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Thematische Bibliographien / Circadian light / Zeitschriftenartikel

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Zeitschriftenartikel zum Thema „Circadian light“

Autor: Grafiati

Veröffentlicht am 25. Juni 2021

Zuletzt aktualisiert am 29. Juli 2025

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1

Rea, Mark S., Mariana G. Figueiro, Andrew Bierman, and John D. Bullough. "Circadian light." Journal of Circadian Rhythms 8 (February 13, 2010): 2. http://dx.doi.org/10.1186/1740-3391-8-2.

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Stone, J., S. Cain, and A. Phillips. "O024 Modifying light environments according to individual circadian light sensitivity." SLEEP Advances 3, Supplement_1 (2022): A9. http://dx.doi.org/10.1093/sleepadvances/zpac029.023.

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Abstract Introduction Large inter-individual differences exist in how sensitive the circadian system is to light. Circadian light sensitivity can be affected by medications, such as antidepressants, and varies as a function of age and some mood disorders. Using a computational model, we investigated how differences in an individual’s light sensitivity can be offset by changes in their light environment to maintain stable circadian timing. Methods A previously validated computational model was used to simulate sleep and circadian timing under realistic assumptions about light and sleep schedule

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Chen, Xian, Steven Kreuser, and Dinesh Hirenallur-Shanthappa. "Far-red LED light alters circadian rhythms and elicits dark-adapted ERG responses in rodents." PLOS One 20, no. 7 (2025): e0326710. https://doi.org/10.1371/journal.pone.0326710.

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Rodents are assumed to be blind to red light, thus red light is often used in the dark phase of a light/dark cycle to facilitate study procedures using nocturnal rodents. However, effects of red light in dark phase on behaviors and circadian rhythms in rodents are not yet clear. Thus, we evaluated effects of various long wavelength red light-emitting diode (LED) light on circadian rhythm and electroretinogram (ERG) in C57BL/6J mice and Wistar Han rats. Animals were implanted with telemetry devices to measure body temperature, heart rate, blood pressure, and locomotor activity for circadian rhy

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Zhao, Kankan, Bin Ma, Yan Xu, Erinne Stirling, and Jianming Xu. "Light exposure mediates circadian rhythms of rhizosphere microbial communities." ISME Journal 15, no. 9 (2021): 2655–64. http://dx.doi.org/10.1038/s41396-021-00957-3.

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AbstractMicrobial community circadian rhythms have a broad influence on host health and even though light-induced environmental fluctuations could regulate microbial communities, the contribution of light to the circadian rhythms of rhizosphere microbial communities has received little attention. To address this gap, we monitored diel changes in the microbial communities in rice (Oryza sativa L.) rhizosphere soil under light–dark and constant dark regimes, identifying microbes with circadian rhythms caused by light exposure and microbial circadian clocks, respectively. While rhizosphere microb

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Walker, William H., Jacob R. Bumgarner, James C. Walton, et al. "Light Pollution and Cancer." International Journal of Molecular Sciences 21, no. 24 (2020): 9360. http://dx.doi.org/10.3390/ijms21249360.

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For many individuals in industrialized nations, the widespread adoption of electric lighting has dramatically affected the circadian organization of physiology and behavior. Although initially assumed to be innocuous, exposure to artificial light at night (ALAN) is associated with several disorders, including increased incidence of cancer, metabolic disorders, and mood disorders. Within this review, we present a brief overview of the molecular circadian clock system and the importance of maintaining fidelity to bright days and dark nights. We describe the interrelation between core clock genes

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Yu, Yue, and Zhanming Li. "Research Progress and Effects of Light on Poultry Circadian Rhythm Regulation Based on CiteSpace." Applied Sciences 13, no. 5 (2023): 3157. http://dx.doi.org/10.3390/app13053157.

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Light is not only an important environmental regulation factor in poultry growth and development, but it is also a key factor affecting circadian rhythm. To explore research frontiers between light and circadian rhythm, this study analyzes related literature in the field of light and circadian rhythm from the Web of Science core database and draws a knowledge graph using CiteSpace, presenting the subject distribution and research frontiers. This study also focuses on the regulation of light in the circadian rhythm of poultry, explores the effects of light on the growth and immunity of poultry,

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Moore-Ede, Martin, Anneke Heitmann, and Rainer Guttkuhn. "Circadian Potency Spectrum with Extended Exposure to Polychromatic White LED Light under Workplace Conditions." Journal of Biological Rhythms 35, no. 4 (2020): 405–15. http://dx.doi.org/10.1177/0748730420923164.

