Thematische Bibliographien / Epigenetic reprograming / Dissertationen
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Dissertationen zum Thema „Epigenetic reprograming“

Autor: Grafiati
Veröffentlicht am 25. Mai 2024

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1

Bagci, Hakan. "Epigenetic reprogramming and DNA demethylation." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/45352.

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Embryonic development begins with fertilization of the egg, a progressive process that gives rise to the zygote and subsequently to the formation of somatic tissues. Normally once cells acquire a fate, it is stably maintained. Conversion back to a multipotent state occurs rarely in-vivo, but can be achieved experimentally by inducing ‘reprogramming’. In this study I am looking at the epigenetic mechanisms that underlie reprogramming and, in particular, DNA methylation and demethylation. To address this I am taking advantage of the cellular fusion system. Fusion of pluripotent cells with differ
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2

Hajkova, Petra. "Epigenetic reprogramming in mouse germ cells." [S.l. : s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=970526938.

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3

Rao, Venkata Lakshmi Prakruthi. "Epigenetic Reprogramming at the Th2 Locus." University of Cincinnati / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1543838686940608.

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4

Ribeiro, Lemos Pereira Carlos Filipe. "Epigenetic events underlying somatic cell reprogramming." Thesis, Imperial College London, 2008. http://hdl.handle.net/10044/1/4439.

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Although differentiated cells normally retain cell-type-specific gene expressionpatterns throughout their lifetime, cell identity can sometimes be modified or reversedin vivo by transdifferentiation, or experimentally through cell fusion or by nucleartransfer. Several studies have illustrated the importance of chromatin remodelling, DNAdemethylation and dominant transcriptional factor expression for changes in lineageidentity. Here the epigenetic mechanisms required to ?reset? genome function wereinvestigated using experimental heterokaryons.To examine the epigenetic changes that are required
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5

Hajkova, Petra. "Epigenetic reprogramming in mouse germ cells." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2004. http://dx.doi.org/10.18452/15020.

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Bei Säugerkeimzellen, Zygoten und Embryos in frühen Stadien kommt der epigenetischen Neuprogammierung eine außergewöhnlich wichtige Rolle in der Regulation der Genomfunktionen in entscheidenden Entwicklungsstadien zu. Die epigenetische Neuprogrammierung in Keimzellen löscht zuerst die Imprinting-Markierungen und Epi-Mutationen und stellt dann geschlechtsspezifische Markierungen (genomische Prägung) wieder her. Die vorliegende Arbeit bezieht sich auf das Löschen epigenetischer Modifikationen in primordialen Mauskeimzellen (primordial germ cells (PGCs)) zwischen dem 10.5 bis 13.5 Tag nach der
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Dura, Mathilde. "Critical and different roles of DNA methylation in male germ cell development." Electronic Thesis or Diss., Sorbonne université, 2021. http://www.theses.fr/2021SORUS187.

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La méthylation de l'ADN, associée à la répression des gènes et des éléments transposables (ET), joue un rôle essentiel dans la spermatogenèse. Le méthylome des futurs gamètes est reprogrammé : les profils de méthylation somatiques sont effacés, des profils spécifiques des cellules germinales sont établis. Trois de novo ADN méthyltransférases (DNMT) sont essentielles à la méthylation de l'ADN des cellules germinales mâles chez la souris : les enzymes DNMT3C et DNMT3A et leur cofacteur DNMT3L. Il a été montré que DNMT3C est l'enzyme qui méthyle sélectivement les ET les plus jeunes évolutivement.
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Oksuz, Samet. "Targeting IL-4 locus for epigenetic reprogramming." University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1423581203.

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8

Yong, Qian Yu. "A screen for modifiers of epigenetic reprogramming." Thesis, Queensland University of Technology, 2011. https://eprints.qut.edu.au/50955/1/Qian_Yu_Yong_Thesis.pdf.

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Epigenetic modifiers are the proteins involved in establishing and maintaining the epigenome of an organism. They are particularly important for development. Changes in epigenetic modifiers have been shown be lethal, or cause diseases. Our laboratory has developed an ENU mutagenesis screen to produce mouse mutants displaying altered epigenetic gene silencing. The screen relies on a GFP transgene that is expressed in red blood cells in a variegated manner. In the orginal transgenic FVB mice expression occurs in approximately 55% of red blood cells. During the course of my Masters, I ch
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Aguilar, Sanchez Cristina. "Epigenetic transitions in cardiovascular development and cell reprogramming." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28787.

