Auswahl der wissenschaftlichen Literatur zum Thema „FEMUR BONE“

Background:The femur bone is an essential part of human activity, providing stability and support in carrying out our day to day activities. The inter-human anatomical variation and load bearing ability of humans of different heights will provide the necessary understanding of their functional ability.Objective:In this study, femur bone of two humans of different lengths (tall femur and short femur) were subjected to static structural loading conditions to evaluate their load-bearing abilities using Finite Element Analysis.Methods:The 3D models of femur bones were developed using MIMICS from the CT scans which were then subjected to static structural analysis by varying the load from 1000N to 8000N. The von Mises stress and deformation were captured to compare the performance of each of the femur bones.Results:The tall femur resulted in reduced Von-Mises stress and total deformation when compared to the short femur. However, the maximum principle stresses showed an increase with an increase in the bone length. In both the femurs, the maximum stresses were observed in the medullary region.Conclusion:When the applied load exceeds 10 times the body weight of the person, the tall femur model exceeded 134 MPa stress value. The short femur model failed at 9 times the body weight, indicating that the tall femur had higher load-bearing abilities.

The femur is the longest, heaviest, and strongest bone in the human body. Morphometric study of femur can be useful for estimation of stature, prediction of femur fractures/pathologies, operative management as well as for determination of congenital anomalies. 250 dry femur bones collected from bone Store, Government Medical College, Surat, Gujarat with study done over a period of 6 months. Total length of each femur and the Foraminal Index (FI) for each nutrient foramina were obtained. The mean total length of femur obtained was 41.22 cms. Torsion angle for both right sided as well as left sided femurs was most common in the range 11 - 14. 39.7% (48) of the total right sided femurs (121) had a torsion angle in the range 11 - 14 while 41.9% (54) of the total left sided femurs (129) also had a torsion angle in the range 11 - 14. Maximum number had a neck shaft angle in the range of 123 - 127 which constitutes 41.6% (104) of total sample size. Nutrient foramina was most commonly (48.8%) along linea aspera with most had a size corresponding to 22 gauge, which constitutes 45.7% (119) of total sample size. Morphometric study of femur helps us to determine various factors which could be helpful for prediction, prevention and diagnosis of a certain pathology as well as for its management and treatment.

Summary Aim: The aim of this study was to evaluate the normal distribution of sodium fluoride-18 (NaF-18) and to clarify the differences in uptake according to location and the type of the bone using positron emission tomography (PET) / computed tomography (CT). Methods: We retrospectively reviewed NaF-18 PET/CT images from 30 patients with hip joint disorders. PET/CT scans were performed 40 min after injection of approximately 185 MBq of NaF-18. To evaluate the relationship between the distribution of NaF-18 uptake and bone density, we compared the maximum standardised uptake values (SUVmax) on PET and the Hounsfield Units (HUs) on CT of the lumbar vertebra, ilium, and proximal and distal femurs. Regions of interests were defined both outside and inside the cortical bone to measure whole bone and cancellous bone only, respectively. Results: The distribution of NaF-18 differed according to the skeletal site. The lumbar vertebra showed the highest SUVmax for both whole bone and cancellous bone, followed by the ilium, proximal femur, and distal femur. The bones differed significantly in SUVmax. The distal femur showed the highest HU, followed by the proximal femur, ilium, and vertebra. Profile curve analyses demonstrated that the cancellous bones showed higher SUVmax and lower HU than the cortical bones. Conclusions: Our results demonstrate the difference in NaF-18 uptake between cancellous and cortical bones, which may explain differences in uptake by location. NaF-18 uptake does not appear to be strongly correlated with bone density, but rather with bone turnover and blood flow.

The effects of a 10-wk training regimen on the mechanical properties of the femur and humerus were evaluated in 2.5- and 25-mo-old Fischer 344 female rats. The rats trained on a rodent treadmill 5 days/wk for 10 wk. Duration, grade, and speed increased until the rats maintained 1 h/day at 15% grade and either 15 m/min (old rats) or 36 m/min (young rats). Excised bones were mechanically tested with a 3-point flexure test for mechanical properties of force, stress, and strain. Fat-free dry weight (FFW) and moment of inertia were also obtained. With aging, similar increases were observed in both the femur and humerus for FFW, moment of inertia, and force. Ultimate stress was reduced in the senescent femur while strain was elevated; a similar but nonsignificant trend was observed in the humerus. Irrespective of age, training increased FFW in the femur and, to a lesser degree, in the humerus. Breaking force was elevated for both bones after training. In young and old bones, the training-induced differences in bone mass and force were similar, despite differences in training intensity. In the old trained rats, femur ultimate stress was greater than that in control rat femurs and similar to that in young rat femurs. The results of the present study indicate that training effects were not limited by age.

