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Статті в журналах з теми "72.01(477) (042.3)"

Автор: Grafiati

Опубліковано: 30 травня 2022

Оновлено: 31 липня 2025

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1

Coates, L. C., R. B. Warren, C. T. Ritchlin, et al. "POS1022 BIMEKIZUMAB SAFETY AND EFFICACY IN PATIENTS WITH PSORIATIC ARTHRITIS: 3-YEAR RESULTS FROM A PHASE 2b OPEN-LABEL EXTENSION STUDY." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 779–80. http://dx.doi.org/10.1136/annrheumdis-2021-eular.124.

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Background:Bimekizumab (BKZ), a monoclonal antibody inhibitor of interleukin (IL)-17A and IL-17F, demonstrated clinical improvements in joint and skin outcomes up to 108 weeks (wks) in patients (pts) with active psoriatic arthritis (PsA).1,2Objectives:To report up to 3-year safety and efficacy of BKZ in pts with active PsA from a 48-week phase 2b dose-ranging study (BE ACTIVE; NCT02969525) and its open-label extension (OLE; NCT03347110).Methods:BE ACTIVE and OLE study design has been described previously.1 All OLE pts received BKZ 160 mg Q4W, irrespective of prior dosing regimen. Treatment-eme

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2

Zhao, Kanhao, Hua Xie, Gregory A. Fonzo, Nancy B. Carlisle, Ricardo S. Osorio, and Yu Zhang. "Dementia Subtypes Defined Through Neuropsychiatric Symptom–Associated Brain Connectivity Patterns." JAMA Network Open 7, no. 7 (2024): e2420479. http://dx.doi.org/10.1001/jamanetworkopen.2024.20479.

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ImportanceUnderstanding the heterogeneity of neuropsychiatric symptoms (NPSs) and associated brain abnormalities is essential for effective management and treatment of dementia.ObjectiveTo identify dementia subtypes with distinct functional connectivity associated with neuropsychiatric subsyndromes.Design, Setting, and ParticipantsUsing data from the Open Access Series of Imaging Studies-3 (OASIS-3; recruitment began in 2005) and Alzheimer Disease Neuroimaging Initiative (ADNI; recruitment began in 2004) databases, this cross-sectional study analyzed resting-state functional magnetic resonance

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3

Walker, C. D., R. W. Rivest, M. J. Meaney, and M. L. Aubert. "Differential activation of the pituitary-adrenocortical axis after stress in the rat: use of two genetically selected lines (Roman low- and high-avoidance rats) as a model." Journal of Endocrinology 123, no. 3 (1989): 477–85. http://dx.doi.org/10.1677/joe.0.1230477.

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ABSTRACT We have examined the activation of the pituitary-adrenal axis in two lines of rats, the Roman high (RHA)- and low (RLA)-avoidance rats known to be emotionally different. These rats are selected for rapid acquisition of a conditioned avoidance response (RHA) compared with failure to acquire this response (RLA). In this study the endocrine response (ACTH, corticosterone, aldosterone) of RLA and RHA rats to two types of stress was examined: exposure to openfield stress for 10 min (Op) or exposure to ether vapours for 3 min (E). Basal plasma ACTH concentrations were lower in RLA than in R

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4

McCarthy, Philip L., Theresa Hahn, Anna Hassebroek, et al. "Significant Improvement In Overall Survival In Patients Who Underwent Autologous Hematopoietic Cell Transplant In the US or Canada Between 1994 and 2005." Blood 116, no. 21 (2010): 2389. http://dx.doi.org/10.1182/blood.v116.21.2389.2389.

