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Zeitschriftenartikel zum Thema „GdpP“

Autor: Grafiati

Veröffentlicht am 30. Juni 2021

Zuletzt aktualisiert am 29. Juli 2025

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Brito, Vinicius Nahime, Berenice Bilharinho Mendonca, Laura M. F. F. Guilhoto, Karina Cocco Monteiro Freitas, Ivo J. Prado Arnhold та Ana Claudia Latronico. "Allelic Variants of the γ-Aminobutyric Acid-A Receptor α1-Subunit Gene (GABRA1) Are Not Associated with Idiopathic Gonadotropin-Dependent Precocious Puberty in Girls with and without Electroencephalographic Abnormalities". Journal of Clinical Endocrinology & Metabolism 91, № 6 (2006): 2432–36. http://dx.doi.org/10.1210/jc.2005-2657.

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Abstract Context: γ-Aminobutyric acid (GABA) is a dominant inhibitory neurotransmitter involved in the modulation of brain electric activity and puberty onset in primates. GABA inhibitory effects on GnRH neurons are mainly mediated by GABA-A receptor α1-subunit. Objective: The objective of this study was to investigate functional mutations or polymorphisms of the GABA-A receptor α1-subunit gene (GABRA1) in girls with idiopathic gonadotropin-dependent precocious puberty (GDPP) with and without electroencephalographic (EEG) abnormalities. Design: The entire coding region of GABRA1 was sequenced

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Halawani, Hanan, Halima Mohamed, Sarah Alzakari, et al. "Attention recurrent neural network with earthworm optimization on gross domestic product prediction using main economic activities." Thermal Science 28, no. 6 Part B (2024): 5087–95. https://doi.org/10.2298/tsci2406087h.

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Gross domestic product (GDP) is a vital metric for evaluating the financial strength and development of a nation. It extends the complete value of services and goods produced within an exact time, presenting critical perceptions into the complete financial performance and health. This study focuses on enhancing GDP prediction by examining key economic activities such as non-oil, oil, and government sectors. Understanding these modules is important for accurately predicting economic trials, which impact tax revenue, living standards, and economic stability. By incorporating these foremost finan

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Wang, Feng, Qing He, Kaixuan Su, Tiandi Wei, Sujuan Xu, and Lichuan Gu. "Structural and biochemical characterization of the catalytic domains of GdpP reveals a unified hydrolysis mechanism for the DHH/DHHA1 phosphodiesterase." Biochemical Journal 475, no. 1 (2018): 191–205. http://dx.doi.org/10.1042/bcj20170739.

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The Asp-His-His and Asp-His-His-associated (DHH/DHHA1) domain-containing phosphodiesterases (PDEs) that catalyze degradation of cyclic di-adenosine monophosphate (c-di-AMP) could be subdivided into two subfamilies based on the final product [5′-phosphadenylyl-adenosine (5′-pApA) or AMP]. In a previous study, we revealed that Rv2837c, a stand-alone DHH/DHHA1 PDE, employs a 5′-pApA internal flipping mechanism to produce AMPs. However, why the membrane-bound DHH/DHHA1 PDE can only degrade c-di-AMP to 5′-pApA remains obscure. Here, we report the crystal structure of the DHH/DHHA1 domain of GdpP (G

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Yava Rony, Devi, Prih Sarnianto, and Yusi Anggriani. "Pengaruh Asuhan Kefarmasian Terhadap Kualitas Hidup Pasien Diabetes Melitus Tipe 2 di Puskesmas Kabupaten Cirebon." Syntax Literate ; Jurnal Ilmiah Indonesia 5, no. 6 (2020): 64. http://dx.doi.org/10.36418/syntax-literate.v5i6.1324.

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Asuhan kefarmasian pada pasien Diabetes Melitus tipe 2 diharapkan dapat meningkatkan kepatuhan minum obat sehingga glukosa darah terkendali dan kualitas hidup optimal. Penelitian ini dilakukan untuk mengetahui pengaruh asuhan kefarmasian dalam meningkatkan kepatuhan minum obat, pengendalian kadar glukosa darah dan kualitas hidup pasien DM tipe 2. Penelitian bersifat prospektif menggunakan desain kuasi eksperimental komparatif (control group design withpre-test-post-test). Sebanyak 80 pasien terdiri dari 40 pasien non-Prolanis Puskesmas Talun (intervensi, diberi asuhan kefarmasian) dengan total

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Sopova, Yu V., M. E. Velizhanina, D. А. Кandina, et al. "The Influence of Deletion in the Non-Catalytic Domain of GdpP Mediated by Genome Editing with CRISPR/Cas9 on the Phenotype of <i>Staphylococcus aureus</i>." Генетика 59, no. 9 (2023): 1094–98. http://dx.doi.org/10.31857/s0016675823090126.

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The high cellular level of cyclic di-adenosine monophosphate (c-di-AMP), which in turn results in resistance to cell-wall targeted antibiotics in Staphylococcus aureus. An increase in intracellular molecules of c-di-AMP is due to mutations in the DHH/DHHA1 domain of the GdpP protein. The influence of mutations in the other domains of GdpP has not been fully studied. The aim of this study was to obtain a targeted non-frameshifting deletion in the GdpP protein’s linker region between the GGDEF and DHH/DHHA1 domains. Restriction-modification deficient strain S. aureus RN4220 was used for genome e

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Khan, Kaynat, Ahmad Alam, and Hamid Ashraf. "Hypothalamic hamartoma in an infant presenting as precocious puberty." IJEM Case Reports 2, no. 1 (2024): 32–36. http://dx.doi.org/10.4103/ijemcr.ijemcr_14_24.

