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Thematische Bibliographien / Drug delivery to brain / Dissertationen

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Dissertationen zum Thema „Drug delivery to brain“

Autor: Grafiati

Veröffentlicht am 28. Juni 2021

Zuletzt aktualisiert am 29. Juli 2025

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1

Boltman, Taahirah. "Liposomal drug delivery to brain cancer cells." University of the Western Cape, 2015. http://hdl.handle.net/11394/4706.

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Master of Science (Nanoscience)<br>Neuroblastomas (NBs) are the most common solid extra-cranial tumours diagnosed in childhood and characterized by a high risk of tumour relapse. Like in other tumour types, there are major concerns about the specificity and safety of available drugs used for the treatment of NBs, especially because of potential damage to the developing brain. Many plant-derived bioactive compounds have proved effective for cancer treatment but are not delivered to tumour sites in sufficient amounts due to compromised tumour vasculature characterized by leaky capillary walls. B

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Huynh, Grace. "Convection administered drug delivery to the brain." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3251934.

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3

Lungare, Shital. "Development of novel delivery systems for nose-to-brain drug delivery." Thesis, Aston University, 2017. http://publications.aston.ac.uk/37491/.

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The blood brain barrier (BBB) poses a significant hurdle to brain drug delivery. However, the location of the olfactory mucosa, within the nasal cavity, is a viable target site for direct nose-to-brain (N2B) delivery, thereby bypassing the BBB. To exploit this target site innovative nasal formulations are required for targeting and increasing residency within the olfactory mucosa. We developed and characterised three formulation systems for N2B delivery, (i) thermoresponsive mucoadhesion nasal gels sprays; (ii) mesoporous silica nanoparticles and (iii) nasal pMDI devices. We developed an optim

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4

Charlton, Stuart Thomas. "Drug delivery to the brain via intranasal administration." Thesis, University of Nottingham, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275962.

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5

Ibegbu, Madu Daniel. "Functionalised dextran nanoparticles for drug delivery to the brain." Thesis, University of Portsmouth, 2015. https://researchportal.port.ac.uk/portal/en/theses/functionalised-dextran-nanoparticles-for-drug-delivery-to-the-brain(c2da4093-315e-4647-90e1-4340acf2b8bd).html.

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Towards the development of drug carriers that are capable of crossing the Blood Brain Barrier, the techniques of emulsion polymerisation and nanoprecipitation have been utilised to produce nanoparticulate carriers from a systematic series of alkylglyceryl dextrans (of two different average molecular weights, 6 kDa and 100 kDa) that had been functionalised with ethyl and butyl cyanoacrylates. Also, zero length grafting of polylactic acid to butyl, octyl and hexadecylglyceryl dextrans has allowed the preparation of polylactic acid-functionalised nanoparticles. All materials and derived nanoparti

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Bin, Bostanudin Mohammad Fauzi. "Butylglyceryl-modified polysaccharide nanoparticles for drug delivery to the brain." Thesis, University of Portsmouth, 2016. https://researchportal.port.ac.uk/portal/en/theses/butylglycerylmodified-polysaccharide-nanoparticles-for-drug-delivery-to-the-brain(a91de9ba-3070-40a4-bf66-400f4d63027d).html.

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The limited access to the brain of a large number of therapeutic actives due to the presence of the blood-brain barrier (BBB) has led to intensive research toward the development of nanotechnology-based approaches. Polysaccharides such as chitosan, guar gum, pectin and pullulan have been selected as starting materials for this study due to their biocompatibility, biodegradability, good drug carrier properties, and ease of chemical modification with short chain alkylglycerol-like moieties (expected to enhance drug permeability through the BBB). A series of butylglyceryl-modified polysaccharides

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Ong, Qunya. "Local drug delivery for treatment of brain tumor associated edema." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/95865.

