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Labes, Antje, und Peter Schönheit. „Unusual Starch Degradation Pathway via Cyclodextrins in the Hyperthermophilic Sulfate-Reducing Archaeon Archaeoglobus fulgidus Strain 7324“. Journal of Bacteriology 189, Nr. 24 (05.10.2007): 8901–13. http://dx.doi.org/10.1128/jb.01136-07.
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ABSTRACT The hyperthermophilic archaeon Archaeoglobus fulgidus strain 7324 has been shown to grow on starch and sulfate and thus represents the first sulfate reducer able to degrade polymeric sugars. The enzymes involved in starch degradation to glucose 6-phosphate were studied. In extracts of starch-grown cells the activities of the classical starch degradation enzymes, α-amylase and amylopullulanase, could not be detected. Instead, evidence is presented here that A. fulgidus utilizes an unusual pathway of starch degradation involving cyclodextrins as intermediates. The pathway comprises the combined action of an extracellular cyclodextrin glucanotransferase (CGTase) converting starch to cyclodextrins and the intracellular conversion of cyclodextrins to glucose 6-phosphate via cyclodextrinase (CDase), maltodextrin phosphorylase (Mal-P), and phosphoglucomutase (PGM). These enzymes, which are all induced after growth on starch, were characterized. CGTase catalyzed the conversion of starch to mainly β-cyclodextrin. The gene encoding CGTase was cloned and sequenced and showed highest similarity to a glucanotransferase from Thermococcus litoralis. After transport of the cyclodextrins into the cell by a transport system to be defined, these molecules are linearized via a CDase, catalyzing exclusively the ring opening of the cyclodextrins to the respective maltooligodextrins. These are degraded by a Mal-P to glucose 1-phosphate. Finally, PGM catalyzes the conversion of glucose 1-phosphate to glucose 6-phosphate, which is further degraded to pyruvate via the modified Embden-Meyerhof pathway.
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Bansal, Paramjit S., Craig L. Francis, Noel K. Hart, Scott A. Henderson, David Oakenfull, Alan D. Robertson und Gregory W. Simpson. „Regioselective Alkylation of β-Cyclodextrin“. Australian Journal of Chemistry 51, Nr. 10 (1998): 915. http://dx.doi.org/10.1071/c98064.
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Methodology for preparation of heptakis(2,6-di-O-alkyl)-β-cyclodextrins, heptakis(2-O-alkyl)-β- cyclodextrins, and heptakis(6-O-alkyl)-β-cyclodextrins in substantially purified form has been developed. Treatment of β-cyclodextrin (1) with sodium or barium hydroxide and various alkyl halides in dimethyl sulfoxide or a mixture of dimethyl sulfoxide and N,N-dimethylformamide provided the corresponding heptakis(2,6-di-O-alkyl)-β-cyclodextrins. Treatment of heptakis(6-O-t-butyldimethylsilyl)-β-cyclodextrin (5) with sodium hydroxide and several haloalkanes in dimethyl sulfoxide followed by desilylation provided heptakis(2-O-alkyl)-β-cyclodextrins. Protection of the secondary hydroxy groups of the t-butyldimethylsilyl-β-cyclodextrin (5) as benzyl ethers, followed by desilylation, alkylation, and debenzylation afforded several heptakis(6-O-alkyl)-β-cyclodextrins. Analytical methodology has been developed to characterize all of these compounds, with the homogeneity of the pattern of substitution verified by h.p.l.c. analysis, f.a.b.–mass spectrometry and n.m.r. spectroscopy.
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Wang, Runmiao, Hui Zhou, Shirley W. I. Siu, Yong Gan, Yitao Wang und Defang Ouyang. „Comparison of Three Molecular Simulation Approaches for Cyclodextrin-Ibuprofen Complexation“. Journal of Nanomaterials 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/193049.
