Zeitschriftenartikel: „711.461 1“

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Sakata, Yu, Takeo Minezaki, Yuzuru Yoshii, Yukiyasu Kobayashi, Shintaro Koshida, Tsutomu Aoki, Keigo Enya et al. „LONG-TERM OPTICAL CONTINUUM COLOR VARIABILITY OF NEARBY ACTIVE GALACTIC NUCLEI“. Astrophysical Journal 711, Nr. 1 (11.02.2010): 461–83. http://dx.doi.org/10.1088/0004-637x/711/1/461.

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Banerdt, Justin K., Kondwelani Mateyo, Li Wang, Christopher J. Lindsell, Elisabeth D. Riviello, Deanna Saylor, Douglas C. Heimburger und E. Wesley Ely. „Delirium as a predictor of mortality and disability among hospitalized patients in Zambia“. PLOS ONE 16, Nr. 2 (11.02.2021): e0246330. http://dx.doi.org/10.1371/journal.pone.0246330.

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Objective To study the epidemiology and outcomes of delirium among hospitalized patients in Zambia. Methods We conducted a prospective cohort study at the University Teaching Hospital in Lusaka, Zambia, from October 2017 to April 2018. The primary exposure was delirium duration over the initial 3 days of hospitalization, assessed daily using the Brief Confusion Assessment Method. The primary outcome was 6-month mortality. Secondary outcomes included 6-month disability, evaluated using the World Health Organization Disability Assessment Schedule 2.0. Findings 711 adults were included (median age, 39 years; 461 men; 459 medical, 252 surgical; 323 with HIV). Delirium prevalence was 48.5% (95% CI, 44.8%-52.3%). 6-month mortality was higher for delirious participants (44.6% [39.3%-50.1%]) versus non-delirious participants (20.0% [15.4%-25.2%]; P < .001). After adjusting for covariates, delirium duration independently predicted 6-month mortality and disability with a significant dose-response association between number of days with delirium and odds of worse clinical outcome. Compared to no delirium, presence of 1, 2 or 3 days of delirium resulted in odds ratios for 6-month mortality of 1.43 (95% CI, 0.73–2.80), 2.20 (1.07–4.51), and 3.92 (2.24–6.87), respectively (P < .001). Odds of 6-month disability were 1.20 (0.70–2.05), 1.73 (0.95–3.17), and 2.80 (1.78–4.43), respectively (P < .001). Conclusion Among hospitalized medical and surgical patients in Zambia, delirium prevalence was high and delirium duration independently predicted mortality and disability at 6 months. This work lays the foundation for prevention, detection, and management of delirium in low-income countries. Long-term follow up of outcomes of critical illness in resource-limited settings appears feasible using the WHO Disability Assessment Schedule.

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Lara, Rogeria Inês Rosa, Daniell Rodrigo Rodrigues Fernandes, Danielle Roberta Versuti, Maria Flora de Almeida Tango und Nelson Wanderley Perioto. „Sampling and Diversity of Hymenoptera (Insecta) in an Orange Orchard/Brazilian Savannah Fragment Interface“. EntomoBrasilis 8, Nr. 1 (18.04.2015): 51–57. http://dx.doi.org/10.12741/ebrasilis.v8i1.483.

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The aim of this work was to assess the diversity of Hymenoptera in an orange orchard / Brazilian savannah fragment interface in Descalvado, State of São Paulo, Brazil, using Moericke, Malaise and pitfall traps. The sampling was carried out from February to June 2006, when 5,148 specimens of Hymenoptera, from 12 superfamilies and 36 families, were caught: Chalcidoidea (1,885 specimens; 36.6% out of the total; 14 families), Ichneumonoidea (715; 13.9%; 2), Vespoidea (554; 10.8%; 5), Apoidea (444; 8.6%; 2), Diaprioidea (430; 8.4%; 2), Chrysidoidea (366; 7.1%; 3), Platygastroidea (340; 6.6%; 2), Ceraphronoidea (211; 4.1%; 2), Cynipoidea (107; 2.1%; 1), Evanioidea (83; 1.6%; 1), Tenthredinoidea (7; 0.1%; 1) and Trigonaloidea (6; 0.1%; 1). The Moericke and Malaise traps installed in the Brazilian savannah fragment were responsible for capturing the highest number of Hymenoptera (2,158 specimens; 41.9% out of the total collected and 1,739; 33.8%, respectively), followed by the Moericke traps placed in the orange orchard (1,123; 21.8%) and by the pitfall traps (128; 2.5%). The results indicate that the diversity of families of Hymenoptera in the Brazilian savannah fragment is greater than in the culture of citrus and expresses the greatest diversity of hosts existing in that environment. The study made clear that the combined use of different kinds of traps allows the capture of a large diversity of Hymenoptera. Amostragem e Diversidade de Hymenoptera (Insecta) em uma Interface Cultura de Citros/Fragmento de Cerrado Resumo. O objetivo deste estudo foi avaliar a diversidade de himenópteros de uma interface cultura de citros/fragmento de Cerrado em Descalvado, SP, Brasil, através do uso de armadilhas de Moericke, de Malaise e de pitfall. As amostragens ocorreram entre fevereiro e junho de 2006, quando foram obtidos 5.148 exemplares de himenópteros pertencentes a 12 superfamílias e 36 famílias: Chalcidoidea (1.885 exemplares; 36,6% do total; 14 famílias), Ichneumonoidea (715; 13,9%; 2), Vespoidea (554; 10,8%; 5), Apoidea (444; 8,6%; 2), Diaprioidea (430; 8,4%; 2), Chrysidoidea (366; 7,1%; 3), Platygastroidea (340; 6,6%; 2), Ceraphronoidea (211; 4,1%; 2), Cynipoidea (107; 2,1%; 1), Evanioidea (83; 1,6%; 1), Tenthredinoidea (7; 0,1%; 1) e Trigonaloidea (6; 0,1%; 1). As armadilhas de Moericke e de Malaise instaladas no fragmento de Cerrado capturaram o maior número de exemplares de himenópteros (2.158 exemplares; 41,9% do total coletado e 1.739; 33,8%, respectivamente), seguidas pelas de Moericke instaladas na cultura de citros (1.123; 21,8%) e pitfall (128; 2,5%). Os resultados obtidos indicam que a diversidade de famílias de himenópteros no fragmento de Cerrado é maior do que na cultura de citros e expressa a maior diversidade de hospedeiros existente naquele ambiente. O uso combinado de diferentes tipos de armadilhas possibilitou a captura de maior diversidade de grupos de himenópteros.

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Wang, Hong, Run He Shi und Pu Dong Liu. „Theoretical Simulation and Feasibility Analysis of the Estimation of Crop Leaf Chlorophyll Using Narrow Band NDVI“. Applied Mechanics and Materials 651-653 (September 2014): 317–22. http://dx.doi.org/10.4028/www.scientific.net/amm.651-653.317.

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Remote sensing technology is one of the best methods for the large-scale monitoring of chlorophyll in crops. This study analyzes the feasibility of estimating the contents of chlorophyll by means of narrow band normalized difference vegetation indices (NDVInb). The reflectance of the two bands forming the NDVInbis from simulations run on the PROSPECT model. A traversal of possible combinations of NDVInbare examined from 400 nm to 800 nm. Our results indicate that, at the leaf level, estimation of chlorophyll content can be identified in NDVInb. Ranges for these bands include: 1) 720-735 nm combined with 400-428 nm; 2) 550-615 nm, 692-701 nm or 707-715 nm combined with 400-432 nm or 462-496 nm; 3) 562-589 nm, 616-662 nm or 729-737 nm combined with 434-454 nm; and 4) 664-687 nm combined with 550-615 nm or 692-701 nm.

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Underwood, Mark, Rimgaile Urbaityte, Ruolan Wang, Joe Horton, James Oyee, Brian Wynne, Dainielle Fox, Bryn Jones, Choy Man und Jörg Sievers. „Dolutegravir + Lamivudine vs. Dolutegravir + Tenofovir Disoproxil Fumarate/Emtricitabine: Very-Low-Level HIV-1 Replication through 144 Weeks in the GEMINI-1 and GEMINI-2 Studies“. Viruses 16, Nr. 3 (06.03.2024): 405. http://dx.doi.org/10.3390/v16030405.

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In GEMINI-1/-2, dolutegravir + lamivudine was non-inferior to dolutegravir + tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) in achieving viral suppression (viral load [VL] < 50 copies/mL) in treatment-naive adults. Abbott’s RealTime HIV-1 assay provides quantitative VL (40–10,000,000 copies/mL) and qualitative target detected or target not detected (TND) for VL < 40 copies/mL. This post hoc analysis assessed very-low-level viremia and “blips” through Week 144. Proportions with VL < 40 copies/mL and TND are presented overall and by baseline VL and CD4+ cell count. “Blips” (single VL ≥ 50 to <200 copies/mL with adjacent values < 50 copies/mL) were assessed from Day 1 after VL suppression and from Weeks 48 through to 144. Proportions with TND increased through Week 48 and were similar between groups at all visits (Week 144: dolutegravir + lamivudine, 451/716 [63%]; dolutegravir + TDF/FTC, 465/717 [65%]). By observed analysis, TND rates were similar between groups across baseline subgroups. Through Week 144, proportions with ≥1 “blip” were generally comparable for dolutegravir + lamivudine vs. dolutegravir + TDF/FTC from Day 1 (15% vs. 20%) and from Week 48 (7% vs. 11%). Through 144 weeks, the proportions with TND or “blips” were similar between dolutegravir + lamivudine and the three-drug comparator, reinforcing the efficacy and durability of dolutegravir + lamivudine.

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Dunlop, Hayley, Evelyn Fitzpatrick, Kevin Kurti, Stephanie Deeb, Erin F. Gillespie, Laura Dover, Divya Yerramilli, Scarlett Lin Gomez, Fumiko Chino und C. Jillian Tsai. „Participation of Patients From Racial and Ethnic Minority Groups in Phase 1 Early Cancer Drug Development Trials in the US, 2000-2018“. JAMA Network Open 5, Nr. 11 (03.11.2022): e2239884. http://dx.doi.org/10.1001/jamanetworkopen.2022.39884.

