Auswahl der wissenschaftlichen Literatur zum Thema „Ewing T“

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Zeitschriftenartikel zum Thema "Ewing T"

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Maharjan, Yunash, Adriana C. Tufino, Sreya Dey, Elina Mukherjee, and Kelly M. Bailey. "Abstract B048: Galectin-3 regulation of immunosuppression in Ewing sarcoma." Cancer Research 84, no. 17_Supplement (2024): B048. http://dx.doi.org/10.1158/1538-7445.pediatric24-b048.

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Abstract Objective: Ewing sarcoma is a fusion oncoprotein-driven cancer most commonly diagnosed in adolescents. Utilizing single-cell RNAseq of human Ewing tumors, we have previously demonstrated that Galectin-3, an immunosuppressive lectin family member protein, is expressed in both Ewing tumor cells and in CD8 T cells in the Ewing tumor microenvironment, a finding not noted in CD8 T cells infiltrating osteosarcomas. Galectin-3 serves to modulate tumor immunobiology through multiple mechanisms, including interactions with the immune checkpoint protein LAG3. In addition to Galectin-3, Galectin
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Petit, Floriane, Ana Lalanne, Céline Collin, Joshua Waterfall, Olivier Lantz, and Olivier Delattre. "Abstract IA021: Neogenes induced by oncogenic chimeric transcription factors as potential targets for therapy." Cancer Research 84, no. 17_Supplement (2024): IA021. http://dx.doi.org/10.1158/1538-7445.pediatric24-ia021.

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Abstract We recently showed that oncogenic chiemeric transcription factors (OCTF) of various pediatric cancers induce the expression of highly tumor-specific long intergenic non coding RNAs which are not expressed in normal tissues and which we called neogenes. Since recent reports indicate that such LincRNA may not be as non-coding as initially thought we sought for potential peptides encoded by these neogenes. Using the EWSR1::FLI1 chimera of Ewing sarcoma as a paradigm of such chimeras and through Riboseq profiling and whole cell proteomics we indeed show that some of these neogenes encode
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Karaman, Ivo. "North American sironids (Opiliones, Cyphophthalmi) and composition of the family Sironidae with a description of two new species." Biologia Serbica 44, no. 2 (2022): 51–77. https://doi.org/10.5281/zenodo.7489147.

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<strong>Summary. </strong>A revised composition of the family Sironidae is given. Two North American genera, namely <em>Holosiro</em> Ewing, 1923 and <em>Neosiro</em> Newell, 1943, are resurrected, one new genus, <em>Arhesiro</em> gen. nov., a subgenus, <em>Tillamooksiro</em> sbg. nov., and two new species, <em>Holosiro</em> <em>ewingi</em> sp. n. and <em>Neosiro </em>(<em>T</em>.)<em> martensi</em> sp. n. are described. Diagnostic characters of Cyphophthalmi families are presented and discussed.
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Hilterman, Fred. "Maurice Ewing Medal for T. R. LaFehr." Leading Edge 17, no. 3 (1998): 385. http://dx.doi.org/10.1190/tle17030385.1.

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Maharjan, Yunash, Sreya Dey, Elina Mukherjee, Jessica Daley, and Kelly M. Bailey. "Abstract 5464: Galectin-3 expression in Ewing sarcoma: Modulation of the immune microenvironment in an immunocompetent model." Cancer Research 84, no. 6_Supplement (2024): 5464. http://dx.doi.org/10.1158/1538-7445.am2024-5464.

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Abstract Objective: Ewing sarcoma is an aggressive cancer of adolescents. Patients with metastatic Ewing sarcoma often receive radiation as part of their treatment protocol. We have demonstrated that both Ewing tumor cells and T cells infiltrating Ewing tumors express Galectin-3 (Gal3), an immunosuppressive protein in the tumor microenvironment. Here, we utilize an immunocompetent, humanized mouse model of Ewing sarcoma to investigate the role of Galectin-3 in the Ewing tumor immune microenvironment both at baseline and following radiation. Specifically, we sought to determine the influence of
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Morales, Erin, Michael Olson, Fiorella Iglesias, Saurabh Dahiya, Tim Luetkens, and Djordje Atanackovic. "Role of immunotherapy in Ewing sarcoma." Journal for ImmunoTherapy of Cancer 8, no. 2 (2020): e000653. http://dx.doi.org/10.1136/jitc-2020-000653.

