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Thematische Bibliographien / Cqb / Zeitschriftenartikel

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Zeitschriftenartikel zum Thema „Cqb“

Autor: Grafiati

Veröffentlicht am 24. Juni 2021

Zuletzt aktualisiert am 29. Juli 2025

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1

Missa, Hildegardis, Olegario De Fatima Lelo Carion, Yolenta Sisilia Enggong, Aloysius Djalo, and Sardina Ndukang. "Isolations andAntibacterial Tests of Aloe Vera Endophytic Bacteria (Aloe barbadensis miller) towards Staphylococcus aureus and Eschericia coli." Agro Bali : Agricultural Journal 6, no. 1 (2023): 47–55. http://dx.doi.org/10.37637/ab.v6i1.964.

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Research in the field of microbiology regarding the identification of endophytic bacteria in aloe vera is still rarely carried out while many people in East Nusa Tenggara often use aloe vera to cure diseases. The purpose of this study was to identify the endophytic bacteria Aloe barbadensis miller and to determine its antibacterial ability against the growth of Staphylococcus aureus and Escsherichia coli bacteria. The research procedures included taking samples using purposive sampling method, isolating endophytic bacteria using streak plate method, testing the antibacterial potential against

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Effting, Cristiane, Fernando Gomes Ferreira Oliveira, Iram Moreira Mundim, et al. "Otimização de método analítico em HPLC-PDA para monitoração terapêutica do bussulfano oral em pacientes transplantados de células-tronco hematopoiéticas." Research, Society and Development 10, no. 6 (2021): e48110615864. http://dx.doi.org/10.33448/rsd-v10i6.15864.

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Otimizou-se método para monitoração plasmática de bussulfano em pacientes submetidos a transplante de células-tronco hematopoiéticas (TCTH). Utilizou-se HPLC-PDA Shimadzu, coluna C18 (150 mm x 4 mm), metanol/água/acetonitrila (65:20:15, v/v/v), fluxo 1 mL min-1; UV λ = 276 nm, tempo de análise de 17 min; derivatização com dietilcarbamato de sódio, extração com acetato de etila; curva de calibração linear de 200-5000 ng mL-1. A recuperação relativa dos controles foi de 89%±0,04 (CQA = 86%; CQM = 87%; CQB = 93%) e a do PI (padrão interno) foi de 74%±0,47. A recuperação absoluta dos controles foi

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Elf, Marie, Maria Svedbo Engström, and Helle Wijk. "Development of the Content and Quality in Briefs Instrument (CQB-I)." HERD: Health Environments Research & Design Journal 5, no. 3 (2012): 74–88. http://dx.doi.org/10.1177/193758671200500308.

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Objective: The Content and Quality in Briefs Instrument (CQB-I) was designed to develop a valid and reliable audit instrument to examine the content and quality of information in documents (briefs) created in the early stages of designing healthcare environments. Background: The importance of effective briefing has been emphasized in many research studies during the past two decades. However, there is no developed instrument for auditing the content and quality of these documents. Methods: The study had a methodological and developmental design based on an established methodology for instrumen

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Markel, Russell W., and Jonathan B. Shurin. "Contrasting effects of coastal upwelling on growth and recruitment of nearshore Pacific rockfishes (genus Sebastes)." Canadian Journal of Fisheries and Aquatic Sciences 77, no. 6 (2020): 950–62. http://dx.doi.org/10.1139/cjfas-2019-0179.

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Knowledge of processes underlying recruitment is critical for understanding marine population dynamics and their response to ocean climate. We investigated the relationship between coastal upwelling and early life history of black rockfish (Sebastes melanops), a midwater aggregating species, and CQB rockfishes (a solitary benthic species complex including Sebastes caurinus, Sebastes maliger, and Sebastes auriculatus), between two oceanographically distinct years on the west coast of Vancouver Island, Canada. We analysed otolith microstructure to determine parturition and settlement dates, pela

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Baldwin, Michael. "Christopher Butterfield - CHRISTOPHER BUTTERFIELD: Trip. Quatuor Bozzini. Collection QB. CQB 1719." Tempo 72, no. 285 (2018): 96–98. http://dx.doi.org/10.1017/s0040298218000207.

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Mantua, Janna, Joseph D. Shevchik, Sidhartha Chaudhury, Hannah P. Eldringhoff, Carolyn A. Mickelson, and Ashlee B. McKeon. "Sleep and Infantry Battle Drill Performance in Special Operations Soldiers." Aerospace Medicine and Human Performance 93, no. 7 (2022): 557–61. http://dx.doi.org/10.3357/amhp.6040.2022.

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BACKGROUND: Although multiple studies have documented the impact of insufficient sleep on soldier performance, most studies have done so using artificial measures of performance (e.g., tablet or simulator tests). The current study sought to test the relationship between sleep and soldier performance during infantry battle drill training, a more naturalistic measure of performance.METHODS: Subjects in the study were 15 junior Special Operations infantry soldiers. Soldiers wore an actigraph and reported their subjective sleep duration and quality prior to close quarter battle (CQB) drills. Exper

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Potter, Caroline. "Eliane Radigue - Eliane Radigue, Occam Delta XV. Quatuor Bozzini. Collection QB, CQB 2331." Tempo 77, no. 306 (2023): 127–28. http://dx.doi.org/10.1017/s0040298223000451.

