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Статті в журналах з теми "614.47 23":

1

Kroggel, Mark, James A. Schrader, and William R. Graves. "138 Nodulation Capacity of Rhizobia Isolated from Root Zones of Maackia amurensis in Two Chinese Forests." HortScience 35, no. 3 (June 2000): 413C—413. http://dx.doi.org/10.21273/hortsci.35.3.413c.

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Maackia amurensis Rupr. & Maxim. is a leguminous tree species possessing meritorious ornamental characteristics and is confirmed to associate with rhizobia that fix nitrogen, but few attempts to isolate symbiotically superior rhizobia have been made. Our goals were to isolate rhizobia from the root zones of indigenous trees of M. amurensis in two ecologically distinct forests in the Heilongjiang Province of China, characterize the rhizobia, and compare their effectiveness at causing nodulation of this host plant. Rhizobia were isolated and cultured from nodules that formed on seedlings grown in soils collected in May 1998, from the Maoershan (45°N, 127°E) and Liangshui (47°N, 128°E) Research Forests. Inoculants from each of the 160 isolates were applied to seedlings. A subset of 48 isolates that evoked the most nodules was partitioned by cluster analysis into 12 similarity groups based on measures of number of nodules (17.9 ± 6.5), the ratio of growth rate on two distinct media (2.26 ± 1.8), pH reaction as measured by absorption at 614 nm of bromthymol blue (0.98 ± 0.36), and tolerance to sodium chloride at 15 g/L (23 out of 48). By using single-isolate cultures of similar cellular concentration as inoculants, one isolate from each group and USDA 4349, an isolate obtained during previous research, are being compared for their capacity to infect and nodulate seedlings.
2

Munoz-Zuluaga, Carlos A., Armando Sardi, Michelle Sittig, Victoria Eskay, Carol Ann Nieroda, Farah El-Sharkawy, Arkadii Sipok, and Vadim Gushchin. "Long-term outcomes with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in peritoneal carcinomatosis from appendiceal cancer: An 18-year experience." Journal of Clinical Oncology 35, no. 15_suppl (May 20, 2017): 4098. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.4098.

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4098 Background: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) have become standard of care for patients with peritoneal carcinomatosis (PC) from appendiceal cancer (AC). We reviewed our experience and outcomes. Methods: A retrospective review of 614 CRS/HIPEC procedures from 1998-2016 was performed. Patient characteristics, surgical variables, and postoperative outcomes of first CRS/HIPEC were analyzed. Results: Two hundred ninety patients with PC from AC underwent 334 CRS/HIPEC’s. Median age at diagnosis and surgery was 52 (22-79) and 53 (23-81) years, respectively; 65% (187) were female. Prior surgical score was 0, 1, 2, and 3 in 20%, 38%, 37%, and 5%, respectively. Prior systemic chemotherapy was reported in 30% of patients. Median time from diagnosis to CRS/HIPEC was 4 months (0-182). Pre-operative tumor markers (CEA, CA-125, CA-19-9) were positive in 48% with one, two, and three positive markers in 21%, 15%, and 13% patients, respectively. Median Peritoneal Cancer Index was 29. Mitomycin-C was the HIPEC agent of choice. Mean operative time was 10 hours (R: 4-19) and median length of stay was 10 days (R: 4-93). Histology included 59% (171) peritoneal mucinous carcinomatosis (PMCA), 41% (119) disseminated peritoneal adenomucinosis (DPAM). Lymph nodes were positive in 47% PMCA. Complete cytoreduction rate was 87% (84% PMCA, 92% DPAM [p = 0.048]). Grade III-V complications occurred in 21%, with one 30-day mortality (0.3%). Overall, median progression-free survival (PFS) was 84 months with 5-year PFS of 56%. Median PFS was 43 months in PMCA and not reached in DPAM. Five year PFS was 40% PMCA and 82% DPAM (p < 0.001). Median overall survival (MOS) was 139 months with 61% 5-year OS. MOS was 53 months in PMCA and not reached in DPAM. Five year OS was 47% PMCA and 85% DPAM (p < 0.001). At 42-month median follow-up, 68% were alive (92 PMCA/103 DPAM) with 84% disease free (72 PMCA/92 DPAM), 28% died of disease (73 PMCA/7 DPAM). Conclusions: CRS/HIPEC is an effective treatment for patients with PC from AC providing meaningful long term survival in low and high grade tumors and should be considered the standard of care.
3

Rosenberg, Shoshana M., Ann H. Partridge, Philip Daniel Poorvu, Jacqueline N. Casillas, Patricia A. Ganz, Linda A. Jacobs, Mary S. McCabe, et al. "Fertility preservation use and outcomes among young adult cancer survivors." Journal of Clinical Oncology 36, no. 7_suppl (March 1, 2018): 115. http://dx.doi.org/10.1200/jco.2018.36.7_suppl.115.

