Thematische Bibliographien / Calretinin

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Auswahl der wissenschaftlichen Literatur zum Thema „Calretinin“

Autor: Grafiati
Veröffentlicht am 4. Juni 2021
Zuletzt aktualisiert am 20. Februar 2023

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Zeitschriftenartikel zum Thema "Calretinin"

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Kang, Kwon Woo, Rudra Pangeni, JinWoo Park, Jaekwang Lee und Eunyoung Yi. „Selective Loss of Calretinin-Poor Cochlear Afferent Nerve Fibers in Streptozotocin-Induced Hyperglycemic Mice“. Journal of Nanoscience and Nanotechnology 20, Nr. 9 (01.09.2020): 5515–19. http://dx.doi.org/10.1166/jnn.2020.17654.

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Hearing loss is one of the major complications of diabetes mellitus and significantly lowers the quality of life of diabetic patients. In studies using diabetic animal models hearing loss have been frequently associated with damages to cochlear afferent fibers. Recent studies suggested that cochlear afferent neurons are composed of heterogeneous populations and a subgroup of neurons equipped with low level of calretinin might be more vulnerable to various noxious stimuli such as noise and neurotoxins. Here, we tested if cochlear afferent neurons deficient in the Ca2+-buffering protein calretinin are more vulnerable to hyperglycemic insults. Streptozotocin-induced (50 mg/kg, i.p.) hyperglycemic mice (>250 mg/dl) were tested. The expression patterns of calretinin in peripheral processes and the cell bodies of cochlear afferent nerve fibers were examined using immunohistochemistry and confocal microscopy. The proportion of calretinin-poor cochlear afferent fibers was much lower in hyperglycemic mice compared to the normoglycemic control group. (30.0 vs. 55.5% in the peripheral process; 15.7 vs. 24.4 % in spiral ganglion neuron). The results suggest that calretinin-poor cochlear nerve fibers may be selectively lost after the hyperglycemic insults. The finding also supports a calretinin’s neuroprotective role against diabetic neuropathy in cochlear afferent neurons.
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Portugal, Raquel, und Esther Oliva. „Calretinin“. Advances in Anatomic Pathology 16, Nr. 2 (März 2009): 118–24. http://dx.doi.org/10.1097/pap.0b013e31819923ce.

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3

Barberis, Massimo C. P., Maurizio Faleri, Silvio Veronese, Chiara Casadio und Giuseppe Viale. „Calretinin“. Acta Cytologica 41, Nr. 6 (1997): 1757–61. http://dx.doi.org/10.1159/000333181.

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Dei Tos, Angelo P., und Claudio Doglionit. „Calretinin“. Advances in Anatomic Pathology 5, Nr. 1 (Januar 1998): 61. http://dx.doi.org/10.1097/00125480-199801000-00052.

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Zupanc, Cita, Alenka Franko, Danijela Štrbac, Metoda Dodič Fikfak, Viljem Kovač, Vita Dolžan und Katja Goričar. „Serum Calretinin as a Biomarker in Malignant Mesothelioma“. Journal of Clinical Medicine 10, Nr. 21 (22.10.2021): 4875. http://dx.doi.org/10.3390/jcm10214875.

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The early diagnosis of malignant mesothelioma (MM) could improve the prognosis of MM patients. To confirm an MM diagnosis, an immunohistochemical analysis of several tumor tissue markers, including calretinin, is currently required. Our aim is to evaluate serum calretinin as a potential biomarker in asbestos-related diseases, especially in MM. Our study includes 549 subjects: 164 MM patients, 117 subjects with asbestosis, 195 subjects with pleural plaques and 73 occupationally asbestos-exposed subjects without asbestos-related diseases. The serum calretinin concentration was determined with a commercially available enzyme immunoassay. Data on the soluble mesothelin-related peptides (SMRP) concentration are available from previous studies. MM patients had a significantly higher calretinin concentration than subjects without disease, subjects with pleural plaques or subjects with asbestosis (all p < 0.001). The histological type was significantly associated with serum calretinin: patients with sarcomatoid MM had lower calretinin than patients with the epithelioid type (p = 0.001). In a ROC curve analysis, the area under the curve for calretinin concentration predicting MM was 0.826 (95% CI = 0.782–0.869; p < 0.001). At the cutoff value of 0.32 ng/mL, sensitivity was 0.683, while specificity was 0.886. The combination of calretinin and SMRP had the highest predictive value. Calretinin is a useful biomarker that can distinguish MM from other asbestos-related diseases and could, therefore, contribute to an earlier non-invasive diagnosis of MM.
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Kuźnicki, J., T. L. Wang, B. M. Martin, L. Winsky und D. M. Jacobowitz. „Localization of Ca2+-dependent conformational changes of calretinin by limited tryptic proteolysis“. Biochemical Journal 308, Nr. 2 (01.06.1995): 607–12. http://dx.doi.org/10.1042/bj3080607.

