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Статті в журналах з теми "Ex-vivo rat model":
Citak, N., S. Arni, J. Cehn, L. Ceulemans, I. Schmitt-Opitz, and I. Inci. "Subnormothermic Ex Vivo Lung Perfusion Improves Graft Preservation in Rat Ex Vivo Lung Perfusion Model." Journal of Heart and Lung Transplantation 39, no. 4 (April 2020): S354. http://dx.doi.org/10.1016/j.healun.2020.01.416.
Kural, Mehmet H., Guohao Dai, Laura E. Niklason, and Liqiong Gui. "An Ex Vivo Vessel Injury Model to Study Remodeling." Cell Transplantation 27, no. 9 (August 10, 2018): 1375–89. http://dx.doi.org/10.1177/0963689718792201.
Ohsumi, Akihiro, Takashi Kanou, Aadil Ali, Zehong Guan, David M. Hwang, Thomas K. Waddell, Stephen Juvet, Mingyao Liu, Shaf Keshavjee, and Marcelo Cypel. "A method for translational rat ex vivo lung perfusion experimentation." American Journal of Physiology-Lung Cellular and Molecular Physiology 319, no. 1 (July 1, 2020): L61—L70. http://dx.doi.org/10.1152/ajplung.00256.2019.
Abubakar, Adamu Abdul, Sahar Mohammed Ibrahim, Ahmed Khalaf Ali, Kareem Obayes Handool, Mohammad Shuaib Khan, Mohamed Noordin Mustapha, Tengku Azmi Ibrahim, Ubedullah Kaka, and Loqman Mohamad Yusof. "Postnatal ex vivo rat model for longitudinal bone growth investigations." Animal Models and Experimental Medicine 2, no. 1 (February 20, 2019): 34–43. http://dx.doi.org/10.1002/ame2.12051.
Hoff, Catherine M. "Ex vivo and in vivo gene transfer to the peritoneal membrane in a rat model." Nephrology Dialysis Transplantation 16, no. 3 (March 1, 2001): 666–68. http://dx.doi.org/10.1093/ndt/16.3.666.
Sierakowiak, Adam, Anna Mattsson, Marta Gómez-Galán, Teresa Feminía, Lisette Graae, Sahar Nikkhou Aski, Peter Damberg, Mia Lindskog, Stefan Brené, and Elin Åberg. "Hippocampal Morphology in a Rat Model of Depression: The Effects of Physical Activity." Open Neuroimaging Journal 9, no. 1 (January 30, 2015): 1–6. http://dx.doi.org/10.2174/1874440001509010001.
Bouckaert, Charlotte, Emma Christiaen, Jeroen Verhoeven, Benedicte Descamps, Valerie De Meulenaere, Paul Boon, Evelien Carrette, Kristl Vonck, Christian Vanhove, and Robrecht Raedt. "Comparison of In Vivo and Ex Vivo Magnetic Resonance Imaging in a Rat Model for Glioblastoma-Associated Epilepsy." Diagnostics 11, no. 8 (July 21, 2021): 1311. http://dx.doi.org/10.3390/diagnostics11081311.
Ma, Zhe, Sheng-jun Wang, Chuan-fu Li, Xiang-xing Ma, and Tao Gu. "Increased metabolite concentration in migraine rat model by proton MR spectroscopy in vivo and ex vivo." Neurological Sciences 29, no. 5 (October 2008): 337–42. http://dx.doi.org/10.1007/s10072-008-0991-5.
Savolainen-Peltonen, H., L. Petrov, and P. Hayry. "RAT AORTIC ALLOGRAFT EXPLANT ASSAY AS AN EX VIVO MODEL OF ALLOGRAFT ARTERIOSCLEROSIS." Transplantation 78 (July 2004): 623. http://dx.doi.org/10.1097/00007890-200407271-01678.