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Galih, Muhammad Iqbal, Budi Harijanto, and Jeki Saputra. "SISTEM KENDALI DAN TELEMETRI DARI ROBOT CQB MK1 (CLOSE QUARTER BATTLE) KE BASE STATION MENGGUNAKAN FREQUENCY 5.8 GHz." Jurnal Elkasista 2, Mei (2021): 10–21. http://dx.doi.org/10.54317/elka.v2imei.150.

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Perkembangan teknologi di dalam dunia elektronika khususnya robotika berkembang dengan sangat pesat. Kebutuhan manusia akan alat bantu yang kuat, akurat dan efisien mendorong manusia terus melakukan penelitian untuk menghasilkan robot-robot yang dapat menggantikan tugas-tugas manusia di bidang militer supaya mengurangi korban jiwa pada personil yang ditugaskan pada daerah-daerah rawan. Salah satu robot yang sedang dikembangkan dalam penelitian adalah robot CQB (Close Quarter Battle) MK1. Pada penelitian ini, peneliti merancang sebuah sistem kendali dan telemetri yang dipergunakan untuk menghub

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Watanabe, Jota, and Juan C. Scornik. "Measuring Human Complement Activation by HLA Antibodies." Archives of Pathology & Laboratory Medicine 130, no. 3 (2006): 368–73. http://dx.doi.org/10.5858/2006-130-368-mhcabh.

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Abstract Context.—The clinical significance of HLA antibodies in transplantation depends on their ability to activate complement, which is measured by the standard complement-dependent cytotoxicity test. Recent reports indicate that C3b measurement on target cells may be a better indicator of human complement activation than standard cytotoxicity. Objective.—To determine the characteristics of the test, the role of other complement components, and the potential influence of the patient's own complement activity. Design.—The T-cell deposition of multiple complement components triggered by HLA a

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Zhang, Lin, Lei Tong, Pengguang Zhu, et al. "Adsorption of chlortetracycline onto biochar derived from corn cob and sugarcane bagasse." Water Science and Technology 78, no. 6 (2018): 1336–47. http://dx.doi.org/10.2166/wst.2018.407.

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Abstract Biochar was prepared from two different types of biological waste materials, corn cob (CC) and sugarcane bagasse (SB). The adsorption capacity of each class of adsorbent was determined by chlortetracycline (CTC) adsorption tests. The adsorption kinetics and isotherms of chlortetracycline onto sugarcane bagasse biochar (SBB) and corn cob biochar (CCB) were studied. Experimental results indicated that pseudo-second-order adsorption kinetics of CTC onto SBB and CCB were more reasonable than pseudo-first-order kinetics, and the adsorption kinetic model of CTC onto SBB was slightly better

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Bulfa, Arsenio, Gina Villegas-Pangga, and Amparo Wagan. "Corn Cob and Corn Husk Biochars Enhance the Growth of Corn (Zea mays L.) in Fertilized Clay Loam Soil." Philippine Agricultural Scientist 106, no. 2 (2023): 103–15. http://dx.doi.org/10.62550/dc042022.

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Biochar is a carbon (C) rich material that improves soil quality, increases crop yield, and is produced from biomass pyrolysis under a limited oxygen environment. An experiment laid out in a split-plot, a completely randomized design (CRD) and was conducted to investigate the growth responses of corn-to-corn cob biochar (CCB) (15 t ha-1), and corn husk biochar (CHB) (15 t ha-1) in a Lipa clay loam soil (Typic Eutrudepts) applied with organic fertilizer (OF) (10 t ha-1) and inorganic fertilizer [recommended rate (RR):120 N;60 P2O5-60; K2O per ha]. The results showed that CCB and CHB are rich in

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Fukai, Junya, Takahiro Sasaki, Toshikazu Yamoto, et al. "COT-1 Clinical Questions and Answers about Glioma-Related Epilepsy (GRE): Real-world data in Wakayama Medical University Hospital." Neuro-Oncology Advances 3, Supplement_6 (2021): vi28. http://dx.doi.org/10.1093/noajnl/vdab159.110.

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Abstract Introduction: In glioma patients, epilepsy not infrequently occurred and anti-epileptic drugs (AEDs) are commonly used. In this study, we revealed the real-world data on clinical practice of glioma-related epilepsy in Wakayama Medical University Hospital (WMUH). Methods. We collected clinical and molecular data of glioma patients operated at WMUH from January 1996 to December 2020 and analyzed the data to answer clinical questions as follows: 1) location/histology related GRE, 2) molecular features related GRE, 3) prophylactic AEDs and postoperative seizure, 4) tumor progression and c

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Pratama, Eko Wahyu, Mohammad Ansori, and Kusno Suryadi. "The SYSTEM IDENTIFICATION OF FRIEND AND ENEMY USING NIGHT VISION CAMERA ON BATTLE ROBOT (CQB) USING PATTERN RECOGNITION METHOD." Jurnal Elkasista 2, Oktober (2021): 15–23. http://dx.doi.org/10.54317/elka.v2ioktober.202.

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Abstract – Indonesian Army has the main task of protecting against enemy attacks, which include forest battles as well as urban battles. The obstacle faced today is that in the process of urban warfare operations, infiltration and hostage rescue in buildings are still less efficient and optimal. The robot is designed with a system that can identify friends and foes using a Night Vision camera and the Pattern Recognition method. Pattern recognition is a symbolic grouping automatically that is done by a computer to find out objects or patterns. The results of the Night vision camera test are abl

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COSTA JUNIOR, Gilberto Ferreira da, Derly Oliveira DA SILVA, and Wilsione José CARNEIRO. "DESENVOLVIMENTO E VALIDAÇÃO DE MÉTODO ANALÍTICO PARA DETERMINAR O DOSEAMENTO DE CINARIZINA EM CÁPSULAS MAGISTRAIS." PERIÓDICO TCHÊ QUÍMICA 20, no. 43 (2023): 1–11. http://dx.doi.org/10.52571/ptq.v20.n43.2023_01_carneiro_pgs_01_11.pdf.