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Electric light has enabled humans to conquer the night, but light exposure at night can disrupt the circadian timing system and is associated with a diverse range of health disorders. To provide adequate lighting for visual tasks without disrupting the human circadian timing system, a precise definition of circadian spectral sensitivity is required. Prior attempts to define the circadian spectral sensitivity curve have used short (≤90-min) monochromatic light exposures in dark-adapted human subjects or in vitro dark-adapted isolated retina or melanopsin. Several lines of evidence suggest that

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Klerman, E. B., D. J. Dijk, R. E. Kronauer, and C. A. Czeisler. "Simulations of light effects on the human circadian pacemaker: implications for assessment of intrinsic period." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 270, no. 1 (1996): R271—R282. http://dx.doi.org/10.1152/ajpregu.1996.270.1.r271.

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The sensitivity of the human circadian system to light has been the subject of considerable debate. Using computer simulations of a recent quantitative model for the effects of light on the human circadian system, we investigated these effects of light during different experimental protocols. The results of the simulations indicate that the nonuniform distribution over the circadian cycle of exposure to ordinary room light seen in classical free-run studies, in which subjects select their exposure to light and darkness, can result in an observed period of approximately 25 h, even when the intr

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Wang, Yifan, Leo W. Beukeboom, Bregje Wertheim, and Roelof A. Hut. "Transcriptomic Analysis of Light-Induced Genes in Nasonia vitripennis: Possible Implications for Circadian Light Entrainment Pathways." Biology 12, no. 9 (2023): 1215. http://dx.doi.org/10.3390/biology12091215.

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Circadian entrainment to the environmental day–night cycle is essential for the optimal use of environmental resources. In insects, opsin-based photoreception in the compound eye and ocelli and CRYPTOCHROME1 (CRY1) in circadian clock neurons are thought to be involved in sensing photic information, but the genetic regulation of circadian light entrainment in species without light-sensitive CRY1 remains unclear. To elucidate a possible CRY1-independent light transduction cascade, we analyzed light-induced gene expression through RNA-sequencing in Nasonia vitripennis. Entrained wasps were subjec

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Stupfel, M., V. Gourlet, A. Perramon, P. Merat, G. Putet, and L. Court. "Comparison of ultradian and circadian oscillations of carbon dioxide production by various endotherms." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 268, no. 1 (1995): R253—R265. http://dx.doi.org/10.1152/ajpregu.1995.268.1.r253.

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Carbon dioxide emission (VCO2) was computed every 20 min from continuous CO2 concentration recordings taken during 3-30 consecutive days, in strictly controlled environmental conditions, in 54 OF1 mice, 99 Japanese quail, 66 Sprague-Dawley rats, 50 Hartley guinea pigs, 7 chicks, for 7-15 days on 2 Cynomolgus monkeys, and for 24 h on 7 premature infants. This VCO2 shows circadian and ultradian oscillations that were analyzed for frequencies and amplitudes in light-dark 12-h alternation (LD 12:12), continuous light (LL), and continuous dark (DD). Circadians were not always identified or were oft

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REA, MARK S., and MARIANA G. FIGUEIRO. "WHAT IS "HEALTHY LIGHTING?"." International Journal of High Speed Electronics and Systems 20, no. 02 (2011): 321–42. http://dx.doi.org/10.1142/s0129156411006623.

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It is well-known that the light/dark cycle incident on the retina regulates the timing of the human circadian system. Disruption of a regular, 24-hour pattern of light and dark can significantly affect our health and well-being. A wide range of modern maladies, from sleep disorders to cancer, have been linked to light-induced circadian disruption. Light has been defined, however, only in terms of the human visual system, not the circadian system. Thus, the study of light-induced circadian disruption is in need of a new definition of light (and dark). Here we contrast light as a stimulus for th

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Depres-Brummer, P., F. Levi, G. Metzger, and Y. Touitou. "Light-induced suppression of the rat circadian system." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 268, no. 5 (1995): R1111—R1116. http://dx.doi.org/10.1152/ajpregu.1995.268.5.r1111.

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In a constant environment, circadian rhythms persist with slightly altered period lengths. Results of studies with continuous light exposure are less clear, because of short exposure durations and single-variable monitoring. This study sought to characterize properties of the oscillator(s) controlling the rat's circadian system by monitoring both body temperature and locomotor activity. We observed that prolonged exposure of male Sprague-Dawley rats to continuous light (LL) systematically induced complete suppression of body temperature and locomotor activity circadian rhythms and their replac

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Hu, Wenye, and Wendy Davis. "Toward a Connected System—Understanding the Contribution of Light from Different Sources on Occupants’ Circadian Rhythms." Applied Sciences 11, no. 21 (2021): 9939. http://dx.doi.org/10.3390/app11219939.