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Cyclodextrins are widely used for the solubilisation of poorly soluble drugs in the formulations. However, current cyclodextrin formulation development strongly depends on trial-and-error in the laboratory, which is time-consuming and high cost. The aim of this research was to compare three modeling approaches (Docking, molecular dynamics (MD), and quantum mechanics (QM)) for cyclodextrin/drug complexation. Ibuprofen was used as a model drug. Binding free energy from three simulation methods was calculated as an important parameter to compare with the experimental results. Docking results from AutoDock Vina program showed that the scoring of complexation capability between ibuprofen and cyclodextrins is alpha (α), gamma (γ), beta (β), and HP-beta-cyclodextrins, which indicated similar ranking with the results from phase, solubility diagram experiments. MD simulation indicated that ibuprofen could form the stable complexes withβ-,γ-, and HP-β-cyclodextrins, but not for alpha cyclodextrin. Binding free energies from the MD simulation forβ-,γ-, and HP-β-cyclodextrins were −3.67, −0.67, and −3.87 kcal/mol, individually. The enthalpies of QM simulation forβ-,γ-, and HP-β-cyclodextrins were −17.22, −14.75, and −20.28 kcal/mol, respectively. Results from all three modeling approaches showed similar ranking between ibuprofen and four cyclodextrin molecules as the experimental data. However, MD simulation with entropy calculation had the closest value to experimental data forβand HP-beta-cyclodextrins. Thus, MD simulation with MM-PBSA method may be fit toin silicoscreen for cyclodextrin formulations.
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Lavandier, CD, MP Pelletier und VC Reinsborough. „Surfactant Inclusions by Modified β-Cyclodextrins“. Australian Journal of Chemistry 44, Nr. 3 (1991): 457. http://dx.doi.org/10.1071/ch9910457.
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Binding constants for the inclusion of sodium alkane-1-sulfonates (C5-C10, C12) by four modified β- cyclodextrins (2,6-O-dimethyl-β-cyclodextrin, 2,3,6-O-trimethyl-β-cyclodextrin, hydroxypropyl-β-cyclodextrin and maltosyl-β-cyclodextrin ) were determined conductimetrically at 25°C. Binding increased with increasing length of the alkyl chain. Generally, the substituted β- cyclodextrins were no more effective as encapsulating agents than ordinary β- cyclodextrin with the persubstituted 2,3,6-O-trimethyl-β-cyclodextrin being the weakest.
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Easton, Christopher J., Steven J. van Eyk, Stephen F. Lincoln, Bruce L. May, John Papageorgiou und Michael L. Williams. „A Versatile Synthesis of Linked Cyclodextrins“. Australian Journal of Chemistry 50, Nr. 1 (1997): 9. http://dx.doi.org/10.1071/c96168.
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Reactions of amino-substituted cyclodextrins with bis(3-nitrophenyl) oxalate, malonate, succinate and glutarate, and with diphenyl carbonate, afford a range of linked cyclodextrins. These include α- and β-cyclodextrin dimers, joined by substitution at either C6 or C3, and asymmetric species with a β-cyclodextrin bonded to an a-cyclodextrin and a C3-substituted cyclodextrin attached to a C6-substituted moiety.
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Fenyvesi, Ferenc. „Biological Studies on Cyclodextrins“. Proceedings 78, Nr. 1 (01.12.2020): 60. http://dx.doi.org/10.3390/iecp2020-08692.
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In recent years, our knowledge of the biological effects of cyclodextrins has grown significantly. Cellular actions of cyclodextrins originate in their ability to form complexes with lipophilic biomolecules. Cyclodextrins can target different types of molecules according to their size, for instance, alpha-cyclodextrins form complexes with phospholipids, while beta-cyclodextrins can bind cholesterol or prostaglandin E2. Due to their interactions with the main membrane constituents, cyclodextrins can affect the barrier function of biological barriers or influence the function of membrane proteins. Nevertheless, cyclodextrins can enter the cells by endocytosis and affect the intracellular cholesterol storage. Based on these findings, 2-hydroxypropyl-beta cyclodextrin (HPBCD) received the orphan designation for the treatment of Niemann–Pick disease type C. The endocytosis of cyclodextrins works in different cell types and can be applied in the delivery of drugs into the cells. The tissue distribution and pharmacokinetics of cyclodextrins could be further characterized by imaging techniques. Radiolabeled HPBCD and randomly methylated beta-cyclodextrin (RAMEB) were recently used to study their in vivo behavior by positron emission tomography. Interestingly, RAMEB accumulation was detected in prostaglandin E2 (PGE2)-positive tumors. These findings can promote further research and the application of cyclodextrins in inflammation and tumor diagnosis or targeting. The presentation aims to give an overview of the main biological effects of cyclodextrins and the recent results of this research field.
