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Thematische Bibliographien / Drug utilization review methods / Zeitschriftenartikel

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Zeitschriftenartikel zum Thema „Drug utilization review methods“

Autor: Grafiati

Veröffentlicht am 4. Juni 2021

Zuletzt aktualisiert am 7. Februar 2022

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Meena, Dinesh Kumar, and M. Jayanthi. "Drug utilization research: a review." International Journal of Basic & Clinical Pharmacology 8, no. 2 (2019): 354. http://dx.doi.org/10.18203/2319-2003.ijbcp20190161.

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Data from drug utilization research is an invaluable resource for all stake holders involved in drug and health policies. Drug utilization is “marketing, distribution, prescription and use of drugs in a society, with special emphasis on the resulting medical, social and economic consequences”. Research on drug utilization includes factors related to prescribing, dispensing, administering and intake of medication and its associated events. The ultimate purpose of drug utilization research is to estimate the optimal quality of drug therapy by identifying, documenting, analysing problems in drug

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Anureet Arora, Manju Nagpal, and Geeta Aggarwal. "Microneedle Mediated Vaccine Delivery: A Comprehensive Review." Journal of Pharmaceutical Technology, Research and Management 5, no. 2 (2017): 163–84. http://dx.doi.org/10.15415/jptrm.2017.52011.

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Microneedles can be representative for paradigm shift of drug delivery from patient non-compliant parenteral injections to patient compliant drug delivery system, which can be utilized for administration of vaccines particularly along with macromolecular/micromolecular drugs. The concept of microneedles came into existence many decades ago but the use of microneedles to achieve efficient delivery of drugs into the skin became subject of research from mid of 1990’s. Various types of microneedles were utilized to enhance delivery of drugs and vaccines including solid microneedles for pre-treatme

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Durán, Carlos E., Thierry Christiaens, Ángela Acosta, and Robert Vander Stichele. "Systematic review of cross-national drug utilization studies in Latin America: methods and comparability." Pharmacoepidemiology and Drug Safety 25, no. 1 (2015): 16–25. http://dx.doi.org/10.1002/pds.3896.

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Su ol, R., C. Abello, and I. C. Cels. "STUDIES IN UTILIZATION OF DRUGS: A REVIEW OF DIFFERENT METHODS." International Journal for Quality in Health Care 3, no. 1 (1991): 63–72. http://dx.doi.org/10.1093/intqhc/3.1.63.

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Chabot, Isabelle, Johanne Morin, Kateri Bourbeau, and Jocelyne Moisan. "A Comparison of Retrospective and Concurrent Drug Utilization Review of Omeprazole." Journal of Pharmacy Technology 14, no. 5 (1998): 202–8. http://dx.doi.org/10.1177/875512259801400507.

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Objective: To compare the appropriateness of omeprazole prescriptions in a concurrent drug utilization review (DUR) with the assessed appropriateness of a retrospective DUR. Methods: A retrospective DUR of omeprazole was conducted on prescriptions written from August 23, 1993, to October 8, 1993, in a 340-bed university hospital. This DUR served as a baseline for a concurrent DUR that began on January 27, 1995, and ended on March 16, 1995. The concurrent DUR integrated three steps aimed at improving the quality of omeprazole use: Approval of the criteria by the pharmacology and therapeutics co

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Piacentini, Emma, Marijana Dragosavac, and Lidietta Giorno. "Pharmaceutical Particles Design by Membrane Emulsification: Preparation Methods and Applications in Drug Delivery." Current Pharmaceutical Design 23, no. 2 (2017): 302–18. http://dx.doi.org/10.2174/1381612823666161117160940.

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Nowadays, the rational design of particles is an important issue in the development of pharmaceutical medicaments. Advances in manufacturing methods are required to design new pharmaceutical particles with target properties in terms of particle size, particle size distribution, structure and functional activity. Membrane emulsification is emerging as a promising tool for the production of emulsions and solidified particles with tailored properties in many fields. In this review, the current use of membrane emulsification in the production of pharmaceutical particles is highlighted. Membrane em

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Sequi, Marco, Rita Campi, Antonio Clavenna, and Maurizio Bonati. "Methods in pharmacoepidemiology: a review of statistical analyses and data reporting in pediatric drug utilization studies." European Journal of Clinical Pharmacology 69, no. 3 (2012): 599–604. http://dx.doi.org/10.1007/s00228-012-1354-y.

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Morrison, Alena, Neil J. MacKinnon, Nicole R. Hartnell, and Karen J. McCaffrey. "Impact of Drug Plan Management Policies in Canada: A Systematic Review." Canadian Pharmacists Journal / Revue des Pharmaciens du Canada 141, no. 6 (2008): 332–38. http://dx.doi.org/10.3821/1913-701x-141.6.332.

