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Zeitschriftenartikel zum Thema „813/.52 b“

Autor: Grafiati

Veröffentlicht am 28. Juli 2024

Zuletzt aktualisiert am 31. Juli 2025

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Ramirez, Cody, Felix Frenkel, Olga Plotnikova, et al. "Identification of predicted neoantigen vaccine candidates in follicular lymphoma patients." Journal of Clinical Oncology 38, no. 15_suppl (2020): 8054. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.8054.

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8054 Background: Follicular lymphoma (FL) is incurable with conventional therapies and poorly responsive to immune checkpoint blockade. There is a need for new therapies without long-term complications of chemotherapy and with curative potential. We hypothesize that FL contains tumor-specific mutant antigens (TSMAs) that can be targeted by the immune system by vaccination. Recent reports have highlighted the potential for unique immunoglobulin peptides to elicit immune response in lymphomas. We utilized whole exome sequencing (WES) and RNA sequencing (RNA-Seq) of FL patient samples to infer HL

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Burden, Eleanor G., Timothy J. Batten, Christopher D. Smith, and Jonathan P. Evans. "Reverse total shoulder arthroplasty." Bone & Joint Journal 103-B, no. 5 (2021): 813–21. http://dx.doi.org/10.1302/0301-620x.103b.bjj-2020-2101.

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Aims This systematic review asked which patterns of complications are associated with the three reverse total shoulder arthroplasty (RTSA) prosthetic designs, as classified by Routman et al, in patients undergoing RTSA for the management of cuff tear arthropathy, massive cuff tear, osteoarthritis, and rheumatoid arthritis. The three implant design philosophies investigated were medial glenoid/medial humerus (MGMH), medial glenoid/lateral humerus (MGLH), and lateral glenoid/medial humerus (LGMH). Methods A systematic review of the literature was performed via a search of MEDLINE and Embase. Two

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Halkes, Constantijn J. M., Inge Jedema, Judith Olde Wolbers, et al. "Low Incidence of Post-Transplant EBV-Related Disease After Alemtuzumab-Mediated T Cell Depletion Is Explained by the Differential Susceptibility to Alemtuzumab of B Cells and Protective CD8 and CD4 T Cells." Blood 116, no. 21 (2010): 2330. http://dx.doi.org/10.1182/blood.v116.21.2330.2330.

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Abstract Abstract 2330 In vivo T cell depletion with anti-thymocyte globulin (ATG) or alemtuzumab (anti-CD52) before reduced intensity allogeneic stem cell transplantation (alloSCT) in combination with in vitro T cell depletion with alemtuzumab reduces the risk of GVHD. Detectable levels of circulating antibodies are present up to several months after the alloSCT, leading to a delayed immune reconstitution which is associated with an increased incidence of opportunistic infections and early relapses. Prior to 2007, combined in vitro (Alemtuzumab 20 mg added “to the bag”) and in vivo T cell dep

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Lenshin, Alexander S., Konstantin A. Barkov, Natalya G. Skopintseva, Boris L. Agapov та Evelina P. Domashevskaya. "Влияние режимов электрохимического травления при одностадийном и двухстадийном формировании пористого кремния на степень окисления его поверхностных слоев в естественных условиях". Kondensirovannye sredy i mezhfaznye granitsy = Condensed Matter and Interphases 21, № 4 (2019): 534–43. http://dx.doi.org/10.17308/kcmf.2019.21/2364.

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В работе методами растровой электронной микроскопии и ультрамягкойрентгеновской эмиссионной спектроскопии были проведены исследования особенностейформирования многослойных структур пористого кремния и установлено влияние изменения плотности тока при электрохимическом травлении монокристаллических пластин кремния на фазовый состав поверхностных слоев сформированной пористой структуры.     ЛИТЕРАТУРА1. Moshnikov V., Gracheva I., Lenshin A., Spivak Yu. Porous silicon with embedded metal oxides for gassensing applications // Journal of Non-Crystalline Solids, 2012 v.

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Aggarwal, A., R. Gupta, R. Chatterjee, et al. "POS0773 AUTOANTIBODIES IN A MULTI-INSTITUTIONAL INDIAN COHORT (INSPIRE) OF SLE PATIENTS: PREVALENCE, CLUSTER ANALYSIS AND PHENOTYPE ASSOCIATION." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 673. http://dx.doi.org/10.1136/annrheumdis-2022-eular.4173.

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BackgroundSystemic Lupus Erythematosus (SLE) is characterized by an array of autoantibodies. Different autoantibodies have been associated with different clinical features like anti-dsDNA antibodies with nephritis and anti-phospholipid antibodies with pregnancy loss. However, the prevalence of autoantibodies has been variable across different ethnic groups. Data on the Indian population is limited.ObjectivesTo assess the prevalence of different autoantibodies in a multi-institutional cohort (INSPIRE) of Indian SLE patients and to test their association with various clinical features using clus

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Agarwal, Ishan, Akshay Khandekar, Uma Ramakrishnan, Raju Vyas, and Varad B. Giri. "Two new species of the Ophisops microlepis (Squamata: Lacertidae) complex from northwestern India with a key to Indian Ophisops." Journal of Natural History 52, no. 13-16 (2018): 819–47. https://doi.org/10.1080/00222933.2018.1436203.

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Agarwal, Ishan, Khandekar, Akshay, Ramakrishnan, Uma, Vyas, Raju, Giri, Varad B. (2018): Two new species of the Ophisops microlepis (Squamata: Lacertidae) complex from northwestern India with a key to Indian Ophisops. Journal of Natural History 52 (13-16): 819-847, DOI: 10.1080/00222933.2018.1436203, URL: http://dx.doi.org/10.1080/00222933.2018.1436203

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PAI, Chih-Hung, Kuo-Min KO, and Troy SANTOS. "A Study of the Effect of Service Recovery on Customer Loyalty Based On Marketing Word Of Mouth in Tourism Industry." Revista de Cercetare si Interventie Sociala 64 (March 6, 2019): 74–84. http://dx.doi.org/10.33788/rcis.64.6.