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Ewing sarcoma (ES) is thought to arise from mesenchymal stem cells and is the second most common bone sarcoma in pediatric patients and young adults. Given the dismal overall outcomes and very intensive therapies used, there is an urgent need to explore and develop alternative treatment modalities including immunotherapies. In this article, we provide an overview of ES biology, features of ES tumor microenvironment (TME) and review various tumor-associated antigens that can be targeted with immune-based approaches including cancer vaccines, monoclonal antibodies, T cell receptor-transduced T c
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Miller, Henry E., Aparna Gorthi, Nicklas Bassani, Liesl A. Lawrence, Brian S. Iskra, and Alexander J. R. Bishop. "Reconstruction of Ewing Sarcoma Developmental Context from Mass-Scale Transcriptomics Reveals Characteristics of EWSR1-FLI1 Permissibility." Cancers 12, no. 4 (2020): 948. http://dx.doi.org/10.3390/cancers12040948.

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Ewing sarcoma is an aggressive pediatric cancer of enigmatic cellular origins typically resulting from a single translocation event t (11; 22) (q24; q12). The resulting fusion gene, EWSR1-FLI1, is toxic or unstable in most primary tissues. Consequently, attempts to model Ewing sarcomagenesis have proven unsuccessful thus far, highlighting the need to identify the cellular features which permit stable EWSR1-FLI1 expression. By re-analyzing publicly available RNA-Sequencing data with manifold learning techniques, we uncovered a group of Ewing-like tissues belonging to a developmental trajectory
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NORTON, ROY A., and SERGEY G. ERMILOV. "Identity of the oribatid mite Oribata curva and transfer to Trichogalumna (Acari, Oribatida, Galumnidae), with discussion of nomenclatural and biogeographical issues in the ‘curva’ species-group." Zootaxa 4272, no. 4 (2017): 551. http://dx.doi.org/10.11646/zootaxa.4272.4.4.

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Based on the study of type material, other historical specimens, and new collections, the adult of the thelytokous oribatid mite Oribata curva Ewing, 1907 (Galumnidae) is redescribed and the name is recombined to Trichogalumna curva (Ewing, 1907) comb. nov. A confusing history of synonymies and misidentifications is traced in detail, and their effect on published statements about biogeography is assessed. Reliable records of T. curva are only those from North America. The tropical mite Pergalumna ventralis (Willmann, 1932) is not a subspecies of T. curva. The widely-reported Trichogalumna nipp
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Zhou (Joe) Huang, Yue, Melanie Rouleu, and Poul Sorensen. "Abstract B053: Tumor-associated macrophages diminishes IL1RAP-targeting CAR-T cell therapy efficacy in Ewing sarcoma." Cancer Research 84, no. 17_Supplement (2024): B053. http://dx.doi.org/10.1158/1538-7445.pediatric24-b053.

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Abstract Ewing sarcoma (EwS) is a pediatric malignancy of soft tissue and bone with a poor prognosis, especially in its metastatic stages. We have previously identified IL1RAP as a promising target for immunotherapies like chimeric antigen receptor (CAR) T cell therapy against EwS. However, CAR-T cells, despite their success in hematological cancers, often show limited efficacy against solid tumors. In orthotopic xenograft models of Ewing sarcoma (EwS) we have observed that CD11b+ CD206+ macrophages, known as tumor-associated macrophages (TAMs), surround the primary tumor. Treatment with IL1RA
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Daley, Jessica D., Elina M. Mukherjee, Anthony R. Cillo, et al. "Abstract A004: Radiation-induced changes to the immune microenvironment in an immunocompetent mouse model of Ewing sarcoma." Clinical Cancer Research 28, no. 18_Supplement (2022): A004. http://dx.doi.org/10.1158/1557-3265.sarcomas22-a004.

