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1

MONSEES, THOMAS K., WERNER MISKA, and WOLF‐BERNHARD SCHILL. "Enzymatic Digestion of Bradykinin by Rat Sertoli Cell Cultures." Journal of Andrology 17, no. 4 (1996): 375–81. http://dx.doi.org/10.1002/j.1939-4640.1996.tb01803.x.

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ABSTRACT: Sertoli cells play a key role in spermatogenesis. To study the involvement of the kallikrein‐kinin system in the testis, the pattern of bradykinin‐inactivating kininases in rat Sertoli cells was investigated. Exogenous bradykinin (Arg1‐Pro2‐Pro3‐Gly4‐Phe5‐Ser6‐Pro8‐Phe8‐Arg9) is cleaved at Pro7‐Phe8, Phe5‐Ser6, and Gly4‐Phe5, as demonstrated by high performance liquid chromatography analysis. Degradation of bradykinin was strongly inhibited by phosphoramidon and thiorphan, which are specific inhibitors of neutral metalloendopeptidase‐24.11. The kininase type II‐specific inhibitors, c
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Harsányi, Endre, Bashar Bashir, Sana Arshad, et al. "Data Mining and Machine Learning Algorithms for Optimizing Maize Yield Forecasting in Central Europe." Agronomy 13, no. 5 (2023): 1297. http://dx.doi.org/10.3390/agronomy13051297.

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Artificial intelligence, specifically machine learning (ML), serves as a valuable tool for decision support in crop management under ongoing climate change. However, ML implementation to predict maize yield is still limited in Central Europe, especially in Hungary. In this context, we assessed the performance of four ML algorithms (Bagging (BG), Decision Table (DT), Random Forest (RF) and Artificial Neural Network-Multi Layer Perceptron (ANN-MLP)) in predicting maize yield based on four different input scenarios. The collected data included both agricultural data (production (PROD) (ton) and m
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Taldaev, Amir, Roman P. Terekhov, Elizaveta V. Melnik, et al. "Insights into the Cardiotoxic Effects of Veratrum Lobelianum Alkaloids: Pilot Study." Toxins 14, no. 7 (2022): 490. http://dx.doi.org/10.3390/toxins14070490.

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Jervine, protoveratrine A (proA), and protoveratrine B (proB) are Veratrum alkaloids that are presented in some remedies obtained from Veratrum lobelianum, such as Veratrum aqua. This paper reports on a single-center pilot cardiotoxic mechanism study of jervine, proA, and proB in case series. The molecular aspects were studied via molecular dynamic simulation, molecular docking with cardiac sodium channel NaV1.5, and machine learning-based structure–activity relationship modeling. HPLC-MS/MS method in combination with clinical events were used to analyze Veratrum alkaloid cardiotoxicity in pat
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Kotovych, George, John R. Cann, John M. Stewart, and Hitoshi Yamamoto. "NMR and CD conformational studies of bradykinin and its agonists and antagonists: application to receptor binding." Biochemistry and Cell Biology 76, no. 2-3 (1998): 257–66. http://dx.doi.org/10.1139/o98-028.

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Most physiological processes are regulated by peptides that perform their functions by interacting with specific receptors on cells. Specific conformations of the peptides are required for correct interactions to take place, and a knowledge of the biologically important conformation is vital for the understanding of biological function. Over the last few years extensive studies using nuclear magnetic resonance and circular dichroism have been carried out on bradykinin (Arg1-Pro2-Pro3-Gly4-Phe5-Ser6-Pro7-Phe8-Arg9) and its antagonists with the objective of developing new drugs to combat severe
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DiSilvestro, Adrianna N., Lauren T. Wesolowski, Pier L. Semanchik, et al. "PSI-8 Inflammatory cytokine concentrations and gene expression in mature and aging sedentary horses." Journal of Animal Science 102, Supplement_3 (2024): 468–69. http://dx.doi.org/10.1093/jas/skae234.531.

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Abstract Chronic inflammation associated with aging, termed “inflamm-aging” may negatively impact overall animal health. However, the mechanisms of inflamm-aging and, therefore, effective interventions, remain unknown. Nuclear factor erythroid 2-related factor 2 (Nrf2; NFE2L2) is a transcription factor that controls antioxidant gene expression and could be a target for promoting anti-inflammatory pathways. To test the hypothesis that supplementation of nonenzymatic derived antioxidants (Protandim Nrf2 Synergizer, LifeVantage Corporation) would activate Nrf2 and mitigate inflammation, 40 mature
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Queiroz, Pedro, Israel Alves Filho, Sergio Pereira Junior, et al. "PSIX-10 In vitro dry matter digestibility, gas production and pH of silages of several maize hybrids." Journal of Animal Science 98, Supplement_4 (2020): 415–16. http://dx.doi.org/10.1093/jas/skaa278.725.

