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Thematische Bibliographien / Complex engineered system / Zeitschriftenartikel

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Zeitschriftenartikel zum Thema „Complex engineered system“

Autor: Grafiati

Veröffentlicht am 26. Juni 2021

Zuletzt aktualisiert am 29. Juli 2025

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1

Mehrpouyan, Hoda, Brandon Haley, Andy Dong, Irem Y. Tumer, and Christopher Hoyle. "Resiliency analysis for complex engineered system design." Artificial Intelligence for Engineering Design, Analysis and Manufacturing 29, no. 1 (2015): 93–108. http://dx.doi.org/10.1017/s0890060414000663.

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AbstractResilience is a key driver in the design of systems that must operate in an uncertain operating environment, and it is a key metric to assess the capacity for systems to perform within the specified performance envelop despite disturbances to their operating environment. This paper describes a graph spectral approach to calculate the resilience of complex engineered systems. The resilience of the design architecture of complex engineered systems is deduced from graph spectra. This is calculated from adjacency matrix representations of the physical connections between components in comp

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Liu, Boyuan, Shuangxi Huang, Wenhui Fan, et al. "Data driven uncertainty evaluation for complex engineered system design." Chinese Journal of Mechanical Engineering 29, no. 5 (2016): 889–900. http://dx.doi.org/10.3901/cjme.2016.0422.058.

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Banerjee, Soumya. "Lymph node inspired computing: towards immune system inspired human-engineered complex systems." Interdisciplinary Description of Complex Systems 19, no. 4 (2021): 502–10. http://dx.doi.org/10.7906/indecs.19.4.4.

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McIntire, Matthew G., Christopher Hoyle, Irem Y. Tumer, and David C. Jensen. "Safety-informed design: Using subgraph analysis to elicit hazardous emergent failure behavior in complex systems." Artificial Intelligence for Engineering Design, Analysis and Manufacturing 30, no. 4 (2016): 466–73. http://dx.doi.org/10.1017/s089006041600041x.

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AbstractIdentifying failure paths and potentially hazardous scenarios resulting from component faults and interactions is a challenge in the early design process. The inherent complexity present in large engineered systems leads to nonobvious emergent behavior, which may result in unforeseen hazards. Current hazard analysis techniques focus on single hazards (fault trees), single faults (event trees), or lists of known hazards in the domain (hazard identification). Early in the design of a complex system, engineers may represent their system as a functional model. A function failure reasoning

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Basole, Rahul C., Ahsan Qamar, Hyunwoo Park, Christiaan J. J. Paredis, and Leon F. McGinnis. "Visual Analytics for Early-Phase Complex Engineered System Design Support." IEEE Computer Graphics and Applications 35, no. 2 (2015): 41–51. http://dx.doi.org/10.1109/mcg.2015.3.

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Skreddernes, Ola, Rune André Haugen, and Cecilia Haskins. "Coping with Verification in Complex Engineered Product Development." INCOSE International Symposium 33, no. 1 (2023): 482–502. http://dx.doi.org/10.1002/iis2.13034.

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AbstractCoping with system verification in complex systems is a challenging task. This paper reports on how the high complexity of closely integrated systems and long timelines in development affects the verification process in an engineering company in Norway. The literature on verification in development and a survey within the industry‐as‐laboratory method were used to research the practice of verification in the case company to identify where the company's practice deviates from the recommended practice according to the literature. The research found that the company is taking shortcuts in

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Dimauro, G., S. Impedovo, G. Pirlo, and A. Salzo. "Automatic Bankcheck Processing: A New Engineered System." International Journal of Pattern Recognition and Artificial Intelligence 11, no. 04 (1997): 467–504. http://dx.doi.org/10.1142/s0218001497000214.

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A new bankcheck processing system is presented in this paper. A full exploitation of the contextual knowledge, together with a multi-expert approach, have been used both to analyze the complex shape of handwritten text and to design the system. Several processing modules have been integrated in the system. Some of the most relevant are those for data acquisition, preprocessing, machine-printed numeral recognition, layout analysis, courtesy amount recognition, legal amount recognition, amount validation, and signature verification. Some combination techniques have also been used in the system.

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Keating, Charles B., Polinpapilinho F. Katina, Joseph M. Bradley, Richard Hodge, and James C. Pyne. "Sustainability: A Complex System Governance Perspective." INCOSE International Symposium 33, no. 1 (2023): 1117–31. http://dx.doi.org/10.1002/iis2.13073.