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115 Background: Fertility is a critical survivorship issue for young adults (YA) with cancer. Data regarding use of fertility preservation (FP) and fertility outcomes in this population are limited. Methods: In 2013-2014, 868 patients, aged 18-39, 1-5 years post diagnosis (dx) of an invasive cancer completed a survey about the impacts of cancer and treatment including fertility. Descriptive statistics were used to characterize FP options pursued, reasons for not undergoing FP, and pregnancy outcomes. Logistic regression was used to identify factors associated with pre- treatment FP. Results: Median age at dx was 32. Most respondents were female (73%), married (61%), with a college degree (71%). Breast (28%), thyroid (15%), and lymphoma (13%) were the most common dx. 13% (77/614) of women and 36% (82/231) of men reported FP attempts prior to treatment, including 57% of testicular, 39% of lymphoma, 27% of leukemia, and 18% of breast cancer survivors. In men, sperm banking (96%) was the most common approach; in women, embryo (47%) and oocyte (23%) cryopreservation. Of those who did not pursue FP (N=686), 19% reported lack of information on risks/options as the reason. In multivariable analyses, FP was associated (p<0.05) with male gender, younger age, chemotherapy, being married, and having a college degree; survivors who had children prior to dx were less likely to pursue FP (Table). Of 60 men who tried to father a pregnancy, 42 (70%) were successful and 37 (88%) conceived naturally. Of 114 women who attempted pregnancy, 83 (73%) were successful, 76 (92%) conceived naturally. Conclusions: Some YA patients are not aware of treatment risks and FP options, indicating that fertility may be under-addressed. In our sample, nearly all patients who reported attempting pregnancy within 5 years of dx conceived naturally, suggesting that a risk stratified approach may help optimize use of FP services. [Table: see text]
4

Korsakova, Yu L., T. V. Korotaeva, E. Yu Loginova, E. E. Gubar, E. A. Vasilenko, A. A. Vasilenko, N. A. Kuznetsova, I. M. Patrikeeva, and E. L. Nasonov. "The prevalence of comorbid and concomitant diseases in psoriatic arthritis patients, data from Russian register." Rheumatology Science and Practice 59, no. 3 (July 15, 2021): 275–81. http://dx.doi.org/10.47360/1995-4484-2021-275-281.

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Psoriatic arthritis (PsA) is a heterogeneous inflammatory arthritis associated with psoriasis (Ps); it belongs to the group of spondyloarthritis and is accompanied by damage to both the spine and peripheral joints, as well as the development of enteritis and dactylitis. In addition to skin and joint damage, PsA has numerous comorbid conditions that are pathogenetically related to the underlying disease, such as inflammatory bowel disease (IBD) and autoimmune eye disease, as well as cardiovascular diseases, obesity and metabolic syndrome, diabetes, osteoporosis, malignancies, mental disorders, and various concomitant diseases. We present data of the prevalence of these pathological conditions among the cohort of PsA patients included in the Russian register.Objective – to study the prevalence of comorbid and concomitant diseases in PsA patients.Materials and methods. The Russian multicenter, observational study with retrospective and prospective data collection of PsA patients included 614 patients with the established diagnosis psoriatic arthritis, corresponding to the CASPAR criteria, from 39 subjects of the Russian Federation, female/male – 331 (54%)/283 (46%). The average age was 45.2±0.52 years, duration of PsA – 5.7±0.27 years, Ps – 15.71±0.56. Duration of observation period: January 2016 – November 26, 2019. The diagnosis of comorbid and concomitant diseases was confirmed by medical specialists in accordance with the ICD-10 code. The analysis of the frequency and structure (%) of these diseases was carried out.Results. The majority of PsA patients had limited Ps: the area of Ps skin lesion (BSA, Basic Surface Area) was less than 3% in 372 (61.5%) patients, BSA from 3% to 10% – in 185 (30.6%), BSA>10% – in 47 (7.8%). Comorbid and concomitant diseases were detected in 297 (48%) of 614 patients. 183 (61.6%) patients had 2 or more diseases in addition to Ps and PsA. Diseases of the circulatory system were detected in 229 (77.1%) PsA patients with comorbid and concomitant diseases (arterial hypertension – in 194 (65.3%), coronary heart disease – in 22 (7.4%)). Diseases of the endocrine system, metabolic disorders were detected in 156 (52.5%) patients with PsA (diabetes mellitus in 44 (14.8%), hyperlipidemia in 44 (14.8%), metabolic syndrome in 36 (12.1%), obesity in 7 (2.4%), and others). Gastrointestinal diseases were observed in 62 (20.9%) patients. Diseases of the biliary system – in 33 (11.1%) patients. Diseases of the musculoskeletal system and connective tissue that are not associated with PsA – in 44 (14.8%). Diseases of the genitourinary system – in 23 (7.7%) patients. Respiratory diseases – in 17 (5.7%) patients. Infectious diseases – in 11 (3.7%). Eye diseases were detected – in 10 (3.4%) patients. Hematological diseases were diagnosed in 6 (2.0%) patients. Depression – in 4 (1.3%) patients.Conclusions. Among 297 patients with PsA with comorbid and concomitant diseases, diseases of the circulatory system are the most common (in 77.1%), less often – diseases of the endocrine system, metabolic disorders (in 52.5%) and diseases of the digestive system (in 32%). Uveitis (2.7%), IBD (1.3%), and depression (1.3%) were rarely detected in our cohort. The majority of patients in the Russian registry had mild forms of Ps (61.5%), and severe Ps (BSA>10%) was observed only in 7.8%. Thus, PsA is associated with a high prevalence of comorbid and concomitant diseases, especially cardiovascular. When choosing a treatment, these diseases should be taken into account. In connection with the new possibilities of therapy, it is necessary to evaluate the potential impact of therapy on patients with comorbid and concomitant diseases in real clinical practice.
5

Tabak, Fehmi, Esra Zerdali, Ozlem Altuntaş, Alper Gunduz, Sibel Bolukcu, Bilgul Mete, Inci Y. Nakir, et al. "Efficacy and safety of co-formulated elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide in HIV-positive patients: real-world data." International Journal of STD & AIDS 32, no. 6 (February 18, 2021): 562–69. http://dx.doi.org/10.1177/0956462420983692.

