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Zeitschriftenartikel zum Thema „ACPD“

Autor: Grafiati

Veröffentlicht am 4. Juni 2021

Zuletzt aktualisiert am 27. Juli 2025

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1

Lovinger, D. M., E. Tyler, S. Fidler, and A. Merritt. "Properties of a presynaptic metabotropic glutamate receptor in rat neostriatal slices." Journal of Neurophysiology 69, no. 4 (1993): 1236–44. http://dx.doi.org/10.1152/jn.1993.69.4.1236.

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1. The effect of the metabotropic glutamate receptor agonist trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) on glutamatergic transmission at corticostriate synapses was examined using slices of neostriatum. Field potential recordings were performed in slices from adult animals, and the effects of t-ACPD on the synaptically driven population spike were examined. Tight-seal whole-cell recordings were made in slices from 2 to 4-wk-old rats, and effects of t-ACPD on the amplitude of excitatory postsynaptic potentials (EPSPs) and postsynaptic neuronal membrane properties were examined. In

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Glaum, S. R., N. T. Slater, D. J. Rossi, and R. J. Miller. "Role of metabotropic glutamate (ACPD) receptors at the parallel fiber-Purkinje cell synapse." Journal of Neurophysiology 68, no. 4 (1992): 1453–62. http://dx.doi.org/10.1152/jn.1992.68.4.1453.

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1. The role of metabotropic glutamate receptors at the parallel fiber (PF)-Purkinje cell synapse in cerebellum was studied by examining the actions of the active stereoisomer (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid [1S,3R-ACPD (25-50 microM)] on fura-2-loaded, patch-clamped rat Purkinje cells in thin slices. 2. The bath application of 1S,3R-ACPD evoked a direct post-synaptic depolarization that readily desensitized during prolonged (> 1 min) applications of the drug. This depolarizing response to 1S,3R-ACPD differed from the slow depolarization to 1S,3R-ACPD observed in cortical n

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Sciancalepore, M., F. Stratta, N. D. Fisher, and E. Cherubini. "Activation of metabotropic glutamate receptors increase the frequency of spontaneous GABAergic currents through protein kinase A in neonatal rat hippocampal neurons." Journal of Neurophysiology 74, no. 3 (1995): 1118–22. http://dx.doi.org/10.1152/jn.1995.74.3.1118.

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1. The tight-seal whole cell recording technique was used to study the effects of the metabotropic glutamate receptor (mGluR) agonist, trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) on spontaneous gamma-aminobutyric acid (GABA)-mediated synaptic currents in neonatal rat CA1 hippocampal neurons in slices obtained from postnatal (P) days P6-P12. 2. Bath application of t-ACPD (3-30 microM), in the presence of kynurenic acid, induced a concentration-dependent increase in frequency but not in amplitude of spontaneous GABAergic currents. The mean frequency ratio (t-ACPD 10 microM over cont

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Cohen, A. S., and W. C. Abraham. "Facilitation of long-term potentiation by prior activation of metabotropic glutamate receptors." Journal of Neurophysiology 76, no. 2 (1996): 953–62. http://dx.doi.org/10.1152/jn.1996.76.2.953.

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1. The influence of prior metabotropic glutamate receptor (mGluR) activation on subsequent long-term potentiation (LTP) induction was investigated with the use of the mGluR agonist 1-amino-cyclopentane-1S,3R-dicarboxylic acid (ACPD, 20 microM). Field potential recordings were made in the stratum radiatum of CA1 slices taken from young adult male rats and from which CA3 was routinely dissected. Theta burst stimulation (TBS) just above threshold was used to induce LTP. 2. A 10-min bath application of ACPD begun 30 min before the TBS facilitated the induction of LTP in a dose-dependent manner and

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Desai, M. A., and P. J. Conn. "Excitatory effects of ACPD receptor activation in the hippocampus are mediated by direct effects on pyramidal cells and blockade of synaptic inhibition." Journal of Neurophysiology 66, no. 1 (1991): 40–52. http://dx.doi.org/10.1152/jn.1991.66.1.40.

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1. Phosphoinositide hydrolysis-linked excitatory amino acid (EAA) receptors (ACPD receptors) are selectively activated by the glutamate analogue trans-1-amino-1,3-cyclopentanedicarboxylic acid (trans-ACPD). Regional analysis of trans-ACPD-induced phosphoinositide hydrolysis indicates that this response is greater in the hippocampus than in other brain regions. Therefore we designed a series of studies aimed at testing the hypothesis that activation of this receptor modulates synaptic function in the hippocampal region. 2. We report that trans-ACPD dramatically altered field population spikes a

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Kelly, Aine, and Marina A. Lynch. "LTP occludes the interaction between arachidonic acid and ACPD and NGF and ACPD." NeuroReport 9, no. 18 (1998): 4087–91. http://dx.doi.org/10.1097/00001756-199812210-00015.

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Thoreson, W. B., and R. F. Miller. "Actions of (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) in retinal ON bipolar cells indicate that it is an agonist at L-AP4 receptors." Journal of General Physiology 103, no. 6 (1994): 1019–34. http://dx.doi.org/10.1085/jgp.103.6.1019.

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Metabotropic glutamate receptors (mGluRs) include receptors sensitive to L-2-amino-4-phosphonobutyrate (L-AP4) and 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD). To determine whether 1S,3R-ACPD is an agonist at retinal L-AP4 receptors, whole cell voltage clamp recordings were obtained from mudpuppy ON bipolar cells in a superfused retinal slice and L-AP4 and 1S,3R-ACPD were bath applied. Both compounds evoked similar outward currents which reversed near 0 mV and were accompanied by an increased input resistance. Responses to both agonists washed out in parallel suggesting they a

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Curry, Kenneth. "Rigid analogues as probes of excitatory amino acid receptors." Canadian Journal of Physiology and Pharmacology 69, no. 7 (1991): 1076–83. http://dx.doi.org/10.1139/y91-159.