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Akamavi, R K., Mohamed, E., Pellmann, K., & Xu, Y. (2015). Key determinants of passenger loyalty in the low-cost airline business. Tourism Management, 46, 528-545. Baldus, B.J., Voorhees, C., & Calantone, R. (2015). Online brand community engagement: Scale development and validation. Journal of Business Research, 68(5), 978-985. Boo, H.V. (2017). Service Environment of Restaurants: Findings from the youth customers. Journal of Asian Behavioural Studies, 2(2), 67-77. Bowen, T.J., & Chen, S.L. (2015). Transitioning Loyalty Programs: A Commentary on the Relationship Between Customer L

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BRIT Press. "Guide to the Vascular Flora of Picture Creek Diabase Barrens, Granville County, North Carolina, U.S.A." Journal of the Botanical Research Institute of Texas 12, no. 1 (2018): 322. https://doi.org/10.17348/jbrit.v12.i1.939.

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Jennifer S. Stanley, Alexander Krings, Jon M. Stucky, and Richard R. Braham. 2019. Guide to the Vascular Flora of Picture Creek Diabase Barrens, Granville County, North Carolina, U.S.A. Sida, Botanical Miscellany 51. (ISSN: 0883-1475; ISBN-13: 978-1-889878-52-2; pbk). Botanical Research Institute of Texas Press, 1700 University Dr., Fort Worth, Texas 76107, U.S.A. (Orders: www.shopbrit.org, orders@ brit.org, 1-817-332-4441). $45.00 US, 367 pp., 300+ color photographs, b/w line drawings, maps, references, index, 7" × 10".

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Castillo, Jorge J., Flora Mulkey, Susan Geyer, et al. "Obesity Is An Adverse Prognostic Factor For Overall and Disease-Free Survival In Adult Acute Promyelocytic Leukemia But Not In Acute Myeloid Leukemia: A Pooled Analysis From Four Alliance Prospective Studies." Blood 122, no. 21 (2013): 832. http://dx.doi.org/10.1182/blood.v122.21.832.832.

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Abstract Introduction There are mounting data associating obesity with an increased risk of developing acute myeloid leukemia (AML) and acute promyelocytic leukemia (APML). However, the role of obesity in the outcome of patients with AML and APML has not been extensively evaluated. In this study, we assess the effect of obesity in relapse and survival rates of clinical trial patients with AML and APML. Methods Data on patients ≥18 years from 4 prospective clinical trials from the Cancer and Leukemia Group B (Alliance) were pooled for this analysis (n=2,093). This reflects exclusion of 72 patie

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Burés Jelstrup, Anniken, Esther Pomares, and Rafael Navarro. "Relationship between Aflibercept Efficacy and Genetic Variants of Genes Associated with Neovascular Age-Related Macular Degeneration: The BIOIMAGE Trial." Ophthalmologica 243, no. 6 (2020): 461–70. http://dx.doi.org/10.1159/000508902.

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<b><i>Purpose:</i></b> To identify the genetic variants of the vascular endothelial growth factor (VEGF) pathway genes and other genes associated with neovascular age-related macular degeneration (nAMD) as possible predictive biomarkers of a favorable treatment response to aflibercept. <b><i>Design:</i></b> A 52-week (with extension phase: 104-week), prospective, open-label, single-arm, multicenter, phase IV trial was conducted in Spain. <b><i>Participants:</i></b> Patients with nAMD were enrolled. <b><i>Method

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Hasanah, Tita, Hana Lestari, Samsul Huda, Rusdiono Rusdiono, Lina Najwatur Rusdi, and Habibah Habibah. "Independence of Preschool Children in Tenjolaya District Bogor Regency." Proceeding of the International Conference on Multidisciplinary Research for Sustainable Innovation 1 (August 12, 2024): 300–308. http://dx.doi.org/10.31098/icmrsi.v1i.811.

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Independence in preschool children is the child's ability to regulate their thoughts and feelings so that they can do things themselves without help from others according to their stage of development. A child must grow in his independent abilities so that he can complete his developmental tasks to be able to move on to the stages of adolescence and adulthood. The aim of this research is to provide a systematic description of the independence of preschool-age children in Tenjolaya District, Bogor Regency. This research is quantitative research with research subjects of 80 mothers who have kind

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Rachma Yayank Moeztamy, Ardhia Deasy Rosita Dewi, and Yayon Pamula Mukti. "Pendugaan Umur Simpan Roti Sourdough Bekatul Menggunakan Metode ASLT dengan Pendekatan Arrhenius." Keluwih: Jurnal Sains dan Teknologi 4, no. 2 (2023): 8–15. http://dx.doi.org/10.24123/saintek.v4i2.5693.

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Abstract—Sourdough bread is a type of bread made with sourdough containing a consortium of Lactobacillus spp bacteria and yeast from the fermentation of flour and water for approximately 7 days. Rice bran sourdough bread was chosen because of its nutritional content, namely protein, fat, carbohydrates, crude fiber, calories and is rich in B vitamins, especially vitamin B1 (thiamin). Rice bran sourdough bread is a functional bakery product that is expected to have a longer shelf life than bread in general. The aim of this research is to determine the shelf life of bran sourdough bread with vari

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Tran, TS Paul, S. Victor Feinman, and Barnet Berris. "Liver Cirrhosis: A Seven Year Follow-Up." Canadian Journal of Gastroenterology 5, no. 1 (1991): 11–14. http://dx.doi.org/10.1155/1991/491483.