In order to obtain the geometry and size of bone implants that match the patient's original bone from this study, the patient femur knee bone is reconstructed into a 3D femur implant model using an X-Ray data scanner during Reverse Engineering (RE) process. In the process of RE, the femur knee bone was initially reconstructed by scanning its front and side view into a photo using the digital radiography system. For building a 3D model of the femur implant, the front and side view of the knee bones are sketched according to the dimensions and shape of the scanned femur knee bones. Then, one of the sketches is defined as the sketch profile of the femur knee bone, while the other is the trajectory profile. 3D modeling of the femur implant was constructed by using the sweep method in 3D design software. The results of this knee reconstruction obtained a 3D model of the femoral knee bone implant that is following the patient's bone shape.

Background: The use of artificial bone analogs in biomechanical testing of orthopaedic fracture fixation devices has increased, particularly due to the recent development of commercially available femurs such as the third generation composite femur that closely reproduce the bulk mechanical behavior of human cadaveric and∕or fresh whole bone. The purpose of this investigation was to measure bone screw pullout forces in composite femurs and determine whether results are comparable to cadaver data from previous literature. Method of Approach: The pullout strengths of 3.5 and 4.5mm standard bicortical screws inserted into synthetic third generation composite femurs were measured and compared to existing adult human cadaveric and animal data from the literature. Results: For 3.5mm screws, the measured extraction shear stress in synthetic femurs (23.70-33.99MPa) was in the range of adult human femurs and tibias (24.4-38.8MPa). For 4.5mm screws, the measured values in synthetic femurs (26.04-34.76MPa) were also similar to adult human specimens (15.9-38.9MPa). Synthetic femur results for extraction stress showed no statistically significant site-to-site effect for 3.5 and 4.5mm screws, with one exception. Overall, the 4.5mm screws showed statistically higher stress required for extraction than 3.5mm screws. Conclusions: The third generation composite femurs provide a satisfactory biomechanical analog to human long-bones at the screw-bone interface. However, it is not known whether these femurs perform similarly to human bone during physiological screw “toggling.”

The aim of the present study was to evaluate the mechanical behaviour of the femur and humerus of Cerdocyon thous through three-point bending and axial compression tests. For this, 13 femurs and 15 humerus were used in the bending test, and 14 femurs and 15 humerus in the compression test; after the assays were completed, bone fragments were collected for evaluation by means of conventional optical and polarized light microscopy, and scanning electron microscopy. It was observed that the humerus is more resistant in relation to the femur in both tests, and that bone length and weight, in addition to the width of the diaphysis, are influential on the mechanical behaviour. Microscopic evaluation showed that, on the cranial surface of the fractured bones under flexion, the fracture was caused by the deflection mechanism, while the caudal surface was ruptured by delamination. In bones submitted to axial compression, diaphyseal fractures occurred by deflection, while physeal fractures were caused by several mechanisms. There was no significant correlation between the arrangement of collagen fibres or mineral content on the mechanical properties obtained in both assays. It can be concluded that there are significant differences in the mechanical behaviour of the femur and humerus of C. thous, where the humerus is more resistant than the femur in both flexion and compression loads. Such data allow us to predict the bone mechanical behaviour of C. thous in the face of trauma caused by flexion and compression impacts, such as those resulting from running over.

Objectives: Aluminum has may be cytotoxic to animals and humans. It is mainly stored in bone and unfortunately, its absorption is increased with age. This study is done to define possible aluminum pathological changes in bone of aging albino rats. Methods: Twenty male albino rats aged 24 months was divided into two groups, control experimental. Experimental group received aluminum chloride for 10 weeks orally. The femur of both control and experimental group is investigated by light and electron microscope. Plain X-ray to the femur as an example to bone is also done. Results: Plain X-ray of femurs of the experimental group showed medullary bone trabeculae destruction, cortical bone resorption and sclerosis. Sections of the shaft of the femur stained with H&E confirmed X-ray gross picture and the bony cortex appeared very thin in comparison with control and showed multiple erosion cavities that may leads to bone fractures. Bone cells appeared few and highly degenerated while the periosteum was very thin and detached from the bone cortex. The bone trabeculae were highly destroyed, and the wide bone marrow spaces were filled by fat cells in some bones. At the level of electron microscope, both osteocytes and osteoblasts revealed severe degenerative changes and showed few irregular collagenous matrices. Conclusion: The degenerative changes observed in the bone of this study are most probably due to aluminum ingestion.