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ABSTRACT Precocious puberty refers to the emergence of secondary sexual traits before the typical age for children of the same gender and race. It is classified into gonadotropin-dependent precocious puberty (GDPP) and gonadotropin-independent precocious puberty (GIPP) based on the underlying pathologic process. GDPP is caused by premature activation of the hypothalamic–pituitary–gonadal axis, while GIPP results from excessive sex hormone synthesis from the gonads or adrenal glands. This report presents a case of GDPP in a female toddler. The patient exhibited symptoms of precocious puberty as

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Rosdaniati, Rosdaniati, Yusi Anggriani, Hesty Utami R, and Tri Kusumaeni. "Evaluasi Profil Pengobatan dan Outcome Klinis Penggunaan Insulin Analog pada Pasien BPJS DM Tipe 2 Di RSUP Persahabatan Jakarta." Syntax Literate ; Jurnal Ilmiah Indonesia 5, no. 8 (2020): 663. http://dx.doi.org/10.36418/syntax-literate.v5i8.1554.

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Insulin digunakan untuk menurunkan glukosa darah dan kadar HbA1C serta dapat mengurangi komplikasi mikrovaskular. Tujuan penelitian ini adalah untuk mengetahui profil pengobatan, faktor-faktor yang mempengaruhi dalam pemilihan terapi insulin dan untuk mengetahui perbedaan outcome klinis pasien diabetes melitus tipe 2 yang menggunakan insulin di RSUP Persahabatan. Penelitian ini merupakan penelitian retrospektif, yang dilakukan secara longitudinal time series. Populasi adalah pasien BPJS DM tipe 2 RSUP Persahabatan periode Januari 2017-Desember 2018 sejumlah 1.100 pasien. Sampel sebanyak 285 di

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Yuliasari, Ida, Yusi Anggriani, and Hesty Utami R. "Outcome Klinik Berdasarkan Pemilihan Jenis Insulin pada Pasien Diabetes Mellitus Tipe 2." Farmasains : Jurnal Ilmiah Ilmu Kefarmasian 9, no. 2 (2022): 87–95. http://dx.doi.org/10.22236/farmasains.v9i2.6931.

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Diabetes Mellitus ( DM ) merupakan penyakit tidak menular yang meningkat prevalensinya setiap tahun di Indonesia. Salah satu tatalaksana terapi DM adalah terapi farmakologi menggunakan insulin. Insulin yang beredar di Indonesia terdiri dari insulin manusia dan insulin analog. Tujuan dari penelitian ini adalah untuk mengetahui pola penggunaan insulin dan outcome klinik berdasarkan pola penggunaan insulin pada pasien rawat jalan dengan diagnosa DM tipe 2. Penelitian dilakukan secara longitudinal time series melalui pengambilan data retrospektif di Rekam Medis dan Farmasi yang meliputi data pasie

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Laxmi, Dewi, Shirly Kumala, Prih Sarnianto, and Asnah Tarigan. "Pengaruh Edukasi Farmasis terhadap Hasil Terapi dan Kualitas Hidup Pasien Prolanis Diabetes Melitus Tipe 2." Syntax Literate ; Jurnal Ilmiah Indonesia 6, no. 1 (2021): 154. http://dx.doi.org/10.36418/syntax-literate.v6i1.2086.

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Diabetes Mellitus merupakan suatu penyakit atau gangguan metabolisme kronis dengan multi etiologi yang ditandai dengan tingginya kadar glukosa darah disertai dengan gangguan metabolisme karbohidrat, protein, dan lipid sebagai akibat insufiensi fungsi insulin. Penyakit DM memerlukan pengelolaan secara benar, terpadu, dan berkesinambungan sehingga glukosa darah dapat terkontrol dan kualitas hidup yang optimal akan tercapai. Tujuan penelitian ini adalah dengan adanya konseling farmasis dapat meningkatkan pengetahuan dan kepatuhan pasien diabetes melitus tipe 2 sehingga tercapai hasil terapi kuali

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Brito, Vinicius Nahime, Ana Claudia Latronico, Ivo J. P. Arnhold, and Berenice Bilharinho Mendonça. "Update on the etiology, diagnosis and therapeutic management of sexual precocity." Arquivos Brasileiros de Endocrinologia & Metabologia 52, no. 1 (2008): 18–31. http://dx.doi.org/10.1590/s0004-27302008000100005.

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Precocious puberty is defined as the development of secondary sexual characteristics before the age of 8 years in girls and 9 years in boys. Gonadotropin-dependent precocious puberty (GDPP) results from the premature activation of the hypothalamic-pituitary-gonadal axis and mimics the physiological pubertal development, although at an inadequate chronological age. Hormonal evaluation, mainly through basal and GnRH-stimulated LH levels shows activation of the gonadotropic axis. Gonadotropin-independent precocious puberty (GIPP) is the result of the secretion of sex steroids, independently from

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Durand, Geraldine, Celine Dupieux-Chabert, Claude-Alexandre Gustave, et al. "608. Emerging Methicillin Resistance Mechanism in mec Gene-Negative Staphylococci not Detected by Reference Methods." Open Forum Infectious Diseases 6, Supplement_2 (2019): S284. http://dx.doi.org/10.1093/ofid/ofz360.677.

