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Zeitschriftenartikel zum Thema „ACE100“

Autor: Grafiati

Veröffentlicht am 28. Juni 2021

Zuletzt aktualisiert am 29. Juli 2025

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1

Liang, Yan, Peter Melchior, Sicong Lu, Andy Goulding, and Charlotte Ward. "Autoencoding Galaxy Spectra. II. Redshift Invariance and Outlier Detection." Astronomical Journal 166, no. 2 (2023): 75. http://dx.doi.org/10.3847/1538-3881/ace100.

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Abstract We present an unsupervised outlier detection method for galaxy spectra based on the spectrum autoencoder architecture spender, which reliably captures spectral features and provides highly realistic reconstructions for SDSS galaxy spectra. We interpret the sample density in the autoencoder latent space as a probability distribution, and identify outliers as low-probability objects with a normalizing flow. However, we found that the latent-space position is not, as expected from the architecture, redshift invariant, which introduces stochasticity into the latent space and the outlier d

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Mu, Jichong, Jihong Ouyang, Yachen Yao, and Zongxiao Ren. "Span-Prototype Graph Based on Graph Attention Network for Nested Named Entity Recognition." Electronics 12, no. 23 (2023): 4753. http://dx.doi.org/10.3390/electronics12234753.

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Named entity recognition, a fundamental task in natural language processing, faces challenges related to the sequence labeling framework widely used when dealing with nested entities. The span-based method transforms nested named entity recognition into span classification tasks, which makes it an efficient way to deal with overlapping entities. However, too much overlap among spans may confuse the model, leading to inaccurate classification performance. Moreover, the entity mentioned in the training dataset contains rich information about entities, which are not fully utilized. So, in this pa

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Guo, Yunqiao, Tinglong Tang, Shuifa Sun, Yirong Wu, and Xiaolong Li. "Nested Entity Recognition Fusing Span Relative Position and Region Information." Electronics 12, no. 11 (2023): 2483. http://dx.doi.org/10.3390/electronics12112483.

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At present, span-based entity recognition methods are mainly used to accurately identify the span (entity) boundary for entity recognition, in which the relative position information of the span boundary and the information of words in the span region are routinely ignored. This information can be used to improve entity recognition performance. Therefore, a nested entity recognition model, which integrates the relative position information of the span and the region information within the span, is proposed. The span representation is first obtained with a triaffine attention. Then, the relativ

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Shen, Chang-Hui, Benoit P. Leblanc, Jennifer A. Alfieri, and David J. Clark. "Remodeling of Yeast CUP1 Chromatin Involves Activator-Dependent Repositioning of Nucleosomes over the Entire Gene and Flanking Sequences." Molecular and Cellular Biology 21, no. 2 (2001): 534–47. http://dx.doi.org/10.1128/mcb.21.2.534-547.2001.

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ABSTRACT The yeast CUP1 gene is activated by the copper-dependent binding of the transcriptional activator, Ace1p. An episome containing transcriptionally active or inactiveCUP1 was purified in its native chromatin structure from yeast cells. The amount of RNA polymerase II on CUP1 in the purified episomes correlated with its transcriptional activity in vivo. Chromatin structures were examined by using the monomer extension technique to map translational positions of nucleosomes. The chromatin structure of an episome containing inactive CUP1 isolated from ace1Δ cells is organized into clusters

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Koronyo-Hamaoui, Maya, Julia Sheyn, Eric Y. Hayden, et al. "Peripherally derived angiotensin converting enzyme-enhanced macrophages alleviate Alzheimer-related disease." Brain 143, no. 1 (2019): 336–58. http://dx.doi.org/10.1093/brain/awz364.

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Abstract Targeted overexpression of angiotensin-converting enzyme (ACE), an amyloid-β protein degrading enzyme, to brain resident microglia and peripheral myelomonocytes (ACE10 model) substantially diminished Alzheimer’s-like disease in double-transgenic APPSWE/PS1ΔE9 (AD+) mice. In this study, we explored the impact of selective and transient angiotensin-converting enzyme overexpression on macrophage behaviour and the relative contribution of bone marrow-derived ACE10 macrophages, but not microglia, in attenuating disease progression. To this end, two in vivo approaches were applied in AD+ mi

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Li, Xiang, Junan Yang, Hui Liu, and Pengjiang Hu. "HTLinker: A Head-to-Tail Linker for Nested Named Entity Recognition." Symmetry 13, no. 9 (2021): 1596. http://dx.doi.org/10.3390/sym13091596.

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Named entity recognition (NER) aims to extract entities from unstructured text, and a nested structure often exists between entities. However, most previous studies paid more attention to flair named entity recognition while ignoring nested entities. The importance of words in the text should vary for different entity categories. In this paper, we propose a head-to-tail linker for nested NER. The proposed model exploits the extracted entity head as conditional information to locate the corresponding entity tails under different entity categories. This strategy takes part of the symmetric bound

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Dong, Jiayin, and Daniel Foreman-Mackey. "A Hierarchical Bayesian Framework for Inferring the Stellar Obliquity Distribution." Astronomical Journal 166, no. 3 (2023): 112. http://dx.doi.org/10.3847/1538-3881/ace105.