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Light that enters humans’ eyes and impacts circadian rhythms may come from various sources, including the sun, electric lighting systems, and self-luminous displays. Occupants’ activities strongly impact the light entering their eyes, which is difficult to predict and not yet well understood. This study investigated the circadian contributions of light from different sources in real building environments to better understand the variables that influence the circadian health of occupants. Spectral irradiance distributions at a position equivalent to the front of an eye of a seated occupant in v

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Lee, Jiye, Jooyoung Lee, and Seog Ju Kim. "Current and Future Perspectives on Light Therapy Using Wearable Devices." Chronobiology in Medicine 3, no. 3 (2021): 92–96. http://dx.doi.org/10.33069/cim.2021.0019.

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Circadian rhythm is the internal clock that regulates physiological functions, including the sleep-wake cycle. Advancements in technology and lifestyle have negatively impacted the circadian rhythm, resulting in numerous sleep disorders. Because light is the most important “zeigeber” for synchronizing the circadian system, light therapy is effective for circadian rhythm sleep disorders. We compared light therapy glasses with a traditional light therapy box, summarized the characteristics of various light therapy glasses, and proposed future applications of wearable sleep technologies in light

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Wen, Peijun, Fuyun Tan, Menglai Lei, Muhammad Saddique Akbar Khan, Weihua Chen, and Xiaodong Hu. "Wavelengths and irradiances modulate the circadian rhythm of Neurospora crassa." PLOS ONE 17, no. 3 (2022): e0266266. http://dx.doi.org/10.1371/journal.pone.0266266.

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The circadian rhythm affects the biological evolution and operating mechanisms of organisms. The impact of light on the circadian rhythm is a significant concern for both biology and human well-being. However, the relation between different wavelengths, irradiances, and circadian rhythm is unknown. In this study, we compared the effects of four different monochromatic light-emitting diode (LED) light and two different irradiances on the circadian rhythm of a wild-type Neurospora crassa. The results demonstrated that the circadian rhythm of Neurospora crassa can be modulated by violet (λp = 393

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Pyatin, V., N. Romanchuk, P. Romanchuk, and A. Volobuev. "Brain, Eyes, Light: Biological Electrical Magnetism of Light and Neurorehabilitation of Cognitive Impairment." Bulletin of Science and Practice 5, no. 12 (2019): 129–55. http://dx.doi.org/10.33619/2414-2948/49/14.

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Biological electrical magnetism of light and neural networks of the brain is the adaptation and optimization of external and internal lighting conditions (type, nature, duration) to improve the cognitive brain. Homo sapiens brain operates in a 24-hour biological electrical magnetic environment. Light is the strongest synchronizing signal for the circadian system, and therefore keeps most biological and psychological rhythms internally synchronized, which is important for the optimal functioning of H. sapiens brain. Circadian Sleep–Wake disorders and chronic circadian misalignment, often seen i

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Sanchez-Cano, Ana, María José Luesma-Bartolomé, Estela Solanas, and Elvira Orduna-Hospital. "Comparative Effects of Red and Blue LED Light on Melatonin Levels During Three-Hour Exposure in Healthy Adults." Life 15, no. 5 (2025): 715. https://doi.org/10.3390/life15050715.

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Circadian rhythms, essential for regulating human physiology and behavior, are influenced by light exposure, particularly at night. This study examined the impact of red (631 nm) and blue (464 nm) LED light on melatonin secretion, a key circadian marker. Twelve participants aged 19–55 years were exposed to red and blue light for three hours (9:00 p.m.–midnight), with hourly saliva samples analyzed via ELISA to track melatonin levels. Initially, melatonin levels were comparable under both light conditions. After one hour, both lights suppressed melatonin, but differences emerged after two hours

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Meiliana, Anna, Nurrani Mustika Dewi, and Andi Wijaya. "Chronodisruption and Obesity." Indonesian Biomedical Journal 7, no. 3 (2015): 117. http://dx.doi.org/10.18585/inabj.v7i3.184.

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BACKGROUND: Attempts to understand the causes of obesity and develop new therapeutic strategies have mostly focused on caloric intake and energy expenditure. Recent studies have shown that the circadian clock controls energy homeostasis by regulating circadian expression and/or activity of enzymes, hormones, and transport systems involved in metabolism. Moreover, disruption of circadian rhythms leads to obesity and metabolic disorders.CONTENT:Regularly alternating periods of light and darkness, such as normally occur with the rising and the setting of the sun, are essential for the maintenance

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Li, Min, Peiyu Wu, Jianhua Ding, Qi Yao, and Jiaqi Ju. "The Circadian Effect Versus Mesopic Vision Effect in Road Lighting Applications." Applied Sciences 10, no. 19 (2020): 6975. http://dx.doi.org/10.3390/app10196975.