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Abstract Background B-lactam resistance in Staphylococci is mediated by mec genes usually diagnosed by disc diffusion Cefoxitin test (DDFOX) and PCR testing. Here, we report methicillin-resistant Staphylococcus lugdunensis and Staphylococcus aureus strains lacking mec gene misdiagnosed by reference methods. Since the strains are not B-lactamase hyperproducers we investigated the molecular basis of the methicillin resistance. Methods We tested 2 S. lugdunensis isolates (SL1, SL2) collected from distinct blood cultures of the same patient and 2 S. aureus isolates (SA1, SA2): (i) by DDFOX, (ii) f

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Holland, Linda M., Sinéad T. O'Donnell, Dmitri A. Ryjenkov, et al. "A Staphylococcal GGDEF Domain Protein Regulates Biofilm Formation Independently of Cyclic Dimeric GMP." Journal of Bacteriology 190, no. 15 (2008): 5178–89. http://dx.doi.org/10.1128/jb.00375-08.

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ABSTRACT Cyclic dimeric GMP (c-di-GMP) is an important biofilm regulator that allosterically activates enzymes of exopolysaccharide biosynthesis. Proteobacterial genomes usually encode multiple GGDEF domain-containing diguanylate cyclases responsible for c-di-GMP synthesis. In contrast, only one conserved GGDEF domain protein, GdpS (for GGDEF domain protein from Staphylococcus), and a second protein with a highly modified GGDEF domain, GdpP, are present in the sequenced staphylococcal genomes. Here, we investigated the role of GdpS in biofilm formation in Staphylococcus epidermidis. Inactivati

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Retnaningrum, Dyah, Yusi Anggriani, and Hesty Utami R. Tri Kusumaeni. "Evaluasi Outcome Klinis Penggunaan Insulin Analog dan Insulin Manusia pada Pasien DM Tipe 2 JKN Rawat Jalan Tahun 2015-2016 Di RSUD Tarakan." Syntax Literate ; Jurnal Ilmiah Indonesia 6, no. 3 (2021): 1149. http://dx.doi.org/10.36418/syntax-literate.v6i3.2375.

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Penelitian ini bertujuan mengetahui perbandingan profil pengobatan, outcome klinis dan biaya antara insulin analog dengan insulin manusia. Penelitian menggunakan metode longitudinal time series melalui pengumpulan data secara retrospektif menggunakan penelusuran rekam medis dan kuitansi biaya pengobatan. Sampel yang diambil adalah pasien DM tipe 2 JKN rawat jalan dengan terapi insulin periode Januari 2015-Desember 2016 di RSUD Tarakan yang memenuhi kriteria inklusi sebanyak 156 orang. Hasil analisis diperoleh penggunaan terbanyak adalah insulin Analog tunggal (98,19%). Proporsi obat non DM (56

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Noureen, Tyiba, Muhammad Zahid Malik, Nisar Ahmed Khuhro, and Muhammad Ali Zafar. "Exploring the Dynamics of CO2 Emissions, FDI, and Technological Innovation on Economic Growth: Evidence from BRICS Nations by Using CS-ARDL." Pakistan Journal of Humanities and Social Sciences 12, no. 3 (2024): 2456–69. http://dx.doi.org/10.52131/pjhss.2024.v12i3.2448.

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This research paper aims to determine the relationship between CO2 emissions, FDI, TR, TI, GCF, and LFPR on GDPP in the BRICS region, and finding emphases on the period between 2000-2023. The study further examined the relationship between the dependent and independent variable in the long-run and in the short-run by using the CS-ARDL. The outcomes from CS-ARDL reveal that CO2 emissions, FDI, TI, and GCF affect GDPP significantly. CO2 is, undoubtedly, an adverse phenomenon to the environment but corresponds to the increased level of industrial production and temporary EG. While trade and labor

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Wang, Bing, and Tianchi Chen. "Social Progress beyond GDP: A Principal Component Analysis (PCA) of GDP and Twelve Alternative Indicators." Sustainability 14, no. 11 (2022): 6430. http://dx.doi.org/10.3390/su14116430.

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What social progress is and how to measure it are seemingly plain but essentially intri-cate questions that have not been clarified to date, which has led to various social problems and development failures. Designed after the Great Depression in the 1930s, Gross Domestic Product (GDP) has been, on the one hand, regarded as the greatest invention of the 20th century and is widely accepted as the primary indicator for social progress, but on the other hand, it has been criticized as knowing the price of everything but the value of nothing. The Beyond GDP Movement that has been active since the

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Naotunna, C. R., D. N. Siriwardana, B. C. Lakmini, M. Samarasinghe, and N. Atapattu. "A Matter of Time: Delayed Presentation and Rapid Progression from Gonadotropin-Independent to Gonadotropin-Dependent Precocious Puberty following Successful Treatment for a Leydig Cell Tumor." Case Reports in Pediatrics 2022 (January 6, 2022): 1–4. http://dx.doi.org/10.1155/2022/5306138.

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Leydig cell tumors, most often benign, are a rare cause of isosexual gonadotropin-independent precocious puberty in boys due to secretion of testosterone. Very rarely do these tumors produce estrogen, causing gynecomastia. Testicular sparing surgery is the mainstay of treatment currently although radical orchidectomy was the choice in the past. Following surgery, clinical signs improve along with a revision of biochemical changes. Occasionally, it has been reported few children are progressed to gonadotropin-dependent precocious puberty (GDPP) after initial clinical and biochemical recovery. G

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Argudín, M. Angeles, S. Roisin, L. Nienhaus, et al. "Genetic Diversity amongStaphylococcus aureusIsolates Showing Oxacillin and/or Cefoxitin Resistance Not Linked to the Presence ofmecGenes." Antimicrobial Agents and Chemotherapy 62, no. 7 (2018): e00091-18. http://dx.doi.org/10.1128/aac.00091-18.