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Background: Cinnarizine is a brain vasodilator used in labyrinth diseases, a disorder characterized by dizziness, gait deviations, or falling. The quality control of compounded capsules containing cinnarizine is limited. Because of the difficulty accessing official pharmacopeia monographs of this drug, there is a need to describe an analytical method that is reliable and safe to perform the quantitative determination of cinnarizine in capsules. Aim: This work aims to develop and validate an analytical method to determine cinnarizine assay in capsules by spectrophotometry in the UV region that

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Kusumah, Andrian Anggar, Petrus Gunawan Wibisono, and Suko Wiyanto. "The MODIFICATION OF CONTROLLING SYSTEM ON CQB MK1 (CLOSE QUARTER BATTLE) ROBOT BASED ON ARDUINO MEGA 2560 USING PID METHOD." Jurnal Elkasista 2, Oktober (2021): 60–69. http://dx.doi.org/10.54317/elka.v2ioktober.208.

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Abstract - PJD (close combat) in the Indonesian National Army is a battle conducted in the city and in a very large area. CQB (close quarter battle) robot is a robot to perform reconnaissance and paralyze opponents during close combat. The obstacles faced by the Indonesian National Army are city wars, wars in building areas and while conducting reconnaissance are still very lacking. From the above constraints, the author seeks to create a solution, namely by designing a mobile robot that is used to help soldiers during close combat and can use robots that are moved remotely using joysticks. In

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Zhou, Yang, Fengying Guan, Zhen Li, Yaxiong Zheng, Xiao Zhou, and Xuan Zhang. "Effects of Tree Species on Moso Bamboo (Phyllostachys edulis (Carriere) J. Houzeau) Fine Root Morphology, Biomass, and Soil Properties in Bamboo–Broadleaf Mixed Forests." Forests 13, no. 11 (2022): 1834. http://dx.doi.org/10.3390/f13111834.

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Understanding fine root characteristics in relation to soil properties of bamboo–broadleaf mixed forests may help optimize belowground production management and ecological functions in mixed-forest ecosystems. In this study, we compared four different bamboo–broadleaf mixed forests: Castanopsis chinensis (Sprengel) Hance with moso bamboo (CCB), Alniphyllum fortunei (Hemsl.) Makino with moso bamboo (AFB), Choerospondias axillaris (Roxb.) Burtt and Hill with moso bamboo (CAB), and Castanopsis fargesii Franch with moso bamboo (CFB), and analyzed their effects on the traits of fine roots of moso b

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Cooray, Asantha. "Extragalactic background light measurements and applications." Royal Society Open Science 3, no. 3 (2016): 150555. http://dx.doi.org/10.1098/rsos.150555.

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This review covers the measurements related to the extragalactic background light intensity from γ-rays to radio in the electromagnetic spectrum over 20 decades in wavelength. The cosmic microwave background (CMB) remains the best measured spectrum with an accuracy better than 1%. The measurements related to the cosmic optical background (COB), centred at 1 μm, are impacted by the large zodiacal light associated with interplanetary dust in the inner Solar System. The best measurements of COB come from an indirect technique involving γ-ray spectra of bright blazars with an absorption feature re

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Bentley, D. R. "Primary structure of human complement component C2 Homology to two unrelated protein families." Biochemical Journal 239, no. 2 (1986): 339–45. http://dx.doi.org/10.1042/bj2390339.

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The primary structure of the second component of human complement (C2) was determined by cDNA cloning and sequence analysis. C2 has 39% identity with the functionally analogous protein Factor B. The C-terminal half of C2a is homologous to the catalytic domains of other serine proteinases. C2b contains three direct repeats of approx. 60 amino acid residues. They are homologous to repeats in Factor B, C4b-binding protein and Factor H, suggesting a functional significance of the repeat in C4b and C3b binding. The repeats are also found in the non-complement proteins beta 2-glycoprotein I and inte

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Xu, Y., and J. E. Volanakis. "Contribution of the complement control protein modules of C2 in C4b binding assessed by analysis of C2/factor B chimeras." Journal of Immunology 158, no. 12 (1997): 5958–65. http://dx.doi.org/10.4049/jimmunol.158.12.5958.

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Abstract To identify the complement control protein (CCP) module(s) of C2 that are required for C4b recognition, we constructed a panel of C2/factor B chimeras by substituting intact or partial factor B CCP modules for the corresponding ones of C2. Epitope mapping indicated that the anti-C2b mAb 3A3.3, which inhibits binding of C2 to C4b, reacts with the second CCP of C2 and similarly the anti-Ba mAb HA4-1A, which inhibits binding of factor B to C3b, reacts with the second CCP of factor B. The hemolytic activity of the chimeras CP1, CP2, and CP3a containing CCP1, CCP2, and a fragment of CCP3 o

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Du, Xuefeng, ChenHan Jiang, Hang Xu, Gengwei Zhang, and Zhenguo Li. "How to Save your Annotation Cost for Panoptic Segmentation?" Proceedings of the AAAI Conference on Artificial Intelligence 35, no. 2 (2021): 1282–90. http://dx.doi.org/10.1609/aaai.v35i2.16216.