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Several models on the circadian effect have been applied to indoor circadian lighting design, but applications in road lighting have not yet been clarified. Based on existing models and circadian research, we examined equivalent melanopic lux (EML), circadian light (CLA), and circadian stimulus (CS) representing the circadian effect and the S/P ratio representing the mesopic vision effect, among a dataset of light sources at photopic adaptation illuminance values of 1, 3, 10, 30, and 100 lx. The results show that the S/P ratio correlates with EML and CS (or CLA) much stronger than it correlate

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Lemmer, Björn, Thomas Brühl, Klaus Witte, Burkhard Pflug, Wilfried Köhler, and Yvan Touitou. "Effects of bright light on circadian patterns of cyclic adenosine monophosphate, melatonin and cortisol in healthy subjects." European Journal of Endocrinology 130, no. 5 (1994): 472–77. http://dx.doi.org/10.1530/eje.0.1300472.

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Lemmer B, Brühl T, Witte K, Pflug B, Köhler W, Touitou Y. Effects of bright light on circadian patterns of cyclic adenosine monophosphate, melatonin and cortisol in healthy subjects. Eur J Endocrinol 1994; 130:472–7. ISSN 0804–4643 Bright light is known as a strong zeitgeber on human circadian rhythms and influences several endocrine and neuroendocrine functions. In the present study we examined the influence of a 3-h bright light stimulus, given at different times during the day (morning or evening), on circadian patterns of cyclic adenosine monophosphate (cAMP), melatonin and cortisol. Two g

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von Gall, Charlotte. "The Effects of Light and the Circadian System on Rhythmic Brain Function." International Journal of Molecular Sciences 23, no. 5 (2022): 2778. http://dx.doi.org/10.3390/ijms23052778.

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Life on earth has evolved under the influence of regularly recurring changes in the environment, such as the 24 h light/dark cycle. Consequently, organisms have developed endogenous clocks, generating 24 h (circadian) rhythms that serve to anticipate these rhythmic changes. In addition to these circadian rhythms, which persist in constant conditions and can be entrained to environmental rhythms, light drives rhythmic behavior and brain function, especially in nocturnal laboratory rodents. In recent decades, research has made great advances in the elucidation of the molecular circadian clockwor

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Swaminathan, Krithika, Elizabeth B. Klerman, and Andrew J. K. Phillips. "Are Individual Differences in Sleep and Circadian Timing Amplified by Use of Artificial Light Sources?" Journal of Biological Rhythms 32, no. 2 (2017): 165–76. http://dx.doi.org/10.1177/0748730417699310.

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Within the human population, there is large interindividual variability in the timing of sleep and circadian rhythms. This variability has been attributed to individual differences in sleep physiology, circadian physiology, and/or light exposure. Recent experimental evidence suggests that the latter is necessary to evoke large interindividual differences in sleep and circadian timing. We used a validated model of human sleep and circadian physiology to test the hypothesis that intrinsic differences in sleep and circadian timing are amplified by self-selected use of artificial light sources. We

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Beaulé, Christian, and Hai-Ying M. Cheng. "The Acetyltransferase CLOCK Is Dispensable for Circadian Aftereffects in Mice." Journal of Biological Rhythms 26, no. 6 (2011): 561–64. http://dx.doi.org/10.1177/0748730411416329.

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Recent demonstration of the histone acetyltransferase activity of the Clock gene greatly expanded the regulatory role of circadian clocks in gene transcription. Clock and its partner Bmal1 are responsible for the generation of circadian oscillations that are synchronized (entrained) to the external light cycle. Entraining light often produces long-lasting changes in the endogenous period called aftereffects. Aftereffects are light-dependent alterations in the speed of free-running rhythms that persist for several weeks upon termination of light exposure. How light causes such long-lasting chan

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Lu, Yihan, Wenye Hu, and Wendy Davis. "The Calculated Circadian Effects of Light Exposure from Commuting." Applied Sciences 11, no. 24 (2021): 11846. http://dx.doi.org/10.3390/app112411846.

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Light entrains human circadian rhythms, but increased time spent indoors and decreased daylight exposure may disrupt human circadian regulation and cause health problems. Much research is focused on improving indoor lighting conditions to minimize the adverse circadian impact of electric lights, and few studies investigate the circadian impact of daylight during the incidental time that people spend outdoors. For instance, when people commute from home to work, they are exposed to daylight. The purpose of this study is to investigate daylight’s impact on commuters’ circadian rhythms. Measureme

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Yoshii, Taishi, Christiane Hermann-Luibl, and Charlotte Helfrich-Förster. "Circadian light-input pathways inDrosophila." Communicative & Integrative Biology 9, no. 1 (2015): e1102805. http://dx.doi.org/10.1080/19420889.2015.1102805.

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Metz, Henry S. "Light and the circadian clock." Journal of American Association for Pediatric Ophthalmology and Strabismus 7, no. 4 (2003): 229–30. http://dx.doi.org/10.1016/s1091-8531(03)00119-8.