Liu, Mingyao, Lorraine Tremblay, Stephen D. Cassivi, Xiao-Hui Bai, Eric Mourgeon, Andrew F. Pierre, Arthur S. Slutsky, Martin Post, and Shaf Keshavjee. "Alterations of nitric oxide synthase expression and activity during rat lung transplantation." American Journal of Physiology-Lung Cellular and Molecular Physiology 278, no. 5 (May 1, 2000): L1071—L1081. http://dx.doi.org/10.1152/ajplung.2000.278.5.l1071.
Дисертації з теми "Ex-vivo rat model":
Omasa, Mitsugu. "Glycine ameliorates lung reperfusion injury after cold preservation in an ex vivo rat lung model." Kyoto University, 2004. http://hdl.handle.net/2433/147462.
Papegay, Bérengère. "Identification des mécanismes moléculaires de l'hépatoprotection du foie de rat isolé." Thesis, Lille 2, 2020. http://www.theses.fr/2020LIL2S015.
The protective effect of fasting has been observed in several areas of health. To study it, a rat liver model perfused exvivo was used here. In this model, we did not observe, for an 18h fasting, the protective effect reported for the liverin situ. However, we did emphasize the importance of the energy cost of the protective mechanism in the isolatedliver under experimental stress of ischemia/reperfusion and correlated protection with higher glycogen levels and anenergy load that required an exceeding threshold below which protection fades. The administration of energysubstrates (lactate and alanine) allowed us to confirm the energetic need for protection of the isolated liver. Then,increasing the duration of fasting of the donor rat from 18 to 24 hours proved to be hepatoprotective and, moregenerally, showed that the capacity for energy mobilization and, as such, autophagy contributed to hepatoprotection,the well-known energy cost of autophagy being in line with previous PhD work. Three candidate signaling pathwaysfor the activation of autophagy, involving AMPK, HMGB1 and ADP, were studied. Phosphorylation of AMPK wasincreased in fasted rat liver 24 hours vs. 18 hours. However, the addition of AICAR, an activator of AMPK, althoughincreasing its phosphorylation in isolated fasted rat liver 18h, did not induce protection. HMGB1 accumulation knownto induce autophagy, showed no correlation with markers of hepatic cytolysis (LDH) and autophagy (LC3II/Actin ratio).ADP, in its ADP/(AMP+ADP+ATP) and ADP/(AMP+ATP) ratios, was higher in 24-hour fasted rat livers and was correlatedwith hepatoprotection. ADP induced autophagy by activation of the membrane P2Y13 receptor, a specific inhibitor,MRS2211, was used. Its inclusion in the perfusate blunted the hepatoprotection and activation of autophagyassociated with prolonged fasting, validating the key role of this signaling in hepatoprotection.In conclusion, the Ph.D. allowed a substantial advance in the understanding of the role played by the nutritional statusof the donor on the hepatoprotection of the isolated liver. The identification of the molecular mechanisms ofhepatoprotection (energy mobilization, autophagy) and of its signaling (ADP, P2Y13 receptor) opens up innovativetherapeutic perspectives for liver diseases and new strategies for liver graft preservation. From a cell survivalperspective, autophagy ensures both a function of maintaining the quality of cellular components and an energeticrole. This maintenance of quality protects the cell and costs energy, making it indispensable for this type of protection.In other words, the maintenance preserves from deterioration and this protection has a cost that goes throughsignalling (internal funding decision) which, once identified, can now be requested as desired. Also, external financing(contribution of energy substrates) can be chosen or even added to the previous one
Aguiló, Espases Rafael. "Protección frente al enfriamiento intenso por anticongelantes naturales. Modelo ex-vivo de preservación de pulmón de rata." Doctoral thesis, Universitat de Barcelona, 2000. http://hdl.handle.net/10803/1194.
Trocme, Caryn. "Role des sequences cre et tre dans la regulation de l'expression du gene codant pour la tyrosine hydroxylase de rat ; etudes ex vivo et par transgenese." Paris 11, 1997. http://www.theses.fr/1997PA11T026.