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ImportanceDespite federal initiatives encouraging the enrollment of individuals from racial and ethnic minority groups in US clinical trials, no studies to date have specifically examined demographic disparities among participants in phase 1 drug development trials for patients with metastatic cancer.ObjectiveTo assess trends in the enrollment of patients from racial and ethnic minority groups in US phase 1 therapeutic drug trials for metastatic cancer from 2000 to 2018.Design, Setting, and ParticipantsIn this cross-sectional study, ClinicalTrials.gov was queried in July 2021 to identify completed phase 1 drug trials for metastatic cancer in the US from January 1, 2000, to December 31, 2018, with published results, yielding 221 phase 1 trials with 8309 participants aged 18 years or older with metastatic solid tumors. Proportions of each racial and ethnic group of trial participants were compared with that from the North American Association of Central Cancer Registries’ Cancer in North America (CiNA) database. Statistical analysis was performed from July 12, 2021, to March 15, 2022.Main Outcomes and MeasuresFor each racial and ethnic group, the difference between trial and CiNA proportions was examined using a 2-sample test for equality of proportions with continuity correction.ResultsThe 8309 phase 1 trial participants (4198 men [50.5%]; median age, 59 years) included 23 American Indian or Alaska Native participants (0.3%), 371 Asian or Pacific Islander participants (4.5%), 514 Black participants (6.2%), 401 of 5076 Hispanic or Latinx participants (7.9%), and 7154 White participants (86.1%). Industry funded 165 of the 221 trials (74.7%). White patients were overrepresented overall compared with the corresponding CiNA cohort (7154 of 8309 [86.1%] vs 4 113 096 of 4 891 486 [84.1%]; difference, 2.0 percentage points; P &lt; .001). There was an increase in overrepresentation of White patients from 2000 to 2011 (trials, 2780 of 3245 [85.7%]; CiNA, 2 378 019 of 2 800 711 [84.9%]; difference, 0.8 percentage points; P = .23) to 2012-2018 (trials, 4374 of 5063 [86.4%]; CiNA, 1 735 077 of 2 090 775 [82.9%]; difference, 3.5 percentage points; P &lt; .001) and corresponding worsening representation of American Indian or Alaska Native patients (2000-2011: trials, 10 of 3245 [0.3%]; CiNA, 10 905 of 2 800 711 [0.4%]; difference, −0.08 percentage points; 2012-2018: trials, 13 of 5063 [0.3%]; CiNA, 9484 of 2 090 775 [0.5%]; difference, −0.20 percentage points), Asian or Pacific Islander patients (2000-2011: trials, 121 of 3245 [3.7%]; CiNA, 75 033 of 2 800 711 [2.7%]; difference, 1.1 percentage points; 2012-2018: trials, 151 of 5063 [3.0%]; CiNA 70 535 of 2 090 775 [3.4%]; difference, −0.75 percentage points), Black patients (2000-2011: trials, 244 of 3245 [7.5%]; CiNA, 322 701 of 2 800 711 [11.5%]; difference, −4.0 percentage points; 2012-2018: trials, 270 of 5063 [5.3%]; CiNA, 255 625 of 2 090 775 [12.2%]; difference, −6.9 percentage points), and Hispanic or Latinx patients (2000-2011: trials, 161 of 1792 [9.0%]; CiNA, 169 297 of 2 800 711 [6.0%]; difference, 3.0 percentage points; 2012-2018: trials, 240 of 3295 [7.3%]; CiNA, 156 118 of 2 090 775 [7.5%]; difference, −0.2 percentage points). Similar disparities were observed when comparing industry-funded and academic center–sponsored trials.Conclusions and RelevanceIn this cross-sectional study of participants in phase 1 clinical trials of drugs for metastatic cancer, worsening disparities were observed over time in the accrual of patients from racial and ethnic minority groups. These findings may represent widening inequalities in access to trial sites and worsening systemic biases. More efforts are needed to diversify phase 1 cancer drug trials to improve equity in access to new treatments and to ensure that safety and efficacy findings from early drug trials are generalizable across populations.

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Hoffman, Thijs W., Coline H. M. van Moorsel, Joanne J. van der Vis, Douwe H. Biesma und Jan C. Grutters. „No effect of danazol treatment in patients with advanced idiopathic pulmonary fibrosis“. ERJ Open Research 9, Nr. 5 (September 2023): 00131–2023. http://dx.doi.org/10.1183/23120541.00131-2023.

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BackgroundTelomere dysfunction can underly the development of idiopathic pulmonary fibrosis (IPF), and recent work suggests that patients with telomere syndromes might benefit from treatment with androgens, such as danazol.MethodsThis was a prospective observational cohort study. 50 patients with IPF received off-label treatment with danazol after they showed progressive disease under treatment with pirfenidone or nintedanib. The primary outcome was the difference in yearly decline in forced vital capacity (FVC) prior to (pre) and after (post) start of treatment with danazol.ResultsThere was no significant difference in FVC-decline between 1 year pre and 1 year post start of danazol treatment (mean decline pre 395 mL (95% confidence interval (CI) 290–500) compared to post 461 mL (95% CI 259–712); p=0.46; paired t-test). 11 patients (22%) were still on danazol after 1 year, and 39 patients had stopped danazol, mainly because of side-effects (56%) or death (33%). In patients who were still using danazol after 1 year, FVC-decline significantly slowed down under danazol treatment (mean pre 512 mL (95% CI 308–716)versuspost 198 mL (95% CI 16–380); p=0.04). Median survival post danazol was 14.9 months (95% CI 11.0–18.8).ConclusionDanazol as a treatment of last resort in patients with IPF did not lead to slowing of lung function decline and was associated with significant side-effects. It remains to be determined if earlier treatment or treatment of specific patient subgroups is beneficial.

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Ohno, Tomoya, Chihiro Hasegawa, Susumu Nakade, Junsaku Kitagawa, Naoki Honda und Mikio Ogawa. „The prediction of human response to ONO-4641, a sphingosine 1-phosphate receptor modulator, from preclinical data based on pharmacokinetic-pharmacodynamic modeling“. Biopharmaceutics & Drug Disposition 31, Nr. 7 (08.07.2010): 396–406. http://dx.doi.org/10.1002/bdd.719.

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Nguyễn, Minh An, Trung Kiên Ngô und Hoàng Thảo Bùi. „ĐÁNH GIÁ KẾT QUẢ PHẪU THUẬT CẮT TUYẾN TIỀN LIỆT NỘI SOI QUA NIỆU ĐẠO ĐIỀU TRỊ BỆNH TĂNG SẢN LÀNH TÍNH TUYẾN TIỀN LIỆT TẠI BỆNH VIỆN ĐA KHOA XANH PÔN“. VietNam Military Medical Unisversity 48, Nr. 1 (30.01.2023): 88–97. http://dx.doi.org/10.56535/jmpm.v48i1.237.

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Mục tiêu: Đánh giá kết quả xa sau phẫu thuật cắt u phì đại lành tình tuyến tiền liệt (UPĐLTTTL) nội soi tại Bệnh viện Đa khoa Xanh Pôn. Đối tượng và phương pháp: Nghiên cứu mô tả cắt ngang trên 98 bệnh nhân (BN) tuổi trung bình 75,5 ± 3,62, cao nhất 95 tuổi, thấp nhất 55 tuổi. Bảng điểm ISPP trước phẫu thuật: 27,3 ± 2,8; Bảng điểm chất lượng cuộc sống (CLCS) trước phẫu thuật: 5,2 ± 0,7; Chỉ số IIEF trước phẫu thuật: 17,8 ± 5,8; Kết quả: Biến chứng sau phẫu thuật: Hẹp niệu đạo 3,1%; đái rỉ tạm thời 3,1%; xuất tinh ngược dòng 4,1%; Điểm IPSS trung bình sau mổ 1 tháng, 6 tháng và 12 tháng lần lượt là 7,6 ± 3,3; 5,1 ± 2,1 và 4,6 ± 1,8; Điểm CLCS trung bình sau mổ 1 tháng, 6 tháng và 12 tháng lần lượt là: 1,4 ± 0,7; 0,88 ± 0,5 và 0,8 ± 0,4; Chỉ số IIEF trung bình sau mổ 1 tháng, 6 tháng và 12 tháng lần lượt là 12,18 ± 5,8; 12,51 ± 7,11 và 12,9 ± 7,1. Kết luận: Phẫu thuật nội soi điều trị UPĐLTTTL là phương pháp an toàn, hiệu quả, cải thiện CLCS của BN.

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Storandt, Michael H., Urshila Durani, Daniela Stan, Nicole Larson, Charles Loprinzi, Fergus Couch, Janet E. Olson, Nandita Khera und Kathryn J. Ruddy. „Abstract 1012: Financial hardship in breast cancer survivors“. Cancer Research 82, Nr. 12_Supplement (15.06.2022): 1012. http://dx.doi.org/10.1158/1538-7445.am2022-1012.