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Objectives: Elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide (E/C/F/TAF) is a recommended and widely used regimen for HIV infection. In this study, we aimed to determine the efficacy and safety of E/C/F/TAF in people living with HIV (PLWH), who are either treatment-naïve or switched from any tenofovir disoproxil fumarate-containing regimen. For switched patients, we aimed to determine the impact of switching from tenofovir disoproxil fumarate (TDF) to TAF on lipid profile and kidney functions. Methods: ACTHIV-IST Study Group produced a database, and five dedicated HIV centres in Istanbul entered data of PLWH who switched from any TDF-containing regimen to E/C/F/TAF and treatment-naïve patients who were initiated with the E/C/F/TAF regimen between January 2017 and December 2019. Clinical findings, viral parameters, lipid studies, renal function tests, adverse events and adherence to the treatment were recorded in this prospective observational study. Results: The study included a total of 614 switched and treatment-naïve patients. Of 430 treatment-experienced patients, 89% (382) were men, and the mean age was 42 ± 12 years. Among them, 47% (181/382) self-identified as men who have sex with men (MSM). The median duration of HIV diagnosis was 54 ± 29 months. The median duration of E/C/F/TAF use was 20 ± 36 months and that of previous treatment was 23 ± 18 months. HIV-RNA was undetectable at baseline and month 12 in 84.1% (360/428) and 86.1% (328/381) of patients, respectively ( p > 0.05). Mean CD4 counts were 708 ± 287 cells/µL and 802 ± 305 cells/µL at baseline and month 12, respectively ( p < 0.001). Serum creatinine levels remained stable during the treatment period. Mean total cholesterol levels at baseline and month 12 were 172 and 211 mg/dL ( p < 0.01), LDL-cholesterol 104 and 138 mg/dL ( p < 0.01), HDL-cholesterol 39 and 49 mg/dL ( p < 0.01) and triglycerides 134 and 174 mg/dL ( p < 0.01), respectively. The treatment was generally well tolerated. Eight patients discontinued the therapy (drug interaction: 3; lost to follow-up: 1; pregnancy: 1; pulmonary tuberculosis: 1; side effect: 1; patient’s decision: 1). Of 184 treatment-naïve patients, 88% (162) were men, and the mean age was 36.5± 12 years. Among them, 50% (81/162) self-identified as MSM. The mean duration of HIV infection was 21.6 ± 17.1 months. The mean duration of E/C/F/TAF use was 16 ± 4 months. HIV-RNA was undetectable at baseline and month 12 in 1% and 89.1% of patients, respectively. Mean CD4 counts at baseline and month 12 were 469 ± 223 cells/µL and 740 ± 298 cells/µL, respectively. During the treatment period, creatinine levels remained stable. Total cholesterol, LDL-cholesterol, triglyceride and also HDL-cholesterol levels increased. Mean total cholesterol levels at baseline and month 12 were 167 and 211 mg/dL ( p < 0.01), LDL-cholesterol 108 and 143 mg/dL ( p < 0.01), HDL-cholesterol 41 and 47 mg/dL ( p < 0.01) and triglycerides 136 and 172 mg/dL, respectively ( p < 0.01). The treatment was generally well tolerated. Three patients discontinued the therapy (drug interaction: 1; non-responder: 1; patient’s decision: 1). Conclusion: Starting with or switching to E/C/F/TAF in PLWH effectively suppresses HIV infection, is associated with an increase in CD4 cell count and is well tolerated in a real-life setting. Renal functions remained stable during the treatment. E/C/F/TAF use was associated with an increase in LDL-cholesterol and triglyceride levels along with an increase in HDL-cholesterol levels.
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Ritenour, Andrew, Volodymyr Bondarenko, Robin L. Kelley, and David C. Sheridan. "Electrical Characterization of Large Area 800 V Enhancement-Mode SiC VJFETs for High Temperature Applications." Materials Science Forum 615-617 (March 2009): 715–18. http://dx.doi.org/10.4028/www.scientific.net/msf.615-617.715.

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Prototype 800 V, 47 A enhancement-mode SiC VJFETs have been developed for high temperature operation (250 °C). With an active area of 23 mm2 and target threshold voltage of +1.25 V, these devices exhibited a 28 m room temperature on-resistance and excellent blocking characteristics at elevated temperature. With improved device packaging, on-resistance and saturation current values of 15 m and 100 A, respectively, are achievable.
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Mastronardi, Luciano, Ahmed Elsawaf, Raffaelino Roperto, Alessandro Bozzao, Manuela Caroli, Michele Ferrante, and Luigi Ferrante. "Prognostic relevance of the postoperative evolution of intramedullary spinal cord changes in signal intensity on magnetic resonance imaging after anterior decompression for cervical spondylotic myelopathy." Journal of Neurosurgery: Spine 7, no. 6 (December 2007): 615–22. http://dx.doi.org/10.3171/spi-07/12/615.

