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Zeitschriftenartikel zum Thema „Adverse side effects“

Autor: Grafiati

Veröffentlicht am 17. November 2023

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1

Hollister, J., und Suzanne Bowyer. „Adverse Side Effects of Corticosteroids“. Seminars in Respiratory and Critical Care Medicine 8, Nr. 04 (April 1987): 400–405. http://dx.doi.org/10.1055/s-2007-1012680.

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FLAKER, GREG C., und DOUGLAS CHAPMAN. „Adverse Side Effects Associated with Mexiletine“. Clinical Progress in Electrophysiology and Pacing 4, Nr. 6 (Dezember 1986): 602–7. http://dx.doi.org/10.1111/j.1540-8167.1986.tb01740.x.

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3

Huang, Liang-Chin, Xiaogang Wu und Jake Y. Chen. „Predicting adverse side effects of drugs“. BMC Genomics 12, Suppl 5 (2011): S11. http://dx.doi.org/10.1186/1471-2164-12-s5-s11.

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4

Rowe, Jonathan A., Matthew G. Hattenhauer und David C. Herman. „Adverse Side Effects Associated With Latanoprost“. American Journal of Ophthalmology 124, Nr. 5 (November 1997): 683–85. http://dx.doi.org/10.1016/s0002-9394(14)70907-9.

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5

Robertson, Deborah. „Side effects and adverse drug reactions“. Nurse Prescribing 15, Nr. 10 (02.10.2017): 512–14. http://dx.doi.org/10.12968/npre.2017.15.10.512.

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Pichler, W. J. „Adverse side-effects to biological agents“. Allergy 61, Nr. 8 (August 2006): 912–20. http://dx.doi.org/10.1111/j.1398-9995.2006.01058.x.

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7

Beaumont, G., S. Kasper, J. O'Hanlon und J. Mendlewicz. „Antidepressant side effects and adverse reactions“. Depression 2, Nr. 3 (1994): 138–44. http://dx.doi.org/10.1002/depr.3050020305.

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8

M.C. Besag, Frank. „Editorial (Adverse Effects, Adverse Events and Side-Effects: Does the Terminology Matter?“ Current Drug Safety 6, Nr. 1 (01.02.2011): 1–2. http://dx.doi.org/10.2174/157488611794479964.

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9

Cookson, John. „Side-effects of Antidepressants“. British Journal of Psychiatry 163, S20 (Juli 1993): 20–24. http://dx.doi.org/10.1192/s0007125000292325.

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The adverse effects of antidepressants include their pharmacological side-effects, toxic effects, interactions with other drugs, and symptoms occurring during their withdrawal. The focus of this paper is on the pharmacological side-effects.

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Kovalenko, E. I., I. B. Kononenko, A. V. Snegovoi, O. P. Grebennikova und L. V. Manzyuk. „Adverse effects of adjuvant endocrine therapy“. Medical Council, Nr. 10 (19.07.2018): 64–69. http://dx.doi.org/10.21518/2079-701x-2018-10-64-69.

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Hormonal therapy is a highly effective and well tolerable treatment of hormone-responsive breast cancer. However, it has some side effects that can affect quality of life and lead to treatment discontinuation. Common side effects of tamoxifen and aromatase inhibitors are discussed in this article: menopausal, gynecological symptoms, cardiovascular and musculoskeletal adverse events. Some of them are preventable and manageable. In order to maintain good quality of life during treatment the oncologists should pay more attention to the side effects that lead to it’s deterioration and not be too anxious about insignificant ones.

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Brown, RB, J. Levin und A. Morris. „Adverse effects of antibiotics“. Journal of the American Podiatric Medical Association 79, Nr. 10 (01.10.1989): 500–504. http://dx.doi.org/10.7547/87507315-79-10-500.

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Adverse reactions to antibiotics comprise a number of classes of reactions, including toxicity, side effects, and allergy. Each one of these differs in its implication for treatment of the patient. The authors discuss some of the more common and unusual reactions to antibiotics frequently used in the practice of podiatric medicine.

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ESLAMI, Behnaz, Mehdi HABIBZADEH MOTLAGH, Zahra REZAEI, Mohammad ESLAMI und Mohammad AMIN AMINI. „UNSUPERVISED DYNAMIC TOPIC MODEL FOR EXTRACTING ADVERSE DRUG REACTION FROM HEALTH FORUMS“. Applied Computer Science 16, Nr. 1 (30.03.2020): 41–59. http://dx.doi.org/10.35784/acs-2020-04.

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The relationship between drug and its side effects has been outlined in two websites: Sider and WebMD. The aim of this study was to find the association between drug and its side effects. We compared the reports of typical users of a web site called: "Ask a patient" website with reported drug side effects in reference sites such as Sider and WebMD. In addition, the typical users' comments on highly-commented drugs (Neurotic drugs, Anti-Pregnancy drugs and Gastrointestinal drugs) were analyzed, using deep learning method. To this end, typical users' comments on drugs' side effects, during last decades, were collected from the website “Ask a patient”. Then, the data on drugs were classified based on deep learning model (HAN) and the drugs' side effect. And the main topics of side effects for each group of drugs were identified and reported, through Sider and WebMD websites. Our model demonstrates its ability to accurately describe and label side effects in a temporal text corpus by a deep learning classifier which is shown to be an effective method to precisely discover the association between drugs and their side effects. Moreover, this model has the capability to immediately locate information in reference sites to recognize the side effect of new drugs, applicable for drug companies. This study suggests that the sensitivity of internet users and the diverse scientific findings are for the benefit of dis¬tinct detection of adverse effects of drugs, and deep learning would facilitate it.