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How to properly reduce the annotation cost for panoptic segmentation? How to leverage and optimize the cost-quality trade-off for training data and model? These questions are key challenges towards a label-efficient and scalable panoptic segmentation system due to its expensive instance/semantic pixel-level annotation requirements. By closely examining different kinds of cheaper labels, we introduce a novel multi-objective framework to automatically determine the allocation of different annotations, so as to reach a better segmentation quality with a lower annotation cost. Specifically, we des

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Takata, Y., T. Kinoshita, H. Kozono, et al. "Covalent association of C3b with C4b within C5 convertase of the classical complement pathway." Journal of Experimental Medicine 165, no. 6 (1987): 1494–507. http://dx.doi.org/10.1084/jem.165.6.1494.

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The C5 convertase of the classical complement pathway is a complex enzyme consisting of three complement fragments, C4b, C2a, and C3b. Previous studies have elucidated functional roles of each subunit (4, 6, 7), but little is known about how the subunits associate with each other. In this investigation, we studied the nature of the classical C5 convertase that was assembled on sheep erythrocytes. We found that one of the nascent C3b molecules that had been generated by the C3 convertase directly bound covalently to C4b. C3b bound to the alpha' chain of C4b through an ester bond, which could be

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Janowska-Wieczorek, Anna, Leah A. Marquez-Curtis, Danila Leontyev, Donald R. Branch, Janina Ratajczak, and Mariusz Z. Ratajczak. "Studies in C4b-Deficient Mice Provide Further Evidence That Complement Cascade Orchestrates the Mobilization of Hematopoietic Stem/Progenitor Cells." Blood 120, no. 21 (2012): 2316. http://dx.doi.org/10.1182/blood.v120.21.2316.2316.

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Abstract Abstract 2316 Introduction: Complement cascade (CC) and innate immunity have emerged as important modulators of hematopoietic stem/progenitor cell (HSPC) trafficking. We reported that the CC becomes activated in bone marrow (BM) during HSPC mobilization induced by G-CSF or AMD3100 and proposed that the generation of C5a and C5b-C9 (membrane attack complex; MAC) is required for optimal mobilization (Stem Cells 2007; 25:3093; Leukemia 2010; 24:976). While C5a induces a proteolytic microenvironment in BM that attenuates SDF-1-CXCR4 retention signals for HSPC and promotes egress of leucoc

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Bernet, John, Jayati Mullick, Yogesh Panse, Pradeep B. Parab, and Arvind Sahu. "Kinetic Analysis of the Interactions between Vaccinia Virus Complement Control Protein and Human Complement Proteins C3b and C4b." Journal of Virology 78, no. 17 (2004): 9446–57. http://dx.doi.org/10.1128/jvi.78.17.9446-9457.2004.

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ABSTRACT The vaccinia virus complement control protein (VCP) is an immune evasion protein of vaccinia virus. Previously, VCP has been shown to bind and support inactivation of host complement proteins C3b and C4b and to protect the vaccinia virions from antibody-dependent complement-enhanced neutralization. However, the molecular mechanisms involved in the interaction of VCP with its target proteins C3b and C4b have not yet been elucidated. We have utilized surface plasmon resonance technology to study the interaction of VCP with C3b and C4b. We measured the kinetics of binding of the viral pr

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Haapasalo, Karita, Taru Meri, and T. Sakari Jokiranta. "Loa loa Microfilariae Evade Complement Attack In Vivo by Acquiring Regulatory Proteins from Host Plasma." Infection and Immunity 77, no. 9 (2009): 3886–93. http://dx.doi.org/10.1128/iai.01583-08.

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ABSTRACT Loa loa is a filarial nematode that infects humans. The adults live in subcutaneous tissues and produce microfilariae that live for several weeks in the blood circulation in order to be transmitted to another person via blood meals of a dipterian vector. As microfilariae live in continuous contact with plasma, it is obvious that they evade the complement system. We studied markers of complement activation and signs of complement regulation on Loa loa microfilariae in vivo. The microfilariae were isolated from anticoagulated blood samples of a Loa loa-infected Caucasian patient. C1q an

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Raghunathan, Srinivasan, and Yuuki Omori. "A Cross-internal Linear Combination Approach to Probe the Secondary CMB Anisotropies: Kinematic Sunyaev–Zel’dovich Effect and CMB Lensing." Astrophysical Journal 954, no. 1 (2023): 83. http://dx.doi.org/10.3847/1538-4357/ace0c6.

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Abstract We propose a cross-internal linear combination (cross-ILC) approach to measure the small-scale cosmic microwave background (CMB) anisotropies robustly against the contamination from astrophysical signals. In particular, we focus on the mitigation of systematics from cosmic infrared background (CIB) and thermal Sunyaev–Zel’dovich (tSZ) signals in kinematic Sunyaev–Zel’dovich (kSZ) power spectrum and CMB lensing. We show the cross-spectrum measurement between two CMB maps created by nulling the contributions from CIB (CIB-free map) and tSZ (tSZ-free map) to be robust for kSZ, as the app

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Kinoshita, T., A. W. Dodds, S. K. A. Law, and K. Inoue. "The low C5 convertase activity of the C4A6 allotype of human complement component C4." Biochemical Journal 261, no. 3 (1989): 743–48. http://dx.doi.org/10.1042/bj2610743.

