanical coupling in unsaturated soils." Awarded by:University of New South Wales. School of Civil and Environmental Engineering, 2005. http://handle.unsw.edu.au/1959.4/22068.
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A thermo-elastic-plastic model for unsaturated soils has been presented based on the effective stress principle considering the thermo-mechanical and suction coupling effects. The thermo-elastic-plastic constitutive equations for stress-strain relations of the solid skeleton and changes in fluid content and entropy for unsaturated soils have been established. A plasticity model is derived from energy considerations. The model derived covers both associative and non-associative flow behaviours and the modified Cam-Clay is considered as a special case. All model coefficients are identified in terms of measurable parameters. To verify the proposed model, an experimental program has been developed. A series of controlled laboratory tests were carried out on a compacted silt sample using a triaxial equipment modified for testing unsaturated soils at elevated temperatures. Imageprocessing technique was used for measuring the volume change of the samples subjected to mechanical, thermal and hydric loading. It is shown that the effective critical state parameters M, ???? and ???? are independent of temperature and matric suction. Nevertheless, the shape of loading collapse (LC) curve was affected by temperature and suction. Furthermore, the temperature change affected the soil water characteristic curve and an increase in temperature caused a decrease in the air entry suction. The simulations from the proposed model are compared with the experimental results. The model calibration was performed to extract the model parameters from the experimental results. Good agreement between the results predicted using the proposed model and the experimental results was obtained in all cases.
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Bastos, Jaci Carlo Schramm Camara. "Analise experimental e numerica de um jato de dispersão gas-solido." [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/267143.
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Previous issue date: 2009<br>Resumo: Apresenta-se nesta pesquisa uma análise experimental e numérica do comportamento da fase dispersa em um jato circular bifásico confinado e uma comparação com jato circular bifásico livre. Nas análises experimentais, uma câmara pentagonal em acrílico foi utilizada como sistema de confinamento para a obtenção de perfis axiais e radiais de velocidade média, flutuação de velocidade (RMS) e intensidade de turbulência. Estes dados foram analisados a fim de desenvolver uma análise completa da região desenvolvida do jato. Três diferentes jatos foram utilizados para a alimentação da fase gás no topo da câmara, mas apenas o jato central foi carregado com partículas entre 60 e 90µm de diâmetro. Os outros dois foram utilizados para proporcionar uma maior interação entre as fases no interior da câmara. A técnica óptica Phase Doppler Anemometry (PDA), foi empregada na medição da velocidade instantânea da fase sólida e do diâmetro das partículas nas diferentes posições axiais a partir do bico do jato. Nove casos de estudo distintos são investigados individualmente e, em seguida, comparados entre si. Estes casos fornecem informações importantes sobre o comportamento e o efeito do confinamento dos jatos sobre o transporte macrocóspico e turbulento das partículas entre o centro e as regiões de contorno do jato. As análises numéricas tratam da modelagem matemática tridimensional, turbulenta e transiente do escoamento no jato bifásico confinado. O modelo trata as fases gás e sólida a partir de uma abordagem Euleriana. O fechamento das equações de transporte foi realizado utilizando o modelo de turbulência de duas equações k-e para a fase gás e modelos de turbulência de zero-equação para a fase sólida, e ainda em alguns casos esta última apenas sofreu efeitos turbulentos advindos da fase contínua. A acurácia das previsões do modelo em um jato de partículas confinadas com as características médias no tempo, assim como os coeficientes da correlação de turbulência foram avaliados. Perfis radiais de velocidade média e fração volumétrica das partículas foram capturados em quarenta e dois níveis, subdivididos em nove casos e comparados aos dados experimentais adquiridos. O diâmetro médio das partículas utilizado nas simulações foi de 75µm e as velocidades iniciais utilizadas variam entre 3 e 11m/s no jato central. O modelo matemático previu um escoamento desenvolvido semelhante ao que foi encontrado experimentalmente.<br>Abstract: It is presented in this research an experimental and numerical analisys of the dispersed phase behavior in a circular confined two-phase jet and a comparison with circular free two-phase jet. In the experimental analysis, a pentagonal plexiglass chamber was used as confined system for the axial and radial profiles investigation of mean velocity, fluctuation velocity known as RMS velocity and turbulence intensity. These data were analyzed in order to develop a complete analysis in the developed region of the jet. Three different nozzles were used to feed the gas phase at the top of the chamber, but just the central nozzle was loaded with particles between 60 and 90µm of diameter. The other two were used to increase the interaction between the phases in the chamber. An optical technique known as Phase Doppler Anemometry was used to measure the instantaneous velocity of the solid phase and particle diameter in different axial positions of the jet nozzle. Nine different cases of study are investigated individually and then compared among each other. These cases provide important information about the jets behavior and the confinement effect on the macrocospic and turbulent transport of particles between the jet center and the jet contour regions. The numerical analysis deals with three-dimensional, turbulent and transient mathematical modeling of a confined two-phase jet flow. The model treats the gas and the solid phases from an Eulerian approach. The closure of the transport equations have been accomplished by using the k-e turbulence model for the gas phase and the zero-equation turbulence model for the solid phase, and in some cases the latter suffered turbulent effects occuring only from the continuos phase. The accuracy of the model predictions in a particle-laden confined jet with the characteristics as well as turbulence correlation coefficients have been evaluated. Radial mean velocity profiles for the solid phase were computed on forty two axial levels, subdivided in nine cases and compared to the obtained experimental data. The mean particle diameter used in the simulations was 75µm and the initial velocities used vary between 3 and 11m/s. The mathematical model predicted a flow development similar to that found experimentally.<br>Doutorado<br>Desenvolvimento de Processos Químicos<br>Mestre em Engenharia Química
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Linde, Florian. "3D modelling of ship resistance in restricted waterways and application to an inland eco-driving prototype." Thesis, Compiègne, 2017. http://www.theses.fr/2017COMP2389/document.
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Les travaux de cette thèse ont pour but de développer un prototype d’éco-pilote, nommé EcoNav, permettant d’optimiser la vitesse d’un bateau afin de réduire sa consommation de carburant. EcoNav est composé de plusieurs modules dont : un modèle hydraulique 2D simulant l’écoulement hydrodynamique (vitesse du courant et hauteur d’eau) le long du trajet du bateau; - un modèle de résistance à l’avancement servant à alimenter un modèle de prédiction de la consommation de carburant; - un algorithme d’optimisation permettant de trouver le profil optimal de vitesse. Afin de pouvoir estimer la consommation de carburant, un modèle numérique de la résistance à l’avancement en milieu confiné a été développé durant la première partie de cette thèse. Ce modèle numérique 3D simule l’écoulement du fluide autour du bateau et permet de calculer les forces agissant sur sa coque. La résolution des équations RANS est couplée avec un algorithme de quasi-Newton afin de trouver la position d’équilibre du bateau et calculer son enfoncement. Cette méthode est validée en comparant les résultats numériques avec des résultats expérimentaux issus d’essais en bassin de traction. L’influence de l’enfoncement sur la résistance à l’avancement et la précision de la méthode est étudiée en comparant les résultats numériques obtenus avec et sans enfoncement. La précision des modèles empiriques de prédiction de la résistance à l’avancement est également comparée à celle du modèle numérique. Enfin, le modèle numérique est utilisé afin de déterminer si le confinement en largeur ou en profondeur ont une influence identique sur l’augmentation de résistance à l’avancement. Les résultats de cette étude permettent d’établir si le confinement de la voie d’eau peut être caractérisé à l’aide d’un paramètre unique (coefficient de blocage par exemple) ou bien deux paramètres permettant de distinguer le confinement latéral et vertical. Dans la seconde partie de cette thèse, les méthodes numériques utilisées pour le modèle d’éco-pilote sont décrites et comparées afin de sélectionner celles qui sont le plus adaptées à chaque module. EcoNav est ensuite utilisé afin de modéliser un cas réel : celui du bateau automoteur Oural navigant sur la Seine entre Chatou et Poses (153 km). La consommation optimisée est comparée à la consommation non optimisée, calculée à partir des vitesses AIS observées sur le tronçon étudié. L’influence de la trajectoire du bateau et de son temps de parcours sur sa consommation sont également étudiés. Les résultats de ces investigations ont montré qu’optimiser la vitesse du bateau permet d’obtenir une réduction de la consommation de carburant de l’ordre de 8 % et qu’optimiser la trajectoire du bateau ainsi que prendre en compte des informations en temps réel (disponibilité des écluses, trafic sur le fleuve) peuvent permettre de réaliser des économies de carburant supplémentaires<br>An eco-driving prototype, named EcoNav, is developed with the aim of optimizing a vessel speed in order to reduce fuel consumption for a given itinerary. EcoNav is organized in several modules : - a 2D hydraulic model simulating the flow conditions (current speed and water depth) along the itinerary; - a ship resistance model calculating the thrust necessary to counteract the hydrodynamic forces ; - a fuel consumption model calculating the fuel consumption corresponding to the thrust input; - a non linear optimization algorithm calculating the optimal speed profile. In order to evaluate the fuel consumption of an inland vessel, a ship resistance numerical model is developed in the first part of this PhD. This 3D numerical model simulates the flow around an inland self-propelled vessel and evaluates the hydrodynamic forces acting on the hull. A RANS solver is coupled with a quasi-Newton approach to find the equilibrium position and calculate ship sinkage. This method is validated by comparing the results of numerical simulations to towing tank tests. The numerical results with and without sinkage are also compared to study the influence of sinkage on ship resistance and on the accuracy of the method. Additionally, some empirical models are investigated and compared with the accuracy of the numerical method. Finally, the numerical model is used to determine if channel with and water depth restriction contribute to the same amount of ship resistance increase for the same level of restriction. The results of that investigation give insight to whether channel restriction can be characterized by a unique parameter (for instance the blockage ratio) or two parameters to distinguish water depth and channel with effects. In the second part of this PhD, the numerical methods used in the speed optimization model are described and validated. The speed optimization model is then used to simulate a real case: the itinerary of the self-propelled ship Oural on river Seine, between Chatou and Poses (153 km). The optimized fuel consumption is compared with the non-optimized fuel consumption, based on AIS speed profile retrieved on this itinerary. The effects of the ship trajectory and travel duration on fuel consumption are also investigated. The results of those investigations showed that optimizing the ship speed lead to an average fuel saving of 8 % and that using an optimal track and including real time information such as lock availability and river traffic can lead to additional fuel savings
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Tello, Guerra Alexis. "Fluid structure interaction by means of reduced order models." Doctoral thesis, Universitat Politècnica de Catalunya, 2020. http://hdl.handle.net/10803/669328.