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Attardo, Silvia, Olimpia Musumeci, Daniele Velardo und Antonio Toscano. „Statins Neuromuscular Adverse Effects“. International Journal of Molecular Sciences 23, Nr. 15 (28.07.2022): 8364. http://dx.doi.org/10.3390/ijms23158364.

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Statins are drugs widely prescribed in high-risk patients for cerebrovascular or cardiovascular diseases and are, usually, safe and well tolerated. However, these drugs sometimes may cause neuromuscular side effects that represent about two-third of all adverse events. Muscle-related adverse events include cramps, myalgia, weakness, immune-mediated necrotizing myopathy and, more rarely, rhabdomyolysis. Moreover, they may lead to peripheral neuropathy and induce or unmask a preexisting neuromuscular junction dysfunction. A clinical follow up of patients assuming statins could reveal early side effects that may cause neuromuscular damage and suggest how to better modulate their use. In fact, statin dechallenge or cessation, or the alternative use of other lipid-lowering agents, can avoid adverse events. This review summarizes the current knowledge on statin-associated neuromuscular adverse effects, diagnosis, and management. It is conceivable that the incidence of neuromuscular complications will increase because, nowadays, use of statins is even more diffused than in the past. On this purpose, it is expected that pharmacogenomic and environmental studies will help to timely predict neuromuscular complications due to statin exposure, leading to a more personalized therapeutic approach.

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Korah, Mejo C., Junaid Rahman Pv, R. Rajeswari, Ahana Behanan, Elizabeth Phoeba Paul und T. Sivakumar. „ADVERSE EFFECTS AND SIDE EFFECTS ON VITAMIN THERAPY: A REVIEW“. Asian Journal of Pharmaceutical and Clinical Research 10, Nr. 5 (01.05.2017): 19. http://dx.doi.org/10.22159/ajpcr.2017.v10i5.17014.

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Vitamins are essential to our day to day life. Its shortage in our body can cause many disorders, decreased enzyme activities also affects the genetic factors. Vitamins should be supplied through the diet in the required amount. If it is not supplied properly, vitamin tablets will be prescribed. And also vitamin tablets are the co-medication for therapies like anticancer, anti tubercular, anti viral anti HIV treatments. Many news papers reported that vitamin therapies are causing major health problems like nephro/ urolithiasis, it can increases mortality rates in smokers by increasing the risk of lung cancer, it can cause abortion when it is taken during pregnancy. Thus here we reviewed the adverse effects of vitamin therapy from various reported cases, books, instructions provided from various health organizations and also news papers and magazines. It can help health professionals to control and monitor the vitamin therapies and make awareness about the adverse effects and possible side effects of regular vitamin uptake to society.

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Pepperell, Roger J. „Beneficial and adverse side‐effects of hormonal contraception“. Medical Journal of Australia 144, Nr. 4 (Februar 1986): 169–70. http://dx.doi.org/10.5694/j.1326-5377.1986.tb128348.x.

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Pfiffner, Linda J., und George J. DuPaul. „Possible Adverse Side Effects of School Behavioral Interventions“. ADHD Report 26, Nr. 1 (Februar 2018): 10–13. http://dx.doi.org/10.1521/adhd.2018.26.1.10.

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Stojic-Vukanic, Zorica, Nevena Arsenovic-Ranin, Jelena Antic-Stankovic und Marina Milenkovic. „Adverse side-effects of biological agents: Hypersensitivity reactions“. Arhiv za farmaciju 64, Nr. 6 (2014): 457–72. http://dx.doi.org/10.5937/arhfarm1406457s.

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18

O'Donnell, James. „Adverse Effects of Corticosteroids“. Journal of Pharmacy Practice 2, Nr. 4 (August 1989): 256–66. http://dx.doi.org/10.1177/089719008900200410.

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Currently, adrenal corticosteroids (steroids) are used for a wide variety of clinical conditions. Steroids are known to cause many pathologic effects, including chemically induced diabetes, psychological changes, musculoskeletal (including avascular) necrosis, suppression of the adrenals, and significant effects on the eye. Considering the important risk factors involved with the use of these toxic, yet essential medications, pharmacists have a serious responsibility to monitor their use for indications, dosage, interactions, and side effects.

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Carter, Barry L., Jerold C. Woodhead, Katherine J. Cole und Gary Milavetz. „Gastrointestinal Side Effects with Erythromycin Preparations“. Drug Intelligence & Clinical Pharmacy 21, Nr. 9 (September 1987): 734–38. http://dx.doi.org/10.1177/106002808702100914.