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The classes of coumpounds to be discussed are based on rigid analogues of glutamic and aspartic acids. The glutamate analogue 1-amino-1,3-cyclopentane dicarboxylic acid (1,3-ACPD) exists as two enantiomeric pairs of geometric isomers. The absolute configurations were assigned and the compounds were found to differentiate between the kainic acid (KA) and N-methyl-D-aspartic acid (NMDA) receptor subtypes when applied iontophoretically to hippocampal CA1 pyramidal neurones. The results indicate a high degree of specificity for the interaction of D-cis- 1,3-ACPD with the NMDA receptor, while the r

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Tennigkeit, Frank, Dietrich W. F. Schwarz, and Ernest Puil. "Effects of Metabotropic Glutamate Receptor Activation in Auditory Thalamus." Journal of Neurophysiology 82, no. 2 (1999): 718–29. http://dx.doi.org/10.1152/jn.1999.82.2.718.

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Metabotropic glutamate receptors (mGluRs) are expressed predominantly in dendritic regions of neurons of auditory thalamus. We studied the effects of mGluR activation in neurons of the ventral partition of medial geniculate body (MGBv) using whole cell current- and voltage-clamp recordings in brain slices. Bath application of the mGluR-agonist, 1S,3R-1-aminocyclopentan-1,3-dicarboxylic acid or 1S,3R-ACPD (5–100 μM), depolarized MGBv neurons ( n = 67), changing evoked response patterns from bursts to tonic firing as well as frequency responses from resonance (∼1 Hz) to low-pass filter character

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Breakwell, N. A., M. J. Rowan, and R. Anwyl. "Metabotropic glutamate receptor dependent EPSP and EPSP-spike potentiation in area CA1 of the submerged rat hippocampal slice." Journal of Neurophysiology 76, no. 5 (1996): 3126–35. http://dx.doi.org/10.1152/jn.1996.76.5.3126.

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1. We reexamined the important areas of conflict in (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid [(1S,3R)-ACPD]-induced potentiation of the field excitatory postsynaptic potential (EPSP) and, for the first time, investigated the role of mGluRs in EPSP-spike (E-S) coupling. 2. (1S,3R)-ACPD (10 microM) bath applied for 20 min consistently induced a long-lasting potentiation of the dendritic EPSP in area CA1 of submerged rat hippocampal slices, which was considerably faster in onset than described previously. 3. This effect was not associated with any change in presynaptic fiber volley but w

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Reid, Silvia N. M., and Nigel W. Daw. "Activation of metabotropic glutamate receptors has different effects in different layers of cat visual cortex." Visual Neuroscience 14, no. 1 (1997): 83–88. http://dx.doi.org/10.1017/s0952523800008786.

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AbstractSingle neurons were recorded in cat primary visual cortex, and the effect of iontophoresis of the metabotropic glutamate agonist 1S,3R-aminocyclopentane-1.3-dicarboxylic acid (ACPD) was observed. In nearly all cases (41/43), ACPD reduced the visual response. In some cases ACPD also reduced spontaneous activity (24/43), and in other cases ACPD increased spontaneous activity (18/43). Increases were generally seen in infragranular layers (V and VI), and decreases in supragranular layers (II and III). The reduction in the visual response was also largest in supragranular layers. We conclud

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Kinney, G. A., and N. T. Slater. "Potentiation of mossy fiber-evoked EPSPs in turtle cerebellar Purkinje cells by the metabotropic glutamate receptor agonist 1S,3R-ACPD." Journal of Neurophysiology 67, no. 4 (1992): 1006–8. http://dx.doi.org/10.1152/jn.1992.67.4.1006.

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1. The effects of the metabotropic glutamate receptor (mGluR) agonist 1S,3R-ACPD on excitatory postsynaptic potentials (EPSPs) evoked by stimulation of mossy fibers (MF) and parallel fibers (PF) were examined in turtle cerebellar Purkinje cells. 2. 1S,3R-ACPD (1-25 microM) reversibly potentiated the amplitude of the MF-evoked EPSPs and revealed a late, slow EPSP component, but was without effect on PF-evoked EPSPs. The potentiation of both components of MF-evoked EPSPs was dose dependent, with an ED50 of approximately 3 microM. At higher doses (15-25 microM) 1S,3R-ACPD produced a direct depola

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Tian, N., and M. M. Slaughter. "Pharmacological similarity between the retinal APB receptor and the family of metabotropic glutamate receptors." Journal of Neurophysiology 71, no. 6 (1994): 2258–68. http://dx.doi.org/10.1152/jn.1994.71.6.2258.

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1. We performed current-clamp and voltage-clamp experiments in the amphibian retina to examine the effects of 1-amino-1,3-cyclopentanedicarboxylic acid (1S,3R ACPD), which is a selective agonist for the family of metabotropic glutamate receptors. 2. 1S,3R ACPD was found to selectively block the light responses of ON bipolar cells. It did not suppress the responses of horizontal cells of OFF bipolar cells. It blocked ON but not OFF responses of third-order retinal neurons. 3. 1S,3R ACPD mimicked the effect of the photoreceptor transmitter at the ON bipolar synapse. It reduced an inward current

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Cohen, Akiva S., Christine M. Coussens, Clarke R. Raymond, and Wickliffe C. Abraham. "Long-Lasting Increase in Cellular Excitability Associated With the Priming of LTP Induction in Rat Hippocampus." Journal of Neurophysiology 82, no. 6 (1999): 3139–48. http://dx.doi.org/10.1152/jn.1999.82.6.3139.