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Heussen, Raphaela, and David Whitmore. "The Importance of Stochastic Effects for Explaining Entrainment in the Zebrafish Circadian Clock." Computational and Mathematical Methods in Medicine 2015 (2015): 1–9. http://dx.doi.org/10.1155/2015/254979.

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The circadian clock plays a pivotal role in modulating physiological processes and has been implicated, either directly or indirectly, in a range of pathological states including cancer. Here we investigate how the circadian clock is entrained by external cues such as light. Working with zebrafish cell lines and combining light pulse experiments with simulation efforts focused on the role of synchronization effects, we find that even very modest doses of light exposure are sufficient to trigger some entrainment, whereby a higher light intensity or duration correlates with strength of the circa

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Alzate-Correa, Diego, Sydney Aten, Moray J. Campbell, Kari R. Hoyt, and Karl Obrietan. "Light-induced changes in the suprachiasmatic nucleus transcriptome regulated by the ERK/MAPK pathway." PLOS ONE 16, no. 6 (2021): e0249430. http://dx.doi.org/10.1371/journal.pone.0249430.

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The mammalian master circadian pacemaker within the suprachiasmatic nucleus (SCN) maintains tight entrainment to the 24 hr light/dark cycle via a sophisticated clock-gated rhythm in the responsiveness of the oscillator to light. A central event in this light entrainment process appears to be the rapid induction of gene expression via the ERK/MAPK pathway. Here, we used RNA array-based profiling in combination with pharmacological disruption methods to examine the contribution of ERK/MAPK signaling to light-evoked gene expression. Transient photic stimulation during the circadian night, but not

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Chen, Yaobing, and Wingfong He. "The Effect of Artificial Light Pollution on Circadian Rhythm." Theoretical and Natural Science 110, no. 1 (2025): 170–76. https://doi.org/10.54254/2753-8818/2025.au23380.

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Circadian rhythms are imperative biological processes that allow organisms, including animals and plants, to synchronize with Earths day-night cycle and to control numerous physiological mechanisms inside them. In mammals, the suprachiasmatic nucleus (SCN) in the hypothalamus acts as a central clock, while the peripheral clock, which is outside of the central clock, regulates the specific local functions. Within the circadian clock, the key genes like BMAL1, CLOCK, PER, and CRY coordinate with each other to form a feedback loop. The CCA1, LHY, and TOC1 genes can also form a feedback loop in pl

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Stack, Nora, David Barker, Mary Carskadon, and Cecilia Diniz Behn. "A Model-Based Approach to Optimizing Ultradian Forced Desynchrony Protocols for Human Circadian Research." Journal of Biological Rhythms 32, no. 5 (2017): 485–98. http://dx.doi.org/10.1177/0748730417730488.

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The human circadian system regulates internal 24-h rhythmicity and plays an important role in many aspects of human health and behavior. To investigate properties of the human circadian pacemaker such as intrinsic period and light sensitivity, experimental researchers have developed forced desynchrony (FD) protocols in which manipulations of the light-dark (LD) cycle are used to desynchronize the intrinsic circadian rhythm from the rest-activity cycle. FD protocols have typically been based on exposure to long LD cycles, but recently, ultradian FD protocols with short LD cycles have been propo

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Kjaer, Katrine Heinsvig, and Carl-Otto Ottosen. "Growth of Chrysanthemum in Response to Supplemental Light Provided by Irregular Light Breaks during the Night." Journal of the American Society for Horticultural Science 136, no. 1 (2011): 3–9. http://dx.doi.org/10.21273/jashs.136.1.3.

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Circadian rhythms are believed to be of great importance to plant growth and performance under fluctuating climate conditions. However, it is unclear how plants with a functioning circadian clock will respond to irregular light environments that disturb circadian-regulated parameters related to growth. Chrysanthemum (Chrysanthemum morifolium ‘Coral Charm’) was exposed to supplemental light provided as irregular light breaks during the night, achieved by controlling the light based on forecasted solar irradiance and electricity prices. Growth, in terms of carbon gain, was linearly correlated to

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Eo, Yun Jae, Seohyeon Kim, Keyong Nam Lee, et al. "Fabrication of Circadian Light Meter with Non-Periodic Optical Filters to Evaluate the Non-Visual Effects of Light on Humans." Applied Sciences 11, no. 18 (2021): 8283. http://dx.doi.org/10.3390/app11188283.

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Given that light is known to function as a zeitgeber, having the greatest influence on the human circadian rhythm, it is necessary to assess the effects of light on humans with the goal of maintaining the circadian rhythm. Herein, we fabricated a simple circadian light meter that directly measures the non-visual effects of light using optical filters that mimic the non-visual action spectrum. The fabricated light meter was calibrated and verified through the values obtained from a conventional illuminance spectrophotometer. Furthermore, during 24 h of everyday life, 11 participants wore hats e

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Meléndez-Fernández, O. Hecmarie, Jennifer A. Liu, and Randy J. Nelson. "Circadian Rhythms Disrupted by Light at Night and Mistimed Food Intake Alter Hormonal Rhythms and Metabolism." International Journal of Molecular Sciences 24, no. 4 (2023): 3392. http://dx.doi.org/10.3390/ijms24043392.