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This study was designed to determine the incidence and severity of gastrointestinal (GI) side effects in patients taking erythromycin. More patients complained of GI side effects with the enteric-coated tablet (70.8 percent) than with the stearate (51.4 percent) or the ethylsuccinate (48.9 percent) salts. The enteric-coated tablet was associated with a higher incidence of individual adverse reactions; more patients discontinued it because of adverse GI effects. These data demonstrate a high incidence of GI side effects to erythromycin. Additionally, GI side-effect incidence appears to be higher with the enteric-coated tablet.

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Moreira, Bernardo, Sigride Thomé-Souza und Kette Valente. „Late side-effects of valproate and lamotrigine“. Journal of Epilepsy and Clinical Neurophysiology 13, Nr. 4 (Dezember 2007): 187–89. http://dx.doi.org/10.1590/s1676-26492007000400008.

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Lamotrigine (LTG) is a generally well-tolerated antiepileptic drug with broad-spectrum efficacy in several forms of partial and generalized epilepsy. Adverse effects of lamotrigine are usually associated with introduction and titration. This risk increases in children and in the co-medication with valproate. Herein, we report four patients with late adverse-effects, under the co-medication valproate and LTG, not related to drug introduction or titration. This study demonstrates that late side-effects without apparent etiology in children, adolescents and adults in chronic use of LTG, especially when associated to VPA, led to a diagnostic investigation, sometimes invasive. It must be emphasized that, due to the excellent seizure control, the authors opted for drug decrease instead of drug withdrawal, as previously done. Studies on late adverse effects are scarce, but physicians must be aware of these risks.

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Steinhart, Yael, Ziv Carmon und Yaacov Trope. „Warnings of Adverse Side Effects Can Backfire Over Time“. Psychological Science 24, Nr. 9 (02.08.2013): 1842–47. http://dx.doi.org/10.1177/0956797613478948.

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22

Valejo Coelho, Margarida Moura, und Margarida Apetato. „The dark side of the light: Phototherapy adverse effects“. Clinics in Dermatology 34, Nr. 5 (September 2016): 556–62. http://dx.doi.org/10.1016/j.clindermatol.2016.05.005.

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23

Aubin, François, Franck Carbonnel und Daniel Wendling. „The complexity of adverse side-effects to biological agents“. Journal of Crohn's and Colitis 7, Nr. 4 (Mai 2013): 257–62. http://dx.doi.org/10.1016/j.crohns.2012.06.024.

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24

Cheon, Dae Young, und Sang-Ho Jo. „Adverse effects of statin therapy and their treatment“. Cardiovascular Prevention and Pharmacotherapy 4, Nr. 1 (31.01.2022): 1–6. http://dx.doi.org/10.36011/cpp.2022.4.e4.

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Statins are one of the most widely used drugs worldwide as first-line drugs for the treatment of hyperlipidemia and the prevention and treatment of cardiovascular diseases. Most of the side effects of statins are known to be mild, and mainly hepatotoxicity and various muscle symptoms are known. Recently, there have been studies on concerns about an increase in the incidence of diabetes after using statins, but it was found that the benefits sufficiently outweigh the risk of side effects. Therefore, the use of statins in the appropriate group should be actively performed, and it seems that the side effects can be prevented through close physical observation and appropriate examination.

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Chen, Y. H., Y. T. Shih, C. S. Chien und C. S. Tsai. „Predicting adverse drug effects: A heterogeneous graph convolution network with a multi-layer perceptron approach“. PLOS ONE 17, Nr. 12 (14.12.2022): e0266435. http://dx.doi.org/10.1371/journal.pone.0266435.

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We apply a heterogeneous graph convolution network (GCN) combined with a multi-layer perceptron (MLP) denoted by GCNMLP to explore the potential side effects of drugs. Here the SIDER, OFFSIDERS, and FAERS are used as the datasets. We integrate the drug information with similar characteristics from the datasets of known drugs and side effect networks. The heterogeneous graph networks explore the potential side effects of drugs by inferring the relationship between similar drugs and related side effects. This novel in silico method will shorten the time spent in uncovering the unseen side effects within routine drug prescriptions while highlighting the relevance of exploring drug mechanisms from well-documented drugs. In our experiments, we inquire about the drugs Vancomycin, Amlodipine, Cisplatin, and Glimepiride from a trained model, where the parameters are acquired from the dataset SIDER after training. Our results show that the performance of the GCNMLP on these three datasets is superior to the non-negative matrix factorization method (NMF) and some well-known machine learning methods with respect to various evaluation scales. Moreover, new side effects of drugs can be obtained using the GCNMLP.

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G, Siddesha, Justina M. Steefan und A. Naveen. „Adverse Effects of Antipsychotic Drugs - A Review“. International Journal of Research and Review 10, Nr. 9 (15.09.2023): 153–56. http://dx.doi.org/10.52403/ijrr.20230916.