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The standard Fluid Structure Interaction coupling (velocity--pressure/displacement) is compared against two novel types of coupling, a Two Field coupling (velocity--pressure/displacement--pressure) and a Three Field coupling (velocity--pressure--stress/displacement--pressure--stress) in this way completing our set of, what we call, field to field equations, all stabilized by means of the VMS method using dynamic and orthogonal sub-scales. The solid Two field fluid structure interaction coupling formulation is benchmarked statically and dynamically. POD is applied to all three fluid structure interaction formulations to obtain reduced basis and asses their performance in a reduced space. Usual numerical benchmarks are shown comparing all three formulations. The three field fluid structure interaction coupling proves to provide very accurate results in both FOM and ROM spaces, making it a reliable formulation. Field to field pairing appears to be beneficial providing more accurate results in all cases shown.
A reduced order model designed by means of a variational multi-scale method stabilized formulation has been applied successfully to fluid structure interaction problems in a strongly coupled partitioned solution scheme. Details of the formulation and the implementation both for the interaction problem and for the reduced models, for both the off-line and on-line phases, are shown. Results are obtained for cases in which both domains are reduced at the same time. Numerical results are presented for a semi-stationary and a fully transient case.<br>El acople estandar para casos de Interacción Fluido Estructura (Velocidad-Presión/Desplazamiento) se compara contra dos nuevas formas de acople, el primero de Dos Campos (Velocidad-Presión/Desplazamiento-Presión) y el segundo de Tres Campos (Velocidad-Presión-Esfuerzo/Desplazamiento-Presión-Esfuerzo) de esta forma completando lo que se ha llamado acoplamiento de Campo a Campo, todo estabilizado por medio del método VMS usando sub-escalas dínamicas y ortogonales. Se hacen comprobaciones estáticas y dínamicas para las dos nuevas formulaciones de sólidos (Dos y Tres campos). Se utiliza POD para obtener una base reducida y verificar el comportamiento de dichas formulaciones en el espacio reducido. La formulacion de Tres Campos resulta ser la mas precisa produciendo los resultados mas exactos tanto para los espacios FOM y ROM. La formulacion de Campo a Campo resulta ser beneficiosa al producir los resultados mas exactos en todas las pruebas realizadas.
Un modelo estabilizado de orden reducido por medio del método de VMS ha sido aplicado satisfactoriamente a problemas de Interacción Fluido-Estructura en un modelos particionado de acople fuerte. Se muestran detalles de la formulación y su implementación tanto para casos de Interacción como para Problemas Reducidos para las fases de cálculo de base y ejecución del modelo. Se han obtenido resultados para problemas de Interacción en el cual se reducen ambos dominios al mismo tiempo. Se presentan resultados numéricos para ejemplos semi-transitorios y totalmente dinámicos.
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Surulescu, Christina. "Modeling aspects and mathematical analysis of some fluid-elastic structure interaction problems." [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972492321.
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Nave, Jr Gary Kirk. "Nonlinear Models and Geometric Structure of Fluid Forcing on Moving Bodies." Diss., Virginia Tech, 2018. http://hdl.handle.net/10919/84945.
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This dissertation presents useful nonlinear models for fluid forcing on a moving body in two distinct contexts, and methods for analyzing the geometric structure within those and other mathematical models. This manuscript style dissertation presents three works within the theme of understanding fluid forcing and geometric structure.
When a bluff body is free to move in the presence of an incoming bluff body wake, the average forcing on the body is dependent on its position relative to the upstream bluff body. This position-dependent forcing can be conceptualized as a stiffness, much like a spring. This work presents an updated model for the quasi-steady fluid forcing of a wake and extends the notion of wake stiffness to consider a nonlinear spring. These results are compared with kinematic experimental results to provide an example of the application of this framework.
Fluid force models also play a role in understanding the behavior of passive aerodynamic gliders, such as gliding animals or plant material. The forces a glider experiences depend on the angle that its body makes with respect to its direction of motion. Modeling the glider as capable of pitch control, this work considers a glider with a fixed angle with respect to the ground. Within this model, all trajectories in velocity space collapse to a 1-dimensional invariant manifold known as the terminal velocity manifold. This work presents methods to identify the terminal velocity manifold, investigates its properties, and extends it to a 2-dimensional invariant manifold in a 3-dimensional space.
Finally, in the search for manifolds such as the terminal velocity manifold, this dissertation introduces a new diagnostic for identifying the low dimensional geometric structure of models. The trajectory divergence rate uses instantaneous vector field information to identify regions of large normal stretching and strong normal convergence between nearby invariant manifolds. This work lays out the mathematical basis of the trajectory divergence rate and shows its application to approximate a variety of structures including slow manifolds and Lagrangian coherent structures.
This dissertation applies nonlinear theoretical and numerical techniques to analyze models of fluid forcing and their geometric structure. The tools developed in this dissertation lay the groundwork for future research in the fields of flow-induced vibration, plant and animal biomechanics, and dynamical systems.<br>Ph. D.
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Scroggs, Richard A. "Validation of computational fluid-structure interaction models by comparison with collapsible tube experiments." Thesis, University of Sheffield, 2002. http://etheses.whiterose.ac.uk/14835/.
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The objective of this thesis was to assess the validity of the fluid-structure interaction (FSI) facilities in LS-DYNA for the analysis of highly deformable structures interacting with flowing viscous fluids. The collapsible tube experiment was chosen as a validation tool for FSI since its three-dimensional computational modelling would have been impossible if the viscous internal fluid flow were not considered. An explicit three-dimensional finite element model of a collapsible-tube was constructed and solved using LS-DYNA. The fully coupled model included internal fluid flow; external, inlet and outlet pressures; tube wall tension; pre-stressing; and contact. The finite element boundary conditions were taken as the recorded values of flow rate and pressure from a standard collapsible-tube experiment for both steady and unsteady flows. The predicted tube geometry in the steady LS-DYNA model showed good agreement with the experiment for operating points in the highly compliant region of the pressure-flow characteristic curve. The comparative position of the pinch at the outlet end differed by only 5.6% of the outlet diameter in the worst case. This analysis represents an advance on other published work in that previously no comparison with experiments have been drawn for FSI models involving high Reynolds number flowing viscous fluids interacting with highly deformable three dimensional structures. This analysis successfully made that comparison and the experimental and computational results have combined to form a more detailed picture of the collapsible-tube phenomenon by including detailed stress results of the tube walls and views of the internal fluid flow. The collapsible tube model exhibited uncertainty errors due to the use of a coarser than desirable mesh and a reduced fluid speed of sound. Although both these approximations caused significant error in the model both were necessary in order to achieve acceptable solution times. Because of these errors a thorough quantitative validation could not be achieved although LS-DYNA has been proven to be qualitatively accurate. Increases in computing speed are required before thorough quantitative validation of FSI can be achieved by comparison with the collapsible tube experiments.
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Siddorn, Philip David. "Efficient numerical modelling of wave-structure interaction." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:de36bd2f-cd23-4f11-b67f-9d8cd48ecd3c.
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Offshore structures are required to survive in extreme wave environments. Historically, the design of these offshore structures and vessels has relied on wave-tank experiments and linear theory. Today, with advances in computing power, it is becoming feasible to supplement these methods of analysis with fully nonlinear numerical simulation. This thesis is concerned with the development of an efficient method to perform this numerical modelling, in the context of potential flow theory. The interaction of a steep ocean wave with a floating body involves a moving free surface and a wide range of length scales. Attempts to reduce the size of the simulation domain cause problems with wave reflection from the domain edge and with the accurate creation of incident waves. A method of controlling the wave field around a structure is presented. The ability to effectively damp an outgoing wave in a very short distance is demonstrated. Steep incident waves are generated without the requirement for the wave to evolve over a large time or distance before interaction with the body. This enables a general wave-structure interaction problem to be modelled in a small tank, and behave as if it were surrounded by a large expanse of water. The suitability of the boundary element method for performing this modelling is analysed. Potential improvements are presented with respect to accuracy, robustness, and computational complexity. Evidence of third order diffraction is found for an FPSO model.
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Chiang, Chen-Yu. "Transport in biological systems. Monolithic method for fluid-structure interaction." Thesis, Sorbonne université, 2019. http://www.theses.fr/2019SORUS477.
