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1

Pera, M. F., B. Reubinoff, and A. Trounson. "Human embryonic stem cells." Journal of Cell Science 113, no. 1 (2000): 5–10. http://dx.doi.org/10.1242/jcs.113.1.5.

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Embryonic stem (ES) cells are cells derived from the early embryo that can be propagated indefinitely in the primitive undifferentiated state while remaining pluripotent; they share these properties with embryonic germ (EG) cells. Candidate ES and EG cell lines from the human blastocyst and embryonic gonad can differentiate into multiple types of somatic cell. The phenotype of the blastocyst-derived cell lines is very similar to that of monkey ES cells and pluripotent human embryonal carcinoma cells, but differs from that of mouse ES cells or the human germ-cell-derived stem cells. Although ou
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2

HOSSEINI, Hamid, and S. MOOSAVI-NEJAD. "1A34 Shock waves effects on embryonic stem cells." Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2014.26 (2014): 35–36. http://dx.doi.org/10.1299/jsmebio.2014.26.35.

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3

Cezar, Gabriela Gebrin. "Embryonic Stem Cells." International Journal of Pharmaceutical Medicine 20, no. 2 (2006): 107–14. http://dx.doi.org/10.2165/00124363-200620020-00004.

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4

Wagner, Erwin F. "Embryonic stem cells." Current Opinion in Oncology 4 (December 1992): S2—S4. http://dx.doi.org/10.1097/00001622-199212001-00002.

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5

Rippon, H. J., and A. E. Bishop. "Embryonic stem cells." Cell Proliferation 37, no. 1 (2004): 23–34. http://dx.doi.org/10.1111/j.1365-2184.2004.00298.x.

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6

Biswas, Atindriya, and Robert Hutchins. "Embryonic Stem Cells." Stem Cells and Development 16, no. 2 (2007): 213–22. http://dx.doi.org/10.1089/scd.2006.0081.

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7

Etches, Robert J. "Embryonic stem cells." Lancet Oncology 2, no. 3 (2001): 131–32. http://dx.doi.org/10.1016/s1470-2045(00)00252-7.

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8

Hampton, Tracy. "Embryonic Stem Cells." JAMA 297, no. 5 (2007): 459. http://dx.doi.org/10.1001/jama.297.5.459-a.

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9

Morowitz, Harold. "Embryonic stem cells." Complexity 8, no. 3 (2003): 10–11. http://dx.doi.org/10.1002/cplx.10080.

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10

Bishop, Anne E., Lee D. K. Buttery, and Julia M. Polak. "Embryonic stem cells." Journal of Pathology 197, no. 4 (2002): 424–29. http://dx.doi.org/10.1002/path.1154.

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11

Challa, Stalin Reddy, and Swathi Goli. "Differentiation of Human Embryonic Stem Cells into Engrafting Myogenic Precursor Cells." Stem cell Research and Therapeutics International 1, no. 1 (2019): 01–05. http://dx.doi.org/10.31579/2643-1912/002.

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Degenerative muscle diseases affect muscle tissue integrity and function. Human embryonic stem cells (hESC) are an attractive source of cells to use in regenerative therapies due to their unlimited capacity to divide and ability to specialize into a wide variety of cell types. A practical way to derive therapeutic myogenic stem cells from hESC is lacking. In this study, we demonstrate the development of two serum-free conditions to direct the differentiation of hESC towards a myogenic precursor state. Using TGFß and PI3Kinase inhibitors in combination with bFGF we showed that one week of diffe
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12

Liu, De Wu, Yong Tie Li, De Ming Liu, and Pu Ning. "Culture and Characteristics of Human Induced Pluripotent Stem Cells." Advanced Materials Research 268-270 (July 2011): 835–37. http://dx.doi.org/10.4028/www.scientific.net/amr.268-270.835.

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Human induced pluripotent stem cells is promising for regenerative medicine and tissue engineering. In this chapter, we focus on the culture and characteristics of human induced pluripotent stem cells. The induced pluripotent stem cells were plated on murine embryonic fibroblast feeder cells and expanded in human embryonic stem cells media contained basic fibroblast growth factor. The cells were passaged by collagenase IV digestion method and observed under invert microscope. The expression of alkaline phosphatase was detected by immunocytochemistry. The cultured induced pluripotent stem cells
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13

Azab, Azab. "Stem Cells: Insights into Niche, Classification, Identification, Characterization, Mechanisms of Regeneration by Using Stem Cells, and Applications in Joint Disease Remedy." Biotechnology and Bioprocessing 2, no. 1 (2021): 01–07. http://dx.doi.org/10.31579/2766-2314/024.