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Antipsychotic drugs which are also known as Neuroleptics are group of psychotropic drugs or psychopharmacological agents1 that are primarily used to manage psychoses including delusions, hallucinations, paranoia, or disordered thought. Besides their antipsychotic action, they had been reported to have some adverse effects which can be seen in Cardiovascular system, Metabolic system, Skeletal and Muscular system, Cognitive and Emotional side effects, and Sexual dysfunction. These adverse effects were mainly observed when they used for longer duration or taken in larger doses or with sudden change in their dose. Keywords: Antipsychotic drugs, Adverse events, Side effects, Extrapyramidal symptoms

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Licht, C. „Rare adverse effects of Electro Convulsive Therapy“. European Psychiatry 66, S1 (März 2023): S1017—S1018. http://dx.doi.org/10.1192/j.eurpsy.2023.2161.

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IntroductionECT’s most common side effects are headache, memory impairment, and cardiovascular changes [1]. We report the unusual case of unilateral eyelid swelling and cheek flushing as a side effect of ECT in a depressed but otherwise healthy patient.ObjectivesThe patient is a 53-year-old woman with a recurrent depressive disorder for 15 years with a current major depressive episode without psychotic symptoms. With therapy resistance to mirtazapine (60 mg/d) and lithium (675 mg/d; 0.75 mmol/l), an ECT series with a total of seven sessions were performed. Treatment was performed with right unilateral electrode placement according to d’Elia (RUL).MethodsAfter the first session (Thymatron IV; energy: 20%; pulse width: 0.5; EEG: 45 s), marked hemifacial erythema and supraorbital lid swelling on the right side were evident. After each of the total seven sessions with adequate seizures in the EEG between 45 to 68 s, hemifacial erythema and supraorbital eyelid swelling were evident on the right side.ResultsBoth supraorbital eyelid edema occurred immediately after seizure onset, and hemifacial erythema resolved spontaneously and entirely within 10 minutes after the termination of the respective seizure.ConclusionsThe right side of the face appeared normal before ECT and had no injuries or abnormalities. Trauma, allergic reactions to the anesthetic, or complications of manual ventilation were excluded. In the literature, only one case report with supraorbital eyelid edema [2] and one case report with hemifacial redness of the face [3] after ECT have been described so far. We evaluate the eyelid edema and erythema that occurred in our case as isolated benign complications, most likely due to autonomic activation of facial nerves due to electrical stimulation in RUL.Disclosure of InterestNone Declared

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Cretu, Ioana, Bogdan Cretu, Catalin Cirstoiu, Adrian Cursaru, Mihaela Milicescu, Mihai Bojinca und Ruxandra Ionescu. „Rheumatological Adverse Events Following Immunotherapy for Cancer“. Medicina 58, Nr. 1 (08.01.2022): 94. http://dx.doi.org/10.3390/medicina58010094.

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Background and Objectives: The occurrence of rheumatological side effects in a patient after receiving immunotherapy for cancer is becoming increasingly common. Oncologists often fail to diagnose and refer affected patients to rheumatologists. This paper presents the various rheumatological adverse events that occur after immunotherapy in patients as well as their treatment and evolution. Materials and Methods: A total of 36 patients were monitored between November 2018 and March 2020. The oncologist monitoring the immunotherapy-treated patients identified the occurrence of musculoskeletal side effects. The grading of toxicities was performed by both the oncologist and the rheumatologist using common terminology criteria for adverse events (CTCAE). Rheumatological treatment was administered, and for some patients, immunotherapy was discontinued. Results: The clinical presentations of the patients varied. Mild side effects (grade 1–2) were reported in a higher proportion than severe side effects (grade 3–5). Therefore, thirty-one patients had mild-to-moderate side effects, and five patients had severe side effects. Adverse reactions occurred, on average, 10 weeks after the initiation of immunotherapy; this indicated that the severity of the toxicity was dose dependent. Patients were treated with NSAIDs or prednisone, depending on the severity of the side effects, and for patients with severe manifestations, immunotherapy was discontinued. The remission of rheumatic manifestations varied depending on the grade of the manifestations. Conclusions: The clinical, biological, and ultrasound presentations of the patients with adverse events followed by cancer treatments differed from classic rheumatological manifestations. Thorough examinations of these patients by both oncologists and rheumatologists are needed in order to correctly diagnose and treat rheumatological adverse events. Multiple studies that include a larger number of participants are needed in order to better understand the pathogenesis and clinical evolution of these patients under different treatment conditions.

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Mercadante, Sebastiano. „Opioid Analgesics Adverse Effects: The Other Side of the Coin“. Current Pharmaceutical Design 25, Nr. 30 (13.11.2019): 3197–202. http://dx.doi.org/10.2174/1381612825666190717152226.

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Background: Opioids are the cornerstone of the management of cancer pain. However, the development of adverse effects may compromise the opioid response. They include nausea and vomiting, constipation, drowsiness, sleep disorders, cognitive dysfunction, myoclonus, pruritus, dysuria, dependence and the development of aberrant behaviors, respiratory depression, and some endocrine responses. Methods: The goal of this paper is to identify the most common opioid-related adverse effects, their pathophysiology, and proposing the possible treatments. This narrative review will describe how these adverse effects may develop and how to prevent or to treat. Conclusion: Intensity of adverse effects tend to decrease with continuous use. However, they may be persistent and may require symptomatic treatment or more complex treatment including alternative strategies for pain management.

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Ziff, M. F. „Documented Clinical Side-Effects to Dental Amalgam“. Advances in Dental Research 6, Nr. 1 (September 1992): 131–34. http://dx.doi.org/10.1177/08959374920060010601.