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Calretinin is an EF-hand Ca(2+)-binding protein expressed predominantly in some neurons. We have found that the tryptic digestion pattern of rat recombinant calretinin depends on Ca2+ concentration as determined by SDS/PAGE, amino-acid-sequence analysis and electrospray-ionization MS. Ca(2+)-saturated calretinin was cleaved between amino acids 60 and 61 to yield two fragments, which accumulated during cleavage. Small amounts of the larger fragment (amino acid residues 61-271) were further cleaved from the C-terminal end. Ca(2+)-free calretinin was also cleaved between residues 60 and 61; however, under the latter conditions the fragment 61-271 was further cleaved from the N-terminal end. Native rat calretinin was cleaved by trypsin in a similar Ca(2+)-dependent fashion. All identified fragments of recombinant calretinin bound 45Ca2+ on nitrocellulose filters, although to a different extent. The 61-271 fragment was released by EGTA from an octyl-agarose column in a manner similar to intact calretinin, while fragment 61-233 was not eluted by EGTA. These observations show that there are trypsin cleavage sites in calretinin that are available regardless of Ca2+ binding, other sites that are completely protected against trypsin on Ca(2+)-binding and sites which become partially available on Ca(2+)-binding. Together these data show that calretinin changes its conformation on Ca2+ binding and identify the regions which are exposed in apo and Ca(2+)-bound form.
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Pasteels, Brigitte, John Rogers, François Blachier und Roland Pochet. „Calbindin and calretinin localization in retina from different species“. Visual Neuroscience 5, Nr. 1 (Juli 1990): 1–16. http://dx.doi.org/10.1017/s0952523800000031.

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AbstractCalbindin-D28K and calretinin are homologous calcium-binding proteins localized in many neurons of the central nervous system. We have compared polyclonal antibodies against calbindin and calretinin and have shown by western blots using purified calbindin and calretinin from rat that (1) anti-calretinin does not recognize calbindin and (2) anti-calbindin presents some cross-reactivity with calretinin.In this report, we have compared by immunohistochemistry the localization of both calcium-binding proteins in the retina of monkey, pig, sheep, rat, cat, pigeon, and salamander. These results are compared with previous data for chick. There are many differences between species and not within species, but some aspects of the distribution are conserved. All species, except rat and monkey, have some cones which contain calbindin only. Most species also have some bipolar cells containing calbindin only. Calretinin is rarely seen in photoreċeptors or bipolar cells. All species have horizontal cells which contain calretinin or calbindin or both. All species have amacrine cells and ganglion cells containing one or other protein.In the cat ganglion cell layer, the calretinin antisera define a new, asymmetric, type of cell.
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Arjmandzadeh, Ehsan, und Fariba Binesh. „Determination of Relative Frequency of Calretinin Expression in Patients with Breast Cancer in Yazd, Iran“. Chinese Journal of Medical Research 3, Nr. 2 (25.06.2020): 37–40. http://dx.doi.org/10.37515/cjmr.091x.3202.

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Introduction: Breast cancer is known as the most common type of cancer among women in the world. Several methods have been proposed to predict the behavior of breast carcinoma. Recently calretinin has been found to be a reliable factor in predicting tumor survival rate in breast cancer. The aim of this study was to evaluate the relative frequency of calretinin expression in patients with breast cancer in Yazd,Iran. Material and methods: In this cross-sectional retrospective study, the clinicopathologic features and the outcome of patients with breast cancer from 2017 to 2018 were reviewed at Shahid Sadoughi Hospital, Yazd, Iran. The influence of potential prognostic parameters in the overall survival was investigated by log-rank test and Cox regression analysis. Results: Among 100 cases with breast carcinoma, 14.5% were positive for calretinin. The distribution of the rate of positivity of IHC markers including ER, PR, P53, Ki67 and Her2 was 62.9%, 57.1%, 46.2%, 80.5% and 22.1%, respectively. The most common grade and stage were grade2 and stage3 respectively. There was no significant difference in the status of IHC markers (including ER, PR, Her2 and Ki67) in terms of calretinin. 66.7% of the patients with calretinin positive results were P53 positive. The results of the mean tumor size distribution in the two groups of positive and negative calretinin showed a significant difference (P-value = 0.05). A lower age at the time of diagnosis was found in patients with calretinin positive results (P-value = 0.119). The mean survival rate in calretinin positive group was 6.71 years and 6.62 years in calretinin negative patients which was not statistically significant. Conclusion: The results of this study indicated an association between calretinin expression and other IHC markers (although not statistically significant) in predicting poor prognosis in breast cancer patients. In addition, we found a statistically significant association among calretinin with smaller tumor size and lower age at the time of diagnosis in patients with breast cancer.
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GÁBRIEL, ROBERT, BÉLA VÖLGYI und EDIT POLLÁK. „Most calretinin-containing amacrine cells in the rabbit retina co-localize glycine“. Visual Neuroscience 16, Nr. 6 (November 1999): 983–90. http://dx.doi.org/10.1017/s095252389916601x.

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Calretinin-containing retinal amacrine cells are heterogeneous with regard to their neurochemical properties. In the rabbit retina, about 90% of them contain glycine, as evidenced in the present study by double-label immunocytochemistry. In a previous report, we showed that a small population of amacrine cells contains both γ-aminobutyric acid and calretinin. In this study, we further identified this cell population by means of known secondary markers. However, none of the markers we tested (choline acetyltransferase, serotonin accumulation, NADPH-diaphorase, vasoactive intestinal polypeptide) co-localized with calretinin. A small population (1%) of the cells in the ganglion cell layer contains both calretinin and glycine. Since calretinin-positive cells in the ganglion cell layer have been identified as ganglion cells based on soma size and presence of calretinin-positive axons in the optic nerve fiber layer, this population may represent a class of ganglion cell which contains glycine. Our results, together with those of other studies, suggest that calretinin is not a general marker of any of the well-known amacrine cell types in the mammalian retina. Rather, calretinin, just as other calcium-binding proteins, is distributed in a species-specific manner. At the same time it appears that, as shown for horizontal cells, one or more of the major buffer-type calcium-binding proteins of the EF-hand family is present in most of the retinal amacrine cells.
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Venugopal, Suryagayathri, Cicy P. J., Deepa S. und Sankar Sundaram. „Calretinin expression in molecular subtypes of invasive carcinoma breast“. International Journal of Research in Medical Sciences 8, Nr. 4 (26.03.2020): 1498. http://dx.doi.org/10.18203/2320-6012.ijrms20201349.

