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Thematische Bibliographien / COX-2 selective inhibitor / Dissertationen

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Dissertationen zum Thema „COX-2 selective inhibitor“

Autor: Grafiati

Veröffentlicht am 7. Juni 2025

Zuletzt aktualisiert am 2. August 2025

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1

Davies, Richard. "Effect of selective COX-2 inhibitors on hepatic progenitor cells and the pathologies of experimental hepatocarcinogenesis." University of Western Australia. School of Medicine and Pharmacology, 2007. http://theses.library.uwa.edu.au/adt-WU2007.0190.

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[Truncated abstract] Hepatocellular carcinoma (HCC) is the major malignancy complicating chronic liver disease. New therapies for the prevention of HCC are required due to the limited success and high tumour recurrence rates of existing treatments. Emerging evidence suggests that HCC arise from the transformation of adult liver progenitor cells (LPCs), which have the capacity to differentiate into hepatocytes and biliary cells during liver regeneration. LPC activation precedes neoplasia in experimental hepatocarcinogenesis. LPCs share antigenic epitopes with HCCs, including α-fetoprotein (AFP)

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Li, Zhigang. "Suppression of N-nitrosomethylbenzylamine(NMBA)-induced esophageal tumorigenesis in F344 rats by JTE-522,a selective COX-2 inhibitor." Kyoto University, 2002. http://hdl.handle.net/2433/149320.

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3

Silva, Aline Alves da. "Avaliação clínica de Rattus norvegicus após terapia antiinflamatória com inibidor seletivo ou não para COX-2 por extrapolação alométrica." Universidade Federal de Santa Maria, 2004. http://repositorio.ufsm.br/handle/1/4112.

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The anti-inflammatories no esteroidais (AINEs) they are the drugs of larger prescription all over the world, for humans and for animals. They combat the inflammation, the pain, the temperature increase, could also inhibit the aggregation plaques. They act inhibiting the production of the acid araquidônico and ciclooxigenases (COXs) decreasing like this, the prostaglandins production. They become separated in inhibitors no selective for COX-1 and 2, being those the most traditional; and in selective inhibitors for COX-2, considered more modern drugs. AINEs no selective they reduce the productio

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4

King, Liam Denson. "COX-2 selective inhibitors as an adjunct to radiotherapy." Thesis, Griffith University, 2018. http://hdl.handle.net/10072/382714.

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Background Radiotherapy is a common treatment modality for many solid state cancers including prostate cancer (PCa). Unfortunately, up to 50% of patients that undergo radiotherapy for localised PCa will develop biochemical failure. Acute and delayed toxicities and tumour resistance are two key factors limiting the effectiveness of many cancer treatments, including radiotherapy. Toxicity rates in PCa patients that accompany radiotherapy are high with 80% of men experiencing some degree of urinary frequency, 40% bowel frequency and chronic impotence is usual. Furthermore, tumour radioresistance

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5

Hasan, Kamrul. "Clclo-oxygenase (COX) isoforms in the cardiovascular system : Implications for the future of COX-2 selective inhibitors." Thesis, Imperial College London, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.536024.

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6

Chen, Qilei. "Discovery of COX-2 selective inhibitors from saussurea laniceps using an enzyme-anchored nanomagnetic ligand fishing platform." HKBU Institutional Repository, 2020. https://repository.hkbu.edu.hk/etd_oa/708.

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Serious cardiovascular side effects are reported from synthetic cyclooxygenase-2 (COX-2) selective nonsteroidal anti-inflammatory drugs, the most common medication for rheumatoid arthritis (RA) and osteoarthritis (OA). Natural products from herbal medicine are inspirational source of safe and effective remedy due to its distinguished chemical diversity. Nanomagnetic ligand fishing using enzyme-anchored-magnetic nanoparticles (MNPs) is an advanced selective bioseparation strategy based on macromolecular target-ligand binding, which can screen enzyme inhibitors from complex mixtures. "Snow lotus

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Gu, Baoying. "Selective increase of neuronal cyclooxygenase-2 (COX-2) expression in vulnerable brain regions of rats with experimental Wernicke's encephalopathy : effects of nimesulide." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112627.

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Wernicke's encephalopathy is a neuropsychiatric disorder resulting from thiamine deficiency (TD) and is characterized by neuronal loss, astrocytic proliferation and microglial activation. Cyclooxygenases (COX) are enzymes which catalyze the first step in the synthesis of prostanoids. COX-1 is expressed constitutively and COX-2 is the inducible isoform. Groups of TD rats and pair-fed controls were killed at presymptomatic and symptomatic stages of encephalopathy. Cresyl violet and NeuN staining showed decreased numbers of neuronal cells in vulnerable regions (medial thalamus and inferior collic

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8

Sawdy, Robert John. "The role of the type-2 isoform of the cyclooxygenase enzyme (COX-2) in human parturition : potential benefits of selective COX-2 inhibitors in the management of preterm labour." Thesis, Imperial College London, 2003. http://hdl.handle.net/10044/1/11444.

