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Статті в журналах з теми "612.015 77":

1

Talbot, Elizabeth A., Thomas A. Kenyon, Themba L. Moeti, Gary Hsin, Laura Dooley, Shenaaz El-Halabi, and Nancy J. Binkin. "HIV risk factors among patients with tuberculosis — Botswana 1999." International Journal of STD & AIDS 13, no. 5 (May 1, 2002): 311–17. http://dx.doi.org/10.1258/0956462021925126.

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To identify factors associated with HIV in Botswana, a standardized questionnaire was administered to 135 tuberculosis patients with known HIV status. HIV-positive patients were more likely than HIV-negative patients to: be female (45% vs 26% (adjusted prevalence odds ratio (aPOR)=3.8, 95% confidence interval (CI)=1.1-12.7)); be 26-35 years old (50% vs 19% (aPOR=2.7, CI=0.7-10.7)); be unmarried (91% vs 71% (aPOR=13.3, CI=2.5-72.7)); have higher income (24% vs 10% (aPOR=8.2, CI=1.6-42.9)); report separation from spouse/partner for work (63% vs 52% (aPOR=1.8, CI=0.5-6.2)); have 2 sex partners other than their regular partner (82% vs 67% (aPOR=1.8, CI=0.5-7.5)); and state that they or their partner drank alcohol before sex (77% vs 55% (aPOR=6.8, CI=1.9-24.1)). Only 22% of respondents used condoms during all of their past 10 sexual encounters. These data provide information for HIV prevention strategies.
2

Shakeel, Hassan Abdullah, Hamza Maqsood, Basit Ali, and Ali Raza Khan. "Association of chronic viral hepatitis with ABO blood groups and rhesus (Rh) factor." International Journal of Research in Medical Sciences 6, no. 4 (March 28, 2018): 1114. http://dx.doi.org/10.18203/2320-6012.ijrms20181265.

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Background: Chronic viral hepatitis includes hepatitis B and hepatitis C and is responsible for causing the deaths of millions of people all across the world each year. Although there are small studies in literature about association between ABO blood groups and chronic viral hepatitis, only few studies found relation between them. The objective of this case control study is to establish a relation between the host factors and these viral infections.Methods: This is a case control study on patients diagnosed with CVHB and CVHC. The study was conducted on 508 patients reported to Nishtar Hospital, Multan and Sheikh Zayd Hospital, Rahim Yar Khan, Pakistan.709 healthy blood donors were selected as a control group from Nishtar Hospital blood bank during December 2016 and December 2017.The results were subjected to SPSS v.20 for analysis using the chi square test. The patients and blood donors were also asked about certain demographic factors like age, sex and blood transfusions.Results: Among CVHB patients,173(100%), the distribution of blood groups was following: Group A, 38 (21.96%), B, 57 (32.94%), AB, 11 (6.35%), O, 67 (38.72%). 158 (91.32%) were Rh positive and 15 (8.67%) Rh negative. In CVHC patients, 335 (100%), the distribution was following: Group A, 69 (20.59%), B, 123 (36.71%), AB, 24 (7.16%), O, 119 (35.52%). 303 (90.44%) were Rh positive while 32 (9.55%) were Rh negative. In healthy blood donors, 167 (23.55%) were group A, 225 (31.73%) group B, 41(5.78%) group AB, 276 (38.92%) group O.632 (89.13%) were Rh positive and 77 (10.86%) Rh negative.Conclusions: There was no significant difference between blood groups(p>0.5) and Rh(p>0.5) with chronic viral hepatitis. However, it was also observed that the infections of HCV increase among (26-45) years old patients while the HBV infections increase with progression of age. Association of chronic viral hepatitis infection with blood group types needs more studies to get more knowledge about this aspect.
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Bagga, Neha, Poonam Elhence, Meenakshi Rao, Aasma Nalwa, Sudeep Khera, Jyotsna Naresh Bharti, Pratibha Singh, and Shashank Shekhar. "A prospective study of cervical lesions diagnosed by liquid based cytology in Western Rajasthan, India population." International Journal of Research in Medical Sciences 7, no. 12 (November 27, 2019): 4573. http://dx.doi.org/10.18203/2320-6012.ijrms20195521.