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Background: Breast cancer is a leading cause of cancer death in women worldwide. Breast carcinoma is currently managed by assessing clinicopathological features. Elucidation of molecular mechanisms of pathogenesis of breast carcinoma may lead to the development of new targeted therapies, particularly in triple negative cancers. Literature shows a few studies on the expression of calretinin in breast carcinoma particularly in basal like type and its prognostic significance. In this study, authors are trying to assess the expression of a new marker calretinin in different molecular subtypes of invasive carcinoma breast.Methods: This study was done in 107 cases of invasive carcinoma breast specimens received in Department of Pathology, Government Medical college, Kottayam from December 2017 to May 2019.Results: Among the molecular subtypes, Basal like tumours showed 68.4% of cases with high level and 31.6% of cases with low level calretinin expression which is comparable with the study by Farrag et al. All the other molecular subgroups showed predominantly low level of calretinin expression.Conclusions: Different molecular subtypes of invasive carcinoma breast showed varied calretinin expression. High level calretinin expression was significantly associated with grade 3 (p value = 0.002), ER negativity (p = 0.004), PR negativity (p = 0.018) and Basal like molecular subtype (p : <0.001). This suggests that calretinin might play a role in pathogenesis of basal like breast carcinomas.
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Dissertationen zum Thema "Calretinin"

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Ellis, Jonathan Henry. „Development of hammerhead ribozymes against calretinin mRNA for use in transgenic mice“. Thesis, University of Cambridge, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259589.

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Terra, Simone Antunes [UNESP]. „Displasia neuronal intestinal: análise de critérios morfológicos e comparação de métodos diagnósticos“. Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/135881.

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Introdução: A Displasia Neuronal Intestinal, tipo B (DNI-B) é uma doença neuromuscular gastrointestinal caracterizada por alterações complexas do sistema nervoso entérico. Seu diagnóstico depende da análise histopatológica de biópsias do reto, com mudanças dos critérios diagnósticos ao longo dos anos, o que dificulta a prática diagnóstica. O Consenso de Frankfurt, 1990, estabeleceu critérios histológicos qualitativos para diagnóstico de DNI-B, como hiperganglionose e hiperplasia do plexo nervoso submucoso. Meier-Ruge et al. 2004, 2006, definiu o diagnóstico de maneira quantitativa: mais de 20% de gânglios nervosos gigantes na submucosa, com mais de 8 neurônios cada, em 25 gânglios examinados, e em crianças maiores de 1 ano. Objetivos: Analisar as características morfológicas do sistema nervoso entérico em pacientes com DNI-B segundo os critérios do Consenso de Frankfurt de 1990, e testar a aplicabilidade dos critérios numéricos propostos por Meier-Ruge et al 2004. Pacientes e Métodos: Foram analisadas retrospectivamente peças cirúrgicas de cólon distal de 29 pacientes, com idade de 0 a 16 anos, com diagnóstico de DNI-B, em cortes histológicos processados para histologia convencional pela hematoxilina e eosina (H&E) e para imuno-histoquímica da calretinina. Resultados: Apenas 1 paciente contemplou estes critérios numéricos. Houve imunopositividade para calretinina nos neurônios, porém a contagem de neurônios foi menor em relação ao H&E (p=0,002). Não houve diferenças significativas entre os grupos etários de crianças menores e maiores de 1 ano em relação à hiperganglionose (p=0,789), número de neurônios (p=0,359), gânglios com sinais de imaturidade (p=0,664) e neurônios hipogênicos (p>0,999). Conclusões: Os critérios numéricos recomendados em cortes de 15µm, corados por painel histoquímico específico, apresentam aplicabilidade limitada quando transpostos à análise histopatológica convencional. Houve concordância pobre nos critérios analisados entre a H&E e a calretinina. Em relação à idade, nosso estudo mostrou que crianças maiores de 1 ano podem apresentar os mesmos aspectos histológicos de imaturidade neuronal que crianças menores de 1 ano, questionando a necessidade de um critério de idade para o diagnóstico da DNI-B.
Introduction: Intestinal Neuronal Dysplasia type B (INDB) is a gastrointestinal neuromuscular disease characterized by complex changes in the enteric nervous system. The diagnosis depends on the histopathological analysis of rectal biopsies and the diagnostic criteria have changed over the years, making it difficult to diagnostic practice. The Frankfurt Consensus, 1990, established qualitative criteria for the histological diagnosis of INDB, such as gigant ganglia and hyperplasia of submucosal nerves. Meier-Ruge et al. 2004, 2006, defined quantitative criteria: over 20% of giant ganglia, with more than 8 nerve cells each, on 25 ganglia examined, and in children older than one year. Objectives: Analyze the morphological characteristics of the enteric nervous system in patients with INDB according to the Frankfurt Consensus Criteria 1990 and test the applicability of the numerical criteria proposed by Meier-Ruge et al. 2004. Patients and Methods: Surgical specimens of distal colon from 29 patients, aged 0-16 years old, diagnosed with INDB, in histological sections processed for conventional histology by hematoxylin and eosin (H&E) and for immunohistochemistry of calretinin, were retrospectively analyzed. Results: Only one patient met these numerical criteria. There was immunostaining for calretinin in neurons but the neurons count was lower in relation to H&E (p=0.002). There were no significant differences between the age groups of children younger and older than 1 year old in relation to hyperganglionosis (p=0.789), number of neurons (p=0.359), ganglion with immaturity (p=0.664) and hypogenic neurons (p>0.999). Conclusions: The numerical criteria recommended for 15μm cut, stained with specific histochemical panel, have limited applicability when transferred to conventional histopathology. There was poor agreement on the criteria analyzed between H&E and calretinin. Regarding the age, our study showed that children older one year old may present the same histological features of neuronal immaturity as children younger one year old, challenging the need for an age criterion for the diagnosis of INDB.
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Čabraja, Mario. „Stereologie Calretinin-immunopositiver Neurone des Ganglion vestibulare (Scarpae) in cerebellären und vestibulären Mäusemutanten“. [S.l.] : [s.n.], 2004. http://www.diss.fu-berlin.de/2004/139/index.html.

