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Brattan, Daniel Keith. „Aspects of hydrodynamics in AdS/CMT“. Thesis, Durham University, 2013. http://etheses.dur.ac.uk/6370/.
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Condensed matter theory is the study of systems at finite density. In this thesis we will attempt to argue that gauge-gravity dualities can give deep and meaningful insights into the behaviour of strongly coupled condensed matter systems. The first three chapters will be a review of material already available in literature. Chapter 1 will introduce holography and the AdS-CFT correspondence. Particularly, in this chapter, the technique for the extraction of diffusion constants for charge and shear stress-energy-momentum fluctuations in a field theory with a holographic dual will be demonstrated. Chapter 2 will summarise relevant literature on the relativistic fluid-gravity correspondence. In the first half of the chapter it will be shown how to calculate the transport coefficients and Navier-Stokes equations for a suitable thermal field theory. The second half of chapter 2 will then be dedicated to extracting the transport coefficients for a strongly coupled field theory dual to a Reissner-Nordstrøm AdS spacetime. In chapter 3 a scaling of the metric and gauge field found in chapter 2 will be taken such that the boundary field theory admits Galilean, as opposed to relativistic, symmetry. Consequently, the governing hydrodynamic equations will be the non-relativistic, incompressible Navier-Stokes. Chapters 4 and 5 represent novel work. In chapter 4 the transport coefficients for a particular strongly coupled thermal field theory with underlying Schrodinger symmetry will be extracted from a charged, asymptotically Schrodinger spacetime. The governing hydrodynamic equations will be compressible with non-relativistic symmetry as opposed to those found via the scaling limit of chapter 3. In chapter 5 we show how knowledge of the transport coefficients of a thermal field theory can be used as a test-bed for numerical methods to explore beyond the hydrodynamic (long wavelength and low frequency) regime. With this in mind we consider Reissner-Nordstrøm AdS4 and determine the two point correlators at arbitrary frequency and momentum. Finally in chapter 6 we summarise the work discussed in this thesis and speculate about further applications of hydrodynamic techniques to strongly coupled condensed matter theories.
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Šoulák, Petr. „Aplikace CMT Advanced v průmyslové praxi“. Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2019. http://www.nusl.cz/ntk/nusl-401050.
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In presented diploma thesis is studied problematics of welding of high strength steels. This work also describes arc welding in protective atmosphere CMT Advanced. In experimental part of this work is CMT Advanced method compared with conventional arc welding in protective atmosphere in shortcut mode used for welding of Hardox 450 and Weldox 700 E. Comparing of mechanical properties of weld material are realized via transverse tensile testing and measuring of microhardness. Macrostructure and microstructure of weld was evaluated too. In the last part of this thesis is a brief economical assessment of both studied methods.
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Halepoto, Imtiaz Ali. „Scheduling and flow control in CMT-SCTP“. Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/210189.
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Jiskra, Milan. „Porovnání CMT TWIN s ostatními MIG/MAG procesy“. Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2014. http://www.nusl.cz/ntk/nusl-231134.
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The development of welding technology is constantly going forward mainly due to the reduction of production costs and the costs of additional straightening of weldments due to the welding distortion. Therefore, the leading producers of welding machine are coming with new methods and technologies. One of the innovations is also the tandem technology CMT Twin from the company Fronius. The experiment carried out in the diploma thesis confirmed that this is a very cost effective process. The CMT Twin is from the point of view of production costs of the weld cheaper variant and bring less heat into the material compared with conventional welding. Application equipment CMT Twin requires industrial robot, so the method is predestined for the series up to mass production. The CMT Twin finds application, for example in the automotive and shipbuilding industry.
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Ma, Nicholas. „Modeling and evaluation of multi-core multithreading processor architectures in SystemC“. Thesis, Kingston, Ont. : [s.n.], 2007. http://hdl.handle.net/1974/510.
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6
Paroissien, Simon. „Simulation numérique d’un assemblage métal / composite thermoplastique par CMT pins“. Thesis, Ecole centrale de Nantes, 2016. http://www.theses.fr/2016ECDN0001/document.
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Une méthode est proposée pour la modélisation d’unassemblage multimatériaux innovant visant des applicationsdans l’allègement structurel des véhicules. Dans cetassemblage une partie composite thermoplastique, est fixée àune plaque acier texturée par la technologie CMT pins.L’interface est particulièrement complexe et non linéaire : unereprésentation fine du comportement local serait extrêmementpénalisante en temps de calcul. Dans cette optique il a étéchoisi d’orienter la méthodologie vers une modélisation la plussimple possible tout en conservant de bons résultats globaux.Pour ce faire, en s’inspirant de l’état de l’art existant sur lesmultimatériaux, une campagne expérimentale a été menée surdes éprouvettes longitudinales à double recouvrement afin decaractériser cette interface. Une fois les mécanismes locauxinvestigués, deux modèles sont proposés. Le premiernumérique basé sur la méthode des éléments finis etl’introduction d’éléments cohésifs nous permet de valider leshypothèses de modélisation tout en quantifiant la répartitiondes efforts entre les picots. Le deuxième se base sur le calcullocal d’un Volume Élémentaire Représentatif pour établiranalytiquement la loi de comportement de l’interface. Cette loiest ensuite introduite sous la forme d’un ressort non linéaire ausein d’un modèle numérique simplifié de l’éprouvette. Pourfinir ces approches sont appliquées au cas d’étude industriel etles résultats sont validés par une deuxième campagneexpérimentaleA method is proposed to simulate an innovative multimaterialassembly which has applications in structural lightweight forvehicles. In this assembly, a thermoplastic composite part isfixed on a steel plate, textured by the CMT pins technology.This is an especially complex and nonlinear interface: a finerepresentation of local behaviour would be extremely costlyfor calculation. So, it has been chosen to investigate a model assimple as possible which still demonstrates accurate globalresults.An experimental campaign on double lap shear specimen,inspired by existing state of the art on multimaterial has beenset up to characterize this interface. Once local mechanismshave been understood, two models are proposed and compared.The first is numerical and based on finite elements method andcohesive elements. It allows us to validate the modelhypotheses while describing the effort repartition between thepins. The second one is based on a Representative VolumeElement. It establishes analytically the behaviour law of theinterface. This law is then inserted inside a simplifiednumerical model of the specimen by means of a nonlinearspring. To conclude, these approaches are applied to theindustrial case of study and the result have been validated by asecond experimental campaign
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Santos, Prieslei Estefânio Dominik Goulart. „Einstein-Maxwell-dilaton theory : Black holes, wormholes, and applications to AdS/CMT /“. Universidade Estadual Paulista (UNESP), 2017. http://hdl.handle.net/11449/152323.
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
No contexto de teorias de Einstein-Maxwell-dilaton, estudamos buracos negros, buracos de minhoca e aplicações à correspondência anti-de Sitter/Teoria de Matéria Condensada. Apresentamos a solução de buracos negro dyonica para a teoria de Einstein-Maxwell-dilaton escrita completamente em termos de constantes de integração, e então investigamos como definir parâmetros físicos dependentes e independentes. Escolhendo condições de contorno apropriadas para o dilaton no infinito, construímos buracos negros sem massa e uma ponte de Einstein-Rosen que satisfaz a condição de energia nula. Construímos uma solução carregada analítica de buraco de minhoca atravessável para a teoria de Einstein-Maxwell-phantom-dilaton que é livre de singularidades e conecta dois espaços de Minkowski. Usando o teorema de Gauss-Bonnet calculamos o ângulo de deflexão de um raio de luz que passa próximo este buraco de minhoca. Apresentamos o formalismo da função entropia de Sen e o aplicamos para o cálculo analítico da entropia do buraco negro extremo de uma teoria de supergravidade com N=8 em quatro dimensões. No contexto de holografia, calculamos coeficientes de transporte na presença de campos magnéticos para teorias com um termo topológico na ação. Definimos quantidades radialmente independentes subtraindo as correntes de magnetização, e então estudamos perturbações lineares em torno do horizonte a fim de expressar as condutividades elétrica, termoelétrica e térmica em termos de somente propriedades do horizonte. Combinamos as fórmulas para as condutividades com os dados do horizonte calculados usando o formalismo de Sen, e expressamos analiticamente as condutividades à temperatura zero para várias teorias cujas soluções de buraco negro não são conhecidas analiticamente.
In the context of Einstein-Maxwell-dilaton theory, we study black holes, wormholes and applications to the anti-de Sitter/Condensed Matter Theory correspondence. We present the dyonic black hole solution to the Einstein-Maxwell-dilaton theory written fully in terms of integration constants, and then investigate how to define dependent and independent physical parameters. Choosing appropriate boundary conditions for the dilaton at infinity, we construct massless black holes and an Einstein-Rosen bridge that satisfies the null energy condition. We construct an analytical charged traversable wormhole solution to the Einstein-Maxwell-phantom-dilaton theory which is free of singularities and connects two Minkowski spacetimes. Using the Gauss-Bonnet theorem we compute the deflection angle of a light ray passing close to this wormhole. We present the Sen's entropy function method and apply it to compute analytically the entropy of the extremal black hole of a gauged N=8 supergravity theory in four dimensions. In the holographic context, we compute the transport coefficients in the presence of magnetic fields for theories with a topological term in the action. We define radially independent quantities by subtracting off the magnetization currents, and then study linear perturbations around the horizon in order to express the electric, thermoelectric and heat conductivities in terms of horizon properties only. We combine the formulae for the conductivities with the horizon data computed using Sen's entropy function method, and express analytically the conductivities at zero temperature for several theories whose the full black hole solutions are not known analytically.
2103/00140-7
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Chaudhry, Rabia Khalid. „Molecular analysis of the Xlinked CMT (CMTX3) disease locus using NGS technologies“. Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/13084.
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Charcot-Marie-Tooth disease (CMT) is a genetically and clinically heterogeneous disorder of the peripheral nervous system affecting the motor and sensory neurons. X-linked CMT (CMTX) accounts for 15-20% of all cases making it the second most commonly inherited CMT. There are 6 reported loci (CMTX1, CMTX2, CMTX3, CMTX4, CMTX5 and CMTX6). Four genes, GJB1, AIFM1, PRPS1 and PDK3 are known to cause CMTX1, CMTX4, CMTX5 and CMTX6 respectively. The pathogenic cause for CMTX2 and CMTX3 remains unknown. In this study we re-analysed the three families (CMT623, CMT193-ext and US-PED2) that reported linkage to the CMTX3 interval on chromosome Xq26.3–27.1. To identify the pathogenic cause for CMTX3 disease several applications of next generation sequencing technologies including targeted capture, whole exome sequencing and RNA-sequencing were implemented to examine both the genome and transcriptome of CMTX3 patients. Targeted capture and sequence analyses of the CMTX3 interval identified a novel unreported non-coding variant (SNV7) located in the intergenic region that segregated with the disease phenotype in the two CMTX3 families (CMT623 and CMT193-ext) that were significantly linked to the CMTX3 interval. Bioinformatics analysis suggested the variant may reside in a regulatory element and possibly disrupt the binding of transcription factors required for regulation of genes important for axonal maintenance. The genomic region surrounding SNV7 was assessed for transcription properties by a reporter assay, however results suggested the variant may not have a transcriptional role in neuronal cells. In addition to the reporter assay studies, conservation analysis of the variant showed the region is not conserved which further suggests the region harbouring the SNV7 variant may not have a functional consequence. Although further studies are required to ensure the variant does not have a functional role in causing disease, it is possible the variant may represent a non-pathogenic rare polymorphism that segregates with the disease phenotype due to linkage disequilibrium within the CMTX3 linkage interval. As an alternative method to find the pathogenic cause for CMTX3 disease the transcriptome of an affected patient was analysed by RNA-seq technologies. Preliminary validation studies of the transcripts expressed and able to be detected in fibroblasts identified low expression of the FGF13 gene in the CMTX3 patients when compared to a normal control. Recent studies have shown that FGF13 is important for the architectural development of neurons and disruptions in the protein levels can affect the polarisation of neurons. Whilst the expression of FGF13 gene requires further validation it is possible that this gene is disrupted in CMTX3 disease. One of the key and unexpected findings of this study was the identification of a reported BSCL2 mutation (p.Asn88Ser) in the original CMTX3 (US-PED2) family using whole exome sequencing. Despite not identifying a mutation in the CMTX3 interval this family will be revisited once the pathogenic cause is discovered for the two large CMTX3 families showing significant linkage to the interval. Moreover, this discovery demonstrates the power of next generation sequencing technologies as a tool to identify gene mutations for small families in the absence of statistically significant linkage data. The search for the CMTX3 gene continues, however in this current study the use of next generation sequencing technologies has been instrumental in identifying a novel candidate SNV and a gene with altered expression which may have a role in CMTX3 disease. In addition to these findings this study has highlighted that the pathogenic cause is not likely to reside in the coding region of the CMTX3 interval. Therefore, in the event SNV7 and FGF13 gene are excluded for pathogenicity, future experiments and research strategies should focus on examining the non-coding region of the interval for potential structural variations as a cause for CMTX3 disease.