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Epigenetic modifications are alterations in the cell nucleus that affect gene expression and can occur in chromatin at the level of DNA methylation or histone modifications. Such ‘epigenetic marks’ can be heritable through cell division but leave the DNA sequence unchanged. Post-­translational modifications can be found on the histone proteins associated with DNA; the majority of histone modifications are found on the lysine-­rich N-‐terminal amino acid “tails”. Histone acetylation and methylation influence the chromatin structure by loosening or tightening the packaging of DNA, respectively,
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Wanichnopparat, Wachiraporn [Verfasser]. "Epigenetic reprogramming of hepatocyte-like cells / Wachiraporn Wanichnopparat." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2020. http://d-nb.info/1239645333/34.

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11

Eggan, Kevin C. (Kevin Carl) 1974. "Cloning, stem cells and epigenetic reprogramming after nuclear transfer." Thesis, Massachusetts Institute of Technology, 2003. http://hdl.handle.net/1721.1/29931.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2003.<br>Includes bibliographical references (leaves 128-146).<br>The process by which a single totipotent cell becomes a complex organism is a unidirectional program, with each mitotic division generating new cells that gradually differentiate towards more specified fates and specialized functions. Nuclear transfer (NT) experiments have demonstrated the epigenetic nature of development and showed, that although differentiated cells have a very limited developmental potential, the nuclei of these cells retain the potency
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Moley, Laura A. "Epigenetic Reprogramming, Apoptosis, and Developmental Competence in Cloned Embryos." DigitalCommons@USU, 2019. https://digitalcommons.usu.edu/etd/7571.

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Cloning through somatic cell nuclear transfer (SCNT) remains highly inefficient twenty years after the first demonstration of the technology with the birth of Dolly. By increasing efficiency by selecting the embryos early in development that are most likely to succeed following transfer into a surrogate mother, the technology could be more routinely utilized to enhance animal agriculture production. SCNT is believed to be highly inefficient as a result of incorrect DNA methylation and gene expression that are accumulated because of the SCNT technique. We proposed the use of a non-toxic, non-in
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Mariano, Piero. "Epigenetic Regulation and Reprogramming of the H19 Imprinting Control Region." Doctoral thesis, Uppsala universitet, Zoologisk utvecklingsbiologi, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6299.

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The development of a new individual from the fertilized oocyte can ultimately be seen as the consequence of the establishment and maintenance of specific patterns of gene expression. Although regulation of gene activity occurs at different levels, cellular specialization and differentiation are the results of developmental cues that essentially take place at the transcriptional level. The involvement of epigenetics in this process has become increasingly clear during the last decade. Imprinted genes constitute an excellent example as monoallelic expression seems to reflect differential epigene
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Molaro, Antoine. "Inheritance and evolution of epigenetic reprogramming in Mammalian germ cells." Phd thesis, Université Pierre et Marie Curie - Paris VI, 2012. http://tel.archives-ouvertes.fr/tel-00833274.

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During mammalian post-implantation development, germ cells are induced from the somatic tissues of the embryo. Following their induction, primordial germ cells undergo a genome-wide erasure and de novo re-establishment of DNA methylation marks. This epigenetic reprogramming re-instates pluripotency and allows parental imprints to be deposited. In the male germ line, a unique RNAi pathway involving PIWI proteins and their associated small RNAs (piRNAs) is necessary for proper de novo methylation. PIWI mutant mice are infertile and display methylation defects over transposon sequences. Using a t
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Choi, Inchul. "Effects of oocyte on epigenetic reprogramming of bovine SCNT embryos." Thesis, University of Nottingham, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.479364.

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Nguyen, Khoi Thien. "Epigenetic determinants of cellular differentiation, transcriptional reprogramming, and human disease." Thesis, Massachusetts Institute of Technology, 2020. https://hdl.handle.net/1721.1/130186.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, May, 2020<br>Cataloged from student-submitted PDF version of thesis.<br>Includes bibliographical references (pages 111-130).<br>Much of the diversity we observe in cellular and organismal phenotypes can be attributed to epigenetic and genetic variation. DNA provides the instructions for life, while epigenetic modifications regulate which parts of the genetic information contained in DNA can be read out in a given cell and how this information is interpreted. In recent years, epigenetic and genetic vari
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Adams, Kevin Douglas. "Innate Immune Cell Phenotypes Are Dictated by Distinct Epigenetic Reprogramming." BYU ScholarsArchive, 2018. https://scholarsarchive.byu.edu/etd/7700.