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Background/objective: In Canada, pharmaceutical expenditures require an increasing proportion of total health care dollars. Drug plan managers use various policies to manage medication use and control costs, but these policies can have unintended consequences. The objective of this systematic review is to evaluate the impact of drug policies on economic, clinical and humanistic (quality of life or satisfaction) outcomes. Methods: Articles in which the primary objective was to evaluate the impact of a drug policy tool or technique in Canada and that measured one or more economic, clinical or hu

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Babasahib, S. K., S. Maria, and S. Chillakunnel Hussain Rawther. "Drug Utilization and Cost Analysis Review of Anticancer Drugs Used in a Tertiary Care Teaching Hospital in South India." Journal of Global Oncology 4, Supplement 2 (2018): 73s. http://dx.doi.org/10.1200/jgo.18.43100.

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Background: Cancer is ranked high among noncommunicable diseases and millions of people in India receive treatment of cancer every year. Aim: The current study aims to evaluate the trends and pattern of prescribing of anticancer drugs. The objectives of the study were to assess the rational use of anticancer drugs, to identify various types of cancer and to analyze the cost distribution of anticancer drugs. Methods: An observational, prospective study was conducted in 200 prescriptions in oncology department. Data were collected from case reports, prescriptions and medication charts in special

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Hertler, Andrew, Sang Chau, Rani Khetarpal, et al. "Utilization of Clinical Pathways Can Reduce Drug Spend Within the Oncology Care Model." JCO Oncology Practice 16, no. 5 (2020): e456-e463. http://dx.doi.org/10.1200/jop.19.00753.

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PURPOSE: Reducing drug spend is one of the greatest challenges for practices participating in the Oncology Care Model (OCM). Evidence-based clinical pathways have the potential to decrease drug spend while maintaining clinical outcomes consistent with published evidence. The goal of this study was to determine whether voluntary use of clinical pathways by a practice can maximize OCM episodic cost savings. METHODS AND MATERIALS: A community oncology practice used evidence-based clinical pathways for OCM-attributed patients. All treatment plans were submitted to the pathway vendor in real time f

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Wuri, Rahmitiana, Aziis Mardanarian Rosdianto, and Hanna Goenawan. "UTILIZATION OF RATS AS BLUNT TRAUMA ANIMALS MODEL: A LITERATURE REVIEW." Indonesia Medicus Veterinus 10, no. 2 (2021): 338–54. http://dx.doi.org/10.19087/imv.2021.10.2.338.

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The occurrence of contusion in humans and animals becomes an interesting study material, many researchers search and do a treatment formulation for contusion. The various effects of applying a new substance/drug to humans can be determined by studying cumulative effect of doses at the preclinical stage. The information was obtained from conducting laboratory experiments in vivo using experimental animals as a model designed in preclinical tests, such as using rats (Rattus norvegicus). So far, the development of using rat as an animal model of contusion is still very potential for further study

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Nguyen, Thang Phan, Quang Vinh Nguyen, Van-Huy Nguyen, et al. "Silk Fibroin-Based Biomaterials for Biomedical Applications: A Review." Polymers 11, no. 12 (2019): 1933. http://dx.doi.org/10.3390/polym11121933.

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Since it was first discovered, thousands of years ago, silkworm silk has been known to be an abundant biopolymer with a vast range of attractive properties. The utilization of silk fibroin (SF), the main protein of silkworm silk, has not been limited to the textile industry but has been further extended to various high-tech application areas, including biomaterials for drug delivery systems and tissue engineering. The outstanding mechanical properties of SF, including its facile processability, superior biocompatibility, controllable biodegradation, and versatile functionalization have allowed

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Schwartz, David N., R. Scott Evans, Bernard C. Camins, et al. "Deriving Measures of Intensive Care Unit Antimicrobial Use from Computerized Pharmacy Data: Methods, Validation, and Overcoming Barriers." Infection Control & Hospital Epidemiology 32, no. 5 (2011): 472–80. http://dx.doi.org/10.1086/659760.

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Objective.To outline methods for deriving and validating intensive care unit (ICU) antimicrobial utilization (AU) measures from computerized data and to describe programming problems that emerged.Design.Retrospective evaluation of computerized pharmacy and administrative data.Setting.ICUs from 4 academic medical centers over 36 months.Interventions.Investigators separately developed and validated programming code to report AU measures in selected ICUs. Use of antibacterial and antifungal drugs for systemic administration was categorized and expressed as antimicrobial-days (each day that each a

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Ma, Ruijuan, Baobei Wang, Elvis T. Chua, et al. "Comprehensive Utilization of Marine Microalgae for Enhanced Co-Production of Multiple Compounds." Marine Drugs 18, no. 9 (2020): 467. http://dx.doi.org/10.3390/md18090467.

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Marine microalgae are regarded as potential feedstock because of their multiple valuable compounds, including lipids, pigments, carbohydrates, and proteins. Some of these compounds exhibit attractive bioactivities, such as carotenoids, ω-3 polyunsaturated fatty acids, polysaccharides, and peptides. However, the production cost of bioactive compounds is quite high, due to the low contents in marine microalgae. Comprehensive utilization of marine microalgae for multiple compounds production instead of the sole product can be an efficient way to increase the economic feasibility of bioactive comp

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Sun, Ying, Xiaoli Ma, and Hao Hu. "Marine Polysaccharides as a Versatile Biomass for the Construction of Nano Drug Delivery Systems." Marine Drugs 19, no. 6 (2021): 345. http://dx.doi.org/10.3390/md19060345.