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9

Borges, Alexandre [UNESP]. "Estudos de modelagem molecular de lignanas em complexos com ciclooxigenases-1 e 2." Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/140137.

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Submitted by ALEXANDRE BORGES null (alex.brgs@hotmail.com) on 2016-06-28T19:11:21Z No. of bitstreams: 1 ESTUDOS DE MODELAGEM MOLECULAR DE LIGNANAS EM COMPLEXOS COM CICLOOXIGENASES-1 E 2.pdf: 4325586 bytes, checksum: 2f6ab56677aea7746bd28dad4b24ea23 (MD5)<br>Approved for entry into archive by Ana Paula Grisoto (grisotoana@reitoria.unesp.br) on 2016-06-29T17:41:12Z (GMT) No. of bitstreams: 1 borges_a_dr_ilha.pdf: 4325586 bytes, checksum: 2f6ab56677aea7746bd28dad4b24ea23 (MD5)<br>Made available in DSpace on 2016-06-29T17:41:12Z (GMT). No. of bitstreams: 1 borges_a_dr_ilha.pdf: 4325586 bytes,

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Borges, Alexandre. "Estudos de modelagem molecular de lignanas em complexos com ciclooxigenases-1 e 2 /." Ilha Solteira, 2016. http://hdl.handle.net/11449/140137.

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Orientador: Rosangela da Silva de Laurentiz<br>Resumo: Os inibidores seletivos da ciclooxigenase-2 (COX-2), como o rofecoxibe (2) e o celecoxibe (1), formam uma importante classe de medicamentos anti-inflamatórios desenvolvidos a partir da descoberta das duas isoformas das ciclooxigenases (COX-1 e COX-2) na década de 1979. A isoforma 1 esta relacionada com a citoproteção gástrica, agregação plaquetária e função renal e a isoforma 2 relacionada a processos inflamatórios. Estes inibidores seletivos apesar de não apresentarem os efeitos colaterais (ulceras e gastrites) dos anti-inflamatórios não

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Casanova, Rigat Isolda. "Mecanismes de transducció de senyal implicats en l'efecte dels inhibidors selectius de COX-2 en el tractament del càncer de còlon." Doctoral thesis, Universitat de Barcelona, 2004. http://hdl.handle.net/10803/1858.

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Els antiinflamatoris no esteroidals (AINEs) són fàrmacs que actuen inhibint l'activitat de les dues issoformes de l'enzim ciclooxigenassa (COX-1 i COX-2) i s'utilitzen principalment en clínica pel tractament del dolor i la inflamació, tot i que també s'ha descrit el seu ús com a antitumorals. El principal inconvenient d'aquests compostos és que el seu ús regular causa efectes secundaris, en gran part com a conseqüència de la inhibició de COX-1. Per a resoldre aquest problema, s'han desenvolupat compostos que inhibeixen específicament COX-2 de manera que, mantenint els efectes terapèutics conse

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12

Gunter, Bryan R., Kristen A. Butler, Rick L. Wallace, Steven M. Smith, and Sam Harirforoosh. "NSAIDs-Induced Cardio- and Cerebro-Vascular Adverse Events: a Meta-analysis." Digital Commons @ East Tennessee State University, 2017. https://doi.org/10.1111/jcpt.12484.

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What is known and objective: Although non-steroidal anti-inflammatory drugs (NSAIDs) have been studied in randomized, controlled trials and meta-analyses in an effort to determine their cardiovascular (CV) risks, no consensus has been reached. These studies continue to raise questions, including whether cyclooxygenase-2 (COX-2) selectivity plays a role in conferring CV risk. We performed a meta-analysis of current literature to determine whether COX-2 selectivity leads to an increased CV risk. Methods: We utilized randomized, controlled trials and prospective cohort studies. We selected eight

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13

Lin, Han-Wei, and 林涵威. "COX-2 Selective Inhibitor as a Chemoprevention Drug in Oral Potentially Malignant Disorder." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/93647722096428593991.

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碩士<br>國立臺灣大學<br>臨床牙醫學研究所<br>98<br>In Taiwan, especially due to the habit of betel quid chewing, the annual incidence of oral cancer is more than 4,000 cases. This disease combines with severe morbidity, which results in the 5-year survival rate is about 55% only. Oral cancer is frequently preceded by multifocal oral potentially malignant disorders (PMD) during multistep carcinogenesis, but there is still no better approach proved to be able to attenuate the occurring of oral cancer by the turnover of oral PMD. Cyclooxygenase-2 (COX-2) is induced by many factors including inflammatory stim

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14

Ou, Hui-Ling, and 歐蕙綾. "Novel effects of COX-2-selective inhibitor NS-398 on IL-1b-induced COX-2 and IL-8 expression in human ovarian granulosa cells." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/6yr899.