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4

El-Tarhouni, Amal Ibrahium. „Studies on the mechanosensory innervation of muscle using organotypic culture, reinnervation and immunohistochemistry“. Thesis, Durham University, 1996. http://etheses.dur.ac.uk/5266/.

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This thesis studies sensory innervation in mammals using an organotypic co-culture of spinal cord-dorsal root ganglion and skeletal muscle of embryonic rat, the histological changes of reinnervated muscle spindles after nerve section and the localisation of the calcium-binding protein calretinin in cat mechanoreceptor organs. The immediate importance of this project concerns the better understanding of how the normal process of development differs from reinnervation following nerve lesion or section. A range of classical and well defined materials and methods as been used in the work described. The thesis Is divided into Ove chapters: Chapter 1 reviews aspects of the mechanosensory organs which have been studied experimentally in relation to their sensory innervation, including proprioceptive muscle spindle development, reinnervation, and finally, the presence of the calcium-binding protein, calretinin in the mechanoreceptor organs. This provides an introduction and background to the work. Chapter 2 describes the organotypic organisation of spinal-cord, dorsal-root ganglia and skeletal muscle co-culture in vitro. Results show that slices of the spinal-cord, dorsal- root ganglia survive well under experimental conditions and can live for several weeks with feeding every 1-3 days. Sensory neurons can develop and grow in a medium without any additional promoting factor. The presence of structurally identifiable synapses indicates that other neurons are also maintained in culture and have functional connections. In the organotypic culture new muscle fibres can form either from the original explant or from the additional explant. In chapter 3 I describe two abnormal endings present in spindles of the tenuissimus of the cat that had been reinnervated following section of the nerve more than one year previously. The reconstruction of the endings of these two spindles supports the hypothesis of modulation of the primary-ending response by the mechanical properties of the intrafusal muscle fibres, rather than by intrinsic properties of the la afferent itself. They further indicate that, in the absence of a la afferent, intrafusal-fibre differentiation can be maintained by a group II afferent. Chapter 4 concerns the localisation of the calcium-binding protein calretinin, which was studied immunohistochemically in the abductor digiti quinti medius muscle of the cat hind limb. The calretinin immunoreactivity was found in some intrafusal fibres, the primary endings and the cqjsule of the muscle spindles and the sensory terminals of tendon organs and Paciniform corpuscles. The present findings contradict a recent hypothesis that calretinin is associated with rapid adaptation, but suggest that calretinin has a specific function in muscle proprioceptors. Finally, Chapter 5 outlines the conclusions of this study and gives some suggestions for continuation of the work in the future.
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Sänger, Kathrin Ernestine [Verfasser], und Jens [Akademischer Betreuer] Waschke. „Calretinin-Expression in Nervenendigungen der äußeren Augenmuskeln beim Menschen / Kathrin Ernestine Sänger ; Betreuer: Jens Waschke“. München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2018. http://d-nb.info/1179075838/34.

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Serafini, Suellen. „Utilização da biópsia de mucosa e submucosa retal para o diagnóstico da Moléstia de Hirschsprung“. Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/5/5141/tde-27102017-091421/.