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Thesis: Ph. D., Harvard-MIT Program in Health Sciences and Technology, 2014.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 115-127).<br>Brain tumor associated edema, a common feature of malignant brain neoplasms, is a significant cause of morbidity from brain tumor. Systemic administration of corticosteroids, the standard of care, is highly effective but can introduce serious systemic complications. Agents that inhibit the vascular endothelial growth factor (VEGF) pathway, such as cediranib, are promising alternatives, but are also associated with syste

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Sharma, Gitanjali. "Dual Modified Liposomes for Drug and Gene Delivery to Brain." Diss., North Dakota State University, 2014. https://hdl.handle.net/10365/27310.

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The overall goal of our research was to design a vector for efficient delivery of therapeutic genes/drugs to brain. Specifically, this research work was focused on designing PEGylated liposomes surface modified with the receptor targeting protein, transferrin and cell penetrating peptides (CPPs) for targeting and improving the delivery of desired therapeutic agent to brain. Various CPPs including poly-L-arginine, TAT, Penetratin and Mastoparan were investigated for their influence on transport of transferrin receptor targeted liposomes across brain endothelial cells. The dual-modified liposome

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Toman, Petr. "Nanoparticles from alkylglyceryl-modified polysaccharides for drug delivery to the brain." Thesis, University of Portsmouth, 2012. https://researchportal.port.ac.uk/portal/en/theses/nanoparticles-from-alkylglycerylmodified-polysaccharides-for-drug-delivery-to-the-brain(7c977729-1e45-45d9-b826-f1729a8d784c).html.

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The loading of therapeutic actives into polymeric nanoparticles represents one of the approaches towards drug transport through the blood-brain barrier – the main obstacle to drug delivery into the central nervous system. The non-toxic, biocompatible and biodegradable polysaccharides chitosan and dextran were modified with permeation-enhancing alkylglyceryl pendant chains through reaction with epoxide precursors. The modified polysaccharides were characterised by spectroscopic methods (1H-, 13C-NMR and FT-IR). These polysaccharides were further formulated into nanoparticles using three methods

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Molnár, Éva. "Modified-chitosan nanoparticles for drug delivery through the blood-brain barrier." Thesis, University of Portsmouth, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.494005.

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Towards the development of nanoparticulate carriers that cross the blood-brain barrier, a series of alkylglyceryl-modified chitosans with systematically varied degrees of grafting were prepared through synthetic steps that involved the protection of amino moieties via the formation of phthaloyl chitosan. The modified chitosans were formulated into nanoparticle using an ionic gelation technique employing sodium tripolyphosphate. Polymers were characterised by FTER, ¹H- and ¹³C-NMR, and by viscometry and GPC techniques. The size distribution profiles of nanoparticles were determined by dynamic l

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Safdar, Shahana. "Peptide-targeted nitric oxide delivery for the treatment of glioblatoma multiforme." Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/45797.

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Glioblastoma multiforme (GBM) is the most common malignant central nervous system tumor. The ability of glioma cells to rapidly disperse and invade healthy brain tissue, coupled with their high resistance to chemotherapy and radiation have resulted in extremely poor prognoses among patients. In recent years, nitric oxide (NO) has been discovered to play a ubiquitous of role in human physiology and studies have shown that, at sufficient concentrations, NO is able to induce apoptosis as well as chemosensitization in tumor cells. This thesis discusses the synthesis and characterization of targete

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Krishan, Mansi. "Enhanced Intranasal Delivery of Gemcitabine to the Central Nervous System." University of Cincinnati / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1384850749.

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13

Di, Mauro Primiano Pio. "Development of novel and multifunctional polymeric nanoparticles for brain targeted drug delivery." Doctoral thesis, Universitat Ramon Llull, 2015. http://hdl.handle.net/10803/285236.

