Добірка наукової літератури з теми "Immunité humorale et cellulaire"
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Статті в журналах з теми "Immunité humorale et cellulaire":
Régent, A., G. Bussone, S. V. Kaveri, and L. Mouthon. "Auto-immunité humorale et cellulaire : de la physiologie à la pathologie." La Revue de Médecine Interne 30, no. 12 (December 2009): H1—H8. http://dx.doi.org/10.1016/s0248-8663(09)73166-2.
Williams, J. C., M. G. Peacock, and R. E. Race. "Immunisation de chiens avec des vaccins contre la fièvre Q: comparaison entre des vaccins de Coxiella burnetii de phase I, phase II et du RCM de phase I." Revue d’élevage et de médecine vétérinaire des pays tropicaux 46, no. 1-2 (January 1, 1993): 87–94. http://dx.doi.org/10.19182/remvt.9404.
Karkouche, Raymond. "Auto-immunité à médiation cellulaire : lupus et connectivités." Annales de Pathologie 38, no. 1 (February 2018): 43–54. http://dx.doi.org/10.1016/j.annpat.2017.10.012.
Larbouret, Christel, Marie-Alix Poul, and Thierry Chardès. "Imiter la réponse immunitaire humorale polyclonale." médecine/sciences 35, no. 12 (December 2019): 1083–91. http://dx.doi.org/10.1051/medsci/2019216.
Wechsler, Janine. "Immunité à médiation humorale : vascularites cutanées et maladies bulleuses auto-immunes." Annales de Pathologie 38, no. 1 (February 2018): 31–42. http://dx.doi.org/10.1016/j.annpat.2017.11.003.
Frange, P., M. A. Frey, and G. Deschênes. "Immunité cellulaire et traitement immunosuppresseur du syndrome néphrotique idiopathique corticosensible." Archives de Pédiatrie 12, no. 3 (March 2005): 305–15. http://dx.doi.org/10.1016/j.arcped.2004.12.015.
Lafaix, Ch, Ch Blondeau, S. Djebbour-Levy, V. Naslet-Bonnotte, F. Faibis, and J. P. Emond. "Immunité naturelle humorale vis-à-vis des méningocoques A et C en France." Médecine et Maladies Infectieuses 25 (April 1995): 636–41. http://dx.doi.org/10.1016/s0399-077x(05)80860-1.
Kostine, Marie, Aurélien Marabelle, Thierry Schaeverbeke, and Maria Kfoury. "Les limites des inhibiteurs de points de contrôle immunitaire et la gestion de leur toxicité." médecine/sciences 35, no. 12 (December 2019): 949–56. http://dx.doi.org/10.1051/medsci/2019191.
Cavaillon, Jean-Marc, Philippe Sansonetti, and Michel Goldman. "Jules Bordet, un homme de conviction." médecine/sciences 36, no. 8-9 (August 2020): 803–9. http://dx.doi.org/10.1051/medsci/2020135.
Espi, M., X. Charmetant, T. Barba, L. Koppe, C. Pelletier, E. Kalbacher, E. Chalencon, D. Fouque, L. Juillard, and O. Thaunat. "Défaut de réponse humorale et cellulaire à la vaccination anti-SARS-CoV2 à ARNm chez les patients hémodialysés naïfs." Néphrologie & Thérapeutique 17, no. 5 (September 2021): 361. http://dx.doi.org/10.1016/j.nephro.2021.07.029.
Дисертації з теми "Immunité humorale et cellulaire":
Rembert, Audrey. "Les vaccins antivarioliques : pathogénicité-innocuité, immunogénicité humorale et cellulaire, protection." Aix-Marseille 2, 2006. http://www.theses.fr/2006AIX20707.
Smallpox, eradicated in 1980, was one of the most dreaded infectious diseases. The threat of re-emerging variola virus induced the evaluation of new smallpox vaccines. The aim of our study was to determine immune factors induced in natural protection against orthopoxviruses and to assess new smallpox vaccines. The characterisation of the mice/cowpoxvirus rodent-like model had put in evidence the important role of all the component of the specific immune system in natural protection of mice. A second generation vaccine (2G) and tree non replicative vaccinia virus strains (3G) was evaluated in our model. The 2G smallpox vaccine showed similar vaccine efficacy than the traditional vaccine. Among the different 3G vaccines assessed, the MVA strain was the only vaccine candidate inducing a similar long-term protection than the traditional vaccine but only after a vaccine boost. However, the long-term induced MVA immunogenicity was inferior to this induced by the traditional smallpox vaccine
Wendling, Daniel. "Aspects immunologiques et systemiques des spondylarthropathies." Besançon, 1991. http://www.theses.fr/1991BESA3703.