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ABSTRACTMethicillin-resistantStaphylococcus aureusisolates lackingmecgenes (n= 32), collected from Belgian hospitals, were characterized for their β-lactamase production and the presence of mutations inpbpgenes, thepbp4promoter, and genes involved in penicillin-binding protein 4 overproduction (gdpPandyjbH). Twelve isolates were β-lactamase hyperproducers (BHPs), while 12 non-BHP isolates might produce an incomplete GdpP protein. Most isolates showed nucleotide missense mutations inpbpgenes. A few isolates also showed mutations in thepbp4promoter.

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Asminaya, Nur Santy, Fuji Astuty Auza, Musram Abadi, et al. "PENGENALAN MANAJEMEN PEMELIHARAAN SAPI PERAH BERDASARKAN PEDOMAN GOOD DAIRY FARMING PRACTICE (GDFP) DI DESA WESALO, KABUPATEN KOLAKA TIMUR." BAKIRA: Jurnal Pengabdian Kepada Masyarakat 5, no. 1 (2024): 54–65. http://dx.doi.org/10.30598/bakira.2024.5.1.54-65.

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Dairy cows as milk-producing livestock will show their best performance if their maintenance management is carried out well. Good dairy cattle management can be done by referring to Good Dairy Farming Practice (GDFP). This service activity was carried out to increase the knowledge and skills of dairy farmers in Wesalo Village, Lalolae Village, East Kolaka Regency. The stages of this activity include: 1). activity preparation; 2. technical guidance on management of dairy cattle maintenance according to GDPP; 3. monitoring and evaluating activities. This activity is very beneficial for breeders

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Fang, Tian, Xiaoqian Zhang, Shanshan Hu, Yanyan Yu, Xue Sun, and Nianjun Xu. "Enzymatic Degradation of Gracilariopsis lemaneiformis Polysaccharide and the Antioxidant Activity of Its Degradation Products." Marine Drugs 19, no. 5 (2021): 270. http://dx.doi.org/10.3390/md19050270.

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Gracilariopsis lemaneiformis polysaccharides (GLP) were degraded using pectinase, glucoamylase, cellulase, xylanase, and β-dextranase into low-molecular-weight polysaccharides, namely, GPP, GGP, GCP, GXP, and GDP, respectively, and their antioxidant capacities were investigated. The degraded GLP showed higher antioxidant activities than natural GLP, and GDP exhibited the highest antioxidant activity. After the optimization of degradation conditions through single-factor and orthogonal optimization experiments, four polysaccharide fractions (GDP1, GDP2, GDP3, and GDP4) with high antioxidant abi

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Siringo, R., E. Suwardi, E. Haryono, and A. Kurniawan. "Analysing regional development in Indonesia based on GDP and cement consumption from 2010 to 2020." IOP Conference Series: Earth and Environmental Science 1190, no. 1 (2023): 012008. http://dx.doi.org/10.1088/1755-1315/1190/1/012008.

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Abstract This article analyses regional development in Indonesia from 2010-2020, based on its cement consumption. It investigates the relationship between cement demand, GDP, population, and urbanization by using Ordinary Least Square regression. In this period, Java known as the central cement producer and intake most of the product from the market. However, cement consumption per capita (CCP) in Kalimantan was the highest during 2010-2015 and in Sulawesi during 2016-2020. Meanwhile, high distribution cost has caused Eastern Indonesia consumed cement the least. The regression analysis shows t

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Kasap, Ahmet, and Mehmet Mert Türk. "Corruption Perception Index (CPI) and Macroeconomic Dynamics: Fragile Five Perspective." Yönetim ve Ekonomi Araştırmaları Dergisi 23, no. 1 (2025): 118–38. https://doi.org/10.11611/yead.1601414.

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This study examines the correlation between the corruption perception index (CPI) and economic and social indices in the Fragile Five nations (Brazil, India, Indonesia, Turkey, and South Africa) from 2012 to 2022. The study examines foreign direct investment (FDI), gross domestic product per capita (GDPP), human development index (HDI), income inequality (PALMA), and unemployment rate (UNEMP) as independent factors, with the Corruption Perception Index (CPI) serving as the dependent variable. The analysis, employing the least squares (LS) method and heteroskedasticity-robust standard errors, d

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Banerjee, Ritu, Michael Gretes, Christopher Harlem, Li Basuino та Henry F. Chambers. "A mecA-Negative Strain of Methicillin-Resistant Staphylococcusaureus with High-Level β-Lactam Resistance Contains Mutations in Three Genes". Antimicrobial Agents and Chemotherapy 54, № 11 (2010): 4900–4902. http://dx.doi.org/10.1128/aac.00594-10.

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ABSTRACT We previously generated a ceftobiprole-resistant S taphylococcus aureus strain after high inoculum serial passage of a mec A-negative variant of strain COL (R. Banerjee, M. Gretes, L. Basuino, N. Strynadka, and H. F. Chambers, Antimicrob. Agents Chemother. 52:2089-2096, 2008). Genome resequencing of this strain, CRB, revealed that it differs from its parent by five single-nucleotide polymorphisms in three genes, specifically, those encoding PBP4, a low-molecular-weight penicillin-binding protein, GdpP, a predicted signaling protein, and AcrB, a cation multidrug efflux transporter. CRB

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Cho, Kyu Hong, and Song Ok Kang. "Streptococcus pyogenes c-di-AMP Phosphodiesterase, GdpP, Influences SpeB Processing and Virulence." PLoS ONE 8, no. 7 (2013): e69425. http://dx.doi.org/10.1371/journal.pone.0069425.