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Abstract The objective of this study was to determine the in vitro dry matter digestibility (IVDMD), gas production and pH of silages of 10 maize hybrids in Iturama, Brazil (XB 6012 BT, BM 709 VT PRO2, BM 815 VT PRO2, DKB 363 VT PRO3, AG 8740 VT PRO3, SYN 555 VIP3, SX 8555 VIP3, SX 7005 VIP3, DKB 390 VT PRO3, and RB 9789 VIP3). The maize was ensiled in experimental mini silos in a completely randomized design with 3 repetitions. After 120 d, a subsample from each mini silo was taken and the IVDMD was estimated using Ankom Daisy II and F-57 bags (n = 44). Rumen fluid from two cannulated Nellore
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He, Yijie, Kwangwook Kim, Cynthia Jinno, et al. "131 Effects of Bacillus spp. probiotics on systemic immunity and intestinal health of weaned pigs experimentally infected with an enterotoxigenic Escherichia coli." Journal of Animal Science 97, Supplement_2 (2019): 74–75. http://dx.doi.org/10.1093/jas/skz122.137.

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Abstract The experiment was conducted to investigate the effects of Bacillus spp. on systemic immunity and intestinal health of weaned pigs infected with F18 E. coli. Weaned pigs (n = 36, 7.61 ± 0.40 kg BW) were randomly allotted to one of three treatments: a control diet and two diets supplemented with 500 mg/kg of Bacillus spp. strain 1 (PRO1) or strain 2 (PRO2). The experiment was conducted for 28 d, including 7 d before and 21 d after the first E. coli inoculation (d 0). The doses of F18 E. coli inoculum were 1010 cfu/3 mL oral dose daily for 3 consecutive days. Serum samples were collecte
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Manalu, Andre S. B., Rosdiana Naibey, and Tumpal Simatupang. "Hubungan Serumen Prop terhadap Pendengaran Siswa Kelas 5-6 di SD Inpres 17 Kota Sorong." Papua Medicine and Health Science 1, no. 1 (2024): 23–30. https://doi.org/10.64141/pmhs.v1i1.3.

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Serumen prop merupakan produksi serumen yang berlebihan sehingga dapat menutup saluran pendengaran eksternal. Serumen prop dapat mengakibatkan rasa penuh pada telinga, mengganggu pandangan saat melakukan pemeriksaan membran timpani, nyeri, pusing, gangguan pendengaran konduktif, meningkatnya risiko infeksi telinga, dan pada kasus yang parah menyebabkan ketulian dan perforasi membran timpani. Penelitian ini bertujuan untuk mengetahui hubungan serumen prop terhadap pendengaran Siswa Kelas 5-6 di SD Inpres 17 Kota Sorong. Penelitian dilakukan pada siswa-siswi kelas 5-6 SD Inpres 17 sebanyak 65 re
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Halim, Issaora Juni Annisa Tiara Kasih Ria, Mulyadi Tanjung, Ratih Dewi Saputri, Muhamad Fajar Aldin, and Tjittik Srie Tjahjandarie. "Senyawa Isoflavonoid Terisoprenilasi dari Ranting Flemingia macrophylla." al-Kimiya 8, no. 1 (2021): 9–14. http://dx.doi.org/10.15575/ak.v8i1.8711.

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Flemingia macrophylla merupakan tumbuhan perdu yang termasuk keluarga Fabaceae. Senyawa fenolik Flemingia mengandung senyawa flavonoid dan isoflavonoid. Penelitian ini bertujuan untuk menentukan aktivitas sitotoksik senyawa isoflavonoid dari Flemingia macrophylla terhadap sel kanker payudara T47D. Ekstraksi dan isolasi senyawa isoflavonoid menggunakan metanol pada suhu kamar. Dua senyawa isoflavonoid terisoprenilasi, 8-(1.1-dimetil-prop-2-enil) genistein (1) dan osajin (2) telah berhasil dipisahkan dari ranting Flemingia macrophylla. Penentuan struktur senyawa isoflavonoid menggunakan data spe
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Zaprasis, Adrienne, Monika Bleisteiner, Anne Kerres, Tamara Hoffmann, and Erhard Bremer. "Uptake of Amino Acids and Their Metabolic Conversion into the Compatible Solute Proline Confers Osmoprotection to Bacillus subtilis." Applied and Environmental Microbiology 81, no. 1 (2014): 250–59. http://dx.doi.org/10.1128/aem.02797-14.

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ABSTRACTThe data presented here reveal a new facet of the physiological adjustment processes through whichBacillus subtiliscan derive osmostress protection. We found that the import of proteogenic (Glu, Gln, Asp, Asn, and Arg) and of nonproteogenic (Orn and Cit) amino acids and their metabolic conversion into proline enhances growth under otherwise osmotically unfavorable conditions. Osmoprotection by amino acids depends on the functioning of the ProJ-ProA-ProH enzymes, but different entry points into this biosynthetic route are used by different amino acids to finally yield the compatible sol
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Teuschler, Linda K., Richard C. Hertzberg, Anthony McDonald, Yusupha Mahtarr Sey, and Jane Ellen Simmons. "Evaluation of a Proportional Response Addition Approach to Mixture Risk Assessment and Predictive Toxicology Using Data on Four Trihalomethanes from the U.S. EPA’s Multiple-Purpose Design Study." Toxics 12, no. 4 (2024): 240. http://dx.doi.org/10.3390/toxics12040240.