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Abstract Stellar obliquity, the angle between a planet’s orbital axis and its host star’s spin axis, traces the formation and evolution of a planetary system. In transiting-exoplanet observations, only the sky-projected stellar obliquity can be measured, but this can be deprojected using an estimate of the stellar obliquity. In this paper, we introduce a flexible, hierarchical Bayesian framework that can be used to infer the stellar obliquity distribution solely from sky-projected stellar obliquities, including stellar inclination measurements when available. We demonstrate that while a constr

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Schouws, Sander, Rychard Bouwens, Renske Smit, et al. "ALMA as a Redshift Machine: Using [C ii] to Efficiently Confirm Galaxies in the Epoch of Reionization." Astrophysical Journal 954, no. 1 (2023): 103. http://dx.doi.org/10.3847/1538-4357/ace10c.

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Abstract The [C ii]158μm line has long been proposed as a promising line to spectroscopically confirm galaxies in the epoch of reionization. In this paper, we present the results of new ALMA observations spectral scanning for [C ii] in six particularly luminous Lyman-break galaxies at z ∼ 7. The six sources were drawn from a sample of bright z ∼ 7 galaxies identified using the wide-area optical, near-IR, and Spitzer/IRAC data over the COSMOS/UltraVISTA field and were targeted on the basis of tight constraints on their redshifts from their IRAC [3.6]–[4.5] colors. We detect significant (>9σ)

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Shang 尚, ZiQian 自乾, Zhao 昭. Wu 武, Yan 岩. Liu 刘, et al. "The Calibration of the 35–40 GHz Solar Radio Spectrometer with the New Moon and a Noise Source." Astrophysical Journal Supplement Series 268, no. 2 (2023): 45. http://dx.doi.org/10.3847/1538-4365/acee00.

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Abstract Calibrating solar radio flux has always been a concern in the solar community. Previously, fluxes were calibrated by matching load or the new Moon for relative calibration, and at times with the assistance of other stations’ data. Moreover, the frequency coverage seldom exceeded 26 GHz. This paper reports the upgraded and calibrated Chashan Broadband Solar millimeter spectrometer (CBS) working from 35 to 40 GHz at the Chashan Solar Observatory (CSO). Initially, the calibration of the solar radiation brightness temperature is accomplished using the new Moon as the definitive source. Su

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Jackson, Brian, Elisabeth R. Adams, and Jeffrey P. Morgenthaler. "Metrics for Optimizing Searches for Tidally Decaying Exoplanets." Astronomical Journal 166, no. 4 (2023): 142. http://dx.doi.org/10.3847/1538-3881/acef00.

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Abstract Tidal interactions between short-period exoplanets and their host stars drive orbital decay and have likely led to engulfment of planets by their stars. Precise transit timing surveys, with baselines now spanning decades for some planets, are directly detecting orbital decay for a handful of planets, with corroboration for planetary engulfment coming from independent lines of evidence. More than that, recent observations have perhaps even caught the moment of engulfment for one unfortunate planet. These portentous signs bolster prospects for ongoing surveys, but optimizing such a surv

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Teklu, Adelheid, Rolf-Peter Kudritzki, Klaus Dolag, Rhea-Silvia Remus, and Lucas Kimmig. "On the Decline of Star Formation during the Evolution of Galaxies." Astrophysical Journal 954, no. 2 (2023): 182. http://dx.doi.org/10.3847/1538-4357/ace900.

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Abstract Cosmological simulations predict that during the evolution of galaxies, the specific star formation rate continuously decreases. In a previous study we showed that generally this is not caused by the galaxies running out of cold gas but rather a decrease in the fraction of gas capable of forming stars. To investigate the origin of this behavior, we use disk galaxies selected from the cosmological hydrodynamical simulation Magneticum Pathfinder and follow their evolution in time. We find that the mean density of the cold gas regions decreases with time. This is caused by the fact that

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Chae, Kyu-Hyun. "Breakdown of the Newton–Einstein Standard Gravity at Low Acceleration in Internal Dynamics of Wide Binary Stars." Astrophysical Journal 952, no. 2 (2023): 128. http://dx.doi.org/10.3847/1538-4357/ace101.

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Abstract A gravitational anomaly is found at weak gravitational acceleration g N ≲ 10−9 m s−2 from analyses of the dynamics of wide binary stars selected from the Gaia DR3 database that have accurate distances, proper motions, and reliably inferred stellar masses. Implicit high-order multiplicities are required and the multiplicity fraction is calibrated so that binary internal motions agree statistically with Newtonian dynamics at a high enough acceleration of ≈10−8 m s−2. The observed sky-projected motions and separation are deprojected to the 3D relative velocity v and separation r through

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Zheng, Dong, Zhongxiang Wang, Xiao Zhang, Yang Chen, and Yi Xing. "4FGL J1844.4–0306: High-energy Emission Likely from the Supernova Remnant G29.37 + 0.1." Astrophysical Journal 952, no. 2 (2023): 158. http://dx.doi.org/10.3847/1538-4357/ace10b.