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Availability of artificial light and light-emitting devices have altered human temporal life, allowing 24-hour healthcare, commerce and production, and expanding social life around the clock. However, physiology and behavior that evolved in the context of 24 h solar days are frequently perturbed by exposure to artificial light at night. This is particularly salient in the context of circadian rhythms, the result of endogenous biological clocks with a rhythm of ~24 h. Circadian rhythms govern the temporal features of physiology and behavior, and are set to precisely 24 h primarily by exposure t

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Fu, Juan. "How Light Affects Circadian Rhythm and Mood Regulation." Transactions on Materials, Biotechnology and Life Sciences 3 (March 24, 2024): 298–302. http://dx.doi.org/10.62051/6rd07d81.

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Light is full of the world and illuminates our lives, and scientists believe that light must play a crucial role in affecting humans either positively or negatively including circadian functions and emotion-related behaviors. Through experiments, researchers have revealed the fact that light can affect humans significantly and the principles behind phenomena of light influencing humans both physically and mentally. This essay focuses on how light works in humans’ circadian rhythm and mood regulation, and how exactly nocturnal light exposure induces depression-like behaviors. Many research resu

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Stone, Julia E., Elise M. McGlashan, Nina Quin, et al. "The Role of Light Sensitivity and Intrinsic Circadian Period in Predicting Individual Circadian Timing." Journal of Biological Rhythms 35, no. 6 (2020): 628–40. http://dx.doi.org/10.1177/0748730420962598.

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There is large interindividual variability in circadian timing, which is underestimated by mathematical models of the circadian clock. Interindividual differences in timing have traditionally been modeled by changing the intrinsic circadian period, but recent findings reveal an additional potential source of variability: large interindividual differences in light sensitivity. Using an established model of the human circadian clock with real-world light recordings, we investigated whether changes in light sensitivity parameters or intrinsic circadian period could capture variability in circadia

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Arble, Deanna M., Jenna Holland, Nickki Ottaway, et al. "The Melanocortin-4 Receptor Integrates Circadian Light Cues and Metabolism." Endocrinology 156, no. 5 (2015): 1685–91. http://dx.doi.org/10.1210/en.2014-1937.

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The melanocortin system directs diverse physiological functions from coat color to body weight homoeostasis. A commonality among melanocortin-mediated processes is that many animals modulate similar processes on a circannual basis in response to longer, summer days, suggesting an underlying link between circadian biology and the melanocortin system. Despite key neuroanatomical substrates shared by both circadian and melanocortin-signaling pathways, little is known about the relationship between the two. Here we identify a link between circadian disruption and the control of glucose homeostasis

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Hannay, Kevin M., Victoria Booth, and Daniel B. Forger. "Macroscopic Models for Human Circadian Rhythms." Journal of Biological Rhythms 34, no. 6 (2019): 658–71. http://dx.doi.org/10.1177/0748730419878298.

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Mathematical models have a long and influential history in the study of human circadian rhythms. Accurate predictive models for the human circadian light response have been used to study the impact of a host of light exposures on the circadian system. However, generally, these models do not account for the physiological basis of these rhythms. We illustrate a new paradigm for deriving models of the human circadian light response. Beginning from a high-dimensional model of the circadian neural network, we systematically derive low-dimensional models using an approach motivated by experimental m

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Nagare, Rohan, May Woo, Piers MacNaughton, Barbara Plitnick, Brandon Tinianov, and Mariana Figueiro. "Access to Daylight at Home Improves Circadian Alignment, Sleep, and Mental Health in Healthy Adults: A Crossover Study." International Journal of Environmental Research and Public Health 18, no. 19 (2021): 9980. http://dx.doi.org/10.3390/ijerph18199980.

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As the primary environmental cue for the body’s master biological clock, light–dark patterns are key for circadian alignment and are ultimately fundamental to multiple dimensions of health including sleep and mental health. Although daylight provides the proper qualities of light for promoting circadian alignment, our modern indoor lifestyles offer fewer opportunities for adequate daylight exposure. This field study explores how increasing circadian-effective light in residences affects circadian phase, sleep, vitality, and mental health. In this crossover study, 20 residents spent one week in

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Rumanova, Valentina S., Monika Okuliarova, and Michal Zeman. "Differential Effects of Constant Light and Dim Light at Night on the Circadian Control of Metabolism and Behavior." International Journal of Molecular Sciences 21, no. 15 (2020): 5478. http://dx.doi.org/10.3390/ijms21155478.