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In this study, proportional response addition (Prop-RA), a model for predicting response from chemical mixture exposure, is demonstrated and evaluated by statistically analyzing data on all possible binary combinations of the four regulated trihalomethanes (THMs). These THMs were the subject of a multipurpose toxicology study specifically designed to evaluate Prop-RA. The experimental design used a set of doses common to all components and mixtures, providing hepatotoxicity data on the four single THMs and the binary combinations. In Prop-RA, the contribution of each component to mixture toxic
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Cen-Pacheco, Francisco, Gerardo Valerio-Alfaro, Dalia Santos-Luna, and José Fernández. "Sclerin, a New Cytotoxic Cyclononapeptide from Annona scleroderma." Molecules 24, no. 3 (2019): 554. http://dx.doi.org/10.3390/molecules24030554.

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A new cytotoxic cyclononapeptide, sclerin, cyclo(–Dab1–Ser2–Tyr3–Gly4–Thr5–Val6–Ala7– Ile8–Pro9–) (1), was isolated from the methanol extract of the seeds of Annona scleroderma, together with the known metabolite, cyclosenegalin A, cyclo(–Pro1–Gly2–Leu3–Ser4–Ala5–Val6–Thr7–) (2). The planar structures for the two compounds were established by comprehensive analysis of NMR and ESI-HRMS data, and the absolute stereochemistry was stablished by Marfey’s method. Compound 1 showed moderate cytotoxic activity against the human prostate carcinoma cell line DU-145 at µM concentration.
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Nolden, Alissa A., John E. McGeary, and John E. Hayes. "Predominant Qualities Evoked by Quinine, Sucrose, and Capsaicin Associate With PROP Bitterness, but not TAS2R38 Genotype." Chemical Senses 45, no. 5 (2020): 383–90. http://dx.doi.org/10.1093/chemse/bjaa028.

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Abstract Genetic variability in the ability to taste thiourea compounds has been studied for 80+ years. Over the last 3 decades, many studies have reported perceived intensity of concentrated propylthiouracil (PROP) associates with greater intensity from a broad range of stimuli, including nonbitter tastants, irritants, and retronasally delivered odorants. Thus, PROP phenotype has become a common measure of individual differences in orosensation. Much, but not all, of the phenotypic variation in PROP bitterness is explained by TAS2R38 polymorphisms. While differences in PROP bitterness are cle
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Miranda-Figueroa, Alain, Carlos Gutiérrez_Aguilar, Manuel González-Ronquillo, et al. "PSX-B-1 Effect of exposure time and dose of effective microorganisms (EM®) on feed in vitro rumen fermentation and digestibility." Journal of Animal Science 99, Supplement_3 (2021): 455–57. http://dx.doi.org/10.1093/jas/skab235.810.

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Abstract The objective was to evaluate the effect of feed inoculation with effective microorganisms (EM®) (mainly containing Lactobacillus spp.,Rhodopseudomona palustrisand Saccharomyces cerevisiae) on rumen fermentation using in vitrogas production technique. We hypothesized that increasing doses and allowing exposure of EM® for up to 48 hours, would improve digestibility and rumen fermentation. The experimental design was a 4×4 completely randomized block design including 4 EM® levels [(0(EM0), 0.5(EM0.5), 1.0 (EM1) and 1.5 (EM1.5) mL EM® / kg DM] and 4 preincubation times [0 (T0), 12(T12),
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Yeomans, Martin R., John Prescott, and Natalie J. Gould. "Acquired hedonic and sensory characteristics of odours: Influence of sweet liker and propylthiouracil taster status." Quarterly Journal of Experimental Psychology 62, no. 8 (2009): 1648–64. http://dx.doi.org/10.1080/17470210802557793.

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Repeated pairings of novel food-related odours with sweet tastes can result in enduring changes in sweetness of the odour alone, but have less consistent effects on odour liking. Variation in ability to taste propylthiouracil (PROP) might account for this, since PROP supertasters (ST) have been reported both to experience stronger sweetness intensity and to be more likely to dislike sweetness than do PROP nontasters (NT). Alternatively, individual differences in liking for sweetness may transfer to sweet-paired odours independently of PROP sensitivity. To explore this, evaluations of sucrose,
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Saum, Stephan H., and Volker Müller. "Salinity-Dependent Switching of Osmolyte Strategies in a Moderately Halophilic Bacterium: Glutamate Induces Proline Biosynthesis in Halobacillus halophilus." Journal of Bacteriology 189, no. 19 (2007): 6968–75. http://dx.doi.org/10.1128/jb.00775-07.

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ABSTRACT The moderately halophilic bacterium Halobacillus halophilus copes with the salinity in its environment by the production of compatible solutes. At intermediate salinities of around 1 M NaCl, cells produce glutamate and glutamine in a chloride-dependent manner (S. H. Saum, J. F. Sydow, P. Palm, F. Pfeiffer, D. Oesterhelt, and V. Müller, J. Bacteriol. 188:6808-6815, 2006). Here, we report that H. halophilus switches its osmolyte strategy and produces proline as the dominant solute at higher salinities (2 to 3 M NaCl). The proline biosynthesis genes proH, proJ, and proA were identified.
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Horner, Jack K. "A Computationally Assisted Reconstruction of an Ontological Argument in Spinoza’s The Ethics." Open Philosophy 2, no. 1 (2019): 211–29. http://dx.doi.org/10.1515/opphil-2019-0012.