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Controlled release systems have become an innovative technique to treat diseases like cancer by the targeted delivery to individual cells and tissues. There is an urgent need to achieve efficacious and safe delivery with minimal nonspecific uptake by healthy tissues. Among the polymer-based nanoparticulate systems for drug delivery, nanoparticles (NPs) have represented a promising opportunity as delivery system due to their degradation in water-soluble compounds that enter the normal metabolic pathways of the organism and their capacity to modify pharmacokinetics and the drug tissue distributi

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CAMBIANICA, ILARIA NADIA. "In vitro blood brain barrier models as a screening tool for brain targeted nanobased drug delivery systems." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2012. http://hdl.handle.net/10281/39834.

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The blood brain barrier (BBB) is a selective biological barrier located at the brain capillaries, that protects the central nervous system (CNS) by monitoring exchanges between blood and brain. The BBB controls and regulates the composition of the CNS environment and it still constitutes the main obstacle for drug delivery to the brain (Weiss N. et al., 2009). The significant scientific and industrial interest in the physiology and pathology of the BBB led to the development of vast number of in vitro BBB models. Even though no “ideal” model exists yet, some of the currently available ones

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Guduru, Rakesh. "Bionano Electronics: Magneto-Electric Nanoparticles for Drug Delivery, Brain Stimulation and Imaging Applications." FIU Digital Commons, 2013. http://digitalcommons.fiu.edu/etd/979.

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Nanoparticles are often considered as efficient drug delivery vehicles for precisely dispensing the therapeutic payloads specifically to the diseased sites in the patient’s body, thereby minimizing the toxic side effects of the payloads on the healthy tissue. However, the fundamental physics that underlies the nanoparticles’ intrinsic interaction with the surrounding cells is inadequately elucidated. The ability of the nanoparticles to precisely control the release of its payloads externally (on-demand) without depending on the physiological conditions of the target sites has the potential to

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Meng, Weina. "Evaluation of a nanoparticle drug delivery vehicle in medulloblastoma and organotypic brain cell cultures." Thesis, University of Nottingham, 2006. http://eprints.nottingham.ac.uk/13933/.

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It has been widely reported that cell culture dimension and microenvironment influence cell proliferation, differentiation, and gene expression, which lead to different interactions between drug delivery systems and cells. The development in evaluation of drug delivery systems has reached the stage where investigations are now concentrating on intracellular uptake and subcellular localization of drug delivery systems.This thesis investigates the use of three-dimensional (3-D) tissue culture models to study how nanoparticles (NPs) may behave in vivo. Poly (glycerol-adipate) (PGA) NPs can degrad

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Varanasi, Ramya. "Advancing in-vitro blood-brain barrier models using lipid-based nanoparticles as a strategy for drug delivery." Thesis, The University of Sydney, 2020. https://hdl.handle.net/2123/25558.

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Introduction: The survival rate of neurological diseases such as brain cancer has remained poor at 1% over the last 30 years despite improvements in technology and novel medicines entering the market. The key obstacle in the treatment of any neurological disease is the blood brain barrier (BBB), a restrictive barrier which ensures the homeostasis of the central nervous system. Developments in lipid-based nanoparticles have presented the opportunity to deliver medicine across the BBB due to their size and ability to tune the ideal properties required to cross. By using human physio-mimicking mo

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Agarwal, Abhiruchi. "Nanocarrier mediated therapies for the gliomas of the brain." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/39468.

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Existing methods of treating glioma are not effective for eradicating the disease. Therefore, new and innovative methods of treatment alone or in combination with existing therapies are necessary. Delivery of therapeutic agents through delivery carriers such as liposomes diminishes the harmful effects of the agent in healthy tissues and allows increased accumulation in the tumor. In addition, targeted chemotherapy using liposomes provides the opportunity for further increase in drug accumulation in tumor. However, the current targeting strategies suffer accelerated plasma clearance and are not

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Hashmi, Sumaiya F. "A DNA Computer for Glioblastoma Multiforme Diagnosis and Drug Delivery." Scholarship @ Claremont, 2013. http://scholarship.claremont.edu/cmc_theses/799.