Gozalbes-Bappel, Catherine. "Effets vasculaires de deux diurétiques de l'anse : pirétanide et furosémide. Etudes ex vivo chez le rat spontanément hypertendu et in vitro chez le cobaye." Bordeaux 2, 1997. http://www.theses.fr/1997BOR28532.
Menezes, Arteiro Queiroz. "Estudo de pulmões de ratos reperfundidos em um modelo experimental ex-vivo: comparação entre duas soluções de preservação (Perfadex® e Celsior®)." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5156/tde-09082013-120744/.
INTRODUCTION: Ischemia-reperfusion injury remaisn the leading cause of mortality related to lung transplantation. Its severity is influenced by several factors including lung preservation. OBJECTIVE: To compare two lung preservation solutions, Perfadex® and Celsior® and its ability to preserve ischemic lung tissue. METHODS: Sixty rat lungs were preserved with Perfadex®, Celsior® or saline after a cold ischemic period of 6 or 12 hours and were then reperfused with homologous blood in an ex vivo experimental model for 60 consecutive minutes. At 10-minute intervals during reperfusion of the heart-lung blocks, data were collected for blood gases, hematocrit, mechanical ventilation, hemodynamic and the heart-lung block weight was recorded. At the end of reperfusion, the left lung was weighed and packaged kept at 70oC for 48h to obtain the wet-to-dry weight ratio. Lung tissue samples were processed for histology, electron microscopy and TUNEL. Statistical analysis included a comparison of the solutions and ischemic times, using ANOVA and Kruskal-Wallis. The significance level was set at 5%. RESULTS: The comparison between the compliance of lungs preserved with Celsior® and Perfadex® in ischemic times of 6 and 12 hours was not statistically significant (p=0.161 and p=0.316, respectively). The lungs subjected to 6 hours of ischemia showed higher lung compliance compared to 12 hours (p=0.02 Perfadex®; Celsior® p=0.019; saline p=0.016). The pulmonary artery pressure values were similar between the three solutions in two stages of ischemia and comparing the times of 6 and 12 hours, regardless of the solution. The Relative Oxygenation Capacity showed no significant difference between the three solutions tested, regardless of the ischemic time. The comparison between the two ischemic times showed that oxygenation capacity was significantly worse in lungs preserved with saline for 12 hours (p=0.001). The wet-to-dry weight ratio showed no statistically significant difference between the three solutions in both ischemic times. However, when ischemic times were compared, Perfadex® showed greater wet-to-dry weight ratio in lungs submitted to 12 hours of ischemia (p=0.001). Light microscopy showed that lungs preserved with saline had more edema than the others, regardless of the ischemic time. Assessment of apoptosis by the TUNEL assay showed no statistically significant difference in the comparison between the groups. CONCLUSIONS: The lungs preserved with Celsior® and Perfadex® performed evenly in regards to gas exchange, hemodynamics and ventilatory mechanics. The lungs preserved with Perfadex® for 12 hours were more edematous. Histopathology findings did not differ between the groups
McCormick, Patrick N. "Ex vivo Binding of the Agonist PET Radiotracer [11C]-(+)-PHNO to Dopamine D2/D3 Receptors in Rat Brain: Lack of Correspondence to the D2 Recepor Two-affinity-state Model." Thesis, 2010. http://hdl.handle.net/1807/26296.
Частини книг з теми "Ex-vivo rat model":
Rigo, Federica, Victor Navarro-Tableros, Nicola De Stefano, Alberto Calleri, and Renato Romagnoli. "Ex Vivo Normothermic Hypoxic Rat Liver Perfusion Model: An Experimental Setting for Organ Recondition and Pharmacological Intervention." In Methods in Molecular Biology, 139–50. New York, NY: Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1225-5_10.
Suzuki, Masatoshi, and Clive N. Svendsen. "Ex Vivo Gene Therapy Using Human Mesenchymal Stem Cells to Deliver Growth Factors in the Skeletal Muscle of a Familial ALS Rat Model." In Gene Therapy for Neurological Disorders, 325–36. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3271-9_24.