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碩士<br>國立陽明大學<br>生理學研究所<br>97<br>The process of ovulation is the key event for reproduction and therefore should be well-regulated. Ovarian hyperstimulation syndrome (OHSS), which results from excess production of some factors during ovulation, has been recognized as a dramatic complication of gonodotrophin therapy. Since ovulation has been proposed to be associated with inflammatory responses, inflammatory factors may be implicated in the occurrence of OHSS. In addition, ovarian granulosa cell tumor (GCT) is most commonly found in women between peri- and post-menopausal ages; therefore a hypot

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15

"The effect of a selective COX-2 inhibitor, celecoxib, on the proliferation, apoptosis and differential protein expression in nasopharyngeal carcinoma cell lines." Thesis, 2008. http://library.cuhk.edu.hk/record=b6074609.

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Celecoxib is a COX-2 selective non-steroidal anti-inflammatory drug which has been shown to inhibit growth and induce apoptosis in various cancer cell lines. Using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and an apoptosis detection kit, we demonstrated that celecoxib was able to induce growth inhibition and apoptosis in a dose-dependent manner in 3 NPC cell lines: HK-1, Hone-1, and C666-1. Afterwards, a proteomic approach was used to study the underlying mechanisms involved in celecoxib-mediated effects on two COX-2 positive NPC cell lines (HK-1 and C666-1). Results s

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16

Ting-Ni, Wu, and 吳庭妮. "Direct and indirect suppressive effects of selective COX-2 inhibitor on adipose inflammation in high fat-induced and db/db obese mice." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/22908277848134076358.

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碩士<br>國防醫學院<br>生理學研究所<br>98<br>Our previous studies suggested that COX-2 activation in obese adipose tissue plays a crucial role in the development of insulin resistance and fatty liver in high-fat-fed rats. The aim of this study was to further clarify the direct and indirect body-weight-reducing effects of COX-2 inhibition on obesity-induced adipose inflammation in high fat-fed and db/db mice. The mice were fed regular diet (CONT) or high-fat diet ad libitum (HFa), co-treated with vehicle or selective COX2 inhibitor-celecoxib (CONT-Cel) or (HFa-Cel) for 16 weeks. HFa-Cel group was further div

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17

"The impact of selective COX-2 inhibitor on the cost of NSAID-induced gastrointestinal toxicity in a public hospital setting in Hong Kong." 2005. http://library.cuhk.edu.hk/record=b5892477.

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Ho Toi Sze Joyce.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2005.<br>Includes bibliographical references (leaves 65-74).<br>Abstracts in English and Chinese.<br>Acknowledgement --- p.ii<br>Contents --- p.iii<br>Abstract --- p.viii<br>List of Abbreviations --- p.xvii<br>List of Tables --- p.xix<br>List of Figures --- p.xx<br>Chapter Chapter 1 --- Introduction --- p.1<br>Chapter 1.1 --- The role of Non-steroidal anti-inflammatory drugs (NSAIDs) --- p.1<br>Chapter 1.2 --- NSAID-induced gastrointestinal (GI) toxicity --- p.1<br>Chapter 1.2.1 --- Pathogenesis of NSAID-induced G

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18

Hétu, Pierre-Olivier. "Rôle de la cyclo-oxygénase-2 constitutive dans la synthèse des prostaglandines et caractérisation de ses relations avec les prostaglandines synthases terminales." Thèse, 2008. http://hdl.handle.net/1866/6587.

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19

Subhashini, J. "C-Phycocyanin and celecoxib, selective COX-2 inhibitors, induce apoptosis in chronic myeioid leukemia cell line - K562." Thesis, 2003. http://hdl.handle.net/2009/841.

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20

Chang, Kuei-wen, and 張桂文. "COX-2 Selective Inhibitors Prescribing in Primary Care---Considerations of Taiwan National Health Insurance Medication Coverage Management." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/c3qa6j.

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碩士<br>嘉南藥理科技大學<br>醫療資訊管理研究所<br>97<br>Objectives: In order to decrease improper COX-2 selective (COX-2) inhibitors prescribing, the portions of COX-2 inhibitors prescriptions in violation of the medications rules adopted by Taiwan National Health Insurance exceeding the recommended rate are not eligible for reimbursement in October 2006. The aim of this study was to explore the effects of this medication management and examine the factors influencing whether COX-2 inhibitors prescription following medications rules. Methods: We selected COX-2 prescriptions from the NHI outpatient database durin

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