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Abstract Abstract 2389 Autologous hematopoietic cell transplantation (autoHCT) is standard therapy for high-risk hematologic disorders and solid tumors. We assessed whether overall survival (OS) at Day 100, which represents early transplant-related mortality (TRM), and at one year, which represents disease-related mortality and later TRM, had changed over time. The study population was derived from patients undergoing 68,404 first autoHCTs between 1994–2005 in US and Canadian centers reported to the CIBMTR. Statistical significance was measured using Ptrend over 6 time cohorts to test whether

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5

Combe, B., Y. Tanaka, P. Emery, et al. "POS0679 CLINICAL OUTCOMES UP TO WEEK (W) 48 IN THE ONGOING FILGOTINIB (FIL) LONG-TERM EXTENSION (LTE) TRIAL OF RHEUMATOID ARTHRITIS (RA) PATIENTS (pts) WITH INADEQUATE RESPONSE (IR) TO METHOTREXATE (MTX) INITIALLY TREATED WITH FIL OR ADALIMUMAB (ADA) DURING THE PHASE 3 PARENT STUDY (PS)." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 615–16. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1641.

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BackgroundThe preferential Janus kinase-1 inhibitor FIL is approved for treatment of moderate to severe active RA in Europe and Japan.ObjectivesEfficacy and safety of FIL were assessed in pts with IR to MTX who completed a Phase 3 trial (NCT02889796)1 and enrolled in an LTE (NCT03025308).MethodsPts completing the PS1 on study drug were eligible to enter the LTE (data cutoff: June 1, 2020). Median exposure: 2.2 years (y). Efficacy data to W48 are reported for 4 treatment groups (all with background MTX): pts receiving FIL 200 mg (FIL200) or FIL 100 mg (FIL100) in the PS and continuing their dos

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6

TUMMARUK, P., W. TANTASUPARUK, M. TECHAKUMPHU, and A. KUNAVONGKRIT. "Seasonal influences on the litter size at birth of pigs are more pronounced in the gilt than sow litters." Journal of Agricultural Science 148, no. 4 (2010): 421–32. http://dx.doi.org/10.1017/s0021859610000110.

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SUMMARYThe aim of the present study was to use data from herds to demonstrate the degree of seasonal influence on litter size at birth in gilts compared to sow parities 2, 3–5 and older (parities ⩾6) in a conventional, open-housing system for commercial pig herds in the northeastern part of Thailand. Data were obtained during a 3-year period from July 2005 to June 2008. The data analysed included observations on 25 835 litters from 8100 sows. Total number of piglets born per litter (TB), number of piglets born alive per litter (BA), proportion of stillborn piglets per litter (SB) and proportio

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7

Hartridge-Lambert, Sidonie K., Heiko Schoder, Remy C. Lim, Jocelyn C. Maragulia, and Carol S. Portlock. "Six Cycles of ABVD and a Negative PET Scan Negates the Need for Radiologic Follow-up in Early Stage, Non-Bulky Hodgkin Lymphoma: MSKCC Retrospective Analysis." Blood 118, no. 21 (2011): 3139. http://dx.doi.org/10.1182/blood.v118.21.3139.3139.

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Abstract Abstract 3139FN2 Introduction: Early stage, non-bulky (nb) classical Hodgkin lymphoma (cHL) patients receive intensive radiologic surveillance after completion of standard therapy despite a statistically low risk of relapse. This study sought to evaluate the relapse risk and value of radiologic surveillance in this subset of patients treated with 6 cycles of ABVD who achieve a PET negative complete remission (CR). Methods: We identified all early-stage, nb cHL patients who were treated with 6 cycles of ABVD at MSKCC from 01/2002 to 12/2008. To be eligible for the study, patients had t

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8

Andrade-Gonzalez, Xavier, Raphael Mwangi, Jithma P. Abeykoon, et al. "Impact of Double Hit Lymphoma and Cell of Origin in the Risk of Central Nervous System Relapse in Patients with Newly Diagnosed Diffuse Large B-Cell Lymphoma." Blood 138, Supplement 1 (2021): 1439. http://dx.doi.org/10.1182/blood-2021-151973.