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The status of 121 patients who were found to have liver cirrhosis on liver biopsy in 1981 was assessed seven years later. The etiology of the cirrhosis was alcoholic in 52%, cryptogenic in 29.8%, hepatitis B-related in 9.1% and miscellaneous in 9.1%. In 1981, jaundice was present in 55 patients (45.8%), ascites in 52 (43%), gastrointestinal bleeding in 25 (20.7%) and encephalopathy in 10 (8.3%). During the following seven years an additional 20 patients developed ascites, 15 gastrointestinal bleeding, 32 encephalopathy and three hepatocellular carcinoma. The mortality race was 43.8% at five ye

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Huang, Qiang, Yongxing Cao, Chonglin Yang, Xingchen Li, Yangbo Xu, and Xiangyang Xu. "Diagnosis of tibiofibular syndesmosis instability in Weber type B malleolar fractures." Journal of International Medical Research 48, no. 7 (2020): 030006052093975. http://dx.doi.org/10.1177/0300060520939752.

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Objective This study was performed to analyze the clinical value of X-ray, computed tomography (CT), and magnetic resonance imaging (MRI) examinations for the diagnosis of distal tibiofibular syndesmosis injuries in Weber type B ankle fractures with reference to the ankle arthroscopic findings. Methods This retrospective clinical study involved 52 patients with type B ankle fractures from August 2014 to January 2018. We analyzed the patients’ preoperative imaging data and judged the stability of the distal tibiofibular syndesmosis using X-ray, CT, and MRI examinations. We also evaluated the sy

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Belo, Marcela Patricia Macêdo, Roberta Albuquerque Mello de Castro Silva, Isis Larissa Maia Nogueira, Daniele Pereira Mizoguti, and Claudiane Maria Urbano Ventura. "Conhecimento de enfermeiros de Neonatologia acerca do Cateter Venoso Central de Inserção Periférica." Revista Brasileira de Enfermagem 65, no. 1 (2012): 42–48. http://dx.doi.org/10.1590/s0034-71672012000100006.

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O Cateter Central de Inserção Periférica (PICC) vem sendo utilizado como acesso venoso seguro para neonatos de risco. Objetivou-se descrever o conhecimento e prática dos enfermeiros das cinco unidades públicas de Terapia Intensiva Neonatal, de Recife-PE, sobre a utilização do PICC. A amostra foi composta por 52 enfermeiros; os dados foram coletados de janeiro a fevereiro de 2010. Nos resultados verificou-se que 64,8% dos enfermeiros não possuíam habilitação para inserção do PICC. Apenas duas unidades utilizavam o PICC rotineiramente. Sobre a indicação desse acesso, houve nível de acerto acima

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Ueno, Masanobu, Shingo Nakayamada, Ippei Miyagawa, et al. "EFFICACY AND SAFETY OF RITUXIMAB (RTX) IN REFRACTORY LUPUS NEPHRITIS (LN) FROM REAL-WORLD LOOPS REGISTRY." Journal of Rheumatology 52, Suppl 1 (2025): 36.1–36. https://doi.org/10.3899/jrheum.2025-0390.o039.

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O039 / #695Topic:AS15 - Lupus Nephritis-ClinicalABSTRACT CONCURRENT SESSION 06: LUPUS NEPHRITIS – CLINICAL OUTCOMES, PREDICTION AND THERAPY23-05-2025 1:40 PM - 2:40 PMBackground/PurposeIn 2023, Rituximab (RTX) therapy for lupus nephritis was approved in Japan. However, the efficacy and safety in real-world clinical practice have not been validated. This study aimed to assess the efficacy and safety of RTX for LN in real-world clinical practice.MethodsPatients with LN who received remission induction therapy with high- or moderate-dose GC or GC pulse, combined with HCQ+RTX (RTX group, n=33), +M

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Barrientos, Jacqueline Claudia, Richard R. Furman, John Leonard та ін. "Update on a phase I study of the selective PI3Kδ inhibitor idelalisib (GS-1101) in combination with rituximab and/or bendamustine in patients with relapsed or refractory CLL." Journal of Clinical Oncology 31, № 15_suppl (2013): 7017. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.7017.

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7017 Background: PI3K-delta signaling is critical for proliferation, survival, homing and tissue retention of malignant B cells. Idelalisib is a first-in-class, selective, oral inhibitor of PI3Kδ that has shown considerable monotherapy activity in pts with heavily pretreated CLL. Methods: This phase I study evaluated idelalisib continuously given at 150 mg BID in combination with rituximab (R, 375 mg/m2 every wk x 8), bendamustine (B, 70 or 90 mg/m2 x 2, every 4 wks x 6) or BR (every 4 wks x 6) for relapsed/refractory CLL. Pts still on treatment after 48 weeks were eligible to continue idelali

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Li, Bin, Stephen Asche, Robert Yang, Bevan Yueh, and Manuela Fina. "Outcomes of Adopting Endoscopic Tympanoplasty in an Academic Teaching Hospital." Annals of Otology, Rhinology & Laryngology 128, no. 6 (2019): 548–55. http://dx.doi.org/10.1177/0003489419830424.

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Objectives: To compare the outcomes of endoscopic versus microscopic tympanoplasty during the initial period of a surgeon adopting the new endoscopic technique and teaching the surgical approach to residents assisting in surgery. Methods: Retrospective medical chart review of 60 consecutive operations for repair of isolated tympanic membrane perforations from 2011 to 2016 performed by a single surgeon assisted by residents in an academic teaching hospital. The outcomes of 20 ears repaired microscopically before the senior author adopted endoscopic ear surgery (Group A) were compared with the o

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Cerni, Jessica, Joel Rhee, and Hassan Hosseinzadeh. "End-of-life palliative care resource utilization in cancer care: A focus on the urban-rural continuum." Journal of Clinical Oncology 37, no. 31_suppl (2019): 52. http://dx.doi.org/10.1200/jco.2019.37.31_suppl.52.

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52 Background: Despite the advances in end-of-life cancer care, disparities exist in the availability, accessibility and use of palliative care services across the urban-rural continuum. This review explores this disparity by synthesising retrospective quantitative studies on palliative care patterns of resource use for adults during end-of-life cancer care. Methods: Five databases were searched and data analysed using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Inclusion criteria involved; a) original research; b) quantitative studies; c) English-la

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Norasetthada, Lalita, Weerasak Nawarawong, Arnuparp Lekhakula, et al. "Consolidation Radiotherapy Improved Survival in Limited Stage Diffuse Large B-Cell Lymphoma (DLBCL): A Nationwide Multi-Institutional Registry of 816 Cases in Thailand." Blood 126, no. 23 (2015): 2712. http://dx.doi.org/10.1182/blood.v126.23.2712.2712.