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The innate immune system is the first line of host defense against external exposures. During these initial encounters, antigen presenting cells - specifically monocytes and macrophages - modulate further inflammatory responses. Macrophages exist along a spectrum of phenotypic programs; on the inflammatory M1 end they enhance immune activity while on the anti-inflammatory M2 end they suppress further immune activation. Furthermore, within M2 macrophages there exist many subpopulations, namely M2a and M2d, each with specific roles during infection or exposure. We sought to compare the epigeneti
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Pérez, Camps Mireia. "Epigenetic reprogramming of somatic cells by nuclear transplant in zebrafish." Doctoral thesis, Universitat Politècnica de València, 2010. http://hdl.handle.net/10251/6902.

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El estudio de los mecanismos de reprogramación nuclear tiene actualmente una notable importancia, dado que el dominio de estos procesos constituyen la clave para actuar eficazmente en cuestiones tan dispares como el cáncer o la medicina regenerativa. También resulta muy importante este tipo de estudios sobre reprogramación cuando se pretende la obtención de animales transgénicos múltiples y orientados. Aunque para ello se pueden utilizar muy diversos modelos animales, en nuestro caso, se ha optado por el pez cebra, por sus características en el desarrollo, como la brevedad en la embriogénesis
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Wongtawan, Tuempong. "Epigenetic and chromatin reprogramming in mouse development and embryonic stem cells." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/8048.

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It is well established that epigenetics and chromatin modifications are important factors that can govern gene activity and nuclear architecture. They are also proven to be essential for normal embryonic development and cell differentiation. One important event during mouse development is the establishment of epigenetic reprogramming which is believed to be essential for normal growth and development, however; the mechanism is still poorly understood. The general objective of this PhD study was to investigate the profiles and mechanisms of epigenetic and chromatin modifications during normal m
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Gillich, Astrid. "Epigenetic reprogramming of epiblast stem cells to a naïve pluripotent state." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610321.

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21

Wang, Stan. "Reprogramming and epigenetic factors regulating pluripotency and the stem cell state." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709334.

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22

Zhang, Haixin. "Gene regulatory network and epigenetic reprogramming of pig primordial germ cells." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/33452/.

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Primordial germ cells (PGC) are the precursors of the gametes. The mechanisms of PGC induction, specification and development are very well characterized in rodents, however recent investigations have demonstrated that the mechanisms of germ cell development differ significantly between mice and humans. Since the knowledge of PGC development in non-rodents is very limited, and early human embryos cannot be accessed it is important to establish a new model for PGC development with relevance to humans. In this thesis, I use pig embryo as a model for investigating PGC development in non-rodent ma
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Gibson, Adrienne Rae. "Pharmacological ascorbate enhances oxygen consumption and epigenetic reprogramming in pancreatic cancer." Thesis, University of Iowa, 2018. https://ir.uiowa.edu/etd/6424.

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Pharmacological ascorbate treatment (P-AscH-, high-dose, intravenous vitamin C) results in a short-term increased flux of H2O2 that is preferentially cytotoxic to cancer cells vs. normal cells. We hypothesized that there may be a sustained effect (> 24 h) of P-AscH- that may contribute to cytotoxicity. P-AscH- significantly increased sustained oxygen consumption (OCR), DCFH-DA oxidation, and extracellular acidification (ECAR) in tumor lines with no change in non-tumorigenic cells. One possible source of this sustained ROS and OCR, the NADPH oxidase family of enzymes Dual Oxidase 1 and 2 (DUOX)
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Jouravleva, Karina. "Telomere-driven chromosome instability impacts the genetic program through genome-wide epigenetic reprogramming." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066286.