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The mechanisms underlying the facilitation (priming) of long-term potentiation (LTP) by prior activation of metabotropic glutamate receptors (mGluRs) were investigated in area CA1 of rat hippocampal slices. In particular, we focused on whether a long-lasting increase in postsynaptic excitability could account for the facilitated LTP. Administration of the mGluR agonist 1S,3R-aminocyclopentanedicarboxylic acid (ACPD) produced rapid decreases in the amplitude of both the slow spike afterhyperpolarization (AHPslow) and spike frequency adaptation recorded intracellularly from CA1 pyramidal cells.

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Martín, M., J. M. Sanz, M. Ros, and A. Cubero. "Metabotropic glutamate receptor analogues inhibit p[NH]ppG-stimulated phospholipase C activity in bovine brain coated vesicles: involvement of a pertussis toxin-sensitive G-protein." Biochemical Journal 307, no. 3 (1995): 851–57. http://dx.doi.org/10.1042/bj3070851.

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Guanosine 5′-[beta gamma-imido]triphosphate (p[NH]ppG)-stimulated phospholipase C (PLC) activity in bovine brain coated vesicles is inhibited by glutamate agonists. In the present study we show that quisqualic acid (QA), (+/-)-trans-1-aminocyclopentane-1,3-dicarboxylate (trans-ACPD), glutamic acid and ibotenic acid inhibited p[NH]ppG-stimulated PLC by 44, 41, 36 and 25% respectively. Carbachol also produced an inhibition of p[NH]ppG-stimulated PLC by 45%. The inhibition caused by trans-ACPD and QA was dose-dependent. DL-2-Amino-3-phosphonopropionic acid and (RS)-alpha-methyl-4-carboxyphenylgly

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Martin, Gilles, Zhiguo Nie, and George R. Siggins. "Metabotropic Glutamate Receptors Regulate N-Methyl-d-Aspartate–Mediated Synaptic Transmission in Nucleus Accumbens." Journal of Neurophysiology 78, no. 6 (1997): 3028–38. http://dx.doi.org/10.1152/jn.1997.78.6.3028.

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Martin, Gilles, Zhiguo Nie, and George R. Siggins. Metabotropic glutamate receptors regulate N-methyl-d-aspartate–mediated synaptic transmission in nucleus accumbens. J. Neurophysiol. 78: 3028–3038, 1997. We recorded intracellularly from core nucleus accumbens (NAcc) neurons in brain slices to study the regulation by metabotropic glutamate receptors (mGluRs) of pharmacologically isolated N-methyl-d-aspartate–mediated excitatory postsynaptic currents (NMDA-EPSCs). Monosynaptic NMDA-EPSCs, evoked by local stimulation, were isolated by superfusion of the non-NMDA and γ-aminobutyric acid-A (GABAA)

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Lang, C. H., and M. Ajmal. "Metabolic, hormonal, and hemodynamic changes induced by metabotropic excitatory amino acid agonist (1S,3R)-ACPD." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 268, no. 4 (1995): R1026—R1033. http://dx.doi.org/10.1152/ajpregu.1995.268.4.r1026.

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The purpose of the present study was to determine whether central administration of (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (ACPD), a selective metabotropic glutamate receptor agonist, would stimulate glucose metabolism, activate the hypothalamic-pituitary-adrenal axis, or influence pancreatic endocrine secretion. Intracerebroventricular injection of ACPD increased arterial glucose levels by 60% within 15 min, which were sustained throughout the 3-h experimental protocol. This hyperglycemia resulted from an early increase in hepatic glucose production (HGP, 88%) that exceeded the inc

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Bhardwaj, Anish, Frances J. Northington, Lee J. Martin, Daniel F. Hanley, Richard J. Traystman, and Raymond C. Koehler. "Characterization of Metabotropic Glutamate Receptor-Mediated Nitric Oxide Production in Vivo." Journal of Cerebral Blood Flow & Metabolism 17, no. 2 (1997): 153–60. http://dx.doi.org/10.1097/00004647-199702000-00004.

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We tested the hypothesis that stimulation of metabotropic glutamate receptors (mGluRs) increases nitric oxide (NO) production in the hippocampus in vivo. Microdialysis probes were placed bilaterally into the CA3 region of the hippocampus of adult Sprague–Dawley rats under pentobarbital anesthesia. Probes were perfused for 5 h with artificial cerebrospinal fluid (CSF) containing 3 μM [14C]-L-arginine. Recovery of [14C]-L-citrulline in the effluent was used as a marker of NO production. In nine groups of rats, increases in [14C]-L-citrulline recovery were compared between right- and left-sided p

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Abdul-Ghani, M. A., T. A. Valiante, P. L. Carlen, and P. S. Pennefather. "Metabotropic glutamate receptors coupled to IP3 production mediate inhibition of IAHP in rat dentate granule neurons." Journal of Neurophysiology 76, no. 4 (1996): 2691–700. http://dx.doi.org/10.1152/jn.1996.76.4.2691.

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1. Whole cell recordings from dentate granule neurons in the hippocampal slice preparation reveal that (1 S, 3R)-1-aminocyclopentane-1,3-dicarboxylic acid (ACPD), a selective agonist at metabotropic glutamate receptors (mGluRs), inhibits a calcium-activated potassium current (IAHP) responsible for the postspike after-hyperpolarization. Inclusion of 1 mM of the Ca2+ chelator ethylene glycol-bis (beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid in the patch pipette reduced the inhibitory action of ACPD on IAHP while having no effect on a similar action of serotonin (5-HT). Thus the known action

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Linden, D. J., M. Smeyne, and J. A. Connor. "Trans-ACPD, a metabotropic receptor agonist, produces calcium mobilization and an inward current in cultured cerebellar Purkinje neurons." Journal of Neurophysiology 71, no. 5 (1994): 1992–98. http://dx.doi.org/10.1152/jn.1994.71.5.1992.