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AbstractThis paper explores the sustainability field from a Complex System Governance (CSG) perspective. In general, sustainability suggests maintenance at a specific rate or level. It is also frequently held as maintaining ecological balance to negate the depletion of natural resources. CSG offers sustainability a theoretically grounded, model based, and methodologically sound approach to better inform sustainability design, execution, and development for complex systems. CSG examines sustainability as an outcome‐based product resulting from effective governance of an underlying system which

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Keating, Charles B., Polinpapilinho F. Katina, Joseph M. Bradley, Richard Hodge, and James C. Pyne. "Sustainability: A Complex System Governance Perspective." INSIGHT 27, no. 1 (2024): 8–17. http://dx.doi.org/10.1002/inst.12471.

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ABSTRACTThis paper explores the sustainability field from a complex system governance (CSG) perspective. In general, sustainability suggests maintenance at a specific rate or level. It is also frequently held as maintaining ecological balance to negate the depletion of natural resources. CSG offers sustainability a theoretically grounded, model based, and methodologically sound approach to better inform sustainability design, execution, and development for complex systems. CSG examines sustainability as an outcome‐based product resulting from effective governance of an underlying system which

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Sun, Eric D., Thomas C. T. Michaels, and L. Mahadevan. "Optimal control of aging in complex networks." Proceedings of the National Academy of Sciences 117, no. 34 (2020): 20404–10. http://dx.doi.org/10.1073/pnas.2006375117.

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Many complex systems experience damage accumulation, which leads to aging, manifest as an increasing probability of system collapse with time. This naturally raises the question of how to maximize health and longevity in an aging system at minimal cost of maintenance and intervention. Here, we pose this question in the context of a simple interdependent network model of aging in complex systems and show that it exhibits cascading failures. We then use both optimal control theory and reinforcement learning alongside a combination of analysis and simulation to determine optimal maintenance proto

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Sarkar, Kathakali, Deepro Bonnerjee, Rajkamal Srivastava, and Sangram Bagh. "A single layer artificial neural network type architecture with molecular engineered bacteria for reversible and irreversible computing." Chemical Science 12, no. 48 (2021): 15821–32. http://dx.doi.org/10.1039/d1sc01505b.

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We created artificial neural network type architecture with engineered bacteria to perform reversible and irreversible computation. This may work as new computing system for performing complex cellular computation.

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Raz, Ali K., William Miller, Kuo‐Chu Chang, Yan Lin, and Erik Blasch. "Explainable AI and Counterfactuals for Test and Evaluation of Intelligent Engineered Systems." INCOSE International Symposium 33, no. 1 (2023): 1524–39. http://dx.doi.org/10.1002/iis2.13096.

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AbstractSystems Engineering (SE) based test and evaluation (T&E) approaches have proven crucial for successful realization of most modern‐day complex systems and system‐of‐systems solutions. The design, test, and evaluation of engineered systems with many technologically advanced and complex components hinges on well‐structured integration and life cycle evolution process models, clearly defined requirements, along with controllability, observability, and stability (COS) of components that transcend to the system‐level. However, integration of machine learning (ML), deep learning (DL) and

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Walsh, Hannah Scharline, Andy Dong, Irem Tumer, and Guillaume Brat. "DETECTING AND CHARACTERIZING PATTERNS OF FAILURE IN COMPLEX ENGINEERED SYSTEMS: AN ONTOLOGY DEVELOPMENT AND CLUSTERING APPROACH." Proceedings of the Design Society 3 (June 19, 2023): 1425–34. http://dx.doi.org/10.1017/pds.2023.143.

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AbstractWhile the causes of failures in complex engineered systems are often clear in hindsight, it can be challenging to predict failures proactively during the design of novel engineered products or systems. Identifying patterns can be useful for capturing common characteristics that may lead to failure. In this paper, we present a methodology for identifying patterns of failure from NASA's publicly available Lessons Learned Information System (LLIS). We apply an ontology development and clustering approach to identify representative patterns leading to failures in historical lessons learned

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Hori, Tetsuya, Wei-Hao Shang, Kozo Takeuchi, and Tatsuo Fukagawa. "The CCAN recruits CENP-A to the centromere and forms the structural core for kinetochore assembly." Journal of Cell Biology 200, no. 1 (2012): 45–60. http://dx.doi.org/10.1083/jcb.201210106.