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AbstractThe comments accompanying Proposition (Prop.) 11 (“God ... necessarily exists”) in Part I of Spinoza’s The Ethics contain sketches of what appear to be at least three more or less distinct ontological arguments. The first of these is problematic even on its own terms. More is true: even the proposition “God exists” (GE), a consequence of Prop. 11, cannot be derived from the definitions and axioms of Part I (the “DAPI”) of The Ethics; thus, Prop. 11 cannot be derived from the DAPI, either. To prove these claims, I use an automated deduction system (ADS) to show that Prop. 11 is independ
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Alanzi, Abrar, Marianna Velissariou, Manal Abu Al-Melh, Donald Ferguson, and Katerina Kavvadia. "Role of taste perception in white spot lesion formation during orthodontic treatment." Angle Orthodontist 89, no. 4 (2019): 624–29. http://dx.doi.org/10.2319/091918-680.1.

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ABSTRACT Objectives: To investigate the role of individual's taste sensitivity using 6-n-propylthiouracil (PROP) in the development of white spot lesions (WSLs) in adolescent orthodontic patients. Materials and Methods: 44 healthy adolescents, aged 12 to 16 years old, who were in fixed-appliance orthodontic treatment for at least 6 months, consented to participate in this cross-sectional study. Data regarding participants' demographic information, oral hygiene practices, and dietary habits were obtained by a questionnaire. An oral clinical examination was performed to determine the oral hygien
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Keeler, Courtney, Wendy Max, Tingting Yao, Yingning Wang, Xueying Zhang, and Hai-Yen Sung. "Smoking Behavior in Low- and High-Income Adults Immediately Following California Proposition 56 Tobacco Tax Increase." American Journal of Public Health 110, no. 6 (2020): 868–70. http://dx.doi.org/10.2105/ajph.2020.305615.

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Objectives. To compare the association of California Proposition 56 (Prop 56), which increased the cigarette tax by $2 per pack beginning on April 1, 2017, with smoking behavior among low- and high-income adults. Methods. Drawing on a sample of 17 206 low-income and 21 324 high-income adults aged 21 years or older from the 2012 to 2018 California Behavioral Risk Factor Surveillance System data, we explored 2 outcomes: current smoking prevalence and smoking intensity (average number of cigarettes per day among current smokers). For each income group, we estimated a multivariable logistic regres
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Grissom, James B. "Reclassification of English Learners." education policy analysis archives 12 (July 30, 2004): 36. http://dx.doi.org/10.14507/epaa.v12n36.2004.

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Ron Unz, originator of Proposition 227, claimed, prior to the passage of Prop. 227, that the five percent annual reclassification rate of English learners to fluent English proficient indicated bilingual education was a failure. Critics of Prop. 227 have countered that the annual reclassification rate has changed little since the passage of Prop. 227, indicating the new legislation had no effect on reclassification rates. Unfortunately, the annual reclassification rate does not provide a clear indicator of how long it takes students to be reclassified after entering the school system. To bette
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Dianna, Danu Nur. "PENDIDIKAN MULTIKULTURAL DARI PERSPEKTIF H.M. RASJIDI." Profetika: Jurnal Studi Islam 21, no. 1 (2020): 91–98. http://dx.doi.org/10.23917/profetika.v21i1.11651.

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This paper aims to study the concept of religious thought and tolerance according to Prof. H.M. Rasjidi which will be a fundamental discussion in the concept of multicultural education. The methodology in this research is a literature study of books by Prof. H.M. Rasjidi who has a discussion about the concepts of religion and tolerance. The primary source book in this study is "Empat Kuliah Agama Islam" and "Koreksi Terhadap Dr. Harun Nasution dalam Islam Ditinjau dari Berbagai Aspeknya". Prof. H.M. Rasjidi, provides clear boundaries in the theological aspects of how Muslims have the concept o
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Long, Mengfei, Meijuan Xu, Zhenfeng Ma, et al. "Significantly enhancing production of trans-4-hydroxy-l-proline by integrated system engineering in Escherichia coli." Science Advances 6, no. 21 (2020): eaba2383. http://dx.doi.org/10.1126/sciadv.aba2383.

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Trans-4-hydroxy-l-proline is produced by trans-proline-4-hydroxylase with l-proline through glucose fermentation. Here, we designed a thorough “from A to Z” strategy to significantly improve trans-4-hydroxy-l-proline production. Through rare codon selected evolution, Escherichia coli M1 produced 18.2 g L−1l-proline. Metabolically engineered M6 with the deletion of putA, proP, putP, and aceA, and proB mutation focused carbon flux to l-proline and released its feedback inhibition. It produced 15.7 g L−1trans-4-hydroxy-l-proline with 10 g L−1l-proline retained. Furthermore, a tunable circuit base
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Mathur, Poonam, Sarah Kattakuzhy, Laura Nussdorf, et al. "1297. Characteristics for PrEP Uptake, Retention, and Discontinuation: Data From the ANCHOR Study." Open Forum Infectious Diseases 5, suppl_1 (2018): S396. http://dx.doi.org/10.1093/ofid/ofy210.1130.

