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Bücher zum Thema „Enzyme activation“

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1

H, Stenmark, ed. Phosphoinositides in subcellular targeting and enzyme activation. Springer, 2004.

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2

Stenmark, Harald, ed. Phosphoinositides in Subcellular Targeting and Enzyme Activation. Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/978-3-642-18805-3.

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3

Alan, Wiseman, ed. Enzyme induction, mutagen activation, and carcinogen testing in yeast. E. Horwood, 1987.

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4

Mordechai, Liscovitch, ed. Signal-activated phospholipases. R.G. Landes Co., 1994.

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5

H, Schmid-Schönbein, Wurzinger L. J, Zimmermann R. E, and Commission of the European Communities. Committee on Medical and Public Health Research., eds. Enzyme activation in blood-perfused artificial organs: Proceedings of an interdisciplinary meeting. Nijhoff, 1985.

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6

Light, P. E. An investigation into factors controlling activation of the enzyme protein Kinase C in the regulation of neurotransmitter release at the frog neuromuscular junction. University of Birmingham, 1990.

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7

Chen, Chang-Hwei. Activation and Detoxification Enzymes. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-1049-2.

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8

Chen, Chang-Hwei. Activation and Detoxification Enzymes. Springer Nature Switzerland, 2024. http://dx.doi.org/10.1007/978-3-031-55287-8.

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9

Zdeněk, Deyl, ed. HPLC in enzymatic analysis. 2nd ed. Wiley, 1998.

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10

1923-, Lorand Laszlo, and Mann Kenneth G, eds. Proteolytic enzymes in coagulation, fibrinolysis, and complement activation. Academic Press, 1993.

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11

M, Cunningham Fiona, ed. Lipid mediators. Academic Press, 1994.

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12

C, Murphy Robert, and Fitzpatrick Frank A, eds. Arachidonate related lipid mediators. Academic Press, 1990.

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13

Stein, Ross L. Kinetics of Enzyme Action. Wiley & Sons, Incorporated, John, 2011.

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14

Stenmark, Harald. Phosphoinositides in Subcellular Targeting and Enzyme Activation. Springer London, Limited, 2012.

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15

Stein, Ross L. Kinetics of Enzyme Action: Essential Principles for Drug Hunters. Wiley & Sons, Incorporated, John, 2011.

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16

Stein, Ross L. Kinetics of Enzyme Action: Essential Principles for Drug Hunters. Wiley & Sons, Incorporated, John, 2011.

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17

Stein, Ross L. Kinetics of Enzyme Action: Essential Principles for Drug Hunters. Wiley & Sons, Incorporated, John, 2011.

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18

Enzymes in metabolic pathways: A comparative study of mechanism, structure, evolution, and control. Harper & Row, 1987.

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19

Stenmark, Harald. Phosphoinositides in Subcellular Targeting and Enzyme Activation. Springer, 2003.

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20

Stenmark, Harald. Phosphoinositides in Subcellular Targeting and Enzyme Activation. Springer, 2012.

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21

Phosphoinositides in Subcellular Targeting and Enzyme Activation. Island Press, 2003.

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22

Enzymology LabFax (Labfax Series). Academic Press, 1996.

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23

Metod KʹmVʹ-sistemy koordinat v fermentativnoĭ kinetike. Akademii͡a nauk SSSR, Nauch. t͡sentr biologicheskikh issledovaniĭ, In-t biokhimii i fiziologii mikroorganizmov, 1987.

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24

Cooper, A. The Enzyme Catalysis Process:Energetics, Mechanism and Dynamics. Springer, 1989.

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25

Baici, Antonio. Kinetics of Enzyme-Modifier Interactions: Selected Topics in the Theory and Diagnosis of Inhibition and Activation Mechanisms. Baici Antonio, 2015.

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26

Baici, Antonio. Kinetics of Enzyme-Modifier Interactions: Selected Topics in the Theory and Diagnosis of Inhibition and Activation Mechanisms. Springer, 2016.

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27

Baici, Antonio. Kinetics of Enzyme-Modifier Interactions: Selected Topics in the Theory and Diagnosis of Inhibition and Activation Mechanisms. Springer London, Limited, 2015.

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28

Activation And Detoxification Enzymes Functions And Implications. Springer, 2011.

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29

Soda, Kenji, and Toshio Fukui. Molecular Aspects of Enzyme Catalysis. Wiley & Sons, Incorporated, John, 2008.

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30

Soda, Kenji, and Toshio Fukui. Molecular Aspects of Enzyme Catalysis. Wiley & Sons, Limited, John, 2007.

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31

Molecular aspects of enzyme catalysis. Kodansha, 1994.

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32

Cascorbi, Ingolf. Polymorphic cytochrome P450 2D6 as the responsible enzyme of activation. Edited by Paul Farquhar-Smith, Pierre Beaulieu, and Sian Jagger. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198834359.003.0079.

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The landmark paper discussed in this chapter is ‘Bioactivation of the narcotic drug codeine in human liver is mediated by the polymorphic monooxygenase catalyzing debrisoquine 4-hydroxylation (cytochrome P-450 dbl/bufI)’, published by Dayer et al. in 1988. Codeine is an old but frequently prescribed drug used for the treatment of mild-to-moderate pain. However, its use is nowadays restricted after observations of partly fatal respiratory repression in children. Codeine itself exhibits no analgesic effect, but is partly activated by O-demethylation to morphine by cytochrome P450 2D6 (CYP2D6). T
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33

Lyle, Stephen. The sulfate-activation pathway: A bifunctional enzyme which utilizes intermediate channeling. 1993.