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Mitchell, Julie S. M. (Julie A. ). Massachusetts Institute of Technology. „OpenSPARC : how giving away CMT chip hardware implementations creates value for Sun microsystems“. Thesis, Massachusetts Institute of Technology, 2009. http://hdl.handle.net/1721.1/47869.
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Thesis (S.M.)--Massachusetts Institute of Technology, System Design and Management Program, 2009.Includes bibliographical references (p. 79-81).
This thesis uses systems thinking and system dynamics modeling to explore how open source communities such as OpenSPARC can lead to enhancement of the performance of Sun's multithreaded systems and thereby increase its market share by increasing its share of the CMT ecosystem, and the share that CMT systems have within the overall computer server business ecosystem. This study explores Sun's motivation behind its investment in the OpenSPARC community, and explains how OpenSPARC creates value for Sun. The insight into Sun's value creation and capture strategy gained from this study can be generalized and applied to similar companies who are entering a new market where the ecosystem is not yet fully developed. The companies who benefit most from this study are ones which are strategically positioned to disclose relevant knowledge of a critical component within the ecosystem that enables its development without thereby compromising the full potential for value capture within the market. The key findings of this study include: a) Market adoption of multitcore and multithreaded servers is dependent on the rewriting of software applications with parallelization in order to boost the performance of multicore and multithreaded systems. b) The overhaul of these software applications will take the coordination and involvement of all the major players in the computer industry. c) The specific business structure of Sun allows for open sourcing the components of its systems while still gaining revenue on the sale of the system as a whole.
(cont.) d) Factors attracting open source developers to write software for a particular platform include a developer's belief that his program will be successful in the market. e) The information leakage to competitors from open sourcing Sun's multithreaded processor implementation does not diminish Sun's value capture of the market. f) The benefits that open source communities can have on market adoption of multicore and multithreaded servers, provided that the disclosure of the chip hardware implementation actually improves the technical performance and economics of the application software. This thesis will explore the reasons that Sun believes the open source community can be a catalyst for the wide-spread adoption of multithreaded processors and multithreaded software required simultaneously by all the major players in the computer industry.
by Julie Mitchell.
S.M.
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Nagathota, Hadassah Pearlyn. „Design and Implementation of CMT in Real-time : Evaluation based on scheduling mechanisms“. Thesis, Blekinge Tekniska Högskola, Institutionen för kommunikationssystem, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-10815.
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Context: Standard transport layer protocols like UDP, TCP, andSCTP use only one access technology at a time. Concurrent MultipathTransmission (CMT), has been developed for parallel use of the access technologies. The main theme of this thesis work is to implement CMT in real-time and evaluate the impact of various scheduling algorithms on its performance. Objectives: The main objectives of this thesis are to implement a de-multiplexer at the source, re-sequencer at the receiver and to investigate some of the heuristics and analyzing their impact based on some performance metrics. Methods: Thorough understanding on this topic is attained by literature review of related works. To implement and evaluate the different scheduling patterns an experimental test bed is set up. For thetransmission of data, socket programming in Python is used. Varying various parameters that are involved in the experiment, performance metrics were measured and based on them statistical analysis is carried out for proper evaluation. Results: CMT is implemented in real-time test bed and concurrency is validated. Weighted Round-Robin has better performance compared to that of Round-Robin when the size of the packet is large whereas both exhibit nearly same behavior for smaller packet sizes. Conclusions: It can be concluded that Weighted Round-Robin attains higher throughput. It can be possibly due to more load of fragmentation when large packets are transmitted on the high reliable path and hence better performance than Round-Robin. There is need for further evaluation of other metrics like delay, jitter and using other scheduling mechanisms and in other environments as well.
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Toma, Cristian Marius. „Maîtrise des interfaces hétérogènes lors d'une opération de soudo-brasage : application au couple aluminium - magnésium“. Thesis, Dijon, 2012. http://www.theses.fr/2012DIJOS012/document.
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Les travaux concernent l'étude de l’assemblage dissimilaire d’alliages d'aluminium (Al4043, Al5356) et de magnésium (RZ5, AZ31) par les procédés CMT et laser. La méthode des plans d'expériences statistiques a été mise en oeuvre afin d'analyser les effets des paramètres opératoires de soudage et la nature chimique des substrats et des fils d’apport. Les effets chimiques, thermomécaniques et énergétiques ont été étudiés dans l'objectif de contrôler et de diminuer l’épaisseur de la couche intermétallique formée entre la zone fondue et le métal de base et considérée comme critique pour la fissuration. La microstructure a été caractérisée par microscopie optique, MEB, EDS, rayons X, dureté et nano-indentation.La rupture dans la couche d’interface est liée à la formation de composés intermétalliques (Al3Mg2, Al12Mg17), d'une dureté jusqu’à 350 HV0,025, ainsi qu'à l'épaisseur de la couche et des éléments d'alliage. Le RZ5 a été assemblé avec succès avec le fil d’apport Al4043 par les deux procédés CMT et laser.Suite à l’analyse systématique des résultats, qui montre un meilleur comportement d’Al4043/RZ5 qui contient du zirconium, l'ajout de cet élément dans la zone fondue a permis de montrer une amélioration de la qualité des joints par effet sur la microstructure.Pour l’assemblage laser, une modification des conditions des vitesses de refroidissement par un pompage thermique plus rapide par l’utilisation d’un support de plaques de cuivre a induit une modification des couches d'interface et montre tout l'intérêt de maîtriser les conditions opératoires. Par ailleurs, une vibration ultrasonore des substrats a été testée pour modifier la formation des zones problématiquesThis work concern a study of the dissimilar joining of aluminium (Al4043, Al5356) and magnesium (RZ5, AZ31) by CMT and laser welding process. The method of statistical design of experiments has been implemented in order to analyse the effects of the technological welding parameters and the chemical nature of the base and filler metal. The chemical, thermo-mechanical and energetic effect were studied with the aim to control and decrease the thickness of the intermetallic layer formed between the melted zone and the base metal and considered to be critical to cracking. The microstructure was studied by optical and SEM microscopy, EDS, X-ray, hardness and nanoindentation.The fracture produced in the interface layer has been related to the intermetallic compounds (Al3Mg2 and Al12Mg17), with a hardness up to 350 HV0.025, as well of the thickness of the interface layer and to the alloying composition. The RZ5 as base metal was successfully joined with the Al4043 welding wire, in both CMT and laser process.According to the systematically analyse, who shows a better welding ability of the couples Al4043/RZ5, which contains zirconium, by the adding of this element in the molten metal the welding ability improvement was showed.For the laser joining, a modification of the cooling condition by a accelerate thermal cycle, by using a copper support for the base metal was induce a modification of the interface layer, showing the interest of mastering the technical condition. Moreover, a ultrasonically vibration of the base metal was tested in attempting to modify the formation of the problematical zones
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Almeida, Leslie Avila do Brasil. „Avaliação de tratamento homeopático com Phytolacca decandra 30CH durante a lactação de vacas com mastite subclínica“. Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/10/10134/tde-20072009-130359/.
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O elevado custo dos tratamentos tradicionais da mastite bovina, associado à redução de produção e inviabilidade de tratamento das mastites subclínicas durante a lactação, bem como a exigência cada vez mais rigorosa da ausência de resíduos de antimicrobianos por parte de instituições nacionais e internacionais, impulsiona o desenvolvimento de novas alternativas terapêuticas que visem minimizar o impacto das medidas tradicionais de tratamento. A homeopatia surge como importante alternativa, sendo aceita nacional e internacionalmente. O objetivo do trabalho foi avaliar o tratamento homeopático com Phytolacca decandra 30CH durante a lactação de vacas com mastite subclínica, utilizando parâmetros de qualidade do leite como Califórnia Mastitis Test (CMT), contagem de células somáticas (CCS) totais, porcentagens de polimorfonucleares (PMN) e de mononucleares (MN), teores de proteína, lactose, gordura, sólidos totais (ST) e extrato seco desengordurado (ESD), além da mensuração da produção leiteira. Foram selecionadas 26 vacas, CMT 2+ e 3+ sem sinais de mastite clínica, entre o terceiro e sexto mês de lactação, pluríparas e divididas em dois grupos, um com tratamentos medicamentosos mensais e outro com tratamentos quinzenais. Mensalmente foram colhidas duas amostras de leite de cada glândula mamária (teto) que apresentava mastite subclínica. Uma das amostras foi utilizada para CCS e análise dos componentes do leite, e a outra para identificação microbiológica. Nos grupos tratados, foi administrado o medicamento homeopático Phytolaca decandra 30CH diluído em água e aspergido nas mucosas oro-nasais e vaginais, enquanto que nos grupos denominados controle foi administrado placebo da mesma maneira. A pesagem da produção láctea de ambos os grupos foi realizada quinzenalmente até o final do experimento. Verificou-se então que não houve diferença significativa entre a produção láctea, CCS e a presença de microrganismos na secreção láctea das glândulas quando comparadas antes e depois do tratamento homeopático, dentro de cada grupo, bem como quando comparados os grupos entre si. As medianas de CMT e porcentagens de PMN foram compatíveis com infecções mamárias agudas, embora os animais tenham sido diagnosticados como portadores de mastites crônicas e em nenhum momento desenvolveram sinais clínicos.The high cost of traditional treatments of bovine mastitis, with the reduction of production and impracticable treatment of subclinical mastitis during lactation, as well as the requirement of an increased demand for absence of antimicrobial agents residues by national and international institutions, drives the development of new therapeutic alternatives in order to minimizing the impact of traditional treatment measures. The homeopathy appears as an important alternative, accepted domestically and internationally. The objective of this work was to evaluate homeopathic treatment with Phytolacca decandra 30CH during the lactation of cows with subclinical mastitis, using some milk quality parameters as California Mastitis Test (CMT), total somatic cell count (SCC), percentages of polymorphonuclear (PMN) and mononuclear (MN) cells, levels of protein, lactose, fat, total solids and dry defatted matter, in addition to the measurement of milk production. Twenty-six cows were selected with CMT 2 + and 3 + without any signs of clinical mastitis, between the third and sixth month of lactation, pluriparous and they were divided into two groups, with monthly or biweekly drug treatments. Monthly were collected two milk samples from each mammary gland (teat) that presented subclinical mastitis. One of the samples was used for analysis of SCC and milk components, and the other one for microbiological identification. In the treated groups, was given the homeopathic medicine Phytolaca decandra 30CH diluted in water and sprayed in the oral-nasal and vaginal mucosa, while to the control group was given placebo following the same method. The weighing of the milk production for both groups was performed fortnightly until the end of the experiment. There was no significant difference between milk production, SCC and the presence of microorganisms in milk gland secretion compared before and after homeopathic treatment, within each group as well as comparing the groups together. The medians of CMT and percentages of PMN were compatible with acute mammary infection, in spite of they have been diagnosed as carriers of chronic mastitis, and at any time no clinical signs have been developed.
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KOLI, YASHWANT. „MECHANICAL AND MICROSTRUCTURAL CHARACTERIZATION OF DISSIMILAR JOINT OBTAINED BY GMAW USING COLD METAL TRANSFER (CMT)“. Thesis, DELHI TECHNOLOGICAL UNIVERSITY, 2021. http://dspace.dtu.ac.in:8080/jspui/handle/repository/18773.