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Background: Carcinoma cervix is the second most common malignancy of women in India after breast cancer. The present study was conducted to determine the spectrum of cervical lesions by liquid-based cytology in Western Rajasthan population.Methods: It is a Prospective study on 1087 cervical samples carried over a period of 1 year. Cervical samples were taken and processed by SurePath™ LBC.Results: Of total 1087 cases 959 were negative for intraepithelial lesion or malignancy (88.22%). 88 cases (8.09%) were reported as unsatisfactory. Among the non- neoplastic cases- bacterial vaginosis was reported in 209 cases (21.8%), Candida in 77 cases (8.02%), both Candida and bacterial vaginosis in 12 cases (1.25%), reactive cellular changes in 193 cases (20.12%), and Trichomonas vaginalis in 01 case. Among pre-malignant and malignant lesions, 40 cases (4.17%) the distribution was as follows-atypical squamous cells of undetermined significance 16(1.67%), atypical squamous cell-cannot rule out high grade 08 cases (0.83%), Low grade squamous intraepithelial lesion 04 cases (0.42%), high grade squamous intraepithelial lesion 07 cases (0.73%), Atypical glandular cell favoring neoplastic 01 case (0.15%), and squamous cell carcinoma 04 cases (0.42%). Histopathological co-relation of premalignant and malignant lesions was further studied.Conclusions: Liquid based cytology is an effective screening and diagnostic procedure for cervical abnormalities. Among pre-malignant and malignant lesions, histo-pathological correlation increased with increased grade of severity of lesions. To the best of knowledge, this is the largest study of liquid based cytology in the Western Rajasthan.
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Aushev, Vasily N., Kalpana Gopalakrishnan, Susan L. Teitelbaum, Humberto Parada Jr, Regina M. Santella, Marilie D. Gammon, and Jia Chen. "Tumor expression of environmental chemical-responsive genes and breast cancer mortality." Endocrine-Related Cancer 26, no. 12 (December 2019): 843–51. http://dx.doi.org/10.1530/erc-19-0357.

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Environmental phenols and phthalates are common ingredients in personal care products and some have been implicated in breast cancer progression. We have previously identified genes differentially expressed in response to low-dose exposure to diethyl phthalate (DEP) and methyl paraben (MPB) in a rat model. Herein we explore if these genes are associated with breast cancer mortality in humans. We profiled MPB- and DEP-responsive genes in tumors by NanoString® from a population-based cohort of 606 women with first primary breast cancer among whom 119 breast cancer-specific deaths occurred within 15+ years of follow-up. For each gene, Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Results were validated in two publicly available datasets. The following results were obtained. From 107 DEP- and 77 MPB-responsive genes profiled, 44 and 30 genes, respectively, were significantly associated with breast cancer-specific mortality. Some top DEP-responsive genes are novel for breast cancer mortality, such as ABHD14B (for high-vs-low expression, HR 0.36, 95% CI: 0.2–0.5) and TMC4 (HR 0.37, 95% CI: 0.3–0.5); top hits for MPB (SLC40A1 (HR 0.37, 95% CI: 0.3–0.5) and NTN4 (HR 0.39, 95% CI: 0.3–0.6)) are well-known predictors of breast cancer survival. PLEKHA6 was another novel survival predictor, sensitive to hormonal receptor status (HR 0.5, 95% CI 0.3–0.9 for hormonal receptor-positive and HR 3.2, 95% CI 1.7–6.2 for -negative group). In conclusion, tumor expression of DEP- and MPB-responsive genes is associated with breast cancer mortality, supporting that exposure to these chemicals may influence the progression of breast cancer.
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Morschhauser, Franck, John Radford, Achiel Van Hoof, Umberto Vitolo, Pierre Soubeyran, Herve Tilly, Peter C. Huijgens, et al. "Phase III Trial of Consolidation Therapy With Yttrium-90–Ibritumomab Tiuxetan Compared With No Additional Therapy After First Remission in Advanced Follicular Lymphoma." Journal of Clinical Oncology 26, no. 32 (November 10, 2008): 5156–64. http://dx.doi.org/10.1200/jco.2008.17.2015.