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1. 1-aminocyclopentane-trans-1,3-dicarboxylic acid (t-ACPD), a racemic mixture of 1-aminocyclopentane-1S,3R-dicarboxylic acid and 1-aminocyclopentane-1R,3S-dicarboxylic acid, a selective agonist of the metabotropic glutamate receptor, was applied to mouse Purkinje neurons (PNs) in culture. Measurements of free intracellular Ca2+ were made using fura-2 microfluorimetric imaging and of membrane current using perforated-patch voltage-clamp recording in separate experiments. 2. Brief pulses of t-ACPD (< or = 100 microM, 1–5 s) consistently produced a large (200–600 nM) increase in dendritic Ca2

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Foley, C. Michael, Helen W. Vogl, Patrick J. Mueller, Meredith Hay, and Eileen M. Hasser. "Cardiovascular response to group I metabotropic glutamate receptor activation in NTS." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 276, no. 5 (1999): R1469—R1478. http://dx.doi.org/10.1152/ajpregu.1999.276.5.r1469.

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Glutamate is the proposed neurotransmitter of baroreceptor afferents at the level of the nucleus tractus solitarius (NTS). Exogenous glutamate in the NTS activates neurons through ionotropic and metabotropic glutamate receptors (mGluRs). This study tested the hypothesis that group I mGluRs in the NTS produce depressor, bradycardic, and sympathoinhibitory responses. In urethan-anesthetized rats, unilateral 30-nl microinjections of the group I-selective mGluR agonist 3,5-dihydroxyphenylglycine (DHPG) into the NTS decreased mean arterial pressure, heart rate, and lumbar sympathetic nerve activity

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Amos, Brian J., and Mitchell Chesler. "Characterization of an Intracellular Alkaline Shift in Rat Astrocytes Triggered by Metabotropic Glutamate Receptors." Journal of Neurophysiology 79, no. 2 (1998): 695–703. http://dx.doi.org/10.1152/jn.1998.79.2.695.

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Amos, Brian J. and Mitchell Chesler. Characterization of an intracellular alkaline shift in rat astrocytes triggered by metabotropic glutamate receptors. J. Neurophysiol. 79: 695–703, 1998. The modulation of intracellular pH by activation of metabotropic glutamate receptors was investigated in cultured and acutely dissociated rat astrocytes. One minute superfusion of 100 μM (1S,3R)-1-aminocyclopentane-1,3-dicarboxcylic acid (ACPD) evoked an alkaline shift of 0.13 ± 0.013 (mean ± SE) and 0.16 ± 0.03 pH units in cultured (cortical or cerebellar) and acutely dissociated cortical astrocytes, respe

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Liu, Y. B., J. F. Disterhoft, and N. T. Slater. "Activation of metabotropic glutamate receptors induces long-term depression of GABAergic inhibition in hippocampus." Journal of Neurophysiology 69, no. 3 (1993): 1000–1004. http://dx.doi.org/10.1152/jn.1993.69.3.1000.

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1. The long-term enhancement of synaptic excitability in CA1 hippocampal pyramidal neurons produced by activation of metabotropic glutamate receptors (mGluRs) was studied in rabbit hippocampal slices in vitro. 2. Bath application of the mGluR agonist (1S,3R)-1-aminocyclopentane-1,3- dicarboxylic acid (1S,3R-ACPD) (5-20 microM) for 20 min produced a reversible depolarization of membrane potentiatil, blockade of spike accommodation, and increase in input resistance of CA1 neurons. However, a long-lasting increase in synaptic excitability was observed: single stimuli applied to the Schaffer colla

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Yang, Xiong-Li, and Samuel M. Wu. "Coexistence and function of glutamate receptor subtypes in the horizontal cells of the tiger salamander retina." Visual Neuroscience 7, no. 4 (1991): 377–82. http://dx.doi.org/10.1017/s0952523800004867.

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AbstractEffects of the major glutamate receptor agonists, kainate (KA), α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), quisqualate (QA), N-methyl-D-aspartate (NMDA), L-α-amino-4-phosphonobutyrate (L-AP4), and trans-l-aminocyclopentane-1,3-dicarboxylic acid (ACPD) on horizontal cells (HCs) were studied in superfused larval tiger salamander retina. 20 μM of KA, AMPA, and QA mimicked the action of 3 mM glutamate in the absence and presence of 1 mM Co2+-20 μM 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) blocked the actions of KA and AMPA, but not those of QA and glutamate, indicative

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Holmes, K. H., N. B. Keele, V. L. Arvanov, and P. Shinnick-Gallagher. "Metabotropic glutamate receptor agonist-induced hyperpolarizations in rat basolateral amygdala neurons: receptor characterization and ion channels." Journal of Neurophysiology 76, no. 5 (1996): 3059–69. http://dx.doi.org/10.1152/jn.1996.76.5.3059.

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1. Metabotropic glutamate receptor (mGluR)-agonist-induced hyperpolarizations and corresponding outward currents were analyzed in basolateral amygdala (BLA) neurons in rat brain slice preparations with current-clamp and single-electrode voltage-clamp recording to characterize the mGluR subtype(s) and the ion channel(s) mediating this response. 2. The mGluR agonist (1S,3R)-1-amino-cyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) induced a membrane hyperpolarization or outward current in BLA neurons in a concentration-dependent manner (median effective concentration = 34 microM; range = 10-200 mi

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Kinney, G. A., and N. T. Slater. "Potentiation of NMDA receptor-mediated transmission in turtle cerebellar granule cells by activation of metabotropic glutamate receptors." Journal of Neurophysiology 69, no. 2 (1993): 585–94. http://dx.doi.org/10.1152/jn.1993.69.2.585.