To assess the performance of femoral orthopedic implants, they are often attached to cadaveric femurs, and biomechanical testing is performed. To identify areas of high stress, stress shielding, and to facilitate implant redesign, these tests are often accompanied by finite element (FE) models of the bone/implant system. However, cadaveric bone suffers from wide specimen to specimen variability both in terms of bone geometry and mechanical properties, making it virtually impossible for experimental results to be reproduced. An alternative approach is to utilize synthetic femurs of standardized geometry, having material behavior approximating that of human bone, but with very small specimen to specimen variability. This approach allows for repeatable experimental results and a standard geometry for use in accompanying FE models. While the synthetic bones appear to be of appropriate geometry to simulate bone mechanical behavior, it has not, however, been established what bone quality they most resemble, i.e., osteoporotic or osteopenic versus healthy bone. Furthermore, it is also of interest to determine whether FE models of synthetic bones, with appropriate adjustments in input material properties or geometric size, could be used to simulate the mechanical behavior of a wider range of bone quality and size. To shed light on these questions, the axial and torsional stiffness of cadaveric femurs were compared to those measured on synthetic femurs. A FE model, previously validated by the authors to represent the geometry of a synthetic femur, was then used with a range of input material properties and change in geometric size, to establish whether cadaveric results could be simulated. Axial and torsional stiffnesses and rigidities were measured for 25 human cadaveric femurs (simulating poor bone stock) and three synthetic “third generation composite” femurs (3GCF) (simulating normal healthy bone stock) in the midstance orientation. The measured results were compared, under identical loading conditions, to those predicted by a previously validated three-dimensional finite element model of the 3GCF at a variety of Young’s modulus values. A smaller FE model of the 3GCF was also created to examine the effects of a simple change in bone size. The 3GCF was found to be significantly stiffer (2.3 times in torsional loading, 1.7 times in axial loading) than the presently utilized cadaveric samples. Nevertheless, the FE model was able to successfully simulate both the behavior of the 3GCF, and a wide range of cadaveric bone data scatter by an appropriate adjustment of Young’s modulus or geometric size. The synthetic femur had a significantly higher stiffness than the cadaveric bone samples. The finite element model provided a good estimate of upper and lower bounds for the axial and torsional stiffness of human femurs because it was effective at reproducing the geometric properties of a femur. Cadaveric bone experiments can be used to calibrate FE models’ input material properties so that bones of varying quality can be simulated.

Thesis (M.S.)--West Virginia University, 2001.
Title from document title page. Document formatted into pages; contains vii, 78 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 63-69).

Often bone fractures are joined by inserting metal plates and screws to hold the fragmented bone under compression. However, after the fractured bone is healed removing the screws leaves holes in the bone which takes months to fill up and heal completely. The goal of this research is to investigate those voids specifically in a finite element model of a femur. The holes were found to experience high stress that can easily lead to crack propagations during everyday activities. Finite element models of femurs were modeled after two common fracture fixation systems, specifically just after the plates, rods and screws are removed. To observe the stress levels bones are likely to experience, common mechanical tests that are relevant to or associated with common daily activities were performed. While the 3-point bending tests did not yield significant results, the compression and torsion tests produced high stress areas near the screw holes. In certain cases, the von Mises’ stress reached 3.66 x 106 N/mm2. Our finite element modeling seeks to establish groundwork for future explorations on the holes created by fracture fixation hardware. In the future, this work will lead to redesigning of fixation systems with reduced stress concentration around the holes. Therefore, the initiation of new cracks around these holes will be limited during everyday activity.

Thesis (Ph. D.)--West Virginia University, 2001.
Title from document title page. Document formatted into pages; contains xv. 191 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 166-183).

This study compared bone mineral index (BMI, gm/cm²) of the femur, spine, and radius, measured by photon absorptiometry in various groups of eumenorrheic female athletes. The sample included body builders (11), swimmers (13), runners (5 collegiate, 11 recreational), and inactive controls (18) averaging 25 years of age, ranging from 17 to 38 years. Lumbar vertebral BMI for body builders (1.40 gm/cm²) was significantly (p ≤ 0.05) greater than controls (1.25 gm/cm²). The body builders' femoral neck BMI (1.09 gm/cm²) was significantly greater than swimmers (0.97 gm/cm², recreational runners and controls (0.95 gm/cm²). Years of exercise history and calcium consumption were not significant predictors of BMI. Correlation coefficients between fat-free body and all BMI sites were significant and more closely related to bone mineral than other variables (weight, height, weight/height²). Correlation coefficients for proximal and distal radius BMI and femoral and spine BMI were significant, the distal radius having higher association.