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Abstract Very-high-energy (VHE) observations have revealed approximately 100 TeV sources in our Galaxy, and a significant fraction of them are under investigation to understand their origin. We report our study of one of them, HESS J1844−030. It is found to be possibly associated with the supernova remnant (SNR) candidate G29.37 + 0.1, and detailed studies of the source region at radio and X-ray frequencies have suggested that this SNR is a composite one, containing a pulsar wind nebula (PWN) powered by a candidate young pulsar. As the GeV source 4FGL J1844.4−0306 is also located in the region

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Vitale, V., C. Neubüser, R. Battiston, et al. "Electron Signal Induced by GRB 221009A on Charged Particle Telescopes of POES and MetOp Satellites." Astrophysical Journal 952, no. 2 (2023): 159. http://dx.doi.org/10.3847/1538-4357/ace108.

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Abstract GRB 221009A is a long gamma-ray burst among the most energetic and nearest (z = 0.151) detected so far. The energy fluence of the burst was so large to cause ionization of the upper layers of Earth’s atmosphere and also observable signals in satellite-borne particle detectors. Electron signals, with the same GRB time development, can arise from the interaction of energetic photons with the particle detector and support structures. This effect was previously reported for the HEPP-L on board the China Seismo-Electromagnetic Satellite. We searched for the same effect on the particle dete

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Kempton, Eliza M. R., Madeline Lessard, Matej Malik, et al. "Where are the Water Worlds?: Self-consistent Models of Water-rich Exoplanet Atmospheres." Astrophysical Journal 953, no. 1 (2023): 57. http://dx.doi.org/10.3847/1538-4357/ace10d.

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Abstract It remains to be ascertained whether sub-Neptune exoplanets primarily possess hydrogen-rich atmospheres or whether a population of H2O-rich water worlds lurks in their midst. Addressing this question requires improved modeling of water-rich exoplanetary atmospheres, both to predict and interpret spectroscopic observations and to serve as upper boundary conditions on interior structure calculations. Here, we present new models of hydrogen-helium-water atmospheres with water abundances ranging from solar to 100% water vapor. We improve upon previous models of high-water-content atmosphe

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Veilleux, Sylvain, Weizhe Liu, Andrey Vayner, et al. "First Results from the JWST Early Release Science Program Q3D: The Warm Ionized Gas Outflow in z ∼ 1.6 Quasar XID 2028 and Its Impact on the Host Galaxy." Astrophysical Journal 953, no. 1 (2023): 56. http://dx.doi.org/10.3847/1538-4357/ace10f.

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Abstract Quasar feedback may regulate the growth of supermassive black holes, quench coeval star formation, and impact galaxy morphology and the circumgalactic medium. However, direct evidence for quasar feedback in action at the epoch of peak black hole accretion at z ≈ 2 remains elusive. A good case in point is the z = 1.6 quasar WISEA J100211.29+013706.7 (XID 2028), where past analyses of the same ground-based data have come to different conclusions. Here, we revisit this object with the integral-field unit of the Near Infrared Spectrograph on board the JWST as part of Early Release Science

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Washinoue, Haruka, and Takeru K. Suzuki. "Coronal Loops with Different Metallicities and Generalized RTV Scaling Laws." Astrophysical Journal 953, no. 1 (2023): 74. http://dx.doi.org/10.3847/1538-4357/ace106.

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Abstract Stellar metallicity is a critical factor to characterize the stellar coronae because it directly affects the radiative energy loss from the atmosphere. By extending theoretical relations for solar coronal loops introduced by Rosner et al., we analytically derive scaling relations for stellar coronal loops with various metallicities. In order to validate the derived relations, we also perform magnetohydrodynamic simulations for the heating of coronal loops with different metallicities by changing radiative-loss functions according to the adopted elemental abundances. The simulation res

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Li, Jia-Lun, Yu-Peng Yang, Shuang-Xi Yi,, Jian-Ping Hu, Fa-Yin Wang, and Yan-Kun Qu. "Constraints on the Cosmological Parameters with Three-Parameter Correlation of Gamma-Ray Bursts." Astrophysical Journal 953, no. 1 (2023): 58. http://dx.doi.org/10.3847/1538-4357/ace107.

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Abstract As one of the most energetic and brightest events, gamma-ray bursts (GRBs) can be treated as a promising probe of the high-redshift universe. Similar to type Ia supernovae, GRBs with the same physical origin could be treated as standard candles. We select GRB samples with the same physical origin, which are divided into two groups. The first group consists of 31 GRBs with a plateau phase feature of a constant luminosity followed by a decay index of about −2 in the X-ray afterglow light curves, and the second group has 50 GRBs with a shallow decay phase in the optical light curves. For

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Kenoly, Lailani, A. Ken Luu, Celia Toral, et al. "Understanding Binary Systems—a Comparison between COSMIC and MESA." Research Notes of the AAS 7, no. 8 (2023): 167. http://dx.doi.org/10.3847/2515-5172/aced00.

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Abstract We compare the evolution of binary systems evolved in the MESA stellar evolution code to those in the COSMIC population synthesis code. Our aim is to convey the robustness of the equations that model binary evolution in the COSMIC code, particularly for the cases of high mass stars with closely orbiting compact object companions. Our larger goal is to accurately model the rates of these systems, as they are promising candidates for the progenitor systems behind energetic, longer lasting, radio bright GRB jets. These systems also may be key contributors to the rates of binary black hol

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Fischer, Travis C., Megan C. Johnson, Nathan J. Secrest, D. Michael Crenshaw, and Steven B. Kraemer. "No Small-scale Radio Jets Here: Multiepoch Observations of Radio Continuum Structures in NGC 1068 with the VLBA." Astrophysical Journal 953, no. 1 (2023): 87. http://dx.doi.org/10.3847/1538-4357/ace1f0.