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Le travail de cette thèse a pour objectif de développer un solveur dédié aux problèmes d'interaction fluide-structure (IFS), en particulier ceux rencontré en biologie, tels que la dynamique d'un écoulement sanguin à travers des tronçons veineux munis de valves. La circulation du sang est étudiée à l'aide de modèles pertinents sur les plans anatomique et physique. Le premier aspect des problèmes d'IFS concerne la gestion de la stabilité. Une formulation monolithique eulérienne basée sur la méthode des caractéristiques assure la stabilité inconditionnelle et introduit une approximation du premier ordre en temps avec deux modèles distincts de matériaux hyper élastiques. Le second aspect est relatif au contact entre deux parties du domaine solide, tel celui apparaissant entre deux valvules au cours de la fermeture de la valve et à l'état fermé sur un surface valvulaire relativement importante. Un algorithme de contact est proposé et validé à l'aide de tests de référence. L'étude computationnelle de l'écoulement sanguin à travers des tronçons veineux munis de valves est mené, une fois le solveur IFS vérifié et validé. Le domaine computationnel bidimensionnel est soit constitué d'une simple unité de base, soit du modèle de circuit veineux en forme d'échelle avec une veine superficielle et une profonde, communicant par une série de veines perforantes. Un maillage tridimensionnel de l'unité de base a été construit. Les simulations dans ce domaine tridimensionnel nécessite le recours au calcul haute performance. La dynamique de l'écoulement sanguin est fortement couplée à la mécanique de la paroi vasculaire. La paroi déformable des veines et artères de gros calibre est composée de trois couches principales (l'intima, la media, et l'adventitia) constituées de matériaux composites ayant une composition spécifique dans chaque couche. Dans ce travail, la rhéologie de la paroi est supposée être représentée par un matériau du type Mooney-Rivlin<br>The present work aims at developing a numerical solver for fluid-structure interaction (FSI) problems, especially those encountered in biology such as blood circulation in valved veins. Blood flow is investigated using anatomically and physically relevant models. The first aspect of FSI problems is related to management of algorithm stability. An Eulerian monolithic formulation based on the characteristic method unconditionally achieves stability and introduce a first order in time approximation with two distinct hyperelastic material models. The second aspect deals with between-solid domain contact such as that between valve leaflets during closure and in the closed state over a finite surface, which avoid vcusp tilting and back flow. A contact algorithm is proposed and validated using benchmarks. Computational study of blood flow in valved veins is investigated, once the solver was verified and validated. The 2D computational domain comprises a single basic unit or the ladder-like model of a deep and superficial veins communicating by a set of perforating veins. A 3D mesh of the basic unit was also built. Three-dimensional computation relies on high performance computing. Blood flow dynamics is strongly coupled to vessel wall mechanics. Deformable vascular walls of large veins and arteries are composed of three main layers (intima, media, and adventitia) that consist of composite material with a composition specific to each layer. In the present work, the wall rheology is assumed to be a Mooney-Rivlin material
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Mitra, Sourav. "Analysis and control of some fluid models with variable density." Thesis, Toulouse 3, 2018. http://www.theses.fr/2018TOU30162/document.
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Dans cette thèse, nous étudions des modèles mathématiques concernant certains problèmes d'écoulement de fluide à densité variable. Le premier chapitre résume l'ensemble de la thèse et se concentre sur les résultats obtenus, la nouveauté et la comparaison avec la littérature existante. Dans le deuxième chapitre, nous étudions la stabilisation locale des équations non homogènes de Navier-Stokes dans un canal 2d autour du flot de Poiseuille. Nous concevons un contrôle feedback de la vitesse qui agit sur l'entrée du domaine de sorte que la vitesse et la densité du fluide soient stabilisées autour du flot de Poiseuille, à condition que la densité initiale soit donnée par une constante additionnée d'une perturbation dont le support se situe loin du bord latéral du canal. Dans le troisième chapitre, nous étudions un système couplant les équations de Navier-Stokes compressibles à une structure élastique située à la frontière du domaine fluide. Nous prouvons l'existence locale de solutions solides pour ce système couplé. Dans le quatrième chapitre, notre objectif est d'étudier la nulle- contrôlabilité d'un problemè d'interaction fluide-structure linéarisé dans un canal bi dimensional. L'écoulement du fluide est ici modélisé par les équations de Navier-Stokes compressibles. En ce qui concerne la structure, nous considérons une poutre de type Euler-Bernoulli amortie située sur une partie du bord. Dans ce chapitre, nous établissons une inégalité d'observabilité pour le problème considéré d'interaction fluid-structure linéarisé qui constitue le premier pas vers la preuve de la nulle contrôlabilité du système<br>In this thesis we study mathematical models concerning some fluid flow problems with variable density. The first chapter is a summary of the entire thesis and focuses on the results obtained, novelty and comparison with the existing literature. In the second chapter we study the local stabilization of the non-homogeneous Navier-Stokes equations in a 2d channel around Poiseuille flow. We design a feedback control of the velocity which acts on the inflow boundary of the domain such that both the fluid velocity and density are stabilized around Poiseuille flow provided the initial density is given by a constant added with a perturbation, such that the perturbation is supported away from the lateral boundary of the channel. In the third chapter we prove the local in time existence of strong solutions for a system coupling the compressible Navier-Stokes equations with an elastic structure located at the boundary of the fluid domain. In the fourth chapter our objective is to study the null controllability of a linearized compressible fluid structure interaction problem in a 2d channel where the structure is elastic and located at the fluid boundary. In this chapter we establish an observability inequality for the linearized fluid structure interaction problem under consideration which is the first step towards the direction of proving the null controllability of the system
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Aletti, Matteo Carlo Maria. "Mathematical modelling and simulations of the hemodynamics in the eye." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066031/document.
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La structure de l’oeil permet d’observer la microcirculation, grâce aux caméras de fond d’oeil. Ces appareils sont bon marché et couramment utilisés dans la pratique clinique, permettant le dépistage de maladies oculaires. La capacité des vaisseaux à adapter leur diamètre (autorégulation) afin de réguler le débit sanguin est importante dans la microcirculation. L’hémodynamique de l’oeil est impactée par la pression à l’intérieur du globe oculaire (IOP), qui est à son tour influencée par le flux sanguin oculaire. Les altérations de l’autorégulation et l’IOP jouent un rôle dans les maladies oculaires. La modélisation mathématique peut aider à interpréter l’interaction entre ces phénomènes et à mieux exploiter les données médicales disponibles. Dans la première partie, nous présentons un modèle simplifié d’interaction fluidestructure qui inclut l’autorégulation, appliqué à un reseau 3D obtenu par imagerie médicale. Les cellules musculaires lisses regulant le diamètre du vaisseau sont modélisés dans la structure. Ensuite, nous utilisons des équations de poroélasticité pour décrire le flux sanguin dans la choroïde, dans un modèle multi-compartiments de l’oeil. Cette approche permet de rendre compte de la transmission de la pulsatilité de la choroïde à la chambre antérieure, où l’IOP est mesurée. Nous présentons des résultats préliminaires sur la choroïde, l’humeur aqueuse et sur la choroïde couplée avec la vitrée. Enfin, nous présentons un modèle d’ordre réduit pour accélérer des simulations multi-physique. Des modèles de haute précision sont utilisés pour les compartiments d’intérêt et une représentation réduite de l’opérateur de Steklov-Poincaré est utilisée pour les autres compartiments<br>The structure of the eye offers a unique opportunity to directly observe the microcirculation, by means, for instance, of fundus camera, which are cheap devices commonly used in the clinical practice. This can facilitate the screening of systemic deseases such as diabetes and hypertension, or eye diseases such as glaucoma. A key phenomenon in the microcirculation is the autoregulation, which is the ability of certain vessels to adapt their diameter to regulate the blood flow rate in response to changes in the systemic pressure or metabolic needs. Impairments in autoregulation are strongly correlated with pathological states. The hemodynamics in the eye is influenced by the intraocular pressure (IOP), the pressure inside the eye globe, which is in turn influenced by the ocular blood flow. The interest in the IOP stems from the fact that it plays a role in several eye-diseases, such as glaucoma. Mathematical modelling can help in interpreting the interplay between these phenomena and better exploit the available data. In the first part of the thesis we present a simplified fluid-structure interaction model that includes autoregulation. A layer of fibers in the vessel wall models the smooth muscle cells that regulate the diameter of the vessel. The model is applied to a 3D image-based network of retinal arterioles. In the second part, we propose a multi-compartments model of the eye. We use the equations of poroelasticity to model the blood flow in the choroid. The model includes other compartments that transmit the pulsatility from the choroid to the anterior chamber, where the measurements of the IOP are actually performed. We present some preliminary results on the choroid, the aqueous humor and on the choroid coupled with the vitreous. Finally, we present a reduced order modelling technique to speed up multiphysics simulations. We use high fidelity models for the compartments of particular interest from the modelling point of view. The other compartments are instead replaced by a reduced representation of the corresponding Steklov-Poincaré operator
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Williams, Paul David. "Nonlinear interactions of fast and slow modes in rotating, stratified fluid flows." Thesis, University of Oxford, 2003. http://ora.ox.ac.uk/objects/uuid:5365c658-ab60-41e9-b07b-0f635909835e.