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CENP-A acts as an important epigenetic marker for kinetochore specification. However, the mechanisms by which CENP-A is incorporated into centromeres and the structural basis for kinetochore formation downstream of CENP-A remain unclear. Here, we used a unique chromosome-engineering system in which kinetochore proteins are targeted to a noncentromeric site after the endogenous centromere is conditionally removed. Using this system, we created two distinct types of engineered kinetochores, both of which were stably maintained in chicken DT40 cells. Ectopic targeting of full-length HJURP, CENP-C

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Thorat, Mr Vaibhav, and Mr Samyak Parekar. "Pre Engineering Building as a Modern Era: A Review." International Journal for Research in Applied Science and Engineering Technology 10, no. 3 (2022): 1716–21. http://dx.doi.org/10.22214/ijraset.2022.40955.

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Abstract: Now A Days the cost and time of construction is in more priority for the client with the large working area for various uses. For the economically and minimum loss of material, pre-engineered building system (PEBs) has many advantage, because it gives more column free space at low cost. Pre-engineered metal buildings are more reliable for various uses like complex industrial facilities, warehouses and distribution centres, stock-house, shopping malls, resort, motor court, office, cabin, service complex, aircraft-hanger, athletics and fun stadium, study places, temples, hospitals, and

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Chavez, Alejandro, Benjamin W. Pruitt, Marcelle Tuttle, et al. "Precise Cas9 targeting enables genomic mutation prevention." Proceedings of the National Academy of Sciences 115, no. 14 (2018): 3669–73. http://dx.doi.org/10.1073/pnas.1718148115.

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Here, we present a generalized method of guide RNA “tuning” that enables Cas9 to discriminate between two target sites that differ by a single-nucleotide polymorphism. We employ our methodology to generate an in vivo mutation prevention system in which Cas9 actively restricts the occurrence of undesired gain-of-function mutations within a population of engineered organisms. We further demonstrate that the system is scalable to a multitude of targets and that the general tuning and prevention concepts are portable across engineered Cas9 variants and Cas9 orthologs. Finally, we show that the mut

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Christensen, G., Y. Wang, and K. R. Chien. "Physiological assessment of complex cardiac phenotypes in genetically engineered mice." American Journal of Physiology-Heart and Circulatory Physiology 272, no. 6 (1997): H2513—H2524. http://dx.doi.org/10.1152/ajpheart.1997.272.6.h2513.

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The recent development of techniques for surgical manipulation and for the assessment of cardiac physiology in genetically engineered mice has allowed scientists to address some of the most fundamental questions related to congenital and acquired forms of human heart disease. This review discusses recent advances in the techniques for studying cardiac disease using the mouse as a model system. Because cardiac overload is one of the most important stimuli for development of hypertrophy and heart failure in humans, various models of cardiac pressure and volume overload, as well as myocardial isc

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Katina, Polinpapilinho F., Charles B. Keating, James A. Bobo, and Tyrone S. Toland. "A Governance Perspective for System-of-Systems." Systems 7, no. 4 (2019): 54. http://dx.doi.org/10.3390/systems7040054.

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The operating landscape of 21st century systems is characteristically ambiguous, emergent, and uncertain. These characteristics affect the capacity and performance of engineered systems/enterprises. In response, there are increasing calls for multidisciplinary approaches capable of confronting increasingly ambiguous, emergent, and uncertain systems. System of Systems Engineering (SoSE) is an example of such an approach. A key aspect of SoSE is the coordination and the integration of systems to enable ‘system-of-systems’ capabilities greater than the sum of the capabilities of the constituent s

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Burg, Timothy, Cheryl A. P. Cass, Richard Groff, Matthew Pepper, and Karen J. L. Burg. "Building off-the-shelf tissue-engineered composites." Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 368, no. 1917 (2010): 1839–62. http://dx.doi.org/10.1098/rsta.2010.0002.

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Rapid advances in technology have created the realistic possibility of personalized medicine. In 2000, Time magazine listed tissue engineering as one of the ‘hottest 10 career choices’. However, in the past decade, only a handful of tissue-engineered products were translated to the clinical market and none were financially viable. The reality of complex business planning and the high-investment, high-technology environment was not apparent, and the promise of tissue engineering was overstated. In the meantime, biologists were steadily applying three-dimensional benchtop tissue-culture systems

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Jacobson, Lindsey, and Scott Ferguson. "A HIERARCHICAL EXPLORATION OF HOW DESIGN MARGINS ENABLE ADAPTABILITY." Proceedings of the Design Society 3 (June 19, 2023): 191–200. http://dx.doi.org/10.1017/pds.2023.20.