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Background: Stem cell therapy has attracted much interest in the 21st century, not only because of the controversy surrounding the ethics involving pluripotent stem cells, but their potential for clinical use. Objectives: The present review highlights the stem cells niche, types, identification, and characterization, mechanisms of regeneration by using stem cells, and applications in joint disease remedy. Stem cells could be well differentiated cells with the potential to display different cell types depending on the host niche. Niche is defined as the cellular microenvironment providing suppo
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14

Bhartiya, Deepa, Sandhya Anand, and Hiren Patel. "Making gametes from pluripotent stem cells: embryonic stem cells or very small embryonic-like stem cells?" Stem Cell Investigation 3 (October 14, 2016): 57. http://dx.doi.org/10.21037/sci.2016.09.06.

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15

Dani, C., A. G. Smith, S. Dessolin, et al. "Differentiation of embryonic stem cells into adipocytes in vitro." Journal of Cell Science 110, no. 11 (1997): 1279–85. http://dx.doi.org/10.1242/jcs.110.11.1279.

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Embryonic stem cells, derived from the inner cell mass of murine blastocysts, can be maintained in a totipotent state in vitro. In appropriate conditions embryonic stem cells have been shown to differentiate in vitro into various derivatives of all three primary germ layers. We describe in this paper conditions to induce differentiation of embryonic stem cells reliably and at high efficiency into adipocytes. A prerequisite is to treat early developing embryonic stem cell-derived embryoid bodies with retinoic acid for a precise period of time. Retinoic acid could not be substituted by adipogeni
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16

Pacholczyk, Tadeusz. "Rethinking Embryonic Stem Cells." Ethics & Medics 33, no. 4 (2008): 1–3. http://dx.doi.org/10.5840/em20083347.

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17

Wilmut, I. "Human Embryonic Stem Cells." Science 310, no. 5756 (2005): 1903c. http://dx.doi.org/10.1126/science.1123832.

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18

Daley, George Q. "Histocompatible embryonic stem cells." Cell Research 18, S1 (2008): S2. http://dx.doi.org/10.1038/cr.2008.92.

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19

Clements, M. "Human Embryonic Stem Cells." British Journal of Cancer 90, no. 2 (2004): 558–59. http://dx.doi.org/10.1038/sj.bjc.6601577.

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20

HENRY, CELIA. "EMBRYONIC STEM CELLS' SUPPORT." Chemical & Engineering News 81, no. 42 (2003): 9. http://dx.doi.org/10.1021/cen-v081n042.p009a.

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21

Wray, Jason, and Christine Hartmann. "WNTing embryonic stem cells." Trends in Cell Biology 22, no. 3 (2012): 159–68. http://dx.doi.org/10.1016/j.tcb.2011.11.004.

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22

Choong, Cleo, and Mahendra S. Rao. "Human Embryonic Stem Cells." Neurosurgery Clinics of North America 18, no. 1 (2007): 1–14. http://dx.doi.org/10.1016/j.nec.2006.10.004.

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23

Trounson, Alan, and Martin Pera. "Human embryonic stem cells." Fertility and Sterility 76, no. 4 (2001): 660–61. http://dx.doi.org/10.1016/s0015-0282(01)02880-1.

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24

Letso, Reka R., and Brent R. Stockwell. "Renewing embryonic stem cells." Nature 444, no. 7120 (2006): 692–93. http://dx.doi.org/10.1038/444692b.

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25

Nichols, Jennifer. "Introducing embryonic stem cells." Current Biology 11, no. 13 (2001): R503—R505. http://dx.doi.org/10.1016/s0960-9822(01)00304-9.

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26

West, J. A., and G. Q. Daley. "Human embryonic stem cells." Bone Marrow Transplantation 33, no. 1 (2004): 135. http://dx.doi.org/10.1038/sj.bmt.1704315.

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27

Gama, Vivian, and Mohanish Deshmukh. "Human embryonic stem cells." Cell Cycle 11, no. 21 (2012): 3905–6. http://dx.doi.org/10.4161/cc.22233.

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28

Damdimopoulou, Pauliina, Sergey Rodin, Sonya Stenfelt, Liselotte Antonsson, Karl Tryggvason, and Outi Hovatta. "Human embryonic stem cells." Best Practice & Research Clinical Obstetrics & Gynaecology 31 (February 2016): 2–12. http://dx.doi.org/10.1016/j.bpobgyn.2015.08.010.