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Glioblastoma multiforme (GBM) is a debilitating malignant brain tumor with expected patient survival of less than a year and limited responsiveness to most treatments, often requiring biopsy for diagnosis and invasive surgery for treatment. We propose a DNA computer system, consisting of input, computation, and output components, for diagnosis and treatment. The input component will detect the presence of three GBM biomarkers: vascular endothelial growth factor (VEGF), caveolin-1α (CAV), and B2 receptors. The computation component will include indicator segments for each of these genes, and en

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Aryal, Muna. "Transient disruption of vascular barriers using focused ultrasound and microbubbles for targeted drug delivery in the brain." Thesis, Boston College, 2014. http://hdl.handle.net/2345/bc-ir:104127.

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Thesis advisor: Cyril P. Opeil<br>The physiology of the vasculature in the central nervous system (CNS) which includes the blood-brain-barrier (BBB) and other factors, prevents the transport of most anticancer agents to the brain and restricts delivery to infiltrating brain tumors. The heterogeneous vascular permeability in tumor vessels (blood-tumor barrier; BTB), along with several other factors, creates additional hurdles for drug treatment of brain tumors. Different methods have been used to bypass the BBB/BTB, but they have their own limitations such as being invasive, non-targeted or req

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Spencer, Kevin C. (Keven Collen). "A biocompatible, local drug delivery platform for the chronic treatment of neurological disorders of the brain." Thesis, Massachusetts Institute of Technology, 2017. http://hdl.handle.net/1721.1/109685.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Materials Science and Engineering, 2017.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 148-158).<br>Many neurological disorders are now classified as circuit disorders, in which the underlying pathology arises from a failure in dynamic communication between anatomically distinct regions of the brain. Systemic therapies are often not effective due to their untargeted nature. The injectrode is a multifunctional probe designed to treat neurological disorders through targeted chemical and

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Giesen, Beatriz [Verfasser], and Ulf Dietrich [Gutachter] Kahlert. "Gold Nanoparticles as Drug Delivery Systems for Brain Cancer Therapy / Beatriz Giesen ; Gutachter: Ulf Dietrich Kahlert." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2021. http://d-nb.info/1237883814/34.

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CORRIAS, FRANCESCO. "Nanocarriers for drug targeting and improved bioavailability." Doctoral thesis, Università degli Studi di Cagliari, 2014. http://hdl.handle.net/11584/266439.

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This PhD thesis debates, mostly, on two main topics: - Drug delivery to brain - Nanosuspensions for different applications The objective of the first topic was the development of liposomes to which anti-TfR-monoclonal antibodies (Ox26) or lactoferrin was bounded to transport the selective NK3 receptor agonist senktide to CNS across the BBB. NK3 receptors are widely expressed in the CNS and their stimulation by senktide (ICV) increase extracellular DA. Liposomes were prepared using the film hydration method. In vivo microdialysis studies were performed to estimate the responsiveness of NAc s

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Salam, Al-Maliki Shanta Taher. "Nose to Brain Delivery of Antiepileptic Drugs Using Nanoemulsions." University of Toledo Health Science Campus / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=mco1449771501.

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Regberg, Jakob. "Cell-penetrating peptide based nanocomplexes for oligonucleotide delivery." Doctoral thesis, Stockholms universitet, Institutionen för neurokemi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-133794.

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Oligonucleotide-based drugs hold great promise for the treatment of many types of diseases, ranging from genetic disorders to viral infections and cancer. The problem is that efficient delivery across the cell membrane is required for oligonucleotides to have their desired effect. Cell-penetrating peptides (CPPs) provide a solution to this problem. CPPs are capable of transporting cargoes such as drugs or nucleic acids for gene therapy into the cell, either by covalent conjugation to the cargo or by non-covalent complex formation. This thesis is focused on the development of a class of peptide

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Dearborn, Kristina Ok-Hee. "The Characterization of Non-Ionic Surfactant Vesicles: A Release Rate Study for Drug Delivery." [Tampa, Fla] : University of South Florida, 2006. http://purl.fcla.edu/usf/dc/et/SFE0001493.