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Yhaya, Firdaus, Andrew M. Gregory und Martina H. Stenzel. „Polymers with Sugar Buckets - The Attachment of Cyclodextrins onto Polymer Chains“. Australian Journal of Chemistry 63, Nr. 2 (2010): 195. http://dx.doi.org/10.1071/ch09516.
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This Review summarizes the structures obtained when marrying synthetic polymers of varying architectures with cyclodextrins. Polymers with cyclodextrin pendant groups were obtained by directly polymerizing cyclodextrin-based monomers or by postmodification of reactive polymers with cyclodextrins. Star polymers with cyclodextrin as the core with up to 21 arms were usually obtained by using modified cyclodextrins as initiator or controlling agent. Limited reports are available on the synthesis of star polymers by arm-first techniques, which all employed azide-functionalized cyclodextrin and ‘click’ chemistry to attach seven polymer arms to the cyclodextrin core. Polymer chains with one or two cyclodextrin terminal units were reported as well as star polymers carrying a cyclodextrin molecule at the end of each arm. Cyclodextrin polymers were obtained using different polymerization techniques ranging from atom transfer radical polymerization, reversible addition–fragmentation chain transfer polymerization, nitroxide-mediated polymerization, free radical polymerization to (ionic) ring-opening polymerization, and polycondensation. Cyclodextrin polymers touch all areas of polymer science from gene delivery, self-assembled structures, drug carriers, molecular sensors, hydrogels, and liquid crystalline polymers. This Review attempts to focus on the range of work conducted with polymers and cyclodextrins and highlights some of the key areas where these macromolecules have been applied.
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Sivakumar, Ponnurengam M., Shohreh Peimanfard, Ali Zarrabi, Arezoo Khosravi und Matin Islami. „Cyclodextrin-Based Nanosystems as Drug Carriers for Cancer Therapy“. Anti-Cancer Agents in Medicinal Chemistry 20, Nr. 11 (08.07.2020): 1327–39. http://dx.doi.org/10.2174/1871520619666190906160359.
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Background and Objective: Cyclodextrins have been of great interest as excellent candidates for fabricating versatile nano-drug delivery systems due to their commercial availability, easy functionalization, low immunogenicity, biocompatibility and safety. The possibility of reversible inclusion complex formation between cyclodextrins and various guest molecules in association with versatile exclusive properties of cyclodextrins offer a route towards the fabrication of highly sophisticated nanostructures with enormous potential for cancer treatment. Methods and Results: The current review discusses important recent advances in the fabrication and development of cyclodextrin-based nanostructures for cancer therapy. Firstly, the formation of inclusion complexes between cyclodextrin derivatives and anticancer compounds, as well as their application, are summarized. Secondly, the cyclodextrins -based nanosystems including cyclodextrin-containing polymers, cyclodextrin-based supramolecular necklaces, which consist of polyrotaxanes and polypseudorotaxanes and cyclodextrin based hydrogels accompanied by their applications in cancer treatment are highlighted. In the end, the future perspective of this field is discussed. Conclusion: Numerous investigations in this area pave the way for the flourishing of the next generation of nano-therapeutics towards enhanced cancer therapy.
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Masoumi, Saeideh, Sahar Amiri und Seyed Hajir Bahrami. „PCL-based nanofibers containing ibuprofen/cyclodextrins nanocontainers: A potential candidate for drug delivery application“. Journal of Industrial Textiles 48, Nr. 9 (21.03.2018): 1420–38. http://dx.doi.org/10.1177/1528083718764910.
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Poor solubility and low dissolution rate of ibuprofen (IBU) in the aqueous gastro-intestinal fluids restrict its application, absorption, distribution, target organ delivery, and bioavailability. For improvement of aqueous solubility of IBU, supramolecular nanocontainers of IBU/cyclodextrin were prepared via formation of inclusion complex between ibuprofen and cyclodextrins (α-cyclodextrin and β-cyclodextrin) at various conditions (at room temperature at 25℃ and under sonic energy). The formation of inclusion complex between IBU and cyclodextrins can be confirmed by hydrogen nuclear magnetic resonance, differential scanning calorimetry, fourier transform Infrared spectroscopy (FTIR), X-ray diffraction, and scanning electron microscopy study. FTIR of pure IBU and cyclodextrins is similar to the obtained complex, which indicated intactness of drug in the complex. The encapsulation of IBU in cyclodextrins cavity improved its solubility, phase solubility, and in vitro dissolution and also controlled its release which ensures the long-term delivery. Electro-spun nanofibers of poly-ɛ-caprolactone containing IBU/cyclodextrins is a promising method for controlled drug delivery electro-spun which is bead-free without any aggregation on the surface.