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Abstract Background People who inject drugs (PWID) have an increased risk for HIV, and HCV infection may foreshadow HIV acquisition in current epidemics. Studies of PWID have demonstrated a desire to obtain HCV treatment; however, use of pre-exposure prophylaxis (PrEP) in this population has not been well studied. Methods The ANCHOR study is an ongoing single-center study evaluating treatment of HCV in PWID. Enrolled patients have chronic HCV, opioid use disorder, and inject opioids. Patients are treated with sofosbuvir/velpatasvir and offered PrEP. Patients complete baseline community health
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Lawal-Adebowale, Okanlade A. "Geospatial and socioeconomic traits encumbering tractorisation of farmland among crop farmers in Ogun State, Nigeria." Journal of Water and Land Development 43, no. 1 (2019): 96–105. http://dx.doi.org/10.2478/jwld-2019-0067.

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AbstractThe objective of this study was to ascertain the socioeconomic and geospatial traits responsible for little or no usage of tractors for land clearing and cultivation by rural farmers in Ogun State, Nigeria. Data were obtained on the study objectives with use of interview guide, in-depth discussion and field observation a randomly selected 247 arable crop farmers. The obtained data were subjected to frequency count and binominal analysis of variance. Results showed factors such as farmers’ inability to afford tractor acquisition and/or hire tractors services (prop = 1.00, p < 0.05) a
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Rendle, D. F., E. J. Glazier, P. M. Cain, and B. E. Connett. "X-Ray Powder Diffraction Data for 2-nitro-l-phenyl-prop-l-ene." Powder Diffraction 4, no. 4 (1989): 231–32. http://dx.doi.org/10.1017/s0885715600013816.

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AbstractX-ray powder diffraction data for the compound 2-nitro-l-phenyl-prop-l-ene, C9H9NO2 are reported. The crystals are orthorhombic and the space group is Pbca[61], with a = 7.576(2), b = 19.452(5), c = 11.269(4)Å, Z = 8 Dx = 1.305, Dm = 1.300(2) g/cm3.
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Putri, Chatarina Natassya, Wafi Dzul Qornain, Fakhirah Bamahri, Gusti Eka Yuliastuti, and Muchamad Kurniawan. "Klasifikasi Jenis Jerawat pada Data Citra Jerawat Wajah Menggunakan Convolutional Neural Network." TIN: Terapan Informatika Nusantara 5, no. 2 (2024): 172–81. http://dx.doi.org/10.47065/tin.v5i2.5231.

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Acne is a condition caused by pilosebaceous inflammation which affects 85% of skin conditions in adolescents and adults. Acne has an impact on the psychological and social health of sufferers. To treat acne, it is necessary to know the right type of acne so that sufferers can treat the type of acne according to how they are treated. This research was carried out to classify the types of acne in facial acne images using the Convolutional Neural Network (CNN) method. Based on previous research, it shows that the use of CNN is considered effective and appropriate in increasing classification accu
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Wolf, Tessa, Wolfgang Greiner, and Peter Stegmaier. "Keine nachhaltige Gesundheitsversorgung ohne Daten." Monitor Versorgungsforschung 2025, no. 01 (2025): 22–25. https://doi.org/10.24945/mvf.01.25.1866-0533.2684.

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In addition to the several hundred quality indicators and key figures in the hospital quality reports, there are now a further 292 "measurable indicators that are specifically tailored to the requirements of the healthcare system" and which are intended to provide "a detailed and measurable picture of the sustainability and performance of the system". The people involved in the NHI Sustainability Index - Tessa Wolf (Head Corporate Affairs AstraZeneca Germany) and Prof Dr Wolfgang Greiner (holder of the Chair of Health Economics and Health Management at Bielefeld University and scientific advis
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Kronick, Jane C. "Alternative Methodologies for the Analysis of Qualitative Data." Czech Sociological Review 33, no. 1 (1997): 57–68. http://dx.doi.org/10.13060/00380288.1997.33.1.10.

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Brako, Daniel Kofi. "The props propelleth the performance: Prop elements in the celebration of Edina Bakatue festival." Journal of Innovations in Science and Technology 1, no. 1 (2023): 17–38. http://dx.doi.org/10.60129/jinces.v1i1.00323.

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The Edina Bakatue festival is one of the traditional festivals celebrated in Ghana by the people of Elmina in the Central Region. The celebration of this festival serves as an avenue for showcasing the rich cultural heritage of the people. For this celebration, props feature prominently. Although there is a plethora of studies on festivals in Ghana, there is a dearth of research on the significance of prop elements in traditional Ghanaian festivals. Engaging a qualitative approach to research, employing the purposive sampling technique to select twelve (12) participants, and relying on multipl
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Joyner, M. J., B. J. Freund, S. M. Jilka, et al. "Effects of beta-blockade on exercise capacity of trained and untrained men: a hemodynamic comparison." Journal of Applied Physiology 60, no. 4 (1986): 1429–34. http://dx.doi.org/10.1152/jappl.1986.60.4.1429.