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Mistry, Alpesh. "The development and application of biological models for evaluation of direct nose-to-brain drug delivery systems." Thesis, University of Nottingham, 2009. http://eprints.nottingham.ac.uk/10654/.

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The olfactory neuroepithelium is the only part of the central nervous system that is exposed directly to the external environment. Therefore, it is the only non-invasive drug delivery route to the brain. Surface modification of PS nanoparticles with chitosan C-PS), polysorbate 80 (P80-PS) and polysorbate 80+FCS (P80-FCS-PS) changed the toxicity and distribution of these nanoparticles in olfactory mucosae. In addition, a reduction in nanoparticle diameter from 200nm to 20nm increased nanoparticle mucosal penetration and possibly also their cellular toxicity. In vitro vertical Franz diffusion ch

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Pawar, Shilpa. "The design and evaluation of a targeted nanoparticulate drug delivery system for the treatment of brain cancer." Thesis, University of Central Lancashire, 2018. http://clok.uclan.ac.uk/25463/.

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Daas, Mohammad. "The development of a drug delivery system using brain endothelial non-antibody binding domains as transport carriers." Thesis, Open University, 2018. http://oro.open.ac.uk/55108/.

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The highly specialised brain capillary endothelial cells (BCEC) that constitute the blood brain barrier (BBB) exhibit high resilience to the penetration of xenobiotic and biologic therapeutics, making drug delivery to the central nervous system (CNS) a challenging feat. Endogenous BCEC receptors such as transferrin receptor (TfR) have been proposed as exploitable targets for therapeutic payload transport into the CNS, and have been successfully targeted using monoclonal antibodies to deliver therapeutic molecules into the brains of rodents and non-human primates via receptor mediated transcyto

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Shukla, Anshu. "A Model for Studying Vasogenic Brain Edema." VCU Scholars Compass, 2006. http://hdl.handle.net/10156/1690.

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31

Bonakdar, Mohammad. "Microdevices for Investigating Pulsed Electric Fields-Mediated Therapies at Cellular and Tissue Level." Diss., Virginia Tech, 2016. http://hdl.handle.net/10919/81384.

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Recent attempts to investigate living systems from a biophysical point of view has opened new windows for development of new diagnostic methods and therapies. Pulsed electric fields (PEFs) are a new class of therapies that take advantage of biophysical properties and have proven to be effective in drug delivery and treating several disorders including tumors. While animal models are commonly being used for development of new therapies, the high cost and complexity of these models along with the difficulties to control the electric field in the animal tissue are some of the obstacles toward the

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Sánchez, Purrà Maria. "Development of novel vesicle-like nanocarriers for targeted drug delivery." Doctoral thesis, Universitat Ramon Llull, 2015. http://hdl.handle.net/10803/288318.

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Les dificultats existents en l’administració de certs fàrmacs, que es tradueix en una considerable reducció de la seva eficàcia terapèutica, ha portat a l’exploració d’un nou camp en la recerca de fàrmacs, l’ús de polímers per a transportar fàrmacs. Aquests polímers es presenten com a vehicles transportadors que aporten protecció al fàrmac, evitant la seva degradació, i permeten la seva distribució dirigida fins la diana terapèutica, disminuint així els efectes secundaris. Una combinació adequada del polímer transportador amb el fàrmac, permet l’alliberament d’aquest en el teixit on ha de dese

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Jain, Anjana. "Delivery of Cdc42, Rac1, and Brain-derived Neurotrophic Factor to Promote Axonal Outgrowth After Spinal Cord Injury." Diss., Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/16210.