The purpose of this study was to develop injury risk functions for dynamic bending of the human femur in the lateral-to-medial and posterior-to-anterior loading directions. A total of 45 experiments were performed on human cadaver femurs using a dynamic three-point drop test setup. All 45 tests resulted in mid-shaft femur fractures with comminuted wedge and oblique fractures as the most common fracture patterns. The reaction loads were used to develop the injury criteria given that they represent the inertially compensated bending strength of the femur that is more appropriate for dummy load cell application. In the lateral-to-medial bending tests the peak reaction bending moments were 352 ± 83 Nm. In the posterior-to-anterior bending tests the peak reaction bending moments were 348 ± 96 Nm. Regression analysis was used to identify significant parameters, and parametric survival analysis was used to estimate risk functions. Femur cross-sectional area, area moment of inertia (I), maximum distance to the neutral axis (c), I/c, occupant gender, and occupant mass are shown to be significant predictors of fracture tolerance, while no significant difference is shown for loading direction, bone mineral density, leg aspect and age. Risk functions are presented for femur cross-sectional area, I/c, and a combined occupant gender and mass. The risk function that utilizes the most highly correlated (R2 = 0.77) and significant (p = 0.0001) variable, cross-sectional area, predicts a 50 percent risk of femur fracture of 240 Nm, 395 Nm, and 562 Nm for equivalent cross-sectional area of the 5th percentile female, 50th percentile male, and 95th percentile male respectively.
Master of Science

The study presented attempts to prove the concept that mechanical changes in the structure of a bone can be predicted for a specific exercise by a subject specific model created from CT data, MRI data, EMG data, and a physiologic FE model. Previous work generated a subject specific FE model of a femur via CT and MRI data as well as created a set of subject specific biomechanical muscle forces that are required to perform a single leg extension exercise. The FE model and muscle forces were implemented into a single leg extension FE code (ABAQUS) along with a specialized bone remodeling UMAT. The UMAT updated the mechanical properties of the femur via a damage-repair bone remodeling algorithm. The single leg extension FE code was verified by applying walking loads to the femur and allowing the system to equilibrate. The results were used to apply the appropriate walking loads to the final FE simulation for the single leg extension exercise. The final FE simulation included applying the single leg extension loads over a one year period and plotting the change in porosity at various regions of the femoral neck. Although only two regions were found to generate valid results, the data seemed counterintuitive to Wolff’s Law which states that bone adaptation is promoted when the material is stressed. The model was successful in creating a subject specific model that is capable of predicting changes in the mechanical properties of bone. However, in order to generate valid FE model results, further understanding of the bone remodeling process and application via a FE model is required.

The aim of this study is to investigate the deterioration in mechanical integrity of the collagen network in bovine bone with aging, which are related to fracture toughness. Age-related changes in collagen molecular structures formed by non-enzymatic glycation were examined and indentation fracture technique was used as a method for measuring the microstructural toughness of cortical bone. Microcrack propagation characteristics of bone for fragility were also studied. Young and old group of bovine cortical bone specimens were grouped into 2 as ribosylated and non-ribosylated which were rested in solutions for four weeks. Series of indentations were made on bone specimen groups for each of five masses 10g, 25g, 50g, 100g and 200g for 10 sec to detect the effect of applied indentation load. The applied load was increased to 300g, 500g, 1000g and 2000g for 10 sec to be able to make microcracks. Series of indentations were made on bone specimen groups for each of five durations 5sec, 10sec, 20sec, 30sec for 100g to study the effect of indentation duration. Specimens were examined in the wet and dry state while studying the factors effecting microhardness measurement. Microhardness values measured by 10g of load for 10sec were indifferent between the ribosylated and non-ribosylated groups in the young and old bovine bone pointing that this load is not indicative of the structural collagen changes. Loads of 25g, 50g, 100g and 200g for 10 sec were able to differ ribosylated bone from non-ribosylated bone for the young and old bovine bones. Degree of microhardness increased with increased incubation period. Microhardness of dry specimens being either ribosylated or non-ribosylated were found to be statistically higher than wet specimens in young and old bone except for 10g for 10sec. It has been shown that the calculated fracture toughness measured by the indentation method is a function of indentation load. Additionally, effect of indentation size might have resulted in a higher toughness measurement for higher indent loads with longer cracks even if the toughness is not actually higher.Methods using indentation technique has difficulty in relating the resistance to crack growth to the Mode I fracture toughness definition.Indentation fracture toughness allows sampling only one point on the R­
curve methods and was not considered as successful for assessing materials with rising R­
curve. Toughness is ranked incorrectly among riboslated and non-ribosylated bovine bone by this technique. Presence of extrinsic toughening mechanisms including crack bridging due to uncracked ligaments and collagen fibers were directly observed by scanning electron microscope. Ribosylated bone was found to have lower number of collagen bridging compared ton on-ribosylated bovine bone.As a summary, indentation fracture method by Vickers indentation in bone is a method for measuring the fracture toughness.

