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Thematische Bibliographien / Complex engineered system / Dissertationen

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Dissertationen zum Thema „Complex engineered system“

Autor: Grafiati

Veröffentlicht am 26. Juni 2021

Zuletzt aktualisiert am 9. Februar 2022

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1

Abbas, Manzar. "System-level health assessment of complex engineered processes." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/37260.

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Condition-Based Maintenance (CBM) and Prognostics and Health Management (PHM) technologies aim at improving the availability, reliability, maintainability, and safety of systems through the development of fault diagnostic and failure prognostic algorithms. In complex engineering systems, such as aircraft, power plants, etc., the prognostic activities have been limited to the component-level, primarily due to the complexity of large-scale engineering systems. However, the output of these prognostic algorithms can be practically useful for the system managers, operators, or maintenance personnel

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Haraszti, Reka A. "Engineered Exosomes for Delivery of Therapeutic siRNAs to Neurons." eScholarship@UMMS, 2018. https://escholarship.umassmed.edu/gsbs_diss/971.

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Extracellular vesicles (EVs), exosomes and microvesicles, transfer endogenous RNAs between neurons over short and long distances. We have explored EVs for siRNA delivery to brain. (1) We optimized siRNA chemical modifications and siRNA conjugation to lipids for EV-mediated delivery. (2) We developed a GMP-compatible, scalable method to manufacture active EVs in bulk. (3) We characterized lipid and protein content of EVs in detail. (4) We established how protein and lipid composition relates to siRNA delivering activity of EVs, and we reverse engineered natural exosomes (small EVs) into artific

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Hambley, Chris J. "Multilevel design for complex engineered systems." Thesis, University of Sheffield, 2018. http://etheses.whiterose.ac.uk/22673/.

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Efatmaneshnik, Mahmoud Mechanical &amp Manufacturing Engineering Faculty of Engineering UNSW. "Towards immunization of complex engineered systems: products, processes and organizations." Publisher:University of New South Wales. Mechanical & Manufacturing Engineering, 2009. http://handle.unsw.edu.au/1959.4/43358.

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Engineering complex systems and New Product Development (NPD) are major challenges for contemporary engineering design and must be studied at three levels of: Products, Processes and Organizations (PPO). The science of complexity indicates that complex systems share a common characteristic: they are robust yet fragile. Complex and large scale systems are robust in the face of many uncertainties and variations; however, they can collapse, when facing certain conditions. This is so since complex systems embody many subtle, intricate and nonlinear interactions. If formal modelling exercises with

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Hubbard, Ella-Mae. "Supporting the Configuration of Decision-Making Systems for Complex, Long-Life Engineered Systems." Thesis, Loughborough University, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.519717.

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6

Agarwal, Kuldeep. "Physics Based Hierarchical Decomposition of Processes for Design of Complex Engineered Systems." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1322152146.

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Di, Federico Erica. "Complex mechanical conditioning of cell-seeded constructs can influence chondrocyte activity." Thesis, Queen Mary, University of London, 2014. http://qmro.qmul.ac.uk/xmlui/handle/123456789/7982.

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Articular cartilage represents a primary target for tissue engineering strategies as it does not functionally regenerate within the joint. Many tissue engineering approaches have focused on the in vitro generation of neo-cartilage using chondrocyte-seeded scaffolds. Several studies have reported the morphological appearance of native cartilage, although its functional competence has not been demonstrated. Accordingly, mechanical conditioning has often been introduced to enhance biosynthetic activity of chondrocytes within 3D constructs. However although this strategy has significantly up-regul

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Alfaris, Anas (Anas Faris). "The Evolutionary Design Model (EDM) for the design of complex engineered systems : Masdar City as a case study." Thesis, Massachusetts Institute of Technology, 2009. http://hdl.handle.net/1721.1/58187.

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Thesis (S.M.)--Massachusetts Institute of Technology, Computation for Design and Optimization Program, 2009.<br>"September 2009." Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 150-157).<br>This thesis develops a framework for constructing an Evolutionary Design Model (EDM) that would enhance the design of complex systems through an efficient process. The framework proposed is generic and suggests a group of systematic methodologies that eventually lead to a fully realized and integrated design model. Within this model, complexities of the design are handled a

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Taylor, James Edward Nathan. "Biochemical and biophysical characterisation of the genetically engineered Type I restriction-modification system, EcoR124I NT." Thesis, University of Portsmouth, 2005. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424193.

