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Thematische Bibliographien / Effect of chemicals on skin / Dissertationen

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Dissertationen zum Thema „Effect of chemicals on skin“

Autor: Grafiati

Veröffentlicht am 4. Juni 2021

Zuletzt aktualisiert am 20. Februar 2023

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1

Reed, Susan, of Western Sydney Hawkesbury University, and of Science Technology and Environment College. "Development of method to assess skin contact to chemicals." THESIS_CSTE_XXX_Reed_S.xml, 2001. http://handle.uws.edu.au:8081/1959.7/611.

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Chemical exposure of the skin has become a route of entry of some chemicals into the body and has come under major review in recent times. This research aims to develop a method of estimating skin exposure that is both reliable and non-prohibitive in cost. This involved the design and testing of skin patches adaptable for monitoring skin exposure to chemicals using several different types of absorbents which could be easily worn against skin. The final design of the patch used either activated charcoal or tenax as the absorbing medium. The patches were then desorbed with a solvent in order to

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2

Reed, Susan. "Development of method to assess skin contact to chemicals." Thesis, View thesis View thesis, 2001. http://handle.uws.edu.au:8081/1959.7/611.

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Chemical exposure of the skin has become a route of entry of some chemicals into the body and has come under major review in recent times. This research aims to develop a method of estimating skin exposure that is both reliable and non-prohibitive in cost. This involved the design and testing of skin patches adaptable for monitoring skin exposure to chemicals using several different types of absorbents which could be easily worn against skin. The final design of the patch used either activated charcoal or tenax as the absorbing medium. The patches were then desorbed with a solvent in order to

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3

Ibrahim, Sarah A. "A Structure-Enhancement Relationship and Mechanistic Study of Chemical Enhancers on Human Epidermal Membrane based on Maximum Enhancement Effect (Emax)." University of Cincinnati / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1266598335.

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4

Robson, Denise Lesley. "Buprenorphine hydrochloride permeation through human skin in vitro; the effect of chemical enhancement and iontophoresis : effect of pH, distribution ratio, penetration enhancers azone and oleyl alcohol, and iontophoresis on the permeation of buprenorphin." Thesis, University of Bradford, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.329293.

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5

Reed, Susan. "Development of method to assess skin contact to chemicals /." View thesis View thesis, 2001. http://library.uws.edu.au/adt-NUWS/public/adt-NUWS20030520.115134/index.html.

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Thesis (Ph.D.) -- University of Western Sydney, Hawkesbury, 2001.<br>A thesis presented in fulfilment of the requirement for the degree of Doctor of Philosophy, College of Science, Technology and Environment, University of Western Sydney, Richmond, April 2001. Bibliography : leaves 138-148.

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6

Tonge, Robert Patrick. "The cutaneous disposition of the sensitizing chemicals hydroxycitronellal and dinitrochlorobenzene." Thesis, Imperial College London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309531.

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7

McHugh, Peter J. "Sunlight-induced DNA damage in relation to sunscreening chemicals." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319052.

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8

Ashrafi, Parivash. "Predicting the absorption rate of chemicals through mammalian skin using machine learning algorithms." Thesis, University of Hertfordshire, 2016. http://hdl.handle.net/2299/17310.

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Machine learning (ML) methods have been applied to the analysis of a range of biological systems. This thesis evaluates the application of these methods to the problem domain of skin permeability. ML methods offer great potential in both predictive ability and their ability to provide mechanistic insight to, in this case, the phenomena of skin permeation. Historically, refining mathematical models used to predict percutaneous drug absorption has been thought of as a key factor in this field. Quantitative Structure-Activity Relationships (QSARs) models are used extensively for this purpose. How

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9

Bian, Junxing. "Skin permeation enhancement using chemical enhancers and polymeric microneedles for chemicals and peptides." Thesis, University of Sydney, 2020. https://hdl.handle.net/2123/23624.