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AbstractOur society is built on engineered systems. Engineers are becoming increasingly concerned with the sustainability of systems, particularly their ability to adapt to a changing world. Recently, there has been increased interest in exploring how design margins provide opportunities for a system change. There have been great developments in determining how design margins can absorb change at a system level, but it is still not clear how design margins might provide change opportunities at a decision variable level. In this paper, we show how system-level margins could be deconstructed to

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Chhun, Audam, Silvia Moriano-Gutierrez, Florian Zoppi, Amélie Cabirol, Philipp Engel, and Yolanda Schaerli. "An engineered bacterial symbiont allows noninvasive biosensing of the honey bee gut environment." PLOS Biology 22, no. 3 (2024): e3002523. http://dx.doi.org/10.1371/journal.pbio.3002523.

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The honey bee is a powerful model system to probe host–gut microbiota interactions, and an important pollinator species for natural ecosystems and for agriculture. While bacterial biosensors can provide critical insight into the complex interplay occurring between a host and its associated microbiota, the lack of methods to noninvasively sample the gut content, and the limited genetic tools to engineer symbionts, have so far hindered their development in honey bees. Here, we built a versatile molecular tool kit to genetically modify symbionts and reported for the first time in the honey bee a

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Zhang, He, Junming Sun, Ding Ma, Gisela Weinberg, Dang Sheng Su, and Xinhe Bao. "Engineered Complex Emulsion System: Toward Modulating the Pore Length and Morphological Architecture of Mesoporous Silicas." Journal of Physical Chemistry B 110, no. 51 (2006): 25908–15. http://dx.doi.org/10.1021/jp065760w.

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Camenen, B., G. Naudet, G. Dramais, J. Le Coz, and A. Paquier. "A multi-technique approach for evaluating sand dynamics in a complex engineered piedmont river system." Science of The Total Environment 657 (March 2019): 485–97. http://dx.doi.org/10.1016/j.scitotenv.2018.11.394.

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Sattarova, Kseniya T., Victoria V. Kokareva, and Nikolay D. Pronichev. "The Ratio-Delay Method of the Manufacturing System Analysis." Applied Mechanics and Materials 770 (June 2015): 641–44. http://dx.doi.org/10.4028/www.scientific.net/amm.770.641.

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This paper describes the application of a ratio-delay to a study of operations of mechanical Job-Shop production in Samara factory. To analyze the operations efficiency it may be necessary to obtain organizational and technical data in each job stages. In fact, ratio-delay is an effective tool to determine direct labor productivity for shop floor activities. In the context of manufacturing operations, ratio-delay can determine productivity levels as a baseline that provides focus for new “industrial engineered” improvement measures of complex re-engineering project or lean management.

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Nguyen, Huu Tuan, Arne Peirsman, Zuzana Tirpakova, et al. "Engineered Vasculature for Cancer Research and Regenerative Medicine." Micromachines 14, no. 5 (2023): 978. http://dx.doi.org/10.3390/mi14050978.

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Engineered human tissues created by three-dimensional cell culture of human cells in a hydrogel are becoming emerging model systems for cancer drug discovery and regenerative medicine. Complex functional engineered tissues can also assist in the regeneration, repair, or replacement of human tissues. However, one of the main hurdles for tissue engineering, three-dimensional cell culture, and regenerative medicine is the capability of delivering nutrients and oxygen to cells through the vasculatures. Several studies have investigated different strategies to create a functional vascular system in

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Shegogue, Daniel, and W. Jim Zheng. "Object-oriented biological system integration: a SARS coronavirus example." Bioinformatics 21, no. 10 (2005): 2502–9. http://dx.doi.org/10.1093/bioinformatics/bti344.

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Abstract Motivation The importance of studying biology at the system level has been well recognized, yet there is no well-defined process or consistent methodology to integrate and represent biological information at this level. To overcome this hurdle, a blending of disciplines such as computer science and biology is necessary. Results By applying an adapted, sequential software engineering process, a complex biological system (severe acquired respiratory syndrome-coronavirus viral infection) has been reverse-engineered and represented as an object-oriented software system. The scalability of

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Elham, Keshavarzi, Goebel Kai, Y. Tumer Irem, and Hoyle Christopher. "Failure Analysis in Conceptual Phase toward a Robust Design: Case Study in Monopropellant Propulsion System." International Journal of Research and Engineering 5, no. 9 (2018): 535–46. https://doi.org/10.21276/ijre.2018.5.9.7.