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Le raccourcissement télomérique est la source majeure de l'instabilité chromosomique (CIN) au cours de la progression tumorale. Nous avons montré que les cellules humaines embryonnaires de rein (cellules HEK) ayant traversé une période de CIN subissent des vastes changements dans l'expression des microARNs, ce qui induit une transition épithélio-mésenchymateuse (TEM), un processus permettant aux cellules cancéreuses épithéliales migrer et envahir de nouveaux tissus et former des métastases. Notre travail a aussi suggéré que les cellules ayant subi une TEM étaient capables de former des tumeurs
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Jouravleva, Karina. "Telomere-driven chromosome instability impacts the genetic program through genome-wide epigenetic reprogramming." Electronic Thesis or Diss., Paris 6, 2015. http://www.theses.fr/2015PA066286.

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Le raccourcissement télomérique est la source majeure de l'instabilité chromosomique (CIN) au cours de la progression tumorale. Nous avons montré que les cellules humaines embryonnaires de rein (cellules HEK) ayant traversé une période de CIN subissent des vastes changements dans l'expression des microARNs, ce qui induit une transition épithélio-mésenchymateuse (TEM), un processus permettant aux cellules cancéreuses épithéliales migrer et envahir de nouveaux tissus et former des métastases. Notre travail a aussi suggéré que les cellules ayant subi une TEM étaient capables de former des tumeurs
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Berrens, Rebecca V. "Role of small RNAs and chromatin in transposable element silencing during global demethylation." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/275980.

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DNA methylation entails the addition of a methyl group to the 5-carbon of the cytosine base of the DNA. This modification is important during many biological processes such as imprinting, X-chromosome inactivation, cell differentiation as well as silencing of transposable elements (TEs). DNA methylation is dynamic during early mammalian development, despite being a more static mark in somatic cells. Global hypomethylation is a hallmark of epigenetic reprogramming in mammalian primordial germ cells (PGCs), the early embryo and in naïve embryonic stem cells (ESCs). Genome integrity is crucial d
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Michelatti, Daniela. "Oncogenic enhancer reprogramming in triple negative breast cancer tumour progression." Doctoral thesis, Università degli studi di Trento, 2022. http://hdl.handle.net/11572/327998.

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Basal breast cancer is a heterogeneous disease whose unfavourable outcome is determined by a high risk of tumour relapse and metastasis formation. The potential of a cancer cell to adapt to foreign environments is favoured by oncogenic cell plasticity, which is supported by epigenetic reprogramming. It was previously demonstrated that MYC acts as an oncogenic reprogramming factor by inducing epigenetic rewiring at enhancers (Poli et al., 2018). This causes the activation of oncogenic pathways and pro-metastatic transcription factors such as SOX9, but scant pieces of evidence support a causal l
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Popp, Christian. "Investigating the role of the cytidine deaminase AID in epigenetic reprogramming in the germline." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608864.

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Loke, Justin Ching Ting. "Identification of common and distinct epigenetic reprogramming properties of core-binding factor fusion proteins." Thesis, University of Birmingham, 2017. http://etheses.bham.ac.uk//id/eprint/7298/.

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RUNX1, also known as CBFa, is a master regulator of haematopoiesis. In Acute Myeloid Leukaemia (AML) it is frequently disrupted by translocations to different epigenetic regulators, resulting in the expression of core-binding factor fusion proteins. We compared the chromatin landscape of t(8;21) and t(3;21) AML which express RUNX1-ETO and RUNX1-EVI1, respectively. We found that the diverse clinical outcomes of patients with these two forms of AML are reflected in fundamental differences in gene expression and chromatin landscape. Despite both fusion proteins sharing a RUNT DNA binding domain,
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Kutschat, Ana Patricia [Verfasser]. "Gemcitabine Resistance Elicits a Calcium Dependent Epigenetic Reprogramming in Pancreatic Cancer / Ana Patricia Kutschat." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2021. http://d-nb.info/1229692126/34.

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31

Perikala, V. "Understanding the relevance of epigenetic reprogramming for resistance to HDAC inhibitors in cancer cells." Thesis, University of Liverpool, 2016. http://livrepository.liverpool.ac.uk/3004805/.