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Abstract Background: Medical financial hardship, encompassing material, behavioral, and psychologic domains, is becoming an increasingly common consequence of illness in cancer patients. Identifying at-risk patients is the first step to develop proactive approaches to mitigate this problem. To try and address this need, Mayo Clinic Breast Disease Registry (MCBDR) is prospectively collecting data about financial concerns in addition to the usual sociodemographic and clinical information. Methods: We used data from Mayo Clinic Breast Disease Registry, a prospective cohort of consenting patients seen at Mayo Clinic Rochester within one year of initial breast cancer diagnosis. Participants completed baseline and annual follow-up surveys rating their financial concerns on a linear analogue scale from 0 (“none”) to 10 (“constant concerns”). We compared patient-reported financial concern at baseline to that on each patient’s most recent survey, with worsening concerns defined as a 1+-point increase. Logistic regression evaluated for predictors of worsening financial concerns. Results: 1,957 participants responded to financial concern questions on a baseline and at least one follow-up survey between 2015 and 2020. Mean age was 58.5 years (SD 12.5), and mean time between diagnosis and the most recent follow-up was 25.6 months (SD 16.2). 357 (18.2%) reported worsening financial concerns. Only lower baseline financial status was associated with a greater likelihood of worsening financial concerns (see Table). Conclusions: More than one in seven breast cancer survivors develop worsening financial concerns within 5-years of diagnosis, and those with less financial security at baseline appear to be most vulnerable. Funding: Breast Cancer Research Foundation (CLL) and NR015259 (KJR). Patient and tumor characteristics, compared by whether financial status worsened over time Full Cohort (n=1957) Worsening, ≥ 1-point change (n=357) Stable/Improved (n=1600) p value Full Cohort (n=1957) Worsening, ≥ 1-point change (n=357) Stable/Improved (n=1600) p value Age at diagnosis II or III 502 (25.7%) 98 (27.5%) 404 (25.3%) 0.239 ≤ 50 546 (27.9%) 105 (29.4%) 441 (27.6%) IV 67 (3.4%) 17 (4.8%) 50 (3.1%) 0.086 51-64 757 (38.7%) 136 (38.1%) 621 (38.8%) 0.562 Unknown 351 (17.9%) 65 (18.2%) 286 (17.9%) 0.536 ≥65 654 (33.4%) 116 (32.5%) 538 (33.6%) 0.506 ER and/or PR positive Race No/Unknown 482 (24.6%) 92 (25.8%) 390 (24.4%) White 1863 (95.2%) 337 (94.4%) 1526 (95.4%) Yes 1475 (75.4%) 265 (74.2%) 1210 (75.6%) 0.580 Non-white 24 (1.2%) 5 (1.4%) 19 (1.2%) 0.729 Her2 positive Other/Unknown/Choose not to respond 70 (3.6%) 15 (4.2%) 55 (3.4%) 0.478 No/Unknown 1746 (89.2%) 314 (88.0%) 1432 (89.5%) Educational status Yes 176 (9.0%) 37 (10.4%) 139 (8.7%) 0.321 Less than bachelor’s degree 880 (45.0%) 168 (47.1%) 712 (44.5%) Borderline 35 (1.8%) 6 (1.7%) 29 (1.8%) 0.898 Bachelor's degree or higher 1065 (54.4%) 187 (52.4%) 878 (54.9%) 0.384 Radiation Unknown 12 (0.6%) 2 (0.6%) 10 (0.6%) 0.832 No/Unknown 781 (39.9%) 140 (39.2%) 641 (40.1%) Financial status near time of diagnosis Yes 1176 (60.1%) 217 (60.8%) 959 (59.9%) 0.768 Pay bills, money for special things 1412 (72.2%) 244 (68.3%) 1168 (73.0%) Chemotherapy/targeted therapy Pay bills, no money for special things 367 (18.8%) 80 (22.4%) 287 (17.9%) 0.046 No/Unknown 1264 (64.6%) 221 (61.9%) 1043 (65.2%) Pay bills by making cuts 102 (5.2%) 19 (5.3%) 83 (5.2%) 0.729 Yes 693 (35.4%) 136 (38.1%) 557 (34.8%) 0.241 Unable to pay bills 56 (2.9%) 10 (2.8%) 46 (2.9%) 0.911 Hormone/endocrine therapy Unknown 20 (1.0%) 4 (1.1%) 16 (1.0%) 0.750 No/Unknown 710 (36.3%) 141 (39.5%) 569 (35.6%) Employment status at time of diagnosis Yes 1247 (63.7%) 216 (60.5%) 1031 (64.4%) 0.163 Employed full-time 462 (23.6%) 83 (23.2%) 379 (23.7%) Surgery type Employed part-time/unemployed/retired 525 (26.8%) 92 (25.8%) 433 (27.1%) 0.856 Lumpectomy 846 (43.2%) 145 (40.6%) 701 (43.8%) Not available 970 (49.6%) 182 (51.0%) 788 (49.3%) 0.716 Mastectomy 903 (46.1%) 165 (46.2%) 738 (46.1%) 0.535 Stage at time of diagnosis None/Unknown 208 (10.6%) 47 (13.2%) 161 (10.1%) 0.069 0 or I 1037 (53.0%) 177 (49.6%) 860 (53.8%) Citation Format: Michael H. Storandt, Urshila Durani, Daniela Stan, Nicole Larson, Charles Loprinzi, Fergus Couch, Janet E. Olson, Nandita Khera, Kathryn J. Ruddy. Financial hardship in breast cancer survivors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 1012.

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Bapokutty, Omar, Zainuddin Sajuri, Junaidi Syarif und A. R. Said. „Fracture Behavior of Inconel 718 at High Temperature“. Key Engineering Materials 462-463 (Januar 2011): 1244–49. http://dx.doi.org/10.4028/www.scientific.net/kem.462-463.1244.

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The effect of heat treatment on tensile and creep properties of nickel-base superalloy, Inconel 718 in room and at high temperature was investigated. Solution treatment was applied on the as-received material at 980oC for 1 hour before water quenched followed by double aging treatments at 720oC and 621oC for 8 hours, respectively and then cooled in air. The tensile strength at elevated temperatures of 550oC and 650oC were slightly deteriorated for heat treated and as-received materials. Beside strength, significant difference was observed in the elongation. The elongation of heat treated samples drastically reduced to 4 to 5% only compared to that of the as received materials which exhibited more than 30% elongation. The significant increased in tensile strength is suspected due to the present of γ’, γ” and δ precipitates which pinned the movement of grain boundary and sliding. However, the present of these precipitates caused the material to become harder and brittle. Moreover, the increase in load from 70% to 90% UTS and in temperature significantly accelerated the creep rate.

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Bonneau, M. „Growth hormone response to GRF and insulin-induced hypoglycemia in Yorkshire and Meishan pigs“. American Journal of Physiology-Endocrinology and Metabolism 264, Nr. 1 (01.01.1993): E54—E59. http://dx.doi.org/10.1152/ajpendo.1993.264.1.e54.

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Plasma glucose and porcine growth hormone (GH) responses to insulin and/or growth hormone-releasing factor (GRF) challenges were determined in Yorkshire (Y) and Meishan (MS) castrated male pigs at 140 days of age. The decline in glucose levels observed during the first 30 min after insulin injection was similar between the two breeds. In Y pigs, GH concentrations increased sharply after insulin injection. The GH response to insulin was much smaller in MS than in Y pigs (101 +/- 82 vs. 1,077 +/- 124 ng.min.ml-1, P < 0.001 after 0.30 U/kg insulin). The GH response to GRF (10 micrograms/kg) did not differ significantly between the two breeds. The GH response was larger after combined insulin (0.20 U/kg) plus GRF than after GRF alone in Y pigs (1,512 +/- 229 vs. 463 +/- 401 ng.min.ml-1, P < 0.05), whereas it did not differ in MS pigs (714 +/- 164 vs. 507 +/- 127 ng.min.ml-1, P < 0.10). The present data demonstrate that the GH response to insulin is dramatically altered in MS pigs. A possible explanation to this result is that somatostatin tone would not be depressed by insulin-induced hypoglycemia in MS pigs.

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Jaber, Lina, Mahmod Amro, Hadeel Abu Tair, Shereen A. Bahader, Hanna Alalam, Suha Butmeh, Dalia Abu Hilal, Ingrid Brettar, Manfred G. Höfle und Dina M. Bitar. „Comparison of in situ sequence type analysis of Legionella pneumophila in respiratory tract secretions and environmental samples of a hospital in East Jerusalem“. Epidemiology and Infection 146, Nr. 16 (30.08.2018): 2116–21. http://dx.doi.org/10.1017/s0950268818002340.

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AbstractLegionella pneumophila genotyping is important for epidemiological investigation of nosocomial and community-acquired outbreaks of legionellosis. The prevalence of legionellosis in pneumonia patients in the West Bank was monitored for the first time, and the sequence types (STs) from respiratory samples were compared with STs of environmental samples from different wards of the hospital. Sputum (n = 121) and bronchoalveolar lavage (BAL) (n = 74) specimens were cultured for L. pneumophila; genomic DNA was tested by 16S rRNA polymerase chain reaction (PCR) amplification. Nested PCR sequence-based typing (NPSBT) was implemented on DNA of the respiratory and environmental PCR-positive samples. Only one respiratory specimen was positive for L. pneumophila by culture. BAL gave a higher percentage of L. pneumophila-positive samples, 35% (26/74) than sputum, 15% (18/121) by PCR. NPSBT revealed the following STs: ST 1 (29%, 7/24), ST 461 (21%, 5/24), ST 1037 (4%, 1/24) from respiratory samples, STs from environmental samples: ST 1 (28.5%, 4/14), ST 187 (21.4%, 3/14) and ST 2070, ST 461, ST 1482 (7.1%, 1/14) each. This study emphasises the advantage of PCR over culture for the detection of L. pneumophila in countries where antibiotics are indiscriminately used prior to hospital admission. ST 1 was the predominant ST in both respiratory and environmental samples.

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Catchings, Rufus D., Mark R. Goldman, Jamison H. Steidl, Joanne H. Chan, Amir A. Allam, Coyn J. Criley, Zhenning Ma et al. „Nodal Seismograph Recordings of the 2019 Ridgecrest Earthquake Sequence“. Seismological Research Letters 91, Nr. 6 (30.09.2020): 3622–33. http://dx.doi.org/10.1785/0220200203.

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Abstract The 2019 Ridgecrest, California, earthquake sequence included Mw 6.4 and 7.1 earthquakes that occurred on successive days beginning on 4 July 2019. These two largest earthquakes of the sequence occurred on orthogonal faults that ruptured the Earth’s surface. To better evaluate the 3D subsurface fault structure, (P- and S-wave) velocity, 3D and temporal variations in seismicity, and other important aspects of the earthquake sequence, we recorded aftershocks and ambient noise using up to 461 three-component nodal seismographs for about two months, beginning about one day after the Mw 7.1 mainshock. The ∼30,000Mw≥1 earthquakes that were recorded on the dense arrays provide an unusually large volume of data with which to evaluate the earthquake sequence. This report describes the recording arrays and is intended to provide metadata for researchers interested in evaluating various aspects of the 2019 Ridgecrest earthquake sequence using the nodal data set.

