Thematische Bibliographien / E2ES

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Auswahl der wissenschaftlichen Literatur zum Thema „E2ES“

Autor: Grafiati

Veröffentlicht am 1. April 2023

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Zeitschriftenartikel zum Thema "E2ES"

Chen, Shengyang, Weifeng Zhou, An-Shik Yang, Han Chen, Boyang Li und Chih-Yung Wen. „An End-to-End UAV Simulation Platform for Visual SLAM and Navigation“. Aerospace 9, Nr. 2 (19.01.2022): 48. http://dx.doi.org/10.3390/aerospace9020048.

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Visual simultaneous localization and mapping (v-SLAM) and navigation of unmanned aerial vehicles (UAVs) are receiving increasing attention in both research and education. However, extensive physical testing can be expensive and time-consuming due to safety precautions, battery constraints, and the complexity of hardware setups. For the efficient development of navigation algorithms and autonomous systems, as well as for education purposes, the ROS-Gazebo-PX4 simulator was customized in-depth, integrated into our previous released research works, and provided as an end-to-end simulation (E2ES) solution for UAV, v-SLAM, and navigation applications. Unlike most other similar works, which can only stimulate certain parts of the navigation algorithms, the E2ES platform simulates all of the localization, mapping, and path-planning kits in one simulator. The navigation stack performs well in the E2ES test bench with the absolute pose errors of 0.3 m (translation) and 0.9 degree (rotation), respectively, for an 83 m length trajectory. Moreover, the E2ES provides an out-of-box, click-and-fly autonomy in UAV navigation. The project source code is opened for the benefit of the research community.

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Sgheri, Luca, Claudio Belotti, Maya Ben-Yami, Giovanni Bianchini, Bernardo Carnicero Dominguez, Ugo Cortesi, William Cossich et al. „The FORUM end-to-end simulator project: architecture and results“. Atmospheric Measurement Techniques 15, Nr. 3 (03.02.2022): 573–604. http://dx.doi.org/10.5194/amt-15-573-2022.

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Abstract. FORUM (Far-infrared Outgoing Radiation Understanding and Monitoring) will fly as the ninth ESA's Earth Explorer mission, and an end-to-end simulator (E2ES) has been developed as a support tool for the mission selection process and the subsequent development phases. The current status of the FORUM E2ES project is presented together with the characterization of the capabilities of a full physics retrieval code applied to FORUM data. We show how the instrument characteristics and the observed scene conditions impact on the spectrum measured by the instrument, accounting for the main sources of error related to the entire acquisition process, and the consequences on the retrieval algorithm. Both homogeneous and heterogeneous case studies are simulated in clear and cloudy conditions, validating the E2ES against appropriate well-established correlative codes. The performed tests show that the performance of the retrieval algorithm is compliant with the project requirements both in clear and cloudy conditions. The far-infrared (FIR) part of the FORUM spectrum is shown to be sensitive to surface emissivity, in dry atmospheric conditions, and to cirrus clouds, resulting in improved performance of the retrieval algorithm in these conditions. The retrieval errors increase with increasing the scene heterogeneity, both in terms of surface characteristics and in terms of fractional cloud cover of the scene.

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Zhou, Tianbiao, Hongyan Li, Hongzhen Zhong, Zhiqing Zhong und Shujun Lin. „Association of apoE gene polymorphisms with lipid metabolism in renal diseases“. African Health Sciences 20, Nr. 3 (07.10.2020): 1368–81. http://dx.doi.org/10.4314/ahs.v20i3.43.

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Background and Objectives: Apolipoprotein E (apoE) plays a central role in the metabolism and homeostasis of lipids. ApoE gene encodes three major isoforms: ε2, ε3 and ε4 forming six phenotypes: Ε2Ε2, Ε2Ε3, Ε2Ε4, Ε3Ε3, Ε3Ε3 and Ε4Ε4 . Disorders of the lipid metabolism and the homeostasis are frequently coexist in renal diseases. The association be- tween gene polymorphisms of apoE and lipid metabolism were not consistent. This meta-analysis was performed to assess the association between gene polymorphisms of apoE and lipid metabolism in renal diseases. Methods: A pre-defined literatures search and selection of eligible relevant investigations were performed to extract and collect data from electronic databases. Results: Sixteen articles were enrolled for the analysis of association between apoE gene polymorphisms and lipid metab- olism. Subjects with E3E4 had a higher total cholesterol (TC) than those with E3E3, and subjects with E2E3 had a lower TC than those with E3E3. Subjects with ε2, ε3 had a lower TC than those with ε2, ε3 or ε4 , and subjects with ε4 had a higher TC than those with ε2, ε3 . Subjects with E2E2, E2E3 or E4E4 had a higher triglyceride (TG) than those with E3E3. Subjects with ε4 had a higher TG than those with ε2, ε3 . Subjects with ε2, ε3 had a higher level of TG than those with non-ε2, ε3 . Subjects with E3E4 had a slightly lower high-density lipoprotein (HDL) than those with E3E3. E3E4 appeared to be associated with lower levels of HDL. Subjects with E2E2, E2E3 had a notably lower low-density lipoprotein (LDL) than those with E3E3. Subjects with ε2, ε3 had a lower LDL than those with ε2, ε3 or ε4 ApoE gene polymorphisms were not associated with very low-density lipoprotein, and lipoprotein (a) [Lp(a)]. Subjects with E2E3 or E2E4 had higher apoE levels than those with E3E3, and subjects with E4E4 had lower apoE levels than those with E3E3. Conclusion: ApoE gene polymorphisms are associated with the expression of TC, TG HDL, LDL, Lp(a) or apoE. Keywords: Apolipoprotein E (ApoE) ; gene polymorphism; total cholesterol (TC) ;triglyceride (TG), high-density lipopro- tein (HDL); low-density lipoprotein (LDL); very low-density lipoprotein (VLDL); lipoprotein (a) [Lp(a)] • Meta-analysis