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Abstract Introduction The additional benefit of consolidation radiotherapy (RT) following chemotherapy in limited stage DLBCL remains controversial. Previous 5 randomized trials, 4 trials before rituximab era (SWOG 8736, ECOG 1484, GELA 93-1 and 93-4 studies) and 1 trial with R-CHOP combination (Lysa/Goelams 02-03), could not demonstrate a remarkable benefit of RT. The purpose of this study is to explore the benefit of combined modality treatment including the combination of RT and rituximab (R)-based chemotherapy in limited stage DLBCL. Methods From the 4,371 patients in a multi-institutional

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KHAN, A., M. ZARIN, and KHADEEJA. "COMPARISON OF BOTULINUM TOXIN VS LATERAL SPHINCTEROTOMY FOR THE TREATMENT OF CHRONIC ANAL FISSURE." Biological and Clinical Sciences Research Journal 2024, no. 1 (2024): 901. http://dx.doi.org/10.54112/bcsrj.v2024i1.901.

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Chronic anal fissure is a distressing condition characterized by a tear or ulcer in the lining of the anal canal. Objectives: The primary aim of this study is to compare the effectiveness of botulinum toxin versus lateral sphincterotomy in the treatment of chronic anal fissures. Methods: This comparative study was conducted at Khyber Teaching Hospital, Peshawar, from 13th August 2023 to 3rd December 2023. Data were collected from 278 patients diagnosed with chronic anal fissure, retrospectively extracted from electronic medical records. A total of 268 patients were included in the analysis, wi

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Mazar, Adil, Naceur Jemaa, Waleed Wafa Al Dajani, Mariya Marinova, and Michel Perrier. "Optimization of Lignin Recovery from the Pre-Hydrolysate of Kraft-Based Dissolving Pulp Production Processes." Applied Sciences 11, no. 1 (2021): 454. http://dx.doi.org/10.3390/app11010454.

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A pre-hydrolysate is an aqueous stream obtained during the production of hardwood kraft dissolving pulp. It is rich in sugars and contains dissolved organic matters. The purpose of this study is to investigate the optimization of lignin recovery from wood pre-hydrolysates and to characterize the extracted lignin. The optimal conditions for lignin extraction have been determined to be (a) a filtration temperature of 40 °C, (b) a sulfuric acid concentration of 8.5 kg·m−3, and (c) a coagulation time of 180 min. Using these conditions, high filtration rates have been obtained and the extracted lig

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Ecin, Seval Müzeyyen, Nursel Çalık Başaran, and Murat Aladağ. "Evaluation of the Effectiveness of Tenofovir in Chronic Hepatitis B Patients." Acta Medica 51, no. 1 (2020): 9–14. http://dx.doi.org/10.32552/0.actamedica.423.

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Introductıon: HBV infection is a global public health problem. Tenofovir disoproxil fumarate (TDF) and tenofovir alafenamide (TAF) are nucleotide reverse transcriptase inhibitors (NRTIs) that are used for the treatment of CHB infection. The aim of this study was to evaluate the treatment response and efficacy of TDF, which was a new treatment regimen in Turkey Materials and Methods: This descriptive, retrospective study was conducted between January 2009 and January 2011 at Inonu University Faculty, Turgut Ozal Medicine Center, Department of Internal Medicine, Division of Hepatology Outpatient

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Baraliakos, X., A. Deodhar, S. Liu Leage, et al. "AB0471 PATIENTS WITH RADIOGRAPHIC axSpA WHO PROGRESSED FROM ASAS20 AT WEEK 16 TO ASAS40 AT WEEK 52: RESULTS FROM COAST-W." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1262.2–1263. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1823.

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Background:The timeframe for maximum treatment response varies across patients with radiographic axial spondyloarthritis (r-axSpA). Understanding which patients may benefit from additional time on treatment could influence treatment decisions.Objectives:This post-hoc analysis aims to determine the percentage of patients, previously exposed to TNFi, who progressed from ASAS20 at week 16 to ASAS40 response at week 52 with ixekizumab (IXE) treatment and to explore factors that may associate with additional improvement after 16 weeks.Methods:Patients who achieved Assessment of SpondyloArthritis In

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Jabbour, Salma K., Ki Hyeong Lee, Nicolaj Frost, et al. "Phase II study of pembrolizumab (pembro) plus platinum doublet chemotherapy and radiotherapy as first-line therapy for unresectable, locally advanced stage III NSCLC: KEYNOTE-799." Journal of Clinical Oncology 38, no. 15_suppl (2020): 9008. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.9008.

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9008 Background: KEYNOTE-799 (NCT03631784) evaluates pembro plus concurrent chemoradiation therapy (CCRT) in pts with unresectable, locally advanced stage III NSCLC. Methods: In this phase 2, nonrandomized, open-label trial, pts with previously untreated, unresectable, pathologically confirmed stage IIIA–C NSCLC with measurable disease (RECIST 1.1) received up to 17 cycles of pembro 200 mg Q3W starting with cycle 1 plus standard thoracic radiotherapy (60 Gy in 30 daily 2-Gy fractions) in cycles 2–3 and investigator’s choice of paclitaxel 200 mg/m2 + carboplatin AUC 6 Q3W for cycle 1, then pacl

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Ravaud, Alain, Carlos H. Barrios, Boris Y. Alekseev та ін. "Randomized phase II study of first-line everolimus plus bevacizumab (E+B) versus interferon α-2a plus bevacizumab (I+B) in patients (pts) with metastatic renal cell carcinoma (mRCC): Record-2 final overall survival (OS) and safety results." Journal of Clinical Oncology 31, № 15_suppl (2013): 4576. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.4576.