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Fridriksson, Joel K., Jeroen Homan, Rudy Wijnands, Mariano Méndez, Diego Altamirano, Edward M. Cackett, Edward F. Brown, Tomaso M. Belloni, Nathalie Degenaar und Walter H. G. Lewin. „RAPID COOLING OF THE NEUTRON STAR IN THE QUIESCENT SUPER-EDDINGTON TRANSIENT XTE J1701–462“. Astrophysical Journal 714, Nr. 1 (08.04.2010): 270–86. http://dx.doi.org/10.1088/0004-637x/714/1/270.

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Basevi, Claudio. „La doctrina cristológica del «himno» de Col 1, 15-20“. Scripta Theologica 31, Nr. 2 (23.01.2018): 317–44. http://dx.doi.org/10.15581/006.31.14550.

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SUMARIO: 1. Introducción. 2. Cristo es el «Hijo del amor» del Padre (v. 1, 13) y (v. 14). 3. El Hijo es imagen del Dios invisible, primogénito de toda criatura (v. 15). 4. Jesucristo: su poder universal y su primado ontológico (vv. 16 y 17). 4.1. Todo ha sido creado en Él por Él y para Él (v. 16).4.2. El primado ontológico de Cristo (v. 17). 5. Cristo «cabeza», , «principio» y primogénito» en la obra de la Redención (v. 18). 6. Cristo como Hijo de Dios (v. 19). 7. La obra de la Redención (v. 20). 7.1. La «reconciliación». 7.2. «La pacificación». 7.3. La universalidad de la Redención. 8. Una mirada de conjunto. 9. Conclusiones.

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Okpebholo, Eseohe G., Oluwatooyin F. Oludahunsi und Oluwole S. Ijarotimi. „Early Onset of Hypertension and Diabetes: Prevalence and Risk Factors among School Going Adolescents in Federal Capital Territory, North Central Nigeria“. International Journal of Research and Innovation in Applied Science X, Nr. I (2025): 279–91. https://doi.org/10.51584/ijrias.2025.1001023.

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This study on early onset of hypertension and diabetes in adolescents was carried out to determine the prevalence of Hypertension, Prediabetes and diabetes among school-going adolescents in the Federal Capital Territory Abuja Nigeria. A questionnaire was used to assess all parameters. 717 in-school boarding and Day Students aged 10–19 years of age were assessed. Statistical analysis was carried out using Statistical Product and Service Solutions (SPSS) version 23.0. Results showed that of the 717 sampled adolescents, 488 (68.1%) and 229(31.9) were Females and Males respectively. 286 Boarders and 431 Day Students. Participants ranged between ages 13-16years (59.7%) and 17-19yrs (40.3%). Cereals (51%) were the most consumed across the adolescent diet, while Dairy (2%), Eggs (1%) and fruit (1%) were the least consumed. 22.6% of adolescents were underweight, 1.7% Overweight and 0.4% Obese. The Tri ponderal Risk assessment showed 93.6% of adolescents are at Low Risk of disease onset, 3.6% moderate risk and 2.8% High Risk. Combined Risk factors observed was Less exercise, regular consumption of processed foods and (29.5%), Family History (21.6%) 6.7% Overweight and Obesity (4.2%), Prediabetes (6.7%) Smoking (4.2%). The mean Fasting Blood Glucose (FBG) was 4.2 ± 1.2 mmol/L. 9.7% and 2% males and female subjects had FBS >5.5mmol/ as either Prediabetic or Diabetic. A total prevalence of 82(11.7%) of adolescents were noted with prediabetes or Diabetes. Elevated systolic BP 17(2.4%), Elevated Diastolic BP 7(1%) and (systolic and/ or diastolic) 8(1.4%) were reported among the adolescents. The female Population had higher elevated scores in Blood Glucose Levels (7.1%) and Blood Pressure (3.2%), and the regression coefficient between BMI and other parameters was very weak (R<0.2) for Diabetes and Hypertension except for Systolic and Diastolic blood Pressure with statistical significance (p < 0.005).

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Kim, HyeonKi, Wooyeon Lee, Junsoo Kim, Dong Woo Shin, Young Hoon Choi, Wootaek Seo, Hee-Eon Lim et al. „A novel 2-2 5-5 model for stratifying liver metastasis burden in patients with pancreatic cancer.“ Journal of Clinical Oncology 43, Nr. 4_suppl (Februar 2025): 711. https://doi.org/10.1200/jco.2025.43.4_suppl.711.

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711 Background: In metastatic pancreatic cancer (MPC), hepatic metastasis is uniformly counted as just ‘one organ metastasis’ regardless of its metastatic tumor burden. This study aims to develop a novel stratification system for liver metastasis based on tumor burden, and to evaluate its prognostic significance in MPC patients. Methods: Patients with MPC treated at Seoul National University Bundang Hospital from 2011 to 2021 were included as the training cohort. Patients with liver-only metastasis were selected for analysis. Liver metastasis burden was categorized by the number and maximum diameter of metastases as measured from diagnostic CT images. Optimal cutoffs for metastasis number and size were determined using Cox proportional hazards regression, adjusted for chemotherapy regimen. An independent cohort from Seoul St. Mary’s Hospital and Hallym University Sacred Heart Hospital served as the validation group. The ‘H category classification’ suggested by the Japanese Society for Cancer of the Colon and Rectum (JSCCR) was also referenced. Results: A total of 1,257 patients were included, with 1,084 in the training cohort and 173 in the validation cohort. In the training cohort, data from 311 patients with liver-only metastasis were analyzed to derive the Two-two five-five (‘2-2 5-5’) criteria, classifying metastasis into Oligo-metastasis (≤2 metastases and ≤2 cm), Meso-metastasis (non-oligo and non-mega), and Mega-metastasis (≥5 metastases or ≥5 cm). Median overall survival (OS) significantly differed between the groups: Oligo (11.4 months), Meso (9.2 months, HR 1.66, 95% CI 1.14–2.43), Mega (5.6 months, HR 2.63, 95% CI 1.94–3.58) in the training cohort; Oligo (5.8 months) vs Mega (1.81 months, HR 1.94, 95% CI 1.16–3.22) in the validation cohort. Conclusions: This 2-2 5-5 model effectively stratifies MPC patients with hepatic metastasis into three prognostic groups, demonstrating significant survival differences in both training and validation cohorts. This could rationalize the independent therapeutic strategies by extent of hepatic metastasis. Demographic characteristics of patients classified according to “two-two five-five” criteria. Oligo-metastasis(n = 88) Meso-metastasis(n = 59) Mega-metastasis(n = 164) Total(n = 311) P-value* Age, median (range) 66.0 (33.2-91.0) 67.1(37.2-86.9) 68.7 (40.1-94.6) 67.9 (33.2-94.6) 0.587 Male, n (%) 43 (48) 36 (61) 91 (55) 170 (54) 0.330 Tumor location(Head), n(%) 47 (53) 27 (45) 60 (36) 134 (43) <0.05 Number of liver metastasis, median (range) 1 (1-2) 3 (1-4) 12 (2-14) 5 (1-14) <0.05 Maximal size of liver metastasis, cm (IQR)Average size of liver metastasis, cm (IQR) 10.6 (8.1-13.1)10.3 (8.0-12.1) 15.9 (10.1-24.2)13.5 (7.8-19.1) 21.6 (16.8-33.7)13.2 (10.5-19.2) 17.2 (10.9-25.2)11.9 (9.2-17.1) <0.05<0.05 CA19-9 (U/mL) 462 (103-1,334) 560 (89-1,480) 1,170 (100-9,500) 745 (100-3,700) <0.05

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Schneller, Beverly. „Rosemary Ashton. George Eliot: A Life. New York: Penguin Press. 1997. Pp. xiv, 465. $32.95. ISBN 0-713-99194-1.“ Albion 30, Nr. 2 (1998): 324–25. http://dx.doi.org/10.1017/s0095139000060555.

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Kutluk, M. Tezer, und Akif Yeşilipek. „Pediatric Cancer Registry in Turkey 2009-2018 (TPOG & TPHD).“ Journal of Clinical Oncology 37, Nr. 15_suppl (20.05.2019): e21510-e21510. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e21510.

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e21510 Background: In Children and adolescents aged 0-14, each year more than 200.000 new cancer cases are expected at global level. For the planning and implementation of an effective pediatric cancer control program, pediatric cancer registries are essential. The long term survival rates have been improved to 85% in high income countries, however it is still less than this in LMICs. This work presents the most updated results of the pediatric cancer registry in Turkey. Methods: Turkish Pediatric Oncology Group and Turkish Pediatric Hematology Association has established the Pediatric Cancer Registry in 2002. The childhood cancer cases registered between 2009-2018 was included in this analysis. International Childhood Cancer Classification System was used for the classification. Essential demographic findings, ICD-O-3 morphology and topography codes were recorded for each case. Results: During the 10 years from 2009 to 2018, 15713 cases were registered. For all cases, median age was 6.7 year (0-17; M/F 8838/6867, 3 hermaphrodite, 5 unknown). Age distribution was 0-4 yrs, 40.7%; 5-9 yrs, 24.4%; 10-14 yrs, 23.2%; 15-19 yrs, 11.7%) The distribution of the tumor types were [number of cases, percentage of total, median age yrs, M/F]: Leukemia (4368, 27.8%, 5.4, 2519/1849); Lymphoma & other RES tumors (2996, 19.1%, 9.7, 2012/979, 1 hermaphrodite & 4 unknown); CNS [brain & spinal] (2089, 13.3%, 7.1, 1142/947); Symphatetic system (1243, 7.9%, 2.4, 650/593); Retinoblastoma (358, 2.3%, 1.4, 204/154); Renal (788, 5.0%, 3.3, 369/419); Liver (260, 1.7%, 1.8, 143/117); Malignant bone (1030, 6.6%, 12.6, 566/464); Soft tissue sarcomas (1052, 6.7%, 7.4, 611/441); Germ cell (971, 6.2%, 8.4, 346/622, 2 hermaphrodite, 1 unknown); Carcinoma & other malignant epithelial (462, 2.9%, 13.7, 226/236); Other/non-specific malignant (96, 0.5%, 7.8, 50/46). Five year survival rate was found as 70.8%. Conclusions: This registry has been used widely among health care professionals since its establishment in 2002. Survival rates for children and adolescents has been improved to 70%. This level of survival is at the acceptable level for an upper middle income country. This registry became a useful source for investigator and decision makers at national and international level.