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Marine biomass is a treasure trove of materials. Marine polysaccharides have the characteristics of biocompatibility, biodegradability, non-toxicity, low cost, and abundance. An enormous variety of polysaccharides can be extracted from marine organisms such as algae, crustaceans, and microorganisms. The most studied marine polysaccharides include chitin, chitosan, alginates, hyaluronic acid, fucoidan, carrageenan, agarose, and Ulva. Marine polysaccharides have a wide range of applications in the field of biomedical materials, such as drug delivery, tissue engineering, wound dressings, and sens

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Ferrentino, Giovanna, Ksenia Morozova, Christine Horn, and Matteo Scampicchio. "Extraction of Essential Oils from Medicinal Plants and their Utilization as Food Antioxidants." Current Pharmaceutical Design 26, no. 5 (2020): 519–41. http://dx.doi.org/10.2174/1381612826666200121092018.

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Background: The use of essential oils is receiving increasing attention worldwide, as these oils are good sources of several bioactive compounds. Nowadays essential oils are preferred over synthetic preservatives thanks to their antioxidant and antimicrobial properties. Several studies highlight the beneficial effect of essential oils extracted from medicinal plants to cure human diseases such as hypertension, diabetes, or obesity. However, to preserve their bioactivity, the use of appropriate extraction technologies is required. Method: The present review aims to describe the studies publishe

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Reshetko, Olga V., Konstantin A. Lutsevich, and Irina I. Sanina. "Pharmacological Safety in Pregnancy: A Systematic Review On the Use of Potentially Teratogenic Drugs." Pediatric pharmacology 14, no. 2 (2017): 127–41. http://dx.doi.org/10.15690/pf.v14i2.1727.

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Objective: To assess the prevalence of potentially teratogenic drug utilization by pregnant women: overall and in the periconceptional period. Methods: The electronic database PubMed/Medline was searched for the following keywords: «pharmacoepidemiology», «pregnancy», «drug use», «safety», «pregnancy risk category», «fetal risk», «teratogen». The systematic analysis included 28 studies published in English from January 2006 to 23 December 2015. Results. The review shows that the study designs and the choices for data analysis and presentation of results differ largely across published studies.

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Wong, Kara R., Leigh Anne Nelson, Ellie S. R. Elliott, Yifei Liu, Roger W. Sommi, and Elizabeth A. Winans. "Utilization of antipsychotic therapeutic drug monitoring at a state psychiatric hospital." Mental Health Clinician 6, no. 1 (2016): 1–7. http://dx.doi.org/10.9740/mhc.2016.01.001.

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Abstract Introduction This study assesses the utilization of antipsychotic therapeutic drug monitoring (TDM) and describes characteristics of appropriate and inappropriate TDM at a state psychiatric hospital. Methods A retrospective, descriptive review was conducted for antipsychotic TDM completed between December 1, 2009, and June 30, 2011, at a 65-bed adult inpatient extended-care and forensic state psychiatric hospital. Results One hundred thirty-three (n = 133) antipsychotic serum levels were collected from 44 patients during the study period. Sixty-nine percent (69%) of the TDM were deeme

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Tarride, Jean-Eric, Morgan E. Lim, James M. Bowen, et al. "In search of the evidentiary foundation of published Canadian economic evaluations (2001–06)." International Journal of Technology Assessment in Health Care 25, no. 02 (2009): 214–21. http://dx.doi.org/10.1017/s0266462309090278.

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Objectives:The aim of this study was to present a review of economic evaluations conducted from a Canadian perspective and to characterize sources of evidence and statistical methods to analyze effectiveness measures, resource utilization, and uncertainty.Methods:A search strategy was developed to identify Canadian economic evaluations published between January 2001 and June 2006. A standardized abstraction form was used to extract key data (e.g., study design, data sources, statistical methods).Results:A total of 153 unique studies were included for review, of which 75 were evaluations of dru

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Yazaki, Yoshikazu. "Utilization of Flavonoid Compounds from Bark and Wood: A Review." Natural Product Communications 10, no. 3 (2015): 1934578X1501000. http://dx.doi.org/10.1177/1934578x1501000333.

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Flavonoid compounds, which are extracted from bark and wood and used commercially, are flavan 3-ols as monomers and their polymers, which are called “condensed tannins”. Reactions of the condensed tannins with formaldehyde are the basis for wood adhesives. In the late 1940s, tannin research for wood adhesives was begun and the world-first commercial use of wattle tannin from black wattle ( Acacia mearnsii) bark as wood adhesives occurred in Australia in the 1960s. In addition, wattle tannin-based adhesives were further developed in South Africa and the uses of these adhesives have been continu

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Hohl, C. M., M. E. Wickham, K. McGrail, and B. G. Sobolev. "P062: Impact of pharmacist-led medication review in the emergency department on downstream health services utilization." CJEM 18, S1 (2016): S99. http://dx.doi.org/10.1017/cem.2016.238.