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Hoover, Kacie E., John R. Mecikalski, Timothy J. Lang, Xuanli Li, Tyler J. Castillo und Themis Chronis. „Use of an End-to-End-Simulator to Analyze CYGNSS“. Journal of Atmospheric and Oceanic Technology 35, Nr. 1 (Januar 2018): 35–55. http://dx.doi.org/10.1175/jtech-d-17-0036.1.

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AbstractTropical convection during the onset of two Madden–Julian oscillation (MJO) events, in October and December of 2011, was simulated using the Weather Research and Forecasting (WRF) Model. Observations from the Dynamics of the MJO (DYNAMO) field campaign were assimilated into the WRF Model for an improved simulation of the mesoscale features of tropical convection. The WRF simulations with the assimilation of DYNAMO data produced realistic representations of mesoscale convection related to westerly wind bursts (WWBs) as well as downdraft-induced gust fronts. An end-to-end simulator (E2ES) for the Cyclone Global Navigation Satellite System (CYGNSS) mission was then applied to the WRF dataset, producing simulated CYGNSS near-surface wind speed data. The results indicated that CYGNSS could detect mesoscale wind features such as WWBs and gust fronts even in the presence of simulated heavy precipitation. This study has two primary conclusions as a consequence: 1) satellite simulators could be used to examine a mission’s capabilities for accomplishing secondary tasks and 2) CYGNSS likely will provide benefits to future tropical oceanic field campaigns that should be considered during their planning processes.

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Polge, Cécile, Julien Aniort, Andrea Armani, Agnès Claustre, Cécile Coudy-Gandilhon, Clara Tournebize, Christiane Deval et al. „UBE2E1 Is Preferentially Expressed in the Cytoplasm of Slow-Twitch Fibers and Protects Skeletal Muscles from Exacerbated Atrophy upon Dexamethasone Treatment“. Cells 7, Nr. 11 (16.11.2018): 214. http://dx.doi.org/10.3390/cells7110214.

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Skeletal muscle mass is reduced during many diseases or physiological situations (disuse, aging), which results in decreased strength and increased mortality. Muscle mass is mainly controlled by the ubiquitin-proteasome system (UPS), involving hundreds of ubiquitinating enzymes (E2s and E3s) that target their dedicated substrates for subsequent degradation. We recently demonstrated that MuRF1, an E3 ubiquitin ligase known to bind to sarcomeric proteins (telethonin, α-actin, myosins) during catabolic situations, interacts with 5 different E2 enzymes and that these E2-MuRF1 couples are able to target telethonin, a small sarcomeric protein, for degradation. Amongst the E2s interacting with MuRF1, E2E1 was peculiar as the presence of the substrate was necessary for optimal MuRF1-E2E1 interaction. In this work, we focused on the putative role of E2E1 during skeletal muscle atrophy. We found that E2E1 expression was restricted to type I and type IIA muscle fibers and was not detectable in type IIB fibers. This strongly suggests that E2E1 targets are fiber-specific and may be strongly linked to the contractile and metabolic properties of the skeletal muscle. However, E2E1 knockdown was not sufficient for preserving the protein content in C2C12 myotubes subjected to a catabolic state (dexamethasone treatment), suggesting that E2E1 is not involved in the development of muscle atrophy. By contrast, E2E1 knockdown aggravated the atrophying process in both catabolic C2C12 myotubes and the Tibialis anterior muscle of mice, suggesting that E2E1 has a protective effect on muscle mass.

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Kurnianto, Aditya, Retnaningsih Retnaningsih, Dodik Tugasworo, Yovita Andhitara, Rahmi Ardhini und Jethro Budiman. „Apolipoprotein E Polymorphism and Carotid Intima Medial Thickness Progression in Post Ischemic Stroke Patient“. Medica Hospitalia : Journal of Clinical Medicine 9, Nr. 2 (30.07.2022): 154–61. http://dx.doi.org/10.36408/mhjcm.v9i2.750.