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Lee, Tsung Hung. „Ecological patterns of distribution on gradients of elevation and species diversity of snakes in southern Taiwan“. Amphibia-Reptilia 26, Nr. 3 (2005): 325–32. http://dx.doi.org/10.1163/156853805774408522.

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AbstractThe study was conducted in southern Taiwan, along a road traversing the study area from 287 to 1680 m a.s.l. from May to October 2003 to investigate the distribution patterns and species diversity of the snakes. A total of 69 individual snakes belonging to 16 species were recorded. The Shannon's index and evenness index of the full study area were 2.4337 and 0.8777, respectively. Moreover, evenness index was 401 to 700 m > 1001 to 1300 m > 701 to 1000 m > 1301 to 1600 m altitudinal zone. The Shannon's index, DMG, and the reciprocal form of the Berger-Parker index (1/d) were 1001 to 1300 m > 401 to 700 m > 701 to 1000 m > 1301 to 1600 m altitudinal zone. Thirty-seven snakes were found in natural forest, 12 in plantation forest, 8 in secondary forest, and 12 in agricultural lands. I concluded that the highest species richness and diversity are found in mid-altitudinal mountains in southern Taiwan.

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Lu, Jianan, Yue Zhang, Xingxuan Dong, Jiawen Lu, Chen Zhang, Jieyu Liu, Qingzhou Yu et al. „Association between MIC-1 and Type 2 Diabetes: A Combined Analysis“. Disease Markers 2019 (16.11.2019): 1–8. http://dx.doi.org/10.1155/2019/7284691.

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Background and Objectives. Type 2 diabetes mellitus (T2DM) is an epidemic disease that endangers human health seriously. Recently, a large number of reports have revealed that macrophage-inhibiting cytokine-1 (MIC-1) is linked with T2DM, but the results were inconclusive. The aim of this study was to perform bioinformatics analysis of the association between MIC-1 and T2DM. Material and Methods. Datasets and relevant literatures were searched in Gene Expression Omnibus (GEO), PubMed, Google Scholar, and Web of Science till September 20, 2019. Expression levels of MIC-1 were extracted, pooled, and compared between T2DM cases and controls. Results. In summary, 11 GEO datasets and 3 articles with 421 T2DM cases and 711 controls were finally included. The expression level of MIC-1 was significantly higher in T2DM patients compared with controls, with a standard mean difference (SMD) of 0.54 and a 95% confidence interval (95% CI) of 0.24-0.83; in blood samples, the difference was still significant (SMD=0.65; 95%CI=0.24‐1.06). Meanwhile, the expression level of MIC-1 plays a significant role in differentiating T2DM cases from controls; the combined sensitivity, specificity, and odds ratio were 0.83 (95%CI=0.72‐0.90), 0.59 (95%CI=0.45‐0.72), and 1.64 (95%CI=1.35‐1.99), respectively. The summary receiver operating characteristic (SROC) curve demonstrated that the area under the curve (AUC) was 0.81 (95%CI=0.77‐0.84). Conclusion. Our results suggested that the expression levels of MIC-1 were significantly higher in T2DM patients in multiple tissues including blood samples.

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Domínguez, L., P. Rodriguez Cundin, T. Dierssen-Sotos, V. Calvo-Río, N. Vegas-Revenga, A. Corrales, N. Palmou-Fontana et al. „POS1467-HPR SEVERE RESPIRATORY INFECTIONS IN RHEUMATOID ARTHRITIS PATIENTS WITH BIOLOGIC THERAPY. COMPARATIVE STUDY BETWEEN VACCINATED AND NON VACCINATED PATIENTS“. Annals of the Rheumatic Diseases 80, Suppl 1 (19.05.2021): 1018.2–1019. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3180.

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Background:Rheumatoid arthritis (RA) patients are at increased risk of severe infections due to the disease itself, and the immunosuppressive treatment. Vaccination programs are designed to decrease the risk of infections.Objectives:In patients with RA treated with biologic therapy (BT) our aim was to assess a) the incidence of severe respiratory infections and b) to compare the risk between vaccinated and non vaccinated patients.Methods:Observational study of 431 patients diagnosed with RA that iniciated BT. One group of patients participated in a vaccination program from October 2011 to October 2016 (Group 1). The other group was not included in the vaccination program (Group 2). The follow-up was made until June 2017 with a minimum follow-up period of 8 months and a maximum of 5.5 years.Information on severe respiratory infections, defined as those that required hospitalization or at least one dose of intravenous antibiotic treatment at the emergency room, was retrieved from the hospital medical records.Results:We studied 431 patients (335 women/96 men); mean age 63.4±13.7 years. In the vaccination program (group 1) were included 299 (69.37%) patients and in the group 2 132 patients (30.63%). The main features of both groups are summarized in Table 1.During the follow-up, we registered 299 hospital admissions due to severe respiratory infections in both groups (incidence density 9.9 (95% CI: 6.9-13.6).In group 1, vaccinated patients, this incidence density was reduced to 7.1 (95% CI: 4.1-11.6). Figure 1.The vaccination program reduced the general incidence of severe respiratory infection in 44%.Conclusion:RA patients with BT included in the vaccination program present a lower incidence of severe respiratory infections compared with non vaccinated patients.Table 1.Main general features at BT onsetGroup 1Vaccination programN=299Group 2Non vaccination programN=132pAge (years) mean±SD61.32±13.0467.97±14.170.32Women, n (%)231 (77.3%)105 (79.5%)0.59Duration of RA (months) mean±SD73.24±10.4112.62±60.2Positive RF/ Positive ACPA, n (%)177(59.2)/172 (57.52%)93(70.5%)98 (74.24%)0.02/0,01Erosive disease, n (%)116 (38.8%)70 (53%)0.06Vasculitis, n (%)15 (5%)2 (1.5%)0.08Interstitial lung disease n (%)12 (4%)7 (5.3%)0.54Subcutaneous nodules n (%)16 (5.4%)6 (4.5%)0.72Corticosteroids299 (100%)132 (100%)1Number of conventional DMARDs, mean±SD1.66±0.892.03±1.050.3Figure 1.Disclosure of Interests:None declared

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Homan, Jeroen, Michiel van der Klis, Joel K. Fridriksson, Ronald A. Remillard, Rudy Wijnands, Mariano Méndez, Dacheng Lin et al. „XTE J1701–462 AND ITS IMPLICATIONS FOR THE NATURE OF SUBCLASSES IN LOW-MAGNETIC-FIELD NEUTRON STAR LOW-MASS X-RAY BINARIES“. Astrophysical Journal 719, Nr. 1 (19.07.2010): 201–12. http://dx.doi.org/10.1088/0004-637x/719/1/201.

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Cheng, Fupeng, Yutian Yu, Yue Lu, Zhijie Wang, Yihan Ling, Chao Jing, Chengzhi Guan und Jianqiang Wang. „Performance of CoMnO Spinel Coating onto 441 SS for SOEC Interconnect Application“. Coatings 12, Nr. 11 (11.11.2022): 1723. http://dx.doi.org/10.3390/coatings12111723.

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In this study, CoMnO spinel was applied via atmospheric plasma spray onto 441 SS as SOEC interconnect coating. The performance of oxidation corrosion, electrical resistance, and Cr migration are evaluated. The influence rule was elucidated as the higher the plasma torch power and the thicker coating, the higher the deposition efficiency for the coated specimens. The long-term isothermal oxidation measurement was conducted under a simulated environment for 504 h. The CoMnO35 specimen had a small kp at 6.54 × 10−5 mg2 cm−4 h−1 below the CoMnO30 (7.1 × 10−5) one, and the bare steel sample (1.3 × 10−3). The area-specific resistance (ASR) depends on the temperature and time measured. The CoMnO35 specimen had a smaller Ea (0.61 eV) than the bare steel sample (0.91 eV) and CoMnO38 (0.85 eV). In addition, the CoMnO35 had a lower ASR (27.33 mΩ cm2) than the uncoated one (1.58 Ω cm2 for 670 h).

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Nelson, Joe. „Reviewer Acknowledgements for World Journal of English Language, Vol. 8, No. 2“. World Journal of English Language 8, Nr. 2 (25.09.2018): 43. http://dx.doi.org/10.5430/wjel.v8n2p43.

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World Journal of English Language (WJEL) would like to acknowledge the following reviewers for their assistance with peer review of manuscripts for this issue. Many authors, regardless of whether WJEL publishes their work, appreciate the helpful feedback provided by the reviewers. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Each of the reviewers listed below returned at least one review for this issue.Reviewers for Volume 8, Number 2Amelia Maria CavaJessica Aliaga LavrijsenKenan YerliMaría Luisa CarrióRoberto Martínez Mateo Joe NelsonEditorial AssistantOn behalf of,The Editorial Board of World Journal of English LanguageSciedu Press-----------------------------------------1120 Finch Avenue West, Suite 701-309, Toronto, ON., M3J 3H7, CanadaTel: 1-416-479-0028 ext. 218Fax: 1-416-642-8548Email: wjel@sciedupress.comWeb: http://wjel.sciedupress.com

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Mainali, Badri P., und Francis P. Zamborini. „Chemical Detection by Analyte-Induced Change in Electrophoretic Deposition of Gold Nanoparticles“. Journal of The Electrochemical Society 169, Nr. 1 (01.01.2022): 016504. http://dx.doi.org/10.1149/1945-7111/ac418c.