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1. The effects of metabotropic glutamate receptor (mGluR) agonists on excitatory postsynaptic potentials (EPSPs) evoked by stimulation of mossy fibers (MF) and parallel fibers (PF) were examined in turtle cerebellar Purkinje cells. 2. The mGluR agonist 1S,3R-ACPD (1-25 microM) reversibly potentiated the amplitude of the MF-evoked EPSPs, but was without effect on PF-evoked EPSPs. The potentiation of MF-evoked EPSPs was dose-dependent, with a median effective dose (ED50) of approximately 4.4 microM. At higher doses (15-25 microM) 1S,3R-ACPD produced a direct depolarization of Purkinje cells in 5

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Burke, J. P., and J. J. Hablitz. "Modulation of epileptiform activity by metabotropic glutamate receptors in immature rat neocortex." Journal of Neurophysiology 73, no. 1 (1995): 205–17. http://dx.doi.org/10.1152/jn.1995.73.1.205.

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1. Intracellular and extracellular recordings were obtained from neocortical brain slices of immature rats (postnatal days 9-16) maintained in vitro. Spontaneous and evoked epileptiform discharges (termed paroxysmal depolarizing shifts or PDSs) were recorded from upper cortical laminae (layers II-III) after exposure to the gamma-aminobuturic acid-A receptor antagonist, bicuculline methiodide. The effects of mGluR activation on PDS duration, spontaneous frequency, and threshold for evoking a PDS were determined. Putative mGluR agonists and antagonists also were tested. 2. Bath application of th

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Sergent, Petra, Juan Carlos Pinto-Cárdenas, Adhara Jaciel Arreguin Carrillo, et al. "An Abscopal Effect on Lung Metastases in Canine Mammary Cancer Patients Induced by Neoadjuvant Intratumoral Immunotherapy with Cowpea Mosaic Virus Nanoparticles and Anti-Canine PD-1." Cells 13, no. 17 (2024): 1478. http://dx.doi.org/10.3390/cells13171478.

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Neoadjuvant intratumoral (IT) therapy could amplify the weak responses to checkpoint blockade therapy observed in breast cancer (BC). In this study, we administered neoadjuvant IT anti-canine PD-1 therapy (IT acPD-1) alone or combined with IT cowpea mosaic virus therapy (IT CPMV/acPD-1) to companion dogs diagnosed with canine mammary cancer (CMC), a spontaneous tumor resembling human BC. CMC patients treated weekly with acPD-1 (n = 3) or CPMV/acPD-1 (n = 3) for four weeks or with CPMV/acPD-1 (n = 3 patients not candidates for surgery) for up to 11 weeks did not experience immune-related advers

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Krieger, P., A. el Manira, and S. Grillner. "Activation of pharmacologically distinct metabotropic glutamate receptors depresses reticulospinal-evoked monosynaptic EPSPs in the lamprey spinal cord." Journal of Neurophysiology 76, no. 6 (1996): 3834–41. http://dx.doi.org/10.1152/jn.1996.76.6.3834.

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1. Different metabotropic glutamate receptors (mGluRs) can modulate synaptic transmission in different regions in the CNS, but their roles at individual synaptic connections have not been detailed. We used paired intracellular recordings from reticulospinal axons and their postsynaptic target neurons in the lamprey spinal cord to investigate the effects of mGluR activation on glutamatergic synaptic transmission. 2. The mGluR agonists (1S,3R)-1-aminocyclopentane-1,3-dicarboxyylic acid [(1S,3R)-ACPD] and L(+)-2-amino-4-phosphonobutyric acid (L-AP4) both reduced the amplitude of monosynaptic exci

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Molitor, Scott C., and Paul B. Manis. "Evidence for Functional Metabotropic Glutamate Receptors in the Dorsal Cochlear Nucleus." Journal of Neurophysiology 77, no. 4 (1997): 1889–905. http://dx.doi.org/10.1152/jn.1997.77.4.1889.

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Molitor, Scott C. and Paul B. Manis. Evidence for functional metabotropic glutamate receptors in the dorsal cochlear nucleus. J. Neurophysiol. 77: 1889–1905, 1997. The parallel fibers (PFs) of the dorsal cochlear nucleus (DCN) molecular layer use glutamate as a neurotransmitter. Although metabotropic glutamate receptors (mGluRs) have been identified on cells postsynaptic to the PFs, little is known about the effects of mGluR activation in PF synaptic transmission in the DCN. To investigate these effects, PF-evoked field potentials were recorded from the DCN in guinea pig brain stem slice prepa

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Packard, Mark G., Stefano F. Vecchioli, Jason P. Schroeder, and Antonella Gasbarri. "Task-Dependent Role for Dorsal Striatum Metabotropic Glutamate Receptors in Memory." Learning & Memory 8, no. 2 (2001): 96–103. http://dx.doi.org/10.1101/lm.37401.

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The effect of post-training intradorsal striatal infusion of metabotropic glutamate receptor (mGluR) drugs on memory consolidation processes in an inhibitory avoidance (IA) task and visible/hidden platform water maze tasks was examined. In the IA task, adult male Long-Evans rats received post-training intracaudate infusions of the broad spectrum mGluR antagonist α-methyl-4-carboxyphenylglycine (MCPG; 1.0, 2.0 mM/0.5 μL), the group I/II mGluR agonist 1-aminocyclopentane-1,3-carboxylic acid (ACPD; 0.5 or 1.0 μM/0.5 μL), or saline immediately following footshock training, and retention was tested

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Hylviu, B., G. Cekodhima, M. Rista, B. Shehu, M. Vandewiele, and Y. Huang. "Saving Women's Lives From Cervical Cancer: Promoting a Cost-Effective Cervical Cancer Screening Tool in Rural Albania." Journal of Global Oncology 4, Supplement 2 (2018): 158s. http://dx.doi.org/10.1200/jgo.18.54400.