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Object Areas of intramedullary signal intensity changes (hypointensity on T1-weighted magnetic resonance [MR] images and hyperintensity on T2-weighted MR images) in patients with cervical spondylotic myelopathy (CSM) have been described by several investigators. The role of postoperative evolution of these alterations is still not well known. Methods A total of 47 patients underwent MR imaging before and at the end of the surgical procedure (intraoperative MR imaging [iMRI]) for cervical spine decompression and fusion using an anterior approach. Imaging was performed with a 1.5-tesla scanner integrated with the operative room (BrainSuite). Patients were followed clinically and evaluated using the Japanese Orthopaedic Association (JOA) and Nurick scales and also underwent MR imaging 3 and 6 months after surgery. Results Preoperative MR imaging showed an alteration (from the normal) of the intramedullary signal in 37 (78.7%) of 47 cases. In 23 cases, signal changes were altered on both T1- and T2-weighted images, and in 14 cases only on T2-weighted images. In 12 (52.2%) of the 23 cases, regression of hyperintensity on T2-weighted imaging was observed postoperatively. In 4 (17.4%) of these 23 cases, regression of hyperintensity was observed during the iMRI at the end of surgery. Residual compression on postoperative iMRI was not detected in any patients. A nonsignificant correlation was observed between postoperative expansion of the transverse diameter of the spinal cord at the level of maximal compression and the postoperative JOA score and Nurick grade. A statistically significant correlation was observed between the surgical result and the length of a patient's clinical history. A significant correlation was also observed according to the preoperative presence of intramedullary signal alteration. The best results were found in patients without spinal cord changes of signal, acceptable results were observed in the presence of changes on T2-weighted imaging only, and the worst results were observed in patients with spinal cord signal changes on both T1- and T2-weighted imaging. Finally, a statistically significant correlation was observed between patients with postoperative spinal cord signal change regression and better outcomes. Conclusions Intramedullary spinal cord changes in signal intensity in patients with CSM can be reversible (hyperintensity on T2-weighted imaging) or nonreversible (hypointensity on T1-weighted imaging). The regression of areas of hyperintensity on T2-weighted imaging is associated with a better prognosis, whereas the T1-weighted hypointensity is an expression of irreversible damage and, therefore, the worst prognosis. The preliminary experience with this patient series appears to exclude a relationship between the time of signal intensity recovery and outcome of CSM.
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Sergueeva, Adelina, Galina Miasnikova, Ekaterina Lisina, Mehdi Nouraie, Sergei A. Nekhai, Tatiana Ammosova, Josef T. Prchal, Xu Zhang, and Victor R. Gordeuk. "Thrombotic Complications Are Associated with Phlebotomy Therapy in Patients with Chuvash Polycythemia." Blood 126, no. 23 (December 3, 2015): 936. http://dx.doi.org/10.1182/blood.v126.23.936.936.