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PurposeWe conducted an international, randomized, phase III trial to evaluate the efficacy and safety of consolidation with yttrium-90 (90Y)–ibritumomab tiuxetan in patients with advanced-stage follicular lymphoma in first remission.Patients and MethodsPatients with CD20+stage III or IV follicular lymphoma, who achieved a complete response (CR)/unconfirmed CR (CRu) or partial response (PR) after first-line induction treatment, were randomly assigned to receive90Y-ibritumomab tiuxetan (rituximab 250 mg/m2on day −7 and day 0 followed on day 0 by90Y-ibritumomab tiuxetan 14.8 MBq/kg; maximum of 1,184 MBq) or no further treatment (control). The primary end point was progression-free survival (PFS), which was calculated from the time of random assignment.ResultsA total of 414 patients (consolidation, n = 208; control, n = 206) were enrolled at 77 centers.90Y-ibritumomab tiuxetan consolidation significantly prolonged median PFS (after a median observation time of 3.5 years) in all patients (36.5 v 13.3 months in control arm; hazard ratio [HR] = 0.465; P < .0001) and regardless of whether patients achieved PR (29.3 v 6.2 months in control arm; HR = 0.304; P < .0001) or CR/CRu (53.9 v 29.5 months in control arm; HR = 0.613; P = .0154) after induction treatment. Median PFS with consolidation was prolonged in all Follicular Lymphoma International Prognostic Index risk subgroups. After90Y-ibritumomab tiuxetan consolidation, 77% of patients in PR after induction converted to CR/CRu, resulting in a final CR rate of 87%. The most common toxicity with90Y-ibritumomab tiuxetan was hematologic, and grade 3 or 4 infections occurred in 8% of patients.ConclusionConsolidation of first remission with90Y-ibritumomab tiuxetan in advanced-stage follicular lymphoma is highly effective with no unexpected toxicities, prolonging PFS by 2 years and resulting in high PR-to-CR conversion rates regardless of type of first-line induction treatment.
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Purvis, Peter, Calvin Chong, and Glen P. Lumis. "Recirculation of nutrients in container nursery production." Canadian Journal of Plant Science 80, no. 1 (January 1, 2000): 39–45. http://dx.doi.org/10.4141/p99-012.

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This study evaluated (a) the capacity of a computerized injector to deliver and recirculate nutrients in a container nursery, and (b) plant growth and nutrient status under this regime compared with non-recirculated methods of fertilization, using Dart's Gold ninebark (Physocarpus opulifolius L. 'Dart's Gold') potted in 6-L containers filled with a medium of pine bark, peat, and soil (75, 15, and 10%, by volume). The injector was programmed to deliver NH4-N (24 mg L−1), NO3-N (196 mg L−1), P (54 mg L−1), and K (235 mg L−1) and other nutrients, with or without recirculation. Plants grown with recirculated nutrients were placed on aluminium troughs to collect the leachate, which was pumped back to the injector, recharged [based on a target electrical conductivity (EC) value of 1.85 dS m−1], and returned to the crop. Additional plants were grown on a crushed stone base and fertilized (a) by the computerized injector without recirculation, (b) with water soluble Plant-Prod 20-8-20 (200 mg L−1 N; non-recirculated) delivered through a Dosatron proportioner, or (c) with incorporated, controlled release Nutricote 18-6-8, Type 140 (6.5 kg m−3). NH4-N, NO3-N, P, and K concentrations delivered by the computerized injector (recirculated and non-recirculated; mean over six dates, 3 July to 28 August 1997) were 50, 22, 41, and 39%, respectively, lower than targeted values. Electrical conductivity values were not significantly different from targeted. The pH values (6.2 – 6.4) were higher than targeted (6.0). The amounts of N, P, and K used were reduced by between 57 and 77% with recirculation compared to without. Notwithstanding reduced N, P, and K values, plants grew best with recirculated nutrients and least with non-recirculated liquid 20-8-20. Key words: Fertigation, Harrow Fertigation Manager, recycling, woody ornamentals
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Jiménez-Reyes, Pedro, Fernando Pareja-Blanco, Carlos Balsalobre-Fernández, Víctor Cuadrado-Peñafiel, Manuel A. Ortega-Becerra, and Juan J. González-Badillo. "Jump-Squat Performance and Its Relationship With Relative Training Intensity in High-Level Athletes." International Journal of Sports Physiology and Performance 10, no. 8 (November 2015): 1036–40. http://dx.doi.org/10.1123/ijspp.2014-0545.