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The electrophoretic deposition (EPD) of citrate-stabilized Au nanoparticles (cit-Au NPs) occurs on indium tin oxide (ITO)-coated glass electrodes upon electrochemical oxidation of hydroquinone (HQ) due to the release of hydronium ions. Anodic stripping voltammetry (ASV) for Au oxidation allows the determination of the amount of Au NP deposition under a specific EPD potential and time. The binding of Cr3+ to the cit-Au NPs inhibits the EPD by inducing aggregation and/or reducing the negative charge, which could lower the effective NP concentration of the cit-Au NPs and/or lower the electrophoretic mobility. This lowers the Au oxidation charge in the ASV, which acts as an indirect signal for Cr3+. The binding of melamine to cit-Au NPs similarly leads to aggregation and/or lowers the negative charge, also resulting in reduction of the ASV Au oxidation peak. The decrease in Au oxidation charge measured by ASV increases linearly with increasing Cr3+ and melamine concentration. The limit of detection (LOD) for Cr3+ is 21.1 ppb and 16.0 ppb for 15.1 and 4.1 nm diameter cit-Au NPs, respectively. Improving the sensing conditions allows for as low as 1 ppb detection of Cr3+. The LOD for melamine is 45.7 ppb for 4.1 nm Au NPs.

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Steinfadt, Justin D. R., Lars Bildsten und Phil Arras. „PULSATIONS IN HYDROGEN BURNING LOW-MASS HELIUM WHITE DWARFS“. Astrophysical Journal 718, Nr. 1 (30.06.2010): 441–45. http://dx.doi.org/10.1088/0004-637x/718/1/441.

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Bian, Wei-Hao, Kai Huang, Chen Hu, Li Zhang, Qi-Rong Yuan, Ke-Liang Huang und Jian-Min Wang. „THE VARIABILITY OF OPTICAL Fe II EMISSION IN PG QSO 1700+518“. Astrophysical Journal 718, Nr. 1 (01.07.2010): 460–66. http://dx.doi.org/10.1088/0004-637x/718/1/460.

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Bodaghee, A., J. A. Tomsick, J. Rodriguez, S. Chaty, K. Pottschmidt und R. Walter. „BROADBANDSUZAKUOBSERVATIONS OF IGR J16207-5129“. Astrophysical Journal 719, Nr. 1 (20.07.2010): 451–58. http://dx.doi.org/10.1088/0004-637x/719/1/451.

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Oba, Y., N. Miyauchi, H. Hidaka, T. Chigai, N. Watanabe und A. Kouchi. „FORMATION OF COMPACT AMORPHOUS H2O ICE BY CODEPOSITION OF HYDROGEN ATOMS WITH OXYGEN MOLECULES ON GRAIN SURFACES“. Astrophysical Journal 701, Nr. 1 (23.07.2009): 464–70. http://dx.doi.org/10.1088/0004-637x/701/1/464.

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Lee, Hyun-chul, Guy Worthey und John P. Blakeslee. „EFFECTS OF α-ELEMENT ENHANCEMENT AND THE THERMALLY PULSING-ASYMPTOTIC GIANT BRANCH ON SURFACE BRIGHTNESS FLUCTUATION MAGNITUDES AND BROADBAND COLORS“. Astrophysical Journal 710, Nr. 1 (19.01.2010): 421–31. http://dx.doi.org/10.1088/0004-637x/710/1/421.

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Andrews, Sean M., Ian Czekala, D. J. Wilner, Catherine Espaillat, C. P. Dullemond und A. M. Hughes. „TRUNCATED DISKS IN TW Hya ASSOCIATION MULTIPLE STAR SYSTEMS“. Astrophysical Journal 710, Nr. 1 (19.01.2010): 462–69. http://dx.doi.org/10.1088/0004-637x/710/1/462.

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Hinkley, Sasha, Ben R. Oppenheimer, Douglas Brenner, Neil Zimmerman, Lewis C. Roberts, Ian R. Parry, Rémi Soummer et al. „DISCOVERY AND CHARACTERIZATION OF A FAINT STELLAR COMPANION TO THE A3V STAR ζ VIRGINIS“. Astrophysical Journal 712, Nr. 1 (02.03.2010): 421–28. http://dx.doi.org/10.1088/0004-637x/712/1/421.

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Scuderi, Louis J., Jason A. Dittmann, Jared R. Males, Elizabeth M. Green und Laird M. Close. „ON THE APPARENT ORBITAL INCLINATION CHANGE OF THE EXTRASOLAR TRANSITING PLANET TrES-2b“. Astrophysical Journal 714, Nr. 1 (12.04.2010): 462–68. http://dx.doi.org/10.1088/0004-637x/714/1/462.

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Tripathi, Anjali, Joshua N. Winn, John Asher Johnson, Andrew W. Howard, Sam Halverson, Geoffrey W. Marcy, Matthew J. Holman et al. „A PROGRADE, LOW-INCLINATION ORBIT FOR THE VERY HOT JUPITER WASP-3b“. Astrophysical Journal 715, Nr. 1 (28.04.2010): 421–28. http://dx.doi.org/10.1088/0004-637x/715/1/421.

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Norris, Jay P., Neil Gehrels und Jeffrey D. Scargle. „THRESHOLD FOR EXTENDED EMISSION IN SHORT GAMMA-RAY BURSTS“. Astrophysical Journal 717, Nr. 1 (14.06.2010): 411–19. http://dx.doi.org/10.1088/0004-637x/717/1/411.

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Espaillat, C., P. D'Alessio, J. Hernández, E. Nagel, K. L. Luhman, D. M. Watson, N. Calvet, J. Muzerolle und M. McClure. „UNVEILING THE STRUCTURE OF PRE-TRANSITIONAL DISKS“. Astrophysical Journal 717, Nr. 1 (14.06.2010): 441–57. http://dx.doi.org/10.1088/0004-637x/717/1/441.

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Soini, Hanna, Xi Pan, Amol Amin, Edward A. Graviss, Anees Siddiqui und James M. Musser. „Characterization of Mycobacterium tuberculosis Isolates from Patients in Houston, Texas, by Spoligotyping“. Journal of Clinical Microbiology 38, Nr. 2 (2000): 669–76. http://dx.doi.org/10.1128/jcm.38.2.669-676.2000.

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Mycobacterium tuberculosis isolates (n= 1,429) from 1,283 patients collected as part of an ongoing population-based tuberculosis epidemiology study in Houston, Texas, were analyzed by spoligotyping and IS6110 profiling. The isolates were also assigned to one of three major genetic groups on the basis of nucleotide polymorphisms located at codons 463 and 95 in the genes (katG and gyrA) encoding catalase-peroxidase and the A subunit of DNA gyrase, respectively. A total of 225 spoligotypes were identified in the 1,429 isolates. There were 54 spoligotypes identified among 713 isolates (n= 623 patients) assigned to 73 IS6110 clusters. In addition, among 716 isolates (n = 660 patients) with unique IS6110 profiles, 200 spoligotypes were identified. No changes were observed either in the IS6110 profile or in the spoligotype for the 281 isolates collected sequentially from 133 patients. Five instances in which isolates with slightly different spoligotypes had the same IS6110 profile were identified, suggesting that in rare cases isolates with different spoligotypes can be clonally related. Spoligotypes correlated extremely well with major genetic group designations. Only three very similar spoligotypes were shared by isolates from genetic groups 2 and 3, and none was shared by group 1 and group 2 organisms or by group 1 and group 3 organisms. All organisms belonging to genetic groups 2 and 3 failed to hybridize with spacer probes 33 to 36. Taken together, the results support the existence of three distinct genetic groups of M. tuberculosis organisms and provide new information about the relationship between IS6110 profiles, spoligotypes, and major genetic groups of M. tuberculosis.

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Lima, Leandro Gregorut, Barbara Fialho Carvalho Sampaio, Marco Aurélio Silvério Neves, Alexandre Póvoa Barbosa, Victor Edmond Seid und Fernanda Degobbi T. Q. S. Lopes. „Implantação do protocolo de recuperação rápida para artroplastia total do quadril em hospital público do estado de São Paulo – Brasil“. Revista Brasileira de Ortopedia 59, Nr. 02 (April 2024): e297-e306. http://dx.doi.org/10.1055/s-0043-1771489.

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Resumo Objetivo Avaliar os resultados da implantação do Protocolo de Recuperação Rápida (PRR), prática médica baseada em evidências científicas, para cirurgia eletiva de artroplastia total do quadril principalmente comparando à Taxa Média de Internação Hospitalar nacional de 7.1 dias. Métodos 98 pacientes submetidos a cirurgia eletiva de artroplastia total do quadril pela via direta anterior, via anterolateral e via posterior foram incluídos no PRR no período de dezembro de 2018 a março de 2020 sendo acompanhados no pré-operatório, intraoperatório e pós-operatório imediato. Resultados a Taxa Média de Permanência Hospitalar foi de 2,8 dias, sendo 2,1 dias para a Via de Acesso Anterior, 3,0 dias para via de acesso anterolateral e 4,1 dias para via de acesso posterior. O tempo médio de cirurgia foi de 90 minutos, 19 (19,39%) dos pacientes foram encaminhados à UTI no pós-operatório, no entanto nenhum deles operado pela via direta anterior. Não tivemos casos de trombose venosa profunda (TVP), embolia pulmonar (TEP) ou lesão neurológica, 19 (19,39%) pacientes tiveram sangramento pós-operatório com necessidade de troca de curativo, 4 (4,08%) necessidade de transfusão sanguínea, 2 (2,04%) pacientes apresentaram instabilidade do implante, 1(1,02%) paciente teve fratura durante a cirurgia e 1(1,02%) paciente faleceu por complicações cardíacas. Conclusão O PRR pode ser uma alternativa viável para diminuir o tempo de internação e as complicações pós-operatórias imediatas para a cirurgia eletiva de artroplastia total do quadril diminuindo 2 a 3 vezes o tempo de internação dos pacientes quando comparado com a média nacional de 7,1 dias.