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Abstract We present recent Very Long Baseline Array (VLBA) 5 GHz radio observations of the nearby, luminous Seyfert 2 galaxy NGC 1068 for comparison to similar VLBA observations made on 1997 April 26. By cross-correlating the positions of emitting regions across both epochs, we find that spatially resolved extranuclear radio knots in this system have subrelativistic transverse speeds (v ≲0.1c). We discuss sources of the observed knots and how the radio emission relates to additional phases of gas in the central ∼150 pc of this system. We suggest that the most likely explanation for the observe

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Kokusho, Takuma, Hiroki Torii, Hidehiro Kaneda, Yasuo Fukui, and Kengo Tachihara. "Properties of Star Formation of the Large Magellanic Cloud As Probed by Young Stellar Objects." Astrophysical Journal 953, no. 1 (2023): 104. http://dx.doi.org/10.3847/1538-4357/ace10e.

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Abstract We perform a systematic study of the evolutionary stages and stellar masses of young stellar objects (YSOs) in the Large Magellanic Cloud (LMC) to investigate the properties of star formation in the galaxy. There are 4825 sources in our YSO sample, which are constructed by combining the previous studies identifying YSOs in the LMC. Spectral energy distributions of the YSOs from optical to infrared wavelengths were fitted with a model consisting of stellar, polycyclic aromatic hydrocarbon, and dust emissions. We utilize the stellar-to-dust luminosity ratios thus derived to study the ev

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Cho, Jungyeon. "Obtaining the Strength of the Magnetic Field from E- and B-Modes of Dust Polarization." Astrophysical Journal 953, no. 1 (2023): 114. http://dx.doi.org/10.3847/1538-4357/ace10a.

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Abstract We perform numerical simulations of supersonic magnetohydrodynamic (MHD) turbulence and calculate Fourier power spectra of E- and B-modes arising from dust polarization. We pay close attention to the ratio of E-mode to B-mode spectra (a.k.a. E/B power asymmetry) on small spatial scales. We find that the ratio depends on the strength of the mean magnetic field: the stronger the mean magnetic field, the smaller the ratio. More precisely speaking, the ratio scales with the Alfvén Mach number M A , the rms velocity divided by the Alfvén speed of the mean magnetic field, when it lies in th

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Giangrandi, Edoardo, Violetta Sagun, Oleksii Ivanytskyi, Constança Providência, and Tim Dietrich. "The Effects of Self-interacting Bosonic Dark Matter on Neutron Star Properties." Astrophysical Journal 953, no. 1 (2023): 115. http://dx.doi.org/10.3847/1538-4357/ace104.

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Abstract We propose a model of asymmetric bosonic dark matter (DM) with self-repulsion. By adopting the two-fluid formalism, we study different DM distribution regimes, either, fully condensed inside the core of a star, or, otherwise, distributed in a dilute halo around a neutron star (NS). We show that for a given total gravitational mass, DM condensed in a core leads to a smaller radius and tidal deformability compared to a pure baryonic star. This effect may be interpreted as an effective softening of the equation of state. On the other hand, the presence of a DM halo increases the tidal de

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Lopez-Rodriguez, Enrique. "The Magnetic Fields of Starburst Galaxies. I. Identification and Characterization of the Thermal Polarization in the Galactic Disk and Outflow." Astrophysical Journal 953, no. 1 (2023): 113. http://dx.doi.org/10.3847/1538-4357/ace110.

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Abstract Far-infrared polarized emission by means of magnetically aligned dust grains is an excellent tracer of the magnetic fields (B-fields) in the cold phase of the galactic outflows of starburst galaxies. We present a comprehensive study of the B-fields in three nearby (3.5–17.2 Mpc) starbursts (M82, NGC 253, and NGC 2146) at 5 pc–1.5 kpc resolutions using publicly available 53–890 μm imaging polarimetric observations with Stratospheric Observatory for Infrared Astronomy/HAWC+, James Clerk Maxwell Telescope/POL-2, and ALMA. We find that the polarized spectral energy distributions (SEDs) of

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Merc, Jaroslav, Rudolf Gális, Marek Wolf, et al. "Comprehensive Analysis of a Symbiotic Candidate V503 Her." Astronomical Journal 166, no. 2 (2023): 65. http://dx.doi.org/10.3847/1538-3881/ace109.

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Abstract V503 Her was previously proposed as an eclipsing symbiotic candidate based on photometric behavior and spectroscopic appearance indicating the composite optical spectrum. To investigate its nature, we analyzed long-term photometric observations covering 100 yr of its photometric history and new low-resolution optical spectroscopic data, supplemented with the multifrequency measurements collected from several surveys and satellites. Based on the analysis presented in this paper, we claim that V503 Her is not an eclipsing binary star. The optical and infrared wavelengths are dominated b

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Keegans, James D., Marco Pignatari, Richard J. Stancliffe, et al. "Type Ia Supernova Nucleosynthesis: Metallicity-dependent Yields." Astrophysical Journal Supplement Series 268, no. 1 (2023): 8. http://dx.doi.org/10.3847/1538-4365/ace102.