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We have compared the C5-convertase-forming ability of different C4 allotypes, including the C4A6 allotype, which has low haemolytic activity and which has previously been shown to be defective in C5-convertase formation. Recent studies suggest that C4 plays two roles in the formation of the C5 convertase from the C3 convertase. Firstly, C4b acts as the binding site for C3 which, upon cleavage by C2, forms a covalent linkage with the C4b. Secondly, C4b with covalently attached C3b serves to form a high-affinity binding site for C5. Purified allotypes C4A3, C4B1 and C4A6 were used to compare the

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Pangburn, M. K. "Differences between the binding sites of the complement regulatory proteins DAF, CR1, and factor H on C3 convertases." Journal of Immunology 136, no. 6 (1986): 2216–21. http://dx.doi.org/10.4049/jimmunol.136.6.2216.

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Abstract Binding studies using purified decay-accelerating factor (DAF), CR1, and Factor H indicate that the primary interaction of DAF with C3 convertases is with the Bb or C2a subunits, whereas CR1 and Factor H interact primarily with the C3b or C4b subunits. The ability of soluble DAF, CR1, or Factor H to decay C3b,Bb bound to zymosan was inhibited by various concentrations of fluid-phase competitors (C3b, Bb, C3b,Bb, C3b,B, C4b, or C4b,C2a) in 0.1% NP-40 at 22 degrees C. The apparent association constants (appKa) for DAF were 0.045, 0.067, 0.91, 0.71, 0.00045, and 0.53 microM-1, respective

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Iacomino, Nicola, Fiammetta Vanoli, Rita Frangiamore, et al. "Complement Activation Profile in Myasthenia Gravis Patients: Perspectives for Tailoring Anti-Complement Therapy." Biomedicines 10, no. 6 (2022): 1360. http://dx.doi.org/10.3390/biomedicines10061360.

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The complement system plays a key role in myasthenia gravis (MG). Anti-complement drugs are emerging as effective therapies to treat anti-acetylcholine receptor (AChR) antibody-positive MG patients, though their usage is still limited by the high costs. Here, we searched for plasma complement proteins as indicators of complement activation status in AChR-MG patients, and potential biomarkers for tailoring anti-complement therapy in MG. Plasma was collected from AChR-MG and MuSK-MG patients, and healthy controls. Multiplex immunoassays and ELISA were used to quantify a panel of complement compo

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Huang, Travis K., Sheng-Wei Lin, Kuan-Yu Lin, and Yi-Ting Wang. "How Does Customer Online Behavior Influence Community Satisfaction?" Prosiding Seminar Nasional Forum Manajemen Indonesia - e-ISSN 3026-4499 2 (August 31, 2024): 932–44. http://dx.doi.org/10.47747/snfmi.v2i1.2078.

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This study examines the effects of user participation in brand communities on social networking sites. First, the concept of customer value cocreation behavior is introduced to observe user participation. Through the lens of customer value cocreation behavior, the study proposes two types of user participation, customer citizenship behavior (CCB) and customer participation behavior (CPB), which are operationalized as two second-order constructs in the study. In addition, two antecedents of CCB and CPB, namely, community identification and narcissism, are included in the research model with the

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Huang, Travis K., Sheng-Wei Lin, Kuan-Yu Lin, and Yi-Ting Wang. "How Does Customer Online Behavior Influence Community Satisfaction?" Proceedings of Forum Manajemen Indonesia's International Conferences, no. 1 (August 31, 2024): 932–44. https://doi.org/10.47747/fmiic.v1i1.2139.

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This study examines the effects of user participation in brand communities on social networking sites. First, the concept of customer value cocreation behavior is introduced to observe user participation. Through the lens of customer value cocreation behavior, the study proposes two types of user participation, customer citizenship behavior (CCB) and customer participation behavior (CPB), which are operationalized as two second-order constructs in the study. In addition, two antecedents of CCB and CPB, namely, community identification and narcissism, are included in the research model with the

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Subramanian, V. B., L. Clemenza, M. Krych, and J. P. Atkinson. "Substitution of two amino acids confers C3b binding to the C4b binding site of CR1 (CD35). Analysis based on ligand binding by chimpanzee erythrocyte complement receptor." Journal of Immunology 157, no. 3 (1996): 1242–47. http://dx.doi.org/10.4049/jimmunol.157.3.1242.

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Abstract The chimpanzee (Ch) E complement receptor type 1 (CR177) appears to be an alternatively spliced product of the Ch CR1 gene transcript. Its cDNA-derived amino acid sequence contains complement protein-repeating modules (CP) 1-6, 28, 29, and 30 in tandem and is 98.8% homologous to the corresponding regions of human (Hu) CR1. It differs from the C4b binding site of Hu CR1 only by two amino acids, Tyr for Ser37 in CP 1 and Asp for Gly79 in CP 2. However, in addition to binding C4b, Ch E binds C3b. As homologous substitution of one of these amino acids (Tyr for Ser37) was previously shown

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Kaidoh, T., and I. Gigli. "Phylogeny of C4b-C3b cleaving activity: similar fragmentation patterns of human C4b and C3b produced by lower animals." Journal of Immunology 139, no. 1 (1987): 194–201. http://dx.doi.org/10.4049/jimmunol.139.1.194.