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Abstract Background: Ewing sarcoma is a rare, aggressive, fusion oncoprotein-driven pediatric cancer. Patients with upfront metastatic or surgically unresectable disease commonly undergo radiation as part of standard of care therapy. Currently, little is known about the effect of radiation specifically on the immune microenvironment of Ewing tumors, as no routine biopsies or other clinical samples are acquired during radiation. Further, historically, the field has lacked an immunocompetent mouse model of Ewing sarcoma in which to study Ewing tumor-immune cell interactions. Given our interest i
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Dissertationen zum Thema "Ewing T"

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Müller-Spahn, Christina [Verfasser], Stefan [Akademischer Betreuer] Burdach, Günther [Akademischer Betreuer] Richter, and Angela [Akademischer Betreuer] Krackhardt. "Interleukin-21 mediated generation of allorestricted central memory cytotoxic T cells directed against Ewing tumour-specific antigens / Christina Müller-Spahn. Gutachter: Stefan Burdach ; Angela Krackhardt. Betreuer: Stefan Burdach ; Günther Richter." München : Universitätsbibliothek der TU München, 2014. http://d-nb.info/1059872943/34.

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Schirmer, David [Verfasser], Günther H. S. [Akademischer Betreuer] Richter, Stefan [Gutachter] Burdach, and Angela [Gutachter] Krackhardt. "Generation of transgenic, antigen-specific, allogeneic, HLA-A*02:01-restricted, cytotoxic T cells directed against Ewing Sarcoma specific target antigen STEAP1 / David Schirmer. Betreuer: Günther H. S. Richter. Gutachter: Stefan Burdach ; Angela Krackhardt." München : Universitätsbibliothek der TU München, 2016. http://d-nb.info/1105646564/34.

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Gerdes, Janna Henrieke [Verfasser], Günther [Akademischer Betreuer] Richter, Günther [Gutachter] Richter, and Stefan [Gutachter] Burdach. "Generation transgener, antigen-spezifischer, allogener, HLA-A*02:01 restringierter, zytotoxischer T-Zellen gerichtet gegen das für das Ewing Sarkom spezifische Antigen HOXD11 / Janna Henrieke Gerdes ; Gutachter: Günther Richter, Stefan Burdach ; Betreuer: Günther Richter." München : Universitätsbibliothek der TU München, 2020. http://d-nb.info/1231434465/34.

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Kirschner, Andreas Manfred Verfasser], Stefan [Akademischer Betreuer] [Gutachter] Burdach, de Angelis Martin [Gutachter] [Hrabé, and Elfriede [Gutachter] Nößner. "Characterization and Cloning of Ewing Sarcoma Selective HLA-A*02:01 Restricted T Cell Receptors Directed Against ADRB3 and PAPPA / Andreas Manfred Kirschner ; Gutachter: Martin Hrabé de Angelis, Elfriede Nößner, Stefan Burdach ; Betreuer: Stefan Burdach." München : Universitätsbibliothek der TU München, 2017. http://d-nb.info/1140165887/34.

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Pirson, Stefan [Verfasser]. "Generation of autologous and allorestricted cytotoxic T cell clones directed against Ewing tumor antigens / Stefan Pirson." 2009. http://d-nb.info/1000442713/34.

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Bücher zum Thema "Ewing T"

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Transportation, United States Congress House Committee on Public Works and. Ewing T. Kerr United States Courthouse: Report (to accompany S. 1889) (including cost estimate of the Congressional Budget Office). U.S. G.P.O., 1992.

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Mease, James. Inaugural Dissertation on the Disease Produced by the Bite of a Mad Dog, or Other Rabid Animal: Submitted to the Examination of the Rev. John Ewing, S. T. P. Provost. Creative Media Partners, LLC, 2018.

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Chisolm, Robert. Inaugural Dissertation on the Hydrocephalus Internus, or Internal Dropsy of the Brain. Submitted to the Examination of the Rev. John Ewing, S. T. P. Provost, the Trustees and Medical Faculty of the University of Pennsylvania. Creative Media Partners, LLC, 2018.

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Glasgow, Merchants House of. View of the Merchants House of Glasgow: Containing Historical Notices of Its Origin, Constitution, and Property, and of the Charitable Foundations Which It Administers. Presented to the House by Archibald Orr Ewing, Esquire of Ballikinrain, Lord Dean of T. Creative Media Partners, LLC, 2023.

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Glasgow, Merchants House of. View of the Merchants House of Glasgow: Containing Historical Notices of Its Origin, Constitution, and Property, and of the Charitable Foundations Which It Administers. Presented to the House by Archibald Orr Ewing, Esquire of Ballikinrain, Lord Dean of T. Creative Media Partners, LLC, 2023.