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Background : Apolipoprotein E (APOE) gene is believed to associate with cholesterol level, a risk factor of ischemic stroke. CIMT (carotid intima-media thickness) can be used to determine the degree of atherosclerosis. Increased CIMT may predict ischemic stroke recurrence. This study aimed to determine association between increased CIMT in post ischemic stroke patients and APOE genotype. Methods : This was an epidemiological prospective study involving 71 post ischemic stroke patients (1 month from onset), admitted from 2012 to 2013. CIMT was examined with carotid duplex ultrasound at 1st, 6th, and 12nd month after stroke onset. APOE gene polymorphism was examined using HRM (high-resolution melting) which is a simple method, accurate, and sensitive for genotyping. Results : We found 5 APOE gene variation categories, i.e. E2E3, E2E4, E3E3, E3E4, and E4E4. The most common allele was E3 and genotype groups E3E3 was the majority of the population. E2E4 allele had the highest CIMT level among others, in the 1st month, 6th month, and 12nd month after stroke, with no association with hypertension, diabetes, and hypercholesterolemia. E3E3 allele was most often associated with hypertension, diabetes mellitus, dyslipidemia, and hyperhomocysteinemia. Conclusion : The results showed that APOE genotype E2E4 may independently constitute risk factor for atherosclerosis progression (CIMT) in post ischemic stroke patients. While the E3E3 genotype was often associated with hypertension, diabetes mellitus, dyslipidemia, and hyperhomocysteinemia. Our results suggest that APOE E4 was not an important risk factor for carotid atherosclerosis in post ischemic stroke patient.

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Kuo, Chia-Ling, Luke C. Pilling, George A. Kuchel und David Melzer. „APOE2 AND AGING-RELATED OUTCOMES IN 261,000 UK BIOBANK OLDER ADULTS“. Innovation in Aging 3, Supplement_1 (November 2019): S221—S222. http://dx.doi.org/10.1093/geroni/igz038.811.

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Abstract ApoeE2 (e2) has both protective and adverse effects on health outcomes, which needs to be considered when targeting e2. We aimed to understand the role of e2 in aging via associations between e2 and a selection of aging traits using UK older adults of European descent. e2e3 (n=32,262) and e2e2 (n=1,629) were compared to e3e3 (n=153,567), adjusted for sex, age, genotyping arrays, assessment centers, and the first five genetic principal components. We found that e2 was associated with both parents top 10% survival (OR=1.14, 95% CI: 1.06-1.24), reduced risks of hypertension (OR=0.93, 95% CI: 0.91-0.96) and coronary heart disease (OR=0.86, 95% CI: 0.82-0.89), but red cell width distribution above the reference range (OR=1.17, 95% CI: 1.09-1.26). Additionally, e2 was minimally associated with frailty, cognitive function, and physical measures, suggesting that its association with parental extreme longevity may be controlled by mechanisms underlying diseases.

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de Oliveira, Johnatt Allan Rocha, Paula de Paula Menezes Barbosa und Gabriela Alves Macêdo. „High Concentrate Flavonoids Extract from Citrus Pomace Using Enzymatic and Deep Eutectic Solvents Extraction“. Foods 11, Nr. 20 (14.10.2022): 3205. http://dx.doi.org/10.3390/foods11203205.

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This paper evaluated methodologies for extracting phenolic compounds by DES (Deep eutectic solvents) associated with pectinlyase. Citrus pomace was characterized chemically, and seven DESs were formulated for extraction. Two groups of extractions were performed. Group 1 extractions were performed only with DESs, at 40 °C and 60 °C, with CPWP (Citrus pomace with pectin) and CPNP (Citrus pomace no pectin). In group 2, the DES was associated with pectinlyase and used only with CPWP at 60 °C in two ways of extraction: E1S (one-step extraction) and E2E (2-step extraction). The extracts were evaluated TPC (total phenolic compounds), individual phenolic compounds by HPLC, and antioxidant capacity by methodologies of DPPH and FRAP. The results of group 1 extractions for CPWP showed the highest phenolic compounds concentration (559.2 ± 2.79 mg/100 g DM) at 60 °C. Group 2 (E2S) showed high values of total phenolic compounds (615.63 ± 28.01 mg/100 g DM) and antioxidant activity (23,200 ± 721.69 µmol TE/g DM), with values higher than conventional extraction (545.96 ± 26.80 mg/100 g DM and 16,682.04 ± 2139 µmol TE/g DM). The study demonstrated the excellent extractive potential of DES for flavonoid extraction from citrus pomace. DES 1 and 5 by E2S showed the highest phenolic compounds and antioxidant capacity values, mainly when associated with pectinlyase.

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Fajas, Lluis, Rebecca L. Landsberg, Yolande Huss-Garcia, Claude Sardet, Jacqueline A. Lees und Johan Auwerx. „E2Fs Regulate Adipocyte Differentiation“. Developmental Cell 3, Nr. 1 (Juli 2002): 39–49. http://dx.doi.org/10.1016/s1534-5807(02)00190-9.

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Gupta, Tushar, Maria Teresa Sáenz Robles und James M. Pipas. „Cellular Transformation of Mouse Embryo Fibroblasts in the Absence of Activator E2Fs“. Journal of Virology 89, Nr. 9 (25.02.2015): 5124–33. http://dx.doi.org/10.1128/jvi.03578-14.