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Since all dental restorative materials are foreign substances, their potential for producing adverse health effects is determined by their relative toxicity and bioavailability, as well as by host susceptibility. Adverse health effects to dental restoratives may be local in the oral cavity or systemic, depending on the ability of released components to enter the body and, if so, on their rate of absorption. The medical scientific community is now in general agreement that patients with dental amalgam fillings are chronically exposed to mercury, that the average daily absorption of mercury from dental amalgam is from 3 to 17 micrograms per day, and that the amalgam mercury absorption averages 1.25-6.5 times the average mercury absorption from dietary sources (World Health Organization, 1991). The health significance of this chronic mercury exposure is now being investigated by several medical research groups.

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Xiang, Elaine, Jian Ni, Brett Glotzbecker, Jacob Laubach, Robert Soiffer und Anne M. McDonnell. „Evaluating the adverse effects of melphalan formulations“. Journal of Oncology Pharmacy Practice 25, Nr. 7 (18.10.2018): 1631–37. http://dx.doi.org/10.1177/1078155218804042.

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Introduction For multiple myeloma patients who respond to primary therapy, autologous hematopoietic stem cell transplant (HSCT) is considered standard of care with high-dose melphalan for transplant candidates. There are now two different melphalan formulations available, including a propylene glycol containing (PG-MEL) product and a propylene glycol-free (PG-free MEL) product. Although considered bioequivalent, there remains limited literature directly evaluating the adverse events between the two agents. We seek to assess the tolerability and severity of side effects between the two formulations in a real-life practice setting. Methods A retrospective, descriptive analysis was conducted of multiple myeloma patients who received autologous stem cell conditioning with either melphalan formulation when dosed at 100 mg/m2/dose for two consecutive doses. The primary outcome was the assessment of tolerability and severity of side effects. Tolerability was split into four major categories including hematologic toxicity, gastrointestinal toxicity, renal toxicity, and highest recorded mucositis grade. Results There were a total of 78 patients who received a melphalan preparation during the study. The median time to myeloablation and neutrophil engraftment was five and seven days post-HSCT, respectively, for all patients. Patients who received PG-free MEL were less likely to develop mucositis, with 22 (56%) reported highest grade 0, defined by World Health Organization oral toxicity scale, compared to those who received PG-MEL (33%), p = 0.04. Conclusion There were minimal differences in tolerability or side effects observed between PG-free MEL and PG-MEL. These data may assist in better understanding the anticipated adverse effects of a high-dose melphalan conditioning therapy.

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Gherghel, Doina. „Systemic side effects of ocular medication – 4“. Optician 2020, Nr. 11 (November 2020): 8393–1. http://dx.doi.org/10.12968/opti.2020.11.8393.

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Dr Doina Gherghel concludes her review of the adverse effects of ophthalmic drugs with a further look at intravitreal drugs and those used during surgical procedures (C 76604, one distance learning CET point suitable for optometrists and therapeutic optometrists)

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Becker, Philipp, Andreas Pabst, Oliver Thiele, John Rudat und Richard Werkmeister. „Adverse side effects with hyaluronic acid fillers: A case report“. Advances in Oral and Maxillofacial Surgery 2 (April 2021): 100034. http://dx.doi.org/10.1016/j.adoms.2021.100034.

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Nagy, Gabriella, Katalin Lukács, Ágnes Sziray, Katalin Fazekas, Ágnes Florián, László Tamási und Zsuzsánna Károlyi. „Adverse events during biological therapy – focusing on dermatological side-effects“. Orvosi Hetilap 152, Nr. 6 (Februar 2011): 212–20. http://dx.doi.org/10.1556/oh.2011.28987.

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Biological response modifiers, especially tumour necrosis factor inhibitors have been proved to be very effective in the treatment of various immune mediated rheumatological, gastroenterological and dermatological diseases in the last 15 years. With their increasing use, the incidence of their adverse effects are more precisely defined. The aim of this cohort study was to analyse the adverse effects occurred within the study period in patients receiving biological therapy for rheumatological and dermatological autoimmune diseases. Methods: 324 patients within a 3 years study period were treated with biological response modifiers (adalimumab: 92, etanercept: 107, infliximab: 125). The primary diagnoses were rheumotoid arthritis (n = 174), ankylosing spondylitis (n = 60), psoriatic arthritis (n = 11), and psoriasis vulgaris (79). Results: Hypersensitive reactions were observed in 11 of the patients (3.4%), 7 of which were serious and needed treatment termination. Infections constituted the majority of side effects, which were localised to skin in 10 (3.1%) and to respiratory tract in 9 (2.8%). However, most of these were mild or moderate reactions. Malignant skin tumour developed in 1 case (0.3%) only. Drug induced inflammatory disorders occurred in some cases: onset of new psoriasis was observed in 1 and flares of the existing disease were detected in additional three. Lichenoid exanthema developed in one. (n = 5, 1.5%) Conclusion: The use of TNF-α blockers may provoke a broad spectrum of dermatological side effects. Our results suggest that the majority of these are infectious and inflammatory disorders, the latter may relatively often appear as drug induced psoriasis. The occurrence of malignancies was very low in our series. Orv. Hetil., 2011, 152, 212–220.