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Abstract Functional and structural studies of the activated proteins of the complement system C4b and C3b have led to the identification of cleavage products resulting from the effect of the regulatory proteins, factor I, H, and C4b binding protein (bp). In this paper we report the results of studies that investigated the capacity of plasma or serum from a wide range of phylogenetic species to yield similar cleavage products. Sera and plasma from mammals, reptiles, amphibia, and fishes are capable of cleaving fluid phase human C4b and C3b, generating apparently the same fragments as observed u

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Walpoth, B. H., M. Nikles, P. J. Spaeth, U. E. Nydegger, and U. Althaus. "Evaluation of Complement Activation on Cardiopulmonary Bypass and in Retransfused Oxygenator and Shed Mediastinal Blood." Journal of ExtraCorporeal Technology 23, no. 3 (1991): 128–33. http://dx.doi.org/10.1051/ject/1991233128.

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Several methods of blood salvage are used in cardiac surgery. Our aim was to study, on the basis of complement activation, the quality of autologous blood products reinfused to the patient. Eleven patients with elective myocardial revascularisation were studied for: operative and cardiopulmonary bypass (CPB) data, hematology, blood chemistry and complement activation (C3a [des Arg] and terminal complement complex [TCC] or C5b-9 complex). Centrifugated oxygenator blood (COB) and shed mediastinal blood (SMB) samples were examined before reinfusion into the patient and the effect of this retransf

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Korak, Tuğcan, İbrahim Halil Baloğlu, Murat Kasap, Elif Damla Arisan, Gurler Akpinar, and Serdar Arisan. "Proteomic and In Silico Analyses Highlight Complement System’s Role in Bladder Cancer Immune Regulation." Medicina 61, no. 4 (2025): 735. https://doi.org/10.3390/medicina61040735.

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Background and Objectives: Bladder cancer (BLCA), intimately associated with the immune system, represents a substantial global health burden due to its high recurrence rates and limited therapeutic effectiveness. Although immunotherapy shows promise, challenges persist due to the lack of reliable therapeutic targets. This study aims to investigate potential immune-related biomarkers that could influence the tumor microenvironment in BLCA, using proteomic and in silico approaches. Materials and Methods: Tissue samples from BLCA patients (n = 27) and controls (n = 27) were collected from Şişli

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Kaidoh, T., and I. Gigli. "Phylogeny of regulatory proteins of the complement system. Isolation and characterization of a C4b/C3b inhibitor and a cofactor from sand bass plasma." Journal of Immunology 142, no. 5 (1989): 1605–13. http://dx.doi.org/10.4049/jimmunol.142.5.1605.

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Abstract We have previously demonstrated that the alpha'-chain of human activated form of the fourth (C4b) and third (C3b) component of C are cleaved by plasma or serum from vertebrate species spanning through 300,000,000 yr of evolution yielding fragments identical with those obtained with human plasma. In this study, we investigated the molecular basis of this reaction. We chose barred sand bass plasma because this is the most primitive species analyzed possessing these activities. Barred sand bass plasma proteins were separated on a Sephadex G-200 column and the eluted samples analyzed for

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Zhang, Menglu, Xuan Wang, Chen Yang, Miao Chen, Junling Zhuang, and Bing Han. "The Change of Complement Deposition after Complement Inhibitor Treatment in Paroxysmal Nocturnal Hemoglobinuria Patients." Blood 142, Supplement 1 (2023): 1350. http://dx.doi.org/10.1182/blood-2023-178384.

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Background: Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hematopoietic stem cell disease in which abnormal complement activation results in hemolysis and thromboembolic events (TEE). Complement inhibitors (CI) have been proved to be able to suppress intravascular hemolysis (IVH) and reduce the risk of TEE. Few studies were available on the changes of complement deposition after CI and their relationship with efficacy. Methods: PNH patients treated with full dose eculizumab, crovalimab or iptacopan at Peking Union Medical Colleague Hospital from Oct 2021 to Jul 2023 were enrolled.Pa

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Pangburn, M. K., and N. Rawal. "Structure and function of complement C5 convertase enzymes." Biochemical Society Transactions 30, no. 6 (2002): 1006–10. http://dx.doi.org/10.1042/bst0301006.

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The multisubunit enzymes of the complement system that cleave C5 have many unusual properties, the most striking of which is that they acquire their specificity for C5 following cleavage of another substrate C3. C5 convertases are assemblies of two proteins C4b and C2a (classical or lectin pathways) or C3b and Bb (alternative pathway) and additional C3b molecules. The catalytic complexes (C4b, C2a or C3b, Bb) are intrinsically unstable (t1,2 = 1–3 min) and the enzymes are controlled by numerous regulatory proteins that accelerate this natural decay rate. Immediately after assembly, the bi-mole

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Mullick, Jayati, Akhilesh K. Singh, Yogesh Panse, Vivekanand Yadav, John Bernet, and Arvind Sahu. "Identification of Functional Domains in Kaposica, the Complement Control Protein Homolog of Kaposi's Sarcoma-Associated Herpesvirus (Human Herpesvirus 8)." Journal of Virology 79, no. 9 (2005): 5850–56. http://dx.doi.org/10.1128/jvi.79.9.5850-5856.2005.