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Prior, Marguerite, Sylvain Lehmann, Man-Sun Sy, Brendan Molloy und Hilary E. M. McMahon. „Cyclodextrins Inhibit Replication of Scrapie Prion Protein in Cell Culture“. Journal of Virology 81, Nr. 20 (15.08.2007): 11195–207. http://dx.doi.org/10.1128/jvi.02559-06.
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ABSTRACT Prion diseases are fatal neurodegenerative disorders that are caused by the conversion of a normal host-encoded protein, PrPC, to an abnormal, disease-causing form, PrPSc. This paper reports that cyclodextrins have the ability to reduce the pathogenic isoform of the prion protein PrPSc to undetectable levels in scrapie-infected neuroblastoma cells. Beta-cyclodextrin removed PrPSc from the cells at a concentration of 500 μM following 2 weeks of treatment. Structure activity studies revealed that antiprion activity was dependent on the size of the cyclodextrin. The half-maximal inhibitory concentration (IC50) for beta-cyclodextrin was 75 μM, whereas α-cyclodextrin, which possessed less antiprion activity, had an IC50 of 750 μM. This report presents cyclodextrins as a new class of antiprion compound. For decades, the pharmaceutical industry has successfully used cyclodextrins for their complex-forming ability; this ability is due to the structural orientation of the glucopyranose units, which generate a hydrophobic cavity that can facilitate the encapsulation of hydrophobic moieties. Consequently, cyclodextrins could be ideal candidates for the treatment of prion diseases.
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Brown, Susan Elizabeth. „Molecular recognition by cyclodextrins /“. Title page, contents and abstract only, 1994. http://web4.library.adelaide.edu.au/theses/09PH/09phb8798.pdf.
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Yan, Jinglan. „Sulfated ß-cyclodextrins in enantiomeric separations and mobility conservation model in cyclodextrin-mediated capillary electrophoresis“. Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ35009.pdf.
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Copy of author's previously published article inserted. Includes bibliographies This thesis studies the B-cyclodextrins which are modified at the primary rim to incorporate an additional coordination or hydrophobic recognition site. The natural organic host, cyclodextrin and its chemically modified derivatives, are utilised as hosts for the inclusion of a range of guests. The study contributes to understanding the fundamental factors influencing selectivity of binding and the stability of the complexes formed when a guest is bound essentially at two recognition sites.
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Kean, Suzanna Dawn. „Modified cyclodextrins and their complexes“. Title page, contents and abstract only, 1999. http://web4.library.adelaide.edu.au/theses/09PH/09phk243.pdf.
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Addendum page pasted onto front end paper. Copies of author's previously published articles inserted. Includes bibliographical references. Investigates the factors that govern the stability of cyclodextrin inclusion complexes with a range of systematically modified cyclodextrins.
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Palmer, Simon Richard Faunch. „Electroanalytical sensors using lipophilic cyclodextrins“. Thesis, Durham University, 1997. http://etheses.dur.ac.uk/4753/.