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Introduction: Adverse drug events are a leading cause of Emergency Department (ED) visits and unplanned admissions. Up to 50% are misdiagnosed in the ED and on hospital wards leading to treatment delays. Our main objective was to evaluate the effect of pharmacist-led medication review in high-risk ED patients on the number of days in-hospital. Our hypothesis was that early pharmacist-led medication review may reduce the number of days spent in-hospital. Methods: We evaluated a quality improvement program that was implemented in three British Columbian EDs. During a 12-month period, nurses iden

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Mahmood, Muhammad Arif. "3D Printing in Drug Delivery and Biomedical Applications: A State-of-the-Art Review." Compounds 1, no. 3 (2021): 94–115. http://dx.doi.org/10.3390/compounds1030009.

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Personalized medicines are gaining popularity day by day as they empower patient genomics and assist in improved drug design with minimum side effects. Various dosages can be combined into one dose that fits the patient’s requirements. For this purpose, 3D printing is a new technology to produce medicine based on patient needs. It utilizes controlled devices to prepare active pharmaceutical ingredients (API) in a layer-wise fashion to develop an appropriate tailored drug transport structure. It contains numerous methods, including inkjet printing and fused deposition modeling. For this purpose

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Qassemi, Soraya, Arnaud Pagès, Laure Rouch, et al. "Potentially Inappropriate Drug Prescribing in French Nursing Home Residents: An Observational Study." Pharmacy 8, no. 3 (2020): 133. http://dx.doi.org/10.3390/pharmacy8030133.

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Purpose: To identify the prevalence of potentially inappropriate drug prescription in a sample of nursing home residents in France, combining explicit criteria and implicit approach and to involve pharmacists in the multi-professional process of therapeutic optimization. Methods: A cross-sectional, observational, multicenter study was conducted during a five-month period in a sample of French nursing homes. Information on drug prescription, diseases, and socio-demographic characteristics of nursing home residents was collected. For each prescription, identification of potentially inappropriate

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Mishra, Vaibhav, and Tejpal Singh Chundawat. "Pd Catalyzed N1/N4 Arylation of Piperazine for Synthesis of Drugs, Biological and Pharmaceutical Targets: An Overview of Buchwald Hartwig Amination Reaction of Piperazine in Drug Synthesis." Current Organic Synthesis 15, no. 2 (2018): 208–20. http://dx.doi.org/10.2174/1570179415666171206151603.

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Background: Substituted piperazine heterocycles are among the most significant structural components of pharmaceuticals. N1/N4 substituted piperazine containing drugs and biological targets are ranked 3rd in the top most frequent nitrogen heterocycles in U.S. FDA approved drugs. The high demand of N1/N4 substituted piperazine containing biologically active compounds and U.S. FDA approved drugs, has prompted the development of Pd catalyzed C-N bond formation reactions for their synthesis. Buchwald-Hartwig reaction is the key tool for the synthesis of these compounds. Objective: This review prov

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Rabiei, Morteza, Soheila Kashanian, Seyedeh S. Samavati, Shahriar Jamasb, and Steven J. P. McInnes. "Active Targeting Towards and Inside the Brain based on Nanoparticles: A Review." Current Pharmaceutical Biotechnology 21, no. 5 (2020): 374–83. http://dx.doi.org/10.2174/1389201020666191203094057.

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Background: Treatment of neurological diseases using systemic and non-surgical techniques presents a significant challenge in medicine. This challenge is chiefly associated with the condensation and coherence of the brain tissue. Methods: The coherence structure of the brain is due to the presence of the blood-brain barrier (BBB), which consists of a continuous layer of capillary endothelial cells. The BBB prevents most drugs from entering the brain tissue and is highly selective, permitting only metabolic substances and nutrients to pass through. Results: Although this challenge has caused di

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Xing, Maochen, Qi Cao, Yu Wang, et al. "Advances in Research on the Bioactivity of Alginate Oligosaccharides." Marine Drugs 18, no. 3 (2020): 144. http://dx.doi.org/10.3390/md18030144.

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Alginate is a natural polysaccharide present in various marine brown seaweeds. Alginate oligosaccharide (AOS) is a degradation product of alginate, which has received increasing attention due to its low molecular weight and promising biological activity. The wide-ranging biological activity of AOS is closely related to the diversity of their structures. AOS with a specific structure and distinct applications can be obtained by different methods of alginate degradation. This review focuses on recent advances in the biological activity of alginate and its derivatives, including their anti-tumor,

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Ghazizadeh, Shabnam, Kyasha Moore, Kianusch Kiai, and Abie H. Mendelsohn. "Drug-Induced Sleep Endoscopy Performed in the Endoscopy Suite: A Resource Utilization Analysis." Otolaryngology–Head and Neck Surgery 162, no. 3 (2020): 386–91. http://dx.doi.org/10.1177/0194599820901516.