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This thesis describes a combined model and laboratory investigation of the generation and mutual interactions of fluid waves whose characteristic scales differ by an order of magnitude or more. The principal aims are to study how waves on one scale can generate waves on another, much shorter scale, and to examine the subsequent nonlinear feedback of the short waves on the long waves. The underlying motive is to better understand such interactions in rotating, stratified, planetary fluids such as atmospheres and oceans. The first part of the thesis describes a laboratory investigation using a rotating, two-layer annulus, forced by imposing a shear across the interface between the layers. A method is developed for making measurements of the two-dimensional interface height field which are very highly-resolved both in space and time. The system's linear normal modes fall into two distinct classes: 'slow' waves which are relatively long in wavelength and intrinsic period, and 'fast' waves which are much shorter and more quickly-evolving. Experiments are performed to categorize the flow at a wide range of points in the system's parameter space. At very small background rotation rates, the interface is completely devoid of waves of both types. At higher rates, fast modes only are generated, and are shown to be consistent with the Kelvin-Helmholtz instability mechanism based on a critical Richardson number. At rotation rates which are higher still, baroclinic instability gives rise to the onset of slow modes, with subsequent localized generation of fast modes superimposed in the troughs of the slow waves. In order to examine the generation mechanism of these coexisting fast modes, and to assess the extent of their impact upon the evolution of the slow modes, a quasi-geostrophic numerical model of the laboratory annulus is developed in the second part of the thesis. Fast modes are filtered out of the model by construction, as the phase space trajectory is confined to the slow manifold, but the slow wave dynamics is accurately captured. Model velocity fields are used to diagnose a number of fast wave radiation indicators. In contrast to the case of isolated fast waves, the Richardson number is a poor indicator of the generation of the coexisting fast waves that are observed in the laboratory, and so it is inferred that these are not Kelvin-Helmholtz waves. The best indicator is one associated with the spontaneous emission of inertia-gravity waves, a generalization of geostrophic adjustment radiation. A comparison is carried out between the equilibrated wavenumbers, phase speeds and amplitudes of slow waves in the laboratory (which coexist with fast modes), and slow waves in the model (which exist alone). There are significant differences between these wave properties, but it is shown that these discrepancies can be attributed to uncertainties in fluid properties, and to model approximations apart from the neglect of fast modes. The impact of the fast modes on the slow modes is therefore sufficiently small to evade illumination by this method of inquiry. As a stronger test of the interaction, a stochastic parameterization of the inertia-gravity waves is included in the model. Consistent with the laboratory/model intercomparison, the parameterized fast waves generally have only a small impact upon the slow waves. However, sufficiently close to a transition curve between two different slow modes in the system's parameter space, it is shown that the fast modes can exert a dominant influence. In particular, the fast modes can force spontaneous transitions from one slow mode to another, due to the phenomenon of stochastic resonance. This finding should be of interest to the meteorological and climate modelling communities, because of its potential to affect model reliability.
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Wijns, Christopher P. "Exploring conceptual geodynamic models : numerical method and application to tectonics and fluid flow." University of Western Australia. School of Earth and Geographical Sciences, 2005. http://theses.library.uwa.edu.au/adt-WU2005.0068.
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Geodynamic modelling, via computer simulations, offers an easily controllable method for investigating the behaviour of an Earth system and providing feedback to conceptual models of geological evolution. However, most available computer codes have been developed for engineering or hydrological applications, where strains are small and post-failure deformation is not studied. Such codes cannot simultaneously model large deformation and porous fluid flow. To remedy this situation in the face of tectonic modelling, a numerical approach was developed to incorporate porous fluid flow into an existing high-deformation code called Ellipsis. The resulting software, with these twin capabilities, simulates the evolution of highly deformed tectonic regimes where fluid flow is important, such as in mineral provinces. A realistic description of deformation depends on the accurate characterisation of material properties and the laws governing material behaviour. Aside from the development of appropriate physics, it can be a difficult task to find a set of model parameters, including material properties and initial geometries, that can reproduce some conceptual target. In this context, an interactive system for the rapid exploration of model parameter space, and for the evaluation of all model results, replaces the traditional but time-consuming approach of finding a result via trial and error. The visualisation of all solutions in such a search of parameter space, through simple graphical tools, adds a new degree of understanding to the effects of variations in the parameters, the importance of each parameter in controlling a solution, and the degree of coverage of the parameter space. Two final applications of the software code and interactive parameter search illustrate the power of numerical modelling within the feedback loop to field observations. In the first example, vertical rheological contrasts between the upper and lower crust, most easily related to thermal profiles and mineralogy, exert a greater control over the mode of crustal extension than any other parameters. A weak lower crust promotes large fault spacing with high displacements, often overriding initial close fault spacing, to lead eventually to metamorphic core complex formation. In the second case, specifically tied to the history of compressional orogenies in northern Nevada, exploration of model parameters shows that the natural reactivation of early normal faults in the Proterozoic basement, regardless of basement topography or rheological contrasts, would explain the subsequent elevation and gravitationally-induced thrusting of sedimentary layers over the Carlin gold trend, providing pathways and ponding sites for mineral-bearing fluids.
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Grimes, Randall Young. "A theoretical and experimental analysis of mitral regurgitation and its interactions with pulmonary venous inflow." Diss., Georgia Institute of Technology, 1996. http://hdl.handle.net/1853/17246.
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Huang, Xueying. "In Vivo MRI-based three-dimensional fluid-structure interaction models and mechanical image analysis for human carotid atherosclerotic plaques." Worcester, Mass. : Worcester Polytechnic Institute, 2009. http://www.wpi.edu/Pubs/ETD/Available/etd-050409-100213/.
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Dissertation (Ph.D.)--Worcester Polytechnic Institute.<br>Keywords: atherosclerotic plaque; fluid-structure Interaction models; MRI-based; rupture; plaque vulnerability assessment. Includes bibliographical references (leaves 116-127).
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Dongaonkar, Ranjeet Manohar. "Integration of microvascular, interstitial, and lymphatic function to determine the effect of their interaction on interstitial fluid volume." [College Station, Tex. : Texas A&M University, 2008. http://hdl.handle.net/1969.1/ETD-TAMU-3114.
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Hariharan, Nathan. "High order simulation of unsteady compressible flows over interacting bodies with overset grids." Diss., Georgia Institute of Technology, 1995. http://hdl.handle.net/1853/12960.
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Singh, Reetu. "Development of Three Dimensional Fluid-Structure Interaction Models for the Design of Surface Acoustic Wave Devices: Application to Biosensing and Microfluidic Actuation." Scholar Commons, 2009. http://scholarcommons.usf.edu/etd/3677.
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Surface acoustic wave (SAW) devices find uses in a plethora of applications including
but not limited to chemical, biological sensing, and microfluidic actuation. The primary aim of
this dissertation is to develop a SAW biosensor, capable of simultaneous detection of target
biomarkers in fluid media at concentrations of picogram/ml to nanogram/ml levels and removal
of non-specific proteins from sensor surface using the process of acoustic streaming, for potential
chemical sensing, medical, and clinical diagnostic applications. The focus is on the development
of three dimensional finite element structural and fluid-structure interaction models to study wave
propagation and acoustic actuation of fluids in a SAW biosensor. This work represents a
significant improvement in understanding fluid flow over SAW devices, over the currently
available continuum model of Nyborg. The developed methodology includes use of a novel
substrate, namely, Langasite coupled with various combinations of novel multidirectional
interdigital transducer (IDT) configurations such as orthogonal, focused IDTs as well as sensor
surface modifications, such as micro-cavities. The current approach exploits the capability of the
anisotropic piezoelectric crystal to launch waves of different characteristics in different
directions, which can be put to the multiple uses including but not limited to sensing via
shear
horizontal waves and biofouling elimination via
Rayleigh wave induced acoustic streaming.
Orthogonal IDTs gives rise to constructive interference, thereby enhancing the magnitudes of
device displacements and fluid velocities. The net effect is an increase in device sensitivity and
acoustic streaming intensity. The use of micro-cavities in the delay path provides a synergistic
effect, thereby further enhancing the device sensitivity and streaming intensity. Focused IDTs are
found to enhance the device displacements and fluid velocities, while focusing the device
displacements and fluid motion at the device focal point, thereby enhancing the SAW device
biosensing performance. The work presented in this dissertation has widespread and immediate
use for enhancing sensor sensitivity and analyte discrimination capabilities as well as biofouling
removal in medical diagnostic applications of SAW sensors. This work also has a broad relevance
to the sensing of multiple biomarkers in medical applications as well as other technologies
utilizing these devices such as microfluidic actuation.
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Nasar, Abouzied. "Eulerian and Lagrangian smoothed particle hydrodynamics as models for the interaction of fluids and flexible structures in biomedical flows." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/eulerian-and-lagrangian-smoothed-particle-hydrodynamics-as-models-for-the-interaction-of-fluids-and-flexible-structures-in-biomedical-flows(507cd0db-0116-4258-81f2-8d242e8984fa).html.