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Ba, Xiaoliang, Lajos Kalmar, Nazreen F. Hadjirin та ін. "Truncation of GdpP mediates β-lactam resistance in clinical isolates of Staphylococcus aureus". Journal of Antimicrobial Chemotherapy 74, № 5 (2019): 1182–91. http://dx.doi.org/10.1093/jac/dkz013.

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Du, Bin, Wenhui Ji, Huiting An, et al. "Functional analysis of c-di-AMP phosphodiesterase, GdpP, in Streptococcus suis serotype 2." Microbiological Research 169, no. 9-10 (2014): 749–58. http://dx.doi.org/10.1016/j.micres.2014.01.002.

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Wang, Yanzhao, and Jianfei Cao. "Examining the Effects of Socioeconomic Development on Fine Particulate Matter (PM2.5) in China’s Cities Based on Spatial Autocorrelation Analysis and MGWR Model." International Journal of Environmental Research and Public Health 20, no. 4 (2023): 2814. http://dx.doi.org/10.3390/ijerph20042814.

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Understanding the characteristics of PM2.5 and its socioeconomic factors is crucial for managing air pollution. Research on the socioeconomic influences of PM2.5 has yielded several results. However, the spatial heterogeneity of the effect of various socioeconomic factors on PM2.5 at different scales has yet to be studied. This paper collated PM2.5 data for 359 cities in China from 2005 to 2020, as well as socioeconomic data: GDP per capita (GDPP), secondary industry proportion (SIP), number of industrial enterprise units above the scale (NOIE), general public budget revenue as a proportion of

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Mohd Nasir, Noormahayu Binti, Zarul Azhar Nasir, Norasyikin Abdullah Fahami, Muhammad Adidinizar Zia Ahmad Kusairee, and Khalijah Ramli. "Malaysia’s Healthcare Expenditure: ARDL Bound Test." ADVANCES IN BUSINESS RESEARCH INTERNATIONAL JOURNAL 7, no. 2 (2021): 267. http://dx.doi.org/10.24191/abrij.v7i2.13340.

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This study aims to analyse the relationships between income level, education expenditure, inflation, and ageing population towards health expenditure in Malaysia over the period of 1997 until 2017. This study employs Autoregressive Distributed-Lag (ARDL) Bound test in determining the long-run empirical relationships between all independent variables and healthcare expenditures in Malaysia. The findings show the existence of long run cointegration between healthcare expenditure inflation, income level, and the government’s education expenditure. The results confirmed that all independent variab

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Iramina, Aline. "GDPR v. GDPL." Law, State and Telecommunications Review 12, no. 2 (2020): 91–117. http://dx.doi.org/10.26512/lstr.v12i2.34692.

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Purpose ”“ The main purpose of this article is to analyze the aspects of the responsiveness approach adopted by European and Brazilian lawmakers in the elaboration of data protection rules, such as GDPR and LGPD.  Methodology ”“ The applied methodology is based on the responsive regulation theory and, additionally, the network governance theory, through the comparative analysis of personal data protection legal frameworks in Brazil and the EU. Findings ”“ Based on the comparative analysis of the GDPR and the LGPD, it is verified the adoption of escalated regulatory techniques of Ay

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Luo, Yun, та John D. Helmann. "A σD-dependent antisense transcript modulates expression of the cyclic-di-AMP hydrolase GdpP in Bacillus subtilis". Microbiology 158, № 11 (2012): 2732–41. http://dx.doi.org/10.1099/mic.0.062174-0.

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Griffiths, J. M., та A. J. O'Neill. "Loss of Function of the GdpP Protein Leads to Joint β-Lactam/Glycopeptide Tolerance in Staphylococcus aureus". Antimicrobial Agents and Chemotherapy 56, № 1 (2011): 579–81. http://dx.doi.org/10.1128/aac.05148-11.

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ABSTRACTThe genetic basis of tolerance to inhibitors of peptidoglycan biosynthesis inStaphylococcus aureuswas investigated by generating tolerant mutantsin vitroand characterizing them by comparative genome sequencing. Two independently selected tolerant mutants harbored nonsynonymous mutations ingdpP, a gene encoding a putative membrane-located signaling protein. Insertional inactivation ofgdpPalso conferred tolerance. Our findings further implicate altered signal transduction as a route to antibiotic tolerance inS. aureus.

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Permatasari, Rina, Yuke Andriane, Herry Garna, Oky Haribudiman, and R. A. Retno Ekowati. "Pengaruh Fraksi Air Buah Lemon (Citrus limon) terhadap Kadar Glukosa Darah Mencit Tua yang Diberi Pakan Tinggi Lemak." Jurnal Integrasi Kesehatan & Sains 1, no. 1 (2019): 54–58. http://dx.doi.org/10.29313/jiks.v1i1.4322.