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Objectives To analyze the resource utilization of performing drug-induced sleep endoscopy (DISE) procedures in an endoscopy suite (ES) setting as compared with the operating room (OR). Study Design A retrospective review of DISE procedures performed by a single attending surgeon from 2016 to 2018. Setting Tertiary hospital. Subjects and Methods All patients undergoing sleep endoscopy without concurrent surgical procedures were included. No exclusion criteria were incorporated. Analysis assessed for differences in procedure-related expenditures, patient characteristics, anesthesia and surgeon t

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Simbeye, Joel, Elham Navab, and Fatemeh Bahramnezhad. "Pain Management Interventions for Drug-addicted Patients Admitted in Intensive Care Units: An Integrative Review." Open Nursing Journal 14, no. 1 (2020): 240–47. http://dx.doi.org/10.2174/1874434602014010240.

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Background: Pain management interventions among critically ill drug-addicted patients admitted to ICUs are still the major challenge faced by healthcare practitioners. Objective: Therefore, this study aimed to identify and appraise the pain management approaches of patients with drug addiction (substance use disorder) admitted in ICUs. Methods: An integrative review of the literature was performed; narrative data synthesis was used for data extraction. The search was performed using scientific databases, including Google Scholar, PubMed, Scopus, Web of Science, Ovid Medline and EMBASE from Jan

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Grothen, Andrew E., Bethany Tennant, Catherine Wang, et al. "Application of Artificial Intelligence Methods to Pharmacy Data for Cancer Surveillance and Epidemiology Research: A Systematic Review." JCO Clinical Cancer Informatics, no. 4 (November 2020): 1051–58. http://dx.doi.org/10.1200/cci.20.00101.

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PURPOSE The implementation and utilization of electronic health records is generating a large volume and variety of data, which are difficult to process using traditional techniques. However, these data could help answer important questions in cancer surveillance and epidemiology research. Artificial intelligence (AI) data processing methods are capable of evaluating large volumes of data, yet current literature on their use in this context of pharmacy informatics is not well characterized. METHODS A systematic literature review was conducted to evaluate relevant publications within four domai

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Sabatino, David, Michael Tillman, Jayne Pawasauskas, and Todd Brothers. "Nonsteroidal anti-inflammatory drug induced acute kidney injury; A review and case study." Journal of Renal Injury Prevention 9, no. 4 (2020): e30-e30. http://dx.doi.org/10.34172/jrip.2020.30.

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Introduction: The use of nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly therapeutic classes and are responsible for ten percent of medications dispensed annually. Twelve percent of individuals currently report taking a NSAID daily. Renal injury caused by these agents can present in various forms, resulting from either acute or chronic use. Historically approximately five percent of patients initiated on NSAIDs experience a kidney-related adverse event. Drug-induced renal injury accounts for twenty percent of episodes of acute kidney injury (AKI). Patients requiring

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Strevel, Elizabeth L., Douglas J. Ing, and Lillian L. Siu. "Molecularly Targeted Oncology Therapeutics and Prolongation of the QT Interval." Journal of Clinical Oncology 25, no. 22 (2007): 3362–71. http://dx.doi.org/10.1200/jco.2006.09.6925.

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Investigation and utilization of molecularly targeted agents has induced a number of drug adverse effects that are not typically associated with conventional chemotherapy. QT interval prolongation, a cardiac toxicity that increases the risk of fatal arrhythmia, is associated with several novel oncology therapies. Classes of molecularly targeted agents with described QT effects include histone deacetylase inhibitors, multitargeted tyrosine kinase inhibitors, vascular disruption agents, farnesyl protein transferase inhibitors, Src/Abl kinase inhibitors, and protein kinase C inhibitors. Concurren

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Poirier, Marie-Belle, Maria Benkhalti, Jérémy Joncas, et al. "PP506 Health Technology Reassessment (HTR) Of A Non-Drug Technology: Methods Used By A Regional HTA Unit." International Journal of Technology Assessment in Health Care 36, S1 (2020): 40. http://dx.doi.org/10.1017/s0266462320001889.

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IntroductionAn environmental scan conducted by the Canadian Agency for Drugs and Technologies (CADTH-March-2019) revealed that several health technology assessment (HTA) organisations are currently developing standard health technology reassessment (HTR) processes. Here we present methods used to conduct an HTR of a prioritization programme for non-immediate life-threatening urgent surgeries implemented in 2017 at a tertiary referral hospital in (Quebec-Canada). This HTR initiative was conducted by a regional HTA unit to optimize the programme efficiency and resources utilization as well as to

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Fan, Mingxue, Sicong Geng, Yang Liu, et al. "Nanocrystal Technology as a Strategy to Improve Drug Bioavailability and Antitumor Efficacy for the Cancer Treatment." Current Pharmaceutical Design 24, no. 21 (2018): 2416–24. http://dx.doi.org/10.2174/1381612824666180515154109.