Reidel, Ivana. "Análisis de nuevos vehículos y adyuvantes para inmunización con antígenos de Staphylococcus aureus utilizando diferentes modelos experimentales." Thesis, Poitiers, 2020. http://www.theses.fr/2020POIT1803.
Staphylococcus aureus infections represent a major concern for human health and veterinary medicine. The excessive use of antibiotics to treat these infections has led to emergent multi-resistant strains of bacteria and encourages us to develop alternative methods for prevention such as vaccination. To date, there are no vaccines approved for use in humans and only two vaccines are used in the control of bovine mastitis, with a low efficacy. Therefore, new tools are needed to prevent infections caused by S. aureus.The objective of this thesis work is test new vaccine liposomal formulations composed of antigen from S.aureus and different immunostimulating agents including oligodesoxynucleotides (ODN)-CpG, aluminum hydroxide (Al(OH)3), gemini-type proteolipids (AG2-C16) or modified oligosaccharides (Mannan-derived molecules, OPM). The adjuvant capacities of these molecules have been tested in different animal models. In the bovine model, immunizations of calves, heifers and pregnant cows show the efficacy of liposomal formulations composed of S. aureus antigens associated with ODN-CpG, eliciting a strong humoral immune response by the production of specific IgG1 and IgG2 antibodies, able to inhibit S. aureus toxins. In the murine model, intradermal injection of vaccine formulations revealed the efficacy of the adjuvants ODN-CpG, AG2-C16 and OPM in the induction of a robust humoral response (production of specific antibodies) and the development of a cellular response involving IFN-γ-secreting T CD8+ lymphocytes which play a crucial role in the defense against intracellular bacteria. Finally, in order to study the potential of liposomal vaccines to penetrate the skin, considered as an immunization site of interest, in vitro experiments realized on reconstituted mouse epidermis have shown that the proteolipid adjuvant AG2-C16 associated with liposomes promotes their transcutaneous migration, allowing their use for topical administration. Other experiments were carried out on mouse keratinocyte and fibroblast cultures demonstrating the capacity of the oligosaccharide adjuvant OPM to stimulate fibroblast to produce proinflammatory chemokines and cytokines, leading to the development of a stronger immune response toward the vaccine.Together, the results presented in this thesis demonstrate that cationic liposomes constitute a versatile vectorization system, which allows the selection of the proper immunostimulants, depending on the needed immune response characteristics
Meissonnier, Guylaine. "Effets toxiques de l'aflatoxine b1 et de la toxine t-2 sur les systèmes de défenses métaboliques et immunitaires chez le porc, évaluation des effets protecteurs de glucomannanes." Toulouse 3, 2007. http://www.theses.fr/2007TOU30153.
Aflatoxin B1 (AFB1) and T-2 toxin are mycotoxins, secondary metabolites from fungi that sporadically contaminate food and feed, particularly cereals. The mains objectives of our work were to determine in pigs, a target species and highly sensitive to mycotoxin, the toxic effects of AFB1 and T-2 toxin on two defence systems, liver drug-metabolizing enzymes activities et the immune system. We also evaluate in vivo the protective effect of a potent mycotoxin binder. In pigs, AFB1 exposure for the doses investigated did not induce major clinical sign of intoxication. But, we observed lesions in liver tissue, a specific impairment of liver drug-metabolizing enzymes activities (monooxygenase cytochrome P450 dependant) and during immunization we showed a reduced cellular-mediated immune response specific for the vaccine antigen. T-2 toxin exposure did not induce any clinical sign of intoxication, or any tissue lesion in pigs. We observed a specific impairment of liver drug-metabolizing enzymes activities in liver, and during immunization T-2 toxin reduced the production of antibodies specific for the antigen. The addition of glucomannans in feed reduced the toxic effects of both mycotoxins. .