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Lipophilic dialkylated-a-, β- and γ-cyclodextrin derivatives were used as selective ionophores for a series of clinically relevant ammonium ions, and as enantioselective ionophores for both a- and β-aryl ammonium ions. Sensitive and selective potentiometric detection of the local anaesthetics lidocaine and bupivacaine was achieved by using 2,3,6 trioctyl-β-cyclodextrin as the ionophore, leading to micromolar detection limits. Interference studies showed that the simulated clinical electrolyte background caused minimal interference whereas organic interferents of similar size and charge caused some perturbation of the electrode response at a concentration of 10 mmol dm(^-3). An electrode comprising a plasticized biocompatible membrane matrix, TECOFLEX, with 2,6 didodecyl-β-cyclodextrin was incorporated in a flow injection analysis system and the response to lidocaine studied in the presence of human serum. Human serum caused no adverse effects to the electrochemical response of the electrode. These electrodes are, therefore, very suitable for on-line detection of local anaesthetics. Potentiometric detection of tricyclic antidepressants using didodecyl-a-, β- and γ- cyclodextrins as the ionophore, gave micromolar detection limits. Interference from simulated clinical electiolyte background and selected organic interferents gave similar results to those discussed above. In order to lower the detection limit to sub-nanomolar levels modified amperometric electrodes were assembled by depositing a membrane comprising plasticised TECOFLEX, 2,3,6 triethyl-β-cyclodextrin and TKB on the working electrode of a screen printed electrode. Lipophilic 2,6 didodecyl-a- and β-cyclodextrins exhibited enantiomeric discrimination in the binding of propranolol, ephedrine, amphetamine and methamphetamine. These results were confirmed using potentiometric and NMR techniques.
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Jones, S. P. „Interaction of drugs with cyclodextrins“. Thesis, University of Nottingham, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355923.
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De, Vries Elise Janine Christl. „Inclusion of alkylparabens in cyclodextrins“. Doctoral thesis, University of Cape Town, 2003. http://hdl.handle.net/11427/6302.
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Includes bibliographical references. The aim of this thesis was to prepare crystalline inclusion complexes with cyclodextrins (CDs), as hosts, and drugs, as guests, characterise them using various methods and attempt to elucidate their structures by X-ray diffraction methods to establish the detailed mode of drug inclusion in the solid state. Cyclodextrins and their derivatives have a low polarity central void formed by linked glucose residues of varying numbers. This annular cavity is able to encapsualte low molecular weight molecules and is therefore responsible for the great interest in CDs in host-guest chemistry. In addition, inclusion of drug molecules in cyclodextrins can significantly improve aspects of their performance, such as increased aqueous solubility and dissolution rates which lead to their increasing application in the pharmaceutical industry.
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Al-Derbali, Meftah Abdulhafied. „Formulation and evaluation of zidovudine cyclodextrin inclusion complex to enhance acid lability and palatability“. University of the Western Cape, 2016. http://hdl.handle.net/11394/5052.
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Magister Pharmaceuticae - MPharm Background: Zidovudine (AZT) is a very useful drug for the management of Human
Immunodeficiency Virus (HIV) infection. Its optimal use is limited by its bitter taste, sparing solubility (20.1 mg/ml) and acid lability. Cyclodextrins (CD) are a class of compounds which can be used to form inclusion complexes with drugs such as AZT to improve it is taste, solubility and palatability. Purpose: This study complexed hydroxypropyl-beta-cyclodextrin (HPβCD) with AZT. The formulated inclusion complex was evaluated for suitability as a dosage form and as a tool for improving AZT’s palatability, solubility and acid liability. Method: AZT was complexed with HPβCD using the lyophilisation method. The binding constant for the formulation was determined by the phase solubility method, and complex formation between AZT and HPβCD evaluated using proton nuclear magnetic resonance (1H NMR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and hot stage microscopy (HSM). Tablets of the inclusion complex were formulated by direct compression, using the least possible amount of excipients, and the dosage form evaluated for hardness, friability, durability, disintegration time and dissolution. Results: The binding constant of the formulation was 3.919, and the degree of incorporation was 4.0 mg AZT/g of CD per complex. 1H NMR showed significant chemical shifts between the inclusion complex and AZT. DSC and TGA analyses showed significant differences in the curves for the pure AZT and HPβCD. Values for tablet hardness, friability, durability and disintegration time were 236 ± 20 N, 0.7 %, 1.02 % and 10.25 minutes, respectively. The solubility of the formulation was 148.08 mg/ml, and its dissolution profile was different from that of the branded formulation. Conclusions: AZT-HPβCD inclusion complex, with a 7.4-fold increase in AZT solubility, was successfully prepared using the lyophilisation method. The binding constant and friability of the formulation were within acceptable limits. Although the hardness value is high, the tablet still disintegrated within acceptable specified times. This study has significant implications for anti-retroviral complex formulations.