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4576 Background: RECORD-2 (NCT00719264) primary analysis demonstrated similar median progression-free survival (PFS) for pts with mRCC treated with E+B and I+B (Dec 2011 cut-off). The primary objective was not met; median PFS in E+B/I+B was 9.3/10.0 mo (HRIFN/EVE, 0.91; 95% CI, 0.69-1.19; P=0.485) and probability of success (PoS) of a subsequent phase III trial was 5.1%. Here we present final OS and safety/exposure results (Aug 2012 cut-off). Methods: Untreated pts with clear cell mRCC and previous nephrectomy were randomized 1:1 to B 10 mg/kg every 2 weeks and either E 10 mg/day or I (9 MIU 3

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Gibson, M. D., J. Haelssig, J. R. Pierce, et al. "A comparison of four receptor models used to quantify the boreal wildfire smoke contribution to surface PM<sub>2.5</sub> in Halifax, Nova Scotia during the BORTAS-B experiment." Atmospheric Chemistry and Physics 15, no. 2 (2015): 815–27. http://dx.doi.org/10.5194/acp-15-815-2015.

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Abstract. This paper presents a quantitative comparison of the four most commonly used receptor models, namely absolute principal component scores (APCS), pragmatic mass closure (PMC), chemical mass balance (CMB) and positive matrix factorization (PMF). The models were used to predict the contributions of a wide variety of sources to PM2.5 mass in Halifax, Nova Scotia during the experiment to quantify the impact of BOReal forest fires on Tropospheric oxidants over the Atlantic using Aircraft and Satellites (BORTAS). However, particular emphasis was placed on the capacity of the models to predi

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Ainippully, Arun M., Sarath Kumar Narayanan, Vysakh C. N., Arun Preeth V., and Prathap Somnath. "Role of total leukocyte count in diagnosis of pediatric acute appendicitis: effect of antibiotic administration and duration of onset of symptoms." International Surgery Journal 5, no. 1 (2017): 296. http://dx.doi.org/10.18203/2349-2902.isj20175914.

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Background: Appendicitis is one of the most common pediatric surgical emergencies. The aim of the study is to determine the significance of total leukocyte count (TLC) in diagnosing appendicitis in the present era of rampant and injudicious antibiotic usage, and its relation to the duration of onset of symptoms.Methods: Study population consists of 148 pediatric patients who had confirmed appendicitis and underwent appendicectomy between January 2015 and December 2015. TLC was performed in all these patients as part of the routine work up. The population was categorized as: group I <24hrs,

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Cepeda, Santiago. "ITVT-06. Application of artificial intelligence and radiomics for the analysis of intraoperative ultrasound images of brain tumors." Neuro-Oncology 23, Supplement_6 (2021): vi229. http://dx.doi.org/10.1093/neuonc/noab196.918.

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Abstract BACKGROUND Intraoperative ultrasound (ioUS) images of brain tumors contain information that has not yet been exploited. The present work aims to analyze images in both B-mode and strain-elastography using techniques based on artificial intelligence and radiomics. We pretend to assess the capacity for differentiating glioblastomas (GBM) from solitary brain metastases (SBM) and also to assess the ability to predict the overall survival (OS) in GBM. METHODS We performed a retrospective analysis of patients who underwent craniotomy between March 2018 to June 2020 with GBM and SBM diagnose

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Florin-Christensen, Monica, Carlos E. Suarez, Stephen A. Hines, Guy H. Palmer, Wendy C. Brown, and Terry F. McElwain. "The Babesia bovis Merozoite Surface Antigen 2 Locus Contains Four Tandemly Arranged and Expressed Genes Encoding Immunologically Distinct Proteins." Infection and Immunity 70, no. 7 (2002): 3566–75. http://dx.doi.org/10.1128/iai.70.7.3566-3575.2002.

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ABSTRACT Members of the variable merozoite surface antigen (vmsa) gene family of Babesia bovis encode membrane proteins involved in erythrocyte invasion. In this study, we have identified and sequenced the complete 8.3-kb genomic locus containing msa-2, a member of the vmsa family, in the biologically cloned Mexico Mo7 strain. Four tandemly arranged copies of msa-2-related genes were found in the locus. The four genes, designated msa-2a1 (which corresponds to the originally described msa-2 gene), msa-2a2 , msa-2b, and msa-2c, were shown to be transcribed and expressed and encode proteins with

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Lebenthal, Justin M., Andrew Warren Hahn, Rebecca Tidwell, Krystal Zhang, and Ana Aparicio. "Outcomes, frailty status, and body composition of men with hormone-sensitive prostate cancer treated with bicalutamide and dutasteride." Journal of Clinical Oncology 42, no. 4_suppl (2024): 122. http://dx.doi.org/10.1200/jco.2024.42.4_suppl.122.

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122 Background: Prostate cancer is often a disease of the frail in which androgen withdrawal can further the risk of morbidity and mortality. This study aimed to describe a single institution experience with peripheral androgen blockade using bicalutamide and dutasteride (B+D) in men with hormone-sensitive prostate cancer (HSPC) in the context of body composition and frailty. Methods: Patients with HSPC treated with B+D at MD Anderson Cancer Center between 2010 and 2022 were retrospectively identified. Baseline and post-B+D frailty scores were calculated using the G8 geriatric score. Body comp

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Pekov, Igor V., Natalia V. Zubkova, Atali A. Agakhanov, et al. "New arsenate minerals from the Arsenatnaya fumarole, Tolbachik volcano, Kamchatka, Russia. X. Edtollite, K2NaCu5Fe3+O2(AsO4)4, and alumoedtollite, K2NaCu5AlO2(AsO4)4." Mineralogical Magazine 83, no. 4 (2018): 485–95. http://dx.doi.org/10.1180/mgm.2018.155.