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As a system becomes more complex, the uncertainty in the operating conditions increases. In such a system, implementing a precise failure analysis in early design stage is vital. However, there is a lack of applicable methodology that shows how to implement failure analysis in the early design phase to achieve a robust design. The main purpose of this paper is to present a framework to design a complex engineered system resistant against various factors that may cause failures, when design process is in the conceptual phase and information about detailed system and component is unavailable. Wi

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Olivieri, Federico, Rachele Castaldo, Mariacristina Cocca, Gennaro Gentile, and Marino Lavorgna. "Innovative silver-based capping system for mesoporous silica nanocarriers able to exploit a two-fold anticorrosive mechanism in composite polymer coatings: tailoring benzotriazole release and capturing chloride ions." ACS Appl. Mater. Interfaces 13, no. 40 (2021): 48141–52. https://doi.org/10.1021/acsami.1c15231.

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In this work, engineered stimuli-responsive mesoporous silica nanoparticles (MSN) were developed and exploited in polymer coatings as multifunctional carriers of a typical corrosion inhibitor, benzotriazole (BTA). In detail, a new capping system based on a BTA/silver coordination complex, able to dissolve in acid and alkaline conditions and to simultaneously tailor the BTA release and the capture of chloride ions, was properly designed and realized. Acrylic coatings embedding the engineered MSN were deposited onto iron rebar samples and tested for their protective capability in acid and alkali

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Noor, Ahmed K. "The World is More Than Complicated." Mechanical Engineering 133, no. 11 (2011): 30–35. http://dx.doi.org/10.1115/1.2011-nov-1.

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This article discusses the need of complex systems to be adaptive, and various innovative technologies that are required to engineer these systems. Complex adaptive systems consist of several simultaneously interacting parts or components, which are expected to function in an uncertain, complex environment, and to adapt to unforeseeable contingencies. The defining characteristics of complex adaptive systems are that the components are continually changing, the systems involve many interactions among components, and configurations cannot be fully determined in advance. Studies have shown that c

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Kulkarni, Amol, Janis Terpenny, and Vittaldas Prabhu. "Sensor Selection Framework for Designing Fault Diagnostics System." Sensors 21, no. 19 (2021): 6470. http://dx.doi.org/10.3390/s21196470.

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In a world of rapidly changing technologies, reliance on complex engineered systems has become substantial. Interactions associated with such systems as well as associated manufacturing processes also continue to evolve and grow in complexity. Consider how the complexity of manufacturing processes makes engineered systems vulnerable to cascading and escalating failures; truly a highly complex and evolving system of systems. Maintaining quality and reliability requires considerations during product development, manufacturing processes, and more. Monitoring the health of the complex system while

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Sitterle, Valerie B., Erika L. Brimhall, Dane F. Freeman, Santiago Balestrini‐Robinson, Tommer R. Ender, and Simon R. Goerger. "Bringing Operational Perspectives into the Analysis of Engineered Resilient Systems." INSIGHT 28, no. 1 (2025): 30–38. https://doi.org/10.1002/inst.12524.

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ABSTRACTEngineered Resilient Systems (ERS) is a Department of Defense (DoD) program focusing on the effective and efficient design and development of complex engineered systems across their lifecycle. An important area of focus is the evaluation of early‐stage design alternatives in terms of their modeled operational performance and characteristics. The work in this paper ties together differentiated operational needs with requirements specification and maturation of previous analytical constructs toward a more operationally relevant viewpoint. We expand on the concept of Broad Utility as a hi

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Nossa, Roberta, Joana Costa, Ludovica Cacopardo, and Arti Ahluwalia. "Breathing in vitro: Designs and applications of engineered lung models." Journal of Tissue Engineering 12 (January 2021): 204173142110086. http://dx.doi.org/10.1177/20417314211008696.

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The aim of this review is to provide a systematic design guideline to users, particularly engineers interested in developing and deploying lung models, and biologists seeking to identify a suitable platform for conducting in vitro experiments involving pulmonary cells or tissues. We first discuss the state of the art on lung in vitro models, describing the most simplistic and traditional ones. Then, we analyze in further detail the more complex dynamic engineered systems that either provide mechanical cues, or allow for more predictive exposure studies, or in some cases even both. This is foll

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Li, Zhengwei, William C. Balance, Md Saddam Hossain Joy, et al. "Adaptive biohybrid pumping machine with flow loop feedback." Biofabrication 14, no. 2 (2022): 025009. http://dx.doi.org/10.1088/1758-5090/ac4d19.