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ABSTRACTThe E2F family of transcription factors, broadly divided into activator and repressor E2Fs, regulates cell cycle genes. Current models indicate that activator E2Fs are necessary for cell cycle progression and tumorigenesis and are also required to mediate transformation induced by DNA tumor viruses. E2Fs are negatively regulated by the retinoblastoma (RB) family of tumor suppressor proteins, and virus-encoded oncogenes disrupt the RB-E2F repressor complexes. This results in the release of activator E2Fs and induction of E2F-dependent genes. In agreement, expression of large tumor T antigens (TAg) encoded by polyomaviruses in mammalian cells results in increased transcriptional levels of E2F target genes. In addition, tumorigenesis induced by transgenic expression of simian virus 40 (SV40) TAg in choroid plexus or intestinal villi requires at least one activator E2F. In contrast, we show that SV40 TAg-induced transformation in mouse embryonic fibroblasts is independent of activator E2Fs. This work, coupled with recent studies showing that proliferation in stem and progenitor cells is independent of activator E2Fs, suggests the presence of parallel pathways governing cell proliferation and tumorigenesis.IMPORTANCEThe RB-E2F pathway is altered in many cancers and is also targeted by DNA tumor viruses. Viral oncoprotein action on RBs results in the release of activator E2Fs and upregulation of E2F target genes; thus, activator E2Fs are considered essential for normal and tumorigenic cell proliferation. However, we have observed that SV40 large T antigen can induce cell proliferation and transformation in the absence of activator E2Fs. Our results also suggest that TAg action on pRBs regulates both E2F-dependent and -independent pathways that govern proliferation. Thus, specific cell proliferation pathways affected by RB alterations in cancer may be a factor in tumor behavior and response to therapy.

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Dissertationen zum Thema "E2ES"

Sandy, April R. „The role of E2Fs in mammary gland development“. Connect to resource, 2006. http://hdl.handle.net/1811/6624.

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Thesis (Honors)--Ohio State University, 2006.
Title from first page of PDF file. Document formatted into pages: contains 17 p.; also includes graphics. Includes bibliographical references (p. 16-17). Available online via Ohio State University's Knowledge Bank.

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Chen, Hui-Zi. „Mammalian Atypical E2Fs Link Endocycle Control to Cancer“. The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1316540844.

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Rakijas, Jessica B. „E2Fs and Transcription: New Members Help Answer Old Questions“. The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1492780032915208.

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Sun, Daokun. „E2F Proteins Regulate Cell Proliferation and Differentiation in Development“. The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1562695239955401.

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Docquier, Aurélie. „Rôle du corégulateur transcriptionnel RIP140 dans la signalisation par les facteurs E2Fs“. Thesis, Montpellier 1, 2010. http://www.theses.fr/2010MON1T018.

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Le contrôle du cycle cellulaire, processus fondamental pour la prolifération cellulaire, est souvent altéré au cours de la tumorigenèse. Les facteurs de transcription E2Fs sont des régulateurs majeurs de l'expression de gènes impliqués dans le cycle cellulaire, la réplication de l'ADN, la mort cellulaire programmée ou encore la différenciation cellulaire. La famille des facteurs E2Fs contient des membres qui agissent comme activateurs ou répresseurs de la transcription et dont l'activité est régulée par un grand nombre de corégulateurs transcriptionnels, incluant notamment les protéines à poche pRb, p107, p130. RIP140 (Receptor Interacting Protein of 140kDa) a été identifié comme un corépresseur de nombreux récepteurs nucléaires, une autre grande famille de facteurs de transcription qui, pour certains, régulent positivement l'expression du gène RIP140.Ce travail de thèse a permis d'identifier RIP140 comme un nouveau répresseur de l'activité transcriptionnelle du facteur E2F1, dans des expériences de transfection transitoire ainsi que sur l'expression de gènes endogènes. Nous avons également montré que l'expression ectopique de RIP140 bloque la progression des cellules dans le cycle cellulaire. Dans les cancers du sein, le niveau d'expression de RIP140 présente une corrélation inverse avec celui de différents gènes cibles des facteurs E2Fs et semble discriminer les tumeurs luminales des tumeurs basales. Nous avons également démontré que le niveau d'ARNm RIP140 est régulé au cours du cycle cellulaire et que le promoteur du gène RIP140 est une cible directe des facteurs E2Fs. Cette régulation implique des sites de liaison des facteurs E2Fs et Sp1 de la région proximale du promoteur. La régulation de ce gène par E2F1 a également été observée au cours du processus de différenciation adipocytaire en utilisant un modèle murin E2F1-/-.En conclusion, ce travail a permis d'identifier RIP140 comme un nouvel acteur de la voie de signalisation par les facteurs E2Fs
Cell cycle control, a fundamental process which controls cell proliferation, is frequently altered during tumorigenesis. The E2F transcription factors are central regulators of target gene expression involved in cell cycle regulation, DNA replication, apoptosis and differentiation. The E2F transcription factors family encompasses members which act as activators or repressors. Their activities are regulated by a large number of transcriptional coregulators, including in particular the pocket proteins pRb, p107, p130.The transcription coregulator RIP140 (Receptor Interacting Protein of 140kDa) has been identified as a partner of numerous nuclear receptors, another important transcription factor family. Some of these nuclear receptors positively regulate RIP140 gene expression.This work identified RIP140 as a new repressor of E2F1 transcriptional activity, both in transient transfection experiments and on the expression of endogenous target genes. We also showed that ectopic expression of RIP140 blocks cell cycle progression. In breast cancers, the level of RIP140 expression is inversely correlated with various target genes of E2Fs factors and seems to discriminate luminal from basal tumors. We also demonstrated that the RIP140 mRNA expression is regulated during cell cycle and that the RIP140 promoter is a direct target of E2F transcription factors. This regulation involves both E2F and Sp1 binding sites in the proximal region of the RIP140 promoter. The regulation of the RIP140 gene by E2F1 was also observed during adipocyte differentiation using an E2F1-/- mouse model.In conclusion, this study identified RIP140 as a new regulator of the E2F signalling pathway and as a novel E2F1 target gene. These results open new perspectives concerning the roles that this transcriptional coregulator might play in the control of cell proliferation and tumorigenesis