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AbstractTwo new isostructural minerals edtollite K2NaCu5Fe3+O2(AsO4)4 and alumoedtollite K2NaCu5AlO2(AsO4)4 have been found in the Arsenatnaya fumarole, Second scoria cone of the Northern Breakthrough of the Great Tolbachik Fissure Eruption, Tolbachik volcano, Kamchatka, Russia. They are associated with sylvite, tenorite, dmisokolovite, shchurovskyite, johillerite, bradaczekite, and orthoclase. Edtollite forms prismatic crystals up to 0.02 mm × 0.1 mm; alumoedtollite forms long-prismatic crystals up to 0.01 mm × 0.1 mm. Both minerals have a semi-metallic lustre. Edtollite is brown–black to bla

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Ramachandran, Raja, Rudreshwar Prabakaran, Gnana Priya, et al. "Immunosuppressive Therapy in Primary Membranous Nephropathy with Compromised Renal Function." Nephron 146, no. 2 (2021): 138–45. http://dx.doi.org/10.1159/000518609.

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<b><i>Introduction:</i></b> Renal dysfunction at presentation is uncommon in primary membranous nephropathy (PMN). The data on the outcome of PMN patients with renal dysfunction at outset are scarce. The objective of the current study was to report the clinical outcomes of PMN patients with renal dysfunction. <b><i>Material and Methods:</i></b> This prospective longitudinal observational study included PMN patients (both incident and treatment resistant) with an estimated glomerular filtration rate of &#x3c;60 mL/min/1.73 m<sup>2</su

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MD, Masahiro Yasaka, Kazuo Minematsu MD, and Takenori Yamaguchi MD. "Optimal international normalized ratio (INR) in secondary prevention of stroke in non-valvular atrial fibrillation." Stroke 32, suppl_1 (2001): 378. http://dx.doi.org/10.1161/str.32.suppl_1.378-b.

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P213 [Purpose] In order to elucidate optimal international normalized ratio (INR) for secondary prevention of stroke in nonvalvular atrial fibrillation (NVAF), we evaluated risk of severe recurrent ischemic stroke and major hemorrhagic complications according to patients’ age and INR. [Methods] We analyzed data of two prospective studies, Japanese Nonvalvular Atrial Fibrillation-Embolism Secondary Prevention Cooperative Study (Stroke 2000; 31: 817) and NCVC NVAF Secondary Prevention Study to elucidate relationships of major ischemic stroke and hemorrhage with INR. In both studies, all patients

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Morcos, Michelle, Alexia Gonzalez, Héctor Alejandro Vaquera Alfaro, et al. "Bioinformatic Evaluation of Molecular Differences in HLA-B and Their Effect on Graft-Versus-Host Disease in Patients Receiving Haploidentical Hematopoietic Stem Cell Transplantation from Related Donors." Blood 144, Supplement 1 (2024): 7514. https://doi.org/10.1182/blood-2024-208823.

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Background Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) from related donors has become more accessible due to difficulties in finding matched related donors, the high cost of matched unrelated donors (MUD), and the use of post-transplant cyclophosphamide (PTcy) to reduce acute graft-versus-host disease (aGVHD). Key factors in selecting a haploidentical donor include age, gender, donor-specific antibodies, ABO blood group, and HLA mismatch degree. HLA-B is the most polymorphic locus, prompting the development of bioinformatics tools to evaluate the dissimilarity score (DS

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Vorobey, N. A., K. P. Kukol, P. P. Pukhtaievych, and S. Ya Kots. "COMPLEX INOCULATION OF SOYBEANS WITH NODULE BACTERIA BRADYRHIZOBIUM JAPONICUM AS A MEASURE TO OPTIMIZE SYMBIOTIC NITROGEN FIXATION." Agriciltural microbiology 38 (December 14, 2023): 29–39. http://dx.doi.org/10.35868/1997-3004.38.29-39.

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Objective. Establish effective mixed inoculants for soybeans based on new active strains of Bradyrhizobium japonicum with different intensity and dynamics of nitrogen-fixing activity to improve nodulation processes and functional activity of legume-rhizobia symbiosis. Methods. Microbiological, physiological, statistical, gas chromatography. Legume-rhizobia systems based on Glycine max L. (Merill) soybean, variety Samorodok, were studied using recombinant strains of B. japonicum: B199, B201, Д47, Д48, Д52, Д60, Д63. Monoinoculation of soybean with B. japonicum 634б served as the control. Result

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Duan, Wenbing, Xiaohong Liu, Jinsong JIA, et al. "Both the Subtypes of Kit Mutation and Minimal Residual Disease Are Associated with Prognosis in Core Banding Factor Acute Myeloid Leukemia." Blood 136, Supplement 1 (2020): 4–5. http://dx.doi.org/10.1182/blood-2020-141905.

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B ackground: No consensus has been reached on the relationship between kit mutation and prognosis in core banding factor acute myeloid leukemia(CBF-AML). Our preverious analysis of kit mutation subtypes in patients with RUNX1-RUNX1T1 suggested poor prognosis associated with D816/D820 mutation. Objective: To investigate further risk stratification according to different subtypes of kit mutations and minimal residual disease (MRD) in CBF-AML. Methods: A total of 205 patients aged 16-70 years old with CBF-AML, who were diagnosed in our hospital, were analyzed retrospectively from January 2014 to

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Yeo, W., F. K. Mo, E. P. Hui, et al. "Does severity of underlying chronic liver disease (CLD) affect treatment outcome of hepatocellular carcinoma (HCC) patients undergoing systemic chemotherapy (CT)?" Journal of Clinical Oncology 27, no. 15_suppl (2009): e15513-e15513. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.e15513.