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It is often a challenge to effectively deliver drugs through the skin into the internal environment. Compared with oral administration and other dosage forms, transdermal administration has multiple advantages. Among the various transdermal administration approaches, microneedles emerge as a powerful tool in recent years, owing to its simple concept and proven efficacy. In this project, we aim to develop a hot-embossing method using menthol as the carrier material to fabricate drug-laden microneedle patches. We compared the transdermal delivery of several drugs with different dosage forms and

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10

Lee, Su-Gil. "Dermal and ocular exposure during the spray application of selected industrial chemicals /." Title page, abstract and table of contents only Title page, abstract and table of contents only, 2004. http://web4.library.adelaide.edu.au/theses/09PH/09phl4770.pdf.

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11

Karsten, Aletta Elizabeth. "The effect of skin phototype on laser propagation through skin." Thesis, University of Pretoria, 2012. http://hdl.handle.net/2263/24272.

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The use of lasers for diagnosis and treatment in medical and cosmetic applications is increasing worldwide. Not all of these modalities are superficial and many require laser light to penetrate some distance into the tissue or skin to reach the treatment site. Human skin is highly scattering for light in the visible and near infrared wavelength regions, with a consequent reduction of the fluence rate. Melanin, which occurs in the epidermis of the skin, acts as an absorber in these wavelength regions and further reduces the fluence rate of light that penetrates through the epidermis to a treatm

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12

Horst, Joanna Horst. "Effect of Multiple Skin-to-Skin Experiences on Exclusive Breastfeeding Rates." ScholarWorks, 2017. https://scholarworks.waldenu.edu/dissertations/3612.

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Breastmilk feeding at birth demonstrates short- and long-term medical and neurodevelopmental advantages. Infants who are exclusively breastfed demonstrate less nausea, vomiting, and diarrhea, and they experience less upper respiratory and ear infections than do infants who are not breastfed. One strategy that supports breastfeeding initiation is providing skin-to-skin contact (STS) with mothers and newborns immediately upon birth. The purpose of this project was to evaluate the impact of a second session of STS on the postpartum unit on exclusive breastfeeding rates at discharge. A retrospecti

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13

Nanayakkara, Gihan Ravinda. "Some effects of schistosome cercarial secretions and chemical agents on the permeability of human skin." Thesis, King's College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.428044.

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14

Filby, Amy Louisa. "Molecular effect pathways of endocrine disrupting chemicals in fish." Thesis, University of Exeter, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.439828.

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15

BARAI, NAMRATA D. "EFFECT OF HYDRATION ON SKIN PERMEABILITY." University of Cincinnati / OhioLINK, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1016480955.

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16

Zhang, Weicheng. "Prediction of the skin sensitization potential of organic chemicals through in vitro bioassay and chemoassay information." Doctoral thesis, Technische Universitaet Bergakademie Freiberg Universitaetsbibliothek "Georgius Agricola", 2015. http://nbn-resolving.de/urn:nbn:de:bsz:105-qucosa-161710.

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Skin sensitization resulting for allergic contact dermatitis (ACD) is an occupational and environmental health issue. The allergic hazard for workers and consumers is a serious problem for individuals, employers and marketing certain products. Consequently, it is necessary to accurately identify chemicals skin sensitization potential. According to the new EU chemical regulation REACH (Registration, Evaluation, Authorization and Restriction of Chemicals), information of skin sensitization of chemicals manufactured or imported at or above 1 ton/year should be available. Currently, valid approach

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17

Arritt, Fletcher Marion. "Efficacy of Selected Chemicals on the Attachment and Survival of Campylobacter jejuni on Chicken Breast Skin." Thesis, Virginia Tech, 2000. http://hdl.handle.net/10919/31083.