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ABSTRACT Recently it has been shown that kaposica, an immune evasion protein of Kaposi's sarcoma-associated herpesvirus, inactivates complement by acting on C3-convertases by accelerating their decay as well as by acting as a cofactor in factor I-mediated inactivation of their subunits C3b and C4b. Here, we have mapped the functional domains of kaposica. We show that SCRs 1 and 2 (SCRs 1-2) and 1-4 are essential for the classical and alternative pathway C3-convertase decay-accelerating activity (DAA), respectively, while the SCRs 2-3 are required for factor I cofactor activity (CFA) for C3b an

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Nickells, M. W., V. B. Subramanian, L. Clemenza, and J. P. Atkinson. "Identification of complement receptor type 1-related proteins on primate erythrocytes." Journal of Immunology 154, no. 6 (1995): 2829–37. http://dx.doi.org/10.4049/jimmunol.154.6.2829.

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Abstract The purpose of this study was to characterize the structure and function of the immune adherence receptor (CR1, CD35, C3b/C4b receptor) of primates. Western blotting, immunoprecipitation, ELISA, and affinity chromatography with homologous C3b and C4b were utilized. The major cross-reactive E membrane protein of ten species of primates tested was lower in m.w. than was human CR1 and fell into two size groups of 55 to 75 and 130 to 165 kDa. There was 10- to 100-fold more CR1 per primate E than human E. Five species also expressed lesser quantities of a protein similar in m.w. (approxima

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White, D. J., R. M. Easton, N. G. Culshaw, et al. "Seismic images of the Grenville Orogen in Ontario." Canadian Journal of Earth Sciences 31, no. 2 (1994): 293–307. http://dx.doi.org/10.1139/e94-028.

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In 1990, Lithoprobe acquired 240 km of seismic-reflection data across parts of the Central Gneiss Belt (CGB) and the Central Metasedimentary Belt (CMB) within the western Grenville Province of southern Ontario. Interpretation of these data in conjunction with geological constraints provided by bedrock mapping supports a model of northwest-directed thrusting and crustal shortening for the Grenville Orogen. Within the CGB, the Parry Sound shear zone is imaged as a 3 km wide zone of reflections dipping southeastward at 20–25° and soling at depths < 7 km in the north and < 3 km in the south

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Lewis, Lisa A., Sanjay Ram, Alpana Prasad, et al. "Defining Targets for Complement Components C4b and C3b on the Pathogenic Neisseriae." Infection and Immunity 76, no. 1 (2007): 339–50. http://dx.doi.org/10.1128/iai.00613-07.

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ABSTRACT Complement is a key arm of the innate immune defenses against the pathogenic neisseriae. We previously identified lipooligosaccharide on Neisseria meningitidis as an acceptor for complement C4b. Little is known about other neisserial targets for complement proteins C3 and C4, which covalently attach to bacterial surfaces and initiate opsonization and killing. In this study we demonstrate that Neisseria gonorrhoeae porin (Por) 1B selectively binds C4b via amide linkages and C3b via ester linkages. Using strains expressing hybrid Por1A/1B molecules, a region spanned by loops 4 and 5 of

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Rani, Richa, Manish Kumar Chatli, Mohan Jairath, Nitin Mehta, and Pavan Kumar. "Storage stability of functional chicken meat bullets coated with composite antimicrobial biodegradable films under different packaging conditions." Animal Production Science 56, no. 11 (2016): 1953. http://dx.doi.org/10.1071/an15107.

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Storage stability of processed chicken meat bullets (CMB) packaged under different packaging conditions in supplementation with composite antimicrobial biodegradable (CAB) films impregnated with 0.5% (v/v) cinnamaldehyde, a natural antimicrobial, was evaluated. Different treatments such as aerobic (aerobic packaged product, CAB-coated product and aerobic packaging), modified atmosphere packaging (MAP; MAP 50 : 50; CO2 and N2, F-MAP; CAB-coated product and MAP) and vacuum (VAC; vacuum packaged, F-VAC; CAB-coated product and vacuum) are assessed for various physico-chemical (pH, thiobarbituric a

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Tibi, Rigobert, Lisa Linville, Christopher Young, and Ronald Brogan. "Classification of Local Seismic Events in the Utah Region: A Comparison of Amplitude Ratio Methods with a Spectrogram‐Based Machine Learning Approach." Bulletin of the Seismological Society of America 109, no. 6 (2019): 2532–44. http://dx.doi.org/10.1785/0120190150.

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Abstract The capability to discriminate low‐magnitude earthquakes from low‐yield anthropogenic sources, both detectable only at local distances, is of increasing interest to the event monitoring community. We used a dataset of seismic events in Utah recorded during a 14‐day period (1–14 January 2011) by the University of Utah Seismic Stations network to perform a comparative study of event classification at local scale using amplitude ratio (AR) methods and a machine learning (ML) approach. The event catalog consists of 7377 events with magnitudes MC ranging from −2 and lower up to 5.8. Events

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Accardo, P., P. Sánchez-Corral, O. Criado, E. García, and S. Rodríguez de Córdoba. "Binding of human complement component C4b-binding protein (C4BP) to Streptococcus pyogenes involves the C4b-binding site." Journal of Immunology 157, no. 11 (1996): 4935–39. http://dx.doi.org/10.4049/jimmunol.157.11.4935.

