Thematische Bibliographien / Exonic DNA methylation

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Auswahl der wissenschaftlichen Literatur zum Thema „Exonic DNA methylation“

Autor: Grafiati

Veröffentlicht am 25. Mai 2024

Zuletzt aktualisiert am 31. Juli 2025

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Zeitschriftenartikel zum Thema "Exonic DNA methylation"

Emon, Isaac M., Ruaa Al-Qazazi, Michael J. Rauh, and Stephen L. Archer. "The Role of Clonal Hematopoiesis of Indeterminant Potential and DNA (Cytosine-5)-Methyltransferase Dysregulation in Pulmonary Arterial Hypertension and Other Cardiovascular Diseases." Cells 12, no. 21 (2023): 2528. http://dx.doi.org/10.3390/cells12212528.

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DNA methylation is an epigenetic mechanism that regulates gene expression without altering gene sequences in health and disease. DNA methyltransferases (DNMTs) are enzymes responsible for DNA methylation, and their dysregulation is both a pathogenic mechanism of disease and a therapeutic target. DNMTs change gene expression by methylating CpG islands within exonic and intergenic DNA regions, which typically reduces gene transcription. Initially, mutations in the DNMT genes and pathologic DNMT protein expression were found to cause hematologic diseases, like myeloproliferative disease and acute

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Anastasiadou, Christina, Andigoni Malousi, Nicos Maglaveras, and Sofia Kouidou. "Human Epigenome Data Reveal Increased CpG Methylation in Alternatively Spliced Sites and Putative Exonic Splicing Enhancers." DNA and Cell Biology 30, no. 5 (2011): 267–75. http://dx.doi.org/10.1089/dna.2010.1094.

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Chen, Xiaona, Xinyu Duan, Qingqing Chong, Chunqing Li, Heng Xiao, and Shanyuan Chen. "Genome-Wide DNA Methylation Differences between Bos indicus and Bos taurus." Animals 13, no. 2 (2023): 203. http://dx.doi.org/10.3390/ani13020203.

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Disease risk is a persistent problem in domestic cattle farming, while economic traits are the main concern. This study aimed to reveal the epigenetic basis for differences between zebu (Bos indicus) and taurine cattle (Bos taurus) in disease, disease resistance, and economic traits, and provide a theoretical basis for the genetic improvement of domestic cattle. In this study, whole genome bisulfite sequencing (WGBS) was used to analyze the whole-genome methylation of spleen and liver samples from Yunnan zebu and Holstein cattle. In the genome-wide methylation pattern analysis, it was found th

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Park, Jee-Soo, Yun-Hee Shin, and Young-Doo Park. "DNA Methylation Level Changes in Transgenic Chinese Cabbage (Brassica rapa ssp. pekinensis) Plants and Their Effects on Corresponding Gene Expression Patterns." Genes 12, no. 10 (2021): 1563. http://dx.doi.org/10.3390/genes12101563.

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Plant tissue culture is an in vitro technique used to manipulate cells, tissues, or organs, and plays an important role in genetic transformation. However, plants cultured in vitro often exhibit unintended genetic and epigenetic variations. Since it is important to secure the stability of endogenous and exogenous gene expressions in transgenic plants, it is preferable to avoid the occurrence of such variations. In this study, we focused on epigenetic variations, exclusively on methylation level changes of DNA, in transgenic Chinese cabbage (Brassica rapa ssp. pekinensis) plants. To detect thes

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Xiao, Chunlin, and Valerie Schneider. "Abstract 3743: Genome-wide profiling of DNA N6-methylation from a breast cancer and a matched normal cell lines." Cancer Research 82, no. 12_Supplement (2022): 3743. http://dx.doi.org/10.1158/1538-7445.am2022-3743.

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Abstract DNA N6-methyladenine (m6A) modification has been found widely presented in the human genome, and genome-wide DNA methylation profiling in cancer may reveal epigenetic signatures with significant clinical outcomes. Whole genome sequencing data from PacBio single-molecule real-time (SMRT) system provides signals for identifying the presence of m6A in human genomic DNA. We identified 343,199 m6A modification sites with an average density of 122 per Mb in the HCC1395 breast cancer cell line, whereas 722,303 m6A modification sites with average density of 257 per Mb were observed in a match

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Yu, Xiying, Ying Teng, Xingran Jiang, Hui Yuan, and Wei Jiang. "Genome-Wide DNA Methylation Pattern of Cancer Stem Cells in Esophageal Cancer." Technology in Cancer Research & Treatment 19 (January 1, 2020): 153303382098379. http://dx.doi.org/10.1177/1533033820983793.

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Background: Cancer stem cells (CSCs) are considered the main cause of cancer recurrence and metastasis, and DNA methylation is involved in the maintenance of CSCs. However, the methylation profile of esophageal CSCs remains unknown. Methods: Side population (SP) cells were isolated from esophageal squamous cell carcinoma (ESCC) cell lines KYSE150 and EC109. Sphere-forming cells were collected from human primary esophageal cancer cells. SP cells and sphere-forming cells were used as substitutes for cancer stem-like cells. We investigated the genome-wide DNA methylation profile in esophageal can

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Verma, Pratima, Amrita Singh, Supriya Purru, Kangila Venkataramana Bhat, and Suman Lakhanpaul. "Comparative DNA Methylome of Phytoplasma Associated Retrograde Metamorphosis in Sesame (Sesamum indicum L.)." Biology 11, no. 7 (2022): 954. http://dx.doi.org/10.3390/biology11070954.