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This research work focuses on a comparative study on weld bead geometries of three
different welding techniques: Cold Metal Transfer (CMT), Metal Inert Gas Pulse Synergic
(MIG P) and MIG Manual Standard (MIG M). Bead-on-plate tests were performed using
ER4043 (AlSi5%) as a filler material on the 3.18 mm thick plates of AA6061-T6. Current
(80 A, 100 A and 120 A) and welding speed (7.5, 10.5 and 13.5 mm/sec) were used as
input process parameters while shielding gas flow rate and contact tip to workpiece
distance (CTWD) were maintained constant as 15 l/min and 10mm respectively. The weld
beads processed by all the three techniques are compared by analysing the weld bead
geometry. Microstructural characterization is carried out using optical microscopy and
Field Emission Scanning Electron Microscope (FESEM). CMT has high dilution and
penetration with low heat input. Compared to MIG P and MIG M, CMT shows a drastic
reduction in residual stresses. Multi-response mathematical model is established for
prediction of weld bead geometry in CMT, MIG P and MIG M welding of AA6061-T6
using ER4043 (AlSi5%) as a filler material. Central composite face-centered design
(CCFCD) under response surface methodology (RSM) is employed to develop the design
matrix for conducting the experiments. The developed model is employed in finding the
optimal process parameters for good weld bead aesthetics. Current (I) and welding speed
(S) are opted as input process parameters for response output such as penetration, dilution
and heat input. This model is proficient to forecast the main effects and interactive effects
of two factor of the opted welding process parameters. Results show that higher current
values with low welding speed results in deeper penetration, high amount of dilution with
higher heat input and vice versa. With lower heat input, CMT has high dilution and
penetration with respect to MIG P and MIG M welding. The optimal process parameters
are 92.518A and 7.50mm/sec for CMT, 109.418A and 10.873mm/sec for MIG P,
110.847A and 11.527mm/sec for MIG M with 61.11%, 68.80% and 72.6% desirability,
respectively. Predicted output values generated from regression model equation obtained
from welding process parameters are very close and sometimes overlaid on actual output
that obviously demonstrates the suitability of the second order regression equations. A
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good amount of penetration and dilution with low heat input is required for better joint
efficiency.
The requirements projected by many industries for stronger, lighter, more efficient
and cost-effective combined alloys in the welding of two dissimilar materials or dissimilar
thickness. The current industry trend is the coalescence of various aluminium alloys of
varying thicknesses. CMT welding process was used for joining of AA6061-T6 and
AA6082-T6 using ER4043 filler wire and inspected the effect of different process
parameters on mechanical properties of welded butt joints. Current (I), welding speed or
travel speed (TS) and gas flow rate (Q) are the input welding process parameters that are
to be optimized. Different heat input is studied w.r.t welding speed, current and gas flow
rate. Heat inputs ranging from 100+, 200+ and 300+ J/mm is achieved at constant welding
speed of 9, 7 and 5 mm/sec respectively at variable currents and flow rates. Bead geometry
variables such as penetration (P), reinforcement (R) and contact angle (CA) are
distinguished at different heat inputs. Mechanical properties such as tensile test and
microhardness for different heat input were investigated. Microstructural characterization
of base metal (BM), fusion line (FL) and weld metal (WM) is carried out. High-Resolution
X-ray Diffraction (HR-XRD) technique based on cosα method is used for residual stress
measurements at different heat inputs. Tensile fractured surfaces were examined by
FESEM and energy-dispersive X-ray spectroscopy (EDX). Butt joints of various different
process parameters were fabricated with the help of full factorial CCFCD under RSM to
optimize the tensile properties, microhardness and residual stresses. Grey relation analysis
(GRA) with Principal component analysis (PCA) is incorporated with CCFCD for finding
out the optimal process parameter by considering multi-response parameters
simultaneously. ANOVA was executed to interpret the impact of process parameters on
the mechanical properties of the weldments. Results showed that the most dominant
process parameter was found to be the welding speed. The optimal process parameter
obtained via GRA-PCA technique is I3-TS1-Q1 (I - 100 A, TS - 5 mm/sec and Q - 14
L/min having heat input 352 J/mm) which produces 226 MPa of ultimate tensile strength,
12.6 % of elongation, 68.7 HV of microhardness and -152.3 MPa of compressive residual
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stress. Desirability of optimality level obtained through CCFCD was 65.99 % and
significantly improved to 97.07 % through GRA-PCA.
Nowadays, to enhance the structural efficiency, ultrasonic vibrations are combined
with other manufacturing processes such as welding. It gives considerable advantages in
terms of improved mechanical properties, adequate surface strength, improved material
flow and uniform grain growth etc. Ultrasonic assisted cold metal transfer (U-CMT)
welding is performed to fabricate the joints and improvements in mechanical properties
and microstructural modifications are studied. Non-destructive technique (NDT) such as
radiography technique (RT) is used to test weld consistency. Results revealed improved
weld bead geometry with the aid of ultrasonic vibrations for the same welding parameters.
The tensile strength and micro-hardness are enhanced. Samples with ultrasonic vibration
experiences grain refining as compared to without vibration samples. As compared with
CMT, U-CMT joints are rich in Al-Si eutectic structure. Al-Si structure is in globular form
with reduced porosity level.
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Tedla, Sukesh Kumar. „Performance Evaluation of Concurrent Multipath Transmission : Measurements and Analysis“. Thesis, Blekinge Tekniska Högskola, Institutionen för kommunikationssystem, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-10811.
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Context: The data transmission mechanisms in a multi-homed network has gained importance in the past few years because of its potentials. Concurrent multipath transmission (CMT) technique uses the available network interfaces for transmission by pooling multiple paths together. It allows transport mechanisms to work independent of the underlying technology, which resembles the concept of Transport Virtualization (TV). As a result, in the development of Future Internet Architectures (FIA), TV plays a vital role. The leading commercial software technologies like IOS and Android have implemented such mechanisms in their devices. Multipath TCP and CMT-SCTP are the protocols under development which support this feature. The implementation and evaluation of CMT in real-time is complex because of the challenges like path binding, out-of-order packet delivery, packet-reordering and end-to-end delay. Objectives: The main objective of this thesis is to identify the possibilities of implementing CMT in real-time using multiple access technologies, and to evaluate the performance of transmission by measurements and analysis under different scenarios. Methods: To fulfill the objectives of the thesis, different methods are adopted. The development of CMT scenario is based on a spiral methodology where each spiral refers to different objectives. The sub-stages in a spiral are mainly implementation, observations, decisions and modifications. In order to implement and identify the possibilities of CMT in real-time, a deep literature study is performed beforehand. Results: The throughput of data transmission is less affected by varying the total number of TCP connections in transmission. Under different cases it is observed that the throughput has significant impact by varying number of efficient paths in transmission. Conclusion: From the experimental methodology of this work it can be observed that, CMT can be implemented in real-time using off-the-shelf components. Based on the experimentation results, it can be concluded that the throughput of transmission is affected by increasing number of paths. It can also be concluded that the total number of TCP connections during the transmission have less impact on throughput.
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Mathis, Stéphane. „Corrélations génotype/phénotype dans la maladie de Charcot-Marie-Tooth : l'exemple des mutations du gène INF2“. Thesis, Limoges, 2014. http://www.theses.fr/2014LIMO0038/document.
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La maladie de Charcot-Marie-Tooth (CMT) est une pathologie neurologique affectant le système nerveux périphérique. Bien que décrite à la fin du XIXème siècle, la découverte d’une anomalie génétique n’a été identifiée chez ces patients que dans les années 1990 (duplication du gène PMP22). Depuis, de nombreux gènes ont été incriminés, et leur nombre ne cesse d’augmenter. Ainsi, cette multitude de gènes nous incite à rechercher des corrélations phénotype-génotype qui permettent d’orienter au mieux le diagnostic et la prise en charge de ces patients. Comme nous le montrons au travers de nos travaux, il est possible de s’appuyer sur des données cliniques, biologiques, électrophysiologiques (voire radiologiques) et histo-pathologiques (biopsie de nerf) pour orienter la recherche d’anomalies génétiques. Pour illustrer ceci, nous nous sommes appuyés sur l’exemple des mutations du gène INF2, gène récemment associé à la maladie de Charcot-Marie-Tooth. Dans ce cas précis, l’atteinte rénale, le profil électrophysiologique (forme « intermédiaire » de CMT) et surtout les données histo-pathologiques (la biopsie de nerf permettant de retrouver la présence d’expansions schwanniennes caractéristiques) sont évocatrices de la présence d’une anomalie portée par ce gène. D’autres exemples de corrélations génotype-phénotype sont apportés au travers d’observationsCharcot-Marie-Tooth disease (CMT) is a neurological disorder of the peripheral nervous system. Even if it was described in the end of the nineteenth century, the first genetic abnormality (PMP22 duplication) was found only in the end of the twentieth century. Several other genes were found to be associated with this disease. This important number of potential genes leads us to find genotype-phenotype correlations in order to better and earlier diagnose these patients. As we can show it in our work, it is possible to use biological, electrophysiological (sometimes radiological) and pathological (nerve biopsy) in order to direct the genetic analysis towards the incriminated gene. To illustrate this, we have particularly study the INF2 gene, a gene recently associated with CMT. In this example, clinical (CMT phenotype and renal failure), electrophysiological (intermediate form of CMT), and pathological (supernumerary extensions of Schwann cells cytoplasm) features call to mind mutations in the INF2 gene. Other examples of genotype-phenotype correlations associated with various genes are reported in this manuscript
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Boubaker, Chokri. „Etude génétique de familles consanguines atteintes de diverses formes de la maladie de Charcot-Marie-Tooth“. Thesis, Aix-Marseille, 2013. http://www.theses.fr/2013AIXM5010.
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La maladie de Charcot-Marie-Tooth représente un groupe hétérogène de maladies tant sur le plan clinique que sur le plan génétique. A ce jour, on dénombre 60 gènes décrits dans la maladie de CMT. En Tunisie, le fort taux de consanguinité est un facteur majeur de l'apparition des maladies génétiques en particulier des formes autosomiques récessives parmi lesquelles, on trouve la maladie de Charcot-Marie-Tooth. Deux formes de CMT ont été identifiées dans cette population, il s'agit de la forme CMT4A et la forme de CMT4B2. Mes travaux de thèse ont consisté à identifier de nouveaux gènes chez des familles tunisiennes consanguines atteintes de CMT en utilisant différentes approches de criblages. J'ai poursuivi aussi des travaux de localisation réalisées chez deux familles libanaises consanguines et pour lesquelles les analyses n'ont pas permis d'identifier une région homozygote par descendance. Nous avons pu caractériser les formes CMT4H, CMT4C et CMT1A dans la population tunisienne. Nous avons identifié une nouvelle mutation dans le gène FGD4 impliquée dans la forme CMT4H. Nous avons pu caractériser la forme CMT4C par l'identification d'une nouvelle mutation dans le gène SH3TC2. En utilisant la technique d'hybridation génomique comparative sur des puces CGH , le criblage nous a permis de mettre en évidence la forme dominante CMT1A chez des patients tunisiensMy research is entitled "Molecular analysis of consanguineous families Tunisian and Lebanese with clinical signs of Charcot-Marie-Tooth disease". The objectives of the PhD research were to identify and localize the genes implicated in these clinic forms of CMT and to elucidate the functional impact of mutations and the associated physiopathology mechanisms. For this purpose several technologies were used such as Fluorescent Direct Sequencing of known genes published in CMT disease. We have identified two novel mutations in patients from consanguineous Tunisian families: the first mutation (c.514_514insG; p.Ala172Glyfs*27) was detected in FGD4 by Fluorescent direct sequencing. Skin and nerve biopsy structure of these patients were studied under a microscope. Furthermore, the expression profile of FRABIN was studied by western blot. The cellular localization of this protein is under further examinations with the use of immunofluorescent. The second mutation (c.2968delC; p.Leu990Trpfs*24) was identified using High throughput sequencing in the SH3TC2 gene, The duplication of CMT1A in patients from Tunisia was demonstrated by Array CGH technique. The identified mutations will be subjected to functional studies to determine their impact on protein and to investigate the pathophysiology of this disease. Detail data analysis is currently underway for these projects using High throughput sequencing and other methods as appropriate in both Tunisian and Lebanese families
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McCorquodale, Donald S. III. „Identification of Novel Phospholipid Related Functions of Mitofusin 2 in Cell Models of Charcot-Marie-Tooth Disease 2A“. Scholarly Repository, 2011. http://scholarlyrepository.miami.edu/oa_dissertations/580.