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Lock, Julia. „Cyclodextrins : molecular wheels for supramolecular chemistry /“. Title page, table of contents and abstract only, 2004. http://web4.library.adelaide.edu.au/theses/09PH/09phl8131.pdf.
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Thesis (Ph.D.)--University of Adelaide, School of Chemistry and Physics, Discipline of Chemistry, 2005? "July 2004" Includes copies of publications by the author as appendix. Includes bibliographical references.
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Frömming, Karl-Heinz, und József Szejtli. Cyclodextrins in Pharmacy. Dordrecht: Springer Netherlands, 1994. http://dx.doi.org/10.1007/978-94-015-8277-3.
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Crini, Grégorio, Sophie Fourmentin und Eric Lichtfouse, Hrsg. The History of Cyclodextrins. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-49308-0.
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Robyt, John F. „Cyclodextrins“. In Springer Advanced Texts in Chemistry, 245–61. New York, NY: Springer New York, 1998. http://dx.doi.org/10.1007/978-1-4612-1622-3_8.
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Trotta, Francesco. „Cyclodextrins“. In Encyclopedia of Membranes, 507–8. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-44324-8_2045.
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Frömming, Karl-Heinz, und József Szejtli. „Cyclodextrins“. In Topics in Inclusion Science, 1–18. Dordrecht: Springer Netherlands, 1994. http://dx.doi.org/10.1007/978-94-015-8277-3_1.
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Sá Couto, André, Paulo Salústio und Helena Cabral-Marques. „Cyclodextrins“. In Polysaccharides, 247–88. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-16298-0_22.
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Trotta, Francesco. „Cyclodextrins“. In Encyclopedia of Membranes, 1–3. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-40872-4_2045-1.
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Salmaso, Stefano, und Fabio Sonvico. „Targeted Cyclodextrins“. In Cyclodextrins in Pharmaceutics, Cosmetics, and Biomedicine, 251–73. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2011. http://dx.doi.org/10.1002/9780470926819.ch13.
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Russell, N. R., und M. McNamara. „Metallo — Cyclodextrins“. In Proceedings of the Eighth International Symposium on Cyclodextrins, 163–69. Dordrecht: Springer Netherlands, 1996. http://dx.doi.org/10.1007/978-94-011-5448-2_34.
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Konferenzberichte zum Thema "Cyclodextrins":
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Nozawa, Ryo, Mohammad Ferdows, Kazuhiko Murakami und Masahiro Ota. „Effects of Cyclodextrin Solutions on Methane Hydrate Formation“. In ASME/JSME 2007 Thermal Engineering Heat Transfer Summer Conference collocated with the ASME 2007 InterPACK Conference. ASMEDC, 2007. http://dx.doi.org/10.1115/ht2007-32987.
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In this paper, we suggest the advanced method of methane hydrate formation by cyclodextrin solutions. The structures of the methane hydrate were experimentally investigated by Raman spectroscopy. The induction time of the methane hydrate formation becomes by shorter 10–30 times and formation rate become by faster 2–4 times originated in the increased methane concentration of hydrate formation water by adding cyclodextrins. The results by the Raman spectroscopy indicate that the structure I methane hydrate is produced and methane molecules exist in both Large and Small cages.
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Jicsinszky, Laszlo, und Robert Ivanyi. „SELECTIVE SUBSTITUTION OF CYCLODEXTRINS: PREPARATION OF NITROGEN CONTAINING CYCLODEXTRINS“. In XXIst International Carbohydrate Symposium 2002. TheScientificWorld Ltd, 2002. http://dx.doi.org/10.1100/tsw.2002.392.
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Zavodnik, I. B., E. A. Lapshina, T. V. Ilyich, A. G. Veiko, T. A. Kovalenia und V. U. Buko. „REGULATORY, ANTIOXIDATIVE AND HEPATOPROTECTIVE EFFECTS OF PLANT POLYPHENOLS AND THEIR NANOSTRUCTURED COMPLEXES“. In SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY. International Sakharov Environmental Institute, 2021. http://dx.doi.org/10.46646/sakh-2021-1-255-258.