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Fluid-structure interaction (FSI), occurrent in many areas of engineering and in the natural world, has been the subject of much research using a wide range of modelling strategies. However, problems with high levels of structural deformation are difficult to resolve and this is particularly the case for biomedical flows. A Lagrangian flow model coupled with a robust model for nonlinear structural mechanics seems a natural candidate since large distortion of the computational geometry is expected. Smoothed particle Hydrodynamics (SPH) has been widely applied for nonlinear interface modelling and this approach is investigated here. Biomedical applications often involve thin flexible structures and a consistent approach for modelling the interaction of fluids with such structures is also required. The Lagrangian weakly compressible SPH method is investigated in its recent delta-SPH form utilising inter-particle density fluxes to improve stability. Particle shifting is also used to maintain particle distributions sufficiently close to uniform to enable stable computation. The use of artificial viscosity is avoided since it introduces unphysical dissipation. First, solid boundary conditions are studied using a channel flow test. Results show that when the particle distribution is allowed to evolve naturally instabilities are observed and deviations are noted from the expected order of accuracy. A parallel development in the SPH group at Manchester has considered SPH in Eulerian form (for different applications). The Eulerian form is applied to the channel flow test resulting in improved accuracy and stability due to the maintenance of a uniform particle distribution. A higher-order accurate boundary model is developed and applied for the Eulerian SPH tests and third-order convergence is achieved. The well documented case of flow past a thin plate is then considered. The immersed boundary method (IBM) is now a natural candidate for the solid boundary. Again, it quickly becomes apparent that the Lagrangian SPH form has limitations in terms of numerical noise arising from anisotropic particle distributions. This corrupts the predicted flow structures for moderate Reynolds numbers (O(102)). Eulerian weakly compressible SPH is applied to the problem with the IBM and is found to give accurate and convergent results without any numerical stability problems (given the time step limitation defined by the Courant condition). Modelling highly flexible structures using the discrete element model is investigated where granular structures are represented as bonded particles. A novel vector-based form (the V-Model) is identified as an attractive approach and developed further for application to solid structures. This is shown to give accurate results for quasi-static and dynamic structural deformation tests. The V-model is applied to the decay of structural vibration in a still fluid modelled using Eulerian SPH with no artificial stabilising techniques. Again, results are in good agreement with predictions of other numerical models. A more demanding case representative of pulsatile flow through a deep leg vein valve is also modelled using the same form of Eulerian SPH. The results are free of numerical noise and complex FSI features are captured such as vortex shedding and non-linear structural deflection. Reasonable agreement is achieved with direct in-vivo observations despite the simplified two-dimensional numerical geometry. A robust, accurate and convergent method has thus been developed, at present for laminar two-dimensional low Reynolds number flows but this may be generalised. In summary a novel robust and convergent FSI model has been established based on Eulerian SPH coupled to the V-Model for large structural deformation. While these developments are in two dimensions the method is readily extendible to three-dimensional, laminar and turbulent flows for a wide range of applications in engineering and the natural world.
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Taylor, Cassandra Jeanne. "Internal Deformation Measurements and Optimization of Synthetic Vocal Fold Models." BYU ScholarsArchive, 2018. https://scholarsarchive.byu.edu/etd/8819.
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Developing lifelike vocal fold models is challenging due to various associatedbiomechanical complexities. Nevertheless, the development and analysis of improved vocal foldmodels is worthwhile since they are valuable tools for gaining insight into human vocal foldvibratory, aerodynamic, and acoustic response characteristics. This thesis seeks to contribute tothe development of computational and physical vocal fold modeling in two ways. First is byintroducing a method of obtaining internal deformation fields within vibrating synthetic vocal foldmodels; second is by presenting an optimization algorithm coupled with a computational vocalfold model to optimize geometry and stiffness of a synthetic vocal fold model to achieve morerealistic vibration patterns.The method for tracking the internal deformation of self-oscillating vocal fold models isbased on MR imaging. Silicone models scaled to four times life-size to lower the flow-inducedvibration frequency were imbedded with fiducial markers in a coronal plane. Candidate markermaterials were tested using static specimens, and two materials, cupric sulfate and glass, werechosen for testing in the vibrating VF models. The vibrating models were imaged using a gatedMRI protocol wherein MRI acquisition was triggered using the subglottal pressure signal. Twodimensionalimage slices at different phases during self-oscillation were captured, and in eachphase the fiducial markers were clearly visible. The process was also demonstrated using a threedimensionalscan at two phases. The benefit of averaging to increase signal-to-noise ratio wasexplored. The results demonstrate the ability to use MRI to acquire quantitative deformation datathat could be used, for example, to validate computational models of flow-induced VF vibrationand quantify deformation fields encountered by cells in bioreactor studies.A low fidelity, two-dimensional, finite element model of VF flow-induced vibration wascoupled with a custom MATLAB-based genetic algorithm optimizer. The objective was to achievea closed quotient within the normal human physiological range. The results showed that changesin geometry and stiffness would lead to a model that exhibited the desired characteristics. Aphysical model based on optimized parameters was then fabricated and the closed quotient wastested. The physical model successfully vibrated with nonzero closed quotient as predicted by thecomputational model.
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Sidiqi, Mahjooba. "The structure and RNA-binding of poly (C) protein 1." University of Western Australia. School of Biomedical, Biomolecular and Chemical Sciences, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0077.
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[Truncated abstract] Regulation of mRNA stability is an important posttranscriptional mechanism involved in the control of gene expression. The rate of mRNA decay can differ greatly from one mRNA to another and may be regulated by RNA-protein interactions. A key determinant of mRNA decay are sequence instability (cis) elements often located in the 3' untranslated region (UTR) of many mRNAs. For example, the AU rich elements (AREs), are such well characterized elements, and most commonly involved in promoting mRNA degradation, and specific binding of proteins to these elements leading to the stabilization of some mRNAs. Other cis-elements have been described for mRNA in which mRNA stability is a critical component of gene regulation. This includes the androgen receptor (AR) UC-rich cis element in its 3'UTR. The AR is a key target for therapeutics in human prostate cancer and thus understanding the mechanism involved in regulating its expression is an important goal. The [alpha]CP1 protein, a KH-domain containing RNA-binding protein has been found to bind this UC-rich region of the AR and is thought to play an important role in regulating AR mRNA expression. [alpha]CP1 protein is a triple KH (hnRNP K homology) domain protein with specificity for Crich tracts of RNA and ssDNA (single stranded DNA). Relatively little is known about the structural interaction of [alpha]CP1 with target RNA cis elements, thus the present study aimed to better understand the nature of interaction between 30 nt 3'UTR UC-rich AR mRNA and [alpha]CP1 protein using various biophysical techniques, in an attempt to determine which [alpha]CP1 domain or combination of domains is involved in RNA-binding. These studies could ultimately provide novel targets for drugs aimed to regulate AR mRNA expression in prostate cancer cells. At the commencement of this study little was known about the structure of the [alpha]CP1- KH domains and their basis for poly (C) binding specificity. ... Additional studies addressed the significance of the four core recognition nucleotides (TCCC) using a series of cytosine to thymine mutants. The findings verified some of the results predicted from structural studies, especially the need for maximum KH binding to a core tetranucleotide recognition sequence. Our mutational studies of the four core bases confirmed the importance of cytosine in positions two and three as no binding was observed, while some binding was observed when the fourth base was mutated. In summary, the work presented in this thesis provides new detailed insight into the molecular interactions between the [alpha]CP1-KH domain and AR mRNA. Furthermore, these studies shed light on the nature of protein/mRNA interactions in general, as well as the specific complex that forms on AR mRNA. These studies have provided new understanding into the mode of [alpha]CP1 binding at a target oligonucleotide binding site and, provide a foundation for future studies to define structure of multiprotein/oligonucleotide complexes involved in AR mRNA gene regulation. Understanding the detailed interaction between the AR mRNA and [alpha]CP1 could provide possible targets for drug development at reducing AR expression in prostate cancer cells by interfering with the interaction of [alpha]CP1 and AR-mRNA.
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Khatib, Nader El. "Modélisation mathématique de l’athérosclérose." Thesis, Lyon 1, 2009. http://www.theses.fr/2009LYO10067/document.