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Abstract Background: In Chuvash polycythemia (CP) (Problemi Gematologii I Perelivaniya Krovi 1974, 10:30), impaired degradation of hypoxia inducible factor (HIF)-1α and HIF-2α from a homozygous germline VHLR200W mutation leads to augmented hypoxic responses during normoxia (Nat Genet 2002, 32:614). In addition to elevated hematocrit, CP is marked by leg varices, benign vertebral hemangiomas, decreased systemic blood pressure, increased systolic pulmonary artery pressure, and by the defining phenotypes of thrombosis and early mortality (Blood 2004, 103:3924; Haematologica 2012, 97:193). There is no effective therapy. While phlebotomy has been recommended for idiopathic polycythemia by the British Committee for Standards in Haematology (Br J Haematol 2005, 130:174) and is administered to some CP patients, its benefits are unknown. Phlebotomy-induced iron deficiency inhibits PHD2 enzyme, the principal negative regulator of HIFs, which further augments hypoxic responses. This affects the transcription of many genes (BCMD 2014, 52:35). Hypoxia-regulated IRAK1 is augmented in inflammation and may promote thrombosis (Circ Res. 2013, 112:103). Methods: 165 patients with CP were enrolled in a registry between 2001 and 2009 after providing written informed consent. Survival analysis was used to examine the predictors of new thrombosis and death during the follow-up period. mRNA from peripheral blood mononuclear cells (PBMCs) was profiled by Affymetrix Human Exon 1.0 ST Array in 42 of the subjects. Results: The median age at enrollment was 35 years and 90 participants were females, 25 had a history of one thrombosis, 5 of two thromboses and 3 of three thromboses. In the year prior to study entry, 72 had received phlebotomy therapy (Table 1). In July 2015 the median follow-up was 9.0 years (range 1-14.5). During this follow-up period, 30 (18.2%) participants had one new thrombosis, 6 (3.6%) had two new thromboses and 17 (10.3%) died. The median age of death was 55 years (range 16-76) and deaths were related to thrombotic cerebrovascular accident (n = 4), myocardial infarction (n = 4), mesenteric or portal vein thrombosis (n = 3), other major thromboembolic events (n = 2) and trauma or unknown cause (n = 2). Baseline characteristics of older age, prior thrombosis, pentoxifylline treatment, smoking and splenomegaly were independently associated with greater thrombosis risk during follow-up (P < 0.003). After adjustment for these variables, the estimated probability of new thrombosis at 10 years was 26% in those receiving phlebotomies compared to 12% in those not phlebotomized (log rank P = 0.014) (Figure 1). There was also a trend for increased risk of death with phlebotomy: estimated probability 8.7% versus 3.7% (P = 0.15). Examination of gene transcripts affecting thrombosis by logistic regression identified 12 protective and 16 risk genes at 5% false discovery rate. Upregulation of two mRNAs was of singular significance: 1) IL1RAP, a proximal signaling adaptor of IRAK1 (Immunity 1997, 7: 837) and 2) THBS1, encoding thrombospondin1 (Blood 2015, 125: 399). Both genes have known roles in thrombosis promotion and we previously reported that THBS1 is upregulated in CP (BCMD 2014, 52:35). Further analysis revealed a further upregulation of THBS1 in patients with baseline history of phlebotomy (β=0.41, P=0.046). Conclusion: These findings underscore a high rate of thrombosis and death in patients with CP and reveal a potential role of increased IRAK1/IL1RAP signaling in these complications. They raise the possibility that phlebotomy therapy has a detrimental rather than beneficial effect, possibly contributed to by increased THBS1 expression. Table 1. Baseline characteristics by phlebotomy in the year prior to enrollment. Results in median (interquartile range) or n (%); four without phlebotomy data. No phlebotomy N=89 Received phlebotomy N=72 Age (years) 32 (18-48) 37 (26-49) 0.08 Female gender, n (%) 52 (58%) 34 (47%) 0.16 Smoking, n (%) 18 (20%) 24 (33%) 0.060 History of thrombosis, n (%) 20 (23%) 12 (17%) 0.4 Splenomegaly, n (%) 2 (2.3%) 2 (2.8%) 0.8 ASA treatment, n (%) 27 (30%) 36 (50%) 0.011 Pentoxifylline, n (%) 7 (7.9%) 17 (23.6%) 0.005 BMI (kg/m2) 20.4 (18.3-22.9) 21.6 (19.9-24.6) 0.010 Systolic BP (mm Hg) 109 (100-123) 118 (105-124) 0.6 Diastolic BP (mm Hg) 76 (68-84) 78 (71-83) 0.8 Hemoglobin (g/dL) 18.1 (16.4-21.0) 17.9 (16.0-19.8) 0.5 WBC (per uL) 5.7 (4.6-7.0) 5.5 (4.6-6.7) 0.9 Figure 1. Figure 1. Disclosures No relevant conflicts of interest to declare.
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Fung, Isaac Chun-Hai, Elizabeth B. Blankenship, M. Elizabeth Goff, Lindsay A. Mullican, Kwun Cheung Chan, Nitin Saroha, Carmen H. Duke, Marina E. Eremeeva, King-Wa Fu, and Zion Tsz Ho Tse. "Zika-Virus-Related Photo Sharing on Pinterest and Instagram." Disaster Medicine and Public Health Preparedness 11, no. 6 (March 23, 2017): 656–59. http://dx.doi.org/10.1017/dmp.2017.23.

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AbstractObjectivePinterest (San Francisco, CA) and Instagram (Menlo Park, CA) are 2 popular photo-sharing social media platforms among young individuals. We assessed differences between Instagram and Pinterest in relaying photographic information regarding Zika virus. Specifically, we investigated whether the percentage of Zika-virus-related photos with Spanish or Portuguese texts embedded therein was higher for Instagram than for Pinterest and whether the contents of Zika-virus-related photos shared on Pinterest were different from those shared on Instagram.MethodsWe retrieved and manually coded 616 Pinterest (key words: “zika” AND “virus”) and 616 Instagram (hashtag: #zikavirus) photos.ResultsAmong the manually coded samples, 47% (290/616) of Pinterest photos and 23% (144/616) of Instagram photos were relevant to Zika virus. Words were embedded in 57% (164/290) of relevant Pinterest photos and all 144 relevant Instagram photos. Among the photos with embedded words, photos in Spanish or Portuguese were more prevalent on Instagram (77/144, 53%) than on Pinterest (14/164, 9%). There were more Zika-virus-related photos on Instagram than on Pinterest pertinent to Zika virus prevention (59/144, 41%, versus 41/290, 14%; P<0.0001), the effects of Zika virus on pregnancy (27/144, 19%, versus 32/290, 11%; P=0.04), and Zika-virus-associated deaths (4/144, 2%, versus 0/290, 0%; P=0.01).ConclusionsPinterest and Instagram are similar platforms for Zika virus prevention communication. (Disaster Med Public Health Preparedness. 2017;11:656–659)
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Krupa, Michał. "Recenzje." Z Badań nad Książką i Księgozbiorami Historycznymi 10 (December 11, 2019): 381–96. http://dx.doi.org/10.33077/uw.25448730.zbkh.2016.130.