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Injury severs the axons in the spinal cord causing permanent functional loss. After injury, a series of events occur around the lesion site, including the deposition of growth cone inhibitory astroglial scar tissue containing chondroitin sulfate proteoglycan (CSPG)- rich regions. It is important to encourage axons to extend through these inhibitory regions for regeneration to occur. The work presented in this dissertation investigates the effect of three proteins, constitutively active (CA)-Cdc42, CA-Rac1, and brain-derived neurotrophic factor (BDNF) on axonal outgrowth through CSPGs-rich i

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Fuchs, Ferdinand Christian. "Sugar conjugates of 3-hydroxy-4-pyridinones : synthesis and investigations into their potential for drug delivery to the brain." Thesis, King's College London (University of London), 2015. http://kclpure.kcl.ac.uk/portal/en/theses/sugar-conjugates-of-3hydroxy4pyridinones(f2b6e057-2a29-4895-a84e-3b42a50968ed).html.

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Parkinson’s disease is the second most common neurodegenerative disease after Alzheimer’s disease, with an incidence of 8-18 cases per 100,000 per year and currently about 125,000 cases in the UK. While lifestyle and genetic risk factors for Parkinson’s disease have been identified, the aetiology remains unclear. The current treatment options are limited to the management of symptoms. Iron is misdistributed and accumulates in the affected brain regions (particularly the substantia nigra) as the disease progresses. Iron chelation has been identified as a treatment that slows down disease progre

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Sonawane, Amit. "Evaluation of novel efflux transport inhibitor for the improvement of drug delivery through epithelial cell monolayer." Thesis, University of Bradford, 2015. http://hdl.handle.net/10454/14424.

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Blood-brain barrier (BBB) is a unique membranous barrier, which segregates brain from the circulating blood. It works as a physical and metabolic barrier between the central nervous system (CNS) and periphery. In mammals, endothelial cells were shown to be of BBB and are characterized by the tight junctions along with efflux system which are responsible for the restriction of movement of molecules within the cells. Efflux system consists of multidrug resistance proteins such as P-glycoprotein (P-gp). P-gp removes substances out back from the brain to the blood before they reach to the brain. S

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Manickavasagam, Dharani. "Preparation and Characterization of Polymersomes for Nose-to-Brain Delivery of Combination Therapeutics in Neuroinflammation Treatment." Kent State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=kent1555522694193999.

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Hägerström, Helene. "Polymer gels as pharmaceutical dosage forms : rheological performance and physicochemical interactions at the gel-mucus interface for formulations intended for mucosal drug delivery /." Uppsala : Acta Universitatis Upsaliensis, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3538.

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Salade, Laurent. "Development and Characterization of formulations for the nose-to-brain delivery of ghrelin and the management of cachexia." Doctoral thesis, Universite Libre de Bruxelles, 2019. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/293518.

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For many years, the nasal route of administration as part of a therapeutic treatment has been used. This route of administration is easy to implement, especially due to its non-invasiveness the ease of administration that it affords for the patient. In addition, it is suitable for chronic treatment as well as for an emergency situation when the patient is unconscious. For instance, the administration of benzodiazepines, such as midazolam, may be done to stop convulsions in a patient.Traditionally, intranasal administration was mainly borrowed to target a local effect (e.g. treatment of a cold

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Osburg, Berit. "Drug delivery of oligonucleotides at the blood brain barrier a therapeutic strategy for inflammatory diseases of the central nervous system /." [S.l.] : [s.n.], 2003. http://archiv.ub.uni-marburg.de/diss/z2003/0551/.

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Pourbaghi, Masouleh Milad. "Development of lipid nanocapsules for antiangiogenic treatment of glioblastoma and evaluation of their potential for nose-to-brain drug delivery." Thesis, Angers, 2018. http://www.theses.fr/2018ANGE0037.