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Flavonoids, secondary plant metabolites, demonstrate a wide range of biological and pharmacological activities. In our experiment, flavonoids and their complexes with cyclodextrins (10—100 gM) dose-dependently prevented lipid peroxidation of erythrocyte and mitochondrial membranes, inhibited oxidation of reduced glutathione, and modulated the proapoptotic process of the mitochondrial permeability transition pores formation, that depends on flavonoid lipophilicity and structures. Generation of maps of the electron density distribution in the quercetin molecule and the quercetin semiquinone radical shows that the active electronic orbitals of quercetin and its semiquinone radical are delocalized along the phenolic rings, which, in the case of a radical, increases radical stability. The quercetin-hydroxypropyl-e-cyclodextrin complex proved to be a more effective antioxidant.
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Bednarz, Szczepan, Marcin Lukasiewicz, Wojciech Mazela, Michal Pajda, Stanislaw Kowalski, Sabina Foks, Anna Garlicka, Maciej Kabzinski und Kacper Kaczmarczyk. „Processes of Cyclodextrins grafting on cotton“. In The 11th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2007. http://dx.doi.org/10.3390/ecsoc-11-01355.
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Papezhuk, M. V., A. V. Chemodanova, V. A. Volynkin und V. T. Panyushkin. „FUNCTIONALIZED CYCLODEXTRINS FOR TARGETED DRUG TRANSPORT“. In MedChem-Russia 2021. 5-я Российская конференция по медицинской химии с международным участием «МедХим-Россия 2021». Издательство Волгоградского государственного медицинского университета, 2021. http://dx.doi.org/10.19163/medchemrussia2021-2021-502.
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Ambrus, Rita, Csilla Bartos, Gábor Katona, Tamás Kiss, Zoltán Aigner und Piroska Szabó-Révész. „Cyclodextrins in traditional and alternative drug formulations“. In The 1st International Electronic Conference on Pharmaceutics. Basel, Switzerland: MDPI, 2020. http://dx.doi.org/10.3390/iecp2020-08912.
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Alvarez-Lorenzo, Carmen. „Cyclodextrins as multipurpose materials for bone regeneration“. In The 1st International Electronic Conference on Pharmaceutics. Basel, Switzerland: MDPI, 2020. http://dx.doi.org/10.3390/iecp2020-08688.
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Ueno, Akihiko, Hiroshi Ikeda und Taiyo Aoyagi. „Signal transduction in chemosensors of modified cyclodextrins“. In BiOS '97, Part of Photonics West, herausgegeben von Richard B. Thompson. SPIE, 1997. http://dx.doi.org/10.1117/12.273523.
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Wirén, Charlotta, Mònica Campàs, Maria Rambla-Alegre, Anna Safont, Carles Alcaraz, Jorge Diogène, Mabel Torréns und Alex Fragoso. „Cyclodextrins as capture agents of lipophilic marine toxins“. In 1st International Electronic Conference on Toxins. Basel, Switzerland: MDPI, 2021. http://dx.doi.org/10.3390/iect2021-09170.
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Wu, Wei, Chen Yu jie, Li xing Luan, Wei guang Pu und San xiong He. „Preparation and Characterization of Conjugated Polypseudorotaxanes Polypyrrole/Cyclodextrins“. In 2009 MRS Fall Meetin. Materials Research Society, 2009. http://dx.doi.org/10.1557/proc-1272-ll03-01.
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Berichte der Organisationen zum Thema "Cyclodextrins":
1
Hunt, J., A. Wagner und T. Michalski. Application of sup 252 CF-PDMS in the analysis of cyclodextrins and their derivatives. Office of Scientific and Technical Information (OSTI), Januar 1990. http://dx.doi.org/10.2172/6985784.
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2
Young, Sandra K., Peter L. Vajda, Eugene Napadensky, Dawn M. Crawford und James M. Sloan. Structure-Scavenging Abilities of Cyclodextrin-Based Polyurethanes. Fort Belvoir, VA: Defense Technical Information Center, Juli 2002. http://dx.doi.org/10.21236/ada406085.
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3
Li, DeQuan. Cyclodextrin-based chemical microsensors for Volatile Organic Compounds (VOCs). Office of Scientific and Technical Information (OSTI), Dezember 1998. http://dx.doi.org/10.2172/562505.
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4
RHODE ISLAND UNIV KINGSTON. Cyclodextrin-Enhanced In Situ Removal of Organic Contaminants from Groundwater at Department of Defense Sites. Fort Belvoir, VA: Defense Technical Information Center, Mai 2004. http://dx.doi.org/10.21236/ada607331.