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Yampolskiy, Mark. „Maßnahmen zur Sicherung von E2E-QoS bei Verketteten Diensten“. Diss., kostenfrei, 2009. http://edoc.ub.uni-muenchen.de/10971/.

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Gemae, Raghda. „The Role of Activating E2Fs in Neural Stem Cell Maintenance from Development to Adulthood“. Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/35587.

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The recent discovery of adult neural precursor cells (NPCs) in the dentate gyrus and the subventricular zone of the lateral ventricles of most mammals holds much hope for the potential regeneration of damaged brain tissue. However, their use has been limited by their low numbers and relatively quiescent state, particularly in the aging brain. Previous studies from our laboratory have demonstrated a crucial role for the Rb/E2F pathway in the regulation and proliferation of NPCs, and the direct mechanistic involvement of E2F3 in regulating the pluripotency factor, Sox2. More recently, our investigations into the roles of E2F1 and E2F3 in during adult neurogenesis have revealed that loss of both these genes results in a dramatic loss of adult NPCs. Here, we have employed the Emx1-Cre and Nestin-CreERT2 transgenic models, to specifically delete E2F1 and E2F3 in the cerebral cortex and in NPCs in order to investigate the role of both these genes in embryonic neurogenesis. Our results suggest a switch in the requirement for both E2Fs 1 and 3 between embryonic and adult NPCs, demonstrated by a decrease in NPC proliferation and numbers starting only during late embryonic development and persisting through postnatal neurogenesis. These findings suggest that E2Fs 1 and 3 are essential for the maintenance of stem cells and neurogenesis in the adult brain. Moreover, their deletion results in defects in learning and memory. These studies reveal a crucial role for activating E2Fs in the long-term maintenance and proliferation of neural stem cells.

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Yakubovich, Edward. „The Role of Activator E2Fs in Neural Stem Cell Activation and Exit from Quiescence“. Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/39437.

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Regenerative medicine offers tremendous potential for the treatment of irreversible damage to the brain. Activation of quiescent adult neural stem cells by clinical means to regenerate tissue can improve pathological outcomes of patients afflicted by brain trauma. Control of the cell- cycle is important in activating quiescent neural stem cells for the purpose of enhancing adult neurogenesis. Here, we uncover the role of cell-cycle regulatory transcription factors E2F1 and E2F3 in adult neural stem cell activation and characterize it. We hypothesize that the Retinoblastoma-E2F pathway is crucial for neural stem cell activation. We characterized the requirement of E2Fs1/3 for adult neural stem cells activation through a combination of multiple knockout timepoints in mice and novel markers used to identify distinct neural stem cell sub- populations. The results show a marked reduction in the neurogenic capacity of the adult brain, with common markers of proliferation and different progenitor-cell lineages decreased. Additionally, the ability of quiescent neural stem cells to transition to an active state is reduced. A whole genome-analysis of RNA isolated from E2Fs1/3-knockout adult neural stem cells has shown a shift from an active identity-state to a quiescent one. In the future, E2Fs1/3 could emerge as key regulators of quiescent stem cell activation, and thus could be potential targets for therapeutic control in order to enhance neurogenesis in patients with brain pathology.

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Dugal-Tessier, Delphie. „The Role of Atypical E2fs in the Maintenance and Development of the Ependymal Cell Barrier“. Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/34454.