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Introdução: A moléstia de Hirschsprung (MH) se caracteriza pela ausência de neurônios intramurais em segmentos variáveis do intestino grosso, levando a suboclusão intestinal. Na forma mais frequente o reto-sigmoide está comprometido. A biopsia retal é o método histológico de escolha no diagnóstico da MH. O método da hematoxilina e eosina (HE) é classicamente utilizado na prática histopatológica. Nessa técnica, um fragmento de parede total do reto é processado através de parafinização, para posteriormente ser seccionado e corado por HE. Esta coloração evidencia células neurais em intestinos normais e troncos nervosos hipertrofiados nos casos de MH. É uma técnica muito simples, ainda hoje muito utilizada no diagnóstico da doença, necessitando de fragmentos grandes de reto para um maior acerto no diagnóstico. Este detalhe torna o diagnóstico do recém-nascido mais difícil. Outro método de coloração utilizado no diagnóstico da MH é o método histoquímico de pesquisa de atividade de Acetilcolinesterase (AChE). Nesta técnica é necessário apenas um pequeno fragmento de mucosa e submucosa que será congelado e depois processado. A pesquisa de AChE, nos casos de MH mostrará a presença desta enzima em quantidade aumentada, corando troncos e ou fibrilas de cor acastanhado. Este método já vem sendo utilizado pelo Instituto da Criança - HCFMUSP há mais de 30 anos e possui um acerto diagnóstico superior a 90%. Porém, por ser uma técnica mais elaborada, pouquíssimos centros no Brasil a utilizam no diagnóstico da MH. Um outro método mais recente, e que também pode ser realizado em fragmentos menores, é a marcação imunohistoquímica da calretinina, que permite a visualização dos neurônios do plexo submucoso e das fibrilas finas na região da lâmina própria em não doentes. Esta técnica também apresenta maior complexidade e, portanto, não é utilizada. A possibilidade de realizar o diagnóstico da MH através da coloração HE em fragmentos menores poderia ser uma alternativa para os serviços que não dispõe de técnicas mais especificas. Objetivos: Avaliar a concordância dos resultados obtidos pelo método de coloração HE e da calretinina com a pesquisa de atividade de AChE em fragmentos de mucosa e submucosa no diagnóstico da Moléstia de Hirschsprung. Métodos: Para este trabalho foram selecionados 50 casos arquivados em nosso laboratório. O material encontrava-se emblocado em parafina. Foram feitos 60 níveis de cada fragmento para o HE e mais 3 níveis para a calretinina. Essas lâminas foram analisadas em microscópio, fotografadas e classificadas como positivas para MH quando não foram encontradas células neurais e houve a presença de troncos nervosos, e em negativas nos casos de visualização dos neurônios. Foi realizado estudo cego por dois pesquisadores. Os resultados da leitura das lâminas foram comparados com o da AChE. Resultados: Dos 50 casos avaliados pela técnica do HE, apenas 5 discordaram do diagnóstico realizado pela AChE, com um valor de Kappa de 0,800 e acurácia 90%. Na comparação entre a calretinina e a AChE 8 casos discordaram, com um valor de Kappa de 0,676 e acurácia de 84%. Conclusões: A concordância obtida entre os métodos da AChE e HE foi satisfatória. Tornando possível a utilização do método do HE em 60 níveis de fragmento de mucosa e submucosa como alternativa para o diagnóstico da MH. A técnica imunohistoquímica da Calretinina não apresentou a concordância esperada com a pesquisa de atividade de AChE em nosso estudo
Introduction: Hirschsprung disease (HD) is characterized by the absence of intramural neurons in variable segments of the large intestine, leading to intestinal subocclusion. In the most frequent form the rectum-sigmoid is compromised. Rectal biopsy is the histological method of choice in the diagnosis of HD. The hematoxylin and eosin (HE) method is classically used in histopathological practice. In this technique, a full-thickness rectum wall fragment is processed through paraffinization, to be later sectioned and stained by HE. This staining shows neural cells in normal intestines and hypertrophied nerve trunks in cases of HD. It is a very simple technique, still used today in the diagnosis of the disease, requiring large fragments of the rectum for a better diagnosis. This detail makes the diagnosis of the newborn more difficult. The staining histochemical methods more used are the research of acetylcholinesterase activity (AChE) and staining of calretinin. However, these techniques are not available in all centers and the possibility of diagnosing HD through HE staining in smaller fragments could be valuable alternative for services that do not have more specific techniques. Objectives: To evaluate the concordance of the results obtained by the HE staining and the calretinin method with the investigation of AChE activity in fragments of mucosa and submucosa in the diagnosis of Hirschsprung\'s disease. Methods: For this study, 50 cases from our laboratory were selected. The material was embedded in paraffin. Sixty levels of each fragment were made for HE and other 3 levels for calretinin. These slides were analyzed under microscope, photographed and classified as positive for HD when no nerve cells were found and there were nerve trunks present, and in negative in cases of visualization of the neurons. A blind study was carried out by two researchers. The results of reading the slides were compared with that of AChE. Results: Of the 50 cases evaluated by the HE technique, only 5 disagreed with the diagnosis performed by AChE, with a Kappa value of 0.800 and accuracy of 90%. In the comparison between calretinin and AChE, 8 cases disagreed, with a Kappa value of 0.676 and an accuracy of 84%. Conclusions: The concordance of results from AChE and HE methods was satisfactory, allowing the possibility of the use of the HE method in fragments of mucosa and submucosa as valid alternative for the diagnosis of HD. The immunohistochemical technique of Calretinin did not show a good agreement with the AChE activity in our study
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Hinterberger, Marc Lorenz. „D2-40 and calretinin : a tissue microarray analysis of 341 malignant mesotheliomas with emphasis on sarcomatoid differentiation /“. [S.l.] : [s.n.], 2009. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000281124.

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Alp, Murat. „A kinetic model of calcium binding to calretinin : experimental measurements and predicted effects on calcium signaling at neuronal synapses /“. view abstract or download file of text, 2005. http://wwwlib.umi.com/cr/uoregon/fullcit?p3190505.

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Thesis (Ph. D.)--University of Oregon, 2005.
Typescript. Includes vita and abstract. Includes bibliographical references (leaves 250 - 269). Also available for download via the World Wide Web; free to University of Oregon users.
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Silva, Joanilson Guimar?es. „Caracteriza??o de subpopula??es de interneur?nios imunorreativos para prote?nas ligantes de c?lcio no c?rtex pr?-frontal do Sagui (Callithrix jacchus): distribui??o e morfologia“. Universidade Federal do Rio Grande do Norte, 2011. http://repositorio.ufrn.br:8080/jspui/handle/123456789/17223.