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34

Clarke, Andrew. Temperature and reaction rate. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780199551668.003.0007.

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All other things being equal, physiological reaction rate increases roughly exponentially with temperature. Organisms that have adapted over evolutionary time to live at different temperatures can have enzyme variants that exhibit similar kinetics at the temperatures to which they have adapted to operate. Within species whose distribution covers a range of temperatures, there may be differential expression of enzyme variants with different kinetics across the distribution. Enzymes adapted to different optimum temperatures differ in their amino acid sequence and thermal stability. The Gibbs ene
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35

Brown, Stephanie Leanne. The biosynthesis of poly (ribitol-phosphate) wall teichoic acids and the roles of individual tailoring modifications. 2011.

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36

Yuan, Yanqiu. Targeting the bacterial cell wall: Structural insight into peptidoglycan glycosyltransferases and moenomycin inhibition. 2008.

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37

Smerage, Jeffrey. Activated Transcription of the Glycolytic Enzyme Genes of Saccharomyces Cerevisiae: The Chromatin Structures of TP11 and Mechanisms of RAP1P Mediated Activation. Dissertation Discovery Company, 2018.

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38

Smerage, Jeffrey. Activated Transcription of the Glycolytic Enzyme Genes of Saccharomyces Cerevisiae: The Chromatin Structures of TP11 and Mechanisms of RAP1P Mediated Activation. Creative Media Partners, LLC, 2018.

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39

Deegan, Patrick. Porphyria. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0179.

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This chapter discusses six diseases caused by inborn errors of metabolism affecting the biosynthesis of haem. Haem is a tetracyclic metal-binding compound involved in oxygen transport (in haemoglobin and myoglobin) and redox reactions (e.g. in the cytochrome P450 system). Each of these conditions is caused by a single gene defect in one of the enzymes involved in the biosynthesis of haem. Inheritance is usually autosomal dominant with incomplete penetrance. The enzyme defect results in disease, not as a result of deficiency of the reaction product, but as a result of accumulation of precursors
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40

O’Neal, M. Angela. Pain in the Back. Edited by Angela O’Neal. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190609917.003.0006.

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This case explores how bone health can be affected by antiepileptic drugs (AEDs), and why this is an important issue in women with epilepsy (WWE). AEDs affect bone health through activation of the cytochrome P450 system in the liver, leading to increased metabolism of vitamin D. The enzyme-inducing AEDs include phenytoin, carbamazepine, phenobarbital, and primidone. Risk factors for osteoporosis include female gender, low body mass, inadequate vitamin D intake, and smoking. The specific AEDs used and the length of treatment confer additional risks. Furthermore, in WWE, risks are magnified rela
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41

HPLC in Enzymatic Analysis. Wiley & Sons, Incorporated, John, 2006.

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42

Rossomando, Edward F. HPLC in Enzymatic Analysis. Wiley & Sons, Incorporated, John, 2009.

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43

Chen, Chang-Hwei. Activation and Detoxification Enzymes: Functions and Implications. Springer, 2014.

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44

Chen, Chang-Hwei. Activation and Detoxification Enzymes: Functions and Implications. Springer, 2011.

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45

Activation and Detoxification Enzymes: Functions and Implications. Springer, 2024.

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46

Hester, Charles K. Mitogen-Activated Protein Kinases: Activation, Functions and Regulation. Nova Science Publishers, Incorporated, 2019.

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47

Frenkel, Joost, and Hans R. Waterham. Mevalonate Kinase Deficiency. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199972135.003.0039.

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Mevalonate kinase deficiency (MKD) is an autosomal recessive inborn error of isoprenoid biosynthesis, a pathway yielding sterols and nonsterol isoprenoids.In patients, the enzyme activity of mevalonate kinase is severely reduced due to mutations in the encoding gene, MVK. The substrate, mevalonate, accumulates and is elevated in blood and urine. Shortage of certain downstream products of the pathway, nonsterol isoprenoids, leads to dysregulation of the innate immune system, activation of inflammasomes, and interleukin (IL)-1 mediated inflammation.Symptoms start in early childhood with recurren
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48

Rider, Lisa G., and Frederick W. Miller. Outcome assessment in the idiopathic inflammatory myopathies. Edited by Hector Chinoy and Robert Cooper. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198754121.003.0016.

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Due to their rarity, heterogeneity, and multispecialty nature, the myositis syndromes have limited data-driven consensus on appropriate outcome measures. Recently, two international, multispecialty consortia developed new tools and consensus on core set measures of myositis disease activity and damage, as well as response criteria that are now recommended for use as clinical trial endpoints but will also be useful in clinical practice. Magnetic resonance imaging, muscle ultrasound, selected laboratory tests, and immunological biomarkers—including cytokines, chemokines, lymphocyte flow cytometr
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49

(Editor), John N. Abelson, Melvin I. Simon (Editor), Laszlo Lorand (Editor), and Kenneth G. Mann (Editor), eds. Proteolytic Enzymes in Coagulation, Fibrinolysis, and Complement Activation, Part B, Volume 223: Volume 223: Proteolytic Enzymes in Coagulation, Fibrinolysis ... Activation Part B (Methods in Enzymology). Academic Press, 1993.

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50

Abelson, John N., Laszlo Lorand, Melvin I. Simon, and Kenneth G. Mann. Proteolytic Enzymes in Coagulation, Fibrinolysis, and Complement Activation, Part B. Elsevier Science & Technology Books, 1993.

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