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The mitofusin 1 and 2 (MFN and MFN2) proteins reside in the outer mitochondrial membrane and have been shown to regulate mitochondrial network architecture by mediating tethering and fusion of mitochondria. Mitochondria normally form a tubular and branched reticular network dynamically regulated by a balance of fusion and fission events. Absence of either Mfn1 or Mfn2 results in a fragmented mitochondrial network. Züchner et al. previously described mutations in the gene mitofusin 2 (MFN2) as the cause of the major autosomal-dominant, axonal form of Charcot-Marie-Tooth neuropathy (CMT2A). CMT type 2 (CMT2) is characterized by chronic axonal degeneration of peripheral nerves leading to the loss of functional nerve fibers. Mutations in MFN2 are the most common cause of CMT2, and in Chapter 2 we report the results from a genetic screen of MFN2 in a CMT2 patient cohort. The original finding that mutations in MFN2 cause CMT2A led to investigations focused on deficiencies of mitochondrial fusion and transport, specifically in the context of long axonal processes affected in CMT. While some experimental work supports disrupted mitochondrial transport in the etiology of CMT2A, other studies on CMT2A patient fibroblasts and cell models suggest abnormal mitochondrial fusion and dynamics do not underlie the etiology of this. In the first half of Chapter 3, we present some of our initial investigations prior to de Brito and Scorrano’s report published in 2008 regarding a novel role for Mfn2 in tethering the endoplasmic reticulum (ER) to mitochondria. In Mfn2 null mouse embryonic fibroblasts (MEFs) regions of contact between mitochondria and the endoplasmic reticulum (ER) are significantly reduced. These regions of contact are thought to form specialized subdomains of the ER, called mitochondrial associated membranes (MAM). Besides observing a fragmented ER network in Mfn2 knockout (KO) mouse embryonic (MEF) cells, de Brito and Scorrano presented several lines of evidence which suggest that the underlying pathogenic mechanism in CMT2A stems from disrupted ER-mitochondria. As this observation had not been replicated in the literature, we describe our attempts to replicate these finding in the last half of Chapter 3. The MAM represents a sub-domain of the ER in close association with the mitochondrial outer membrane. The movement of phosphatidylserine (PS) from the MAM domains of the ER to mitochondria and its subsequent decarboxylation to phosphatidylethanolamine (PE) by the enzyme PS decarboxylase (Pisd) has been well characterized and is known to depend on the existence of an outer mitochondrial membrane protein. As PE has curvature inducing and fusogenic biophysical characteristics, a deficiency in PE would be an attractive mechanism contributing to the morphological and fusion defects observed in Mfn2 null cell models. We hypothesized that loss of Mfn2 would lead to specific decreases in mitochondrial and cellular levels of PE. Chapter 4 describes experiments designed to test this hypothesis. We observed significantly lower levels of PE in Mfn2 null cells, yet observe similar changes in Mfn1 null cells. Likewise, other lipid species such as ether linked PE (ePE) are decreased. To investigate how CMT2A mutations in MFN2 influence cellular phospholipid profiles, we then profiled cellular phospholipids of CMT2A patients and control lymphoblasts. We hypothesized that mutations in MFN2 would result in decreased levels of PE. In Chapter 5, we report the results of a phospholipid screen which reveal changes in ePE in CMT2A patient lymphoblasts, without the drastic decreases in PE previously observed in Mfn2 null lines. In conclusion, our data indicates an important role for both mitofusins in the mitochondrial synthesis of PE. In the context of CMT2A mutations, ePE levels are specifically reduced. Future studies may reveal how deficiencies in ePE might have important functional consequences in the pathogenesis of CMT2A.
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Baudot, Cécile. „Caractérisation fonctionnelle de FRABIN : protéine mutée dans la maladie de Charcot-Marie-Tooth de type 4H“. Thesis, Aix-Marseille 2, 2011. http://www.theses.fr/2011AIX20713.
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La maladie de Charcot-Marie-Tooth de type 4H est une neuropathie héréditaire sensitivo-motrice démyélinisante à transmission récessive. Elle est causée par à des mutations dans le gène FGD4 codant la protéine FRABIN, RhoGEF comportant cinq domaines fonctionnels : un domaine FAB de liaison à l’actine, un domaine DH à activité d’échange GDP/GTP sur les petites RhoGTPases, deux domaines PH et un domaine FYVE impliqués tous trois dans la liaison aux polyphosphoinositides. D’une part, nous avons pu identifier trois nouvelles mutations, portant à dix le nombre de mutations dans FGD4. D’autre part, des études transcriptionnelles ont permis de caractériser huit transcrits alternatifs pouvant coder pour différentes isoformes de FRABIN, dépourvues de différents domaines. Ces résultats suggèrent que FRABIN pourrait être une protéine modulaire. J’ai pu montrer que, dans les fibroblastes des patients, la protéine FRABIN était absente. Dans les lymphoblastes, nous supposons que l’isoforme FRABIN présente est dépourvue du domaine de liaison à l’actine, mais nous n’avons pas pu analyser l’effet des mutations sur la production de la protéine. Dans les fibroblastes et les lignées lymphoblastoïdes des patients, j’ai pu mettre en évidence une diminution drastique de l’activation des RhoGTPases CDC42 et RAC1. Cependant, cette diminution n’a pas pu être corrélée avec des anomalies du cytosquelette ou de la migration des fibroblastes des patients. Toutefois, ces RhoGTPases sont primordiales pour la myélinisation, il est donc fort possible que dans les cellules du système nerveux périphérique, la perte de FRABIN résultant en une diminution de plus de 50% de l’activation des RhoGTPases entraîne des défauts majeurs dans le processus de « radial sorting ». L’arrivée des souris KO conditionnelles pour fgd4 dans les cellules de Schwann ou dans les motoneurones, devrait nous permettre de valider ou d’infirmer plusieurs hypothèses qui ont été émises durant ce travail et ainsi de mieux comprendre la physiopathologie de la maladieCMT4H is an autosomal recessive demyelinating CMT due to mutations in FGD4, which encodes FRABIN. FRABIN has five functional domains: a F-actin binding domain, a RhoGEF domain with GDP/GTP exchange activity, two PH and one FYVE domains which interact with polyphosphoinositides. In this study, we identified three novel FGD4 mutations, bringing to ten the number of mutations in this gene. Moreover, I characterized eight alternative transcripts, and all of them could lead to a functional FRABIN isoform, deprived of one or more functional domains. This led us to consider FRABIN as a modular protein. In patient’s fibroblasts, I have been able to show that FRABIN is degraded. Unlike in patient’s lymphoblastoïd cells line where we were unable to characterize the mutation effect on the protein. In these cells, we proposed that FRABIN is present without the F actin binding domain. Nevertheless, in patient’s fibroblasts and lymphoblastoïde cells line, I showed a major diminution of the CDC42 and RAC1 active forms, which is not in correlation with the absence of abnormalities in cytoskeleton and migration of patient‘s fibroblasts. We suggested that, in peripheral nerve system cells, the diminution of these RhoGTPases activation is damaging for the myelination. We are waiting for two fgd4 conditional KO mice model (one in Schwann cells and one in neuron). Exploration of these models will allow us to explain the physiopathological mechanism of CMT4H
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Rabarimeriarijaona, Sitraka. „Mécanismes physiopathologiques de la forme AR-CMT2A de la maladie de Charcot-Marie-Tooth“. Thesis, Aix-Marseille, 2014. http://www.theses.fr/2014AIXM5087.
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La maladie de Charcot-Marie-Tooth (CMT) est une maladie neurologique héréditaire du système nerveux périphérique. A ce jour, près de 80 gènes sont décrits comme étant à l’origine d’une forme de CMT dont tous les modes de transmission sont connus. AR-CMT2A est due à une mutation faux-sens homozygote, c.892C>T, dans l’exon 5 du gène LMNA et conduit à la substitution d’une Arginine par une Cystéine (p.Arg298Cys) au sein d’un motif conservé du domaine central coil des Lamines de type A. L’étude présentée ici fait suite à un certain nombre d’observations ayant démontré la diminution de l’expression du gène dans les cellules de patients, et la perte d’interaction entre les Lamines A/C mutées et le facteur de transcription c-Jun. Or celui-ci participe au complexe régulateur AP-1 pour lequel le promoteur du gène LMNA possède deux éléments de fixation. L’ensemble du travail exposé dans ce manuscrit s’est donc basé sur l’hypothèse selon laquelle les Lamines de type A auraient la capacité de réguler leur propre expression et seraient capables, dans le nerf périphérique, d’établir des interactions avec des partenaires spécifiques du nerf périphériqueCharcot-Marie-Tooth (CMT) disorders constitute a complex and heterogeneous group of hereditary motor and sensory neuropathies characterized by muscle weakness and wasting, foot and hand deformities and electrophysiological changes. Genetically, CMT is characterized by a great heterogeneity, with all modes of inheritance and more than 50 genes described to date. My PhD work focuses on AR-CMT2A, a rare autosomal recessive axonal form of CMT, due to a unique homozygous missense mutation c.892C>T in LMNA exon 5, which leads to the substitution of an arginine by a cysteine (p.Arg298Cys) within a conserved motif in the central rod domain of A-type Lamins. My work aimed at providing clues toward a better understanding of the physiopathological mechanisms underlying AR-CMT2A and is based on previous results for my research team, showing a decrease in the expression of LMNA in patients’ cells, and a loss of interaction between A-type Lamins and the transcription factor c-Jun in patients’ cells. c-Jun is a member of the AP-1 complex, a well-known dimeric transcription factor, and for which interestingly, the LMNA promoter has two binding sites. All the work outlined in this manuscript is based on the hypothesis that A-type Lamins, have the capacity to regulate their own expression and therefore, are also most probably involved in interactions with partners involved in gene regulation, in particular in the Peripheral Nerve System
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Bardeau, Christian. „« À cœur vaillant rien d’impossible » : Métaphores et métonymies – Étude sémantique cognitive des occurrences du mot « cœur » en contexte“. Thesis, Umeå universitet, Institutionen för språkstudier, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-146487.
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Juškevičiūtė, Laura. „Gydymo įtaka slaptojo mastito kontrolei“. Master's thesis, Lithuanian Academic Libraries Network (LABT), 2014. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2014~D_20140305_140201-68603.
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Darbo tikslas: Išanalizuoti karvių bandos pieno kokybinę sudėtį ir patikslinti trūkinamų karvių profilaktikai taikomų medikamentų poveikį.
Darbo uždaviniai:
1. Išanalizuoti karvių bandos pieno kokybinę sudėtį.
2. Tiriamojoje karvių fermoje reagentu CMT ištirti pasirinktų tyrimams karvių tešmens ketvirčius, prieš užtrūkinant ir po apsiveršiavimo praėjus 10dienų .
3. Atlikti bakteriologinius pieno tyrimus, prieš užtrūkinant ir po apsiveršiavimo praėjus 10dienų .
4. Nustatyti preparatų gydomąjį efektyvumą.
Mokslinis - tiriamasis darbas buvo atliekamas 2010 – 2013 metais, privačiame ūkyje, Tauragės raj. Tyrimui buvo atrinktos 20 karvių, kurios buvo sugrupuotos į dvi grupes po 10 karvių. Grupėms buvo skirtas skirtingas gydymas, 1 –oji grupė gydyta preparatu „Rilexine 500“, 2 – oji grupė preparatu „OrbeSeal“. Prieš gydymą ir po gydymo buvo stebėtas SLS, pieno baltymų, riebalų, laktozės ir urėjos kiekio kitimas. Taip pat mastito sukėlėjų diagnozavimas, tešmens ketvirčių užkrėstumas.
Išanalizavus bandos pieno kokybinę sudėtį, galima teigti, kad pieno kokybiniai rodikliai ima gerėti, po sėkmingo mastito gydymo.
Prieš užtrūkinant abiejų grupių karvių teigiamai į CMT testą reagavo 55 % ketvirčių. Po veršiavimosi praėjus 10 dienų, pirmos grupės karvių į CMT teigiamai reagavo tik 10 %, o antros grupės karvių – 37,5 % ketvirčių. Pažeisti dažniau buvo galiniai ketvirčiai, lyginant su priekiniais.
Prieš užtrūkinant 1 grupės karves, pagrindinė pieno mėginių mikroflora buvo sąlyginai... [toliau žr. visą tekstą]Goal of the work: To analyze the qualitative composition of milk in the cow herd and effects of medications used for prevention of the termination of cow lactation. Tasks of the work: 1. To analyse the qualitative composition of milk in the cow herd. 2. Using the CMT reagent in the analysed cow farm, to examine the udder quarters of cows is selected for analysis, before termination of lactation and in 10 days after calving. 3. To perform bacteriological milk tests before termination of lactation and in 10 days after calving. 4. To determine the effectiveness of therapeutic preparations. The research work has been carried out in 2010–2013 in the private farm in Tauragė district. 20 cows were selected as the sample for research, and grouped into two groups of 10 cows. Groups received different treatment, the first group was treated with Rilexine 500, the second group with OrbeSeal preparation. Changes in the SCC, milk protein, fat, lactose and urea content were monitored before and after treatment along with diagnostics of mastitis pathogens and infection of the udder quarters. The analysis of the qualitative composition of the herd milk allows the state that the qualitative milk indicators start to improve after successful treatment of mastitis. Before termination of lactation, 55% quarters of both groups of cows showed positive response to the CMT test. 10 days after calving, only 10 % quarters of the first group of cows and 37.5% quarters of the second group of cows... [to full text]
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Siddell, Anna. „Unraveling The Pathogenic Molecular Mechanisms Of Morc2 Mutations Causing Charcot-Marie-Tooth Type 2Z“. Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/15910.