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The disruption of circadian rhythms by environmental conditions can induce alterations in body homeostasis, from behavior to metabolism. The light:dark cycle is the most reliable environmental agent, which entrains circadian rhythms, although its credibility has decreased because of the extensive use of artificial light at night. Light pollution can compromise performance and health, but underlying mechanisms are not fully understood. The present review assesses the consequences induced by constant light (LL) in comparison with dim light at night (dLAN) on the circadian control of metabolism a

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Domínguez-Valdés, Teresa, Cristina Bonnin-Arias, Cristina Alvarez-Peregrina, et al. "Violet Light Effects on the Circadian Rest–Activity Rhythm and the Visual System." Clocks & Sleep 6, no. 3 (2024): 433–45. http://dx.doi.org/10.3390/clockssleep6030029.

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Background: Rooms illuminated by “black light” (<400 nm wavelength) has become popular, but there is not enough scientific evidence to support its implementation. This study aims to assess the effects of violet light (392 nm) on the circadian rest–activity rhythm and the visual system through animal experimentation. Materials and results: Five groups of four mice were exposed to different white light, violet light, and dark periods, and their circadian rhythm was analyzed by measuring the circadian period using rest–activity cycles. Electroretinographic recordings and structural analysis of

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Smith, Kristina M., Gencer Sancar, Rigzin Dekhang, et al. "Transcription Factors in Light and Circadian Clock Signaling Networks Revealed by Genomewide Mapping of Direct Targets for Neurospora White Collar Complex." Eukaryotic Cell 9, no. 10 (2010): 1549–56. http://dx.doi.org/10.1128/ec.00154-10.

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ABSTRACT Light signaling pathways and circadian clocks are inextricably linked and have profound effects on behavior in most organisms. Here, we used chromatin immunoprecipitation (ChIP) sequencing to uncover direct targets of the Neurospora crassa circadian regulator White Collar Complex (WCC). The WCC is a blue-light receptor and the key transcription factor of the circadian oscillator. It controls a transcriptional network that regulates ∼20% of all genes, generating daily rhythms and responses to light. We found that in response to light, WCC binds to hundreds of genomic regions, including

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Lockley, Steven W., George C. Brainard, and Charles A. Czeisler. "High Sensitivity of the Human Circadian Melatonin Rhythm to Resetting by Short Wavelength Light." Journal of Clinical Endocrinology & Metabolism 88, no. 9 (2003): 4502–5. http://dx.doi.org/10.1210/jc.2003-030570.

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The endogenous circadian oscillator in mammals, situated in the suprachiasmatic nuclei, receives environmental photic input from specialized subsets of photoreceptive retinal ganglion cells. The human circadian pacemaker is exquisitely sensitive to ocular light exposure, even in some people who are otherwise totally blind. The magnitude of the resetting response to white light depends on the timing, intensity, duration, number and pattern of exposures. We report here that the circadian resetting response in humans, as measured by the pineal melatonin rhythm, is also wavelength dependent. Expos

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Bano-Otalora, Beatriz, Franck Martial, Court Harding, et al. "Bright daytime light enhances circadian amplitude in a diurnal mammal." Proceedings of the National Academy of Sciences 118, no. 22 (2021): e2100094118. http://dx.doi.org/10.1073/pnas.2100094118.

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Mammalian circadian rhythms are orchestrated by a master pacemaker in the hypothalamic suprachiasmatic nuclei (SCN), which receives information about the 24 h light–dark cycle from the retina. The accepted function of this light signal is to reset circadian phase in order to ensure appropriate synchronization with the celestial day. Here, we ask whether light also impacts another key property of the circadian oscillation, its amplitude. To this end, we measured circadian rhythms in behavioral activity, body temperature, and SCN electrophysiological activity in the diurnal murid rodent Rhabdomy

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Kalustova, D., V. Kornaga, A. Rybalochka, and S. Valyukh. "Space of visual and circadian parameters of RGBW lighting systems." Lighting engineering and power engineering 1, no. 57 (2020): 16–21. http://dx.doi.org/10.33042/2079-424x-2020-1-57-16-21.

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Due to the proven effect of light on human circadian rhythms, nowadays researchers and developers of lighting systems (LS) concentrate on the non-visual parameters of light and methods of ensuring a safe comfortable light environment. This requires optimisation of spectral power distribution (SPD). In this view the most promising and functional are RGBW systems due to their ability to change dynamically SPD and, hence, light parameters. In this work we explore two RGBW (red-greenblue-white) systems with different white LEDs (warm white and neutral white) and the space of visual and non-visual

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Kujur, Pratibha. "Locomotor activity rhythm of catfish Heteropneustes fossilis are prominently regulated by light-dark cues." South Asian Journal of Experimental Biology 11, no. 2 (2021): 128–35. http://dx.doi.org/10.38150/sajeb.11(2).p128-135.