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Therapeutic responses to Histone deacetylase (HDAC) inhibitors (HDACi) in many cancers are well described but development of resistance to HDACi is a major stumbling block. Whether HDACis induce epigenetic reprogramming and how this contributes to relapse is not reported. A CTCL cell line HuT78, and a CLL cell line MEC1, were used to develop HDACi resistant clones (RHuT78 and RMEC1 respectively) that persistently grow in the presence of the clinically used HDAC inhibitor Romidepsin. RHuT78 cells show perturbed trimethylation of histone H3 lysine K4 on Romidepsin treatment which linked to highe
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Davis, Aaron Patrick. "Apoptotic and Epigenetic Induction of Embryo Failure Following Somatic Cell Nuclear Transfer." DigitalCommons@USU, 2013. https://digitalcommons.usu.edu/etd/1941.

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Somatic cell nuclear transfer (SCNT) is a useful tool for selective breeding, conservation, and production of transgenic animals. Despite the successful cloning of several species, high rates of embryo failure following SCNT prevent the wide-scale use of the technique. Embryos produced through cloning have a higher incidence of developmental arrest, decreased developmental potential, frequent implantation failures, and increased incidence of abortion. The objective of this dissertation research was to characterize the factors that lead to SCNT failures by examining epigenetic and apoptotic
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XIERAILI, AOBULI. "IDENTIFICATION OF EPIGENETIC INHIBITORS OF PHYSIOLOGICAL CELLULAR PLASTICITY AS NOVEL TUMOR SUPPRESSOR." Doctoral thesis, Università degli Studi di Milano, 2019. http://hdl.handle.net/2434/609578.

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Cellular plasticity, the inter-conversion of cells between differentiated cells and stem cells (SCs), can lead to tissue regeneration and restoration of homeostasis after injury. Conversely, inappropriate induction of cellular plasticity could be involved in tumor initiation and progression, through de-novo generation of cancer stem cells (CSCs) by de-differentiation of normal or non-tumorigenic bulk tumor cells. This intrinsically dangerous potential must be tightly controlled by genetic and epigenetic mechanisms, to prevent unscheduled de-differentiation. However, their systematic identifica
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Köhler, Daniela. "Cloning in cattle : nuclear architecture and epigenetic status of chromatin during reprogramming of donor cell nuclei." kostenfrei, 2008. http://edoc.ub.uni-muenchen.de/9915/.

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Hajkova, Petra [Verfasser], Harald [Gutachter] Saumweber, Jörn E. [Gutachter] Walter, and Wolf [Gutachter] Reik. "Epigenetic reprogramming in mouse germ cells / Petra Hajkova ; Gutachter: Harald Saumweber, Jörn E. Walter, Wolf Reik." Berlin : Humboldt-Universität zu Berlin, 2004. http://d-nb.info/1207678422/34.

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POLI, VITTORIA. "MYC agisce da fattore di riprogrammazione tumorale tramite induzione di uno stato di staminalità cellulare in cellule epiteliali umane della ghiandola mammaria." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2016. http://hdl.handle.net/10281/117389.

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Cancer is both a genetic and an epigenetic disease whose outcome is influenced by tumor microenvironment. These three determinants represent the major driving forces of tumorigenesis and cause the functional heterogeneity observed in most of the cancer types. Both normal and neoplastic cell populations are known to harbor subpopulations of Stem Cells (SCs) that can both self-renew and spawn more differentiated progeny that, in the case of cancer, forms the tumor bulk. For what concerns Cancer Stem Cells (CSCs), they are proposed to held most of the tumor initiating potential and a higher propo
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VECELLIO, MATTEO LUCA. "Differentiation and reprogrammig of human mesenchymal stromal cells: insights from epigenetic assessments and pre-clinical studies." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2012. http://hdl.handle.net/10281/30253.

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Mesenchymal stromal cells (StC) are cells with plastic properties virtually present in every adult tissue. Recently, StC have also been isolated from adult human cardiac tissue (CStC) and the hypothesis has been raised that StC deriving from the heart may be genetically committed to cardiovascular differentiation. In this light, the enhancement of CStC cardiovascular precursor properties may represent a potentially successful strategy for cardiac regeneration purposes. Although of adult origin, CStC exhibit Islet1 expression and respond to chemically-determined cardiogenic epigenetic stimuli.
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BIANCHI, ENRICA. "Controllo traduzionale dell'espressione genica all'inizio dell'embriogenesi." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2009. http://hdl.handle.net/2108/762.