Gougerot-Pocidalo, Marie-Anne. "Processus oxydants et reponses immunitaires : mecanismes biochimiques et cellulaires." Paris 7, 1988. http://www.theses.fr/1988PA077063.
Freyburger, Ludovic. "Etude de la réponse immunitaire cellulaire systémique et humorale muqueuse suite à la vaccination par la sous-unité B de la toxine de Shigella Dysenteriae comme vecteur d'antigène." Paris 5, 2007. http://www.theses.fr/2007PA05T028.
The Shiga toxin subunit B (STxB) is a vaccinal vector targeting dendritic cells. CD4+ and CD8+ T cells responses as well as antibody production were observed after vaccination of mice with chimeric proteins composed of STxB coupled with different antigens. STxB doesn't favour maturation of dendritic cells, thus we assessed the STxB efficiency as vector in combination with different adjuvants. STxB coupled with different antigens and mixed with aGalCer, a glycolipide activating NKT cells, resulted in an increase CD8+ T cells frequency and it also allowed the dramaticaly reduction of antigen doses. This vaccine also permitted to break tolerance to self-antigens and to protect against the development of viral infection. In addition, we have showed that the route of immunization had an influence on the type of immune response (mucosal humoral response jind cellular^ systemic response) observed after the use of STxB
Rammal, Hassan. "L'anxiété trait et son lien avec l'expression des sous-unités des récepteurs (GABAA, 5-HT1A, µ-opioïdes et x1-adrénérgiques) et des marqueurs du stress oxydatif au niveau du SNC (neurones et cellules gliales) et au niveau périphérique (immunité cellulaire et humorale) : évaluation des effets de substances naturelles à potentiel cytoprotecteur." Thesis, Metz, 2008. http://www.theses.fr/2008METZ018S/document.
In this study, genes expression from four central receptors (GABAA, 5-HT1A, m-opioïdes and a1-adrenergic) involved in the modulation of anxiety was assessed. The impact of anxiety on the cellular and humoral immunity and on the oxidative status at the SNC (neurons and glial cells) and peripheral (lymphocytes, granulocytes and monocytes) level was highlighted. At the same time, the effect of anxiety coupled with an anxiogenic restraint stress, on the cellular and humoral immunity was also evaluated. Indeed, the high level of anxiety induced firstly, a significant depressive effect on cellular (total lymphocytes, TCD4+ and TCD8+) and humoral (IgA and IgE) immunity, and secondly, a significant increase of the level of intracellular reactive oxygen species (ROS) of neurons and glial cells in the cerebral cortex, the cerebellum and the hippocampus and in the peripheral blood granulocytes, monocytes and lymphocytes. In the same way, the anxiety coupled to acute and chronic restraint stress provoked, a depression of some parameters of cellular (total lymphocytes, TCD4+, TCD8+ and NK) and humoral (IgA, E and G) immunity, and a stimulation of others (granulocytes and monocytes). These works thus made it possible to validate scientifically the anxiogenic character of the model of restraint stress, to establish in a valid and reproducible way the bond and the correlation between the high level of anxiety in animals and their oxidative status inductive of a cytotoxicity as well as the role of the expression of coding genes of 4 receptors in the expression of this high anxiety and of a significant oxidative status at the level of the peripheral cells of the immune system and the neurons and glial cells at the central level
Schmitt, Christian. "Etude de clones de lymphocytes t humains specifiques de l'anatoxine tetanique." Paris 7, 1987. http://www.theses.fr/1987PA077003.
Buob, David. "Dysfonction du transplant rénal et immunité humorale : aspects anatomo-pathologiques et approche immunoprotéomique." Thesis, Lille 2, 2011. http://www.theses.fr/2011LIL2S042.
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Piriou-Guzylack, Laurence. "Contribution à l'étude des réponses immunitaires cellulaires du porc, par de nouveaux outils méthologiques, dans un modèle d'infection par le virus de la peste porcine classique." Rennes 1, 2002. http://www.theses.fr/2002REN10028.
Книги з теми "Immunité humorale et cellulaire":
Gregory, Bock, and Goode Jamie, eds. The molecular basis of cellular defence mechanisms. Chichester: Wiley, 1997.
Symposium, CIBA Foundation. The Molecular Basis of Cellular Defence Mechanisms - Symposium No. 204. John Wiley & Sons, 1997.