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Background and Objective: Nanocrystal technology is an effective approach which can increase the dissolution rate of poorly water-soluble drugs by raising their saturation solubility, thus improving the drug bioavailability. With the development of nanocrystals, its preparation approaches have gradually matured, which can be generally divided into Bottom-up, Top-down and Combinative technologies. Methods: A systematic literature review in the field of nanocrystal technology for the cancer treatment was scanned and collected data was detailedly analyzed and summarized. Results: Over the past de

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AlSalman, Ahmad, Craig P. Worby, emma Considine, Ritika Zijoo, and Colleen Kershaw. "599. Dalbavancin Utilization in Rural Healthcare Setting: A Single Center Three Years’ Experience." Open Forum Infectious Diseases 7, Supplement_1 (2020): S362. http://dx.doi.org/10.1093/ofid/ofaa439.793.

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Abstract Background Dalbavancin is a second generation lipoglycopeptide, approved by the Food and Drug Administration (FDA) for treatment of acute bacterial skin and skin structure infections (ABSSSI). The weekly dosing of Dalbavancin has encouraged its off-label use to treat other severe infections, especially in patients deemed to be poor candidates for intravenous antimicrobial therapy through a long-term intravenous catheter. Methods Single center retrospective chart review of 33 patients who were planned to receive Dalbavancin between March 2015 and March 2019 at a rural medical center in

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Gregory, Philip J., Mohamed A. Jalloh, Andrew M. Abe, James Hu, and Darren J. Hein. "Characterization of Complementary and Alternative Medicine-Related Consultations in an Academic Drug Information Service." Journal of Pharmacy Practice 29, no. 6 (2016): 539–42. http://dx.doi.org/10.1177/0897190015579450.

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Purpose: To characterize requests received through an academic drug information consultation service related to complementary and alternative medicines. Methods: A retrospective review and descriptive analysis of drug information consultations was conducted. Results: A total of 195 consultations related to complementary and alternative medicine were evaluated. All consultation requests involved questions about dietary supplements. The most common request types were related to safety and tolerability (39%), effectiveness (38%), and therapeutic use (34%). Sixty-eight percent of the requests were

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Gilbert, Brian, James R. Morales, Randi J. Searcy, Donald W. Johnson, and Jason A. Ferreira. "Evaluation of Neuroleptic Utilization in the Intensive Care Unit During Transitions of Care." Journal of Intensive Care Medicine 32, no. 2 (2016): 158–62. http://dx.doi.org/10.1177/0885066615622424.

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Purpose: The purpose of this study was to identify risk factors associated with inappropriate continuation of neuroleptics postdischarge from the intensive care unit (ICU) and hospital. Materials and Methods: A retrospective chart review was performed including all patients greater than 18 years of age who received neuroleptic medications in an ICU. Results: One hundred sixty-one patients were included during the 12- month study period. There were 85 (53%) patients discharged from the ICU with inappropriate continuation of a neuroleptic medication. There were 54 (34%) patients discharged from

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Luther, Kiranjit, Guang Mei Fung, and Farah Khorassani. "Cost Comparison of Atypical Antipsychotics: Paliperidone ER and Risperidone." Hospital Pharmacy 54, no. 6 (2018): 389–92. http://dx.doi.org/10.1177/0018578718809269.

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Purpose: Paliperidone and risperidone are atypical antipsychotics that are structurally and therapeutically similar. Risperidone is metabolized by the liver via cytochrome (CYP) 2D6 to an active metabolite, 9-hydroxyrisperidone. The atypical antipsychotic paliperidone is 9-hydroxyrisperidone formulated separately as an extended-release (ER) tablet and is considerably more expensive than risperidone. The purpose of this retrospective drug utilization review is to evaluate the prescribing patterns of paliperidone ER and evaluate potential cost savings by converting paliperidone ER orders to risp

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Sharma, Bharat, Neeru Vasudeva, and Sunil Sharma. "Phytopharmacological Review on Crinum asiaticum: A Potential Medicinal Herb." Natural Products Journal 10, no. 4 (2020): 342–54. http://dx.doi.org/10.2174/2210315509666190731142333.

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Background: Herbs have been used since ancient times for the treatment of various ailments. One such herb is Sudershan which has widely been used (Crinum asiaticum, family Amaryllidaceae), in traditional and Ayurvedic systems of medicines in India, Hongkong, Sri Lanka, China, Thailand and other countries due to its efficacy in curing and preventing of various diseases. Hence, the compilation of the botanical, ethnomedical uses and phytoconstituents data will be of great benefit to mankind. Method: The literature review of the plant was collected from various databases viz. Web of Science, PubM

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Noel, Christopher. "A review of a recently published guidelines' “strong recommendation” for therapeutic drug monitoring of olanzapine, haloperidol, perphenazine, and fluphenazine." Mental Health Clinician 9, no. 4 (2019): 287–93. http://dx.doi.org/10.9740/mhc.2019.07.287.