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Abstract Introduction: Central nervous system (CNS) relapse is an uncommon but devastating complication occurring in about 2-10% of patients with diffuse large B-cell lymphoma (DLBCL). The CNS-IPI is a validated prognostic tool used to identify patients at high risk of CNS relapse. MYC and BCL2/BCL6 rearrangements (double-hit lymphoma- DHL) and non-GCB (NGCB) cell of origin may be at higher risk of CNS relapse. However, the ability of these molecular data to refine CNS-IPI risk prediction has not been assessed. In this study, we aimed to describe the impact of DHL and NGCB cell of origin in th

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9

Warmansyah, Jhoni, Restu Yuningsih, Evi Selva Nirwana, et al. "The Effect of Mathematics Learning Approaches and Self-Regulation to Recognize the Concept of Early Numbers Ability." JPUD - Jurnal Pendidikan Usia Dini 17, no. 1 (2023): 54–81. http://dx.doi.org/10.21009/jpud.171.05.

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The ability to recognize the concept of early numbers in early childhood is very important to develop so that children are ready to take part in learning mathematics at a higher level. This study aims to determine the effect of mathematics learning approaches and self-regulation to recognize the concept of early numbers ability in kindergarten. The study used an experimental method with a treatment design by level 2x2. The sample used was 32 children. Score data, ability to recognize number concepts, analyzed and interpreted. The results showed that: (1) The Realistic Mathematics Education app

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10

Goffin, Kay, Marc van Maris, and Ronald J. Corbee. "Effects of matrix on plasma levels of EPA and DHA in dogs." Journal of Nutritional Science 6 (2017). http://dx.doi.org/10.1017/jns.2017.30.

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AbstractEPA and DHA are often used in veterinary medicine due to their beneficial effects for several medical conditions such as osteoarthritis. EPA and DHA are administered to dogs through different matrices. The aim of the present study was to determine the effects on the plasma levels in dogs caused by various matrices for EPA and DHA administration. In this study, three different n-3 PUFA formulations were used: soft chew tablet (CCx); liquid fish oil (LFO); and enriched kibbles (EK). The formulations were administered single-dose and compared in a randomised, cross-over designed study wit

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11

Jammeh, Momodou L., J. Westley Ohman, Chandu Vemuri, Ahmmad A. Abuirqeba, and Robert W. Thompson. "Anatomically Complete Supraclavicular Reoperation for Recurrent Neurogenic Thoracic Outlet Syndrome: Clinical Characteristics, Operative Findings, and Long-term Outcomes." HAND, January 27, 2021, 155894472098807. http://dx.doi.org/10.1177/1558944720988079.

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Background: The clinical outcomes of reoperations for recurrent neurogenic thoracic outlet syndrome (NTOS) remain undefined. Methods: From 2009 to 2019, 90 patients with recurrent NTOS underwent anatomically complete supraclavicular reoperation after previous operation(s) performed at other institutions using either supraclavicular (Prev-SC = 48), transaxillary (Prev-TA = 31), or multiple/combination (Prev-MC = 11) approaches. Prospectively maintained data were analyzed retrospectively. Results: The mean patient age was 39.9 ± 1.4 years, 72% were female, and the mean interval after previous op

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12

Montenegro, Thiago Scharth, Akash Singh, Christopher Elia, et al. "Independent Predictors of Revision Lumbar Fusion Outcomes and the Impact of Spine Surgeon Variability: Does It Matter Whether the Primary Surgeon Revises?" Neurosurgery, August 14, 2021. http://dx.doi.org/10.1093/neuros/nyab300.

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Abstract BACKGROUND There is a paucity of information regarding treatment strategies and variables affecting outcomes of revision lumbar fusions. OBJECTIVE To evaluate the influence of primary vs different surgeon on functional outcomes of revisions. METHODS All elective lumbar fusion revisions, March 2018 to August 2019, were retrospectively categorized as performed by the same or different surgeon who performed the primary surgery. Oswestry Disability Index (ODI) and clinical variables were collected. Multiple logistic regression identified multivariable-adjusted odds ratio (OR) of independe

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KIEŁKOWICZ, Aleksandra, Piotr PISERA, Filip PACTWA, et al. "Platelet-rich plasma - a revolutionary therapeutic option in multi-disciplinary indications." January 7, 2024. https://doi.org/10.12775/JEHS.2024.51.011.