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e15513 Background: HCC is a common cause of morbidity and mortality. CT has been one of the treatments offered to patients (pts) who are not candidate of curative surgery. Treatment of HCC could be complicated by underlying CLD. In this study, we aimed to assess pre-CT severity of CLD on treatment outcome of HCC pts who were entered into our previously reported phase III prospective randomized CT study (J Natl Cancer Inst 2005). Methods: The severity of CLD for each pt was arbitrary assessed by adopting the Child-Pugh's classification. Patients’ characteristics were compared. Treatment outcome

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Cheng, Isaac, Ho So, Carson CY Yip, et al. "Abstract 16 — Are We Treating-to-Target on Spondyloarthritis (SpA)? A One-Year Analysis from the Asia Pacific League of Associations for Rheumatology (APLAR) SpA Registry." Journal of Clinical Rheumatology and Immunology 23, Supp01 (2023): 38–40. http://dx.doi.org/10.1142/s2661341723740322.

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Background This analysis aimed to evaluate the extent of treat-to-target (T2T) achievement after 1-year intensive treatment in patients enrolled to the APLAR SpA registry. Methods Patients who fulfilled the CASPAR2006 for psoriatic arthritis (PsA), and 2009ASAS criteria for axial spondylitis (AxSpA) were recruited. Current analysis included the first 143 patients reaching the 1-year timepoint across 7 Asia-Pacific regions (Hong Kong, Singapore, Korea, India, Pakistan, Qatar and Thailand). Results 79 patients with PsA(age: 52±13 years, 43(55%) male, disease duration: 8.0±8.3 years) and 64 patie

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Prange, Anna, Beate Bokhof, Philipp Polzer, et al. "Höhere Detektionsraten biologisch aggressiver Mammakarzinome im Mammografie-Screening als im 2-jährigen Intervall." Senologie - Zeitschrift für Mammadiagnostik und -therapie 16, no. 01 (2019): 45–51. http://dx.doi.org/10.1055/a-0868-8094.

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Zusammenfassung Zielsetzung Ermittlung der altersgruppenabhängigen Detektionsraten invasiver Mammakarzinome im Mammografie-Screening einschließlich des Intervalls, differenziert nach immunhistochemischer Subtypisierung als Parameter der intrinsischen Tumoraggressivität. Material und Methode Die Zielgruppe sind 50 – 69-jährige Frauen. Alle in einer Screening-Einheit während der Implementierungsphase 1/2006 – 12/2010 in Screening (Sc)-Untersuchungen und im folgenden 2-jährigen Intervall (Iv) diagnostizierten invasiven Mammakarzinome wurden anhand des Hormonrezeptorstatus (HR) und der Her2-Expres

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Montagna, Maria Teresa, Osvalda De Giglio, Christian Napoli, et al. "Adherence to Vaccination Policy among Public Health Professionals: Results of a National Survey in Italy." Vaccines 8, no. 3 (2020): 379. http://dx.doi.org/10.3390/vaccines8030379.

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Starting from 2013, the number of unvaccinated people alarmingly increased in Italy; therefore, in 2017 a new Vaccine National Plan was approved. Healthcare workers (HCWs), especially public health professionals (PHPs, i.e., workers in in the sector of hygiene and preventive medicine), have an important role in informing and promoting vaccinations. In this context, the Italian Study Group of Hospital Hygiene of the Italian Society of Hygiene, Preventive Medicine and Public Health (GISIO-SItI) conducted a national survey to assess knowledge, attitude, and practices towards recommended vaccinati

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Aslan, Alma, Alev Turker, Ayse Kars, Ibrahim Barista, and Evren Ozdemir. "Rituximab in Combination with Cyclophosphamide, Mitoxantrone, Vincristine and Prednisone (R-CNOP) As First Line Regimen in Elderly Patients with Diffuse Large B-Cell Lymphoma." Blood 128, no. 22 (2016): 5390. http://dx.doi.org/10.1182/blood.v128.22.5390.5390.

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Abstract Diffuse large B-cell lymphoma (DLBCL) is a treatable and potentially curable malignancy that is increasing in prevalence in the elderly. Because of geriatric considerations including functional status and comorbidities and increased toxicity concerns, older patients are sometimes given reduced dose therapy. Mitoxantrone has a broad anti-tumour activity including lymphoma with potentially less cardiotoxicity than doxorubicin, which may be of particular importance in the treatment of elderly aggressive lymphoma patients. This study's objective was to evaluate the efficacy and safety of

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Popov, A. F., S. L. Kolpakov, V. A. Ivanis, N. S. Tumanova, and G. N. Bondar. "EPIDEMIOLOGICAL FEATURES OF ENTEROVIRUS MENINGITIS IN THE RUSSIAN FAR EAST." Vestnik of North-Eastern Federal University. Medical Sciences, no. 4 (January 8, 2025): 52–59. https://doi.org/10.25587/2587-5590-2024-4-52-59.

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The article presents data on the prevalence of enterovirus meningitis in the Far Eastern Federal District for the period from 2010 to 2023. Enterovirus meningitis was registered in all territories of the Far Eastern Federal District. The maximum incidence rates were detected in Khabarovsk Krai. The maximum indicators for Khabarovsk Krai, statistically exceeding all subjects of the Far Eastern Federal District, are probably the result of effective laboratory diagnostics, and not the presence of additional risk factors for the development of the epidemic process. Sakhalin Oblast ranked second, f

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Kindler, H. L., D. Niedzwiecki, D. Hollis, et al. "A double-blind, placebo-controlled, randomized phase III trial of gemcitabine (G) plus bevacizumab (B) versus gemcitabine plus placebo (P) in patients (pts) with advanced pancreatic cancer (PC): A preliminary analysis of Cancer and Leukemia Group B (CALGB." Journal of Clinical Oncology 25, no. 18_suppl (2007): 4508. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.4508.