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The EcoR124INT restriction-modification (R-M) system contains the genes HsdS3, HsdM and HsdR. S3 encodes the N-terminal domain of the wild-type S subunit and has been shown to dimerise in solution (Smith et al., 1998). Following purification of the subunits of the EcoR124INT R-M system, complexes of the methyltransferase S3/M and restriction endonuclease S3/M/R were formed and shown to have activity in vitro, methylating and hydrolysing a symmetrical DNA recognition sequence, respectively. The DNA mimic OCR (overcome classical restriction) protein inhibited the methyltransferase activity in vi

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Sprauer, William A. "Self-organization and Sense-making in Architect-Engineer Design Teams| Leveraging Health Care's Approach to "Managing" Complex Adaptive Systems." Thesis, The George Washington University, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10126014.

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<p>Traditional, corporate-level risk mitigation procedures and management-led performance improvement efforts tend to ignore the relationship dynamics of Architect-Engineer design teams, and instead focus on the credentials and abilities of the individual designers, the contractual framework surrounding the individual projects, and the process for inspecting and controlling the quality of the team’s output, the design. Management may tacitly acknowledge the complex nature of the design process, but the notion of design teams as complex systems, or more precisely, Complex Adaptive Systems

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Soleimani, Morteza, I. Felician Campean, and Daniel Neagu. "Diagnostics and prognostics for complex systems: A review of methods and challenges." 2021. http://hdl.handle.net/10454/18581.

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Yes<br>Diagnostics and prognostics have significant roles in the reliability enhancement of systems and are focused topics of active research. Engineered systems are becoming more complex and are subjected to miscellaneous failure modes that impact adversely their performability. This everincreasing complexity makes fault diagnostics and prognostics challenging for the system-level functions. A significant number of successes have been achieved and acknowledged in some review papers; however, these reviews rarely focused on the application of complex engineered systems nor provided a sys

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Soleimani, Morteza, I. Felician Campean, and Daniel Neagu. "Integration of Hidden Markov Modelling and Bayesian Network for Fault Detection and Prediction of Complex Engineered Systems." 2021. http://hdl.handle.net/10454/18518.

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yes<br>This paper presents a methodology for fault detection, fault prediction and fault isolation based on the integration of hidden Markov modelling (HMM) and Bayesian networks (BN). This addresses the nonlinear and non-Gaussian data characteristics to support fault detection and prediction, within an explainable hybrid framework that captures causality in the complex engineered system. The proposed methodology is based on the analysis of the pattern of similarity in the log-likelihood (LL) sequences against the training data for the mixture of Gaussians HMM (MoG-HMM). The BN model iden

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"An Agent-Based Optimization Framework for Engineered Complex Adaptive Systems with Application to Demand Response in Electricity Markets." Doctoral diss., 2013. http://hdl.handle.net/2286/R.I.18700.

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abstract: The main objective of this research is to develop an integrated method to study emergent behavior and consequences of evolution and adaptation in engineered complex adaptive systems (ECASs). A multi-layer conceptual framework and modeling approach including behavioral and structural aspects is provided to describe the structure of a class of engineered complex systems and predict their future adaptive patterns. The approach allows the examination of complexity in the structure and the behavior of components as a result of their connections and in relation to their environment. This r

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(5929472), Diane C. Aloisio. "Lessons from Systems Engineering Failures: Determining Why Systems Fail, the State of Systems Engineering Education, and Building an Evidence-Based Network to Help Systems Engineers Identify and Fix Problems on Complex Projects." Thesis, 2019.

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As the complexity of systems increases, so does what can go wrong with them. For example, the United States Air Force selected McDonnell Douglas’ design for the F-15 Eagle fighter aircraft in 1967 and the aircraft’s first test flight was in 1972, 5 years later. In contrast, the US military selected Lockheed Martin as one of two companies to develop the F-35 Lightning II in 1997 and its first flight was in 2006, 9 years later, and the first production aircraft had its first flight in 2011, 14 years after the selection. This complex program’s problems have been well-documented by the U.S. Govern

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Hill, Barry R. "Eliciting, analyzing, and comparing mental models of complex audio recording systems between professional and novice recording engineers." 2006. http://etda.libraries.psu.edu/theses/approved/WorldWideIndex/ETD-1248/index.html.

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(6564809), Elisabeth Krueger. "Dynamics of Coupled Natural-Human-Engineered Systems: An Urban Water Perspective on the Sustainable Management of Security and Resilience." Thesis, 2019.

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<div>The security, resilience and sustainability of water supply in urban areas are of major concern in cities around the world. Their dynamics and long-term trajectories result from external change processes, as well as adaptive and maladaptive management practices aiming to secure urban livelihoods. This dissertation examines the dynamics of urban water systems from a social-ecological-technical systems perspective, in which infrastructure and institutions mediate the human-water-ecosystem relationship. </div><div><br></div><div>The three concepts of security, resilience and sustainability a

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