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L'athérosclérose est une maladie inflammatoire qui commence quand les lipoprotéines de faible densité (LDL) entrent dans l'intima du vaisseau sanguin où elles sont oxydées (ox-LDL). Le ox-LDL est considéré comme un agent dangereux par le système immunitaire provoquant ainsi une réponse immunitaire. Cette réponse immunitaire déclenche le recrutement des monocytes dans l'intima où elles se transforment en macrophages et ensuite en cellules spumeuses. Ce dernier amplifie la production des cytokines inflammatoires et davantage de recrutement des monocytes. Ce processus auto-amplifié est compensé par la sécrétion de cytokines anti-inflammatoires (anti-inflammation biochimique) et la migration des cellules musculaires lisses pour former une chape fibreuse qui couvre le noyau lipidique. Cette chape fibreuse avec le noyau lipidique s'appellent la plaque d'athérosclérose. Celle-ci change la géométrie du vaisseau sanguin en le rétrécissant et interagit avec du flux sanguin. Cette interaction peut avoir des conséquences dangereuses liées à la rupture de plaque ou à la formation du caillot de sang. La thèse est consacrée à la modélisation mathématique de ces phénomènes. Elle est composée de deux parties : Nous développons des modèles mathématiques basés sur des équations de réaction diffusion afin de décrire le processus inflammatoire. Le premier modèle est unidimensionnel. Il nous permet d'expliquer comment le développement de l'athérosclérose dépend de la concentration en cholestérol (ox-LDL). Si cette concentration dans l'intima est basse, alors la maladie ne se développera pas. Les concentrations intermédiaires de ox-LDL peuvent mener au développement de la maladie dans certaines conditions. Nous montrons que l'inflammation se propage en front d'ondes de réaction-diffusion. Les concentrations élevées de ox-LDL engendre le développement de la maladie. Même une petite perturbation du cas non inflammatoire mène à une propagation d'ondes qui correspond à l'inflammation. Ensuite nous étudions un modèle bidimensionnel qui représente un système d'équations type réaction-diffusion sur une bande. La deuxième dimension correspond à la section transversale de l'intima et une condition aux limites non-linéaire décrit le recrutement des monocytes. Cette condition aux limites est une fonction des concentrations des cytokines. Nous démontrons l'existence des fronts de propagation d'onde et confirmons les résultats précédents qui montrent que l'athérosclérose se développe en tant qu'onde de réaction-diffusion. Les résultats théoriques des deux modèles sont confirmés par des simulations numériques qui montrent que le cas bidimensionnel converge vers le cas unidimensionnel quand l'épaisseur de l'intima tend vers zéro. Une fois la plaque se forme, elle interagit avec le flux sanguin engendrant de différentes conséquences mécaniques et biochimiques. Nous développons un modèle d'interaction fluide-structure. La plaque d'athérome composée d'un dépôt lipidique couvert par une chape fibreuse, les deux étant modélisés en tant que matériaux hyper-élastiques. Le sang est considéré comme un fluide non-Newtonien avec une viscosité variable modélisée selon la loi de Carreau. Les paramètres utilisés dans nos simulations sont tirés de données expérimentales mentionnées dans la littérature. Nous étudions les effets non-Newtoniens sur les recirculations du sang en aval de la plaque d'athérome et aussi sur les contraintes sur celle-ci. Les simulations montrent que le modèle Newtonien surestime les recirculations de manière significative par rapport au modèle non-Newtonien. Elles montrent aussi que le modèle Newtonien sous-estime légèrement les contraintes sur la plaque pour des taux de cisaillement usuels, mais cette sous-estimation devient importante pour des taux de cisaillement bas<br>Atherosclerosis is an inflammatory disease which starts when low density lipoproteins (LDL) enter the intima of blood vessel where they are oxidized (ox-LDL). The ox-LDL is considered as a dangerous agent by the immune system provoking an anti-inflammatory response. This immune response triggers the recruitment of monocytes into the intima where they differentiate into macrophages and foam cells. The latter amplifies the production of inflammatory cytokines and further recruitment of monocytes. This auto-amplified process is compensated by the secretion of anti-inflammatory cytokines (biochemical anti-inflammation) and triggers the migration of smooth muscle cells to form a fibrous cap that covers the lipid core. These fibrous caps with the lipid core are called atherosclerosis plaque. It changes the geometry of the blood vessel by narrowing it and interacts with the blood flow. This interaction may have dangerous consequences related to the plaque rupture or to the formation of blood clot. The PhD thesis is devoted to mathematical modelling of these phenomena. It consists of two major parts : We develop mathematical models based on reaction-diffusion equations in order to describe the inflammatory process. The first model is one-dimensional. It allows us to explain how the development of atherosclerosis depends on the cholesterol (ox-LDL) concentration. If its concentration in the intima is low, then the disease will not develop. Intermediate ox-LDL concentrations can lead to the disease development under certain conditions. We show that the inflammation propagates as a reaction-diffusion wave. High ox-LDL concentrations will necessary result in the disease development. Even a small perturbation of the non inflammatory case leads to a travelling wave propagation which corresponds to a chronic inflammatory response. We then study a two-dimensional model which represents a reaction-diffusion system in a strip. The second dimension corresponds to the cross-section of the intima, nonlinear boundary conditions describe the recruitment of monocytes as a function of the cytokines concentration. We prove the existence of travelling waves and confirm our previous results which show that atherosclerosis develops as a reaction-diffusion wave. The theoretical results of the two models are confirmed by numerical simulations that show that the two-dimensional model converge to the one-dimensional one if the thickness of the intima tends to zero. When the plaque is formed, it interacts with blood flow resulting in various mechanical and bio-chemical effects. We develop a fluid-structure interaction model. The atheroma plaque is composed of a lipid pool and a fibrous cap and both are modeled as hyper elastic materials. The blood is supposed to be a non-Newtonian fluid with a variable viscosity modeled by the Carreau law. The parameters used in our simulations are taken from experimental data found in literature. We investigate the non-Newtonian effects on the re circulations downstream of the atheroma plaque and on the stress over the plaque. The simulations show that the Newtonian model significantly overestimates the re circulations in comparison with the non-Newtonian model. They also show that the Newtonian model slightly underestimates the stress over the plaque for usual shear rates, but this underestimation can become significant for low shear rates
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Lacis, Ugis. "Models of porous, elastic and rigid materials in moving fluids." Doctoral thesis, KTH, Stabilitet, Transition, Kontroll, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-195679.
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Tails, fins, scales, and surface coatings are used by organisms for various tasks, including locomotion. Since millions of years of evolution have passed, we expect that the design of surface structures is optimal for the tasks of the organism. These structures serve as an inspiration in this thesis to identify new mechanisms for flow control. There are two general categories of fluid-structure-interaction mechanisms. The first is active interaction, where an organism actively moves parts of the body or its entire body in order to modify the surrounding flow field (e.g., birds flapping their wings). The second is passive interaction, where appendages or surface textures are not actively controlled by the organism and hence no energy is spent (e.g., feathers passively moving in the surrounding flow). Our aim is to find new passive mechanisms that interact with surrounding fluids in favourable ways; for example, to increase lift and to decrease drag. In the first part of this work, we investigate a simple model of an appendage (splitter plate) behind a bluff body (circular cylinder or sphere). If the plate is sufficiently short and there is a recirculation region behind the body, the straight position of the appendage becomes unstable, similar to how a straight vertical position of an inverted pendulum is unstable under gravity. We explain and characterize this instability using computations, experiments and a reduced-order model. The consequences of this instability are reorientation (turn) of the body and passive dispersion (drift with respect to the directionof the gravity). The observed mechanism could serve as a means to enhance locomotion and dispersion for various motile animals and non-motile seeds. In the second part of this thesis, we look into effective models of porous and poroelastic materials. We use the method of homogenization via multi-scale expansion to model a poroelastic medium with a continuum field. In particular, we derive boundary conditions for the velocity and the pressure at the interface between the free fluid and the porous or poroelastic material. The results obtained using the derived boundary conditions are then validated with respect to direct numerical simulations (DNS) in both two-dimensional and three-dimensional settings. The continuum model – coupled with the necessary boundary conditions – gives accurate predictions for both the flow field and the displacement field when compared to DNS.<br>Många djur använder sig av fjäll, päls, hår eller fjädrar för att öka sin förmåga att förflytta sig i luft eller vatten. Eftersom djuren har genomgått miljontals år av evolution, kan man förvänta sig att ytstrukturernas form är optimala för organismens uppgifter. Dessa strukturer tjänar som inspiration i denna avhandling för att identifiera nya mekanismer för manipulering av strömning. Samverkan mellan fluider och strukturer (så kallad fluid-struktur-interaktion) kan delas upp i två kategorier. Den första typen av samverkan är aktiv, vilket innebär att en organism aktivt rör hela eller delar av sin kropp för att manipulera det omgivande strömningsfältet (till exempel fåglar som flaxar sina vingar). Den andra typen är passiv samverkan, där organismer har utväxter (svansar, fjärdar, etc.) eller ytbeläggningar som de inte aktivt har kontroll över och som således inte förbrukar någon energi. Ett exempel är fjädrar som passivt rör sig i det omgivande flödet. Vårt mål är att hitta nya passiva mekanismer som växelverkar med den omgivande fluiden på ett fördelaktigt sätt, exempelvis genom att öka lyftkraften eller minska luftmotståndet. I den första delen av detta arbete undersöker vi en enkel modell för en utväxt (i form av en platta) bakom en cirkulär cylinder eller sfär. Om plattan är tillräckligt kort och om det finns ett vak bakom kroppen kommer det upprätta läget av plattan att vara instabilt. Denna instabilitet är i princip samma som uppstår då man försöker balansera en penna på fingret. Vi förklarar den bakomliggande mekanismen av denna instabilitet genom numeriska beräkningar, experiment och en enkel modell med tre frihetsgrader. Konsekvenserna av denna instabilitet är en omorientering (rotation) av kroppen och en sidledsförflyttning av kroppen i förhållande till tyngdkraftens riktning. Denna mekanism kan användas djur och frön för att öka deras förmåga att förflytta eller sprida sig i vatten eller luft. I den andra delen av avhandlingen studerar vi modeller av porösa och elastiska material. Vi använder en mångskalig metod för att modellera det poroelastiska materialet som ett kontinuum. Vi härleder randvillkor för både hastighetsfältet och trycket på gränssnittet mellan den fria fluiden och det poroelastiska materialet. Resultaten som erhållits med de härledda randvillkoren valideras sedan genom direkta numeriska simuleringar (DNS) för både två- och tredimensionella fall. Kontinuumsmodellen av materialet kopplad genom randvillkoren till den fria strömmande fluiden predikterar strömnings- och förskjutningsfält noggrant i jämförelse med DNS.
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Neumann, Sönke [Verfasser], and Norbert [Akademischer Betreuer] Hoffmann. "Fluid-structure interaction of flexible lifting bodies with multi-body dynamics of order-reduced models and the actuator-line method / Sönke Neumann. Betreuer: Norbert Hoffmann." Hamburg : Universitätsbibliothek der Technischen Universität Hamburg-Harburg, 2016. http://d-nb.info/1091059357/34.