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Charcot-Marie-Tooth (CMT) neuropathy is a group of clinically and genetically heterogeneous diseases characterized by slow progressive length-dependent degeneration of motor and sensory peripheral nerves. A new form of axonal CMT (CMT2Z) was recently identified and is caused by mutations in the Microrchidia 2 (MORC2) gene. It is currently not known how mutations in the MORC2 gene cause axonal degeneration. The MORC2 protein is a chromatin modifier involved in the epigenetic regulation of gene transcription and DNA repair. MORC2 also regulates the activity of ATP-citrate lyase in the cytoplasm, which catalyzes the formation of acetyl-CoA. The missense mutation (c.568C>T, R190W) has been identified in seven unrelated families and is the most common mutation to date. To improve the understanding of the genetic and functional mechanisms by which MORC2 mutations lead to disease the following aims were undertaken (1) to assess the genetic mechanism of the recurrent MORC2 R190W mutation, (2) to conduct functional evaluation of the disease-associated MORC2 mutations (E174G/R190W) and (3) to establish a C. elegans model for CMT2Z. Bisulfite sequencing showed the c.568C nucleotide, which resides within a CpG dinucleotide, is prone to methylation suggesting that methylation-mediated deamination of the CpG dinucleotide may give rise to the recurrent MORC2 R190W mutation. Cell models have shown MORC2 mutations (E174G/R190W) do not affect expression or subcellular localization. ATP-citrate lyase activity was also normal in fibroblast cells from a patient with the MORC2 R190W mutation. This suggests the mechanism through which the MORC2 mutations cause disease involves impaired DNA repair and/or altered gene expression or an unknown function. C. elegans strains overexpressing human MORC2 wild type (WT) or mutant (R190W) protein specifically in the GABAergic motor neurons were also generated. Human WT and mutant MORC2 caused neuron morphological defects. Therefore, both WT and mutant MORC2 protein appears to be toxic to C. elegans GABAergic neurons. This thesis has addressed fundamental questions regarding the pathogenicity of MORC2 mutations and has provided direction for future experiments.
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INVERNIZZI, BRUNO P. „Soldagem circunferencial do aço inoxidável super duplex UNS S32750 pelo processo MIG com controle CMT®“. reponame:Repositório Institucional do IPEN, 2017. http://repositorio.ipen.br:8080/xmlui/handle/123456789/28014.
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Neste trabalho foram realizados experimentos de soldagem circunferencial em tubos de aço inoxidável super duplex UNS S32750, com diâmetros de 19,05 mm e 48,20 mm. Foram executadas soldas utilizando-se diversos parâmetros de soldagem num equipamento MIG com controle CMT® Cold Metal Transfer. Os cordões de solda foram avaliados por inspeção visual e dimensional, além dos ensaios de tração e microdureza Vickers, bem como a análise microestrutural em conjunto com análise de precipitação de fases, a qual foi realizada em acordo com a prática A da norma ASTM A923, e ensaio de corrosão conforme a prática A da norma ASTM G48 em conjunto com a norma ASTM A923. Os resultados indicaram que a soldagem do tubo com diâmetro de 19,05 mm apresentou cordão de solda com dimensões inaceitáveis conforme norma, tendo sido esta condição atribuída a utilização de um elevado diâmetro do arame para as condições (parâmetros) usadas de soldagem. A soldagem do tubo com diâmetro de 48,20 mm apresentou falta de penetração nas condições empregadas, quando soldado pelo processo CMT® convencional. No caso da utilização do CMT® combinado com arco pulsado, em condições que geraram maior aporte de calor durante a soldagem, assim obteve-se penetração total da junta e acabamento superficial adequado. Os resultados indicaram que a soldagem utilizando o processo CMT® combinado com arco pulsado, nas condições (parâmetros) empregados geraram bom acabamento superficial, aliado propriedades mecânicas compatíveis, atendendo exigências de normas, bem como uma microestrutura balanceada e alta resistência à corrosão.
Dissertação (Mestrado em Tecnologia Nuclear)
IPEN/D
Instituto de Pesquisas Energéticas e Nucleares - IPEN-CNEN/SP
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Invernizzi, Bruno Pizol. „Soldagem circunferencial do aço inoxidável super duplex UNS S32750 pelo processo MIG com controle CMT®“. Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/85/85134/tde-23052017-152804/.
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Neste trabalho foram realizados experimentos de soldagem circunferencial em tubos de aço inoxidável super duplex UNS S32750, com diâmetros de 19,05 mm e 48,20 mm. Foram executadas soldas utilizando-se diversos parâmetros de soldagem num equipamento MIG com controle CMT® Cold Metal Transfer. Os cordões de solda foram avaliados por inspeção visual e dimensional, além dos ensaios de tração e microdureza Vickers, bem como a análise microestrutural em conjunto com análise de precipitação de fases, a qual foi realizada em acordo com a prática A da norma ASTM A923, e ensaio de corrosão conforme a prática A da norma ASTM G48 em conjunto com a norma ASTM A923. Os resultados indicaram que a soldagem do tubo com diâmetro de 19,05 mm apresentou cordão de solda com dimensões inaceitáveis conforme norma, tendo sido esta condição atribuída a utilização de um elevado diâmetro do arame para as condições (parâmetros) usadas de soldagem. A soldagem do tubo com diâmetro de 48,20 mm apresentou falta de penetração nas condições empregadas, quando soldado pelo processo CMT® convencional. No caso da utilização do CMT® combinado com arco pulsado, em condições que geraram maior aporte de calor durante a soldagem, assim obteve-se penetração total da junta e acabamento superficial adequado. Os resultados indicaram que a soldagem utilizando o processo CMT® combinado com arco pulsado, nas condições (parâmetros) empregados geraram bom acabamento superficial, aliado propriedades mecânicas compatíveis, atendendo exigências de normas, bem como uma microestrutura balanceada e alta resistência à corrosão.This study carried out circumferential welding experiments in UNS S32750 Super Duplex Stainless Steel tubes using diameters of 19,05 mm and 48,20 mm. Welds were performed using various welding parameters on a MIG machine with Cold Metal Transfer® CMT control. The weld joints were evaluated by visual and dimensional inspection in addition to the Vickers microhardness and traction tests, as well as the microstructural analysis in conjunction with phase precipitation analysis, which was performed according to practice A of ASTM A923, and corrosion test in accordance with practice A of ASTM G48 in conjunction with ASTM A923. The results indicated that welds performed in pipes with a diameter of 19.05 mm showed a weld joint with unacceptable dimensions according to the standard, this condition being attributed the use of a high wire diameter for the welding conditions used. Welding performed for pipes with a diameter of 48.20 mm showed a lack of penetration under the conditions employed when welded by the conventional CMT® process. In the case of the use of CMT® combined with pulsed arc, under conditions that generated greater heat input during welding, this resulted in total penetration of the joint and adequate surface finish. The results indicated that welding using the CMT® process combined with pulsed arc, under the conditions (parameters) employed generated good surface finish, combined mechanical properties, meeting standards requirements, as well as a balanced microstructure and high resistance to corrosion.
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Pettersson, Christopher. „Differences in Animal Metaphorsbetween English and Japanese : A CMT study of English and Japanese idiomatic expressions“. Thesis, Umeå universitet, Institutionen för språkstudier, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-181617.
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Boubel, Jacques. „Etude d'une famille présentant sur cinq générations une association CMT et luxation congénitale de la hanche“. Montpellier 1, 2000. http://www.theses.fr/2000MON11138.
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Hart, Janelle Marie. „Contextualized Motivation Theory (CMT) : intellectual passion, mathematical need, social responsibility, and personal agency in learning Mathematics /“. Diss., CLICK HERE for online access, 2010. http://contentdm.lib.byu.edu/ETD/image/etd3393.pdf.
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Kotaich, Farah. „Neurofilaments in health and Charcot-Marie-Tooth Disease“. Electronic Thesis or Diss., Lyon 1, 2024. http://www.theses.fr/2024LYO10352.
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Les neurofilaments (NFs) sont le constituant le plus stable et le plus abondant des neurones matures. S'interconnectant avec les filaments d'actine et les microtubules, ils constituent le cytosquelette neuronal. Causes génétiques de la maladie de Parkinson, de la sclérose latérale amyotrophique (SLA) et des maladies de Charcot-Marie-Tooth (CMT), les NFs s’agrègent de façon anormale et précoce dans de la plupart des maladies neurodégénératives chez l'homme. Présentant une prévalence de 1/2500 personnes, les CMTs sont reconnues comme les maladies neurodégénératives les plus courantes du système nerveux périphérique et sont classées en forme démyélinisante (CMT1) et axonale (CMT2). Des mutations dans le gène NF-L, la sous-unité constituant le noyau des NFs provoque à la fois des neuropathies démyélinisantes et axonales, démontrant une communication entre les neurones et les cellules gliales du système nerveux périphérique. Puisque l’ablation génétique des NFs a démontré un effet bénéfique spectaculaire dans différents modèles murins des maladies de CMT et SLA, trouver des stratégies qui réduisent la charge des NFs chez l'homme constitue une voie thérapeutique prometteuse pour les CMTs et d'autres maladies neurodégénératives. Dans ce projet, mon objectif est d’explorer pour la première fois dans le Danio rerio (poisson zèbre), la dynamique des NFs dans les maladies CMTs, et d’examiner l'effet de leur régulation sur les neurones et les cellules myélinisantes. Mon but est de déchiffrer comment les mutations dans le réseau neuronal des NFs peuvent provoquer une forme axonale (CMT2) mais également démyélinisante (CMT1) de la maladie, et à plus long-terme de fournir des tests robustes pour une intervention thérapeutique in vivoNeurofilaments (NFs) are considered one of the most stable and abundant proteins of mature neurons. Interconnecting with the actin filaments and the microtubules, they constitute the neuronal cytoskeleton. In addition to being a primary genetic cause of Parkinson's, Amyotrophic Lateral Sclerosis (ALS), and Charcot- Marie-Tooth (CMT) diseases, NF aggregation is a pathological hallmark for most neurodegenerative diseases in humans. Presenting a prevalence of 1/2500 person, CMTs are the most common neurodegenerative disorder of the peripheral nervous system and are classified into demyelinating (CMT1) and axonal (CMT2). Mutations in the NF-L gene, the subunit constituting the core of NFs can cause both demyelinating and axonal neuropathies, hence evidencing a close interplay between neurons and glial cells in the peripheral nervous system. Since the genetic removal of NFs has shown spectacular benefits in several mouse models for ALS and CMT, finding strategies that would reduce NF burden in humans will constitute a promising therapeutic path for CMT and other neurodegenerative diseases. In this project, my objective is to explore for the first time in the Danio rerio (zebrafish) the dynamic of NFs in CMT diseases, and the effect of their regulation on the neurons and myelinating cells. I aim to explore how mutations in the neuronal NF network can cause both an axonal form (CMT2) and a demyelinating (CMT1) form of the pathology with the long-term goal of providing robust readout tests for therapeutic intervention in vivo
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Wozniak, Magdalena [Verfasser], und Peter [Akademischer Betreuer] Young. „Geschlechterspezifische Unterschiede bei Patient(inn)en mit Charcot-Marie-Tooth(CMT)-Neuropathie / Magdalena Wozniak ; Betreuer: Peter Young“. Münster : Universitäts- und Landesbibliothek Münster, 2018. http://d-nb.info/1170229174/34.
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Rocha, Aline Marubayashi. „Screening mutacional do gene HINT1 em uma amostra da população brasileira com quadro clínico de CMT recessivo“. Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/17/17140/tde-06012017-112710/.