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Campylobacter is considered to be the leading cause of acute bacterial gastroenteritis in humans in the United States with Campylobacter jejuni being responsible for 80-90% of those infections. Many cases of Campylobacter gastroenteritis have been linked to the consumption of raw or undercooked chicken. The population of bacteria on the breast skin has been reported to be greater than on other edible portions of the chicken carcass making this an important site to control the organism and to study bacterial attachment properties. This research examined the efficacy of trisodium phosphate (TS

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18

Tonolli, Paulo Newton. "Photosensitization of Lipofuscin in Skin Keratinocytes: Effect of Visible Light on Human Skin." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-12122018-114252/.

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Lipofuscin is an autofluorescent pigment progressively accumulated during cellular aging, in several tissues, such as heart, muscle and retina, especially in the postmitotic period. That phenomenon may result from oxidative stress, when biomolecules and organelles (mainly mitochondria) are damaged, generating non-degradable products inside lysosomes. Lipofuscin can be photosensitized, promoting photoxidative processes in cellular components. Many studies on lipofuscin were made using the human retinal pigment epithelial cells, but very little is known about lipofuscin from human skin. In this

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19

Chen, Andrew Chih-Chieh. "Effect of oral nicotinamide on non-melanoma skin cancer and skin barrier function." Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/15831.

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Exposure to ultraviolet radiation and immunosuppression are the principal causes of non-melanoma skin cancer (NMSC). One of the skin’s main functions is to act as a barrier against environmental insults and transepidermal water loss (TEWL) is a marker of skin barrier function. Previous phase 2 studies have shown nicotinamide (NAM) to reduce premalignant actinic keratoses. Topical NAM has been shown to reduce TEWL. The effects of oral NAM were evaluated in two clinical trials. The Oral Nicotinamide To Reduce Actinic Cancer (ONTRAC) study was a multicentre phase 3, double-blind, randomised contr

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20

Coberly, Samantha W. "The effect of household chemicals on deciduous and permanent tooth class." Thesis, Wichita State University, 2013. http://hdl.handle.net/10057/6807.

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Dental anthropology was wide ranging implications for the field of anthropology. Teeth have become important sources of data about the individual as well as possibly being able to identify them. One problem that can arise is the chemical destruction of teeth whether it be diagenesis in an archaeological context or deliberately in a forensic context. In terms of deliberate destruction of the body several household chemicals are cheap and easily assessable. The purpose of this research is to look at how six household chemicals affect both deciduous and permanent tooth classes. The six chemicals

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21

Turan, Nahid. "The effect of plasticisers and related chemicals on sulphate supply enzymes." Thesis, University of Birmingham, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433746.

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22

Delacruz, C. Ligia. "The effect of natural toxicants and other chemicals on the kidney." Thesis, University of Surrey, 1988. http://epubs.surrey.ac.uk/847359/.

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Repeated administration of ochratoxin A (OTA) caused renal morphological dose-related changes, that were associated with proximal tubular and glomerular damage the latter showing oedema and prominent PAS staining suggestive of glomerular basement membrane thickening. On the other hand, the combined administration of repeated doses of OTA and aflatoxin B[1] (2. 5 mg and 100 ug per kg, respectively), appeared to have a synergistic effect, characterized by severe disruption of proximal tubules and general morphological derrangement of the glomerulus, involving intense and faint staining nuclei (s

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23

Howard, Samuel Clarence. "The effect of three holding tank chemicals on anaerobic wastewater treatment." Thesis, Virginia Tech, 1988. http://hdl.handle.net/10919/45158.

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Sewage-holding tanks aboard recreational boats store human wastes, thereby preventing the direct discharge of wastewater to the aquatic environment. Water-conserving toilets and limited holding tank volumes produce a highly concentrated waste that must be periodically dumped to a wastewater treatment system. Prior to disposal, many boat operators add commercial preparations to control odors produced in their chemical toilets and holding tanks. The objective of this study was to determine the effects of three holding-tank chemicals on anaerobic wastewater treatment. Specifically, septic-tank pe

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24

Huaytia, Fernandez Ricardo. "Skin and proximity effect analysis of traction motor." Thesis, KTH, Elektrisk energiomvandling, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-96302.