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Phytoplasma-associated diseases such as phyllody and little leaf are critical threats to sesame cultivation worldwide. The mechanism of the dramatic conversion of flowers to leafy structures leading to yield losses and the drastic reduction in leaf size due to Phytoplasma infection remains yet to be identified. Cytosine methylation profiles of healthy and infected sesame plants studied using Whole Genome Bisulfite Sequencing (WGBS) and Quantitative analysis of DNA methylation with the real-time PCR (qAMP) technique revealed altered DNA methylation patterns upon infection. Phyllody was associat

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Terp, Simone Karlsson, Karen Guldbrandsen, Malene Pontoppidan Stoico, et al. "Genome-Wide cfDNA Methylation Profiling Reveals Robust Hypermethylation Signatures in Ovarian Cancer." Cancers 17, no. 12 (2025): 2026. https://doi.org/10.3390/cancers17122026.

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Background: Ovarian cancer remains the most lethal gynecological cancer, primarily due to its asymptomatic nature in early stages and consequent late diagnosis. Early detection improves survival, but current biomarkers lack sensitivity and specificity. Cell-free DNA (cfDNA) released from tumor cells captures tumor-associated epigenetic alterations and represents a promising source for minimally invasive biomarkers. Among these, aberrant DNA methylation occurs early in tumorigenesis and may reflect underlying disease biology. This study aimed to investigate genome-wide cfDNA methylation profile

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Nishida, Hiromi. "Nucleosome Positioning." ISRN Molecular Biology 2012 (October 15, 2012): 1–5. http://dx.doi.org/10.5402/2012/245706.

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Nucleosome positioning is not only related to genomic DNA compaction but also to other biological functions. After the chromatin is digested by micrococcal nuclease, nucleosomal (nucleosome-bound) DNA fragments can be sequenced and mapped on the genomic DNA sequence. Due to the development of modern DNA sequencing technology, genome-wide nucleosome mapping has been performed in a wide range of eukaryotic species. Comparative analyses of the nucleosome positions have revealed that the nucleosome is more frequently formed in exonic than intronic regions, and that most of transcription start and

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Ackah, Michael, Liangliang Guo, Shaocong Li, et al. "DNA Methylation Changes and Its Associated Genes in Mulberry (Morus alba L.) Yu-711 Response to Drought Stress Using MethylRAD Sequencing." Plants 11, no. 2 (2022): 190. http://dx.doi.org/10.3390/plants11020190.

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Drought stress remains one of the most detrimental environmental cues affecting plant growth and survival. In this work, the DNA methylome changes in mulberry leaves under drought stress (EG) and control (CK) and their impact on gene regulation were investigated by MethylRAD sequencing. The results show 138,464 (37.37%) and 56,241 (28.81%) methylation at the CG and CWG sites (W = A or T), respectively, in the mulberry genome between drought stress and control. The distribution of the methylome was prevalent in the intergenic, exonic, intronic and downstream regions of the mulberry plant genome

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Dissertationen zum Thema "Exonic DNA methylation"

Yi, Jia. "The Role of Convergent Transcription in Regulating Alternative Splicing : Targeted Epigenetic Modification via Repurposed CRISPR/Cas9 System and Its Impact on Alternative Splicing Modulation." Electronic Thesis or Diss., Sorbonne université, 2020. http://www.theses.fr/2020SORUS382.

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L'épissage alternatif de l'ARN précurseur est un processus co-transcriptionnel qui affecte la grande majorité des gènes humains et contribue à la diversité des protéines. Le dérèglement d'un tel processus est impliqué dans diverses maladies, y compris la tumorigènes. Cependant, les mécanismes qui régulent ces processus restaient à caractériser. Dans cette étude, nous avons montré que les perturbations de l'épissage alternatif étaient corrélées aux dérèglements de la transcription convergente et de la méthylation de l'ADN. Une transcription convergente peut être générée entre des paires de gène

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Kamoun, Aurélie. "Caractérisation des cancers de vessie par l’analyse intégrative des données de puces exons." Thesis, Paris 11, 2013. http://www.theses.fr/2013PA11T007.

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Les rapides progrès technologiques en matière de techniques de biologie à grande échelle, comprenant notamment les microarrays, conduisent en 2006 au développement d’une nouvelle génération de puces à très haute résolution, capables de cibler à la fois tous les gènes du transcriptome humain, mais également tous les exons de ces gènes pris individuellement. L’avènement de cette puce, communément appelée puce exon, permit d’obtenir une mesure précise des changements transcriptomiques affectant les cellules cancéreuses, en offrant la possibilité de prendre en compte l’expression relative de diffé

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Buchteile zum Thema "Exonic DNA methylation"

Lucchesi, John C. "DNA methylation and gene expression." In Epigenetics, Nuclear Organization & Gene Function. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780198831204.003.0008.

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DNA methylation is an epigenetic modification that consists of the addition of a methyl, or of a hydroxyl and a methyl group, to the cytosine of CpG dinucleotides. Some gene promoters are rich in CpGs that are predominantly not modified; other promoters and most enhancers are poor in CpGs. These elements, as well as most exons, introns and intergenic regions, tend to be methylated. CpG methylation plays an important role in maintaining transposable elements and tandem arrays of repetitive sequences in a repressed state. CpG methylation is also responsible for the uniparental silencing of impri

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