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Made available in DSpace on 2014-12-17T15:36:38Z (GMT). No. of bitstreams: 1 JoanilsonGS_TESE.pdf: 3996700 bytes, checksum: 8b3084030c1c254db2c08a440881ea9a (MD5) Previous issue date: 2011-05-02
Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico
Cortical interneurons are characterized by their distinct morphological, physiological and biochemical properties, acting as modulators of the excitatory activity by pyramidal neurons, for example. Various studies have revealed differences in both distribution and density of this cell group throughout distinct cortical areas in several species. A particular class of interneuron closely related to cortical modulation is revealed by the immunohistochemistry for calcium binding proteins calbindin (CB), calretinina (CR) and parvalbumin (PV). Despite the growing amount of studies focusing on calcium binding proteins, the prefrontal cortex of primates remains relatively little explored, particularly in what concerns a better understanding of the organization of the inhibitory circuitry across its subdivisions. In the present study we characterized the morphology and distribution of neurons rich in calcium-binding proteins in the medial, orbital and dorsolateral areas of the prefrontal cortex of the marmoset (Callithrix jacchus). Using both morphometric and stereological techniques, we found that CR-reactive neurons (mainly double bouquet and bipolar cells) have a more complex dendritic arborization than CB-reactive (bitufted and basket cells) and PV-reactive neurons (chandelier cells). The neuronal densities of CR- and CB-reactive cells are higher in the supragranular layers (II/III) whilst PV-reactive neurons, conversely, are more concentrated in the infragranular layers (V/VI). CR-reactive neurons were the predominant group in the three regions evaluated, being most prevalent in dorsomedial region. Our findings point out to fundamental differences in the inhibitory circuitry of the different areas of the prefrontal cortex in marmoset
Os interneur?nios do c?rtex cerebral s?o caracterizados por suas diferentes propriedades morfol?gicas, fisiol?gicas e bioqu?micas, atuando como moduladores da atividade excitat?ria cortical dos neur?nios piramidais, por exemplo. V?rios estudos revelaram diferen?as na distribui??o e densidade deste grupo celular ao longo de diferentes ?reas corticais em diversas esp?cies. Uma classe particular de interneur?nios intimamente relacionada ? modula??o cortical ? revelada pela imunohistoqu?mica para as prote?nas ligantes de c?lcio calbindina (CB), calretinina (CR) e parvalbumina (PV). Em que pese a quantidade crescente de estudos focando nas prote?nas ligantes de c?lcio, o c?rtex pr?frontal de primatas ainda permanece relativamente pouco explorado, especialmente no que se refere a um melhor entendimento da organiza??o do circuito inibit?rio ao longo de suas subdivis?es. No presente estudo caracterizamos a morfologia e a distribui??o desse grupo neuronal nas regi?es medial, orbital e dorso-lateral do c?rtex pr?-frontal do sagui (Callithrix jacchus). Utilizando par?metros morfom?tricos e t?cnicas estereol?gicas, evidenciamos que os neur?nios reativos a CR (especialmente c?lulas em duplo-buqu? e bipolares) possuem arboriza??o dendr?tica mais complexa quando comparados aos neur?nios reativos a CB (neur?nios de tufos duplos e c?lulas em cesto) e PV (c?lulas em candelabro). A densidade dos neur?nios reativos a CB e CR ? mais elevada nas camadas supragranulares (II/III), enquanto os neur?nios reativos a PV se concentram predominantemente nas camadas infragranulares (V/VI). Os neur?nios reativos a CR foram o grupo predominante nas tr?s regi?es avaliadas, sendo mais prevalente na regi?o dorsolateral. Nossos achados apontam para diferen?as cruciais no circuito inibit?rio ao longo das diferentes ?reas do c?rtex pr?-frontal do sagui
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Roebel, John L. „Developmental Expression of Calcium-Binding Proteins in the AVCN and MNTB of Normal Hearing and Congenitally Deaf Mice“. Wright State University / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=wright1150313169.

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Bücher zum Thema "Calretinin"

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Zecevic, Nada, Zsófia Maglóczky und Filip Barinka, Hrsg. At The Top of the Interneuronal Pyramid – Calretinin Expressing Cortical Interneurons. Frontiers Media SA, 2016. http://dx.doi.org/10.3389/978-2-88919-708-8.

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Buchteile zum Thema "Calretinin"

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Rogers, John H. „Calretinin“. In Novel Calcium-Binding Proteins, 251–76. Berlin, Heidelberg: Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-76150-8_15.

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Rogers, John, Masood Khan und Jon Ellis. „Calretinin and Other CaBPs in the Nervous System“. In Advances in Experimental Medicine and Biology, 195–203. Boston, MA: Springer US, 1990. http://dx.doi.org/10.1007/978-1-4684-5754-4_32.

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Résibois, A., F. Blachier, J. H. Rogers, D. E. M. Lawson und R. Pochet. „Comparison Between Rat Brain Calbindin- and Calretinin-Immuno-reactivities“. In Advances in Experimental Medicine and Biology, 211–14. Boston, MA: Springer US, 1990. http://dx.doi.org/10.1007/978-1-4684-5754-4_34.

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Pochet, R., F. Blachier, W. Malaisse, M. Parmentier, B. Pasteels, V. Pohl, A. Résibois, J. Rogers und A. Roman. „Calbindin-D28 in Mammalian Brain, Retina, and Endocrine Pancreas: Immunohistochemical Comparison with Calretinin“. In Calcium Protein Signaling, 435–43. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4684-5679-0_46.

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Parmentier, Marc. „Structure of the Human cDNAs and Genes Coding for Calbindin D28K and Calretinin“. In Advances in Experimental Medicine and Biology, 27–34. Boston, MA: Springer US, 1990. http://dx.doi.org/10.1007/978-1-4684-5754-4_4.

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Schwaller, B. „Emerging Functions of the “Ca2+ Buffers” Parvalbumin, Calbindin D-28k and Calretinin in the Brain“. In Handbook of Neurochemistry and Molecular Neurobiology, 197–221. Boston, MA: Springer US, 2007. http://dx.doi.org/10.1007/978-0-387-30379-6_5.