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Traction motors are thermally pressed to obtain a high torque per unit volume at the same time as a relatively high frequency is used. Because of the high frequency the phenomenon skin effect and proximity effects appear, this is explored in the thesis. To find a link between the parasitic and thermal effects on the insulation is important. In this thesis, a finite element model of the Flux 2D suitable for skin effect analysis is developed; also a thermal network has been developed to find thermal hotspots in the stator slot. In this thesis, sinusoidal supplies for two operating points are stu

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25

Said, Dina. "Effect of Hand Hygiene Procedures on Skin Biomarkers." University of Cincinnati / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1146608923.

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26

Dinsmore, Kristen G., Bethany Campbell, Timothy Archibald, Greg Mosier, Stacy D. Brown, and Alexei Gonzalez-Estrada. "Refrigerated Stability of Diluted Cisatracurium, Rocuronium, and Vecuronium for Skin Testing after Perioperative Anaphylaxis." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/etsu-works/5266.

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RATIONALE: The purpose of this study is to investigate the stored stability of dilutions of neuromuscular blocking agents (NMBAs), namely cisatracurium, rocuronium, and vecuronium, for skin prick/intradermal testing. METHODS: Concentrations of NMBAs were monitored by liquid chromatography-mass spectrometry (LC-MS/MS) for a period of 14 days. Dilutions of NMBAs were prepared in saline by factors of 10x, 100x, 1,000x, and 100,000x as sensitivity of the assay allowed. Diluted drug products were stored in a laboratory refrigerator until sampling. On sampling days, aliquots of each dilution were re

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27

Li, Jing Adela, and 李晶. "Temperature-dependent toxic effects of selected chemicals on marine organisms." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/211051.

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Anthropogenically driven climate change not only results in rising of sea temperature but also leads to more frequent and longer-lasting cold and heat waves. Meanwhile, coastal marine ecosystems are constantly challenged by increasing threats of chemical pollution. Temperature and chemical stressors can jointly affect the livelihood of marine organisms, but their combined effects are still poorly understood. Therefore, this study aimed to investigate the effects of thermal stress and chemical exposure on the marine medaka Oryzias melastigma, copepod Tigriopus japonicus and rotifer Brachionus k

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28

Williams, Delyth Einir. "Xenobiotic metabolism in skin and the effect of age." Thesis, Cardiff University, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.395694.

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29

Loveday, J. S. "Skin effect measurements of the bulk modulus of potassium." Thesis, University of Bristol, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233723.

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30

Al-Attwani, Jasim Hussein. "The effect of probiotics on bacterial human skin pathogens." Thesis, University of Plymouth, 2014. http://hdl.handle.net/10026.1/3087.

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Probiotic bacteria have been investigated in the prevention and treatment of various diseases and allergies. The current study was undertaken to determine the effect of eight probiotic Lactobacillus species against bacterial human skin pathogens using several techniques. Antimicrobial activity of lactobacilli against Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa and Propionibacterium acnes was evaluated using lactobacilli broth cultures (BCB) and cell free supernatant (CFS). Antimicrobial activity was significantly greater with BCB compared with CFS especially for L

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31

Prater, Mary Renee. "Immunotoxicity of Dermal Permethrin and Cis-Urocanic Acid: Effects of Chemical Mixtures in Environmental Health." Diss., Virginia Tech, 2002. http://hdl.handle.net/10919/11047.

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The present study examined adverse effects of sunlight exposure (mimicked by intradermal cis-urocanic acid, cUCA) on local and systemic immune responses, with or without co-exposure to the immunotoxic insecticide permethrin. A single exposure to cUCA caused diminished splenic macrophage phagocytosis that was persistent up to 30 days post-exposure. Five-day exposure to cUCA subtly increased splenocyte proliferation in response to the T cell mitogen Concanavalin A. Four-week exposure to cUCA caused increased splenic lymphocyte cellularity, thymic hypocellularity, and enhanced hydrogen peroxide

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32

Rabe, Richard L. "Drag and pressure die flow effects on the production and properties of a Rayon-Nylon skin-core type composite fiber." Ohio University / OhioLINK, 1987. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1183057790.