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Česko-polské kazatelské vztahy ve středověku, ed. Krzysztof Bracha, Martin Nodl, „Colloquia Mediaevalia Pragensia”, 16, Praha 2016: Filosofi a, ss. 152, ISBN 978-80-7007-451-0 – Justyna Dziadek [381-385] Pomeranica XVIII wieku w zbiorach Archiwum Państwowego w Szczecinie. Katalog, oprac. Janina Kosman, Szczecin: Wydawnictwo „Dokument” Oficyna Archiwum Państwowego w Szczecinie, 2016, ss.191, il., ISBN 978-83-64-642-23-4 – Edward Potkowski [385-390] Katalog starodruków Biblioteki Muzeum Polskiego w Ameryce = Catalogue of Early Printed Books from The Polish Museum of America Library, oprac. Fryderyk Rozen, Warszawa: Biblioteka Narodowa, 2015, ss. 47, 28 il., ISBN 978-83-7009-613-7 – Elżbieta Maruszak [390-393] Ewa Repucho, Typografia kompletna. Kultura książki w twórczości Leona Urbańskiego, Wrocław: Oficyna Wydawnicza Atut, 2016, ss. 328, ISBN 978-83-7977-209-4 – Agnieszka Chamera-Nowak [394-396]

Частини книг з теми "614.47 23":

1

Kuner, Christopher. "Article 47 Binding corporate rules." In The EU General Data Protection Regulation (GDPR). Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780198826491.003.0087.

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Recital 6; Articles 13(1)(f) and 14(1)(f) (Information to a data subject); Article 15(1)(c) (Right to access information about data recipients in third countries); Article 23(2)(d) (Member States can restrict individuals’ rights but must provide for safeguards to prevent abuse or unlawful transfer) (see too recital 153); Article 28(3)(a) (Provisions of a data processing agreement stipulating controller’s instructions regarding data transfers); Articles 30(1)(e) and 30(2)(c) (Internal records about data transfers); Article 40(2)(j) (Data transfer codes of conduct); Article 58(3)(j) (Power of supervisory authorities to approve BCRs); Article 64(1)(f) (Opinion of the Board regarding the approval of BCRs); Article 70(1)(c) (Advice by the Board to the Commission regarding the format and procedures for the exchange of information for BCRs); Article 83(5)(c) (Fines for non-compliance with data transfer restrictions).
2

Taber, Douglass F. "Substituted Benzenes: The Reddy Synthesis of Isofregenedadiol." In Organic Synthesis. Oxford University Press, 2015. http://dx.doi.org/10.1093/oso/9780190200794.003.0062.

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Jianbo Wang of Peking University (Org. Lett. 2011, 13, 4988) and Patrick Y. Toullec and Véronique Michelet of Chimie ParisTech (Org. Lett. 2011, 13, 6086) developed conditions for the electrophilic acetoxylation of a benzene derivative 1. Seung Hwan Cho and Sukbok Chang of KAIST (J. Am. Chem. Soc. 2011, 133, 16382) and Brenton DeBoef of the University of Rhode Island (J. Am. Chem. Soc. 2011, 133, 19960) devised protocols for the electrophilic imidation of a benzene derivative 3. Vladimir V. Grushin of ICIQ Tarragona devised (J. Am. Chem. Soc. 2011, 133, 10999) a simple protocol for the cyanation of a bromobenzene 6 to the nitrile 7. Hua-Jian Xu of the Hefei University of Technology (J. Org. Chem. 2011, 76, 8036) and Myung-Jong Jin of Inha University (Org. Lett. 2011, 13, 5540) established conditions for the efficient Heck coupling of a chlorobenzene 8. Jacqueline E. Milne of Amgen/Thousand Oaks reduced (J. Org. Chem. 2011, 76, 9519) the adduct from the addition of 11 to 12 to deliver the phenylacetic acid 13. Jeffrey W. Bode of ETH Zurich effected (Angew. Chem. Int. Ed. 2011, 50, 10913) Friedel-Crafts alkylation of 14 with the hydroxamate 15 to give the meta product 16. B.V. Subba Reddy of the Indian Institute of Chemical Technology, Hyderabad took advantage (Tetrahedron Lett. 2011, 52, 5926) of the directing ability of the amide to effect selective ortho acetoxylation of 17. Similarly, Frederic Fabis of the Université de Caen Basse-Normandie used (J. Org. Chem. 2011, 76, 6414) the methoxime of 19 to direct ortho bromination, leading to 20. Teck-Peng Loh of Nanyang Technological University showed (Chem. Commun. 2011, 47, 10458) that the carbamate of 21 directed ortho C–H functionalization to give the ester 23. Yoichiro Kuninobu and Kazuhiko Takai of Okayama University rearranged (Chem. Commun. 2011, 47, 10791) the allyl ester 24 directly to the ortho-allylated acid 25. Youhong Hu of the Shanghai Institute of Materia Medica (J. Org. Chem. 2011, 76, 8495) and Graham J. Bodwell of Memorial University (J. Org. Chem. 2011, 76, 9015) condensed a chromene 26 with a nucleophile 27 to give the arene 28. C.V. Ramana of the National Chemical Laboratory prepared (Tetrahedron Lett. 2011, 52, 4627) the arene 31 by condensing 29 with 30 with high regioselectivity.
3

Cieślak-Kopyt, Małgorzata. "Elementy obrządku pogrzebowego." In Ocalone Dziedzictwo Archeologiczne, 83–87. Wydawnictwo Profil-Archeo; Muzeum im. Jacka Malczewskiego w Radomiu, 2020. http://dx.doi.org/10.33547/oda-sah.10.zn.04.