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O grande grupo heterogêneo de neuropatias periféricas hereditárias estão entre os casos mais comuns de perda sensitiva e fraqueza muscular em crianças e adolescentes. Pelo menos 84 genes estão envolvidos com neuropatias sensitivo-motoras hereditárias (NSMH), sendo suas formas de herança mais comuns as autossômico-dominantes desmielinizante e axonal e as neuropatias ligadas ao cromossomo X, e as mais raras as autossômicorecessivas desmielinizante e axonal e as formas ainda não classificadas. O gene HINT1, possuinte de 3 exons e localizado no cromossomo 5, codifica a proteína Histidine triad nucleotide binding protein 1, uma variante transcricional (mRNA) regulatória que hidroliza substratos. Recentemente mutações em HINT1 foram também relacionadas à neuropatias axonais com neuromiotonia (ARCMT2-NM), e portanto à CMT. O objetivo deste trabalho foi realizar o screening mutacional do gene HINT1 em uma amostra da população brasileira com quadro clínico de CMT recessivo (CMT2-AR), e foram encontradas 1 mutação silenciosa já previamente descrita, 1 polimorfismo exônico e 1 polimorfismo intrônico, também já conhecidos. Concluiu-se que mutações no gene HINT1 não são portanto responsáveis pela CMT-AR nesta amostra da população brasileira.The large heterogeneous group of inherited peripheral neuropathies are among the most common causes of sensory loss and muscle weakness in children and adolescents. At least 84 genes are involved in inherited sensorymotor neuropathies (NSMH), being the demyelinating and axonal autosomaldominant and the X-linked neuropathies their most common forms of inheritance, and the demyelinating and axonal autosomal-recessive and not yet classified forms the most rare ones. The HINT1 gene, with 3 exons and located on chromosome 5, encodes the protein Histidine triad nucleotide binding protein 1, a regulatory transcriptional variant (mRNA) that hydrolyzes substrates. Recently, mutations in HINT1 were also related to axonal neuropathy with neuromyotonia (ARCMT2-NM), and therefore to CMT. The objective of this study was the mutational screening of the HINT1 gene in a sample of the Brazilian population with clinical recessive CMT (CMT2-AR), and 1 silent mutation previously described, 1 intronic polymorphism and 1 exonic polymorphism, both also known, were founded. It was then concluded that mutations in the HINT1 gene are not responsible for CMT2-AR in this particular sample of the Brazilian population.
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Penso, Graciela Carolina. „Welding of X65 Internally Clad with Precipitation Strengthened Ni-Based SUperalloy Filler Metal: Application in Pre-Salt Oil Extraction“. The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1480600980467914.
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Werheid, Friederike [Verfasser], Kristl [Akademischer Betreuer] Claeys und Ingo [Akademischer Betreuer] Kurth. „Underestimated associated features in CMT neuropathies: clinical indicators for the causative gene? / Friederike Werheid ; Kristl Claeys, Ingo Kurth“. Aachen : Universitätsbibliothek der RWTH Aachen, 2017. http://d-nb.info/1162559977/34.
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Soprunenko, Valeriia. „Optimalizace parametrů svařování na robotech pro automobilový průmysl“. Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2020. http://www.nusl.cz/ntk/nusl-417108.
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Thesis deals with individual technology of new welding processes "specifically FRONIUS TPSi". The greatest emphasis is on welding technology, especially on the differences between the individual methods. The experimental part of the thesis is focused on finding suitable parameters for welding filled welds.Everythingwith respect to required welds quality welded by robotic welding. The samples were evaluated in terms of penetration depth, amount of heat introduced and the number of defects.
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Wojciechowski, Elizabeth. „Personalised orthotic therapy using 3D printing in children with Charcot-Marie-Tooth disease“. Thesis, University of Sydney, 2020. https://hdl.handle.net/2123/23718.
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Children with Charcot-Marie-Tooth disease (CMT), are often prescribed custom-made ankle-foot orthoses (AFO) to manage walking difficulty. These externally worn assistive devices are usually handmade using a plaster cast of the patient's lower limb followed by thermoplastic vacuum forming. This traditional approach is labour-intensive and provides limited design options, resulting in AFOs which are cumbersome and associated with low acceptability, discomfort and suboptimal biomechanical function. The aim of this PhD Thesis was to develop, redesign and evaluate 3D printed AFOs compared to traditional handmade AFOs for children with CMT. A systematic literature review revealed that 3D printing AFOs has many potential benefits over traditional methods, including the development of novel designs that optimise stiffness and energy dissipation, improve gait, comfort and fit. The relationship between functional ability in 60 children with CMT and associated gait deviations using 3D gait analysis was assessed. The results showed that not all children with CMT have the typically described foot drop, push-off deficit and ‘steppage gait’ pattern. Instead, three distinct gait patterns exist at the ankle, indicating patient-specific orthotic design pathways. In 12 children with CMT, traditional handmade AFOs, replicated and iteratively redesigned 3D printed AFOs were compared to a shoe only condition using 3D gait analysis, in-shoe pedobarography and a patient satisfaction scale. Replicated 3D printed AFOs were comparable to traditional AFOs for all gait outcomes and patient satisfaction scores. Iteratively redesigned 3D printed AFOs reduced mass by, on average, 35% and improved ankle plantarflexion angle during the push-off phase of gait by up to 7°. The design, gait and acceptability of traditionally handmade AFOs can be replicated and redesigned with 3D printing in children with CMT.
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Benoit, Alexandre. „Développement du soudage MIG CMT pour la réparation de pièces aéronautiques. Application aux pièces en alliage base aluminium 6061“. Thesis, Paris 11, 2012. http://www.theses.fr/2012PA112308/document.
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Cette étude répond à une demande industrielle de réparation d’une pièce aéronautique en alliage d’aluminium 6061 à l’aide d’un procédé de soudage à l’arc. La première partie est consacrée à la comparaison des procédés Metal Inert Gas (MIG), MIG pulsé, Tungsten Inert Gas et MIG Cold Metal transfer (CMT). C’est ce dernier procédé qui a été sélectionné pour ses aptitudes particulières, comme son bon contrôle des paramètres et le faible endommagement produit dans le métal de base. Puis, deux métaux d’apport ont été testés – les alliages 5356 et 6061 – avec deux stratégies de réparation : le soudage et le rechargement. Les résultats d’essais mécaniques ont démontré que le rechargement avec l’aluminium 5356 est l’option la plus adaptée pour cette application. Les essais sur pièce réelle ont prouvé la pertinence de cette approche.La zone affectée thermiquement générée, dans l’alliage 6061, par les procédés de soudage à l’arc a également été caractérisée. Il a été mis en évidence une variation de la microstructure associée aux changements de propriétés mécaniques de cette zone. Enfin, les essais exploratoires de soudage homogène à l’arc, c’est-à-dire, avec le métal d’apport en 6061, ont prouvé qu’il était possible, dans certaines conditions, de souder sans générer de fissuration, bien que, cet aluminium soit réputé comme étant insoudable de cette manièreThis study responds to an industrial demand of repair using an arc welding process. It concerns an aeronautical piece made in 6061 aluminium alloy. The first part of the study is devoted to the comparison of processes Metal Inert Gas (MIG), pulsed MIG, Tungsten Inert Gas and MIG Cold Metal Transfer (CMT). It is the latter process that was selected for its special abilities, such as its good control of parameters and the low damaging produced in the base metal. Then, two filler alloys were tested – 5356 and 6061 aluminium alloys– with two repairing strategies : welding and building up. The results of mechanical tests showed that building up with aluminum 5356 is most suitable option for this application. The trials on the real piece showed the relevance of this approach.The heat affected zone generated by the arc welding process in the 6061 base metal was also characterized. It was shown a varaition of microstructure associated with the change of mechanical properties in this zone. Finally, exploratory trials of homogeneous arc welding, i.e., with the 6061 filler alloy showed that it was possible, with certain conditions, to weld without generating weld cracking, although, this aluminium is deemed unweldable by this way
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Canizarez, Torres Herlys Hernando. „Avaliação do passe de raiz em junta de chanfro estreito na soldagem orbital pelo processo GMAW CMT e convencional“. reponame:Repositório Institucional da UnB, 2016. http://repositorio.unb.br/handle/10482/21251.
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Dissertação (mestrado)—Universidade de Brasília, Faculdade de Tecnologia, Departamento de Engenharia Mecânica, 2016.Submitted by Fernanda Percia França (fernandafranca@bce.unb.br) on 2016-07-28T14:38:03Z No. of bitstreams: 1 2016_HerlysHernandoCanizarezTorres.pdf: 62083823 bytes, checksum: ea0812a9e62c9c0300d4df9961cfd3e0 (MD5)
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Neste trabalho se apresenta uma metodologia para união de tubos pelo processo de soldagem com a deposição do passe de raiz. Na realização da soldagem de topo, externa e sem abertura de raiz, a altura da face de raiz é um fator fundamental para obter penetração total. Em alguns casos, mata-juntas (podem ser de cobre o de materiais cerâmicos) são usadas para evitar vazamentos de solda. Porém, o cobre pode ocasionar inclusões e corrosão, além de trazer muitas dificuldades no momento de instalação e gerar grandes custos em campo. Assim sendo, realizou-se uma análise do efeito da penetração utilizando-se o método de fase de nariz decrescente na soldagem de passe de raiz sem uso de cobre-junta nem abertura de raiz, para as seguintes posições críticas de soldagem: plana, vertical e sobrecabeça. A análise foi feita utilizando o processo de soldagem MIG/MAG por curto-circuito derivativo, GMAW-CMT (Gas Metal Arc Welding - Cold Metal Transfer), com arame AWS ER 70S-6 (1,2mm) e o gás de proteção Ar+25%CO2. O Planejamento Composto Central foi utilizado como ferramenta para a melhor organização dos testes e para análise dos resultados fez-se uma otimização utilizando a teoria de Desirability para múltiplas respostas, usando chapas planas de aço 1020 com chanfro estreito em U. Logo, valida-se esta metodologia de penetração completa em soldagem orbital de meia volta descendente em um tubo ASTM 106 por meio do processo de soldagem curto-circuito convencional com a ajuda da potência de soldagem mesurada. Os testes foram realizados com arames consumíveis de diâmetros 0,9 e 1,2 mm. Ensaios de macrografia mostraram os passes de raiz com bom aspecto visual e sem defeitos internos, sugerindo assim a possibilidade de execução da soldagem com penetração total. _______________________________________________________________________________________________ ABSTRACT
In this manuscript is presented a methodology to realize the pipe union by the welding process with the deposition of the root pass. In the butt welding execution external without open root, the height of the root face is a key factor for getting full penetration. Sometimes, copper-joints are used to prevent leaks. Though, copper can cause inclusions and corrosion, producing many troubles during the installation and generating large costs in the work area. Therefore, it was performed a penetration effect analysis using the slanted nose phase, method in root pass welding without the use of copper-joint or root opening, for the following critical welding positions: flat, vertical and overhead. The analysis was performed using the welding process MIG/MAG by derivative short circuit, GMAW-CMT (Gas Metal Arc Welding – Cold Metal Transfer), with AWS ER 70S-6 wires (1.2 mm) a with Ar+25%CO2, as shielding gas. The Central Composite Design (CCD) was used as a tool for a better organization of the tests, whereas to analyze the results it was made an optimization based on the Desirability theory for multiple responses, employing flat sheets of 1020 steel with a narrow-gap in U-shape. Then, this full penetration methodology in orbital welding turned down was validated in a ASTM 106 pipe through the conventional short-circuit welding process, with the joint established in the previous stages. The tests were performed with wires of 0.9 and 1.2 mm in order to evaluate the welding power. Macrography tests showed root pass with an acceptable visual appearance and without internal defects, thereby suggesting the possibility of welding execution with full penetration.
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Futterlieb, Elisabeth [Verfasser], Michael Werner [Akademischer Betreuer] Sereda, Beil [Gutachter] und Rainer [Gutachter] Mausberg. „Validierung einer Rehabilitationsmaßnahme bei Charcot Marie Tooth- Erkrankung (CMT) / Elisabeth Futterlieb ; Gutachter: Beil, Rainer Mausberg ; Betreuer: Michael Werner Sereda“. Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2017. http://d-nb.info/1141379414/34.
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Correa, Orphanopoulos Jorge. „Petrología y proveniencia devónica del Complejo Metamórfico Trafún , Lago Ranco, Región de los Ríos, Chile“. Tesis, Universidad de Chile, 2014. http://www.repositorio.uchile.cl/handle/2250/117068.
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GeólogoEl presente trabajo muestra la implementación de metodologías de trabajo en campo, microscopía y dataciones en circones para el estudio de las distintas fuentes de aporte y el contexto geodinámico del Complejo Metamórfico Trafún (CMT). Las metodologías consisten, en primera instancia, en una toma de datos geológicos en terreno, tales como litologías, estructuras y toma de muestras. La metodología siguiente consiste en un trabajo de microscopía óptica para estudiar la petrografía de las muestras, se estudia la mineralogía metamórfica y sus relaciones deformacionales, junto al estudio del protolito de las rocas. Se separaron en 3 tipos de rocas, metapelitas, metapsammitas y metaruditas. La información obtenida de las metapsammitas, mediante conteo modales, permite obtener diagramas de clasificación tectónica. De las metaruditas se muestrean variados clastos los cuales son descritos microscópicamente. La última metodología consiste en la obtención de edades U-Pb en circones, tanto detríticos para una metapsammita, como ígneos de un clasto de granitoide en la metarudita. Obteniendo edades de 372 Ma. para el clasto intrusivo, y edad de máxima depositación de 357 Ma. para la metapsammita junto con un fuerte aporte desde fuentes devónicas y ordovícicas.