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Purpose:To examine the relationship between the relative load in full squats and the height achieved in jump-squat (JS) exercises and to determine the load that maximizes the power output of high-level athletes.Method:Fifty-one male high-level track-and-field athletes (age 25.2 ± 4.4 y, weight 77. ± 6.2 kg, height 179.9 ± 5.6 cm) who competed in sprinting and jumping events took part in the study. Full-squat 1-repetition-maximum (1-RM) and JS height (JH) with loads from 17 to 97 kg were measured in 2 sessions separated by 48 h.Results:Individual regression analyses showed that JH (R2 = .992 ± .005) and the jump decrease (JD) that each load produced with respect to the unloaded countermovement jump (CMJ) (R2 = .992 ± 0.007) are highly correlated with the full-squat %1-RM, which means that training intensities can be prescribed using JH and JD values. The authors also found that the load that maximizes JS’s power output was 0%RM (ie, unloaded CMJ).Conclusions:These results highlight the close relationship between JS performance and relative training intensity in terms of %1-RM. The authors also observed that the load that maximizes power output was 0%1-RM. Monitoring jump height during JS training could help coaches and athletes determine and optimize their training loads.
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König, Matthias Alexander, and Volker Alexander Braunstein. "Tendon Repair Leads to better Long-Term Clinical Outcome than Debridement in Massive Rotator Cuff Tears." Open Orthopaedics Journal 11, no. 1 (July 25, 2017): 546–53. http://dx.doi.org/10.2174/1874325001611010546.

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Introduction: Massive tears in the rotator cuff are debilitating pathologies normally associated with loss of function and pain. Tendon reconstruction is seen as the standard treatment in order to preserve shoulder function and to inhibit cuff associated osteoarthritis. However, the effect on longer-term shoulder function and patient satisfaction is unknown. Material and Methods: 165 consecutive patients with massive tears were included. 57 debridement (mean age 61.9±8.7 years (range 43-77)) and 108 reconstruction (mean age 57.5±8.9 years (range 45-74)) cases could be followed up 2-4 (short-term), 5-6 (mid-term) and 8-10 (long-term) years after surgery. Evaluation was performed with the Constant, a modified ASES and the DASH score. Statistical analysis was done using Sigma-Stat Version 3.5 with a p-value<0.05 indicating statistical significant differences. Results: All three scoring systems showed no significant differences in the short-term follow-up for the two groups (mean values: Constant debridement/repair: 70±11.9/66±13.6; ASES debridement/repair: 22.3±3.3/ 23.3±3.3; DASH debridement/repair: 22.3±11.0/ 24.3±10.1). In the mid-term (Constant debridement/repair: 51±2.9/68.3±5.2; ASES debridement/repair: 20.3±1.3/24.3±1.7; DASH debridement/repair: 31.0±6.5/20.3±5.4) and long-term follow-up (Constant debridement/repair: 42.3±3.8 /60.7±2.6, ASES debridement/repair: 17.3±0.5/21.7±0.5, DASH debridement/repair: 41.3±6.2/25.0±1.4), rotator cuff reconstruction revealed better objective results and better patients’ satisfaction. Conclusion: Rotator cuff tendon repair leads to better long-term clinical outcome and subjective satisfaction compared to debridement. Tendon reconstruction should be considered as a treatment for patients suffering from massive rotator cuff tears, thus preserving shoulder function and by that means delay indication for reverse arthroplasty.
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Rabeeah, Zainab, Nida Shaikh, and Solveig Cunningham. "Changes in International Students’ Dietary Habits, Physical Activity and BMI During Their First Year After Relocating to the U.S." Current Developments in Nutrition 5, Supplement_2 (June 2021): 680. http://dx.doi.org/10.1093/cdn/nzab045_062.