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Abstract Tissue-engineered living machines is an emerging discipline that employs complex interactions between living cells and engineered scaffolds to self-assemble biohybrid systems for diverse scientific research and technological applications. Here, we report an adaptive, autonomous biohybrid pumping machine with flow loop feedback powered by engineered living muscles. The tissue is made from skeletal muscle cells (C2C12) and collagen I/Matrigel matrix, which self-assembles into a ring that compresses a soft hydrogel tube connected at both ends to a rigid fluidic platform. The muscle ring

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Rosa Sanabria, R., P. Eguia López, I. Aranzabal Santamaría, and I. Zamora Belver. "Model Based Systems Engineering Concepts and Methodologies for Modeling of Renewable Power Plants." Renewable Energy and Power Quality Journal 21, no. 1 (2023): 85–90. http://dx.doi.org/10.24084/repqj21.229.

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Model-Based Systems Engineering (MBSE) is the formal application of a model-centered methodology for the design activities of engineered systems, being especially useful to support design requirements verification and validation of complex systems. The complexity of a system can be measured according to the number and relationships of the system elements. The design of renewable power plants has grown in complexity in last few decades, due to the integration of new technologies and the application of grid-code requirements. In this paper, a review of MBSE main concepts and leading methodologie

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Han, Shuo, Boxuan Simen Zhao, Samuel A. Myers, Steven A. Carr, Chuan He, and Alice Y. Ting. "RNA–protein interaction mapping via MS2- or Cas13-based APEX targeting." Proceedings of the National Academy of Sciences 117, no. 36 (2020): 22068–79. http://dx.doi.org/10.1073/pnas.2006617117.

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RNA–protein interactions underlie a wide range of cellular processes. Improved methods are needed to systematically map RNA–protein interactions in living cells in an unbiased manner. We used two approaches to target the engineered peroxidase APEX2 to specific cellular RNAs for RNA-centered proximity biotinylation of protein interaction partners. Both an MS2-MCP system and an engineered CRISPR-Cas13 system were used to deliver APEX2 to the human telomerase RNA hTR with high specificity. One-minute proximity biotinylation captured candidate binding partners for hTR, including more than a dozen

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Jabeur, Nafaâ, Nabil Sahli, and Sherali Zeadally. "Enabling Cyber Physical Systems with Wireless Sensor Networking Technologies, Multiagent System Paradigm, and Natural Ecosystems." Mobile Information Systems 2015 (2015): 1–15. http://dx.doi.org/10.1155/2015/908315.

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Wireless sensor networks (WSNs) are key components in the emergent cyber physical systems (CPSs). They may include hundreds of spatially distributed sensors which interact to solve complex tasks going beyond their individual capabilities. Due to the limited capabilities of sensors, sensor actions cannot meet CPS requirements while controlling and coordinating the operations of physical and engineered systems. To overcome these constraints, we explore the ecosystem metaphor for WSNs with the aim of taking advantage of the efficient adaptation behavior and communication mechanisms of living orga

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Forsythe, Chris, and Caren Wenner. "Surety of Human Elements of High Consequence Systems: An Organic Model." Proceedings of the Human Factors and Ergonomics Society Annual Meeting 44, no. 22 (2000): 839–42. http://dx.doi.org/10.1177/154193120004402289.

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Despite extensive safety analysis and application of safety measures, there is a frequent lament, “Why do we continue to have accidents?” Two breakdowns are prevalent in risk management and prevention. First, accidents result from human actions that engineers, analysts and management never envisioned and second, controls, intended to preclude/mitigate accident sequences, prove inadequate. This paper addresses the first breakdown, the inability to anticipate scenarios involving human action/inaction. The failure of controls has been addressed in a previous publication (Forsythe and Grose, 1998)

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Luo, Jiren, Jiangfeng Chen, Yaoge Huang, Lingchong You, and Zhuojun Dai. "Engineering living materials by synthetic biology." Biophysics Reviews 4, no. 1 (2023): 011305. http://dx.doi.org/10.1063/5.0115645.

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Natural biological materials are programmed by genetic information and able to self-organize, respond to environmental stimulus, and couple with inorganic matter. Inspired by the natural system and to mimic their complex and delicate fabrication process and functions, the field of engineered living materials emerges at the interface of synthetic biology and materials science. Here, we review the recent efforts and discuss the challenges and future opportunities.

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Yan, Guangbo, Xia Li, Jun Yang, et al. "Cost-Effective Production of ATP and S-Adenosylmethionine Using Engineered Multidomain Scaffold Proteins." Biomolecules 11, no. 11 (2021): 1706. http://dx.doi.org/10.3390/biom11111706.