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A total of 65 Przeworsk culture features were discovered in the Żelazna Nowa cemetery. This number included a rectangular groove feature, urned cremations (6), alleged/damaged urned cremations (14), unurned cremations (14), alleged/fully or partly damaged unurned cremations (27), pits containing no bone material (4), undtermined cremations (2), pits containing no archeological material (1). All of the explored burials are cremations. However, a more detailed analysis encounters problems due to the state of preservation of the graves. Features 3, 19A and 19B, 30, 33, 37, 39 have been confidently identified as urned cremations. In many other features fragments of ceramic vessels were found, which may be remains of damaged urns: 18, 21, 23, 25, 31, 35, 44, 46, 47, 48, 49, 56, 57, and 58. Certain unurned cremations are 4, 6, 7, 8, 11–13, 15–17, 22, 24, 32, and 34. The interpretation of the remaining features is uncertain. Among the features uncovered in the cemetery were pits containing no bones: 5, 60, 61, 62, as well as pits containing no archaeological material at all: 55. The majority of unurned cremations contained pyre debris, while no such remains were observed in the following damaged unurned cremations: 15, 40–42, 45, 61, 62. There were a few cases of double burials identified. Three unurned cremations (6, 13, 15) and one urned cremation (39) contained bones of Infans I and an undetermined individual, while feature 19 contained two urns with individual burials: Infans II and an undetermined individual. Urned cremations, and one alleged unurned cremation (56), are distinguished by a higher standard of furnishing and a considerably larger amount of bone remains. This can be given two interpretations: a higher status of those buried there, or different rituals used for urned and unurned cremations. In two graves the urn was covered with an upturned vessel (features 33 and 37). In one case, an apotropaic behaviour characteristic of the Przeworsk culture was recorded, involving driving sharp objects into the pit’s bottom: in grave 41 these were two spearheads.
4

Taber, Douglass F. "C–N Ring Construction: The Glorius Synthesis of ent-Monomorine." In Organic Synthesis. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190646165.003.0054.

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Ryan Gilmour of the Westfälische Wilhelms-Universität Münster employed (Chem. Eur. J. 2014, 20, 794) an organocatalyst to direct the enantioselective aziridination of 1 to 2. Vanessa Kar-Yan Lo and Chi-Ming Che of Hong Kong University devised (Angew. Chem. Int. Ed. 2014, 53, 2982) a Ru catalyst for the enantioselective aziridi­nation (not illustrated) of terminal alkenes. Shu-Li You of the Shanghai Institute of Organic Chemistry and Aiwen Lei of Wuhan University described (Angew. Chem. Int. Ed. 2014, 53, 2443) the Pd-mediated carbonylation of 3 to the β-lactam 4. Professor You reported (J. Am. Chem. Soc. 2014, 136, 6590) the enantioselective allylation of a pyrrole 5 with 6 to give the imine 7. Maria-Paz Cabal and Carlos Valdés of the University of Oviedo showed (Eur. J. Org. Chem. 2014, 1672) that the cycliza­tion of 8 to 9 proceeded with predictable high diastereocontrol. In one pot, Darren J. Dixon of the University of Oxford combined (ACS Catal. 2014, 4, 634) 10 and 11 to give 12 in high ee. The addition of 13 to 14 to give 15 described (Nature Chem. 2014, 6, 47) by Takashi Ooi of Nagoya University set two adjacent quaternary centers with control of both relative and absolute configuration. Scott E. Denmark of the University of Illinois devised (J. Am. Chem. Soc. 2014, 136, 8915) a catalyst for the enantioselective electrophilic cyclization of 16 to 17 with control of sidechain stereochemistry. Using commercial acetone cyanohydrin 19, Christian V. Stevens of Ghent University cyclized (Eur. J. Org. Chem. 2014, 1296) 18 to the nitrile 20. George W. J. Fleet, also of the University of Oxford, used (Eur. J. Org. Chem. 2014, 2053) similar conditions to convert the sugar-derived acetonide 21 into 22. Michael B. Tropak of the University of Toronto and Dilip P. Dhavale of the University of Pune showed (J. Org. Chem. 2014, 79, 4398) that the nitrone derived from 21 added to an alkene 23 with high facial selectivity, leading to the piperidine 24. In the course of a synthesis of syringolin A, Satoshi Ichikawa of Hokkaido University effected (Angew. Chem. Int. Ed. 2014, 53, 4836) intramolecular Ugi three-component coupling of the isonitrile 25, the acid 26, and the amine 27, leading to the macrolactam 28.

Тези доповідей конференцій з теми "614.47 23":

1

Sebastian, Ajit, Dhanya Susan Thomas, Anitha Thomas, Rachel Chandy, and Abraham Peedicayil. "Outcome of bowel resection in women with advanced ovarian carcinoma." In 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685310.