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Cay, Serkan, Ozcan Ozeke, Firat Ozcan, Serkan Topaloglu und Dursun Aras. „Side effects of the wearable defibrillator, not adverse, even useful“. Pacing and Clinical Electrophysiology 42, Nr. 3 (30.12.2018): 388. http://dx.doi.org/10.1111/pace.13586.

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Allen, Cheryl A., und Julius R. Ivester. „Ketamine for Pain Management—Side Effects & Potential Adverse Events“. Pain Management Nursing 18, Nr. 6 (Dezember 2017): 372–77. http://dx.doi.org/10.1016/j.pmn.2017.05.006.

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Bradbury, Jane. „UK survey of adverse neuropsychiatric side-effects of mefloquine published“. Lancet 348, Nr. 9028 (September 1996): 672. http://dx.doi.org/10.1016/s0140-6736(05)65081-7.

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Berkane, Nadia, Patrick Carlier, Lieve Verstraete, Emmanuelle Mathieu, Nazbanou Heim und Serge Uzan. „Fetal toxicity of valsartan and possible reversible adverse side effects“. Birth Defects Research Part A: Clinical and Molecular Teratology 70, Nr. 8 (August 2004): 547–49. http://dx.doi.org/10.1002/bdra.20047.

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Kirsch, I., A. R. Ness und K. M. Appleton. „Treatments for depression: Side-effects, adverse events and health risks“. Journal of Affective Disorders 259 (Dezember 2019): 38–39. http://dx.doi.org/10.1016/j.jad.2019.08.018.

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Ryu, Hyewon. „Management of the adverse effects of targeted therapy for cancer“. Journal of the Korean Medical Association 66, Nr. 2 (10.02.2023): 105–11. http://dx.doi.org/10.5124/jkma.2023.66.2.105.

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Background: Advances in genomics and molecular biology over the past 20 years have resulted in numerous approved molecular targeted cancer therapies. The two main approaches for targeted cancer therapy are monoclonal antibodies and small molecules. Targeted therapy is expected to exert few side effects, but a new class of toxicities has been reported. Thus, the classical chemotherapy-induced toxicities of alopecia, myelosuppression, mucositis, nausea, and vomiting have been replaced in patients receiving targeted therapies by dermatologic, cardiovascular, gastrointestinal, endocrine, ocular, and pulmonary toxicities, and infusion reactions.Current Concepts: Targeted therapy toxicities vary, but common side effects include skin rash, diarrhea, and stomatitis. Most of these side effects are mild and can be prevented and treated. Rare and dangerous side effects, including pneumonitis, cardiotoxicities, and infusion reactions, can also be induced by targeted therapies. In most cases, toxicities are low grade (grade ≤2) and can be treated effectively, but in some cases, they can be fatal without appropriate intervention. Symptoms can be nonspecific, rendering identification of early symptoms challenging. Physicians should thus be aware of these side effects and manage toxicities appropriately.Discussion and Conclusion: The side effects of targeted therapy exert a critical impact on survival and quality of life. Most patients receiving targeted therapy need help to prevent and relieve toxicities. Management of the toxicities of targeted therapy involves patient monitoring, adjusting therapeutic dose or frequency, and providing supportive care. Serious side effects require early detection and prompt intervention, including discontinuation of targeted therapy and the use of corticosteroids.

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Xu, Hongzhang, Aaron Tang und Jamie Pittock. „The dark side of ambition: side-effects of China’s climate policy“. Environmental Research Letters 16, Nr. 11 (01.11.2021): 111001. http://dx.doi.org/10.1088/1748-9326/ac30bf.

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Abstract China’s latest commitments to the Paris Agreement have attracted great attention. Scholars have questioned the feasibility of China’s pledges to peak emissions before 2030 and achieve carbon neutrality by 2060. To achieve these goals, China has resorted to extreme emissions reduction actions. However, side-effects of China’s climate ambition have been largely overlooked. An intersectional and just transitions perspective is critical to examine limits and trade-offs for broad societal goals. This paper outlines five policy approaches that can help limit adverse side-effects and unlock broader social benefits.

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Sarde, Atharva, Mayur Badgujar, Gargee Athayle und Prof Shilpa Sondkar. „Predictive Analysis of Adverse Drug effects using Machine Learning“. International Journal for Research in Applied Science and Engineering Technology 10, Nr. 12 (31.12.2022): 868–75. http://dx.doi.org/10.22214/ijraset.2022.48058.

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Abstract: The objective of this work is to develop machine learning (ML) methods that can accurately predict adverse drug reactions (ADRs) using databases like SIDER (Side Effect Research) and OFFSIDES (Government medical records). In this paper, three Machine Learning algorithms SVM (Support Vector Machine), Random Forest, and Gradient boosted trees are implemented on the datasets to predict various disorders caused due to adverse effects, and the performance is evaluated based on performance metrics such as average precision, recall, accuracy, f1 binary, f1 macro, and f1 micro. Finally, the two datasets were merged to understand and compare the performance of a combined dataset to a single dataset.