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It is interesting to explore, the circadian locomotor activity rhythm of dark adapted fishes. Therefore, it is aimed to investigate the circadian locomotor activity rhythm of catfish, Heteropneustes fossilis under different light regi-mens- light-dark condition LD 12:12, constant dark condition DD, constant light LL and dark-light condition DL 12:12 in both male and female. The study was conducted sequentially under LD 12: 12 (LON 0500 and LOFF 1700) and thereafter under the DD, LL and DL each for at least 10-12 consecutive days. The locomotor activity was monitored using Stanford Chronobiolog

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Rea, MS, and MG Figueiro. "Light as a circadian stimulus for architectural lighting." Lighting Research & Technology 50, no. 4 (2016): 497–510. http://dx.doi.org/10.1177/1477153516682368.

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Consideration is being given to the adoption of a new metric characterizing light as it affects the human circadian system. Much has been learned over the past couple of decades about light as a stimulus for circadian system regulation, so it is appropriate that these discussions take place. The present paper develops an argument for adopting circadian stimulus as a metric for quantifying light in architectural spaces. The circadian stimulus metric (a) was developed from several lines of biophysical research, including those from basic retinal neurophysiology; (b) has been validated in several

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Ngarambe, Jack, Inhan Kim, and Geun Young Yun. "Influences of Spectral Power Distribution on Circadian Energy, Visual Comfort and Work Performance." Sustainability 13, no. 9 (2021): 4852. http://dx.doi.org/10.3390/su13094852.

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Spectral power distribution (SPD) is an essential element that has considerable implications on circadian energy and the perception of lit environments. The present study assessed the potential influences of SPD on energy consumption (i.e., considering circadian energy), visual comfort, work performance and mood. Two lighting conditions based on light-emitting diode (LED) and organic light-emitting diode (OLED) were used as proxies for SPDs of different spectral content: dominant peak wavelength of 455 nm (LED) and 618 nm (OLED). Using measured photometric values, the circadian light (CL), mel

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Salazar-Juárez, Alberto, Carolina Escobar, and Raúl Aguilar-Roblero. "Anterior paraventricular thalamus modulates light-induced phase shifts in circadian rhythmicity in rats." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 283, no. 4 (2002): R897—R904. http://dx.doi.org/10.1152/ajpregu.00259.2002.

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The reciprocal connections between the paraventricular thalamic nucleus (PVT) and the suprachiasmatic nuclei suggest that PVT may participate in the regulation of circadian rhythms. We studied in rats the effect of lesions of the anterior and midposterior regions of the PVT on phase shifts of drinking circadian rhythm induced by light pulses at circadian times 6, 12, and 23, as well as the phase shifts produced by electrical or glutamatergic stimulation of the anterior PVT at the same circadian times. Lesion of the anterior PVT abolishes the advances induced by light during late subjective nig

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Ohashi, Michihiro, Taisuke Eto, Toaki Takasu, Yuki Motomura, and Shigekazu Higuchi. "Relationship between Circadian Phase Delay without Morning Light and Phase Advance by Bright Light Exposure the Following Morning." Clocks & Sleep 5, no. 4 (2023): 615–26. http://dx.doi.org/10.3390/clockssleep5040041.

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Humans have a circadian rhythm for which the period varies among individuals. In the present study, we investigated the amount of natural phase delay of circadian rhythms after spending a day under dim light (Day 1 to Day 2) and the amount of phase advance due to light exposure (8000 lx, 4100 K) the following morning (Day 2 to Day 3). The relationships of the phase shifts with the circadian phase, chronotype and sleep habits were also investigated. Dim light melatonin onset (DLMO) was investigated as a circadian phase marker on each day. In the 27 individuals used for the analysis, DLMO was de

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Kronauer, Richard E., Melissa A. St. Hilaire, Shadab A. Rahman, Charles A. Czeisler, and Elizabeth B. Klerman. "An Exploration of the Temporal Dynamics of Circadian Resetting Responses to Short- and Long-Duration Light Exposures: Cross-Species Consistencies and Differences." Journal of Biological Rhythms 34, no. 5 (2019): 497–514. http://dx.doi.org/10.1177/0748730419862702.

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Light is the most effective environmental stimulus for shifting the mammalian circadian pacemaker. Numerous studies have been conducted across multiple species to delineate wavelength, intensity, duration, and timing contributions to the response of the circadian pacemaker to light. Recent studies have revealed a surprising sensitivity of the human circadian pacemaker to short pulses of light. Such responses have challenged photon counting–based theories of the temporal dynamics of the mammalian circadian system to both short- and long-duration light stimuli. Here, we collate published light e

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