Bones are multifunctional passive organs of movement that supports soft tissue and directly attached muscles. They also protect internal organs and are a reserve of calcium, phosphorus and magnesium. Each bone is covered with periosteum, and the adjacent bone surfaces are covered by articular cartilage. Histologically, the bone is an organ composed of many different tissues. The main component is bone tissue (cortical and spongy) composed of a set of bone cells and intercellular substance (mineral and organic), it also contains fat, hematopoietic (bone marrow) and cartilaginous tissue. Bones are a tissue that even in adult life retains the ability to change shape and structure depending on changes in their mechanical and hormonal environment, as well as self-renewal and repair capabilities. This process is called bone turnover. The basic processes of bone turnover are: • bone modeling (incessantly changes in bone shape during individual growth) following resorption and tissue formation at various locations (e.g. bone marrow formation) to increase mass and skeletal morphology. This process occurs in the bones of growing individuals and stops after reaching puberty • bone remodeling (processes involve in maintaining bone tissue by resorbing and replacing old bone tissue with new tissue in the same place, e.g. repairing micro fractures). It is a process involving the removal and internal remodeling of existing bone and is responsible for maintaining tissue mass and architecture of mature bones. Bone turnover is regulated by two types of transformation: • osteoclastogenesis, i.e. formation of cells responsible for bone resorption • osteoblastogenesis, i.e. formation of cells responsible for bone formation (bone matrix synthesis and mineralization) Bone maturity can be defined as the completion of basic structural development and mineralization leading to maximum mass and optimal mechanical strength. The highest rate of increase in pig bone mass is observed in the first twelve weeks after birth. This period of growth is considered crucial for optimizing the growth of the skeleton of pigs, because the degree of bone mineralization in later life stages (adulthood) depends largely on the amount of bone minerals accumulated in the early stages of their growth. The development of the technique allows to determine the condition of the skeletal system (or individual bones) in living animals by methods used in human medicine, or after their slaughter. For in vivo determination of bone properties, Abstract 10 double energy X-ray absorptiometry or computed tomography scanning techniques are used. Both methods allow the quantification of mineral content and bone mineral density. The most important property from a practical point of view is the bone’s bending strength, which is directly determined by the maximum bending force. The most important factors affecting bone strength are: • age (growth period), • gender and the associated hormonal balance, • genotype and modification of genes responsible for bone growth • chemical composition of the body (protein and fat content, and the proportion between these components), • physical activity and related bone load, • nutritional factors: – protein intake influencing synthesis of organic matrix of bone, – content of minerals in the feed (CA, P, Zn, Ca/P, Mg, Mn, Na, Cl, K, Cu ratio) influencing synthesis of the inorganic matrix of bone, – mineral/protein ratio in the diet (Ca/protein, P/protein, Zn/protein) – feed energy concentration, – energy source (content of saturated fatty acids - SFA, content of polyun saturated fatty acids - PUFA, in particular ALA, EPA, DPA, DHA), – feed additives, in particular: enzymes (e.g. phytase releasing of minerals bounded in phytin complexes), probiotics and prebiotics (e.g. inulin improving the function of the digestive tract by increasing absorption of nutrients), – vitamin content that regulate metabolism and biochemical changes occurring in bone tissue (e.g. vitamin D3, B6, C and K). This study was based on the results of research experiments from available literature, and studies on growing pigs carried out at the Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences. The tests were performed in total on 300 pigs of Duroc, Pietrain, Puławska breeds, line 990 and hybrids (Great White × Duroc, Great White × Landrace), PIC pigs, slaughtered at different body weight during the growth period from 15 to 130 kg. Bones for biomechanical tests were collected after slaughter from each pig. Their length, mass and volume were determined. Based on these measurements, the specific weight (density, g/cm3) was calculated. Then each bone was cut in the middle of the shaft and the outer and inner diameters were measured both horizontally and vertically. Based on these measurements, the following indicators were calculated: • cortical thickness, • cortical surface, • cortical index. Abstract 11 Bone strength was tested by a three-point bending test. The obtained data enabled the determination of: • bending force (the magnitude of the maximum force at which disintegration and disruption of bone structure occurs), • strength (the amount of maximum force needed to break/crack of bone), • stiffness (quotient of the force acting on the bone and the amount of displacement occurring under the influence of this force). Investigation of changes in physical and biomechanical features of bones during growth was performed on pigs of the synthetic 990 line growing from 15 to 130 kg body weight. The animals were slaughtered successively at a body weight of 15, 30, 40, 50, 70, 90, 110 and 130 kg. After slaughter, the following bones were separated from the right half-carcass: humerus, 3rd and 4th metatarsal bone, femur, tibia and fibula as well as 3rd and 4th metatarsal bone. The features of bones were determined using methods described in the methodology. Describing bone growth with the Gompertz equation, it was found that the earliest slowdown of bone growth curve was observed for metacarpal and metatarsal bones. This means that these bones matured the most quickly. The established data also indicate that the rib is the slowest maturing bone. The femur, humerus, tibia and fibula were between the values of these features for the metatarsal, metacarpal and rib bones. The rate of increase in bone mass and length differed significantly between