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Adenosine triphosphate (ATP) and S-adenosyl-L-methionine (SAM) are important intermediates that are widely present in living organisms. Large-scale preparation and application of ATP or SAM is limited by expensive raw materials. To lower the production costs for ATP/SAM, in this study we used strategies applying engineered multidomain scaffold proteins to synthesize ATP and SAM. An artificial scaffold protein containing CBM3 domain, IM proteins and CL-labeled proteins was assembled to form complex 1 for catalytic reactions to increase ATP production. The ATP synthesis system produced approxima

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Nandhini. "A STUDY ON TRIMODALDEPENDENCY GRAPH FORSOFTWARE CLUSTERING." IJCSET 2, no. 1 (2016): 10–17. https://doi.org/10.9091/zenodo.5574889.

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<strong>ABSTRACT</strong>- Software clustering is the process of combining multiple systems or applications into a cluster that act as a single system. The subsystems are reverse engineered to extract design data. When large software systems are reverse-engineered there is the possibility of the system decomposition hierarchy. Bunch’s software clustering tool shows how meta-heuristic search algorithms can be applied to the software clustering problem, successfully. But some uncertainty prevails whether Bunch provide the optimal solution. The optimal solution for trivi

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Obed, Doha, Nadjib Dastagir, Christina Liebsch, et al. "In Vitro Differentiation of Myoblast Cell Lines on Spider Silk Scaffolds in a Rotating Bioreactor for Vascular Tissue Engineering." Journal of Personalized Medicine 12, no. 12 (2022): 1986. http://dx.doi.org/10.3390/jpm12121986.

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Functional construction of tissue-engineered vessels as an alternative to autologous vascular grafts has been shown to be feasible, however the proliferation of seeded smooth-muscle cells remains a limiting factor. We employed a rotating bioreactor system to improve myoblast cell differentiation on a spider silk scaffold for tissue-engineered vessel construction. C2C12 myofibroblast cells were seeded on the surface of spider silk scaffold constructs and cultivated in a rotating bioreactor system with a continuous rotation speed (1 rpm). Cell function, cell growth and morphological structure an

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Ye, Yangyang, Qian Shi, Ting Yang, et al. "In Vivo Visualized Tracking of Tumor-Derived Extracellular Vesicles Using CRISPR-Cas9 System." Technology in Cancer Research & Treatment 21 (January 2022): 153303382210853. http://dx.doi.org/10.1177/15330338221085370.

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Introduction: Tumor extracellular vesicles (EVs) and their relevance to various processes of tumor growth have been vigorously investigated over the past decade. However, obtaining direct evidence of spontaneous EV transfer in vivo remains challenging. In our previous study, a single-guide RNA (sgRNA): Cas9 ribonucleoprotein complex, which can efficiently delete target genes, was delivered into recipient cells using an engineered EV. Aim: Applying this newly discovered exosomal bio-cargo to track the uptake and distribution of tumor EVs. Methods: Tumor cells of interest were engineered to expr

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Пушкарев, В. А., О. Н. Мусина, С. В. Беленькая, et al. "A complex of biochemical properties of recombinant reindeer (Rangifer tarandus) chymosin with point amino acid substitution K53E." Food processing industry, no. 5 (April 25, 2023): 16–19. http://dx.doi.org/10.52653/ppi.2023.5.5.004.

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Традиционно наилучшим коагулянтом молока для сыроделия считался коровий сычужный фермент – препарат, получаемый из слизистой оболочки желудков телят-молокопоек. Основным компонентом сычужного фермента является аспартатная молокосвертывающая протеиназа химозин. Мировой дефицит натурального сычужного фермента, возникший в середине XX века, инициировал поиск его заменителей. Одним из вариантов решения данной проблемы стала разработка технологий получения генно-инженерных аналогов химозина. В настоящее время для промышленного получения сыров уже используются рекомбинантные химозины коровы и одного

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Yasar, Ozlem, and Binil Starly. "Fabrication of Lindenmayer System-Based Designed Engineered Scaffolds Using UV-Maskless Photolithography." MRS Advances 1, no. 11 (2016): 749–54. http://dx.doi.org/10.1557/adv.2016.223.