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Diabetes melitus merupakan salah satu penyakit yang menjadi masalah terbesar pada abad 21. Obesitas (terutama obesitas viseral) dan resistensi insulin sering disertai dengan sekelompok kelainan yang disebut sindrom metabolik yang mencakup intoleransi glukosa, trigliserida tinggi, kolesterol HDL rendah, dan hipertensi. Lemon mengandung flavonoid yang dipercaya mempunyai aktivitas menurunkan kadar glukosa darah. Tujuan penelitian ini mengetahui perubahan kadar glukosa darah pada mencit tua yang diberi pakan tinggi lemak setelah pemberian fraksi air buah lemon (Citrus limon). Penelitian dilakukan

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Rachmah, Aulia Ilma, Dwi Prasetyani, and Bhimo Rizky Samudro. "Social Welfare Factors during Covid-19 in Indonesia in 2020-2021." Ekuilibrium : Jurnal Ilmiah Bidang Ilmu Ekonomi 18, no. 2 (2023): 179–89. http://dx.doi.org/10.24269/ekuilibrium.v18i2.2023.pp179-189.

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In general, the progress made by the state has the same goal of improving the welfare conditions of its citizens. An increase in the well-being of people in a region can be seen in the increase in wages received by that region. Unfortunately, at the end of 2019, in December to be exact, a catastrophe believed to be caused by an unknown pneumonia shook the world. The incident occurred in Wuhan, China. China recognized pneumonia as a separate novel coronavirus strain on January 7, 2020. The research method used is qualitative with panel data regression analysis using the 2020-2021 time series an

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Rohmawati, Riska, and Arif Helmi. "Penurunan Tingkat Kecemasan dan Gula Darah pada Penderita DM Tipe 2 melalui Spiritual Mindfulness Based On Benson Relaxation." Jurnal Keperawatan Jiwa 8, no. 2 (2020): 161. http://dx.doi.org/10.26714/jkj.8.2.2020.161-168.

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Perubahan mendadak dalam hidup membuat penderita DM menunjukkan beberapa reaksi psikologis negatif yang menghasilkan glukosa darah. Tujuan dari penelitian ini adalah untuk menjelaskan pengaruh mindfulness spiritual berdasarkan relaksasi benson pada kecemasan, gula darah pada pasien DM tipe 2. Penelitian ini menggunakan desain penelitian eksperimental quasy dengan pre-test dan post-test dengan desain kelompok kontrol dengan sampel 30 responden dan teknik pengambilan sampel menggunakan consecutive sampling. Intervensi dilakukan selama 4 minggu (15 menit untuk setiap intervensi). Penelitian ini m

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Smith, William M., Thi Huong Pham, Lin Lei, et al. "Heat Resistance and Salt Hypersensitivity in Lactococcus lactis Due to Spontaneous Mutation ofllmg_1816(gdpP) Induced by High-Temperature Growth." Applied and Environmental Microbiology 78, no. 21 (2012): 7753–59. http://dx.doi.org/10.1128/aem.02316-12.

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ABSTRACTDuring construction of several gene deletion mutants inLactococcus lactisMG1363 which involved a high-temperature (37.5°C) incubation step, additional spontaneous mutations were observed which resulted in stable heat resistance and in some cases salt-hypersensitive phenotypes. Whole-genome sequencing of one strain which was both heat resistant and salt hypersensitive, followed by PCR and sequencing of four other mutants which shared these phenotypes, revealed independent mutations inllmg_1816in all cases. This gene encodes a membrane-bound stress signaling protein of the GdpP family, m

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Gostev, Vladimir, Olga Kalinogorskaya, Ksenia Ivanova, et al. "In Vitro Selection of High-Level Beta-Lactam Resistance in Methicillin-Susceptible Staphylococcus aureus." Antibiotics 10, no. 6 (2021): 637. http://dx.doi.org/10.3390/antibiotics10060637.

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Selective pressure of beta-lactams is thought to be responsible for mutation selection in methicillin-susceptible Staphylococcus aureus (MSSA). We used next-generation sequencing to compare the genomes of beta-lactamase-positive (SA0707) and -negative (SA0937) MSSA isolates with their derivatives obtained after selection with oxacillin, ceftaroline, or meropenem. Selection with oxacillin and ceftaroline caused a rapid and significant (6–8 times) increase in the minimum inhibitory concentration (MICs) of oxacillin, penicillin, amoxicillin/clavulanate, and ceftaroline against the derivatives of

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Mlynarczyk-Bonikowska, Beata, Cezary Kowalewski, Aneta Krolak-Ulinska, and Wojciech Marusza. "Molecular Mechanisms of Drug Resistance in Staphylococcus aureus." International Journal of Molecular Sciences 23, no. 15 (2022): 8088. http://dx.doi.org/10.3390/ijms23158088.

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This paper discusses the mechanisms of S. aureus drug resistance including: (1) introduction. (2) resistance to beta-lactam antibiotics, with particular emphasis on the mec genes found in the Staphylococcaceae family, the structure and occurrence of SCCmec cassettes, as well as differences in the presence of some virulence genes and its expression in major epidemiological types and clones of HA-MRSA, CA-MRSA, and LA-MRSA strains. Other mechanisms of resistance to beta-lactam antibiotics will also be discussed, such as mutations in the gdpP gene, BORSA or MODSA phenotypes, as well as resistance

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Lumadya, Adi. "UKURAN PASAR UKURAN PASAR (Market Size) DAN INVESTASI ASING LANGSUNG DI ASEAN." JAE (JURNAL AKUNTANSI DAN EKONOMI) 1, no. 1 (2016): 26. http://dx.doi.org/10.29407/jae.v1i1.430.