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Abstract Objectives To identify changes in diet, physical activity and BMI after 3–6 months of relocation among international students in Georgia, USA. Methods Data were collected from 74 international students attending 2 urban universities in the Southeast. Students were interviewed within 10 days of arrival in the U.S and again 3–6 months later. Participants completed an interviewer-administered questionnaire that included a 26-item food frequency questionnaire, and questions on weekly physical activity, daily screen-time usage, sleep duration, and anthropometric measurements (body weight, height, and waist circumference), each measured twice and then averaged. Student t-test, Chi square and ANOVA analysis was done for participants who completed both waves (n = 74). Results Participants reported consistent food consumption within 3–6 months (mean difference &lt; 0.5 times per week). Physical activity frequency remained consistent (mean difference &lt; 0.5), but duration of almost all activities was increased. Participants reported increased hiking frequency and a significant increase in duration (frequency mean 0.05 to 0.09 times/week, 95% CI of (0.02–0.08) to (0.02–0.16), duration mean 21.1 to 117 minutes/week, 95% CI (14.1–28.0) to (94.7–138.5)). Screen time significantly increased (mean 4.2 to 7.0 hours/day, 95% CI (3.6–4.9) to (6.2–7.8)). Mean weight slightly increased (62.7 kg to 62.9 kg, 95% CI (60.5–65.0)), as did mean BMI (22.4 to 22.6, 95% CI (21.6–23.2)). However, around 37% of participants gained &gt; 10% of their baseline weight, while 32% lost &gt; 10% of their baseline weight. Almost half of participants (44.5%) reported that they had gained weight and 77% reported a decrease in their overall health. Conclusions Follow-up data suggests International students’ body weights changed drastically in a short time period which could potentially lead to negative health outcomes. Funding Sources None.
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Millis, Sherri Z., David Bryant, Gargi Dan Basu, Ryan Bender, Semir Vranic, Zoran Gatalica, and Nicholas J. Vogelzang. "Molecular profiling of infiltrating urothelial carcinoma of the bladder." Journal of Clinical Oncology 32, no. 4_suppl (February 1, 2014): 311. http://dx.doi.org/10.1200/jco.2014.32.4_suppl.311.

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311 Background: Infiltrating urothelial carcinoma (UC) is the most common variant of urinary bladder cancer. The prognosis for muscle infiltrating or metastatic UC of the bladder is poor with no major advances made in the last 20 years. We investigated a large cohort of such patients for specific genetic/biomarker alterations and compared them to other, less common urothelial malignancies. Methods: We reviewed 602 cases; 518 cases (86%) were locally advanced or metastatic UCs of the bladder and the remaining 84 cases (14%) were non-bladder UCs. Multiple methodologies for optimal assessment of biomarker expression (Caris Molecular Intelligence, Caris Life Sciences, Phoenix, AZ) were employed: Mutation analysis (Next-generation sequencing, Sanger, pyrosequencing, qPCR, RFLP), in-situ hybridization (fluorescent and chromogenic), immunohistochemistry, and RNA fragment analysis. Results: Bladder UC showed slightly higher rates of HER2/neu gene amplification (12% in bladder vs. 6% non-bladder, p=0.32) and EGFR gene amplification (22% vs. 12%, p=0.25). HER2/neu and EGFR protein expressions were more common in the bladder than in non-bladder sites (10% vs. 1%, p=0.03, and 77% vs. 60%, p=0.5, respectively). Pathogenic mutations in HER2/neu and EGFR were rare. Although c-Kit and c-Met receptor kinases were more frequently overexpressed in bladder than in non-bladder cancers (10% vs. 6% and 25% vs. 8%, respectively), activating mutations were also rare. PIK3CA and/or PTEN mutations were more frequently observed in non-bladder (27%) than in bladder UCs (21%). Non-bladder UC harbored high FGFR3 gene mutation (33%), which was not observed in any of the UC of the bladder (p=0.02). TP53 gene mutations were frequently identified in both bladder and in non-bladder cancers (49% vs. 27%, respectively, p=0.15), while KRAS was frequently mutated in the bladder adenocarcinomas (56%, p<0.001). Other therapeutically targetable biomarkers over-expressed in bladder UC compared to non-bladder UC included androgen receptor (16% vs. 8%, p=0.07) and MGMT (63% vs. 47%). Conclusions: Comprehensive molecular profiling of urothelial carcinoma identifies a number of potentially actionable targets, which can be managed by the novel treatment modalities.

Частини книг з теми "612.015 77":

1

Guelachvili, G., and N. Picqué. "Table 77. D2 16O (D16OD): Wavenumbers and intensities for the (011)–(010) transitions from 2475 to 3005 cm-1." In Non-linear Triatomic Molecules, 308–10. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-41449-7_79.

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