the examined bones, but in all cases it was lower (coefficient b <1) than the growth rate of the whole body of the animal. The fastest growth rate was estimated for the rib mass (coefficient b = 0.93). Among the long bones, the humerus (coefficient b = 0.81) was characterized by the fastest rate of weight gain, however femur the smallest (coefficient b = 0.71). The lowest rate of bone mass increase was observed in the foot bones, with the metacarpal bones having a slightly higher value of coefficient b than the metatarsal bones (0.67 vs 0.62). The third bone had a lower growth rate than the fourth bone, regardless of whether they were metatarsal or metacarpal. The value of the bending force increased as the animals grew. Regardless of the growth point tested, the highest values were observed for the humerus, tibia and femur, smaller for the metatarsal and metacarpal bone, and the lowest for the fibula and rib. The rate of change in the value of this indicator increased at a similar rate as the body weight changes of the animals in the case of the fibula and the fourth metacarpal bone (b value = 0.98), and more slowly in the case of the metatarsal bone, the third metacarpal bone, and the tibia bone (values of the b ratio 0.81–0.85), and the slowest femur, humerus and rib (value of b = 0.60–0.66). Bone stiffness increased as animals grew. Regardless of the growth point tested, the highest values were observed for the humerus, tibia and femur, smaller for the metatarsal and metacarpal bone, and the lowest for the fibula and rib. Abstract 12 The rate of change in the value of this indicator changed at a faster rate than the increase in weight of pigs in the case of metacarpal and metatarsal bones (coefficient b = 1.01–1.22), slightly slower in the case of fibula (coefficient b = 0.92), definitely slower in the case of the tibia (b = 0.73), ribs (b = 0.66), femur (b = 0.59) and humerus (b = 0.50). Bone strength increased as animals grew. Regardless of the growth point tested, bone strength was as follows femur > tibia > humerus > 4 metacarpal> 3 metacarpal> 3 metatarsal > 4 metatarsal > rib> fibula. The rate of increase in strength of all examined bones was greater than the rate of weight gain of pigs (value of the coefficient b = 2.04–3.26). As the animals grew, the bone density increased. However, the growth rate of this indicator for the majority of bones was slower than the rate of weight gain (the value of the coefficient b ranged from 0.37 – humerus to 0.84 – fibula). The exception was the rib, whose density increased at a similar pace increasing the body weight of animals (value of the coefficient b = 0.97). The study on the influence of the breed and the feeding intensity on bone characteristics (physical and biomechanical) was performed on pigs of the breeds Duroc, Pietrain, and synthetic 990 during a growth period of 15 to 70 kg body weight. Animals were fed ad libitum or dosed system. After slaughter at a body weight of 70 kg, three bones were taken from the right half-carcass: femur, three metatarsal, and three metacarpal and subjected to the determinations described in the methodology. The weight of bones of animals fed aa libitum was significantly lower than in pigs fed restrictively All bones of Duroc breed were significantly heavier and longer than Pietrain and 990 pig bones. The average values of bending force for the examined bones took the following order: III metatarsal bone (63.5 kg) <III metacarpal bone (77.9 kg) <femur (271.5 kg). The feeding system and breed of pigs had no significant effect on the value of this indicator. The average values of the bones strength took the following order: III metatarsal bone (92.6 kg) <III metacarpal (107.2 kg) <femur (353.1 kg). Feeding intensity and breed of animals had no significant effect on the value of this feature of the bones tested. The average bone density took the following order: femur (1.23 g/cm3) <III metatarsal bone (1.26 g/cm3) <III metacarpal bone (1.34 g / cm3). The density of bones of animals fed aa libitum was higher (P<0.01) than in animals fed with a dosing system. The density of examined bones within the breeds took the following order: Pietrain race> line 990> Duroc race. The differences between the “extreme” breeds were: 7.2% (III metatarsal bone), 8.3% (III metacarpal bone), 8.4% (femur). Abstract 13 The average bone stiffness took the following order: III metatarsal bone (35.1 kg/mm) <III metacarpus (41.5 kg/mm) <femur (60.5 kg/mm). This indicator did not differ between the groups of pigs fed at different intensity, except for the metacarpal bone, which was more stiffer in pigs fed aa libitum (P<0.05). The femur of animals fed ad libitum showed a tendency (P<0.09) to be more stiffer and a force of 4.5 kg required for its displacement by 1 mm. Breed differences in stiffness were found for the femur (P <0.05) and III metacarpal bone (P <0.05). For femur, the highest value of this indicator was found in Pietrain pigs (64.5 kg/mm), lower in pigs of 990 line (61.6 kg/mm) and the lowest in Duroc pigs (55.3 kg/mm). In turn, the 3rd metacarpal bone of Duroc and Pietrain pigs had similar stiffness (39.0 and 40.0 kg/mm respectively) and was smaller than that of line 990 pigs (45.4 kg/mm). The thickness of the cortical bone layer took the following order: III metatarsal bone (2.25 mm) <III metacarpal bone (2.41 mm) <femur (5.12 mm). The feeding system did not affect this indicator. Breed differences (P <0.05) for this trait were found only for the femur bone: Duroc (5.42 mm)> line 990 (5.13 mm)> Pietrain (4.81 mm). The cross sectional area of the examined bones was arranged in the following order: III metatarsal bone (84 mm2) <III metacarpal bone (90 mm2) <femur (286 mm2). The feeding system had no effect on the value of this bone trait, with the exception of the femur, which in animals fed the dosing system was 4.7% higher (P<0.05) than in pigs fed ad libitum. Breed differences (P<0.01) in the coross sectional area were found only in femur and III metatarsal bone. The value of this indicator was the highest in Duroc pigs, lower in 990 animals and the lowest in Pietrain pigs. The cortical index of individual bones was in the following order: III metatarsal bone (31.86) <III metacarpal bone (33.86) <femur (44.75). However, its value did not significantly depend on the intensity of feeding or the breed of pigs.