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The main objective of this study was to examine the influence of some economic variables that include market size proxied with income per capita, economic growth, and exports to the Foreign Direct Investment in the member countries of ASEAN-9. The analytical tool used is the Least Squares Regression (Ordinary Least Square) and Panel Data. In the Data Panel will look for similarities in effect is Fixed (Fixed Effect) and the effect is Random (Random Effect). The results of the analysis are: Based on the analysis of OLS concluded that the variable size of the market (market siz

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Chen, Hongju, Jianping Yang, Yongjian Ding, Qingshan He, and Qin Ji. "Simulation of Daily Snow Depth Data in China Based on the NEX-GDDP." Water 13, no. 24 (2021): 3599. http://dx.doi.org/10.3390/w13243599.

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In this study, a backpropagation artificial neural network snow simulation model (BPANNSIM) is built using data collected from the National Climate Reference Station to obtain simulation data of China’s future daily snow depth in terms of representative concentration pathways (RCP4.5 and RCP8.5). The input layer of the BPANNSIM comprises the current day’s maximum temperature, minimum temperature, snow depth, and precipitation data, and the target layer comprises snow depth data of the following day. The model is trained and validated based on data from the National Climate Reference Station ov

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Pasara, Michael Takudzwa. "Economic Growth, Governance and Educational Sustainability: A VAR Analysis." Education Sciences 11, no. 7 (2021): 343. http://dx.doi.org/10.3390/educsci11070343.

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Quality educational institutions are strategic tools for accelerating the attainment of Sustainable Development Goals (SDGs). All the 17 SDGs are interlinked. For instance, quality education (SDG4) reduces poverty (SDG 1,2) and inequalities (SDG10) and stimulates good health and wellbeing (SDG3). The paper applied unorthodox theoretical postulations such as convergence models, intergovernmentalism, neofunctionalism and neorealism in explaining how functional (educational) institutions are a necessary enabling environment in accelerating the attainment of SDGs. Empirically, the paper identified

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Al Rahmad, Agus Hendra, Wiqayatun Khazanah, Teuku Alamsyah, and Emilda Emilda. "Pemberdayaan masyarakat melalui “Senam Sehat” untuk meningkatan aktifitas fisik serta penilaian kebugaran dan status gizi pada orang dewasa sebagai upaya preventif terhadap penyakit tidak menular." Jurnal PADE: Pengabdian & Edukasi 5, no. 2 (2023): 97. http://dx.doi.org/10.30867/pade.v5i2.1580.

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Indonesia merupakan salah satu negara berkembang yang mempunyai prevalensi Penyakit Tidak Menular (PTM) sangat signifikan. Saat ini PTM di Indonesia telah menjadi masalah kesehatan serta sebagai penyebab kematian dan serta merupakan ancaman terhadap kondisi ekonomi di Indonesia. Tujuan pengabdian masyarakat ini secara umum yaitu untuk memberdayakan masyarakat melalui “Senam Sehat” untuk meningkatan aktifitas fisik serta penilaian kebugaran dan status gizi pada orang dewasa sebagai upaya preventif terhadap penyakit tidak menular. Metode pengabdian dilakukan seperti intervensi “Senam Sehat”,peny

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Gostev, Vladimir V., O. E. Punchenko, and Sergey V. Sidorenko. "The current view on betalactam resistance in Staphylococcus aureus." Clinical Microbiology and Antimicrobial Chemotherapy 23, no. 4 (2021): 375–87. http://dx.doi.org/10.36488/cmac.2021.4.375-387.

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The review presents the current view on the different resistance mechanisms of Staphylococcus aureus to beta-lactams, which are ones of the main antibiotics of choice for the treatment of staphylococcal infections. Currently, there are several mechanisms of resistance such as production of staphylococcal beta-lactamase (blaZ), which provides resistance to penicillins and aminopenicillins. Another one is the presence of an alternative penicillin-binding protein (PBP2a), which is the main marker of methicillinresistant S. aureus (MRSA), virtually providing resistance to all beta-lactams, with th

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Rørvik, Gro Herredsvela, Krystyna Anna Liskiewicz, Fedor Kryuchkov, et al. "Cyclic Di-adenosine Monophosphate Regulates Metabolism and Growth in the Oral Commensal Streptococcus mitis." Microorganisms 8, no. 9 (2020): 1269. http://dx.doi.org/10.3390/microorganisms8091269.

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Cyclic di-adenosine monophosphate (c-di-AMP) has emerged as an important bacterial signaling molecule that functions both as an intracellular second messenger in bacterial cells and an extracellular ligand involved in bacteria-host cross-talk. In this study, we identify and characterize proteins involved in controlling the c-di-AMP concentration in the oral commensal and opportunistic pathogen Streptococcusmitis (S. mitis). We identified three known types of c-di-AMP turnover proteins in the genome of S. mitis CCUG31611: a CdaA-type diadenylate cyclase as well as GdpP-, and DhhP-type phosphodi

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Wang, Bing, and Tianchi Chen. "What do the sustainable development goals reveal, and are they sufficient for sustainable development?" PLOS ONE 19, no. 11 (2024): e0310089. http://dx.doi.org/10.1371/journal.pone.0310089.