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The discovery of neural stem cells within the adult CNS has indicated an enormous potential in facilitating neuronal regeneration after injury. Studies from our laboratory have suggested that manipulation of the Rb/E2f pathway can directly impact embryonic and adult neurogenesis, thereby having tremendous potential for neuronal regeneration therapies. Recently, two new members of the Rb/E2f pathway have been discovered, the atypical E2fs: E2f7 and E2f8. Initial studies have suggested that atypical E2fs regulate diverse processes such as cell proliferation, DNA-stress response, apoptosis, however, their importance in the brain are unknown. To analyze their function during brain development, we crossed Nestin-Cre mice with mice bearing a conditional E2f7/E2f8 allele to delete both E2f7 and E2f8 in neural precursor cells. Whereas cortical development was largely unaffected by E2f7/E2f8 deficiency, we observed an enlargement of the lateral ventricles occurring postnatally, a brain condition named ventriculomegaly. We then looked at the ependymal cells, which are the cells lining the wall of the lateral ventricles, to determine if these cells were affected by the absence of atypical E2fs. We found progressive denaturation of the ependymal cell layer, distortion of the ependymal motile cilia and reactive astrocytes within the layer. We identified Gli3, a component of the Sonic hedgehog pathway (Shh), as a target for E2fs, including atypical E2fs. We unravelled a novel mechanism by which atypical E2fs regulate the expression of Gli3, leading to up-regulation of Numb/NumbL, which in consequence destabilizes cadherins organization within the ependymal cell layer. In conclusion, our work suggests that E2f7 and E2f8 transcription factors play an essential role in maintaining the ependymal cell barrier.

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Stevenson, Amadeus. „Interactions of nanoparticles with cells for nanomedical applications“. Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:ecde4b01-e2ec-42f4-9353-72071b845775.

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Nanotechnology is a rapidly growing field focused on the manipulation and control of materials with dimensions under 100 nm. The novel electronic, optical and mechanical properties observed at the nanoscale have resulted in a number of applications in catalysis, light emitting devices, solar power, self-cleaning surfaces and medicine. Medical applications of nanotechnology (“nanomedicine”) are particularly promising for rapid clinical diagnosis and targeted treatments. Understanding the interactions of nanoparticles with living matter is of fundamental importance for all application areas: manufacture, use and disposal of the growing number of nanoproducts will result in increased environmental exposure in addition to direct exposure through nanomedical applications. However, there is a lack of standard methodologies for assessing these interactions. In this work the stability of silver-based nanoparticles was established by UV- Visible (UV-Vis) spectroscopy, atomic force microscopy (AFM) and transmission electron microscopy (TEM). The presence of a higher valence metal or polymer on the nanoparticle surface was demonstrated to improve stability. A standard methodology was developed to study nanoparticle-cell interactions: an “atlas” of the effects of known drugs on a cell is created, and compared with the effects of a nanoparticle. Escherichia coli was selected as a model organism and the effects of a range of antibiotics were characterised through a combination of microbiological assays and AFM. Susceptibility, population cell growth and individual heights, widths, lengths and volumes of bacteria were obtained on a 2% agarose substrate in air. The methodology was applied and adjusted for silver nanoparticles due to the interactions of silver with the bacterial growth medium. 10 and 30 nm silver nanoparticles and ions were found to kill E. coli through an internal mechanism of action, with a size-specific effect on the height of bacteria. Finally, a novel AFM characterisation method is described to examine the mechanical properties of live bacterial and human cells in liquid.

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Bücher zum Thema "E2ES"

E2E4: [stikhi]. [Moskva: Izdatelʹ A.D. Bogatykh], 2005.

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Commission, Victoria Essential Services. End-to-end project issues paper: E2E issues paper. Melbourne: Essential Services Commission, 2005.

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e2e. e2e, 2020.

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Greve, Tom. Reptiles (E2E). Rourke Educational Media, 2011.

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Mccleese, Don. Insects (E2E). Rourke Educational Media, 2011.

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Mcleese, Don. Gorillas (E2E). Rourke Educational Media, 2010.

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All E2e. Independently Published, 2021.

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Oppliger, Rolf. E2EE Messaging on the Internet. Artech House, 2020.

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Careers train: Supporting careers work in work based learning and e2e. Stafford: HighFlyers Publishing Ltd., 2003.

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Buchteile zum Thema "E2ES"

Gramaglia, Marco, Alexandros Kaloxylos, Panagiotis Spapis, Xavier Costa, Luis Miguel Contreras, Riccardo Trivisonno, Gerd Zimmermann, Antonio de la Oliva, Peter Rost und Patrick Marsch. „E2E Architecture“. In 5G System Design, 79–114. Chichester, UK: John Wiley & Sons, Ltd, 2018. http://dx.doi.org/10.1002/9781119425144.ch5.

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Dusane, Suprit, Md Iliyaz und A. Suresh. „Implementation of E2EE Using Python“. In Advances in Intelligent Systems and Computing, 635–42. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-4676-9_55.

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Sardet, Claude, Laurent LeCam, Eric Fabbrizio und Marc Vidal. „E2Fs and the Retinoblastoma Protein Family“. In Oncogenes as Transcriptional Regulators, 1–62. Basel: Birkhäuser Basel, 1997. http://dx.doi.org/10.1007/978-3-0348-8934-6_1.

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Rura, Lauretha, Biju Issac und Manas Haldar. „Vulnerability Studies of E2E Voting Systems“. In Lecture Notes in Electrical Engineering, 223–31. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-06773-5_30.