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33

Quinn, Amie L., and University of Lethbridge Faculty of Arts and Science. "The impacts of agricultural chemicals and temperature on the physiological stress response in fish." Thesis, Lethbridge, Alta. : University of Lethbirdge, Faculty of Arts and Science, 2007, 2007. http://hdl.handle.net/10133/676.

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Fish are exposed to multiple stressors in their environment. The interactive effects of pesticide exposure and increased temperature on the physiological stress response were investigated in a comparative field study with cold-water (whitefish, Prosopium williamsoni) and cool-water (sucker, Catostomus) fish from the Oldman River, Alberta, Canada, and in a laboratory study with rainbow trout, Oncorhynchus mykiss. Physiogical stress indicators were measured, and exposure to pesticides was estimated using acetylcholinesterase (AChE) inhibition. Species-specific differences in AChE activities and

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34

Klíma, Petr. "Skin efekt ve vysokootáčkových elektrických strojích." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2019. http://www.nusl.cz/ntk/nusl-401967.

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This master thesis deals with the suppression of the skin and proximity effects in high-speed machines. The first part summarizes the general knowledge of high-speed machines. The second part is devoted to the principle and possible suppression of consequences caused by skin and proximity effects. The third part shows the simulation results of models of a synchronous machine with permanent magnets. The results of these simulations reveal the consequences of skin and proximity effects. In addition, design measures are proposed to limit these and other undesirable phenomena to achieve the highes

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35

Wang, Qi. "The morphological effect of electron irradiation on the healing of skin wounds and skin grafts in the rat." Thesis, Queen's University Belfast, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324846.

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36

Ray, Chaudhuri Siladitya. "Mathematical Modeling of Percutaneous Absorption of Volatile Solvents Following Transient Liquid-Phase Exposures." University of Cincinnati / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1179468433.

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37

Duit, Rebecca Christina. "Novel insights into hair structure and the effects of chemical stressors on hair and skin using label-free advanced light microscopy." Thesis, Durham University, 2017. http://etheses.dur.ac.uk/12101/.

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There is a need for a better method to image hair as the current methods involve embedding the hair in resin, which may produce artefacts, or using dyes which are limited in their depth of penetration into the hair. The research performed in this thesis endeavours to characterise the cellular structure of human hair with label-free imaging using autofluorescence and fluorescence lifetime imaging. Wavelengths were shown to selectively excite the hair cuticle, cortex and medulla, and subcellular compartments. Development of an optical transverse imaging method enabled discoveries including diffe

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38

Tomic, Tjasa. "Functionalised cellulosic materials for hydrolysis free reactive dyeing and the fixation of effect chemicals." Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.498845.

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39

Young, Stephen Robert. "The effect of therapeutic ultrasound on the biological mechanisms involved in dermal repair." Thesis, King's College London (University of London), 1988. https://kclpure.kcl.ac.uk/portal/en/theses/the-effect-of-therapeutic-ultrasound-on-the-biological-mechanisms-involved-in-dermal-repair(6c2b4920-3344-4112-80f3-04fec1bfefdf).html.

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40

Black, C. E. "The effect of nicotine on endothelial function in human skin flaps." Thesis, Queen's University Belfast, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.403236.

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41

Godart, Marie-Aude. "Effect of skin fracture on failure of a bilayer polymer plate." Thesis, Imperial College London, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.444085.

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42

Grady, George. "The effect of resveratrol on ultraviolet light-induced skin cell death." Marietta College Honors Theses / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=marhonors1366909727.

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43

Suarez, Pozos Edna. "The effect of skin tension on the formation of keloid scars." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/the-effect-of-skin-tension-on-the-formation-of-keloid-scars(6762b081-6818-441b-98e6-6a74ae7b50da).html.