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Abstract A key step in the elimination of invading pathogens from the body is the covalent binding of complement proteins C3b and C4b to their surface. However, many pathogens have evolved mechanisms to avoid the complement system of the host. Understanding how these mechanisms work may lead to more efficacious forms of therapy. Here we provide an insight into the molecular basis of how Streptococcus pyogenes binds human plasma C4b-binding protein (hC4BP), a complement regulatory molecule that may decrease C3b and C4b deposition on the streptococcal surface. We show that streptococcal surface

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Milanesi, Jovana de Moura, Priscila Weber, Luana Cristina Berwig, Rodrigo Agne Ritzel, Ana Maria Toniolo da Silva, and Eliane Castilhos Rodrigues Corrêa. "Childhood mouth-breathing consequences at adult age: ventilatory function and quality of life." Fisioterapia em Movimento 27, no. 2 (2014): 211–18. http://dx.doi.org/10.1590/0103-5150.027.002.ao06.

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Introduction Mouth breathing can affect the functions of the respiratory systems and quality of life. For this reason, children who grow up with this stimulus may have implications on physical and psychological aspects at adult age.Objective To evaluate childhood mouth-breathing consequences for the ventilatory function and quality of life at adult age.Materials and methods Prospective, observational and cross-sectional study with 24 adults, between 18 and 30 years old, mouth breathers during childhood, comprised the childhood mouth-breathing group (CMB). The childhood nasal-breathing (CNB) gr

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Jang, Hyunsoo, Jisu Lee, Sebin Won, et al. "Physicochemical Properties, Antioxidant Capacities, and Sensory Evaluation of Yanggaeng Treated with Cissus quadrangularis." Applied Sciences 13, no. 19 (2023): 11092. http://dx.doi.org/10.3390/app131911092.

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This study investigated the impact of incorporating Cissus quadrangularis (CQ) powder into Yanggaeng, a traditional Korean food, focusing on its functional properties. This study examined the proximate composition, physicochemical characteristics, antioxidant capabilities, sensory attributes, and consumer preferences of Yanggaeng when treated with different levels (CON [0%], CQ2 [2%], CQ4 [4%], and CQ6 [6%]) of CQ powder. Yanggaeng with CQ powder exhibited a significantly reduced pH, and among the CQ additive groups the highest °Brix value was observed in CQ2. The water holding capacity (WHC)

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Murray, Hannah, Beiying Qiu, Sze Yuan Ho, and Xiaomeng Wang. "Complement Factor B Mediates Ocular Angiogenesis through Regulating the VEGF Signaling Pathway." International Journal of Molecular Sciences 22, no. 17 (2021): 9580. http://dx.doi.org/10.3390/ijms22179580.

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Complement factor B (CFB), a 95-kDa protein, is a crucial catalytic element of the alternative pathway (AP) of complement. After binding of CFB to C3b, activation of the AP depends on the proteolytic cleavage of CFB by factor D to generate the C3 convertase (C3bBb). The C3 convertase contains the catalytic subunit of CFB (Bb), the enzymatic site for the cleavage of a new molecule of C3 into C3b. In addition to its role in activating the AP, CFB has been implicated in pathological ocular neovascularization, a common feature of several blinding eye diseases, however, with somewhat conflicting re

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Klickstein, L. B., T. J. Bartow, V. Miletic, L. D. Rabson, J. A. Smith, and D. T. Fearon. "Identification of distinct C3b and C4b recognition sites in the human C3b/C4b receptor (CR1, CD35) by deletion mutagenesis." Journal of Experimental Medicine 168, no. 5 (1988): 1699–717. http://dx.doi.org/10.1084/jem.168.5.1699.

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Complementary DNA clones encoding the NH2-terminal region of human CR1 have been isolated and sequenced. The deduced complete amino acid sequence of the F allotype of human CR1 contains 2,039 residues, including a 41-residue signal peptide, an extracellular domain of 1,930 residues, a 25-amino acid transmembrane domain, and a 43-amino acid cytoplasmic region. The extracellular domain is composed exclusively of 30 short consensus repeats (SCRs), characteristic of the family of C3/C4-binding proteins. The 28 NH2-terminal SCRs are organized as four long homologous repeats (LHRs) of seven SCRs eac

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Kalli, K. R., and D. T. Fearon. "Binding of C3b and C4b by the CR1-like site in murine CR1." Journal of Immunology 152, no. 6 (1994): 2899–903. http://dx.doi.org/10.4049/jimmunol.152.6.2899.

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Abstract We determined whether the six short consensus repeats (SCRs) that are appended to the amino terminus of murine CR2 to form murine CR1 contain a binding site for C4b in addition to that for C3b, and whether these sites overlap or are distinct. Human K562 transfectant cell lines were established that stably expressed constructs encoding variable combinations of these six murine SCRs attached to the amino terminus of a truncated form of human CR2 lacking its iC3b/C3dg binding site. These cell lines, and two others expressing full-length human CR1 and SCRs lacking its iC3b/C3dg binding si

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Seya, T., S. Nagasawa, and J. P. Atkinson. "C4b-binding protein and a 60,000-Dalton plasma protein share antigenic determinants with membrane cofactor protein of complement." Journal of Immunology 144, no. 6 (1990): 2312–20. http://dx.doi.org/10.4049/jimmunol.144.6.2312.

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Abstract Membrane cofactor protein (MCP) of the C system is a widely distributed regulatory molecule with C3b/C4b binding and factor I-dependent cofactor activity. A rabbit polyclonal antibody was raised against purified human MCP, and it was found to also immunoprecipitate C4b-binding protein (C4bp). Other related complement regulatory proteins, factor H, C3b/C4b receptor, and decay-accelerating factor, were not recognized by this polyclonal antibody to MCP. The cross-reactive epitope was sensitive to reduction with 2-ME and about 3% of the anti-MCP antibody reacted with C4bp. The amino-termi

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