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Aim: To evaluate the mortality and morbidity related to bowel resection in women with advanced ovarian carcinoma. Methods: Retrospective case series of 47 women with stage III and IV carcinoma ovary who underwent bowel resection, over the period of 5 years from Jan 2011 to Dec 2015. The disease free survival was assessed and the prognostic factors for disease free survival was also analysed by bivariate analysis. Results: In this cohort 64% (30/47) had primary debulking, 21% (10/47) had interval debulking and 15% (7/47) had secondary debulking. The mean period of follow up was 23 months (1 – 45 month). The mortality was 15% (7/47), while major morbidity like anastomotic leak were nil. The three variables considered for mortality were relaparotomy, paralytic ileus and surgical site infection. 6% (3/47) had relaparotomy, 21% (10/47) had paralytic iileus and 15% (7/47) had surgical site infection. The overall morbidity was 42.5% (20/47). A total 34% (16/47) of patients had stoma. 79% (37/47) patients had optimal debulking. Conclusion: Bowel resection in optimally selected cases of advanced carcinoma ovary is a good option with limited mortality and morbidity. Often, bowel resection is the only way to achieve optimal debulking.
2

Soni, Tej Prakash, Aaditya Prakash, Tinku Takia, and Jaishree Goyal. "Radiotherapy after hysterectomy in carcinoma cervix: Audit from a tertiary care cancer hospital in India’s largest state “Rajasthan”." In 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685274.

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Purpose: To explore the reasons of hysterectomy and indications of post-hysterectomy radiotherapy in carcinoma cervix cases. Methods: From January 2013 to May 2015, medical records of 64 cases of carcinoma cervix (post-hysterectomy) who were referred for radiotherapy to our hospital were analyzed retrospectively. Results: Medical records of 64 cases were reviewed. The median age was 47 years. In 45% of females hysterectomy was done in towns, but in majority of cases (55%) hysterectomy was done in different cities of Rajasthan. Simple hysterectomy was done in 31 of (48%) cases. Wertheim’s hysterectomy was done in remaining 33 cases (52%). 15 cases (23%) were treated by IMRT technique, while remaining 87% cases were treated by 3DCRT technique to dose of 50 Gy in 25 fractions followed by CVS brachytherapy. All cases also received concurrent chemotherapy. Reason for hysterectomy was analyzed. In 32 (50%) cases, biopsy from gross lesion at cervix or PAP smear test was not done before surgery. In 32 cases (50%) understaging of the tumor or inadequate staging before hysterectomy was performed. Histopathology report analysis revealed that in 9 cases (14%) primary tumor size was less than 4 cm, in 27 cases (64%) there was no comment on pT size, in 22% cases primary tumor was larger than 4 cm. Surprisingly in one case the pT size was 7 cm. LVSI was not seen in 18 cases (28%), positive in 20 case (31%) and with no comment in 26 cases. More than 50% of stroma thickness was involved in 54 cases (84%), and in remaining 10 cases there was no comment on stroma invasion. In 33 cases (52%) pelvic lymphadenectomy was done, in 48% cases lymph nodes were not addressed in surgery. In 36 cases (56%) pelvic lymph node metastasis was seen either in preoperative imaging (USG/CT scan) or in histopathology. Median follow-up duration was 6 months. Locoregional failure was seen in 10 cases (16%), 6 cases (9%) also developed distant metastasis. Conclusion: Failure to perform biopsy from gross lesion at or under staging/inadequate staging before surgery was the main reasons for inappropriate hysterectomy for carcinoma cervix. Inappropriate hysterectomy followed by chemo-radiotherapy resulted in poor tumor control rate as in our study, 1 out of every 4 patients failed loco-regionally with median follow up of 6 months. Strict adherence to guidelines for cervical cancer diagnosis and treatment is advised to prevent inappropriate hysterectomy.
3

Aiach, M., M. Roncato, G. Sorin, P. Dezellus, and J. N. Fiessinger. "A NEW AT III VARIANT WITH DEFECTIVE PROTEASE BINDING SITE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642941.

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A decreased plasma anti thrombin activity in presence heparin cofactor (hep-cof) or in absence of heparin (AT) was discovered in a 47 year-old patient presenting with recurrent venous thromboembolism. The immunoreactive material (AT III-IR) was normal. The same biological abnormalities were found in two relatives of the patient, leading to the diagnosis of hereditary qualitative AT III deficiency.The propositus'AT III was coeluted with normal AT III from an heparin sepharose column. An additional step of ion-exchange chromatography on a Mono Q column using a FPLC system (Pharmacia, Bois d'Arcy, France) allowed the purification of a protein which was homogenous in SDS - 10 % polyacrylamide electrophoresis gel (PAGE). AT III purified from propositus'plasma, normal plasma and the plasma of a patient known to have an AT III variant with defective protease binding (1) were compared. The specific activities measured as hep-cof AT or factor Xa inhibition in absence of heparin (anti Xa) were respectively 6.4 and 4.8 U/mg for the propositus 'AT III and 13.6 and 8.5 U/mg for the normal AT III (one unit is the activity of 1 ml of a plasma pool prepared from 30 normal subjects). The formation of protease inhibitor complexes was studied by incubating purified AT III with purified thrombin (in molar ratio 1:4, 1:2, 1:1) during 5 minutes at 37 °C and submitting the mixture to PAGE. The densitometric scan showed that in equimolar ratio the percentage of an AT III-thrombin complex (with 92 kA Mr) reaches 70 for normal AT III and respectively 30 and 23 for the propositus'AT III and the already described variant AT III Charlevillé (1). A 70 % proportion of free AT III (58 kA) remained for the propositus. As previously observed an unidentified 63 kA compound appeared for AT III Charleville. This results strongly suggest that in the patient described here, half th the AT III molecules are normal, the others having a defective protease binding site. We propose to call this new variant AT III Avranches, the town where the propositus was born.(1) Thrombosis Research 1985, 39, 559-570.

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