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Abstract Introduction In addition to clozapine, there is a growing body of evidence that supports therapeutic drug monitoring (TDM) for additional antipsychotics commonly used in the United States. Methods The Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie (AGNP) published TDM guidelines for several psychiatric medications. Sources were identified that the authors used to establish therapeutic reference ranges for haloperidol, fluphenazine, perphenazine, and olanzapine—4 antipsychotics commonly used in the United States with a “strong recommendation” for TDM. The sour

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Kanazawa, Junichiro, and Masanobu Uchiyama. "Recent Advances in the Synthetic Chemistry of Bicyclo[1.1.1]pentane." Synlett 30, no. 01 (2018): 1–11. http://dx.doi.org/10.1055/s-0037-1610314.

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Utilization of three-dimensional cyclic scaffolds is important in modern drug discovery, both to provide greater opportunities for optimizing drug candidates and to expand the available chemical space of drugs. Among these scaffolds, bicyclo[1.1.1]pentane (BCP) is a high-value bioisostere for 1,4-disubstituted phenyl rings, internal alkynes, and the tert-butyl group, generally offering high passive permeability, high water solubility, and improved metabolic stability. However, the lack of methods for functionalizing BCP remains a significant challenge, and in particular, a versatile strategy f

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Sehgal, Nalini. "Prescription Opioid Abuse in Chronic Pain: A Review of Opioid Abuse Predictors and Strategies to Curb Opioid Abuse." July 2012 3S;15, no. 3S;7 (2012): S67—ES92. http://dx.doi.org/10.36076/ppj.2012/15/es67.

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Both chronic pain and prescription opioid abuse are prevalent and continue to exact a heavy toll on patients, physicians, and society. Individuals with chronic pain and co-occurring substance use disorders and/or mental health disorders, are at a higher risk for misuse of prescribed opioids. Opioid abuse and misuse occurs for a variety of reasons, including self medication, use for reward, compulsive use because of addiction, and diversion for profit. Treatment approaches that balance treating chronic pain while minimizing risks for opioid abuse, misuse, and diversion are much needed. The use

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Napoli, Emma, Jasmin K. Badwal, Emily R. Kirkpatrick, Ruth Serrano Pinilla, Chen-Pin Wang, and Heta Javeri. "314. A Retrospective Review of Dalbavancin Utilization at an Academic Medical Center." Open Forum Infectious Diseases 7, Supplement_1 (2020): S229. http://dx.doi.org/10.1093/ofid/ofaa439.510.

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Abstract Background Dalbavancin is a novel long-acting lipoglycopeptide with increasing utilization for management of bone and joint infections as a two-dose regimen. The purpose of this study is to describe the patient characteristics, evaluate clinical outcomes, and calculate inpatient hospital days saved with use of dalbavancin as outpatient parenteral antimicrobial therapy (OPAT). Methods A retrospective review of patients treated with dalbavancin at University Hospital was conducted from Aug 2019- March 2020. Patients ≥ 17 yrs of age with plan to receive at least 1 dose of dalbavancin wer

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Bielick, Catherine G., Ryan D. Knodle, Shana Burrowes, and Tamar F. Barlam. "1562. Reduction in Healthcare Utilization and Overdose after Skin and Soft Tissue Infections for Injection Drug Users through Addiction Medicine Consultation." Open Forum Infectious Diseases 7, Supplement_1 (2020): S780. http://dx.doi.org/10.1093/ofid/ofaa439.1742.

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Abstract Background Healthcare encounters for skin and soft tissue infections (SSTIs) due to injection drug use (IDU) may provide opportunities for interventions to improve outcomes. We explored factors that may impact reduction of healthcare utilization and modify other complications of substance use disorder after an IDU-related SSTI. Methods We conducted a retrospective cohort chart review for 305 patients with IDU-related SSTIs between 10/1/2015 and 6/1/2019 to examine demographic, clinical and healthcare utilization data one year before and after the SSTI encounter. Patients were categori

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Samad, Mohammed Abdul, Kavya Pandiri, and Anjani Prasad Bojanapally. "Antisense Oligonucleotides: Pharmacology and Delivery Strategies." INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH 5, no. 01 (2020): 7–11. http://dx.doi.org/10.21477/ijapsr.5.1.2.

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Antisense oligonucleotide therapy is a dominant drug discovery approach that can explicitly modify protein synthesis through numerous mechanisms. The limitations of antisense oligonucleotide (ASO) therapy in delivery strategies have been overcome in recent years with different ligands carriers, as well as, through nanocarriers. ASO therapy was successfully applied towards targeting a wide range of therapeutic areas. There is an expanding enthusiasm in extending the utilization of antisense compounds to numerous different diseases due to their safe and potential therapeutic outcomes. Thus, the

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Sheth, Heena S., Margaret M. Verrico, Susan J. Skledar, and Adele L. Towers. "Promethazine Adverse Events after Implementation of a Medication Shortage Interchange." Annals of Pharmacotherapy 39, no. 2 (2005): 255–61. http://dx.doi.org/10.1345/aph.1e361.