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Abstract Type Ia supernova explosions (SN Ia) are fundamental sources of elements for the chemical evolution of galaxies. They efficiently produce intermediate-mass (with Z between 11 and 20) and iron group elements—for example, about 70% of the solar iron is expected to be made by SN Ia. In this work, we calculate complete abundance yields for 39 models of SN Ia explosions, based on three progenitors—a 1.4 M ⊙ deflagration detonation model, a 1.0 M ⊙ double detonation model, and a 0.8 M ⊙ double detonation model—and 13 metallicities, with 22Ne mass fractions of 0, 1 × 10−7, 1 × 10−6, 1 × 10−5

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Hintz, Dominik, Sarah Peacock, Travis Barman, et al. "Modeling the Chromosphere and Transition Region of Planet-hosting Star GJ 436." Astrophysical Journal 954, no. 1 (2023): 73. http://dx.doi.org/10.3847/1538-4357/ace103.

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Abstract Ahead of upcoming space missions intending to conduct observations of low-mass stars in the ultraviolet (UV) spectral region it becomes imperative to simultaneously conduct atmospheric modeling from the UV to the visible (VIS) and near-infrared (NIR). Investigations on extended spectral regions will help to improve the overall understanding of the diversity of spectral lines arising from very different atmospheric temperature regions. Here we investigate atmosphere models with a chromosphere and transition region for the M2.5V star GJ 436, which hosts a close-in Hot Neptune. The atmos

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Tan, Chuanqi, Wei Qiu, Mosha Chen, Rui Wang, and Fei Huang. "Boundary Enhanced Neural Span Classification for Nested Named Entity Recognition." Proceedings of the AAAI Conference on Artificial Intelligence 34, no. 05 (2020): 9016–23. http://dx.doi.org/10.1609/aaai.v34i05.6434.

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Named entity recognition (NER) is a well-studied task in natural language processing. However, the widely-used sequence labeling framework is usually difficult to detect entities with nested structures. The span-based method that can easily detect nested entities in different subsequences is naturally suitable for the nested NER problem. However, previous span-based methods have two main issues. First, classifying all subsequences is computationally expensive and very inefficient at inference. Second, the span-based methods mainly focus on learning span representations but lack of explicit bou

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Fu, Yao, Chuanqi Tan, Mosha Chen, Songfang Huang, and Fei Huang. "Nested Named Entity Recognition with Partially-Observed TreeCRFs." Proceedings of the AAAI Conference on Artificial Intelligence 35, no. 14 (2021): 12839–47. http://dx.doi.org/10.1609/aaai.v35i14.17519.

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Named entity recognition (NER) is a well-studied task in natural language processing. However, the widely-used sequence labeling framework is difficult to detect entities with nested structures. In this work, we view nested NER as constituency parsing with partially-observed trees and model it with partially-observed TreeCRFs. Specifically, we view all labeled entity spans as observed nodes in a constituency tree, and other spans as latent nodes. With the TreeCRF we achieve a uniform way to jointly model the observed and the latent nodes. To compute the probability of partial trees with partia

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Yan, Yukun, Bingling Cai, and Sen Song. "Nested Named Entity Recognition as Building Local Hypergraphs." Proceedings of the AAAI Conference on Artificial Intelligence 37, no. 11 (2023): 13878–86. http://dx.doi.org/10.1609/aaai.v37i11.26625.

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Named entity recognition is a fundamental task in natural language processing. Based on the sequence labeling paradigm for flat named entity recognition, multiple methods have been developed to handle the nested structures. However, they either require fixed recognition order or introduce complex hypergraphs. To tackle this problem, we propose a novel model named Local Hypergraph Builder Network (LHBN) that builds multiple simpler local hypergraphs to capture named entities instead of a single complex full-size hypergraph. The proposed model has three main properties: (1) The named entities th

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Ekatpure, Shubham Rajendra. "Efficient Named Entity Recognition with Overlapping and Nested Mentions Using Hypergraphs and Neural Network." INTERANTIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENT 08, no. 11 (2024): 1–7. http://dx.doi.org/10.55041/ijsrem14900.

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Abstract—Named Entity Recognition (NER) remains a pivotal task in Natural Language Processing (NLP), crucial for information extraction and document classification applications. Traditional models like linear-chain Conditional Random Fields (CRFs) struggle to handle overlapping and nested mentions, which frequently occur in specialized domainssuch as biomedical and legal texts. This study addresses these limitations by proposing an advanced model that integrates mention hypergraphs, mention separators, and neural networks to efficiently recognize complex entity structures while maintaining lin

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Sun, Weiwei, Shengquan Liu, Yan Liu, Lingqi Kong, and Zhaorui Jian. "Named Entity Recognition Networks Based on Syntactically Constrained Attention." Applied Sciences 13, no. 6 (2023): 3993. http://dx.doi.org/10.3390/app13063993.

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The task of named entity recognition can be transformed into a machine reading comprehension task by associating the query and its context, which contains entity information, with the encoding layer. In this process, the model learns a priori knowledge about the entity, from the query, to achieve good results. However, as the length of the context and query increases, the model struggles with an increasing number of less relevant words, which can distract it from the task. Although attention mechanisms can help the model understand contextual semantic relations, without explicit constraint inf

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Hartmann, Rudolf, Tjerk Feenstra, Sabine Knappe, Michael Dockal, and Friedrich Scheiflinger. "Elucidating the Excessive Pro-Coagulant Effect of a Sequence Identical Analogue to ACE910 in Combination with Bypassing Agents." Blood 130, Suppl_1 (2017): 90. http://dx.doi.org/10.1182/blood.v130.suppl_1.90.90.