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L’embriogenesi iniziale è un ottimo esempio di acquisizione della totipotenza da parte di una cellula staminale a partire da cellule terminalmente differenziate. I gameti sono cellule aploidi non più in grado di dividersi, che dopo la fecondazione uniscono il loro genoma convertendolo in uno embrionale. Lo zigote deve riprendere il ciclo cellulare mitotico, rimodellare la cromatina, attivare la trascrizione e iniziare il programma di sviluppo embrionale, che richiede l’acquisizione della totipotenza dei blastomeri. In diversi organismi modello l’attivazione traduzionale di RNA messaggeri mate
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Chen, Zhaoyi. "Modeling Defective Epigenetic Inheritance in Vascular Aging Using Hutchinson-Gilford Progeria Syndrome Vascular Smooth Muscle Cells." Thesis, Université d'Ottawa / University of Ottawa, 2020. http://hdl.handle.net/10393/41096.

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Cardiovascular disease (CVD) is the leading cause of death due to its prevalence in tandem with the propensity of atherosclerosis to worsen and cause myocardial infarction and stroke. The greatest risk factor for CVD development is age. The multifactorial etiology of atherosclerosis has made CVD difficult to model and consequently little is known about CVD onset and progression. Hutchinson-Gilford Progeria Syndrome (HGPS) is a severe human premature aging disorder caused by a mutation in Lamin A that leads to the accumulation of an aberrant Lamin A protein termed progerin. Patients who har
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Collier, Amanda. "Characterising the reprogramming dynamics between human pluripotent states." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/287952.

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Human pluripotent stem cells (hPSCs) exist in multiple states of pluripotency, broadly categorised as naïve and primed states. These provide an important model to investigate the earliest stages of human embryonic development. Naïve cells can be obtained through primed-to-naïve reprogramming; however, there are no reliable methods to prospectively isolate unmodified naïve cells during this process. Moreover, the current isolation strategies are incompatible for enrichment of naïve hPSCs early during reprogramming. Consequently, we know very little about the temporal dynamics of transcript
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FARIA, PEREIRA MARLENE CRISTINA. "EPIGENETIC AND FUNCTIONAL ASSESSMENT OF ENHANCEROPATHIES ACROSS HUMAN MODELS: FOCUS ON GABRIELE-DE VRIES SYNDROME." Doctoral thesis, Università degli Studi di Milano, 2022. https://hdl.handle.net/2434/945230.

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Yin Yang 1 (YY1) is a ubiquitous zinc finger transcription factor (TF) that occupies active enhancers and promoters contributing to physical interactions between these regions via DNA looping. Increasing evidence shows that disruption of non-coding regions such as enhancers is prevalent across different neurodevelopmental disorders (NDDs) with intellectual disability (ID) features. Indeed, YY1 haploinsufficiency causes a NDD with ID, named Gabriele-de Vries syndrome (GADEVS). Although it is known that YY1 controls the expression of a dazzling list of genes and influences various cellular proce
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42

Leong, Yeh Chwan. "Reprogramming to cancer induced pluripotent stem cells elucidates the contribution of genetic and epigenetic alterations to breast carcinogenesis." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/53330/.

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The induced pluripotent stem cells (iPSCs) technology has revolutionized disease modelling by enabling the generation of patient-specific pluripotent stem cells for the study of complex disorders such as cancer. Somatic cell reprogramming through iPSCs induces global epigenetic reconfiguration of the chromatin which converts cancer cells to an embryonic stem cell-like state with potential reversion of tumorigenicity. Therefore, reprogramming can be used to answer the question as to whether epigenetic alterations alone can be sufficient to induce carcinogenesis, independent of genetic defects.
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Lucas, Emma S. "Defining global DNA methylation differences betwen embryonic stem cells and fibroblasts for exploitation in Epigenetic reprogramming in vitro." Thesis, University of Nottingham, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.519395.

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44

Saadeh, Heba. "The role of DNA sequence signals in the epigenetic reprogramming of CpG islands during oogenesis and early embryogenesis." Thesis, King's College London (University of London), 2014. https://kclpure.kcl.ac.uk/portal/en/theses/the-role-of-dna-sequence-signals-in-the-epigenetic-reprogramming-of-cpg-islands-during-oogenesis-and-early-embryogenesis(76174739-3129-4655-b3f7-a72a9ea9a11a).html.