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Meredith, Charles D. 1831. Inaugural Dissertation on Phthisis Pulmonalis; Submitted to the Examination of the Rev. John Ewing, S. T. P. Provost, the Trustees and Medical Faculty of the University of Pennsylvania; on the Twenty-Seventh Day of May, 1802. for the Degree of Doctor... Creative Media Partners, LLC, 2021.

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Cutbush, Edward 1772-1843. Inaugural Dissertation on Insanity: Submitted to the Examination of the Rev. John Ewing, S. T. P. Provost; the Trustees and Medical Professors of the University of Pennsylvania; for the Degree of Doctor of Medicine, on the Nineteenth Day of May, A. D... . Creative Media Partners, LLC, 2021.

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Buchteile zum Thema "Ewing T"

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Bannerman, Gordon. "H. E. Crum-Ewing to Earl Granville, 29 November 1880; H. E. Crum-Ewing to Joseph Chamberlain, 29 November 1880; Evelyn Ashley to Messrs. Monteith & Kelly, 2 December 1880; Evelyn Ashley to T. D. Hill, 2 December 1880." In Politics and Trade in Britain, 1776-1914. Routledge, 2023. http://dx.doi.org/10.4324/9781003098140-4.

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Osman, Kim, Amber Marshall, and Michael Dezuanni. "Digital Inclusion and Learning at Home: Challenges for Low-Income Australian Families." In Palgrave Studies in Digital Inequalities. Springer International Publishing, 2024. http://dx.doi.org/10.1007/978-3-031-28930-9_5.

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AbstractThe sudden switch to learning exclusively at home during the COVID-19 pandemic revealed the extent of low levels of digital inclusion for many low-income and socially disadvantaged families and children in Australia. Many students and families struggled with access to, and the affordability of, devices and data, along with having the required digital skills and mentoring to learn at home. The Australian Government recognises that “socially vulnerable children are over-represented among the group of students who are educationally vulnerable” and the Australian Digital Inclusion Index sh
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"Introduction: Michael T. Ewing." In Social Marketing. Routledge, 2012. http://dx.doi.org/10.4324/9780203049174-5.

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Holden Reid, Brian. "Unfortunate Civilian, 1853–1861." In The Scourge of War. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780195392739.003.0004.

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This chapter examines William T. Sherman’s experience as a banker in San Francisco, California. With his customary thoroughness, Sherman studied business practices carefully. He viewed the trust placed in him with an elevated sense of moral responsibility not widely shared by other San Francisco bankers. The system knew no regulation; laissez faire in its most extreme form prevailed. So, in the best military fashion, Sherman laid down a series of principles to determine his conduct. These reveal the workings of his mind and broader mental affinities. Sherman had really re-dedicated himself to
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Dancy, Jonathan. "Should We Pass the Buck?" In Practical Thought. Oxford University Press, 2021. http://dx.doi.org/10.1093/oso/9780198865605.003.0015.

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This paper is a historically informed and critical assessment of T. Scanlon’s ‘buck-passing’ conception of value, under which for an object to be of value is for it to have features that give us reasons to respond to it in certain characteristic ways. It starts by giving a fairly detailed account of the history of such views in British moral philosophy (mainly at the hands of Ross, Joseph, and Ewing), which raises the question where the novelty lies in Scanlon’s presentation. It also questions the strength of arguments in favour of buck-passing given by Scanlon and Parfit, and gives some reaso
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Howard, Christopher. "The Fundamentality of Fit." In Oxford Studies in Metaethics Volume 14. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780198841449.003.0010.

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Many authors, including Derek Parfit, T. M. Scanlon, and Mark Schroeder, favor a “reasons-first” ontology of normativity, which treats reasons as normatively fundamental. Others, most famously G. E. Moore, favor a “value-first” ontology, which treats value or goodness as normatively fundamental. Chapter 10 argues that both the reasons-first and value-first ontologies should be rejected because neither can account for all of the normative reasons that, intuitively, there are. It advances an ontology of normativity, originally suggested by Franz Brentano and A. C. Ewing, according to which fitti
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Veligorsky, Georgy A. "“A Green Thought in a Green Shade”: The Influence of English Metaphysical Poets on the Children’s Literature of the Victorian Era." In Beyond Borders: In Memory of Andrey Kofman. A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, 2025. https://doi.org/10.22455/978-5-9208-0803-5-337-361.