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BACKGROUND: Prochlorperazine and droperidol were commonly used antiemetics at the University of Pittsburgh Medical Center– Presbyterian Hospital until a shortage of prochlorperazine occurred and a black box warning was added to droperidol prescribing information. Subsequently, promethazine was selected as the approved intravenous antiemetic for therapeutic interchange in December 2001. Promethazine use and adverse drug events (ADEs) were investigated following review of a serious ADE that identified promethazine use as a probable contributing factor. OBJECTIVE: To illustrate ADEs associated wi

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Alshweiat, Areen, Rita Ambrus, and IIdikó Csóka. "Intranasal Nanoparticulate Systems as Alternative Route of Drug Delivery." Current Medicinal Chemistry 26, no. 35 (2019): 6459–92. http://dx.doi.org/10.2174/0929867326666190827151741.

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There is always a need for alternative and efficient methods of drug delivery. The nasal cavity can be considered as a non-invasive and efficient route of administration. It has been used for local, systemic, brain targeting, and vaccination delivery. Although many intranasal products are currently available on the market, the majority is used for local delivery with fewer products available for the other targets. As nanotechnology utilization in drug delivery has rapidly spread out, the nasal delivery has become attractive as a promising approach. Nanoparticulate systems facilitate drug trans

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Hu, Lang-Yue, Wen-Li Mi, Gen-Cheng Wu, Yan-Qing Wang, and Qi-Liang Mao-Ying. "Prevention and Treatment for Chemotherapy-Induced Peripheral Neuropathy: Therapies Based on CIPN Mechanisms." Current Neuropharmacology 17, no. 2 (2019): 184–96. http://dx.doi.org/10.2174/1570159x15666170915143217.

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Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a progressive, enduring, and often irreversible adverse effect of many antineoplastic agents, among which sensory abnormities are common and the most suffering issues. The pathogenesis of CIPN has not been completely understood, and strategies for CIPN prevention and treatment are still open problems for medicine. Objectives: The objective of this paper is to review the mechanism-based therapies against sensory abnormities in CIPN. Methods: This is a literature review to describe the uncovered mechanisms underlying CIPN and to pr

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Knodle, Ryan D., Catherine Bielick, Shana Burrowes, and Tamar F. Barlam. "1558. Injection Drug Use-Related Skin and Soft Tissue Infections Serve as Sentinel Events for Healthcare Utilization in a Vulnerable Population." Open Forum Infectious Diseases 7, Supplement_1 (2020): S779. http://dx.doi.org/10.1093/ofid/ofaa439.1738.

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Abstract Background Persons with injection drug use (IDU) can have frequent skin and soft tissue infections (SSTIs) and high healthcare utilization. We sought to examine whether IDU-related SSTIs are associated with an acceleration in disease course and increased healthcare utilization (a ‘sentinel event’) and may present an important opportunity for intervention. Methods We performed a retrospective chart review of patients with an emergency department (ED) visit or hospital admission due to an IDU-related SSTI between 10/1/2015 and 6/1/2019 to obtain information on demographics, microbiologi

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Mytelka, Daniel S., Saurabh P. Nagar, Yulia D’yachkova, et al. "Health Care Resource Utilization and Costs among Adult Patients with Advanced Soft Tissue Sarcoma: A Retrospective Medical Record Review in the United Kingdom, Spain, Germany, and France." Sarcoma 2018 (September 12, 2018): 1–13. http://dx.doi.org/10.1155/2018/2020591.

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Objective. To describe health care resource utilization and costs for patients with advanced soft tissue sarcoma (STS) in the United Kingdom (UK), Spain, Germany, and France. Methods. Physicians abstracted data for adult patients with a diagnosis of advanced STS (other than Kaposi’s sarcoma or gastrointestinal stromal tumor) who received ≥1 lines of systemic therapy. Health care resource utilization related to advanced STS treatment was recorded; associated costs were estimated by applying unit costs. Results. A total of 130 physicians provided data for 807 patients (UK: 199; Spain: 203; Germa

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Gowda, D. V., M. Afrasim, S. I. Meenakshi, et al. "A Paradigm Shift in the Development of Anti-Candida Drugs." Current Topics in Medicinal Chemistry 19, no. 28 (2019): 2610–28. http://dx.doi.org/10.2174/1568026619666191029145209.

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Background: The considerable increase in the incidence of Candida infection in recent times has prompted the use of numerous antifungal agents, which has resulted in the development of resistance towards various antifungal agents. With rising Candida infections, the need for design and development of novel antifungal agents is in great demand. However, new therapeutic approaches are very essential in preventing the mortality rate and improving the patient outcome in those suffering from Candida infections. Objective: The present review objective is to describe the burden, types of Candidiasis,

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