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Kallistratos, Manolis S., Andreas Pittaras, Iakovos Theodoulidis, Charris Grassos, Leonidas E. Poulimenos und Athanasios J. Manolis. „Adverse Effects of Mineralocorticoid Receptor Antagonist Administration“. Current Pharmaceutical Design 24, Nr. 46 (26.04.2019): 5537–41. http://dx.doi.org/10.2174/1381612825666190222144359.

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Background: Mineralocorticoid receptor antagonists consist of a class of drugs with pleiotropic beneficial effects in several cardiovascular diseases. However, physicians frequently overlook their use due to the adverse effects of such agents. Objectives: To determine the adverse effects of mineralocorticoid receptor antagonists and to suggest clinically meaningful options. We present data on the two most administered agents of this class: spironolactone and eplerenone. Method: We conducted an in-depth review of the existing international literature to draft a mini review about the mineralocorticoid receptor antagonists-related side effects. Result: Mineralocorticoid receptor antagonists are associated with increased risk of hyperkalemia and acute deterioration of renal function. Of note, these adverse effects are dose-dependent, more common during the initial period of treatment, and are usually reversed after the withdrawal of therapy. Sex-related adverse events are noted mainly in spironolactone while switching to eplerenone could attenuate those. Conclusion: Mineralocorticoid receptor antagonists therapy is significantly limited due to their side effects. The development of novel non-steroidal mineralocorticoid receptor antagonists could substantially widen the use of such agents.

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Patanè, Federico Giuseppe, Aldo Liberto, Andreana Nicoletta Maria Maglitto, Pasquale Malandrino, Massimiliano Esposito, Francesco Amico, Giuseppe Cocimano et al. „Nandrolone Decanoate: Use, Abuse and Side Effects“. Medicina 56, Nr. 11 (11.11.2020): 606. http://dx.doi.org/10.3390/medicina56110606.

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Background and Objectives: Androgens play a significant role in the development of male reproductive organs. The clinical use of synthetic testosterone derivatives, such as nandrolone, is focused on maximizing the anabolic effects and minimizing the androgenic ones. Class II anabolic androgenic steroids (AAS), including nandrolone, are rapidly becoming a widespread group of drugs used both clinically and illicitly. The illicit use of AAS is diffused among adolescent and bodybuilders because of their anabolic proprieties and their capacity to increase tolerance to exercise. This systematic review aims to focus on side effects related to illicit AAS abuse, evaluating the scientific literature in order to underline the most frequent side effects on AAS abusers’ bodies. Materials and Methods: A systematic review of the scientific literature was performed using the PubMed database and the keywords “nandrolone decanoate”. The inclusion criteria for articles or abstracts were English language and the presence of the following words: “abuse” or “adverse effects”. After applying the exclusion and inclusion criteria, from a total of 766 articles, only 148 were considered eligible for the study. Results: The most reported adverse effects (found in more than 5% of the studies) were endocrine effects (18 studies, 42%), such as virilization, gynecomastia, hormonal disorders, dyslipidemia, genital alterations, and infertility; cardiovascular dysfunctions (six studies, 14%) such as vascular damage, coagulation disorders, and arteriosus hypertension; skin disorders (five studies, 12%) such as pricking, acne, and skin spots; psychiatric and mood disorders (four studies, 9%) such as aggressiveness, sleep disorders and anxiety; musculoskeletal disorders (two studies, 5%), excretory disorders (two studies, 5%), and gastrointestinal disorders (two studies, 5%). Conclusions: Based on the result of our study, the most common adverse effects secondary to the abuse of nandrolone decanoate (ND) involve the endocrine, cardiovascular, skin, and psychiatric systems. These data could prove useful to healthcare professionals in both sports and clinical settings.

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Baldwin, David, und Andrew Mayers. „Sexual side-effects of antidepressant and antipsychotic drugs“. Advances in Psychiatric Treatment 9, Nr. 3 (Mai 2003): 202–10. http://dx.doi.org/10.1192/apt.9.3.202.

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Adequate sexual expression is essential to many human relationships and provides a sense of physical, psychological and social well-being. Epidemiological and clinical studies show that depression and schizophrenia are associated with impairment of sexual function and satisfaction, even in untreated patients. Most antidepressant and antipsychotic drugs have adverse sexual effects but it is difficult accurately to identify the incidence of treatment-emergent dysfunction, as disturbances can be reliably detected only from systematic enquiries made at baseline and during treatment. Growing awareness of the adverse effects of psychotropic drugs has led to attempts to use adjuvants or substitute treatments to resolve sexual dysfunction. More studies of the effects of antidepressant and antipsychotic drugs on sexual function are needed.

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Benyamin, Ramsin. „Opioid Complications and Side Effects“. Pain Physician 2s;11, Nr. 3;2s (14.03.2008): S105—S120. http://dx.doi.org/10.36076/ppj.2008/11/s105.