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Volpi, Silvia. "High-fidelity multidisciplinary design optimization of a 3D composite material hydrofoil." Diss., University of Iowa, 2018. https://ir.uiowa.edu/etd/6325.
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Multidisciplinary design optimization (MDO) refers to the process of designing systems characterized by the interaction of multiple interconnected disciplines. High-fidelity MDO usually requires large computational resources due to the computational cost of achieving multidisciplinary consistent solutions by coupling high-fidelity physics-based solvers. Gradient-based minimization algorithms are generally applied to find local minima, due to their efficiency in solving problems with a large number of design variables. This represents a limitation to performing global MDO and integrating black-box type analysis tools, usually not providing gradient information. The latter issues generally inhibit a wide use of MDO in complex industrial applications.
An architecture named multi-criterion adaptive sampling MDO (MCAS-MDO) is presented in the current research for complex simulation-based applications. This research aims at building a global derivative-free optimization tool able to employ high-fidelity/expensive black-box solvers for the analysis of the disciplines. MCAS-MDO is a surrogate-based architecture featuring a variable level of coupling among the disciplines and is driven by a multi-criterion adaptive sampling (MCAS) assessing coupling and sampling uncertainties. MCAS uses the dynamic radial basis function surrogate model to identify the optimal solution and explore the design space through parallel infill of new solutions.
The MCAS-MDO is tested versus a global derivative-free multidisciplinary feasible (MDF) approach, which solves fully-coupled multidisciplinary analyses, for two analytical test problems. Evaluation metrics include number of function evaluations required to achieve the optimal solution and sample distribution. The MCAS-MDO outperforms the MDF showing a faster convergence by clustering refined function evaluations in the optimum region.
The architecture is applied to a steady fluid-structure interaction (FSI) problem, namely the design of a tapered three-dimensional carbon fiber-reinforced plastic hydrofoil for minimum drag. The objective is the design of shape and composite material layout subject to hydrodynamic, structural, and geometrical constraints. Experimental data are available for the original configuration of the hydrofoil and allow validating the FSI analysis, which is performed coupling computational fluid dynamics, solving the Reynolds averaged Navier-Stokes equations, and finite elements, solving the structural equation of elastic motion. Hydrofoil forces, tip displacement, and tip twist are evaluated for several materials providing qualitative agreement with the experiments and confirming the need for the two-way versus one-way coupling approach in case of significantly compliant structures.
The free-form deformation method is applied to generate shape modifications of the hydrofoil geometry. To reduce the global computational expense of the optimization, a design space assessment and dimensionality reduction based on the Karhunen–Loève expansion (KLE) is performed off-line, i.e. without the need for high-fidelity simulations. It provides with a selection of design variables for the problem at hand through basis rotation and re-parametrization. By using the KLE, an efficient design space is identified for the current problem and the number of design variables is reduced by 92%.
A sensitivity analysis is performed prior to the optimization to assess the variability associated with the shape design variables and the composite material design variable, i.e. the fiber orientation. These simulations are used to initialize the surrogate model for the optimization, which is carried out for two models: one in aluminum and one in composite material. The optimized designs are assessed by comparison with the original models through evaluation of the flow field, pressure distribution on the body, and deformation under the hydrodynamic load. The drag of the aluminum and composite material hydrofoils is reduced by 4 and 11%, respectively, increasing the hydrodynamic efficiency by 4 and 7%. The optimized designs are obtained by evaluating approximately 100 designs. The quality of the results indicates that global derivative-free MDO of complex engineering applications using expensive black-box solvers can be achieved at a feasible computational cost by minimizing the design space dimensionality and performing an intelligent sampling to train the surrogate-based optimization.
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Pittard, Matthew Thurlow. "Large Eddy Simulation Based Turbulent Flow-induced Vibration of Fully Developed Pipe Flow." Diss., CLICK HERE for online access, 2003. http://contentdm.lib.byu.edu/ETD/image/etd295.pdf.
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Devkota, Bishnu Hari. "A new Lagrangian model for the dynamics and transport of river and shallow water flows." University of Western Australia. Centre for Water Research, 2005. http://theses.library.uwa.edu.au/adt-WU2005.0108.
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This study presents a new Lagrangian model for predicting dynamics and transport in rivers and shallow water flows. A hydrostatic model is developed for the prediction of rivers and floodplain flow and lateral interactions between them. The model is extended to the Boussinesq weakly non-linear, non-hydrostatic model for the simulation of solitary waves and undular bores. A model for advection-diffusion transport of tracers in open channel flow is also presented. The simulation results are compared against an analytical solution and published laboratory data, field data and theoretical results. It is demonstrated that the Lagrangian moving grid eliminates numerical diffusion and oscillations; the model is dynamically adaptive, providing higher resolution under the wave by compressing the parcels (grid). It also allows flow over dry beds and moving boundaries to be handled efficiently. The hydrostatic model results have shown that the model accurately simulates wave propagation and non-linear steepening until wave breaking. The model is successfully applied to simulate flow and lateral interactions in a compound channel and flood wave movement in a natural river. The non-hydrostatic model has successfully reproduced the general features of solitary waves such as the balance between non-linearity and wave dispersion and non-linear interactions of two solitary waves by phase-shift. Also, the model successfully reproduced undular bores (high frequency short waves) from a long wave and the predicted maximum height of the leading wave agreed very well with the published results. It is shown that the simple second order accurate Lagrangian scheme efficiently simulates dispersive waves without any numerical diffusion. Lagrangian modeling of advection-diffusion transport of Gaussian tracer distributions, top hat tracer distributions and steep fronts (step function) in steady, uniform flow has provided exact results and has shown that the scheme allows the use of a large time step without any numerical diffusion and oscillations, including for the advection of steep fronts. The scheme can handle large Courant numbers (results are presented for Cr = 0 to 20) and the entire range of grid Peclet numbers from zero to infinity. The model is successfully applied to tracer transport due to flow induced by simple waves, solitary waves and undular bores
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Spühler, Jeannette Hiromi. "Patient-Specific Finite Element Modeling of the Blood Flow in the Left Ventricle of a Human Heart." Doctoral thesis, KTH, Beräkningsvetenskap och beräkningsteknik (CST), 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-215277.
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Heart disease is the leading cause of death in the world. Therefore, numerous studies are undertaken to identify indicators which can be applied to discover cardiac dysfunctions at an early age. Among others, the fluid dynamics of the blood flow (hemodymanics) is considered to contain relevant information related to abnormal performance of the heart.This thesis presents a robust framework for numerical simulation of the fluid dynamics of the blood flow in the left ventricle of a human heart and the fluid-structure interaction of the blood and the aortic leaflets.We first describe a patient-specific model for simulating the intraventricular blood flow. The motion of the endocardial wall is extracted from data acquired with medical imaging and we use the incompressible Navier-Stokes equations to model the hemodynamics within the chamber. We set boundary conditions to model the opening and closing of the mitral and aortic valves respectively, and we apply a stabilized Arbitrary Lagrangian-Eulerian (ALE) space-time finite element method to simulate the blood flow. Even though it is difficult to collect in-vivo data for validation, the available data and results from other simulation models indicate that our approach possesses the potential and capability to provide relevant information about the intraventricular blood flow.To further demonstrate the robustness and clinical feasibility of our model, a semi-automatic pathway from 4D cardiac ultrasound imaging to patient-specific simulation of the blood flow in the left ventricle is developed. The outcome is promising and further simulations and analysis of large data sets are planned.In order to enhance our solver by introducing additional features, the fluid solver is extended by embedding different geometrical prototypes of both a native and a mechanical aortic valve in the outflow area of the left ventricle.Both, the contact as well as the fluid-structure interaction, are modeled as a unified continuum problem using conservation laws for mass and momentum. To use this ansatz for simulating the valvular dynamics is unique and has the expedient properties that the whole problem can be described with partial different equations and the same numerical methods for discretization are applicable.All algorithms are implemented in the high performance computing branch of Unicorn, which is part of the open source software framework FEniCS-HPC. The strong advantage of implementing the solvers in an open source software is the accessibility and reproducibility of the results which enhance the prospects of developing a method with clinical relevance.<br><p>QC 20171006</p>
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Rosetti, Guilherme Feitosa. "Desenvolvimento da modelagem de turbulência e interação fluido-estrutura para as vibrações induzidas por vórtices de cilindro rígido." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/3/3135/tde-11072016-085040/.