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The reprogramming of epigenetic marks is a genome-wide process and yet CpG islands escape the overall trend. In addition, not all CpG islands behave in the same way. While the majority of CpG islands resist the de novo DNA methylation establishment in the germ lines, ~1600 CpG islands acquire methylation during oogenesis. The majority of these oocyte-methylated CpG islands remain un-methylated during spermatogenesis, that is, they are maternal germ line differentially methylated regions (maternal gDMRs). All but 25 (permanent) maternal gDMRs lose their methylation post fertilisation and pre-im
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Abdallah, Hussein(Hussein M. ). "The core mammalian pluripotency network in induced pluripotent stem cell (iPSC) formation : models for genetic and epigenetic reprogramming." Thesis, Massachusetts Institute of Technology, 2018. https://hdl.handle.net/1721.1/122910.

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This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Thesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2018<br>Cataloged from student-submitted PDF version of thesis. "February 2018."<br>Includes bibliographical references (pages 23-37).<br>In 2006, history was made in a seminal experiment that converted mouse fibroblasts to a pluripotent phenotype coined the 'induced pluripotent stem cell' (iPSC) state. Unhindered by ethical or immuno
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Dubé, Delphine. "Différence dans la capacité de fibroblastes à être reprogrammés par le cytoplasme de l'ovocyte : étude d'une situation différentielle chez le bovin." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS252.

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La reprogrammation, qui est la réversion d’un noyau d’un état somatique vers un état moins différencié, constitue un enjeu majeur pour la thérapie cellulaire. Cependant, les mécanismes initiaux qui président à la reprogrammation restent mal connus. Le transfert nucléaire (clonage) met à profit les propriétés de reprogrammation uniques du cytoplasme ovocytaire, et constitue une approche expérimentale intéressante pour analyser ces processus. Le but de cette thèse est d’étudier la différence de capacité de cellules fibroblastiques à être reprogrammées efficacement, en tirant partie d’une situati
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Yamashiro, Chika. "Generation of human oogonia from induced pluripotent stem cells in vitro." Kyoto University, 2019. http://hdl.handle.net/2433/242826.

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48

Shimamoto, Ren. "Generation and Characterization of Induced Pluripotent Stem Cells from Aid-deficient Mice." Kyoto University, 2014. http://hdl.handle.net/2433/189672.

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Shimamoto R, Amano N, Ichisaka T, Watanabe A, Yamanaka S, et al. (2014) Generation and Characterization of Induced Pluripotent Stem Cells from Aid-Deficient Mice. PLoS ONE 9(4): e94735. doi:10.1371/journal.pone.0094735<br>Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(医科学)<br>甲第18515号<br>医科博第56号<br>新制||医科||4(附属図書館)<br>31401<br>京都大学大学院医学研究科医科学専攻<br>(主査)教授 斎藤 通紀, 教授 平家 俊男, 教授 山田 泰広<br>学位規則第4条第1項該当
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Payne, Kyle K. "Immunotherapy of Cancer: Reprogramming Tumor/Immune Cellular Crosstalk to Improve Anti-Tumor Efficacy." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3939.

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Immunotherapy of cancer has been shown to be promising in prolonging patient survival. However, complete elimination of cancer and life-long relapse-free survival remain to be major challenge for anti-cancer therapeutics. We have previously reported that ex vivo reprogramming of tumor-sensitized immune cells by bryostatin 1/ionomycin (B/I) and the gamma-chain (γ-c) cytokines IL-2, IL-7, and IL-15 resulted in the generation of memory T cells as well as CD25+ NKT cells and CD25+ NK cells. Adoptive cellular therapy (ACT) utilizing these reprogrammed immune cells protected FVBN202 mice from tumor
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Tiwari, Vijay Kumar. "The Epigenetics of Gene Transcription and Higher Order Chromatin Conformation." Doctoral thesis, Uppsala universitet, Zoologisk utvecklingsbiologi, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6302.

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It is becoming increasingly clear that long-range control of gene expression is mediated through direct physical interactions between genes and regulatory elements, either intra- or interchromosomally. In addition to transcriptional initiation, formation of active chromatin hubs seem to be crucial for increased transcriptional efficiency as well as insulation from neighbouring heterochromatic environment. Regulatory factors apparently have an important role in organization of such functional modules in a development and differentiated- dependent fashion. The relevance of trans-acting factors i
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