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ABSTRACTIn the field of tissue engineering, design and fabrication of precisely and spatially patterned, highly porous scaffolds/matrixes are required to guide overall shape of tissue growth and replacement. Although rapid prototyping fabrication techniques have been used to fabricate the scaffolds with desired design characteristics, controlling the interior architecture of the scaffolds has been a challenge due to Computer-aided Design (CAD) constrains. Moreover, thick engineered tissue scaffolds show inadequate success due to the limited diffusion of oxygen and nutrients to the interior par

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Carballosa, Alejandro, Ana I. Gomez-Varela, Carmen Bao-Varela, Maria Teresa Flores-Arias, and Alberto P. Muñuzuri. "Photosensitive Control and Network Synchronization of Chemical Oscillators." Entropy 26, no. 6 (2024): 475. http://dx.doi.org/10.3390/e26060475.

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The Belousov–Zhabotinsky (BZ) reaction has long been a paradigmatic system for studying chemical oscillations. Here, we experimentally studied the synchronization control within photochemically coupled star networks of BZ oscillators. Experiments were carried out in wells performed in soda-lime glass constructed using novel laser technologies. Utilizing the inherent oscillatory nature of the BZ reaction, we engineered a star network of oscillators interconnected through photochemical inhibitory coupling. Furthermore, the experimental setup presented here could be extrapolated to more complex n

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Kaplan, Jonathan. "Hydraulics, Cacao, and Complex Developments at Preclassic Chocolá, Guatemala: Evidence and Implications." Latin American Antiquity 19, no. 4 (2008): 399–413. http://dx.doi.org/10.1017/s1045663500004351.

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Investigations begun in 2003 and continued through 2005 at Chocolá, in Southwestern Guatemala, have determined the existence of an extensive Preclassic network of well-engineered subterranean canals. The hydraulics discovered at the site, as well as other findings, add to long-standing evidence of Preclassic developments in the site's immediate region. While I consider an impressive Preclassic hydraulic system proven for Chocolá, a similarly early industry of cacao—a high-water demand plant of pan-Mesoamerican importance and native to the region—is discussed here admittedly only as a plausible

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Ghonim, Ossama Yehia Gouda Ahmed, and Ahmad Mahamad Al-Yacouby. "Hydrodynamic Response Assessment of Floating Photovoltaic System Subjected to Environmental Loadings." Journal of Advanced Research Design 132, no. 1 (2025): 15–27. https://doi.org/10.37934/ard.132.1.1527.

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Floating Photovoltaic systems (FPVs) represent a novel integration of solar energy technology with aquatic environments, marking a pivotal advancement in renewable energy applications. This paper introduces a new design for the floating system, specifically engineered to optimize performance under hydrodynamic conditions. Despite the significant focus on the field, the complex hydrodynamics of FPVs, particularly their resilience against varying offshore conditions, remain inadequately explored. This study seeks to bridge this knowledge gap by using an Excel-based analytical model to investigat

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Youn, Byeng D., Chao Hu, and Pingfeng Wang. "Resilience-Driven System Design of Complex Engineered Systems." Journal of Mechanical Design 133, no. 10 (2011). http://dx.doi.org/10.1115/1.4004981.

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Most engineered systems are designed with a passive and fixed design capacity and, therefore, may become unreliable in the presence of adverse events. Currently, most engineered systems are designed with system redundancies to ensure required system reliability under adverse events. However, a high level of system redundancy increases a system’s life-cycle cost (LCC). Recently, proactive maintenance decisions have been enabled through the development of prognostics and health management (PHM) methods that detect, diagnose, and predict the effects of adverse events. Capitalizing on PHM technolo

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Li, Minghua, Xing Pan, Naimin Zhang, Pengwei Hu, and Yuheng Dang. "Reliability of system-of-systems: A new challenge of complex engineered systems." Frontiers of Engineering Management, April 22, 2025. https://doi.org/10.1007/s42524-025-4244-6.

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Meluso, John, and Jesse Austin-Breneman. "Gaming the System: An Agent-Based Model of Estimation Strategies and their Effects on System Performance." Journal of Mechanical Design 140, no. 12 (2018). http://dx.doi.org/10.1115/1.4039494.

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Parameter estimates in large-scale complex engineered systems (LaCES) affect system evolution, yet can be difficult and expensive to test. Systems engineering uses analytical methods to reduce uncertainty, but a growing body of work from other disciplines indicates that cognitive heuristics also affect decision-making. Results from interviews with expert aerospace practitioners suggest that engineers bias estimation strategies. Practitioners reaffirmed known system features and posited that engineers may bias estimation methods as a negotiation and resource conservation strategy. Specifically,

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