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Keloid scars (KS) are a type of abnormal scarring which is unique to humans. They extend beyond the confines of the original wound margins, do not regress over time and invade the surrounding unaffected skin. The mechanisms involved in the formation of KS remain largely unknown. Clinical observation has shown that in areas where increased tension occurs, such as the sternum, there is a greater propensity for developing KS. However, the precise relationship between skin tension and KS development is yet to be identified. In view of this, I hypothesize that skin tension plays a significant role

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44

Mirrashed, Fakhereh. "High-resolution magnetic resonance imaging of the skin and the effect of hydration." Thesis, University of Exeter, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244405.

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45

Worsham, Jessica Nicole. "5-HT3 Receptor Ligands and Their Effect on Psychomotor Stimulants." VCU Scholars Compass, 2008. http://scholarscompass.vcu.edu/etd/1054.

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Drug abuse and addiction are considered to be a result, at least in part, of the rewarding effects produced by increasing dopamine levels. 5-HT3 serotonin receptors have been shown to indirectly affect dopamine levels. Therefore, the effect of the 5-HT3 receptor partial agonist, MD-354, on the actions of psychomotor stimulants was analyzed in mouse locomotor activity assays to determine whether MD-354 is working through a 5-HT3 receptor agonist or antagonist mode of action. Studies with (+)amphetamine and (+)methamphetamine in combination with MD-354 indicated MD-354 is either devoid of actio

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46

Nongauza, Sinethemba Aubrey. "An investigation of the effect of co-solvents on the hydrothermal liquefaction of microalgae biomass." Thesis, Nelson Mandela Metropolitan University, 2015. http://hdl.handle.net/10948/21667.

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The study introduces and demonstrates the viability of the continuous flow reactor (CFR) system for the production of bio-crude oil (BCO) from wet microalgae. Preliminary experiments conducted in the CFR system in hot compressed water (HCW) were successful in converting wet microalgae into liquid BCO. However, the synthesis and aggregation of high boiling point (HBP) components of BCO and the accumulation of char in the tubular piping of CFR system were identified as the limiting factor to the viability of the system. The aggregation of HBP components and the accumulation of char result to sys

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47

Benetti, Monã Hegel. "Efeito skin no dínamo de Ponomarenko." reponame:Repositório Institucional da UFABC, 2017.

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Orientador: Prof. Dr. Francisco Eugenio Mendonça da Silveira<br>Dissertação (mestrado) - Universidade Federal do ABC, Programa de Pós-Graduação em Física, 2017.<br>Através do estudo da teoria cinética dos dínamos, onde se destaca o dínamo ou processo de Ponomarenko, nos deparamos com uma análise, até agora desenvolvida na literatura, restrita à aproximação em que a superfície que encerra o escoamento responsável pelo efeito dínamo é considerada dielétrica. Este trabalho oferece um tratamento analítico do processo de Ponomarenko onde essa mesma superfície, que confina o movimento do fluido, pas

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48

Van, der Merwe Deon. "The dermal absorption of selected agricultural and industrial chemicals through porcine skin with emphasis on chemical mixture effects." 2005. http://www.lib.ncsu.edu/theses/available/etd-10192005-091808/unrestricted/etd.pdf.

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HABERKAMP, MARGO BETH. "THE EFFECT OF PHYSICAL AND CHEMICAL INJURIES ON TRANSEPIDERMAL WATER LOSS AND TURNOVER TIME OF HAIRLESS MOUSE SKIN (SKIN INJURIES)." 1989. http://catalog.hathitrust.org/api/volumes/oclc/68235146.html.

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Yu, Hong. "The effect of chemical finishing on the microbial transfer from carpets to human skin and selected fabrics." 2007. http://purl.galileo.usg.edu/uga%5Fetd/yu%5Fhong%5F200708%5Fphd.

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