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Olofsson, Malin. „En kognitiv semantisk analys av partikelverbet gå upp: : Conceptual Metaphor Theory (CMT) kontra Principled Polysemy Approach to Meaning Analysis (PPAMA)“. Thesis, Örebro University, Department of Humanities, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-1881.
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This essay examines the differences and similarities, weaknesses and strengths of the two Cognitive Semantic theories Conceptual Metaphor Theory and Principled Polysemy Approach to Meaning Analysis. To illustrate the two theories, the Swedish verb-particle construction "gå upp" is examined and analyzed accordingly. The results showed differences in the number of polysemous meaning found. The methodological evaluation showed that the differences in the underlying ideas concerning meaning-construction behind these two theories make them incompatible.
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Santos, Junior Milton Correia dos. „Influência da transferência metálica por curto-circuito e CMT na geometria do cordão e características da ZTA do Dual Phase DP600“. reponame:Repositório Institucional da UFPR, 2012. http://hdl.handle.net/1884/28259.
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Börjesson, Stina, und Ida Olsson. „Utvärdering av en internetbaserad CMT-kurs avseende samvetsstress, arbetsrelaterad stress, self-compassion och professionell livskvalitet hos vård- och omsorgspersonal : en genomförbarhetsstudie“. Thesis, Linnéuniversitetet, Institutionen för psykologi (PSY), 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-103738.
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Det finns överlag en brist på compassion-inriktade interventioner för vård- och omsorgspersonal. Tidigare studier tyder på att dessa interventioner ger goda resultat, men fler studier behövs. Hittills har exempelvis inga svenska studier undersökt effekter av Compassionate Mind Training (CMT) på individnivå eller med samvetsstress som utfallsmått. Studien syftade följaktligen till att undersöka om en internetbaserad CMT-kurs var en hjälpsam metod för att minska samvetsstress och arbetsrelaterad stress, samt öka självmedkänsla och professionell livskvalitet hos svensk vård- och omsorgspersonal. Studien var designad som en inomindividsstudie och utgick från en Single-Case Experimental Design (SCED), med vissa anpassningar. Totalt sex deltagare mötte inklusionskriterierna och deltog i en för- och eftermätning med självskattningsformulären Stress of Conscience Questionnaire (SCQ), Copenhagen Psychosocial Questionnaire II (COPSOQ-II), Self-Compassion Scale (SCS) och Professional Quality of Life Measure (ProQOL-5) samt fyra veckovisa mätningar under kursens gång. Slutsatsen var att CMT-kursen har varit hjälpsam i att minska samvetsstress och arbetsrelaterad stress samt i att öka självmedkänsla och professionell livskvalitet. Vidare forskning med starkare experimentell kontroll och uppföljningsmätningar behövs dock för att bekräfta resultaten.There is overall a lack of compassion-based interventions for healthcare personnel. Previous studies suggest these interventions lead to good outcomes, however there is a need for more research. There are for example no Swedish studies that have yet examined the effect of Compassionate Mind Training (CMT) either on an individual level or with stress of conscience as outcome measure. Hence, the study aimed to evaluate whether a CMT-course is a helpful method for reducing stress of conscience and work-related stress, as well as increasing self-compassion and professional quality of life for healthcare personnel. The study had a within-subject design and used a Single-Case Experimental Design (SCED) with some adjustments. Six participants met the inclusion criteria and completed Stress of Conscience Questionnaire (SCQ), Copenhagen Psychosocial Questionnaire II (COPSOQ-II), Self-Compassion Scale (SCS) and Professional Quality of Life Scale (ProQOL-5) before and after the CMT-course in addition to four weekly questionnaires during the course. The conclusion was that CMT was helpful in reducing stress of conscience and work-related stress as well as increasing self-compassion and professional quality of life. However, research with more experimental control and follow up measurements are needed to confirm the results.
ICOP
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Askling, Amber, und Phan Thanh. „Crisis Management in Covid-19 : A study in decision-making process of a crisis management team“. Thesis, Jönköping University, IHH, Företagsekonomi, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-53606.
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Background: Covid -19 pandemic affects how organizations and people operate. This crisisdiffers from previous ones due to its radical change. Organizations are threatened and strugglingto cope with the pandemic and making right decisions. This has put more attention on managementteam to address the issue at hand. This thesis explores how individuals experience crisis andmanaging it by decisions. Problem: Insufficient literature on how to make appropriate decisions in management team tocope with Covid-19 crisis. Purpose: This thesis purpose is to explore how crisis management team experience and cope withdecisions in the context of Covid-19. How individuals in a team overcome obstacles and makeappropriate decisions. Risks, uncertainty, stress, and time are previously known challenges formanagement teams. We aim to explore how these aspects affect the decision-making process. Research Question: How does crisis management team cope with Covid pandemic throughdecision-making? Method: This thesis has a qualitative research design and method of semi-structured interviewscarried out in a virtual environment due to Covid-19. Six informants have contributed to theempirical study. The empirical findings are presented in chapter 4 and analyzed by themes. Chapter5 provides discussion on the theoretical background and thesis findings, and finally conclusion inchapter 6. Conclusion: Crisis management encounters challenges with appropriate decisions for coping withCovid-19. However, our findings suggest that risk, ambiguity, and time factors are not majorchallenge and contradict this. This is due to the process of having an established crisis and makingdecisions collectively on all stages of a crisis. The most important stage of a crisis is the pre-stagewhere information is limited and guides the outcome of the whole process.
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ALLVAR, MARIE. „MIG/MAG brazing with Cold Metal Transfer“. Thesis, KTH, Maskinkonstruktion (Inst.), 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-148077.
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In the automotive industry a commonly used material is thin steel sheets coated with a thin layer of zinc for corrosion resistance purposes. Welding of this material, with the high temperatures involved, causes problems with zinc burn-off leading to reduced corrosion resistance. The zinc evaporation also causes arc disturbances leading to spatter formation, pores and difficulties achieving good visual weld quality. The joints are in many cases visible or semi-visible (e.g. visible after opening a door) and “A-grade” quality is demanded, meaning no visible discontinuities are allowed. It also implies a smooth and generally appealing appearance of the joint.An alternative to welding is brazing, and laser brazing meets the requirements but the process is associated with high costs. In the national project “LEX-B”, funded by Vinnova, the possibilities of using arc brazing, in particular one MIG/MAG brazing and two TIG brazing processes, for some automotive applications are investigated. This master thesis is connected to the first part of the project and aims at compiling data for making a selection of the most promising process to investigate and optimise further. LEX-B is conducted in cooperation between Swerea KIMAB, Volvo Trucks, Scania CV and University West. The joint of interest is a lap joint between bottom and upper sheets of 1.2 mm and 0.8 mm respectively that represents a joint on the side of a truck cabin. The requirements are visual A-grade quality and tensile shear strength of 300 MPa.In the project the MIG/MAG process Cold Metal Transfer (CMT) was compared to the TIG processes forceTIG and Plasmatron. CMT was experimentally investigated while the results for the other two processes were obtained partly from a previous study and partly from Volvo Trucks where tests were performed simultaneously. A system for measuring data for the process was developed, test specimens were brazed and examined visually and mechanical destructive testing was performed to ensure the tensile shear strength. Parameter studies were done for further process optimisation.Inom fordonsindustrin är ett ofta använt material stål i tunna ark belagda med zink p.g.a. zinkets korrossionsskyddande egenskaper. Vid svetsning av detta material uppstår problem med zink som förångas vilket leder till minskad korrosionsbeständighet. Förångningen av zink orsakar också störningar av ljusbågen vilket leder till sprut, porer och svårighet att uppnå god visuell svetskvalitet. Fogarna är i många fall synliga eller delvis synliga (t.ex. synlig efter att ha öppnat en dörr) och "A-kvalitet" efterfrågas, vilket innebär att inga synliga diskontinuiteter tillåts. Fogen ska upplevas jämn och tilltalande.Lödning är ett alternativ till svetsning, och laserlödning är en process som uppfyller kraven men är förknippad med höga kostnader. I det nationella projektet "LEX-B", som finansieras av Vinnova, undersöks möjligheterna att använda båglödning, specifikt en MIG/MAG-process och två TIG-processer, för dessa applikationer. Detta examensarbete är anslutet till den första delen av projektet och syftar till ta fram underlag för att välja den mest lovande av dessa processer för vidare utredning och optimering. LEX-B sker i samarbete mellan Swerea KIMAB, Volvo Lastvagnar, Scania CV och Högskolan Väst. Den undersökta fogen är en överlappsfog mellan en undre plåt med 1,2 mm tjocklek och en övre plåt med 0,8 mm tjocklek. Detta representerar en fog på sidan av en lastbilshytt. Kraven är visuell A-kvalitet och en drag-skjuvhållfasthet av 300 MPa.I projektet jämfördes MIG/MAG-processen Cold Metal Transfer (CMT) med TIG-processerna forceTIG och Plasmatron. CMT testades experimentellt medan resultaten för de övriga två processerna erhölls dels från tidigare tester och dels från Volvo Lastvagnar där tester utfördes parallellt. Ett mätsystem for att dokumentera processdata utvecklades och de framställda lödfogarna undersöktes visuellt och med mekanisk förstörande provning för att säkerställa drag-skjuvhållfastheten. Parameterstudier gjordes för vidare optimering av processen.
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Esteve, Clothilde. „Génétique et physiopathologie de la maladie de Charcot-Marie-Tooth de type 4H“. Thesis, Aix-Marseille, 2014. http://www.theses.fr/2014AIXM5082.
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CMT4H est une forme de CMT démyélinisant, à transmission autosomique récessive, pour laquelle notre équipe a identifié le gène responsable. Il s'agit du gène FGD4, codant pour FRABIN, protéine de 766 AA possédant 5 domaines fonctionnels: le domaine FAB de liaison à l'actine, un domaine DH responsable de l'échange GDP/GTP, et trois domaines de liaison avec des polyphosphoinositides. C'est une RhoGEF, connue pour activer les RhoGTPases Cdc42 et Rac1.Mon projet de thèse vise à mieux comprendre les bases moléculaires et les mécanismes physiopatologiques qui sous-tendent CMT4H grace à l'étudie de modèles cellulaires et murins. Dans un premier temps, j'ai identifié deux nouvelles mutations dans le gène FGD4. J'ai pu démontrer l'impact fonctionnel des mutations p.Met298fs*8 et p.Ala172Glyfs*27 et une absence totale la protéine dans les fibroblastes de ces patients, donnant lieu à une augmentation de l'activation de Cdc42.L'étude d'un modèle murin d'ablation conditionnelle de FGD4 dans les cellules de Schwann, m'a permis de démontrer la présence d' anomalies myéliniques dans le nerf périphérique de ces souris, ainsi qu'une diminution de l'activation de Cdc42.J'ai également montré, que dans les fibroblastes, FRABIN était localisée au niveau des endomembranes et que l'endocytose semblait déficient dans des cellules de patients. Finalement, l'identification de SNX3,comme partenaire protéique de FRABIN constitue un argument supplémentaire fort en faveur du rôle de FRABIN dans le trafic membranaire.La poursuite de l'étude de nos modèles et de modèles iPS ,permettra de poursuivre l'exploration de ces mécanismes et de mieux comprendre la physiopathologie de la forme CMT4HCharcot-Marie-Tooth neuropathy type 4H (CMT4H) is an inherited, autosomal recessive, peripheral neuropathy characterized by demyelination of sensory-motor nerves and due to mutations in FGD4. FGD4 encodes FRABIN, a GDP/GTP nucleotide exchange factor (GEF), specific for the GTPase Cdc42, composed of five functional domains: an N-terminal F-actin binding (FAB) domain, one Dbl homology (DH) domain, two pleckstrin homology (PH) domains, and one cysteine-rich FYVE domain.The main goal of my project is to understand the mechanisms leading to the pathology in CMT4H. To this purpose, I studied both cellular and mouse models.First, molecular screening of FGD4 allowed us to identify two additional mutations in FGD4. We also demonstrated a complete absence of the 105 kDa FRABIN isoform in patients homozygous for splicing and frameshift mutations, which unexpectedly was related to abnormally high levels of Cdc42 activation.The study of a mouse model with conditional ablation of fgd4 in Schwann cells, that we have generated, demonstrates the presence of abnormal myelin outfoldings in sciatic nerves from KO mice, which might be linked to decreased levels of Cd42 in mouse sciatic nerves. Finally, altered recycling of transferrin receptors in patients, with complete absence of FRABIN described above, as well as the identification of SNX3, a protein involved in endosomal trafficking, as a partner for FRABIN are new elements that I provide in favour of a role for FRABIN in membrane and cellular trafficking.Still, there are many points to understand, notably the relation between the RhoGTPase and the endosomal pathways, and the study of our models will help answer these questions
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Hajjar, Hélène. „Gene therapy approach on Charcot-Marie-Tooth type 1A rats“. Thesis, Montpellier, 2018. http://www.theses.fr/2018MONTT027/document.