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Background and context: The WHO has presented that more than 90% of deaths from cervical cancer happened in low and middle-income countries. Albania is one of them. Albania has a national cervical cancer screening program. However, the program is not well-promoted and the service is not always available at the primary public health care level. The situation worsens when it comes to rural areas. In 2016, to bridge the gap and achieve health equity the Albanian Center for Population and Development (ACPD) initiated a series of activities to promote the utilization of visual inspection with aceti

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Li, A., and E. E. Nattie. "Prolonged stimulation of respiration by brain stem metabotropic glutamate receptors." Journal of Applied Physiology 79, no. 5 (1995): 1650–56. http://dx.doi.org/10.1152/jappl.1995.79.5.1650.

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Stimulation of metabotropic glutamate receptors (mGluRs) in the retrotrapezoid nucleus (RTN) of chloralose-urethan-anesthetized rats by the mGluR agonist (1S,3R)-aminocyclopentanedicarboxylic acid [(1S,3R)-ACPD; 10 nl, 1 mM] increases integrated phrenic nerve amplitude (PNA) for > 60 min. Here we ask if the mGluR antagonist (+-)-alpha-methyl-4-carboxyphenylglycine [(+-)-MCPG] can block this effect. Using multibarreled micropipettes, we first identified RTN sites that affect respiration by noting short-lived stimulation of PNA produced by brief-duration injection of glutamate (10 nl, 100 mM)

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Pawloski-Dahm, C., and F. J. Gordon. "Evidence for a kynurenate-insensitive glutamate receptor in nucleus tractus solitarii." American Journal of Physiology-Heart and Circulatory Physiology 262, no. 5 (1992): H1611—H1615. http://dx.doi.org/10.1152/ajpheart.1992.262.5.h1611.

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Previous studies have shown that pharmacological blockade of ionotropic excitatory amino acid (EAA) receptors in the nucleus tractus solitarii (NTS) with kynurenate (Kyn) abolishes baroreceptor reflexes but fails to affect cardiovascular responses evoked by microinjections of L-glutamate (Glu) into the NTS. These observations have raised doubts as to whether Glu is a neurotransmitter of baroreceptor information in the NTS because the pharmacological actions of exogenously administered Glu are not identical to those of the neurotransmitter released in the NTS coincident with baroreceptor activa

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Godwin, D. W., J. W. Vaughan, and S. M. Sherman. "Metabotropic glutamate receptors switch visual response mode of lateral geniculate nucleus cells from burst to tonic." Journal of Neurophysiology 76, no. 3 (1996): 1800–1816. http://dx.doi.org/10.1152/jn.1996.76.3.1800.

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1. Metabotropic glutamate receptors (mGluRs) on relay cells of the lateral geniculate nucleus appear to be activated exclusively by cortical inputs. We thus sought to manipulate these receptors in an effort to gain insight into the possible role of the corticogeniculate pathway. We used in vivo recording and pharmacological techniques in cats to activate or inactivate these receptors on geniculate neurons while analyzing their response properties. 2. Iontophoretic application of the mGluR agonist 1-amino-cyclopentane-1,3-dicarboxylic acid (ACPD) to X and Y cells in the geniculate A laminae dim

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Schoepp, Darryle D., Bryan G. Johnson, Rebecca A. True, and James A. Monn. "Comparison of (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD)- and 1R,3S-ACPD-stimulated brain phosphoinositide hydrolysis." European Journal of Pharmacology: Molecular Pharmacology 207, no. 4 (1991): 351–53. http://dx.doi.org/10.1016/0922-4106(91)90010-f.

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Zhou, Fu-Ming, and John J. Hablitz. "Metabotropic Glutamate Receptor Enhancement of Spontaneous IPSCs in Neocortical Interneurons." Journal of Neurophysiology 78, no. 5 (1997): 2287–95. http://dx.doi.org/10.1152/jn.1997.78.5.2287.

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Zhou, Fu-Ming and John J. Hablitz. Metabotropic glutamate receptor enhancement of spontaneous IPSCs in neocortical interneurons. J. Neurophysiol. 78: 2287–2295, 1997. Using neocortical layer I neurons as a model for GABAergic interneurons, we have studied γ-aminobutyric acid-A (GABAA) receptor-mediated spontaneous inhibitory postsynaptic currents (IPSCs) and modulation by metabotropic glutamate receptors (mGluRs). In the presence of 0.5 μM tetrodotoxin (TTX) and ionotropic glutamate receptor antagonists and under symmetrical Cl− conditions, the mean amplitude of miniature IPSCs (mIPSCs) was ∼5

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Lu, Yong, and Edwin W. Rubel. "Activation of Metabotropic Glutamate Receptors Inhibits High-Voltage-Gated Calcium Channel Currents of Chicken Nucleus Magnocellularis Neurons." Journal of Neurophysiology 93, no. 3 (2005): 1418–28. http://dx.doi.org/10.1152/jn.00659.2004.

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Using whole cell patch-clamp recordings, we pharmacologically characterized the voltage-gated Ca2+ channel (VGCC) currents of chicken nucleus magnocellularis (NM) neurons using barium as the charge carrier. NM neurons possessed both low- and high-voltage-activated Ca2+ channel currents (HVA IBa2+). The N-type channel blocker (ω-conotoxin-GVIA) inhibited more than half of the total HVA IBa2+, whereas blockers of L- and P/Q-type channels each inhibited a small fraction of the current. Metabotropic glutamate receptor (mGluR)-mediated modulation of the HVA IBa2+ was examined by bath application of

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Schrader, L. A., and J. G. Tasker. "Presynaptic Modulation by Metabotropic Glutamate Receptors of Excitatory and Inhibitory Synaptic Inputs to Hypothalamic Magnocellular Neurons." Journal of Neurophysiology 77, no. 2 (1997): 527. http://dx.doi.org/10.1152/jn.1997.77.2.527.