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<strong>KIEŁKOWICZ, Aleksandra, PISERA, Piotr, PACTWA, Filip, POPIŃSKA, Zuzanna, ŻMUDA, Bartłomiej, ŚLUSARCZYK, Daniel, JAKUBOWSKA, Wiktoria and ŻUBEREK, Michał. Platelet-rich plasma - a revolutionary therapeutic option in multi-disciplinary indications</strong><strong>. Journal of Education, Health and Sport. 2024;51:</strong><strong>140</strong><strong>-</strong><strong>154</strong><strong>. eISSN 2391-8306. </strong><strong><u>https://dx.doi.org/10.12775/JEHS.2024.51.01</u></strong><strong><u>1</u></strong> <strong><u>https://apcz.umk.pl/JEHS/article/view/477</u></strong><strong><u>44</u></

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Raffa, Taylor, Parker Chang, Babak Sarani, and Susan Kartiko. "Surgical Stabilization of Rib Fractures: A Review of the Indications, Technique, and Outcomes." Medical Research Archives 11, no. 11 (2023). http://dx.doi.org/10.18103/mra.v11i11.4694.

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Rib Fractures are a common injury in trauma patients and affect 10% of all injured patients who require admission to the hospital. Currently, there is no consensus on the most efficacious treatment for rib fractures with the debate comparing non-surgical versus surgical management. Medical management of rib fractures often requires admission to the intensive care unit with a focus on pain control to allow good pulmonary hygiene. Pain control involved a multimodal approach with current techniques including epidural anesthesia and paravertebral blocks. Although many patients recover with medical

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15

Dolomatov, S.I., та W. Zukow. "Эпигенетика почек = Kidneys epigenetics". 7 липня 2019. https://doi.org/10.5281/zenodo.3270754.

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<strong>Dolomatov S.I., Zukow W. </strong><strong>Эпигенетика почек</strong><strong> = Kidney</strong><strong>s</strong><strong> epigenetics</strong><strong>. </strong><strong>RSW. Radom,</strong><strong> 144 </strong><strong>p. ISBN </strong><strong>9780359774524</strong><strong>.</strong><strong> DOI </strong><strong>http://dx.doi.org/10.5281/zenodo.3270699</strong><strong> PBN Poland </strong><strong>https://pbn.nauka.gov.pl/sedno-webapp/works/917606</strong>           <strong>Radomska Szkoła Wyższa w Radomiu, Radom, Poland</strong>         &nbsp

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Bowers, Olivia, and Mifrah Hayath. "Cultural Relativity and Acceptance of Embryonic Stem Cell Research." Voices in Bioethics 10 (May 16, 2024). http://dx.doi.org/10.52214/vib.v10i.12685.

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Photo ID 158378414 © Eduard Muzhevskyi | Dreamstime.com ABSTRACT There is a debate about the ethical implications of using human embryos in stem cell research, which can be influenced by cultural, moral, and social values. This paper argues for an adaptable framework to accommodate diverse cultural and religious perspectives. By using an adaptive ethics model, research protections can reflect various populations and foster growth in stem cell research possibilities. INTRODUCTION Stem cell research combines biology, medicine, and technology, promising to alter health care and the understanding

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Kojo, Kosuke, Tomoko Oguri, Takazo Tanaka, et al. "Seminal plasma metallomics: a new horizon for diagnosing and managing male infertility." Revista Internacional de Andrología 23, Published Ahead of Print (2025). https://doi.org/10.22514/j.androl.2025.013.

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The authors, Kosuke Kojo and Tomoko Oguri, contributed equally. This HTML edition is publicly accessible at the following URL:https://academic298uro.github.io/open-archive/2025/seminal-plasma-metallomics-new-horizon/ Abstract Seminal plasma contains a wide range of biomolecules—including inorganic elements—that may significantly influence male reproductive function. Historically, semen analysis has focused on sperm count and motility, while overlooking the diagnostic potential of this acellular fraction. This narrative review synthesizes historical perspectives on seminal plasma me

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