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Winsky, Lois, und David M. Jacobowitz. „Purification, Identification and Regional Localization of a Brain-Specific Calretinin-Like Calcium Binding Protein (Protein 10)“. In Novel Calcium-Binding Proteins, 277–300. Berlin, Heidelberg: Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-76150-8_16.

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Mak, Tak W., Josef Penninger, John Roder, Janet Rossant und Mary Saunders. „Calretinin“. In The Gene Knockout FactsBook, 107. Elsevier, 1998. http://dx.doi.org/10.1016/b978-012466044-1/50063-6.

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„Calretinin“. In Calcium Signalling in Cancer. CRC Press, 2000. http://dx.doi.org/10.1201/noe0849309823.ch9.

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„Calretinin“. In Encyclopedia of Cancer, 602. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-16483-5_6743.

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Konferenzberichte zum Thema "Calretinin"

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Shadrina, Maria, und Petr Maslukov. „CALBINDIN-AND CALRETININ-IMMUNOREACTIVE METASOMATIC NEURONS RUT’S IN ONTOGENESIS“. In XV International interdisciplinary congress "Neuroscience for Medicine and Psychology". LLC MAKS Press, 2019. http://dx.doi.org/10.29003/m627.sudak.ns2019-15/464-465.

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Ishiba, Tohiyuki, Tomoyuki Aruga, Miyako Nara, Sakiko Yabe, Chiaki Saita, Mai Onishi, Naoko Iwamoto et al. „Abstract 5449: Calretinin can be the specific marker for phyllodes tumor“. In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-5449.

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Kuhlmann, J. D., T. Link, S. Passek, K. Frank, Y. Vassileva, M. Kramer und P. Wimberger. „Serum Calretinin als unabhängiger Prädiktor für Platinresistenz und Prognose beim Ovarialkarzinom“. In Kongressabstracts zur Tagung 2020 der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe (DGGG). © 2020. Thieme. All rights reserved., 2020. http://dx.doi.org/10.1055/s-0040-1718156.

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HACKNEY, C. M., S. MAHENDRASINGAM und R. FETTIPLACE. „IMMUNOCYTOCHEMICAL INVESTIGATIONS OF THE DISTRIBUTION OF CALBINDIN AND CALRETININ IN THE TURTLE COCHLEA“. In Proceedings of the International Symposium. WORLD SCIENTIFIC, 2003. http://dx.doi.org/10.1142/9789812704931_0006.

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Passek, S., T. Link, K. Frank, YD Vassileva, M. Kramer, JD Kuhlmann und P. Wimberger. „Serum calretinin as an independent predictor for platinum resistance and prognosis in ovarian cancer“. In Kongressabstracts zur 14. Jahrestagung der Mitteldeutschen Gesellschaft für Frauenheilkunde und Geburtshilfe e.V. (MGFG). Georg Thieme Verlag KG, 2021. http://dx.doi.org/10.1055/s-0041-1730793.

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Wimberger, P., T. Link, S. Passek, Y. Vassileva, M. Kramer und JD Kuhlmann. „EP1025 Serum calretinin as liquid biopsy marker for identifying ovarian cancer patients with poor prognosis“. In ESGO Annual Meeting Abstracts. BMJ Publishing Group Ltd, 2019. http://dx.doi.org/10.1136/ijgc-2019-esgo.1069.

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Soeroso, Noni Novisari, Ade Indriya, Andika Pradana und Rahmat Hidayat. „Diagnostic Utility of Epithelial Membrane Antigen (EMA) and Calretinin (Cal) in Malignant Pleural Mesothelioma: A Case Report“. In The 2nd International Conference on Tropical Medicine and Infectious Disease. SCITEPRESS - Science and Technology Publications, 2019. http://dx.doi.org/10.5220/0009863402050207.

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Soni, Abhishek, Nupur Bansal, A. K. Dhull, Vivek Kaushal, Rajeev Atri und Monica Verma. „Diagnostic dilemma of mesonephric adenocarcinoma cervix“. In 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685283.

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Introduction: Mesonephric carcinoma is a rare type of epithelial tumor of the uterine cervix which derive from the remnants of the paired mesonephric (Wolff’s) ducts. The incidence of such neoplasms is difficult to determine due to rarity, previous misclassification of clear cell carcinomas and yolk sac tumours as mesonephric carcinomas and potential underreporting due to misclassification of mesonephric carcinoma as Mullerian tumours or mesonephric hyperplasia. The evidence regarding the clinical course, prognosis and optimal treatment is limited. Materials and Methods: Searches were performed on MEDLINE, EMBASE and Google Scholarly articles. All the relevant articles were included in the study. Only approximate 40 cases have been reported till now. Discussion: Mesonephric adenocarcinoma cervix has different morphologies like ductal, tubular, solid, retiform, sex-cord like pattern, clear cell and serous papillary structures. IHC assessment is helpful in differentiating it from Mullerian counterpart, as it is negative for CEA, CK20, p16, PAX2, ER/PR and vimentin and positive for CD10, calretinin, CK7, CAM5.2 and EMA. It has no relation with HPV infection. Unlike squamous epithelial carcinoma, it is rarely presenting with the abnormal cervical smear result, has more advanced age at presentation and its incidence does not appear to decline with age. The diagnosis has been supported by endometrial curettings, directed/cone cervical biopsies and hysterectomy specimens. The majority of patients are diagnosed at stage IB with mean DFS of 48.6 months. Recurrence rate is 23%, with a mean interval of 40 months. Hysterectomy is the primary treatment. Advanced stage disease of adenocarcinoma seemed to respond to radiotherapy, but for the MMMTs the combination of chemotherapy with radiotherapy appears to be preferable. Conclusion: Rarity of the neoplasm, varied morphology, mix presentation and very low number of cases leads to difficulty in correct diagnosis in a small biopsy specimen. IHC helpful in differentiating it from other lesions.
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Khurana, Anil, Paramjeet Kaur, Ashok K. Chauhan, Yashpal Verma und Nupur Bansal. „Extra ovarian adult granulosa cell tumor of omentum: A report of a rare entity“. In 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685372.