Bone 470Skeletal muscle 472Classification of fractures 474Treatment of fractures 476Management of a child with a fractured femur 478Fractured tibia and fibula 480Supracondylar fracture of humerus 482Fractured radius and ulna 484Fractures of metacarpals and metatarsals 486External fixation ...

This chapter begins by discussing the basic principles of musculoskeletal physiology, fracture assessment, and fracture management, before focusing on the key areas of knowledge, namely congenital and developmental conditions, the foot, the ankle, the knee, the femoral and tibial shaft, the proximal femur, the pelvis, the shoulder, the upper limb, degenerative and inflammatory arthritis, bone and joint infection, crystal arthropathies, musculoskeletal tumours, and metabolic bone conditions. The chapter concludes with relevant case-based discussions.

Femur bone is the longest and largest bone in the human skeleton. This bone connects the pelvic bone to the knee and carries most of the body weight. The static behavior of femur bone has been a center of investigation for many years while little attention has been given to its dynamic and vibrational behavior, which is of great importance in sports activities, car crashes and elderly falls. Investigation of natural frequencies and mode shapes of bone structures are important to understand the dynamic and vibrating behaviors. Vibrational analysis of femoral bones is presented using finite element method. In the analysis, the bone was modeled with isotropic and orthotropic mechanical properties. The effect of surrounding bone muscles has also been accounted for as a viscoelastic medium embedding the femur bone. Natural frequencies extracted considering the effects of age aggravated by weakening the elastic modulus and density loss. The effects of real complex bone geometry on natural frequencies are studied and are compared with a simple circular cross-sectional model.

The article presents research on the study of the osteotropic effect of the drug siliostin by assessing the linear and structural parameters of the femur bone. A comparative analysis of such indicators as the mass and length of the femur bone, as well as the width at the site of the anatomical localization of the epiphyses and diaphyses was carried out. A macroscopic evaluation and comparison of the compact layer of bone tissue on segmental cuts was performed. It has been determined that the introduction of siliostin into the diet of broiler chickens has a pronounced osteotropic effect, as evidenced by the obtained results such as an increase in the mass of the femur bones in the experimental group by 15.3-17.0%, the width of the epiphyses and diaphyses of the femur bones by 3, 3–10.2%, thickening of the compact layer of the femur bones in 1.86 times