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To study the effects of cardiovascular fitness on hemodynamic responses to exercise during beta-adrenergic blockade (BAB), submaximal [60% of maximum O2 uptake (VO2max)] and maximal treadmill exercise data were collected in 11 trained (T, VO2max 63.3 ml X kg-1 X min-1, 26.8 yr) and 11 untrained (UT, VO2max 44.5 ml X kg-1 X min-1, 25.0 yr) male subjects. Subjects completed two maximal control tests followed by a randomized, double-blind series of maximal tests after 1-wk treatments with placebo (PLAC), propranolol (PROP, 160 mg/day, beta 1- and beta 2-blockade), and atenolol (ATEN, 100 mg/day,
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Baliellas, Deborah E. M., Marcelo P. Barros, Cristina V. Vardaris, et al. "Propentofylline Improves Thiol-Based Antioxidant Defenses and Limits Lipid Peroxidation following Gliotoxic Injury in the Rat Brainstem." Biomedicines 11, no. 6 (2023): 1652. http://dx.doi.org/10.3390/biomedicines11061652.

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Propentofylline (PROP) is a methylated xanthine compound that diminishes the activation of microglial cells and astrocytes, which are neuronal cells strongly associated with many neurodegenerative diseases. Based on previously observed remyelination and neuroprotective effects, PROP has also been proposed to increment antioxidant defenses and to prevent oxidative damage in neural tissues. Since most neurodegenerative processes have free radicals as molecular pathological agents, the aim of this study was to evaluate the antioxidant effects of 12.5 mg·kg−1·day−1 PROP in plasma and the brainstem
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Triola, Seres, Andika Saputra, Haves Ashan, and Febianne Eldrian. "Profil Pasien Serumen Prop di RSI Siti Rahmah pada Tahun 2022." Scientific Journal 4, no. 4 (2025): 314–20. https://doi.org/10.56260/sciena.v4i4.253.

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Latar Belakang: Serumen prop adalah penumpukan kotoran telinga yang mengeras yang dapat menyebabkan berbagai gejala seperti nyeri, vertigo, tinnitus, dan rasa penuh pada telinga. Kondisi ini dapat mengganggu fungsi pendengaran dan memerlukan penanganan yang tepat untuk mencegah komplikasi. Individu lanjut usia memiliki risiko lebih tinggi akibat perubahan fisiologi saluran telinga, seperti kekeringan dan menurunnya mekanisme pembersihan alami. Tujuan: Penelitian ini bertujuan untuk menganalisis profil pasien serumen prop di RSI Siti Rahmah pada tahun 2022 berdasarkan jenis kelamin, usia, manif
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Fazly, Riazulhaq, Nafla Raees, Muhammad Qaiser Shafi, Shakir Iqbal, and Muhammad Javid Nawaz. "Impact of project planning and project risk management on project success: moderating role of project managers’ competencies in the construction sector in Afghanistan." Journal of Humanities, Social and Management Sciences (JHSMS) 5, no. 2 (2024): 1–20. http://dx.doi.org/10.47264/idea.jhsms/5.2.1.

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This research examines the impact of project planning (ProP) and project risk management (RisM) on project success (ProS) while maintaining project managers’ competencies (PMC) as moderators using resource-based view theory concepts. This research addresses the gap in how ProP and RisM lead to ProS in the presence of a PMC as a moderator in construction-based private organisations. Utilising a convenience sampling technique, data were collected from 249 participants working in construction-based organizations across major cities in Afghanistan. Data were analysed using Smart-PLS and SPSS softw
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Nolden, Alissa A., Maik Behrens, John E. McGeary, Wolfgang Meyerhof, and John E. Hayes. "Differential Activation of TAS2R4 May Recover Ability to Taste Propylthiouracil for Some TAS2R38 AVI Homozygotes." Nutrients 16, no. 9 (2024): 1357. http://dx.doi.org/10.3390/nu16091357.

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Bitterness from phenylthiocarbamide and 6-n-propylthiouracil (PROP) varies with polymorphisms in the TAS2R38 gene. Three SNPs form two common (AVI, PAV) and four rare haplotypes (AAI, AAV, PVI, and PAI). AVI homozygotes exhibit higher detection thresholds and lower suprathreshold bitterness for PROP compared to PAV homozygotes and heterozygotes, and these differences may influence alcohol and vegetable intake. Within a diplotype, substantial variation in suprathreshold bitterness persists, and some AVI homozygotes report moderate bitterness at high concentrations. A second receptor encoded by
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Melis, Melania, Giorgia Sollai, Mariano Mastinu, et al. "Electrophysiological Responses from the Human Tongue to the Six Taste Qualities and Their Relationships with PROP Taster Status." Nutrients 12, no. 7 (2020): 2017. http://dx.doi.org/10.3390/nu12072017.

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Taste buds containing receptor cells that primarily detect one taste quality provide the basis for discrimination across taste qualities. The molecular receptor multiplicity and the interactions occurring between bud cells encode information about the chemical identity, nutritional value, and potential toxicity of stimuli before transmitting signals to the hindbrain. PROP (6-n-propylthiouracil) tasting is widely considered a marker for individual variations of taste perception, dietary preferences, and health. However, controversial data have been reported. We present measures of the periphera
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Hazram, Nurul Ain, Mashitah Abdul Mutalib, Nur Al-Farhain Kamaruzaman, and Nur Aina Abdulah. "Pemberian Ubat Pre-Exposure Prophylaxis (PrEP) Kepada Golongan LGBT: Analisis Dari Perspektif Syariah." Journal of Muwafaqat 6, no. 2 (2023): 103–19. http://dx.doi.org/10.53840/muwafaqat.v6i2.161.