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Aims: Extra ovarian granulosa cell tumor (GCT) is extremely rare tumor, assumed to arise from the ectopic gonadal tissue along the embryonal route of the genital ridge. A case of extra ovarian granulosa cell tumor of omentum in a 69 year old female presented here. Materials and Methods: A 69 years old postmenopausal, hypertensive female presented with complaints of pain in right lumber and iliac region of one month duration. Pain was off and on and intermittent. The patient had a history of hysterectomy 12 years ago for fibroid uterus. Results: Ultrasound examination of abdomen showed a hypoechoic lesion of size 78.1 mm x 57.3 mm in right iliac fossa with mild thickening of surrounding omentum. Another hypoechoic lesion of size 36.7 mm x 22.9 mm was seen in retroperitoneal region in supero-medial aspect of right kidney. CECT abdomen showed heterogeneously enhanced nodular lesion of size 6.6 x 6.8 cm in right lumbar region, mild thickening of surrounded omentum also seen however there was no evidence of infiltration to bowel loop seen. Uterus was not visualized. PET CT whole body revealed mildly metabolically active enlarged nodes in the bilateral level ib an ii, metabolically active large lobulated heterogeneously enhancing soft tissue density lesion in right lumbar region with non enhancing areas of necrosis. The lesion is closely abutting the anterior abdominal wall musculature antero laterally and small bowel loop medially surrounding mesenty shows increased vascularity and haziness. Colonoscopy findings were normal. Trucut biopsy of mass right lumbar region was positive for malignancy likely Round cell Sarcoma. A provisional diagnosis of retroperitoneal sarcoma of right lumbar region was made. She underwent exploratory laparotomy with excision of tumor. As per Operative findings there was approximately 8 x 7 cm, firm, omental mass present right to midline, arising from under surface of greater omentum. Ovaries were normal. Gross examination of omental mass showed nodular mass measuring 8 x 5 x 6 cm. External surface was multinodular and cut surface was grey brown to grey yellow with solid cystic areas and areas of necrosis. Microscopic examination of specimen showed Extraovarian Adult granulosa cell tumor/metastasis from occult granulose cell tumor. On IHC Vimentin, CK, SMA, Inhibin were positive, Ki67:15%, ER/PR were also positive and are negative for calretinin, thromobomodulin. Extensive necrosis was seen. After that she underwent rexploration and total omenectomy. HPE showed fat necrosis in omentum. All investigation showed no evidence of tumor in ovaries and at any other primary site then the patient finally diagnosed as having Granulosa cell tumor involving only omentum post op stage III C. Then patient was given six courses of chemotherapy with Inj Paclitaxel and Inj Carboplatin three weekly. Now patient is on regular follow up and disease free. Conclusion: Extra ovarian adult granulosa cell tumor of omentum is rare tumor. Multimodal treatment approaches including surgery, multi-agent chemotherapy may provide a survival benefit for patients.
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Sousa, André Maroccolo de, Ana Luíza Fleury Luciano, Gabriella Silva Garcia Tagawa, Sebastião Alves Pinto und Juarez Antônio de Sousa. „Tumor raro de ovário: tumor estromal esclerosante emmulher de 69 anos“. In 45º Congresso da SGORJ XXIV Trocando Ideias. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/jbg-0368-1416-20211311095.

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Introdução: Os tumores estromais esclerosantes (TEE) representam 2 a 6% dos tumores do estroma ovárico, e mais de 80% ocorrem em mulheres jovens, na segunda ou terceira décadas de vida. São tumores raros do tipo cordão sexual estromal. Podem manifestar-se como anomalias menstruais ou desconforto abdominal, sendo manifestações hormonais raras. São benignos e unilaterais em sua maioria. Macroscopicamente, os tumores são bem delimitados e oscilam entre 3 e 17 cm de diâmetro. A secção é sólida, branco-acinzentada, com ocasionais focos amarelados, e pode conter áreas císticas ou edematosas. Em sua histopatologia, o tumor apresenta áreas mal definidas pseudolobulares densamente celulares, separadas por um estroma fibroedematoso. A atividade mitótica é baixa. Vasos dilatados de parede fina são típicos. Do ponto de vista imuno-histoquímico, há expressão de vimentina, alfa-inibina, calretinina e CD34. Relato de caso: Paciente H.T.A.F., 69 anos, sexo feminino, com antecedente de adenocarcinoma de cólon sigmoide, foi submetida ao tratamento cirúrgico da lesão há sete meses. Recentemente apresentou massa tumoral sólida no ovário esquerdo e foi submetida a ooforectomia. A hipótese de metástase de adenocarcinoma de cólon sólida em ovário foi levantada. Realizaram-se estudos anatomopatológico e imuno-histoquímico, os quais evidenciaram TEE do ovário. Conclusão: TEE são tumores benignos, geralmente unilaterais, que afetam mulheres jovens em 80% dos casos. Entretanto, no presente relato, a paciente apresentada é uma idosa de 69 anos de idade, fato bastante incomum. Além disso, o antecedente de adenocarcinoma de cólon sigmoide sugere uma possível metástase.
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