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The Sustainable Development Goals (SDGs) adopted by the United Nations in 2015 represent the current perceptions of humans regarding understanding and monitoring development. Achieving all 17 goals simultaneously is unrealistic. Considering the interconnected nature of SDGs, identifying their critical dimensions, goals, indicators, and mutual relationships is necessary. In addition, with increasing reservations about the sustainability of SDGs, it is crucial to explore consistency across different dimensions to ensure policy coherence in maximizing synergies and minimizing trade-offs. Our stud

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Tuty Alawiyah Alimuddin. "Pengaruh Spiritual Mindfulness Based On Breathing Exercise terhadap Kecemasan, Kadar Glukosa Darah, dan Tekanan Darah Pasien Diabetes Melitus Tipe 2." Jurnal Pendidikan dan Teknologi Kesehatan 4, no. 1 (2021): 1–10. http://dx.doi.org/10.56467/jptk.v4i1.19.

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Pendahuluan: Perubahan mendadak dalam hidup membuat penderita DM menunjukkan beberapa reaksi psikologis negatif yang berakibat pada peningkatan tekanan darah (TD) dan glukosa darah. Tujuan penelitian ini untuk menjelaskan pengaruh spiritual mindfulness based on breathing exercise terhadap kecemasan, kadar glukosa darah, dan TD pada pasien DM tipe 2. Metode: Penelitian ini menggunakan quasy experimental study rancangan pre test dan post test with control group design dengan jumlah sampel 32 responden dan teknik sampling menggunakan purposive sampling. Intervensi dilakukan selama 4 minggu (15 me

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Sopova, Yu V., M. E. Velizhanina, D. A. Kandina, et al. "The Influence of a Deletion in the Noncatalytic Domain of GdpP Mediated by Genome Editing with CRISPR/Cas9 on the Phenotype of Staphylococcus aureus." Russian Journal of Genetics 59, no. 9 (2023): 970–73. http://dx.doi.org/10.1134/s1022795423090120.

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Lee, Seungjun, Jiwon Kim, and Jun Koo. "Beyond GDP: An Analysis of 25 Alternative Indices of GDP as Measures for National Welfare." Survey Research 22, no. 2 (2021): 33–70. http://dx.doi.org/10.20997/sr.22.2.2.

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Tetuko, Aji, and Diesty Anita Nugraheni. "ANALISIS EFEKTIFITAS BIAYA KOMBINASI ANTIDIABETIK ORAL PADA PASIEN RAWAT JALAN DIABETES MELITUS TIPE 2." Cendekia Journal of Pharmacy 5, no. 2 (2021): 105–16. http://dx.doi.org/10.31596/cjp.v5i2.156.

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Pembuatan keputusan dalam kebijakan farmasi di rumah sakit didukung oleh ilmu farmakoekonomi, antara lain keputusan terapi pasien yang cost effective, kebijakan formularium, kebijakan obat, dan alokasi sumber daya farmasi. American Diabetes Association (ADA) menyebutkan jumlah pasien DM yang tidak mencapai target terapi dengan monoterapi antidiabetika oral jumlahnya cukup banyak. Penggunaan akarbose atau metformin pada pasien NIDDM {Non Insulin Dependent Diabetes Mellitus) efektif digunakan sebagai kombinasi dengan sulfonilurea yang tidak terkendali dengan monoterapi sulfonilurea. Penelitian b

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Anh, Nguyen Thi Van, Phan Minh Khang, Tran Minh Thy, and Nguyen Ngoc Phuong Ngan. "GREEN ECONOMY WITH ECONOMIC GROWTH AND PER CAPITA INCOME IN VIETNAM." International Journal of Professional Business Review 9, no. 4 (2024): e04536. http://dx.doi.org/10.26668/businessreview/2024.v9i4.4536.

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Objective: The objective of this study is to investigate the green economy with economic growth and per capita income in Vietnam, to analyze the quantitative relationship among those factors, and to improve long-term green economic development in Vietnam towards sustainable national economic growth. Theoretical Framework: In this topic, the main concepts and theories that underpin the research are presented. The inverted U-shaped model of Kuznets; Green economy concept and regression model stand out, providing a solid basis for understanding the context of the investigation. Method: The method

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An, Ruofei, Xiaowu Hu, and Shucun Sun. "The Nonlinear Relationship Between Urbanization and Ecological Environment in China Under the PSR (Pressure-State-Response) Model: Inflection Point Identification and Policy Pathways." Sustainability 17, no. 10 (2025): 4450. https://doi.org/10.3390/su17104450.

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In the process of social development, there is a contradiction between economic development and the ecological environment. Western countries were the first to experience the inverted U-shaped development model of “destruction first and compensation later”, and China is also facing similar problems. To reveal the formation mechanism and dynamic evolution of the inflection point of ecological environment changes in China, this paper combines the entropy weight method, the analytic hierarchy process, and quadratic curve fitting to construct the “Ecological Pressure Index—GDPP Model” and studies

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Gundlach, Jan, Felix M. P. Mehne, Christina Herzberg, et al. "An Essential Poison: Synthesis and Degradation of Cyclic Di-AMP in Bacillus subtilis." Journal of Bacteriology 197, no. 20 (2015): 3265–74. http://dx.doi.org/10.1128/jb.00564-15.

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ABSTRACTGram-positive bacteria synthesize the second messenger cyclic di-AMP (c-di-AMP) to control cell wall and potassium homeostasis and to secure the integrity of their DNA. In the firmicutes, c-di-AMP is essential for growth. The model organismBacillus subtilisencodes three diadenylate cyclases and two potential phosphodiesterases to produce and degrade c-di-AMP, respectively. Among the three cyclases, CdaA is conserved in nearly all firmicutes, and this enzyme seems to be responsible for the c-di-AMP that is required for cell wall homeostasis. Here, we demonstrate that CdaA localizes to t

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