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Pre-Exposure Prophylaxis (PrEP) adalah sejenis ubat yang digunakan untuk mereka yang berisiko menerima jangkitan virus ‘Human Immunodeficiency Virus’ (HIV), yang dikenali sebagai penyakit ‘Sindrom Kurang Daya Tahan Melawan Penyakit’ (AIDS). Melalui ujian klinikal yang telah dijalankan, penggunaan PrEP telah terbukti dapat mengurangkan risiko jangkitan HIV/ AIDS. Pada penghujung tahun 2022, Menteri Kesihatan pada waktu itu telah mengumumkan akan menjalankan satu projek rintis penggunaan ubat PrEP di beberapa hospital kerajaan untuk menguji keberkesanannya sebelum ubat tersebut diperakukan oleh
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Garcia de la Nava, J., S. van Hijum, and O. Trelles. "PreP: gene expression data pre-processing." Bioinformatics 19, no. 17 (2003): 2328–29. http://dx.doi.org/10.1093/bioinformatics/btg318.

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Brown, T., and S. J. James. "Process design data for prok chilling." International Journal of Refrigeration 15, no. 5 (1992): 281–89. http://dx.doi.org/10.1016/0140-7007(92)90043-t.

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Canady, Valerie A. "Calif.'s Prop. 63 still lacks accountability, common data-collecting system." Mental Health Weekly 26, no. 23 (2016): 1–3. http://dx.doi.org/10.1002/mhw.30635.

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Musoke, Lewis, Kristen A. Allen, Kaylee Bray, et al. "849. Impact of a Combined Education and Data Driven Intervention on PrEP Uptake at the Veterans Health Administration." Open Forum Infectious Diseases 8, Supplement_1 (2021): S514—S515. http://dx.doi.org/10.1093/ofid/ofab466.1044.

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Abstract Background Despite proven efficacy, uptake of pre-exposure prophylaxis (PrEP) for HIV prevention in the US remains suboptimal. Whether electronic medical record (EMR) driven data tools increase PrEP uptake is unknown. Our study sought to understand the impact of education and an EMR data tool to increase PrEP uptake at the Veterans Northeast Ohio Healthcare System (VANEOHS). Methods Using EMR data we identified persons at the VANEOHS with a diagnosis of bacterial Sexually Transmitted Illness (STI) as defined by a positive syphilis, gonorrhea or chlamydia test in the past 6 months. Beg
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Mehranfard, Danial, Gabriela Perez, Andres Rodriguez, et al. "Alterations in Gene Expression of Renin-Angiotensin System Components and Related Proteins in Colorectal Cancer." Journal of the Renin-Angiotensin-Aldosterone System 2021 (July 5, 2021): 1–17. http://dx.doi.org/10.1155/2021/9987115.

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Hypothesis/Introduction. Recent studies suggest involvement of the renin-angiotensin system (RAS) in cancers, including colorectal cancer (CRC). This study focuses on the association of genes encoding 17 proteins related to the RAS within a Japanese male CRC population. Materials and Methods. Quantitative expression of the RNA of these 17 genes in normal and cancerous tissues obtained using chip arrays from the public functional genomics data repository, Gene Expression Omnibus (GEO) application, was compared statistically. Results. Expression of four genes, AGT (angiotensinogen), ENPEP (amino
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Yousaf, Neeta Y., and Beverly J. Tepper. "The Effects of Cranberry Polyphenol Extract (CPE) Supplementation on Astringency and Flavor Perception as a Function of PROP Taster Status and Other Individual Factors." International Journal of Environmental Research and Public Health 19, no. 19 (2022): 11995. http://dx.doi.org/10.3390/ijerph191911995.

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This study investigated whether PROP (6-n-propylthiouracil) taster status and other individual factors (gender, ethnicity, BMI, and age) are markers of variation in perceptions of astringency and other flavor attributes. Participants (n = 125) evaluated cranberry juice cocktail samples (CJC) supplemented with cranberry-derived polyphenol extract (CPE, added at 0, 0.3, 0.5 and 0.75 g/L), as well as control samples, unsweetened cranberry juice (CJ) and an aqueous solution of 0.75 g/L CPE. Subjects evaluated samples for key sensory attributes and overall liking using a 15 cm line scale. The data
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Rizal, Rahmat, Haji Aripin, and I. Made Joni. "Solar-powered electric car: validity and effectivity of prop in energy conversion learning." Journal of Education and Learning (EduLearn) 18, no. 3 (2024): 699–707. http://dx.doi.org/10.11591/edulearn.v18i3.21720.

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The research aimed to describe the development of solar electric cars as a prop in energy conversion learning using the analyze, design, develop, implement, and evaluate (ADDIE) model and to ascertain the effectiveness of an electric car as a prop in energy conversion learning. Utilization of prop in the learning process is one way to support the development of knowledge, skills, and basic needs for delivering material, concepts, and physics information. This research is a descriptive study involving media and pedagogical experts and 40 students of the university in Tasikmalaya. Data collectio
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Rahmat, Rizal, Aripin Haji, and Made Joni I. "Solar-powered electric car: validity and effectivity of prop in energy conversion learning." Journal of Education and Learning (EduLearn) 18, no. 3 (2024): 699–707. https://doi.org/10.11591/edulearn.v18i3.21720.