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La myéline est une gaine formée par l’enroulement de la membrane plasmique de la cellule de Schwann autour de l’axone dans le nerf périphérique. Lorsque cette gaine est détruite, on parle de démyélinisation, cela provoque de nombreuses maladies, dont les maladies de Charcot Marie Tooth (CMT) de type 1. Les maladies CMT sont héréditaires et atteignent le système nerveux périphérique. Les symptômes communs incluent : une faiblesse musculaire, une démarche maladroite, des troubles de l’équilibre et des pieds très cambrés ou très plats. Le type le plus fréquent est la forme autosomique dominante CMT1A.Une duplication du bras court du chromosome 17 contenant le gène PMP22 (Peripheral Myelin Protein 22) induit la CMT1A. La PMP22, une petite protéine exprimée par les cellules de Schwann, est donc en excès et entraine une démyélinisation. Il existe un modèle de rats transgéniques PMP22 (ou rats CMT1A) mimant cette pathologie humaine. Les rats CMT1A surexpriment la pmp22 de souris de façon hétérozygote. Jusqu’à présent, aucun remède n’existe pour les maladies CMT. Un des traitements envisageables est la thérapie génique. Le but de mon projet de thèse était d’étudier la validité et l'efficacité de la thérapie génique chez les rats CMT1A. La stratégie consiste à réduire la surexpression de la protéine PMP22 chez le rat CMT1A à l’aide d’ARNsh anti-PMP22. Pour ne pas être détruits par l’organisme et maintenir une expression longue, ces ARN sh-PMP22 sont transférés chez le rat grâce à des vecteurs viraux dérivés de virus adéno-associés, ou AAV (pour adeno-associated virus). Nous avons donc injecté un des différents sérotypes d'AAV,l'AAV9 exprimant les ARN sh-PMP22 de souris ainsi que la GFP comme marqueur des cellules infectées dans les nerfs sciatiques de rats CMT1A à l’âge de 6 jours ou 7 jours.Nous avons d’abord confirmé que les virus thérapeutiques infectaient une très large proportion de cellules de Schwann dans le nerf sciatique de rat CMT1A et ensuite que l’infection de ces cellules par les virus exprimant les ARN sh-PMP22 induisait une diminution significative de l’expression de la protéine PMP22. L'analyse du phénotype moteur des rats CMT1A traités avec les AAV9 exprimant les ARN sh-PMP22 montre que les rats CMT1A traités ne développent pas la maladie observée dans les contrôles. Également, les rats CMT1A présentent une hypoalgésie, un phénotype qui n’apparait pas dans les CMT1A traités avec les vecteurs thérapeutiques. Le traitement par thérapie génique empêche la réduction de la vitesse de conduction nerveuse observé dans les rats malades. Concernant la biodistribution des virus, 2,5 mois après le traitement, en dehors des nerfs sciatiques ou les virus ont été injectés, le virus était présent dans les muscles qui entourent le nerf et aussi dans quelques ganglion dorsaux. Pour la réponse immunitaire,les rats injectés, à seulement 2 exceptions près, n’ont pas développé de facteurs neutralisants anti-AAV9. Cette thérapie génique pourrait être utilisée dans les essais cliniques.Avant de passer aux études cliniques pour le traitement de la maladie CMT1A à l’aide d’AAV9 exprimant des ARN sh-PMP22 humain, la dose d’expression de ce ARN sh-PMP22 doit être très soigneusement déterminée car si la PMP22 est trop réduite, une autre maladie peut se développer, la neuropathie héréditaire avec hypersensibilité à la pression. Il est aussi important d’avoir un outil bien adapté qui permet d’évaluer l’efficacité du traitement. Aucun existant n’est assez fiable pour mesurer la myéline du nerf périphérique. Pour remédier à ce manque, nous avons testé la technique d'imagerie Coherent Anti-stokes Raman Scattering (CARS) en caractérisant avec succès les défauts de la myéline. Par conséquent, le CARS est une technique prometteuse permettant d’évaluer l’avancement des maladies de la myéline et l’efficacité de nouvelles thérapies pour les neuropathies périphériques démyélinisantesMyelin, a tissue synthesized by Schwann cells, covers and protects nerves. If damaged, it causes many demyelinating diseases such as the inherited peripheral nervous system disorder Charcot Marie Tooth or CMT type 1. CMT neuropathies display a large variability from one patient to another. Nevertheless, the most common symptoms include muscle weakness, an awkward way of walking (gait), equilibrium problem and highly arched or very flat feet. The most common subtype of CMT is an autosomal dominant disorder known as CMT1A. CMT1A is caused by the duplication of the peripheral myelin protein 22 (PMP22) gene on the short arm of chromosome 17 (17p11.2) resulting in an excess of PMP22. This leads to demyelination. PMP22 is a small protein expressed by Schwann cells. There is still no cure for CMT diseases. One approach for a treatment is gene therapy. The aim of my thesis project was to deliver proof of principle for a gene therapy approach on a CMT1A rat model characterized by extra copies of mouse pmp22 gene (CMT1A rat). The treatment strategy consisted in reducing PMP22 overexpression in CMT1A rats with shRNA against PMP22. Viral vectors like adeno-associated virus (AAV having serotypes from1-10) are used to deliver shRNA in vivo so that they won’t be destroyed by the organism and for them to be long-lasting. Thus, we injected sciatic nerves of 6-7-day-old CMT1A rats with AAV9 expressing shRNA PMP22 with a GFP marker. We first confirmed that the virus highly transduced Schwann cells and that AAV9 shRNA PMP22 decreased PMP22 protein expression in CMT1A rats’ sciatic nerves. CMT1A rats treated with AAV9 shRNA PMP22 showed that they didn’t develop the motor phenotype seen in controls. Moreover, hypoalgesia observed in CMT1A rats was alleviated by treatment. In addition, gene therapy increased the reduced nerve conduction velocity found in CMT1A rats. Concerning safety, no viral off-targets were detected except in muscles close to the injection site (sciatic nerve) and in the dorsal root ganglions. Except for 2 rats, there was no immune response against AAV; no anti-AAV9 neutralizing factors. Consequently, this gene therapy could be used in clinical trials. Before moving to clinical studies, the minimal effective dosage should be very carefully defined because if PMP22 is completely deleted, another disease is caused: Hereditary Neuropathy with Pressure Palsies. It is also crucial to have a strong readout to evaluate the outcome of a treatment. However, no tool consistent enough exists for examining the peripheral nerve. Thus, we tested the label-free imaging technique Coherent Anti-stokes Raman Scattering (CARS) and successfully characterized myelination defects. Consequently, CARS could be used as a consistent outcome measure for developing new therapies for demyelinating peripheral neuropathies
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Bandaru, Rammohan, und Debashis Barman. „Performance Evaluation of SCTP as a Transport Layer Protocol“. Thesis, Högskolan i Halmstad, Sektionen för Informationsvetenskap, Data– och Elektroteknik (IDE), 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-16003.
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TCP and UDP are the most popular transport protocols used for end-end data transmission. The rapid growth of internet leads to development of many innovative applications in the current environment. Depending on the functionality of these applications, requirements of transport protocols are changing. TCP is known for its problems with Head Of Line blocking (HOL) and SYN attacks which gives reduced performance, and also doesn’t support Multi-Homing. SCTP is another transport layer protocol similar to TCP which provides end-end communication. It has some unique features like support for Multi-homing and multi-streaming. It also protects better from SYN attacks by using four-way hand shake mechanism during association establishment. As an extension to SCTP, CMT-SCTP was proposed to take full advantage of a multi-homed host by doing load sharing over multiple paths. SCTP is believed to be a next generation transport protocol. This thesis gives an overview of the SCTP protocol and its features focusing on analysing and testing of failover mechanisms provided by SCTP in multi-homed host, evaluating the transmission performance of SCTP vs TCP in a real network environment. This report also gives a theoretical analysis on how SCTP can mitigate SYN attacks by using four-way handshake mechanism and the state of art of CMT-SCTP.
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McVicker, Nathaniel P. „Structural Weld Overlays for Mitigation of Primary Water Stress Corrosion in Nuclear Power Plants“. The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1429879662.
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Hrádek, Jan. „Procesní parametry při navařování Inconelu 625“. Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2021. http://www.nusl.cz/ntk/nusl-443210.
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The research is focused on cladding of inconel 625 using the MAG - CMT method. It was found that welding without an oscillation does not create the necessary geometry to establish additional layers. When welding with an oscillation, it was researched that the current between 150 and 200 A appears most appropriate in the synergistic mode for welding inconel 625. The resulting weld bead was made at a current of 190 A with pulse dynamics correction set to -4 and correction of arc length to +10 and welding speed of 315 mm per minute.The weld bead was not ideal mainly due to insufficient height. The improvement of results could be achieved by set oscilation with fluent change in acceleration. Because of the time options and difficulty of programming it was used only constant speed for all experiments.
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Zhang, Yanling. „The roles and regulation of phosphatidylinositol 3,5-bisphosphates in mammals“. Diss., University of Iowa, 2008. http://ir.uiowa.edu/etd/1.
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Terry, Adeline Sophie Amélie. „L'expression métaphorique des tabous : entre euphémisme et dysphémisme : étude linguistique d'un corpus de séries télévisées américaines“. Thesis, Lyon, 2019. http://www.theses.fr/2019LYSE3024.
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Ce travail propose d’étudier les relations complexes entre métaphore, tabou et X phémisme. Plus spécifiquement, il analyse la manière dont les domaines tabous de la maladie, de la mort et du sexe sont représentés par le biais de la métaphore dans un corpus de séries télévisées américaines constitué de House, M.D., Grey’s Anatomy, Six Feet Under, How I Met your Mother et Sex and the City. Il s’articule autour de trois chapitres. Les deux premiers permettent de définir le cadre théorique. Dans un premier temps, nous définissons le concept de « tabou » et tentons de dégager les origines historiques et sociales des tabous étudiés. Cela nous mène également à définir les X phémismes – qui sont privilégiés pour mentionner les sujets tabous – et les différentes matrices lexicogéniques qui permettent leur création. Le second chapitre est consacré à la définition de la matrice qui nous intéresse dans le cadre de ce travail : la métaphore. Il adopte une approche cognitiviste et vise essentiellement à exposer le cadre théorique relatif à la métaphore qui est utilisé dans le dernier chapitre. Enfin, le troisième chapitre propose une analyse des métaphores relevées dans le corpus. Il s’agit d’étudier l’influence du domaine source sur la conceptualisation X phémique et les différentes fonctions que peuvent revêtir ces métaphores. Tout au long de ce travail, nous nous attachons à expliquer en quoi les métaphores sont un outil privilégié pour la création de métaphores relatives à des sujets tabous et à réfléchir sur le statut particulier des métaphores dans les séries téléviséesThis study explores the complex relations between metaphor, taboos, and X phemisms. More specifically, it focuses on the representation of the taboos of disease, death, and sex through metaphors in a corpus constituted of five American TV series, House, M.D., Grey’s Anatomy, Six Feet Under, How I Met your Mother et Sex and the City. It is divided into three chapters. The first two chapters aim to define the theoretical framework. The study starts with a definition of the concept of “taboo” and its social and historical origins. It leads us to a definition of X phemisms – which are favored to mention taboo topics – and the different word-formation processes that are used for their creation. The second chapter is devoted to the definition of the word-formation process that is central in this study: metaphor. The approach is mainly cognitivist and the aim of the chapter is to define the Conceptual Metaphor Theory. Finally, the last chapter consists in an analysis of the metaphors of the corpus. The aim is to study the influence of the source domains on the creation of metaphorical X phemisms and the different functions that those metaphors may fulfil. One of the main objectives is to explain why metaphors are favored to create metaphors related to taboo topics and to shed light on the particular status of metaphors in TV series