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Le glioblastome (GB), tumeur primitive du cerveau, la plus agressive, et la plus fréquente chez l’adulte, présente une prolifération vasculaire importante. Des agents thérapeutiques innovants ciblant à la fois l'angiogenèse et les cellules tumorales sont recherchés, ainsi que des systèmes pour augmenter leur délivrance dans la tumeur cérébrale. Un de ces agents est le sorafénib (SFN), un inhibiteur de tyrosine kinase. Sa mauvaise solubilité aqueuse et ses effets secondaires indésirables limitent son utilisation. Le premier objectif de cette thèse était d'encapsuler cet agent dans des nanocapsu

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Bielecki, Peter. "Advanced Mesoporous Silica Nanoparticles for the Treatment of Brain Tumors." Case Western Reserve University School of Graduate Studies / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=case159558503832021.

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Tawfik, Mohamed [Verfasser], and Bernhard A. [Gutachter] Sabel. "Nanoparticles delivery to the central nervous system in-vivo : PVP nanoparticles for brain drug delivery and neuroprotection with siRNA-caspase-3 / Mohamed Tawfik ; Gutachter: Bernhard A. Sabel." Magdeburg : Universitätsbibliothek Otto-von-Guericke-Universität, 2021. http://nbn-resolving.de/urn:nbn:de:gbv:ma9:1-1981185920-387735.

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Gonçalves, Vanessa Santos Silva. "Overcoming Central Nervous System-barriers by the development of hybrid structured systems for nose-to-brain drug delivery using clean technologies." Doctoral thesis, Universidade Nova de Lisboa, Instituto de Tecnologia Química e Biológica António Xavier, 2016. http://hdl.handle.net/10362/56395.

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The effective delivery of therapeutics into the brain is challenging since drugs or drug delivery systems (DDS) candidates are not able to cross the blood-brain barrier (BBB), making the development of new drugs alone not enough to ensure progresses in Central Nervous System (CNS) drug therapy. Due to several problems related with other routes of brain drug administration, the interest has increased towards exploring the possibility of intranasal administration. The nose-to-brain transport and the therapeutic viability of this route have been investigated for rapid and effective transport of d

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Connell, John J. "Selective permeabilisation of the blood-brain barrier at sites of metastasis." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:8c027208-8ea6-4de4-be78-ccead5121509.

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Over one in five cancer patients will develop brain metastases and prognosis remains poor. Effective chemotherapeutics for primary systemic tumours have limited access to brain metastases owing to the blood-brain barrier (BBB). The aim of this study was to develop a strategy for specifically permeabilising the BBB at sites of cerebral metastases. Tumour necrosis factor was injected intravenously into mouse models of haematogenously induced brain metastasis. BBB permeability was assessed through histology and in vivo MRI and SPECT. Tumour burden and neuroinflammation were assessed after injecti

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Certo, Francesco. "Technological innovations in multimodal management of glioblastoma: from nano-drugs to imaging guided surgery and supra-maximal resection." Doctoral thesis, Università di Catania, 2018. http://hdl.handle.net/10761/4189.

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Primary brain tumors are a major cause of morbidity and mortality in the United States. Approximately one-third of tumors are malignant and the remaining are benign or borderline malignant. High-grade glioma, in particular glioblastoma, management is a great challenge for both neurosurgeons and patients. More than 45% of CNS primary malignant tumours are glioblastoma and their 5 year-survival is only 5% on average. Although biomolecular differences between glioblastoma IDH-WT and IDH-mutant might account for different outcomes, treatment strategies, including surgical EOR, chemiotherapy and ra

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Zhang, Yajie. "Multimodal Imaging PLGA Nanocapsules as Protein Carrier for Potential Neurorepair in Ischemic Brain." Doctoral thesis, Universitat Autònoma de Barcelona, 2020. http://hdl.handle.net/10803/671000.