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Abstract Introduction: Emicizumab (ACE910), an antibody to FIX(a) and FX(a), is currently under investigation for treatment of hemophilia with inhibitors. In a phase III trial, two thromboembolic complications and three cases of microangiopathy were reported in patients on ACE910 prophylaxis [Oldenburg et al. NEJM 2017], whose breakthrough bleeding was treated with activated prothrombin complex concentrate aPCC (FEIBA) or aPCC and rFVIIa. We generated a sequence identical analogue (SIA) to ACE910 and analyzed its synergistic interplay with bypassing agents. Aims: To monitor in vitro the pro-co

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Gao, Wenchao, Yu Li, Xiaole Guan, Shiyu Chen, and Shanshan Zhao. "Research on Named Entity Recognition Based on Multi-Task Learning and Biaffine Mechanism." Computational Intelligence and Neuroscience 2022 (August 25, 2022): 1–11. http://dx.doi.org/10.1155/2022/2687615.

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Commonly used nested entity recognition methods are span-based entity recognition methods, which focus on learning the head and tail representations of entities. This method lacks obvious boundary supervision, which leads to the failure of the correct candidate entities to be predicted, resulting in the problem of high precision and low recall. To solve the above problems, this paper proposes a named entity recognition method based on multi-task learning and biaffine mechanism, introduces the idea of multi-task learning, and divides the task into two subtasks, entity span classification and bo

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Li, Hao-Kang, Ching-Wen Hsiao, Sen-Han Yang, et al. "772 A potent and off-the-shelf oNK cell therapy product targets HER2+ cancer cells and resists suppressive tumor microenvironment." Journal for ImmunoTherapy of Cancer 8, Suppl 3 (2020): A821. http://dx.doi.org/10.1136/jitc-2020-sitc2020.0772.

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BackgroundAutologous or allogeneic natural killer (NK) cells possess efficient cytotoxicity against tumor cells without severe side effects such as CRS or graft-versus-host disease (GvHD). In addition to chimeric antigen receptor (CAR) strategy, antibody-cell conjugates (ACC) platform provides more efficient way to arm NK cells with binding specificity and enhanced potency against target cells. In this work, we develop a NK cell therapy product ACE1702, a novel NK cell line oNK conjugated with trastuzumab, and assess its potency against HER2+ solid tumors.Methods oNK cells were covalently conj

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Minami, Hiroaki, Keiji Nogami, Takehisa Kitazawa, Kunihiro Hattori, and Midori Shima. "FVIII Heavy Chain Enhances Tenase Activity Induced By FVIIIa Mimicking Bispesific Antibody, ACE910." Blood 124, no. 21 (2014): 1481. http://dx.doi.org/10.1182/blood.v124.21.1481.1481.

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Abstract Background: ACE910, asymmetric bispecific monoclonal antibodies to activated factor IX (IXa) and factor X, mimics the cofactor function of activated factor VIII (VIIIa) by modulating an optimal position on the tenase assembly. The estimated therapeutic range of ACE910 shows ~30% of thrombin generation in native tenase assembly, supporting that the structure on ACE910-mimicking tenase assembly is different from that on native tenase. Being close to physiological structure consisting from factor IXa, factor X, and factor VIIIa is important for potentiating the clotting function. We exam

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Yada, Koji, Keiji Nogami, Tomoko Matsumoto, Takehisa Kitazawa, Kunihiro Hattori, and Midori Shima. "Activated Protein C-Catalyzed Factor Va Inactivation Predominantly Contributes to the Downregulation of Coagulation Rather Than Factor VIIIa Inactivation." Blood 124, no. 21 (2014): 4222. http://dx.doi.org/10.1182/blood.v124.21.4222.4222.

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Abstract Activated protein C (APC) directly inactivates factor (F)Va and FVIIIa dependently of protein S (PS), and furthermore inactivates FVIIIa through cofactor function of FV. Any impairment in these inactivation pathways may increase thrombotic risk. A previous report described that the APC resistance (APCR) associated with FV-Leiden was mainly due to the impaired cofactor activity of FV (Castoldi et al. Blood 2004;103, 4173). We have recently reported that FV-Nara carrying W1920R mutation exhibited APCR caused by a loss of FVa susceptibility to APC and APC cofactor activity resulting in m

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Takeyama, Masahiro, Keiji Nogami, Tomoko Matsumoto, Takehisa Kitazawa, Kunihiro Hattori, and Midori Shima. "Anti-Factor IXa/Factor X Antibody (ACE910) Improves the Coagulation Function in Acquired Hemophilia A ex vivo." Blood 126, no. 23 (2015): 3565. http://dx.doi.org/10.1182/blood.v126.23.3565.3565.