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5
Dr. Thieo Hogen-Esch. Complex formation of beta-cyclodextrin in aqueous media with poly(N,N-dimethylacrylamide)containing pendent perfluorooctanesulfonamido groups. Final Report, September 15, 1998 - September 14, 1999. Office of Scientific and Technical Information (OSTI), November 1999. http://dx.doi.org/10.2172/756725.
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Choudhary, Ruplal, Victor Rodov, Punit Kohli, Elena Poverenov, John Haddock und Moshe Shemesh. Antimicrobial functionalized nanoparticles for enhancing food safety and quality. United States Department of Agriculture, Januar 2013. http://dx.doi.org/10.32747/2013.7598156.bard.
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Annotation:
Original objectives The general goal of the project was to utilize the bactericidal potential of curcumin- functionalizednanostructures (CFN) for reinforcement of food safety by developing active antimicrobial food-contact surfaces. In order to reach the goal, the following secondary tasks were pursued: (a) further enhancement of the CFN activity based on understanding their mode of action; (b) preparing efficient antimicrobial surfaces, investigating and optimizing their performance; (c) testing the efficacy of the antimicrobial surfaces in real food trials. Background to the topic The project dealt with reducing microbial food spoilage and safety hazards. Cross-contamination through food-contact surfaces is one of the major safety concerns, aggravated by bacterial biofilm formation. The project implemented nanotech methods to develop novel antimicrobial food-contact materials based on natural compounds. Food-grade phenylpropanoidcurcumin was chosen as the most promising active principle for this research. Major conclusions, solutions, achievements In agreement with the original plan, the following research tasks were performed. Optimization of particles structure and composition. Three types of curcumin-functionalizednanostructures were developed and tested: liposome-type polydiacetylenenanovesicles, surface- stabilized nanoparticles and methyl-β-cyclodextrin inclusion complexes (MBCD). The three types had similar minimal inhibitory concentration but different mode of action. Nanovesicles and inclusion complexes were bactericidal while the nanoparticlesbacteriostatic. The difference might be due to different paths of curcumin penetration into bacterial cell. Enhancing the antimicrobial efficacy of CFN by photosensitization. Light exposure strengthened the bactericidal efficacy of curcumin-MBCD inclusion complexes approximately three-fold and enhanced the bacterial death on curcumin-coated plastic surfaces. Investigating the mode of action of CFN. Toxicoproteomic study revealed oxidative stress in curcumin-treated cells of E. coli. In the dark, this effect was alleviated by cellular adaptive responses. Under light, the enhanced ROS burst overrode the cellular adaptive mechanisms, disrupted the iron metabolism and synthesis of Fe-S clusters, eventually leading to cell death. Developing industrially-feasible methods of binding CFN to food-contact surfaces. CFN binding methods were developed for various substrates: covalent binding (binding nanovesicles to glass, plastic and metal), sonochemical impregnation (binding nanoparticles to plastics) and electrostatic layer-by-layer coating (binding inclusion complexes to glass and plastics). Investigating the performance of CFN-coated surfaces. Flexible and rigid plastic materials and glass coated with CFN demonstrated bactericidal activity towards Gram-negative (E. coli) and Gram-positive (Bac. cereus) bacteria. In addition, CFN-impregnated plastic material inhibited bacterial attachment and biofilm development. Testing the efficacy of CFN in food preservation trials. Efficient cold pasteurization of tender coconut water inoculated with E. coli and Listeriamonocytogeneswas performed by circulation through a column filled with CFN-coated glass beads. Combination of curcumin coating with blue light prevented bacterial cross contamination of fresh-cut melons through plastic surfaces contaminated with E. coli or Bac. licheniformis. Furthermore, coating of strawberries with CFN reduced fruit spoilage during simulated transportation extending the shelf life by 2-3 days. Implications, both scientific and agricultural BARD Report - Project4680 Page 2 of 17 Antimicrobial food-contact nanomaterials based on natural active principles will preserve food quality and ensure safety. Understanding mode of antimicrobial action of curcumin will allow enhancing its dark efficacy, e.g. by targeting the microbial cellular adaptation mechanisms.