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Schrader, L. A. and J. G. Tasker. Presynaptic modulation by metabotropic glutamate receptors of excitatory and inhibitory synaptic inputs to hypothalamic magnocellular neurons. J. Neurophysiol. 77: 527–536, 1997. The effects of activation of metabotropic glutamate receptors (mGluRs) on synaptic inputs to magnocellular neurons of the hypothalamic supraoptic nucleus (SON) were studied with the use of whole cell patch-clamp and microelectrode recordings in acute hypothalamic slices. Application of the mGluR agonist trans-(±)-1-amino-1,3-cyclopentane dicarboxylic acid ( trans-ACPD, 100 μM) elicite

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Schrader, L. A., and J. G. Tasker. "Modulation of Multiple Potassium Currents by Metabotropic Glutamate Receptors in Neurons of the Hypothalamic Supraoptic Nucleus." Journal of Neurophysiology 78, no. 6 (1997): 3428–37. http://dx.doi.org/10.1152/jn.1997.78.6.3428.

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Schrader, L. A. and J. G. Tasker. Modulation of multiple potassium currents by metabotropic glutamate receptors in neurons of the hypothalamic supraoptic nucleus. J. Neurophysiol. 78: 3428–3437, 1997. We studied the effects of activation of the metabotropic glutamate receptors on intrinsic currents of magnocellular neurons of the supraoptic nucleus (SON) with whole cell patch-clamp and conventional intracellular recordings in coronal slices (400 μm) of the rat hypothalamus. Trans-(±)-1-amino-1,3-cyclopentane dicarboxylic acid ( trans-ACPD, 10–100 μM), a broad-spectrum metabotropic glutamate re

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Maki, R., D. D. Cummings, and M. A. Dichter. "Frequency-dependent depression of excitatory synaptic transmission is independent of activation of MCPG-sensitive presynaptic metabotropic glutamate receptors in cultured hippocampal neurons." Journal of Neurophysiology 74, no. 4 (1995): 1671–74. http://dx.doi.org/10.1152/jn.1995.74.4.1671.

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1. A paired-pulse paradigm, and a high-frequency train followed by a test pulse, were used to investigate the possible role of presynaptic metabotropic glutamate receptors (mGluRs) in frequency-dependent modulation of the amplitude of excitatory post-synaptic currents (EPSCs). Paired whole cell patch-clamp recordings from monosynaptically connected hippocampal neurons maintained in very low-density cultures were performed, using the mGluR antagonist (RS)-alpha-methyl-4-carboxyphenylglycine (MCPG, 500 microM) and the mGluR agonist (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid [(1S,3R)-ACPD,

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Aniksztejn, L., M. Sciancalepore, Y. Ben Ari, and E. Cherubini. "Persistent current oscillations produced by activation of metabotropic glutamate receptors in immature rat CA3 hippocampal neurons." Journal of Neurophysiology 73, no. 4 (1995): 1422–29. http://dx.doi.org/10.1152/jn.1995.73.4.1422.

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1. The single-electrode voltage-clamp technique was used to study the effects of the metabotropic glutamate receptors (mGluRs) agonist 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD, ACPD, 3-10 microM) on CA3 hippocampal neurons during the 1st 10 days of postnatal (P) life and in adulthood. 2. Repeated applications of 1S,3R-ACPD, in the presence of tetrodotoxin (TTX, 1 microM), tetraethylammonium chloride (TEACl 10 mM), and CsCl (2 mM), induced in immature but not in adult neurons periodic inward currents (PICs) that persisted for several hours after the last application of the ag

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Chianca, Deoclecio A., Li-Hsien Lin, Deidre Nitschke Dragon, and William T. Talman. "NMDA receptors in nucleus tractus solitarii are linked to soluble guanylate cyclase." American Journal of Physiology-Heart and Circulatory Physiology 286, no. 4 (2004): H1521—H1527. http://dx.doi.org/10.1152/ajpheart.00236.2003.

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We sought to test the hypothesis that cardiovascular responses to activation of ionotropic, but not metabotropic, glutamate receptors in the nucleus tractus solitarii (NTS) depend on soluble guanylate cyclase (sGC) and that inhibition of sGC would attenuate baroreflex responses to changes in arterial pressure. In adult male Sprague-Dawley rats anesthetized with chloralose, the ionotropic receptor agonists N-methyl-d-aspartate (NMDA) and dl-α-amino-3-hydroxy-5-methylisoxazole-propionic acid (AMPA) and the metabotropic receptor agonist trans-dl-amino-1,3-cyclopentane-dicarboxylic acid (ACPD) wer

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Woodhall, Gavin, Christine E. Gee, Richard Robitaille, and Jean-Claude Lacaille. "Membrane Potential and Intracellular Ca2+ Oscillations Activated by mGluRs in Hippocampal Stratum Oriens/Alveus Interneurons." Journal of Neurophysiology 81, no. 1 (1999): 371–82. http://dx.doi.org/10.1152/jn.1999.81.1.371.