Aim/Purpose: The aim of the study was to analyze the structure of the bone tissue by using texture analysis of the bone trabeculae, as visualized in a routine radiograph of the proximal femur . This could provide objective information regarding both the mineral content and the spatial structure of bone tissue. Therefore, machine-learning tools were applied to explore the use of texture analysis for obtaining information on the bone strength. Background: One in three women in the world develops osteoporosis, which weakens the bones, causes atraumatic fractures and lowers the quality of life. The damage to the bones can be minimized by early diagnosis of the disease and preventive treatment, including appropriate nutrition, bone-building exercise and medications. Osteoporosis is currently diagnosed primarily by DEXA (Dual Energy X-ray Absorptiometry), which measures the bone mineral density alone. However, bone strength is determined not only by its mineral density but also by the spatial structure of bone trabeculae. In order to obtain valuable information regarding the bone strength, the mineral content and the spatial structure of the bone tissue should be objectively assessed. Methodology: The study includes 17 radiographs of in-vitro femurs without soft tissue and 44 routine proximal femur radiographs (15 subjects with osteoporotic fractures and 29 without a fracture). The critical force required to fracture the in-vitro femurs was measured and the bones were divided into two groups: 11 solid bones with critical fracture force higher than 4.9kN and 6 fragile bones with critical fracture force lower than 4.9kN. All the radiographs included an aluminum step-wedge for calibrating the gray-levels values (See Figure 3). An algorithm was developed to automatically adjust the gray levels in order to yield equal brightness and contrast. Findings: The algorithm characterized the in-vitro bones with as fragile or solid with an accuracy of 88%. For the radiographs of the patients, the algorithm characterized the bones as osteoporotic or non-osteoporotic with an accuracy of 86%. The most prominent features for estimating the bone strength were the mean gray-level, which is related to bone density, and the smoothness, uniformity and entropy, which are related to the spatial distribution of the bone trabeculae. Impact on Society: Analysis of bone tissue structure, using machine-learning tools will provide a significant information on the bone strength, for the early diagnosis of osteoporosis. The structure analysis can be performed on routine radiographs of the proximal femur, with high accuracy. Future Research: The algorithm for automatic structure analysis of bone tissue as visualized on a routine femoral radiograph should be further trained on a larger dataset of routine radiographs in order to improve the accuracy of assessing the bone strength.

Osteoporosis and degenerative diseases cause low bone mass that increases fracture risks. This study presents the modelling of osteoporotic femur by employing finite element method (FEM). The loading of femur using FEM tools was performed. The level of degradation was modelled by changing the thickness of cortical shell and using power-law equations, which determine the dependence between apparent density of cancellous bone and its mechanical properties. Obtained results could be useful for both medical diagnosis and bone health check.

Despite the central role of femoral strength in the etiology of osteoporotic hip fractures [1], the associated micromechanical basis of femoral strength remains poorly understood. Cadaver studies [2] using biomechanical testing have established that both the cortical and trabecular bone contribute to the structural integrity of the proximal femur but these studies did not address mechanisms. Addressing mechanisms, theoretical and finite element continuum analyses have assessed cortical-trabecular load sharing and have described stress and strain distributions throughout the proximal femur [1,3]. However, the regions of the bone at highest risk of initial failure remain unclear, in part because the continuum nature and low spatial resolution of these previous analyses render them incapbable of capturing load transfer associated with the microstructure of the trabecular bone and the sometimes thin cortex. Overcoming this limitation, micro-CT-based finite element analysis has recently been applied to the entire proximal femur [4], but so far only two femurs have been analyzed and thus reported trends are difficult to generalize. To extend this recent work and provide further insight into the microstructural basis of femoral strength, we applied micro-CT based finite element analysis to investigate femoral micro-mechanics in a cohort of elderly human proximal femurs.

The neck portion of the human femur is the most vulnerable region to attract stress-induced fractures. The loads of the human body act on the hip joint and on the greater trochanter region through abductor muscles. The bone is a natural composite and a good example of functionally graded material (FGM). This study considers a probabilistic finite element approach to assess the critical stresses in the femur under static loads. Material properties assigned to the bone model are linearly elastic, isotropic and orthotropic. Material characterization in terms of bone density is established by Computed Tomography (CT) data. The strength reliability and safety margin are obtained using relevant limit state function. Sensitivity analysis with respect to random parameters provides basis for a possible implant material characterization.

In this study, a model of femur which resembles bone natural structure has been developed. The model initially consists of a solid shell representing cortical bone encompassing a cubical network of interconnected rods with circular cross-sections representing trabecular bone part. A computational efficient program has been developed which iteratively changes the structure of trabecular bone by keeping the local stress in the structure within a defined stress range. The stress is controlled by either enhancing existing beam elements or removing beams from the initial trabecular frame structure. Trabecular bone structure is obtained for two load cases: walking and stair climbing. The results show that as the magnitude of the loads increase, the internal structure gets denser in critical zones. The higher density is achieved using loading associated with the stair climbing. Walking which is considered as the routine daily activity, results in the less internal density in different regions of the bone. The results show that the converged bone architecture consisting of rods and plates are consistent with the natural bone morphology of femur. Furthermore, the bone volume fraction at the critical regions of the converged structure is in a good agreement with previously measured data obtained from combinations of Dual X-ray Absorptiometry (DXA) and Computed Tomography (CT).