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The article examines the influence of English metaphysical poets of the 16th and 17th centuries (A. Marvell, G. Vaughan, T. Traherne, J. Herbert) on the children’s “estate” novel of the Victorian era. We will analyze for what purpose the children’s writers (M. Gatty, J.H. Ewing et al.) introduce the appropriate intertext into their novels and stories (to emphasize the unsteadiness of the world; to create “volatile” nostalgic images; depicting the estate as an earthly paradise, etc.). We will also discuss the quotes they use (both as epigraphs and included in the fabric of the narrative), as we
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García-Wistädt, Ingrid. "“Willst du ewig schlafen?” La evocación del vampiro en el romanticismo alemán." In Literatura fantástica alemana E,T,A, Hoffmann y su legado. Dykinson, 2023. https://doi.org/10.2307/jj.11103002.11.

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Konferenzberichte zum Thema "Ewing T"

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Kailayangiri, Sareetha, Bianca Altvater, Jutta Meltzer, et al. "Abstract 4754: Targeting of Ewing sarcoma by CAR-reengineered GD2-specific T cells." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-4754.

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Thiel, Uwe, Sebastian Schober, ingo Einspieler, et al. "Abstract 3757: Ewing Sarcoma regression by Allo-MHC/Chm1 specific T cells without GVHD." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-3757.

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Thiel, Uwe, Sebastian J. Schober, Ingo Einspieler, et al. "Abstract B38: Ewing sarcoma regression without GVHD by allo-MHC/CHM1 specific T cells." In Abstracts: Advances in Sarcomas: From Basic Science to Clinical Translation; May 16-19, 2017; Philadelphia, PA. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1557-3265.sarcomas17-b38.

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Schirmer, David, Isabel Storz, Karin Wisskirchen, et al. "Abstract A09: GPR64-specific CAR-transgenic T cells selectively kill Ewing sarcoma in vivo." In Abstracts: AACR Special Conference: Pediatric Cancer Research: From Basic Science to the Clinic; December 3-6, 2017; Atlanta, Georgia. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.pedca17-a09.

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Thiel, Uwe, Andreas Kirschner, Melanie Thiede, et al. "Abstract 692: Pappalysin-1 is a suitable target for T cell receptor transgenic T cells to kill Ewing sarcomain vivoandin vitro." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-692.

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Panisello, C., C. Bueno, C. Castilla, et al. "An innovative tailored CAR T cell-redirecting immunotherapy for the treatment of metastatic and refractory Ewing Sarcoma." In 34. Jahrestagung der Kind-Philipp-Stiftung für pädiatrisch onkologische Forschung. Georg Thieme Verlag, 2023. http://dx.doi.org/10.1055/s-0043-1768534.

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Panisello, C., R. Aschero, H. Roca-Ho, et al. "An innovative tailored CAR T cell-redirecting immunotherapy for the treatment of metastatic and refractory Ewing Sarcoma." In 35. Jahrestagung der Kind-Philipp-Stiftung für pädiatrisch onkologische Forschung. Georg Thieme Verlag KG, 2024. http://dx.doi.org/10.1055/s-0044-1786604.

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Schober, Sebastian J., Melanie Thiede, David Schirmer, et al. "Abstract LB-106: Allorepertoire-derived HLA class I/peptide-specific T cell receptor transgenic CD4+T cells mediate antitumor responses in Ewing sarcoma mimicking allo-rejection." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-lb-106.

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Altvater, Bianca, Silke Landmeier, Sibylle Pscherer, Ilka Neumann, Heribert Juergens, and Claudia Rossig. "Abstract 1927: Induction of memory CD8+ T-cell responses to STEAP-1 specific peptides for immunotherapy of Ewing sarcoma." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-1927.

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Thiel, Uwe, Andreas Kirschner, Ingo Einspieler, and Stefan Burdach. "Abstract A81: Adoptively transferred Chondromodulin 1/HLA-A:0201 allo-restricted T cell receptor transgenic CD8+ T cells are well tolerated and cause partial regression in a patient with disseminated Ewing Sarcoma." In Abstracts: AACR Special Conference on Tumor Immunology and Immunotherapy; October 20-23, 2016; Boston, MA. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/2326-6074.tumimm16-a81.

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