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Abstract <Introduction> Acquired hemophilia A (AHA) is a rare bleeding disorder in which autoantibodies (autoAbs) against coagulation factor (F)VIII impair the coagulation system. Anti-FVIII autoAbs developed in AHA are polyclonal and the majority of these autoAbs bind to the A2, A3, and/or C2 domains in FVIII. Different inhibitory actions of anti-FVIII autoAbs, depending on their epitopes, are well-known. We have recently developed a humanized anti-FIXa/X bispecific antibody, ACE910, which mimics the cofactor function of FVIIIa even in the presence of anti-FVIII alloantibodies. <Aim&

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Muto, Atsushi, Takehisa Kitazawa, Kazutaka Yoshihasi, et al. "Hemostatic Effect of a Novel Bispecific Antibody (ACE910) Against Activated Factor IX and Factor X in an Acquired Hemophilia A Model." Blood 120, no. 21 (2012): 42. http://dx.doi.org/10.1182/blood.v120.21.42.42.

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Abstract Abstract 42 Background: Hemophilia A is treated by intravenous replacement therapy with factor VIII (FVIII), either on demand to resolve bleeding or as a prophylactic to prevent bleeding. Recently, routine prophylactic treatment is recommended to effectively prevent bleeding and to reduce bleeding-related chronic joint damage. However, the need for frequent intravenous injections of FVIII negatively affects patients' quality of life and their adherence to the routine prophylactic regimen. More importantly, approximately 30% of severe hemophilia A patients develop inhibitory antibodies

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Yada, Koji, Keiji Nogami, Yasuaki Shida, Masahiro Takeyama, Ryu Kasai, and Midori Shima. "Enhanced Global Hemostatic Potentials with a Bispecific Antibody to Factors IXa and X (ACE910) in the Whole Blood By Rotation Thromboelastometry (ROTEM)." Blood 126, no. 23 (2015): 3503. http://dx.doi.org/10.1182/blood.v126.23.3503.3503.

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Abstract Background: ACE910, a humanized bispecific antibody to factor (F) IXa and FX mimicking the functions of FVIII, exerts tenase activities without FVIII (a) (Kitazawa et al. Nature Medicine. 2012;18, 1570). In primate hemophilia A (HA) models, the hemostatic enhancing effect of ACE910 has been reported and the clinical study investigating the effect and safety of ACE910 for human HA patients is on-going. However, the hemostatic effect of ACE910 remains unquantified and difficult to be evaluated. Objectives: In this study, we evaluated the viscoelastmetric parameters in the whole blood ob

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Shima, Midori, Hideji Hanabusa, Masashi Taki, et al. "Safety and Prophylactic Efficacy Profiles of ACE910, a Humanized Bispecific Antibody Mimicking the FVIII Cofactor Function, in Japanese Hemophilia A Patients Both without and with FVIII Inhibitors: First-in-Patient Phase 1 Study." Blood 124, no. 21 (2014): 691. http://dx.doi.org/10.1182/blood.v124.21.691.691.

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Abstract Background: Although routine supplementation of exogenous factor VIII (FVIII) effectively prevents bleeding complications in hemophilia A patients, the development of FVIII inhibitors and the need for frequent venous access are still problematic. To overcome these medical problems, a humanized bispecific antibody to factors IXa and X (ACE910) mimicking the FVIII cofactor function has been created. Objectives: To investigate the safety, pharmacokinetic and pharmacodynamic profiles of ACE910 as well as its prophylactic efficacy on bleeding, a first-in-patient open-label phase I study wa

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Uchida, Naoki, Takehiko Sambe, Koichiro Yoneyama, et al. "A first-in-human phase 1 study of ACE910, a novel factor VIII–mimetic bispecific antibody, in healthy subjects." Blood 127, no. 13 (2016): 1633–41. http://dx.doi.org/10.1182/blood-2015-06-650226.

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Key Points Single subcutaneous dosing of ACE910 has a linear PK profile, a half-life of 4 to 5 weeks, and FVIII-mimetic procoagulant activity in humans. ACE910 at doses up to 1 mg/kg is well tolerated and has no notable adverse hypercoagulable effect in healthy Japanese and white adults.

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Shida, Yasuaki, Keiji Nogami, Hiroaki Minami, et al. "Distinct Localization of Coagulation Factor VIII, Von Willebrand Factor and Factor VIIIa-Mimetic Bispecific Antibody Contributing to Thrombus Formation Under Whole Blood Flow Conditions." Blood 124, no. 21 (2014): 1483. http://dx.doi.org/10.1182/blood.v124.21.1483.1483.

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Abstract Background Factor VIII (FVIII) is an essential factor for coagulation system in the intrinsic pathway. Due to the short survival of FVIII in the plasma circulation, it requires von Willebrand factor (VWF) as a carrier protein to maintain the optimal level for hemostasis. VWF also plays an important role in primary hemostasis by bridging platelets to exposed subendothelial collagens, especially under high shear flow environment. Since VWF carries FVIII, it is conceivable that VWF takes FVIII to the sites of vascular injury. However, the role of FVIII at the local sites under flow condi

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Zhang, L. J., J. L. Chen, B. L. Yang, X. G. Kong, D. Bourguet, and G. Wu. "Thermotolerance, oxidative stress, apoptosis, heat-shock proteins and damages to reproductive cells of insecticide-susceptible and -resistant strains of the diamondback moth Plutella xylostella." Bulletin of Entomological Research 107, no. 4 (2017): 513–26. http://dx.doi.org/10.1017/s0007485317000049.