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Esta tese apresenta o desenvolvimento e aplicação de modelos de turbulência, transição laminar-turbulenta e de interações fluido-estrutura ao escoamento externo em cilindro rígido estacionário e em vibrações induzidas por vórtices. Tais desenvolvimentos foram realizados no código ReFRESCO, baseado em técnicas de dinâmica de fluidos computacional (CFD). Realizou-se um estudo quanto ao desempenho do modelo k- SST em extensa faixa de números de Reynolds, segundo o qual se identificaram as deficiências de modelagem para este escoamento. A modelagem adaptativa das escalas (SAS) e o modelo de transição por correlações locais (LCTM), ambos combinados ao SST, melhoraram a aderência aos resultados experimentais para este escoamento, em uma contribuição original deste trabalho. A aplicação de técnicas de verificação e validação possibilitou a estimação de incertezas e erros para os modelos e números de Reynolds e também de identificada como outra contribuição deste trabalho. A combinação da modelagem em SST, SAS e LCTM com movimentos impostos de realizada para números de Reynolds moderados, diferentes frequências e amplitudes de vibração, algo que poucas publicações abordam em detalhes. Com relação aos movimentos livres, este trabalho traz contribuições com a aplicação dos modelos SST e SAS ao estudo de vibrações induzidas por vórtices em dois graus de liberdade, baixa razão de massa e números de Reynolds moderados, mais altos do que normalmente observados na literatura. Por fim, a investigação da importância relativa de efeitos da turbulência aos casos de movimentos livres e impostos, com relação ao caso de cilindro estacionário, comprovou a conjetura formulada na parte inicial deste trabalho, no que tange à escolha do modelo de turbulência em determinadas aplicações. Tal escolha mostrou-se menos decisiva no caso do cilindro em movimento imposto e ainda menos nos movimentos livres, em comparação ao caso estacionário, uma vez que a resposta em movimentos do corpo filtra grande parte dos efeitos turbulentos de ordem superior. Esta observação mostra-se relevante, uma vez que pode permitir simplificações na modelagem e aplicação de ferramentas de CFD em uma classe importante de projetos de engenharia.<br>This thesis presents the development, implementation and application of turbulence and laminar-turbulent transition models and fuid-structure capabilities to address the vortexshedding and vortex-induced vibrations of a rigid cylinder. These numerical developments have been carried out in the computational fuid dynamics (CFD) code ReFRESCO. In the current work, an investigation of the performance of the turbulence modeling with k- SST in a broad range of Reynolds numbers is carried out identifying its modeling deficiencies for this fow. The implementation and systematic application of the scale adaptive simulations (SAS) and the local correlation transition model (LCTM), both combined with the SST, have improved the agreement with experimental results for the cylinder ow, in a novel contribution of this work. The application of verification and validation technique has allowed the estimation of numerical errors and uncertainties for the diferent models. That is also identified as a contribution of this thesis. The combination of SST modeling with imposed motions is carried out as well as with the SAS and LCTM for moderate Reynolds numbers, diferent vibration frequencies and amplitudes, which is considered novel, as few publications address this issue in extent. Regarding the free-moving cylinder capabilities, the present work brings contributions with the application of SST and SASSST with free-moving cylinder for the study of VIV of two degrees of-freedom, low mass ratio and moderate Reynolds numbers, higher than commonly seen in the literature. Finally, the investigation of the relative importance of turbulence effects on the freemoving cylinder and the imposed-motions case, with respect to the fixed case is carried out. A natural conjecture that has been raised early on this work and proved correct is that, for engineering applications, the choice of turbulence modeling strategy is less decisive when the cylinder is moving with prescribed motion and even less stringent, for free motions as the body response filters most of the higher order turbulence effects. That is a relevant observation as it might allow modeling simplifications and the application of CFD tools to a range of engineering problems.
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Sacher, Matthieu. "Méthodes avancées d'optimisation par méta-modèles – Applicationà la performance des voiliers de compétition." Thesis, Paris, ENSAM, 2018. http://www.theses.fr/2018ENAM0032/document.
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L’optimisation de la performance des voiliers est un problème difficile en raison de la complexité du systèmemécanique (couplage aéro-élastique et hydrodynamique) et du nombre important de paramètres à optimiser (voiles, gréement,etc.). Malgré le fait que l’optimisation des voiliers est empirique dans la plupart des cas aujourd’hui, les approchesnumériques peuvent maintenant devenir envisageables grâce aux dernières améliorations des modèles physiques et despuissances de calcul. Les calculs aéro-hydrodynamiques restent cependant très coûteux car chaque évaluation demandegénéralement la résolution d’un problème non linéaire d’interaction fluide-structure. Ainsi, l’objectif central de cette thèseest de proposer et développer des méthodes originales dans le but de minimiser le coût numérique de l’optimisation dela performance des voiliers. L’optimisation globale par méta-modèles Gaussiens est utilisée pour résoudre différents problèmesd’optimisation. La méthode d’optimisation par méta-modèles est étendue aux cas d’optimisations sous contraintes,incluant de possibles points non évaluables, par une approche de type classification. L’utilisation de méta-modèles à fidélitésmultiples est également adaptée à la méthode d’optimisation globale. Les applications concernent des problèmesd’optimisation originaux où la performance est modélisée expérimentalement et/ou numériquement. Ces différentes applicationspermettent de valider les développements des méthodes d’optimisation sur des cas concrets et complexes, incluantdes phénomènes d’interaction fluide-structure<br>Sailing yacht performance optimization is a difficult problem due to the high complexity of the mechanicalsystem (aero-elastic and hydrodynamic coupling) and the large number of parameters to optimize (sails, rigs, etc.).Despite the fact that sailboats optimization is empirical in most cases today, the numerical optimization approach is nowconsidered as possible because of the latest advances in physical models and computing power. However, these numericaloptimizations remain very expensive as each simulation usually requires solving a non-linear fluid-structure interactionproblem. Thus, the central objective of this thesis is to propose and to develop original methods aiming at minimizing thenumerical cost of sailing yacht performance optimization. The Efficient Global Optimization (EGO) is therefore appliedto solve various optimization problems. The original EGO method is extended to cases of optimization under constraints,including possible non computable points, using a classification-based approach. The use of multi-fidelity surrogates isalso adapted to the EGO method. The applications treated in this thesis concern the original optimization problems inwhich the performance is modeled experimentally and/or numerically. These various applications allow for the validationof the developments in optimization methods on real and complex problems, including fluid-structure interactionphenomena
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Fraga, Keith Jeffrey. "Explorations into protein structure with the knob-socket model." Scholarly Commons, 2016. https://scholarlycommons.pacific.edu/uop_etds/264.
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Protein sequences contain the information in order for a protein to fold to a unique compact, three-dimensional native structure. The forces that drive protein structures to form compact folds are largely dominated by burial of hydrophobic amino acids, which results in non-specific packing of amino acid side-chains. The knob-socket model attempts to organize side-chain packing into tetrahedral packing motifs. This tetrahedral motif is characterized with a three residues on the same secondary structure forming the base of the tetrahedron packing with a side-chain from a separate secondary structure. The base of the motif is termed the socket, and the other side-chain is called the knob. Here, we focus on extending the knob-socket model to understand tertiary and quaternary structure. First, single knobs sometimes pack into more than one socket in real structures. We focus on understanding the topology and amino acid preferences of these tertiary packing surfaces. The main results from the study of tertiary packing surfaces is that they have a preferred handedness, some interactions are ancillary to the packing interaction, there are specific amino preferences for specific positions in packing surfaces, and there is no relationship between side-chain rotamer of the knob packing into the tertiary packing surface. Next, we examine the application of the knob-socket to irregular and mixed packing in protein structure. The main conclusions from these efforts show canonical packing modes between secondary structures and highlight the important of coil secondary structure in providing many of the knobs for packing. Third, we investigate protein quaternary structure with a clique analysis of side-chain interactions. We identify a possible pseudo knob-socket interaction, and compare knob-socket interactions between tertiary and quaternary structure. Lastly, we discuss the workflow used in CASP12 to predict side-chain contacts and atomic coordinates of proteins.
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Acikgoz, Nazmiye. "Adaptive and Dynamic Meshing Methods for Numerical Simulations." Diss., Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/14521.
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For the numerical simulation of many problems of engineering interest, it is desirable to have an automated mesh adaption tool. This is important especially for problems characterized by anisotropic features and require mesh clustering in the direction of high gradients. Another significant issue in meshing emerges in unsteady simulations with moving boundaries, where the boundary motion has to be accommodated by deforming the computational grid. Similarly, there exist problems where current mesh needs to be adapted to get more accurate solutions. To solve these problems, we propose three novel procedures.
In the first part of this work, we present an optimization procedure for three-dimensional anisotropic tetrahedral grids based on metric-driven h-adaptation. Through the use of topological and geometrical operators, the mesh is iteratively adapted until the final mesh minimizes a given objective function. We propose an optimization process based on an ad-hoc application of the simulated annealing technique, which improves the likelihood of removing poor elements from the grid. Moreover, a local implementation of the simulated annealing is proposed to reduce the computational cost.
Many challenging unsteady multi-physics problems are characterized by moving boundaries and/or interfaces. When the boundary displacements are large, degenerate elements are easily formed in the grid such that frequent remeshing is required. We propose a new r-adaptation technique that is valid for all types of elements (e.g., triangle, tet, quad, hex, hybrid) and deforms grids that undergo large imposed displacements at their boundaries. A grid is deformed using a network of linear springs composed of edge springs and a set of virtual springs. The virtual springs are constructed in such a way as to oppose element collapsing.
Both frequent remeshing, and exact-pinpointing of clustering locations are great challenges of numerical simulations, which can be overcome by adaptive meshing algorithms. Therefore, we conclude this work by defining a novel mesh adaptation technique where the entire mesh is adapted upon application of a force field in order to comply with the target mesh or to get more accurate solutions. The method has been tested for two-dimensional problems of a-priori metric definitions as well as for oblique shock clusterings.
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Balasubramanian, Ganapathi Raman. "Low-order coupled map lattices for estimation of wake patterns behind vibrating flexible cables." Link to electronic thesis, 2003. http://www.wpi.edu/Pubs/ETD/Available/etd-0908103-105504.
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Thesis (Ph. D.)--Worcester Polytechnic Institute.<br>Keywords: fluid-structure interaction; low dimensional models; coupled map lattices; vortex shedding; cylinder wake patterns; flow control; multi-variable least squares algorithm; neural networks; adaptive estimation. Includes bibliographical references (p. 147-149).