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4508 Background: In a phase II trial in 52 PC pts, GB yielded a 21% response rate and a median survival of 8.8 months (mo) (Kindler, JCO 2005). These data led CALGB to conduct a phase III trial of GB vs. GP in advanced PC pts. Methods: This randomized trial was double-blind, placebo-controlled. Eligible pts had no prior therapy for advanced disease, PS 0–2, no tumor invasion of adjacent organs, no increased bleeding risk. Primary endpoint: overall survival (OS). Stratification: PS (0/1 or 2), disease extent (locally advanced or metastatic), prior radiation (RT) (yes/no). Statistics: 90% power

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Arslantürk Güneysu, C., D. Karatas, N. Erdik, et al. "AB0666 THE RELATIONSHIP BETWEEN NEUROPATHIC PAIN AND AUTOANTIBODY POSITIVITY AND SALIVARY GLAND BIOPSY IN PATIENTS WITH PRIMARY SJÖGREN’S SYNDROME." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1535.3–1535. http://dx.doi.org/10.1136/annrheumdis-2023-eular.2175.

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BackgroundSjögren’s syndrome (SjS) is an autoimmune disease characterized by exocrine gland inflammation (1). Extraglandular manifestations are common in SjS. Some articles reported neuropathic pain in 40% of patients with SjS (2). Autoantibodies (SS-A, SS-B, Anti Ro-52) and salivary gland biopsy are used to diagnose SjS. The relationship between autoantibody, salivary gland biopsy results, and neurological involvement is unclear.ObjectivesIn this study, autoantibody positivity and salivary gland biopsy results were compared with the frequency of neuropathic pain.MethodsPatients with a diagnos

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Gumprecht, Jakub, Magdalena Domek, Marco Proietti, et al. "Compliance of Atrial Fibrillation Treatment with the Atrial Fibrillation Better Care (ABC) Pathway Improves the Clinical Outcomes in the Middle East Population: A Report from the Gulf Survey of Atrial Fibrillation Events (SAFE) Registry." Journal of Clinical Medicine 9, no. 5 (2020): 1286. http://dx.doi.org/10.3390/jcm9051286.

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Atrial fibrillation (AF) is associated with substantially increased risk of cardiovascular events and overall mortality. The Atrial fibrillation Better Care (A—Avoid stroke, B—Better symptom management, C—Cardiovascular and comorbidity risk management) pathway provides a simple and comprehensive approach for integrated AF therapy. This study’s goals were to evaluate the ABC pathway compliance and determine the main gaps in AF management in the Middle East population, and to assess the impact of ABC pathway adherence on the all-cause mortality and composite outcome in AF patients. 2021 patients

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Gómez Martín, Fernando. "Convenio y liquidación concursal." Estudios de Deusto 52, no. 1 (2013): 129. http://dx.doi.org/10.18543/ed-52(1)-2004pp129-264.

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Sumario: 1. Fase de convenio. 1.1. Antecedentes prelegislativos. 2. El convenio. 2.1. Naturaleza jurídica. 2.2. Contenido del convenio. 3. Propuestas de convenio. 3.1. Evaluación de las propuestas de convenio. 3.1.1. Cumplimiento de requisitos generales. 3.1.2. Examen del plan de pagos. 3.1.3. Examen del plan de viabilidad. 3.2. Propuesta anticipada de convenio. 3.2.1. Plazo de presentación y contenido. 3.2.2. Prohibiciones. 3.2.3. Admisión a trámite. 3.2.4. Adhesión de acreedores. 3.2.5. Aprobación judicial de convenio anticipado. 3.3. Propuestas de convenio para junta. 3.3.1. Presentación y

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YADAV, RAKESH KUMAR, NARENDRA KUMAWAT, A. SINGH, et al. "Bio-efficacy of new herbicides on weed dynamics, productivity and nutrient uptake in maize (Zea mays) under rainfed condition of Jhabua hills." Indian Journal of Agricultural Sciences 88, no. 7 (2018): 1123–28. http://dx.doi.org/10.56093/ijas.v88i7.81599.

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Field studies were conducted during the rainy seasons of 2014 and 2015 at Zonal Agricultural Research Station, Jhabua under the rainfed condition to determine the effect of new herbicides on weed dynamic, yield and nutrient uptake in maize (Zea mays L.). Results revealed that application of saflufenacil 68 g/l + diamethanamid-P 600 g/l EC (85 +750 g/ha) recorded the lowest weed density of sedges, grasses and broad leaf weeds in maize, and improved growth, yield attributes and yield of maize. The highest grain yield (3.37 t/ha), stover yield (4.17 t/ha) and biological yield (7.57 t/ha) was reco

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Barcellini, Wilma, Francesca Guia Imperiali, Anna Zaninoni, et al. "Expression of TLRs in B-CLL: Relationship with Disease Activity." Blood 118, no. 21 (2011): 4597. http://dx.doi.org/10.1182/blood.v118.21.4597.4597.

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Abstract Abstract 4597 Toll-like receptors (TLRs) are major agents of innate immunity and initiators of adaptive immune response by acting as costimulatory signals for B cells and inducing maturation, proliferation and antibody production after pathogen recognition. They are also involved in the self-antigen recognition and could play a role in autoimmune phenomena. It is well established that B-chronic lymphocytic leukemia (B-CLL) is characterized by an increased incidence of autoimmune phenomena and immunodeficiency, which can greatly influence the disease outcome leading to a variable clini

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Oluwole, Olalekan O., Armin Ghobadi, Ryan Daniel Cassaday, et al. "Long-term survival outcomes of patients (pts) with relapsed or refractory B-cell acute lymphoblastic leukemia (R/R B-ALL) treated with brexucabtagene autoleucel (brexu-cel) in ZUMA-3." Journal of Clinical Oncology 42, no. 16_suppl (2024): 6531. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.6531.

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6531 Background: Brexu-cel is an autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy approved for pts ≥18 y with R/R B-ALL in the US (≥26 y in the EU). In the 3-y follow-up of ZUMA-3, median overall survival (OS) was 25.6 mo (N=78). Survival benefit was seen regardless of age, prior treatment, or subsequent allogeneic stem cell transplant (sub alloSCT) status (Shah et al. ASCO 2023. #7023). Here we report 4-y survival outcomes for ZUMA-3. Methods: Eligible pts (≥18 y) had R/R B-ALL and received brexu-cel (1×106 CAR T cells/kg) after leukapheresis and lymphodepleting chemotherap

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