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AbstractIn this study, we investigated thermotolerance, several physiological responses and damage to reproductive cells in chlorpyrifos-resistant (Rc) and -susceptible (Sm) strains of the diamondback moth, Plutella xylostella subjected to heat stress. The chlorpyrifos resistance of these strains was mediated by a modified acetylcholinesterase encoded by an allele, ace1R, of the ace1 gene. Adults of the Rc strain were less heat resistant than those of the Sm strain; they also had lower levels of enzymatic activity against oxidative damage, higher reactive oxygen species contents, weaker upregu

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Kanematsu, Takeshi, Nobuaki Suzuki, Naomi Sanda, et al. "Clinical Course and Management of Surgical Emergency in a Severe Hemophilia a Patient Under Weekly Subcutaneous Administration of a Bispecific Antibody to Factors IXa and X (ACE910)." Blood 126, no. 23 (2015): 1099. http://dx.doi.org/10.1182/blood.v126.23.1099.1099.

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Abstract Background FVIIIa acts as a cofactor in the intrinsic pathway in which FIXa activates FX. ACE910 is a FIXa/FX-recognizing bispecific antibody that was designed to be a replacement for FVIIIa. Because of its nature, ACE910 is not affected by FVIII inhibitor. A clinical trial is now being conducted for the potential effect in the prophylactic treatment for bleeding hemophilia A patients. Here we present the perioperative care of a patient who had incidentally suffered from appendicitis and underwent an emergency surgery during the clinical trial. Methods Plasma ACE910 concentration and

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Garcia, Martin. "Diversity Events at ACE12." Journal - American Water Works Association 104, no. 5 (2012): 106–7. http://dx.doi.org/10.5942/jawwa.2012.104.0081.

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Maroney, Thomas T., Yusen He, Srujankumar Dhannapuneni, Nikita C. Shah, Amy Iarrobino Laughlin, and Tomas Dvorak. "Independent validation of 30-day emergency department visit after initial chemotherapy A-PROACCT model." Journal of Clinical Oncology 42, no. 16_suppl (2024): e23243-e23243. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e23243.

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e23243 Background: This study assessed model performance and, more importantly, the clinical usefulness of the PROACCT model created by Grant et al. (JAMA, 2019), refined as A-PROACCT by Stein et al. (JOP, 2023) with data from Orlando Health. The predictive performance of models anticipating acute care events within thirty days (ACE30) of initial chemotherapy administration (ICA) were evaluated. Methods: Stein et al. models classified high-risk patients as those whose model output risk score was at or above the 90th percentile. They studied 5153 ICAs between July and November of 2021, of which

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Yada, Koji, Keiji Nogami, Takehisa Kitazawa, Kunihiro Hattori, and Midori Shima. "ACE910 Facilitates Its Hemostatic Effect with the Lower Concentration of Factor X Than That Required for Factor VIIa-Driven Coagulation." Blood 126, no. 23 (2015): 1077. http://dx.doi.org/10.1182/blood.v126.23.1077.1077.

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Abstract The hemostatic effect of bypassing agents such as recombinant (r) factor (F)VIIa and activated prothrombin complex concentrates (aPCC) for hemophilia A with inhibitors (HA-inh) is not always stable (Berntope, Haemophilia 2009). The mechanism(s) of its instability remain unclear, however. We have recently reported the HA-inh case showing the attenuated responsiveness to aPCC (Ogiwara, Int J Hematol. 2014). Some groups reported the hemostatic effects of the complex concentrates of FVIIa and FX (Shirahata, Haemophilia 2012) in HA-inh, suggesting that FX would play the key role in the hem

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Igawa, Tomoyuki, Zenjiro Sampei, Tetsuhiro Soeda, et al. "Generation of a Novel Bispecific Antibody (ACE910) Against Activated Factor IX and Factor X Mimicking the Function of Factor VIII Cofactor Activity." Blood 120, no. 21 (2012): 1126. http://dx.doi.org/10.1182/blood.v120.21.1126.1126.

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Abstract Abstract 1126 Exogenous factor VIII (FVIII) is used to reduce bleeding complications in patients with severe hemophilia A. However, there are two drawbacks of current routine prophylaxis by FVIII. One is the requirement of frequent intravenous administration due to its short half-life and low subcutaneous bioavailability of FVIII. Second is the development of anti-FVIII antibodies (inhibitors) in approximately 30% of the severe patients which deprives the patients from routine prophylaxis by FVIII. To overcome these drawbacks, bispecific IgG antibody against activated factor IX (FIXa)

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Peña, Maria Marjorette O., Keith A. Koch, and Dennis J. Thiele. "Dynamic Regulation of Copper Uptake and Detoxification Genes in Saccharomyces cerevisiae." Molecular and Cellular Biology 18, no. 5 (1998): 2514–23. http://dx.doi.org/10.1128/mcb.18.5.2514.

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ABSTRACT The essential yet toxic nature of copper demands tight regulation of the copper homeostatic machinery to ensure that sufficient copper is present in the cell to drive essential biochemical processes yet prevent the accumulation to toxic levels. In Saccharomyces cerevisiae, the nutritional copper sensor Mac1p regulates the copper-dependent expression of the high affinity Cu(I) uptake genesCTR1, CTR3, and FRE1, while the toxic copper sensor Ace1p regulates the transcriptional activation of the detoxification genes CUP1, CRS5, andSOD1 in response to copper. In this study, we characterize

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