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29

Koestenbauer, Sonja, Nicolas H. Zech, Herbert Juch, Pierre Vanderzwalmen, Luc Schoonjans, and Gottfried Dohr. "Embryonic Stem Cells: Similarities and Differences Between Human and Murine Embryonic Stem Cells." American Journal of Reproductive Immunology 55, no. 3 (2006): 169–80. http://dx.doi.org/10.1111/j.1600-0897.2005.00354.x.

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30

Nagy, Andras, Marina Gertsenstein, Kristina Vintersten, and Richard Behringer. "Differentiating Embryonic Stem (ES) Cells into Embryoid Bodies." Cold Spring Harbor Protocols 2006, no. 2 (2006): pdb.prot4405. http://dx.doi.org/10.1101/pdb.prot4405.

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31

Zhang, Yue Shelby, Ana Sevilla, Leo Q. Wan, Ihor R. Lemischka, and Gordana Vunjak-Novakovic. "Patterning pluripotency in embryonic stem cells." STEM CELLS 31, no. 9 (2013): 1806–15. http://dx.doi.org/10.1002/stem.1468.

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32

Guo, Jitong, Baojiang Wu, Shuyu Li, et al. "Contribution of Mouse Embryonic Stem Cells and Induced Pluripotent Stem Cells to Chimeras through Injection and Coculture of Embryos." Stem Cells International 2014 (2014): 1–9. http://dx.doi.org/10.1155/2014/409021.

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Blastocyst injection and morula aggregation are commonly used to evaluate stem cell pluripotency based on chimeric contribution of the stem cells. To assess the protocols for generating chimeras from stem cells, 8-cell mouse embryos were either injected or cocultured with mouse embryonic stem cells and induced pluripotent stem cells, respectively. Although a significantly higher chimera rate resulted from blastocyst injection, the highest germline contribution resulted from injection of 8-cell embryos with embryonic stem cells. The fully agouti colored chimeras were generated from both injecti
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33

Perlingeiro, Rita C. R., Michael Kyba, and George Q. Daley. "Clonal analysis of differentiating embryonic stem cells reveals a hematopoietic progenitor with primitive erythroid and adult lymphoid-myeloid potential." Development 128, no. 22 (2001): 4597–604. http://dx.doi.org/10.1242/dev.128.22.4597.

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Embryonic stem (ES) cells differentiate into multiple hematopoietic lineages during embryoid body formation in vitro, but to date, an ES-derived hematopoietic stem cell has not been identified and subjected to clonal analysis in a manner comparable with hematopoietic stem cells from adult bone marrow. As the chronic myeloid leukemia-associated BCR/ABL oncogene endows the adult hematopoietic stem cell with clonal dominance without inhibiting pluripotent lymphoid and myeloid differentiation, we have used BCR/ABL as a tool to enable engraftment and clonal analysis. We show that embryoid body-deri
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34

Sharpe, N. G., D. G. Williams, and D. S. Latchman. "Regulated expression of the small nuclear ribonucleoprotein particle protein SmN in embryonic stem cell differentiation." Molecular and Cellular Biology 10, no. 12 (1990): 6817–20. http://dx.doi.org/10.1128/mcb.10.12.6817-6820.1990.

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The SmN protein is a component of small nuclear ribonucleoprotein particles and is closely related to the ubiquitous SmB and B' splicing proteins. It is expressed in a limited range of tissues and cell types, including several undifferentiated embryonal carcinoma cell lines and undifferentiated embryonic stem cells. The protein declines to undetectable levels when embryonal carcinoma or embryonic stem cells are induced to differentiate, producing primitive endoderm or parietal endoderm or yielding embryonal bodies. This decline is due to a corresponding decrease in the level of the SmN mRNA. T
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35

Sharpe, N. G., D. G. Williams, and D. S. Latchman. "Regulated expression of the small nuclear ribonucleoprotein particle protein SmN in embryonic stem cell differentiation." Molecular and Cellular Biology 10, no. 12 (1990): 6817–20. http://dx.doi.org/10.1128/mcb.10.12.6817.

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The SmN protein is a component of small nuclear ribonucleoprotein particles and is closely related to the ubiquitous SmB and B' splicing proteins. It is expressed in a limited range of tissues and cell types, including several undifferentiated embryonal carcinoma cell lines and undifferentiated embryonic stem cells. The protein declines to undetectable levels when embryonal carcinoma or embryonic stem cells are induced to differentiate, producing primitive endoderm or parietal endoderm or yielding embryonal bodies. This decline is due to a corresponding decrease in the level of the SmN mRNA. T
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36

Wang, Yuan, Frank Yates, Eugenia Dikovskaia, et al. "Derivation of Hematopoietic Stem Cells from Embryonic Stem Cells." Blood 104, no. 11 (2004): 223. http://dx.doi.org/10.1182/blood.v104.11.223.223.