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Els avenços en sistemes nanoparticulats capaços de proporcionar les funcionalitats necessàries a les noves nanomedicines i oferir la possibilitat de combinar la detecció no invasiva de malalties amb tractaments individualitzats estan convertint en realitat la medicina personalitzada. A més, els progressos en teranòstica estan configurant el desenvolupament de l’ administració de fàrmacs guiats per imatge que milloren l’eficiència en el tractament, visualitzant les seves biodistribucions, efectes sobre les dianes moleculars i cel·lulars específiques i els efectes terapèutics corresponents. Aque

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Kohli, Neha. "Amelioration of Amyloid Burden in Advanced Human and Mouse Alzheimer's Disease Brains by Oral Delivery of Myelin Basic Protein Bioencapsulated in Plant Cells." Master's thesis, University of Central Florida, 2012. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/5380.

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One of the pathological hallmarks of Alzheimer's disease (AD) is the amyloid plaque deposition in aging brains by aggregation of amyloid-? (A?) peptides. In this study, the effect of chloroplast derived myelin basic protein (MBP) fused with cholera toxin subunit B (CTB) was investigated in advanced diseased stage of human and mouse AD brains. The CTB-fusion protein in chloroplasts facilitates transmucosal delivery in the gut by the natural binding ability of CTB pentameric form with GM1 receptors on the intestinal epithelium. Further, bioencapsulation of the MBP within plant cells confers prot

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Vaccari, Pietro <1991&gt. "Synthesis and Characterization of Polymeric Nanoparticles for Delivery Through the Blood Brain Barrier of Drugs Against the Human African Trypanosomiasis." Master's Degree Thesis, Università Ca' Foscari Venezia, 2016. http://hdl.handle.net/10579/8017.

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In questo lavoro di tesi si sono sintetizzate nanoparticelle di poly(lactic-co-glycolic acid) al fine di incapsulare dei farmaci utili alla cura della tripanosomiasi africana umana. Le due molecole scelte per essere incapsulate sono la Suramina e la Pentamidina, ad oggi utilizzate per curare la sindrome nella prima fase di infezione, quando il parassita si trova ancora nel flusso sanguigno. Nel decorso della malattia il parassita invade anche il sistema nervoso centrale rendendo vano il trattamento con i farmaci sovracitati in quanto, non essendo presente un loro target molecolare sulla Barrie

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TRUZZI, ELEONORA. "PROGETTAZIONE E SVILUPPO DI SISTEMI DI VEICOLAZIONE NANOPARTICELLARI A BASE DI LIPIDI E OLIGOSACCARIDI PER LA SOMMINISTRAZIONE DI COMPOSTI ATTIVI." Doctoral thesis, Università degli studi di Modena e Reggio Emilia, 2020. http://hdl.handle.net/11380/1201019.

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I sistemi di veicolazione del farmaco sono largamente studiati come tra i più efficienti metodi per migliorare l’efficacia dei farmaci. Negli ultimi vent’anni un’enorme attenzione è stata focalizzata sui sistemi nanometrici di veicolazione che sono in grado di interagire selettivamente con organismi patogeni, cellule o tessuti. Tra i gli eccipienti utilizzabili nella preparazione di questi sistemi, lipidi e oligosaccaridi mostrano una elevata biocompatibilità, biodegradabilità e idoneità per la somministrazione di farmaci attraverso varie vie. Lo scopo della tesi è stato lo sviluppo di sistemi

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Munson, Jennifer Megan. "Novel nanocarriers for invasive glioma." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/41226.

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The invasive nature of glioblastoma (GBM) represents a significant challenge to the standard of care and contributes to poor clinical outcomes. Invasion of tumors into healthy brain restricts chemotherapeutic access and complicates surgical resection. The central hypothesis of the thesis is that an effective anti-invasive agent can enhance the standard chemotherapeutic response in invasive brain tumors. Through a screen of novel compounds, a new anti-invasive small molecule, Imipramine Blue (IB), was identified. This triphenylmethane compound inhibits invasion of highly invasive glioma in vit

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