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Medications which bind to opioid receptors are increasingly being prescribed for the treatment of multiple and diverse chronic painful conditions. Their use for acute pain or terminal pain is well accepted. Their role in the long-term treatment of chronic noncancer pain is, however, controversial for many reasons. One of the primary reasons is the well-known phenomenon of psychological addiction that can occur with the use of these medications. Abuse and diversion of these medications is a growing problem as the availability of these medications increases and this public health issue confounds their clinical utility. Also, the extent of their efficacy in the treatment of pain when utilized on a chronic basis has not been definitively proven. Lastly, the role of opioids in the treatment of chronic pain is also influenced by the fact that these potent analgesics are associated with a significant number of side effects and complications. It is these phenomena that are the focus of this review. Common side effects of opioid administration include sedation, dizziness, nausea, vomiting, constipation, physical dependence, tolerance, and respiratory depression. Physical dependence and addiction are clinical concerns that may prevent proper prescribing and in turn inadequate pain management. Less common side effects may include delayed gastric emptying, hyperalgesia, immunologic and hormonal dysfunction, muscle rigidity, and myoclonus. The most common side effects of opioid usage are constipation (which has a very high incidence) and nausea. These 2 side effects can be difficult to manage and frequently tolerance to them does not develop; this is especially true for constipation. They may be severe enough to require opioid discontinuation, and contribute to under-dosing and inadequate analgesia. Several clinical trials are underway to identify adjunct therapies that may mitigate these side effects. Switching opioids and/or routes of administration may also provide benefits for patients. Proper patient screening, education, and preemptive treatment of potential side effects may aid in maximizing effectiveness while reducing the severity of side effects and adverse events. Opioids can be considered broad spectrum analgesic agents, affecting a wide number of organ systems and influencing a large number of body functions. Key words: Opioids, morphine, methadone, fentsnyl, oxycodone, hydrocodone, xymorphone, codeine, adverse events, narcotics, side effects, constipation, sedation, hearing loss, tolerance, addiction, hyperalgesia

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Fossmark, Reidar, Tom C. Martinsen und Helge L. Waldum. „Adverse Effects of Proton Pump Inhibitors—Evidence and Plausibility“. International Journal of Molecular Sciences 20, Nr. 20 (21.10.2019): 5203. http://dx.doi.org/10.3390/ijms20205203.

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Proton pump inhibitors (PPIs) have been increasingly used over the last decades and there are concerns about overuse and the numerous reported side-effects. It is uncertain whether associations between PPI use and potential side effects are causal. However, important evidence from experimental and mechanistic studies that could support a causal relationship may have been underestimated by epidemiologists and meta-analysists. In the current manuscript we review the combined epidemiological and mechanistic evidence of the adverse effects of PPI use.

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Khanday, Suheena, Mohd Afsahul Kalam und Shameem Ahmad Rather. „ADVERSE EFFECT OF UNANI PHARMACOPOEIAL FORMULATION HABB-E-KARANJAWA“. Indian Journal of Unani Medicine 15, Nr. 01 (2022): 73–75. http://dx.doi.org/10.53390/ijum.2022.15113.

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Pharmacovigilance (PV), which is also known as drug safety. It is the pharmacological science relating to the detection, assessment, understanding and prevention of adverse effects, particularly long term, and short term side effects of medicines [1]. The key role of this field of medicine is to ensure the safe reception of drugs, examining the adverse side effects reported by patients. The compound causing side effects in the drug need to be identified and the remedy to counteract the side effect should be explored. This study was carried out at Regional Research Institute of Medicine (RRIUM), Srinagar, wherein a total of 10 patients suffering from general body ache, common cold and fever etc were analysed for the adverse side effects caused after prescribing the pharmacopoeial drug Habb-e-Karanjawa. It was observed that almost all patients suffered from gastritis after the consumption of the drug. After a thorough analysis of the ingredients of the drug it was concluded that the corrosive effect of compound copper sulphate or TutiyaSabz present in Habb-e-Karanjawa can be the main reason of causing gastrointestinal problems in patients.

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Kaiser, L. H. W. M., und M. P. J. Schols. „Dystonie reactions and hallucinations: a rare adverse-effect?“ Acta Neuropsychiatrica 4, Nr. 1 (März 1992): 12–16. http://dx.doi.org/10.1017/s0924270800034955.

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SummaryDystonie reactions and hallucinations: a rare adverse-effect? One of the intriguing side-effects of neuroleptics is the acute dystonie reaction like oculogyric crises. It is seldom mentioned that the dystonie reaction may be combined with hallucinations. This combination of acute dystonia with hallucinations may be explained by overstimulation of dopamine-receptors in the striatal neurons. Awareness of these hallucinations as a complication of neuroleptics is essential to prevent that neuroleptic dose will be increased; instead it must be lowered. Prevention of the dystonia is critical. These side effects may be suppressed with anti-parkinsonian drugs. Information to the patient in due time may prevent anxiety about the side effects.

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Nanoti, Girish, Shantanu Shembalkar und Prafulla Shembalkar. „Use of Paediatric Epilepsy Side Effects Questionnaire (PESQ) for Early Detection of Adverse Effects of Anti-Epileptic Drugs in Children with Epilepsy“. Indian Journal of Trauma and Emergency Pediatrics 8, Nr. 2 (2016): 85–94. http://dx.doi.org/10.21088/ijtep.2348.9987.8216.8.

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