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Abstract Despite the significant in vitro blood-forming potential of murine embryonic stem cells (ESCs), deriving hematopoietic stem cells (HSCs) that can reconstitute irradiated mice has proven to be challenging. Previously, we successfully engrafted lethally irradiated adult mice with ESCs engineered to ectopically express the homeodomain gene hoxB4. In engrafted animals, blood reconstitution showed a myeloid predominance, likely due to an inability to fully pattern the adult HSC from these embryonic populations. Recently, we have investigated cdx4, a caudal-related homeobox gene whose funct
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37

Larrú, M. "Adult stem cells: an alternative to embryonic stem cells?" Trends in Biotechnology 19, no. 12 (2001): 487. http://dx.doi.org/10.1016/s0167-7799(01)01867-4.

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38

LENGERKE, C., and G. DALEY. "Patterning definitive hematopoietic stem cells from embryonic stem cells." Experimental Hematology 33, no. 9 (2005): 971–79. http://dx.doi.org/10.1016/j.exphem.2005.06.004.

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39

Andrews, Peter W. "From teratocarcinomas to embryonic stem cells." Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 357, no. 1420 (2002): 405–17. http://dx.doi.org/10.1098/rstb.2002.1058.

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The recent derivation of human embryonic stem (ES) cell lines, together with results suggesting an unexpected degree of plasticity in later, seemingly more restricted, stem cells (so–called adult stem cells), have combined to focus attention on new opportunities for regenerative medicine, as well as for understanding basic aspects of embryonic development and diseases such as cancer. Many of the ideas that are now discussed have a long history and much has been underpinned by the earlier studies of teratocarcinomas, and their embryonal carcinoma (EC) stem cells, which present a malignant surro
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40

Zerhouni, E. "EMBRYONIC STEM CELLS: Enhanced: Stem Cell Programs." Science 300, no. 5621 (2003): 911–12. http://dx.doi.org/10.1126/science.1084819.

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41

Wang, Y., F. Yates, O. Naveiras, P. Ernst, and G. Q. Daley. "Embryonic stem cell-derived hematopoietic stem cells." Proceedings of the National Academy of Sciences 102, no. 52 (2005): 19081–86. http://dx.doi.org/10.1073/pnas.0506127102.

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42

Sharma, Dinesh Kumar. "Comparative Study of Human Embryonic and Adult Stem Cells: A Review." Indian Journal of Genetics and Molecular Research 8, no. 1 (2019): 27–34. http://dx.doi.org/10.21088/ijgmr.2319.4782.8119.4.

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43

Chen, Yifei, and Dongmei Lai. "Pluripotent States of Human Embryonic Stem Cells." Cellular Reprogramming 17, no. 1 (2015): 1–6. http://dx.doi.org/10.1089/cell.2014.0061.

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44

Koch, Cody A., Pedro Geraldes, and Jeffrey L. Platt. "Immunosuppression by Embryonic Stem Cells." Stem Cells 26, no. 1 (2008): 89–98. http://dx.doi.org/10.1634/stemcells.2007-0151.

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45

Calabrese, Edward J. "Hormesis and embryonic stem cells." Chemico-Biological Interactions 352 (January 2022): 109783. http://dx.doi.org/10.1016/j.cbi.2021.109783.

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46

Tonti-Filippini, Nicholas, and Peter McCullagh. "Embryonic Stem Cells and Totipotency." Ethics & Medics 25, no. 7 (2000): 1–3. http://dx.doi.org/10.5840/em200025713.

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47

Travis, J. "Human Embryonic Stem Cells Found?" Science News 152, no. 3 (1997): 36. http://dx.doi.org/10.2307/3980870.

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48

Daley, George Q. "Customized human embryonic stem cells." Nature Biotechnology 23, no. 7 (2005): 826–28. http://dx.doi.org/10.1038/nbt0705-826.

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49

Borge, Ole. "Embryonic and Adult Stem Cells." Acta Veterinaria Scandinavica 45, Suppl 1 (2004): S39. http://dx.doi.org/10.1186/1751-0147-45-s1-s39.

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50

Redi, Carlo Alberto. "Human embryonic stem cells handbook." European Journal of Histochemistry 57, no. 1 (2013): 2. http://dx.doi.org/10.4081/ejh.2013.br2.

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