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Woodhall, Gavin, Christine E. Gee, Richard Robitaille, and Jean-Claude Lacaille. Membrane potential and intracellular Ca2+ oscillations activated by mGluRs in hippocampal stratum oriens/alveus interneurons. J. Neurophysiol. 81: 371–382, 1999. Metabotropic glutamate receptors (mGluRs) are expressed heterogeneously in hippocampal interneurons, and their signal transduction cascades remain largely unclear. We characterized an oscillatory response activated by the mGluR agonist 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) in hippocampal interneurons of stratum oriens-alveus (OA) wi

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Chen, H., F. D. Boudinot, C. K. Chu, H. M. Mcclure, and R. F. Schinazi. "Pharmacokinetics of (-)-beta-D-2-aminopurine dioxolane and (-)-beta-D-2-amino-6-chloropurine dioxolane and their antiviral metabolite (-)-beta-D-dioxolane guanine in rhesus monkeys." Antimicrobial Agents and Chemotherapy 40, no. 10 (1996): 2332–36. http://dx.doi.org/10.1128/aac.40.10.2332.

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(-)-beta-D-2-Aminopurine dioxolane (APD) and (-)-beta-D-2-amino-6-chloropurine dioxolane (ACPD) are recently synthesized dioxolanylpurine nucleoside derivatives being developed as potential prodrugs for the antiviral nucleoside analog (-)-beta-D-dioxolane guanine (DXG). In vitro, APD and ACPD are converted to DXG by xanthine oxidase and adenosine deaminase, respectively. The purpose of this study was to evaluate the preclinical pharmacokinetics of APD and ACPD and their potential for generating sustained levels of the parent nucleoside, DXG, in rhesus monkeys following oral administration. Bot

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Morsette, Delmore J., Hanna Sidorowicz, and Celia D. Sladek. "Role of metabotropic glutamate receptors in vasopressin and oxytocin release." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 281, no. 2 (2001): R452—R458. http://dx.doi.org/10.1152/ajpregu.2001.281.2.r452.

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The effect of metabotropic glutamate receptor (mGluR) activation on vasopressin (VP) and oxytocin (OT) release was evaluated using explants of the hypothalamoneurohypophysial system. (+/−)-1-Aminocyclopentane- trans-1,3-dicarboxylic acid (t-ACPD), an agonist at groups I and II mGluRs, increased VP and OT release in a concentration-dependent manner. A role for group I mGluRs in VP and OT release was demonstrated by the ability of a group I-specific mGluR antagonist, 1-aminoindan-1,5-idicarboxylic acid (AIDA), to block the effect of t-ACPD and the ability of a group I-specific agonist, ( R, S)-3

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Chinestra, P., L. Aniksztejn, D. Diabira, and Y. Ben-Ari. "(RS)-alpha-methyl-4-carboxyphenylglycine neither prevents induction of LTP nor antagonizes metabotropic glutamate receptors in CA1 hippocampal neurons." Journal of Neurophysiology 70, no. 6 (1993): 2684–89. http://dx.doi.org/10.1152/jn.1993.70.6.2684.

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1. The effects of the putative antagonist of metabotropic glutamate receptors (mGluR), (RS)-alpha-methyl-4-carboxyphenylglycine (MCPG), were investigated in CA1 hippocampal neurons using intracellular and extracellular recordings. 2. MCPG (0.5 mM) did not antagonize the characteristic block of the slow afterhyperpolarization and spike accomodation produced by the selective mGluR agonist, 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) (30 microM). 3. MCPG (0.5 mM) did not prevent the inward current produced by 1S,3R-ACPD (30 microM) [240 +/- 14 and 255 +/- 21 pA (mean +/- SD) in t

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Bowler, John R., and Nicola Bowler. "Theory of four-point alternating current potential drop measurements on conductive plates." Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences 463, no. 2079 (2007): 817–36. http://dx.doi.org/10.1098/rspa.2006.1791.

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Measurements of alternating current potential drop (ACPD) made at the surface of a conductive plate can be used to determine, non-destructively, the parameters of the plate such as its thickness, electrical conductivity and linear effective magnetic permeability. In order to invert the measured potential drop to yield values for these parameters, a theoretical model is needed. In this work, closed form analytical expressions are derived for the ACPD measured between the two voltage electrodes of a four-point probe. Alternating current is injected and extracted by two current electrodes. The pr

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Sayer, R. J., P. C. Schwindt, and W. E. Crill. "Metabotropic glutamate receptor-mediated suppression of L-type calcium current in acutely isolated neocortical neurons." Journal of Neurophysiology 68, no. 3 (1992): 833–42. http://dx.doi.org/10.1152/jn.1992.68.3.833.

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1. The effects of metabotropic glutamate receptor (mGluR) stimulation on whole-cell Ca2+ currents were studied in pyramidal neurons isolated from the dorsal frontoparietal neocortex of rat. The selective mGluR agonist cis-(+/-)-1-aminocyclopentane-1,3-dicarboxylic acid [trans-ACPD (100 microM)] suppressed the peak high-threshold Ca2+ current by 21 +/- 1.7% (mean +/- SE) in 40 of 43 cells from 10- to 21-day-old rats. Consistent with previous findings for mGluR, glutamate, quisqualate, and ibotenate [but not alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)] reduced the Ca2+ curren

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Svirskis, Gytis, and Jørn Hounsgaard. "Transmitter Regulation of Plateau Properties in Turtle Motoneurons." Journal of Neurophysiology 79, no. 1 (1998): 45–50. http://dx.doi.org/10.1152/jn.1998.79.1.45.

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Svirskis, Gytis and Jørn Hounsgaard. Transmitter regulation of plateau properties in turtle motoneurons. J. Neurophysiol. 79: 45–50, 1998. In motoneurons, generation of plateau potentials is promoted by modulators that block potassium channels. In voltage-clamp experiments with triangular voltage ramp commands, we show that cis-(±)-1-aminocyclopentane-1,3-dicarboxylic acid ( cis-ACPD) and muscarine promote the generation of plateau potentials by increasing the dihydropyridine sensitive inward current, by increasing the input resistance, and by depolarizing the resting membrane potential. Type

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