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The research aimed to describe the development of solar electric cars as a prop in energy conversion learning using the analyze, design, develop, implement, and evaluate (ADDIE) model and to ascertain the effectiveness of an electric car as a prop in energy conversion learning. Utilization of prop in the learning process is one way to support the development of knowledge, skills, and basic needs for delivering material, concepts, and physics information. This research is a descriptive study involving media and pedagogical experts and 40 students of the university in Tasikmalaya. Data collectio
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Isnaeni, Rizka Nur, Aditya Kusumawati, and Novia Handayani. "Implementasi Layanan Profilaksis Pra Pajanan (PrEP) Oral (Studi Kualitatif 2 Puskesmas di Kota Semarang)." Jurnal Kesehatan 15, no. 2 (2024): 207–14. http://dx.doi.org/10.26630/jk.v15i2.4421.

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Pemberlakuan uji coba program Pre-Exposure Prophylaxis (PrEP) sebagai program pencegahan HIV di Kota Semarang belum berjalan optimal. Petugas kesehatan yang memiliki peran penting sebagai pelaksana program masih mengalami berbagai kendala, baik hambatan secara teknis maupun hambatan dalam pencatatan dan pelaporan yang cukup rumit. Program yang sudah berjalan hampir 3 tahun ini sangat penting untuk dilakukan kajian yang lebih mendalam, khususnya pada petugas kesehatan yang berperan langsung dalam memberikan layanan PrEP. Pengumpulan data secara deskriptif kualitatif yang dilakukan dengan wawanc
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Christianti, Ari. "VOLATILITY SHOCK PERSISTENCE IN INVESTMENT DECISION MAKING: A COMPARISON BETWEEN THE CONSUMER GOODS AND PROPERTY-REAL ESTATE SECTORS OF THE INDONESIAN CAPITAL MARKET." Journal of Indonesian Economy and Business 33, no. 2 (2018): 112. http://dx.doi.org/10.22146/jieb.23225.

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Research about volatility shock persistence is very important, since it could reflect the risks that can be used to estimate the fluctuations of stock returns in the future. This paper investigates a comparison of the volatility shock persistence sectoral indexes between the consumer goods (CONS) and property-real estate (PROP) sectors, using a single index model analyzed using GARCH (Generalized Autoregressive Conditional Heteroscedasticity) and I-GARCH (Integrated-Generalized Autoregressive Conditional Heteroscedasticity). By using index return data from January 2010-December 2015, the resea
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LAVRINČÍK, Jan. "DYNAMIC INFORMATION SYSTEMS TO MANAGE DATA SCHOOLS." Journal of Technology and Information 2, no. 1 (2010): 39–43. http://dx.doi.org/10.5507/jtie.2010.007.

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BUREŠ, R. "Microbiological databases and databanks for biotechnology." Kvasny Prumysl 34, no. 11 (1988): 331–33. http://dx.doi.org/10.18832/kp1988048.

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Fajar Ramadianto and Miswanti. "METODE KOMUNIKASI DAKWAH PROF. DR. H. M. RASJIDI TENTANG ALIRAN KEBATINAN DALAM BUKU ISLAM DAN KEBATINAN KARYA H. M. RASJIDI." JOISCOM (Journal of Islamic Communication) 5, no. 1 (2024): 28–37. http://dx.doi.org/10.36085/joiscom.v5i1.6365.

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ABSTRAK Di Indonesia pada saat ini mayoritas masyarakat menganut agama Islam, tetapi dengan begitu masih banyak sekali yang belum melaksanakan ajaran agama Islam sesuai dengan Syari’at menurut Al-Quran dan Hadits baik yang tinggal di perdesaan maupun diperkotaan terutama yang masyarakat awam. Tujuan dari penelitian ini yaitu untuk mengetahui bagaimana metode komunikasi dakwah yang dilakukan oleh Prof Dr H M Rasjidi tentang aliran kebatinan dalam buku Islam dan Kebatinan. Penelitian ini merupakan jenis penelitian kepustakaan (Library Research) dengan Teknik pengumpulan data menggunakan data pri
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Ilham Setio Wibowo, Denny Kurniawan, Sastya Putri, Tri Endang Yulianti, and Harits Kurniawan. "Kinerja Keuangan BPR Syariah Ditinjau dari Aspek Pertumbuhan Ekonomi di Provinsi Lampung." SANTRI : Jurnal Ekonomi dan Keuangan Islam 2, no. 5 (2024): 83–94. http://dx.doi.org/10.61132/santri.v2i5.897.

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This study aims to use financial indicators to determine the effect of regional gross domestic product on the performance of Sharia BPR in Lampung. This survey method uses a quantitative descriptive survey whether the performance of the Lampung BPR SYARIAH will be influenced by Lampung's economic growth between January 2020 to December 2021. The population and sample are all BPR SYARIAH registered with the Financial Services Authority (OJK), and there are 11 BPR SYARIAH in the Lampung study area. So it can be said that the influence of KAP (X1) NPF (X2) ROA (X3) BOPO (X4) FDR (X5) CASH RATIO (
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