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Paul, Ray, Wei-Tek Tsai, Bing Li und Xiaoying Bai. „XML-based E2E Test Report Management“. In Conceptual Modeling — ER 2001, 607–8. Berlin, Heidelberg: Springer Berlin Heidelberg, 2001. http://dx.doi.org/10.1007/3-540-45581-7_47.

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Kelsey, John, Andrew Regenscheid, Tal Moran und David Chaum. „Attacking Paper-Based E2E Voting Systems“. In Towards Trustworthy Elections, 370–87. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-12980-3_23.

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Frajtak, Karel, und Tomas Cerny. „On Persistent Implications of E2E Testing“. In Enterprise Information Systems, 326–38. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-08965-7_16.

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Zhang, Lei, und Le Chen. „Building E2E Security for Cloud DCNs“. In Cloud Data Center Network Architectures and Technologies, 263–312. First edition. | Boca Raton : CRC Press, 2021. | Summary: “This book has: CRC Press, 2021. http://dx.doi.org/10.1201/9781003143185-8.

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Lu, Yue, Fernando Kuipers, Milena Janic und Piet Van Mieghem. „E2E Blocking Probability of IPTV and P2PTV“. In NETWORKING 2008 Ad Hoc and Sensor Networks, Wireless Networks, Next Generation Internet, 445–56. Berlin, Heidelberg: Springer Berlin Heidelberg, 2008. http://dx.doi.org/10.1007/978-3-540-79549-0_39.

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de Marneffe, Olivier, Olivier Pereira und Jean-Jacques Quisquater. „Simulation-Based Analysis of E2E Voting Systems“. In Lecture Notes in Computer Science, 137–49. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-77493-8_12.

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Konferenzberichte zum Thema "E2ES"

Zhang, Xu, Siddhartha Sen, Daniar Kurniawan, Haryadi Gunawi und Junchen Jiang. „E2E“. In SIGCOMM '19: ACM SIGCOMM 2019 Conference. New York, NY, USA: ACM, 2019. http://dx.doi.org/10.1145/3341302.3342089.

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Irani, Mazda, Sahar Ghannadi, Nick Daprocida Nick Daprocida, Pierre Lacoste-Bouchet und Vince DiStefano. „On Numerical Modelling of the Hydraulic-Fractured Closed Loop Systems: Single Producer“. In SPE Canadian Energy Technology Conference. SPE, 2022. http://dx.doi.org/10.2118/208945-ms.

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Abstract There are large regions of the subsurface where the temperature is sufficiently hot to generate geothermal electricity within reasonable drilling depths, but the formation does not have enough permeability to create heated water productivity. The primary bottleneck is the difficulty of achieving adequate flow rate in such geothermal reservoirs. These formations are referred as hard dry rock (HDR). In these formations two common applications are conducted: Enhanced (or Engineered) geothermal systems (EGS) and Advanced geothermal systems (AGS). AGS is a closed-loop system that are built on wells drilled that connect with each other allowing a heat exchange-type to set up beneath the surface. There has recently been a lot of attention to the concept of ‘closed-loop geothermal’. The concept is still evolving and few startups such as E2E Energy Solutions, Eavor Technologies, and Green Fire Energy suggested different types of the closed-loop to optimize the technology. Since the technology only relies on conduction as the only source of heat transfer to improve the economics of the closed-loop E2E Energy Solutions suggested to use the hydraulic fracture to increase the surface area between the well and the geothermal reservoir. Such process is called Enhanced Geothermal Reservoir Recovery System (EGRRS). In the E2E's EGRRS process, a fluid would be produced from an existing hot subterranean aquifer reservoir, close to a favorable geothermal zone, instead of creating the whole loop from the surface. The fluid withdrawn from a hot subterranean reservoir would be contacted with a hydraulically fractured zone in the geothermal zone, which would result to additional energy transfer and therefore a higher enthalpy once the fluid reaches the surface. The plan is to reach temperatures above 200°C that greatly increasing the electrical generation potential. Although to implement the EGRRS process we are using the common oil and gas practice but to optimize and design the process using current modelling techniques is not achievable. Current simulation schemes cannot model such complex system, and to resolve this, a new framework must be designed to resolve the challenge. In this paper we present a new method that calculate rate to each branch by a new iterative approach that resolve the problem on how fractions of different pipe should be solved. Since the closed-loop wells are connected to the subterranean aquifer reservoirs and operator required to keep the WHP at constant pressure, there is another layer of iteration that required to solve for fraction on each pipe and BHP at the aquifer. Finally, to model the heating in the fractured zone, a new resistance is added to the model to mimic the heating exchange between the fracture and the fluid? and also the fracture and the radiator formation.

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Lima, Mathews P. S., Charles H. F. Dos Santos, Felipe S. D. Silva und Augusto Venâncio Neto. „Avaliação da Performance de Estratégias de Decisão de Mobilidade MADM na Perspectiva da Eficiência de QoE“. In XXXVI Simpósio Brasileiro de Redes de Computadores e Sistemas Distribuídos. Sociedade Brasileira de Computação - SBC, 2018. http://dx.doi.org/10.5753/sbrc_estendido.2018.14636.