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Hendriks, D. M. D., J. van Huissteden, A. J. Dolman und M. K. van der Molen. „The full greenhouse gas balance of an abandoned peat meadow“. Biogeosciences 4, Nr. 3 (27.06.2007): 411–24. http://dx.doi.org/10.5194/bg-4-411-2007.

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Abstract. Globally, peat lands are considered to be a sink of CO2, but a source when drained. Additionally, wet peat lands are thought to emit considerable amounts of CH4 and N2O. Hitherto, reliable and integrated estimates of emissions and emission factors for this type of land cover have been lacking and the effects of wetland restoration on methane emissions have been poorly quantified. In this paper we estimate the full greenhouse gas (GHG) balance of a restored natural peat land by determining the fluxes of CO2, CH4 and N2O through atmosphere and water, while accounting for the different Global Warming Potentials (GWP's). The site is an abandoned agricultural peat meadow, which has been converted into a wetland nature reserve ten years ago, after which the water level was raised. GHG fluxes were measured continuously with an eddy covariance system (CO2) and flux chamber measurements (CH4 and N2O). Meteorological and hydrological measurements were collected as well. With growing seasons of respectively 192, 168 and 129 days, the annual net ecosystem exchange of CO2 (NEE) was −446+±83 g C m−2 yr−1 for 2004, −311±58 g C m−2 yr−1 for 2005 and −232±57 g m−2 yr−1 for 2006. Ecosystem respiration (Reco) was estimated as 869±668 g C m−2 yr−1 for 2004, 866±666 g C m−2 yr−1 for 2005 and 924±711 g C m−2 yr−1 for 2006. CH4 emissions from the saturated land and water surfaces were high compared to the relatively dry land. Annual weighted CH4 emissions were 31.27±20.40 g C m−2 yr−1 for 2005 and 32.27±21.08 g C m−2 yr−1 for 2006. N2O fluxes were too low to be of significance. The water balance of the area was dominated by precipitation and evapotranspiration and therefore fluxes of carbon and CH4 through seepage, infiltration and drainage were relatively small (17.25 g C m−2 yr−1). The carbon-balance consisted for the largest part of CO2 uptake, CO2 respiration and CH4 emission from water saturated land and water. CO2 emission has decreased significantly as result of the raised water table, while CH4 fluxes have increased. In GWP's the area was a small net GHG sink given as CO2-equiv. of −86 g m−2 yr−1 (over a 100-year period).

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Onigbinde, T. A., A. H. Wu, M. Johnson, Y. S. Wu, W. L. Collinsworth und M. J. Simmons. „Clinical evaluation of an automated chemical inhibition assay for lactate dehydrogenase isoenzyme 1“. Clinical Chemistry 36, Nr. 10 (01.10.1990): 1819–22. http://dx.doi.org/10.1093/clinchem/36.10.1819.

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Abstract We evaluated an automated assay for lactate dehydrogenase (LD; EC 1.1.1.27) isoenzymes, supplied by Boehringer Mannheim Diagnostics (BMD) and based on selective chemical inhibition of non-LD-1 isoenzymes by guanidine thiocyanate. Results were compared with the Roche Isomune LD-1 method. The Hitachi 717 analyzer was used to measure enzyme activity for both procedures in 229 serum samples. One hundred specimens were also analyzed by the Helena rapid electrophoresis (REP) method. We determined the limit of linearity of the BMD method to be about 1200 U of LD-1 per liter. The analytical correlation of BMD (y) with Isomune (x) yielded y = 1.0x + 0.5 U/L, r = 0.997, Sy/x = 16.9 (range 20-1397 U/L). The regression equation for BMD vs REP was y = 1.1x + 7.2% (r = 0.800, Sy/x = 7.4, range 14-83%). Average values for within-run precision for low (38 U/L), medium (180 U/L), and high (865 U/L) controls were 4.1%, 1.0%, and 0.5%, respectively (16 trials of six each). The average values for run-to-run precision were 4.1%, 1.7%, and 1.1%, respectively, for these controls (n = 16). We used receiver-operating characteristic curves to determine optimum decision limits. Using an LD-1 cutoff of 40% of total LD, we obtained a clinical sensitivity of 97-100% and a specificity of 95% when blood was collected during the optimum interval, 24-48 h after the onset of chest pain. We conclude that the BMD LD-1 assay is equivalent to the immunochemical and electrophoretic assays for measuring the LD-1 isoenzyme.

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جاسم الجبوري, اسراء ابراهيم, und عادل طه شلال فندي الحديثي. „التحليل المكاني لمتوسط حجم الأسرة في حضر محافــــــظة صلاح الــــديـــن لعام 2021م وتوقعاتها المستقبلية“. Journal of Tikrit University for Humanities 30, Nr. 10, 1 (22.10.2023): 88–111. http://dx.doi.org/10.25130/jtuh.30.10.1.2023.06.

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يكشف هذا البحث واقع حجم الاسرة في حضر محافظة صلاح الدين وبتباين متوسط حجمها في وحداتها الادارية لعام 2021، والتي تحكمها جملة من المتغيرات الاقتصادية والاجتماعية والديموغرافية، وبيان توقعاتها المستقبلية لعام 2030، وتفسير ماهية التباين في حجوم الاسر ومعطيات توزيعها المكاني. وقد تبين ان اعلى معدل لحجم الاسرة في 2021م، سجل في ناحية المعتصم (8,1) افراد في حين كان ادنى معدل في ناحية دجلة والبالغ (4,1) افراد، وبحلول 2030م انخفض متوسط حجم الاسرة الى (6) شخص/اسرة على مستوى حضر المحافظة ككل، ليسجل اعلى معدل في ناحية المعتصم (7,1) افراد، وادنى معدل في ناحية دجلة والبالغ (4,1) افراد، وبفعل العوامل الاقتصادية والاجتماعية والديموغرافية التي اثرت وتؤثر في متوسط حجم الأسرة في حضر المحافظة، مما ادى الى ميل حجم الاسر نحو التصغير، ليبلغ الفرق بين سنة الاساس وسنة الهدف (1) فرد.

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Singh, B., J. Mthombeni, G. Olorunfemi, M. Goosen, E. Cutler, H. Julius, Z. Brukwe und A. Puren. „Evaluation of the accuracy of the Asanté assay as a point-of-care rapid test for HIV-1 recent infections using serum bank specimens from blood donors in South Africa, July 2018 - August 2021“. South African Medical Journal 113, Nr. 10 (23.10.2023): 42–48. http://dx.doi.org/10.7196/samj.2023.v113i10.678.

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Background. Point-of-care (POC) rapid recency testing can be used as a cost-effective tool to identify recently infected individuals (i.e. infected within the last 12 months) in near-real time, support epidemic control and identify hotspots for transmission as part of recent infection surveillance. Objective. To evaluate the performance of the Asanté (HIV-1) rapid recency assay as a POC rapid test among blood donors in South Africa (SA). Methods. The study was a cross-sectional and validity study of the Asanté HIV-1 Rapid Recency Assay performed on 715 consecutively archived plasma donor specimens from the SA National Blood Services to determine their recency and established HIV infection status. ELISA and rapid assays for HIV antibody detection were used as the reference-testing standard for confirming an infection, while the Maxim HIV-1 limiting antigen (LAg) avidity assay was used as a reference for comparing HIV recency status. Validity tests (sensitivity, specificity, negative and positive predictive values) and Cohen-Kappa tests of the agreement were conducted to compare the Asanté HIV-1 rapid recency assay results with the reference tests. Results. Of the 715 studied blood samples, 63.1% (n=451/715) were confirmed to be HIV-positive based on the reference standard. The sensitivity and specificity of the Asanté HIV-1 rapid recency assay in diagnosing established HIV infection compared to the ELISA were 98.4% (95% CI 96.7 - 99.3) and 99.6% (95% CI 97.6 - 100), respectively. Compared with HIV rapid assay, the sensitivity and specificity of the Asanté HIV-1 rapid recency assay was 98.7% (95% CI 97.0 - 99.4) and 99.2% (95% CI 97.1 - 100), respectively. Of the 451 HIV-positive blood samples, 43% were confirmed as recent HIV infections by the Maxim HIV-1 LAg avidity assay. There was high agreement between the Asanté HIV-1 rapid recency assay and the Maxim HIV-1 LAg avidity assay (94.1%, k=0.879, p<0.0001). The sensitivity and specificity of the Asante HIV-1 assay was 89.4% (95% CI 84.0 - 93.0) and 97.7% (95% CI 94.8 - 99.0), respectively. Conclusion. The Asanté HIV-1 rapid recency assay test results demonstrated high accuracy (>90%) compared with the HIV ELISA and rapid assays for determining established infection and the Maxim HIV-1 LAg avidity assay for classifying recent HIV-1 infections. The assay’s sensitivity for established infections was below the World Health Organization criteria (<99%) for POC devices. The Asanté HIV-1 rapid recency assay can be used to distinguish between recent and long-term infections, but may not be considered a POC test for determining HIV infection.

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Bellerby, R. G. J., K. G. Schulz, U. Riebesell, C. Neill, G. Nondal, T. Johannessen und K. R. Brown. „Marine ecosystem community carbon and nutrient uptake stoichiometry under varying ocean acidification during the PeECE III experiment“. Biogeosciences Discussions 4, Nr. 6 (13.12.2007): 4631–52. http://dx.doi.org/10.5194/bgd-4-4631-2007.