Watanabe, Makino, and Takao Okada. "Langendorff Perfusion Method as an Ex Vivo Model to Evaluate Heart Function in Rats." In Methods in Molecular Biology, 107–16. New York, NY: Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-8597-5_8.
Sakariassen, Kjell S., Helge E. Roald, and José Aznar Salatti. "Ex Vivo Models for Studying Thrombosis: Special Emphasis on Shear Rate Dependent Blood-Collagen Interactions." In Advances in Cardiovascular Engineering, 151–74. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4757-4421-7_10.
Litt, L., and M. T. Espanol. "Ex Vivo MuEtinuciear NMR Spectroscopy of Perfused, Respiring Rat Brain Slices: Model Studies of Hypoxia, Ischemia, and Excitotoxscit." In Biological NMR Spectroscopy. Oxford University Press, 1997. http://dx.doi.org/10.1093/oso/9780195094688.003.0031.
Тези доповідей конференцій з теми "Ex-vivo rat model":
Seehase, Sophie, Sarah-Philine Köhncke, Heinz-Gerd Hoymann, Armin Braun, and Katherina Sewald. "Effect Of Tiotropium On In Vivo And Ex Vivo Lung Function In A Rat Model Of Bronchoconstriction." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3586.
Chamone, D. A. F., M. Ivany-Silva, C. Cassaro, G. Bellotti, C. Massumoto, and A. Y. Hoshikawa-Fujimura. "GUARANA (Paullinia cupana) INHIBITS AGGREGATION IN WHOLE BLOOD." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644553.
Kumar, A., J. Fareed, W. H. Wehrmacher, D. Hoppensteadt, O. Ulutin, and J. M. Walenga. "ENDOTHELIAL FUNCTION MODULATION AND CONTROL OF VASCULAR AND THROMBOTIC DISORDERS: EXPERIMENTAL RESULTS WITH A POLYDEOXY RIBONUCLEOTIDE AGENT DEFIBROTIDE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643149.
Mizoguchi, S., T. Tsuchiya, M. Ishii, R. Doi, H. Watanabe, G. Hatachi, T. Miyazaki, K. Matsumoto, and T. Nagayasu. "Use of Bioengineered Rat Lungs for Novel Ex Vivo Human Lung Cancer Models." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a5676.
Landry, Thomas G., and Jeremy A. Brown. "B-mode and Doppler imaging of in vivo rat brain and ex vivo human brain with a high frequency endoscopic phased array." In 2019 IEEE International Ultrasonics Symposium (IUS). IEEE, 2019. http://dx.doi.org/10.1109/ultsym.2019.8925902.
Singh, Sundeep, and Roderick Melnik. "Computational Model of Radiofrequency Ablation of Cardiac Tissues Incorporating Thermo-Electro-Mechanical Interactions." In ASME 2020 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/imece2020-23367.
Bommer, Kathleen M., Angela DiBenedetto, and Jens O. M. Karlsson. "High-Speed Imaging of Intra-Embryonic Phase Transformation Events During Rapid Freezing of Zebrafish Embryos." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53953.
Kimmel, Jeremy D., Morgan V. DiLeo, Isabella E. Valenti, Gregory A. Gibson, Simon C. Watkins, and William J. Federspiel. "Dynamics of Cytokine Capture Within Hemoadsorption Beads Used to Treat Sepsis." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-204764.
Banerjee, Nilam Sanjib, Dianne W. Moore, Abhisek Gangrade, Donald J. Buchsbaum, Luise Burt Nabors, Thomas R. Broker, and Louise T. Chow. "Abstract LB250: Development of organoid raft cultures of cervical, breast and glioblastoma tumors as quick economical ex vivo human cancer models for pre-clinical drug evaluation." In Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-lb250.
Borowska, A., D. Lauri, A. Maggi, E. Dejana, G. de Gaetano, and J. Pangrazzi. "IMPAIREMENT OF PRIMARY HAEMOSTASIS BY LMW-HEPARINS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643172.