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O estado da arte na avaliação de gerenciamento de mobilidade orientada para a qualidade por meio de técnicas de decisão MADM apenas aborda as medidas dos níveis de Qualidade de Serviço (Quality of Service – QoS) dos pacotes das redes. Nesse sentido, este trabalho preenche esta lacuna através de uma ampla revisão dos métodos MADM aplicados ao processo de decisão de mobilidade orientada para a qualidade por meio da realização de uma avaliação de QoE, centrada no usuário, desses algoritmos em relação ao nosso trabalho anterior: o Extended Elitism for Best Selection (E2BS). A avaliação de QoE é conduzida por meio da ﬂexibilidade provida pelo paradigma de Redes Móveis Deﬁnidas por Software (Software-Deﬁned Mobile Networking – SDMN). Os resultados da análise QoE demonstram que o E2BS supera os métodos selecionados baseados em MADM, melhorando a QoE percebida pelos usuários móveis ao consumir ﬂuxos móveis multimídia.

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Kuster, Marc Wilhelm, Man-Sze Li, Christoph Ludwig und Pedro Malo. „E2ESU — stable foundations for digital business ecosystems“. In 2008 2nd IEEE International Conference on Digital Ecosystems and Technologies (DEST). IEEE, 2008. http://dx.doi.org/10.1109/dest.2008.4635183.

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Dušek, Ondřej, Jekaterina Novikova und Verena Rieser. „Findings of the E2E NLG Challenge“. In Proceedings of the 11th International Conference on Natural Language Generation. Stroudsburg, PA, USA: Association for Computational Linguistics, 2018. http://dx.doi.org/10.18653/v1/w18-6539.

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Araújo, Antonia Vanessa Dias, und Antonio Carlos de Oliveira Júnior. „Desafios no desenho do escopo arquitetônico 6G“. In Workshop de Redes 6G. Sociedade Brasileira de Computação, 2022. http://dx.doi.org/10.5753/w6g.2022.223486.

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Este artigo apresenta e discute os desafios de implementação das redes 6G, considerando seus requerimentos, cenários de uso, casos de usos e tecnologias habilitadoras. Apresenta ainda a visão dos autores quanto as premissas a serem consideradas no escopo da arquitetura de redes móveis 6G, e.g. Arquitetura Baseada em Serviços (SBA), Arquitetura Orientada por Mandato de ponta a ponta (MDA/E2E) e o paradigma de Redes auto-sustentáveis(SSN).

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Mostafa, Salama, Azizul Azhar Ramli, Mohammed Ahmed Jubair, Saraswathy Shamini Gunasekaran, Aida Mustapha und Mustafa Hamid Hassan. „Integrating Human Survival Factor in Optimizing the Routing of Flying Ad-hoc Networks in Search and Rescue Tasks“. In 13th International Conference on Applied Human Factors and Ergonomics (AHFE 2022). AHFE International, 2022. http://dx.doi.org/10.54941/ahfe1002523.

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Flying Ad-hoc Network (FANET)'s model operates according to routing protocols along with basic technical routing parameters. One of the FANET's significant challenges is ensuring the resilience of the UAVs' performance by adjusting the operational plan and network routing based on the constraints of operation goals and the limitations of resources. Subsequently, this paper proposes an agent-based Adaptive Zone Routing Protocol (AZRP) that enables the FANET to perform disaster relief missions efficiently. The AZRP operates in economic mode, search mode, or rescue mode according to the operational plan conditions, limitations of resources, and human survival factor. The AZRP is compared with the standard ZRP and AODV to determine the most suitable routing protocol in performing disaster relief missions. The search and rescue simulation is implemented by using the NS2 simulator. The testing and evaluation criteria consider Throughput (TH), Packet Delivery Ratio (PDR), Packet Loss Ratios (PLR), and End-to-End Delay (E2E Delay). The obtained results indicate that the FANET model is able to perform in the three modes effectively and optimizes the search and rescue operations according to the given disaster relief simulation context and constraints. The AZRP outperforms the other two protocols and is able to achieve higher TH, higher PDR, lower PLR, and lower E2E delay.

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Xilouris, G., T. Pliakas und A. Kourtis. „Enthrone Experimental Infrastructure for E2E QOS Provisioning“. In 2007 IEEE 18th International Symposium on Personal, Indoor and Mobile Radio Communications. IEEE, 2007. http://dx.doi.org/10.1109/pimrc.2007.4394016.

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Bag, Samiran, und Feng Hao. „E2E Verifiable Electronic Voting System for Shareholders“. In 2019 IEEE Conference on Dependable and Secure Computing (DSC). IEEE, 2019. http://dx.doi.org/10.1109/dsc47296.2019.8937711.

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Puzikov, Yevgeniy, und Iryna Gurevych. „E2E NLG Challenge: Neural Models vs. Templates“. In Proceedings of the 11th International Conference on Natural Language Generation. Stroudsburg, PA, USA: Association for Computational Linguistics, 2018. http://dx.doi.org/10.18653/v1/w18-6557.

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