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Abstract. Inorganic carbon and nutrient biogeochemical responses were studied during the 2005 Pelagic Ecosystem CO2 Enrichment (PeECE III) study. Inverse analysis of the temporal inorganic carbon dioxide system and nutrient variations was used to determine the net community stoichiometric uptake characteristics of a natural pelagic ecosystem production perturbed over a range of pCO2 scenarios (350, 700 and 1050 μatm). Nutrient uptake showed no sensitivity to CO2 treatment. There was enhanced carbon production relative to nutrient consumption in the higher CO2 treatments which was positively correlated with the initial CO2 concentration. There was no significant calcification response to changing CO2 in Emiliania huxleyi by the peak of the bloom and all treatments exhibited low particulate inorganic carbon production (~15 μmol kg−1). With insignificant air-sea CO2 exchange across the treatments, the enhanced carbon uptake was due to increase organic carbon production. The inferred cumulative C:N:P stoichiometry of organic production increased with CO2 treatment from 1:6.3:121 to 1:7.1:144 to 1:8.25:168 at the height of the bloom. This study discusses how ocean acidification may incur modification to the stoichiometry of pelagic production and have consequences for ocean biogeochemical cycling.

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TÎRZIU, EMIL, ROMEU LAZĂR, CLAUDIA SALA, ILEANA NICHITA, ADRIANA MORAR, MONICA ŞEREŞ und KÁLMÁN IMRE. „Salmonella in Raw Chicken Meat from the Romanian Seaside: Frequency of Isolation and Antibiotic Resistance“. Journal of Food Protection 78, Nr. 5 (01.05.2015): 1003–6. http://dx.doi.org/10.4315/0362-028x.jfp-14-460.

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The purpose of this study was to investigate the occurrence of Salmonella in raw chicken meat samples collected at the Romanian seaside and to evaluate the antimicrobial susceptibility of the isolates. In 2012, 317 chicken meat samples from slaughterhouses (n = 289) and retail markets (n = 28) were evaluated. Overall, 13.2% (42) of the samples contained Salmonella; 12.8% (37) and 17.8% (5) from the chicken carcasses at slaughterhouses and the fresh meat from retail markets, respectively. Eight serotypes of Salmonella enterica subsp. enterica were identified: Infantis (18 isolates), Bredeney (7), Virchow (6), Djugu (4), Grampian (4), Brandenburg (1), Derby (1), and Ruzizi (1). The isolates were resistant to tetracycline (66.6% of isolates), nalidixic acid (64.3%), sulfamethoxazole (64.3%), ciprofloxacin (61.9%), streptomycin (59.5%), trimethoprim (33.3%), ampicillin (9.5%), chloramphenicol (7.1%), and gentamicin (2.4%). No resistance was found to cefotaxime and ceftazidime. Thirty (71.4%) of the 42 tested isolates had multidrug resistance patterns to at least two antimicrobials. This survey highlighted a multidrug-resistant Salmonella contamination rate in raw chicken meat in this area of Romania, which can seriously threaten human health.

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Kojima, Takashi, Kei Muro, Eric Francois, Chih-Hung Hsu, Toshikazu Moriwaki, Sung-Bae Kim, Se-Hoon Lee et al. „Pembrolizumab versus chemotherapy as second-line therapy for advanced esophageal cancer: Phase III KEYNOTE-181 study.“ Journal of Clinical Oncology 37, Nr. 4_suppl (01.02.2019): 2. http://dx.doi.org/10.1200/jco.2019.37.4_suppl.2.

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2 Background: Patients with advanced esophageal cancer after first-line chemotherapy (chemo) have a poor prognosis and limited treatment options. We present results of the phase 3 KEYNOTE-181 study of pembrolizumab vs investigator’s choice chemo as second-line therapy for patients (pts) with advanced/metastatic squamous cell carcinoma (SCC) and adenocarcinoma of the esophagus or Siewert type I adenocarcinoma of the EGJ (NCT02564263). Methods: Eligible pts were randomized 1:1 to pembrolizumab 200 mg Q3W for up to 2 years or investigator’s choice chemo of paclitaxel, docetaxel, or irinotecan. Randomization was stratified by histology (SCC vs adenocarcinoma) and region (Asia vs rest of world). Primary end points were OS in the SCC, PD-L1 combined positive score (CPS) ≥10, and ITT populations. Results: 628 pts were randomized including 401 with SCC, and 222 with CPS ≥10. As of October 15, 2018, the median follow-up was 7.1 mo (pembrolizumab) vs 6.9 mo (chemo). Pembrolizumab was superior to chemo for OS in CPS ≥10 (N=222; median 9.3 vs 6.7 mo; HR 0.69; 95% CI 0.52-0.93; P=0.0074). The 12-mo OS rate in pts with CPS ≥10 was 43% vs 20%. There was clinically meaningful improvement in OS with pembrolizumab vs chemo in pts with SCC, but this was not statistically significant per prespecified boundaries (N=401; 8.2 mo vs 7.1 mo; HR 0.78; 95% CI 0.63-0.96; P=0.0095). In the ITT population, while directionally favorable, the difference in OS was not statistically significant (N=628; 7.1 mo vs 7.1 mo; HR 0.89; 95% CI 0.75-1.05; P=0.0560). Fewer pts had any-grade (64% vs 86%) or grade 3-5 (18% vs 41%) drug-related AEs with pembrolizumab vs chemo. Conclusion: Pembrolizumab significantly improved OS compared with chemo as second-line therapy for advanced esophageal cancer with PD-L1 CPS ≥10, with a more favorable safety profile. These data support pembrolizumab as a new second-line standard of care for esophageal cancer with PD-L1 CPS ≥10. The phase 3 KEYNOTE-590 study of pembrolizumab plus chemo as first-line therapy for advanced esophageal cancer is ongoing (NCT03189719). Clinical trial information: NCT02564263.

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Anita, Sofia, und Itnawita. „KARAKTERISASI ZEOLIT DARI MINERAL KAOLIN YANG BERASAL DARI DESA SENCALANG KABUPATEN INDRA GIRI HILIR“. Photon: Jurnal Sain dan Kesehatan 4, Nr. 2 (30.05.2014): 43–46. http://dx.doi.org/10.37859/jp.v4i2.180.

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Mineral kaolin yang bersal dari Desa Sencalang Kecamatan Kerintang Kabupaten Indra Giri Hilir dapat digunakan sebagai bahan baku pembuatan zeolit karena mengandung SiO2 yang cukup besar yaitu 60,49-83,02 % dan Al2O3 10,63-24,19 %. Zeolit yang dibuat dari peleburan 25 g kaolin dan 35 g NaOH serta penambahan silikat dan aluminat 1:1, mempunyai karakter yang mirip dengan zeolit A. Hasil difraksi sinar-X menunjukkan adanya pola difraksi sudut 2θ berturut turut 7,20: 10,12; 16,13; 21,70; 24,00; 30,79; 34,24; 36,63; 42,63 dan adanya regangan asimetris O-Si-O atau O-Al-O pada bilangan gelombang 1007 dan 1006 cm -1, 715-720 cm-1 regangan simetris O-Si-O atau O-Al-O dari ikatan TO4 tetrahedral. Bilangan gelombang 463 dan 456 cm-1 merupakan vibrasi tekuk TO4 tertahedral sedangkan serapan cincin ganda terlihat tajam pada nilangan gelombang 559 cm-1.

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Blanco, Ignacio, Isidro Diego, Patricia Bueno, Sergio Pérez-Holanda, Francisco Casas-Maldonado und Marc Miravitlles. „Prevalence of α1-antitrypsin PiZZ genotypes in patients with COPD in Europe: a systematic review“. European Respiratory Review 29, Nr. 157 (21.07.2020): 200014. http://dx.doi.org/10.1183/16000617.0014-2020.

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The percentage of α1-antitrypsin protease inhibitor ZZ (PiZZ) genotypes in patients with COPD is controversial, with large differences among various studies. We aimed to estimate the prevalence of PiZZ in COPD patients from 20 European countries with available data, according to the number of PiZZ and COPD individuals in each country.A systematic review was conducted to select European countries with reliable data on the prevalence of PiZZ and COPD. We created a database with the following data: 1) total population and population aged ≥40 years according to the Eurostat database; 2) number and 95% CI of PiZZ patients aged ≥40 years; 3) application of a conversion factor of genetic penetrance of 60%; 4) number of COPD individuals, with 95% CI, aged ≥40 years; and 5) calculation of the PiZZ/COPD ratio. Finally, results were presented using an Inverse Distance Weighted Interpolation map.We found 36 298 (95% CI 23 643–56 594) PiZZ individuals at high risk and 30 849 709 (95% CI 21 411 293–40 344 496) COPD patients, with a PiZZ/COPD ratio of 0.12% (range 0.08–0.24%), and a prevalence of 1 out of 408 in Northern, 1 out of 944 in Western, 1 out of 1051 in Central, 1 out of 711 in Southern, and 1 out of 1274 in Eastern Europe.These data may be useful to plan strategies for future research and diagnosis, and to rationalise the available therapeutic resources.

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Deshmukh, Jay, Libin Zhang, Ning Zhang, Animesh Dutta, Ziwei Ye, Hussein Hijazi, Meng Yue, Meredith Tulloch, Michel Johnson und Michael Metzger. „Improving Sodium Manganese Hexacyanoferrate with Optimized Synthesis Conditions, Effective Drying, and Small Amounts of Nickel“. Journal of The Electrochemical Society 172, Nr. 2 (01.02.2025): 020516. https://doi.org/10.1149/1945-7111/adb13e.

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Prussian Blue Analogs are a promising class of positive electrode materials for sodium-ion batteries that can be synthesized at low temperatures using only Earth-abundant elements like sodium, iron, and manganese. Their open framework structure allows them to sustain high current densities but also makes them prone to absorption of moisture. We improve the specific capacity of sodium manganese hexacyanoferrate (MnHCF) by optimizing synthesis and processing conditions, enabling a material-level energy density of 562 Wh kg−1, which is on par with lithium iron phosphate. We remove interstitial water from these materials by rigorous drying. We also demonstrate a factor two improvement in cycling life of MnHCF by substituting only 3 at. % Ni for Mn and leaving some vacancies, which leads to 80% capacity retention after 3,500 h (∼5 months) of cycling in Na half cells at 0.2 C between 2.0 and 4.1 V and an ability to retain >85% capacity at a high current density of 10 C.

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