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Zeitschriftenartikel zum Thema „GPC1“

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Veröffentlicht am 1. April 2023

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1

Mucientes, A., E. Herranz, P. Lois, et al. "AB0077 CONTRIBUTION OF NOTUM TO THE DEVELOPMENT OF OSTEOARTHRITIS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1338.1–1339. http://dx.doi.org/10.1136/annrheumdis-2020-eular.4569.

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Background:Osteoarthritis (OA) is a degenerative disease characterized by altered homeostasis of joint cartilage and bone, the functionality of which relies on chondrocytes and osteoblasts, that leads to the formation of a defective extracellular matrix (ECM). The ECM plays an essential role in bone biology as it provides the structure of cartilage which serves as a template for bone formation. Collagen X, main component of the ECM, has been described by our group as down-regulated in OA [1]. Our data also points to an important role of the Wnt pathway in OA [1,2]. Furthermore, Wnt proteins ha

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Wang, Shiqing, Zhenzhen Wu, Minyu Zhou, and Wangjun Liao. "Effect of GPC1 on epithelial-to-mesenchymal transition and stemness and interaction with ITGB1 in gastric cancer." Journal of Clinical Oncology 35, no. 15_suppl (2017): e15580-e15580. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e15580.

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e15580 Background: Gastric cancer is the fourth frequently diagnosed cancer worldwide and tumor metastasis plays an important role in its poor prognosis. EMT, which occurs during embryonic development and carcinoma progression, contributes to metastasis and regulates stemness. GPC1, a member of the heparan sulfate proteoglycans family, is overexpressed in many types of cancer, and associates with metastasis and tumor progression. However, it is unknown that the functions of GPC1 and its underlying mechanism in gastric cancer. Methods: Immunohistochemistry analysis was performed in 245 GC tissu

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Lu, Fei, Shuran Chen, Weijun Shi, Xu Su, Huazhang Wu та Mulin Liu. "GPC1 promotes the growth and migration of colorectal cancer cells through regulating the TGF-β1/SMAD2 signaling pathway". PLOS ONE 17, № 6 (2022): e0269094. http://dx.doi.org/10.1371/journal.pone.0269094.

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In this study, we analyzed GPC family genes in colorectal cancer (CRC) and the possible mechanism of action of GPC1 in CRC. CRC patient data were extracted from The Cancer Genome Atlas, and the prognostic significance of GPC1 expression and its association with clinicopathological features were identified by Kolmogorov–Smirnov test. CRC patients with high GPC1 expression had poor overall survival compared with patients with low GPC1 expression. In vitro experiments demonstrated that knockdown of GPC1 significantly inhibited the proliferation and migration and promoted cell apoptosis in CRC cel

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Qiao, Dianhua, Xinhai Yang, Kristy Meyer, and Andreas Friedl. "Glypican-1 Regulates Anaphase Promoting Complex/Cyclosome Substrates and Cell Cycle Progression in Endothelial Cells." Molecular Biology of the Cell 19, no. 7 (2008): 2789–801. http://dx.doi.org/10.1091/mbc.e07-10-1025.

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Glypican-1 (GPC1), a member of the mammalian glypican family of heparan sulfate proteoglycans, is highly expressed in glioma blood vessel endothelial cells (ECs). In this study, we investigated the role of GPC1 in EC replication by manipulating GPC1 expression in cultured mouse brain ECs. Moderate GPC1 overexpression stimulates EC growth, but proliferation is significantly suppressed when GPC1 expression is either knocked down or the molecule is highly overexpressed. Flow cytometric and biochemical analyses show that high or low expression of GPC1 causes cell cycle arrest at mitosis or the G2

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Qiao, Dianhua, Kristy Meyer, and Andreas Friedl. "Glypican 1 Stimulates S Phase Entry and DNA Replication in Human Glioma Cells and Normal Astrocytes." Molecular and Cellular Biology 33, no. 22 (2013): 4408–21. http://dx.doi.org/10.1128/mcb.00238-13.

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Malignant gliomas are highly lethal neoplasms with limited treatment options. We previously found that the heparan sulfate proteoglycan glypican 1 (GPC1) is universally and highly expressed in human gliomas. In this study, we investigated the biological activity of GPC1 expression in both human glioma cells and normal astrocytesin vitro. Expression of GPC1 inactivates the G1/S checkpoint and strongly stimulates DNA replication. Constitutive expression of GPC1 causes DNA rereplication and DNA damage, suggesting a mutagenic activity for GPC1. GPC1 expression leads to a significant downregulation

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Liu, Ying, Hui Ren, Mu-qing Yang, and Ji-yu Li. "GPC1 Is Associated with Poor Prognosis and Treg Infiltration in Colon Adenocarcinoma." Computational and Mathematical Methods in Medicine 2022 (September 14, 2022): 1–15. http://dx.doi.org/10.1155/2022/8209700.

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Glypican-1 (GPC1) is a glycosylated protein recognized as a promising biomarker for cancer. Nonetheless, there have been few systematic studies on GPC1 in colon adenocarcinoma (COAD). We conducted bioinformatic analysis based on The Cancer Genome Atlas (TCGA) and used clinical samples to verify that GPC1 is overexpressed in colon adenocarcinoma. Kaplan-Meier analysis showed that higher GPC1 expression was associated with poor overall survival (OS). The Cox regression model further showed that GPC1 expression is an independent negative prognostic factor for COAD. Gene set enrichment analysis de

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Schlaepfer Sales, Caroline B., Vanessa S. N. Guimarães, Ludmila F. Valverde, et al. "Glypican-1, -3, -5 (GPC1, GPC3, GPC5) and Hedgehog Pathway Expression in Oral Squamous Cell Carcinoma." Applied Immunohistochemistry & Molecular Morphology 29, no. 5 (2021): 345–51. http://dx.doi.org/10.1097/pai.0000000000000907.

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Whipple, Chery A., Arthur D. Lander, and Murray Korc. "Discovery of a Novel Molecule that Regulates Tumor Growth and Metastasis." Scientific World JOURNAL 8 (2008): 1250–53. http://dx.doi.org/10.1100/tsw.2008.152.

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The heparan sulfate proteoglycan, Glypican-1 (GPC1), significantly impacts the growth of pancreatic cancer cellsin vivoand markedly attenuates tumor angiogenesis and metastasis in athymic mice. Interestingly, both cancer cell–derived and host-derived GPC1 play an important role in tumor development and spread. These data suggest that GPC1 may be a valid therapeutic target for pancreatic cancer.

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Khurana, Satish, Chacko Joseph, Lia Margamuljana, Shannon Buckley, Sarah Scouteden, and Catherine M. Verfaillie. "Tissue Factor Pathway Inhibitor Increases Hematopoietic Stem Cell Homing and Engraftment by Glypican-3 Mediated Inhibition of CD26 Activity." Blood 118, no. 21 (2011): 725. http://dx.doi.org/10.1182/blood.v118.21.725.725.

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Abstract Abstract 725 Directional migration is an important factor that determines homing of transplanted hematopoietic stem cells (HSC). The SDF-1α-CXCR4 axis is one of the most important determinants of this process. CD26, expressed on various cell types, leads to proteolytic cleavage of SDF-1α, which leads to the inactivation of its chemokine activity. We identified tissue factor pathway inhibitor (TFPI) as an inhibitor of CD26. Culture of murine bone marrow derived c-kit+Lin−Sca-1+ (KLS) cells or human umbilical cord blood derived Lin−CD34+ cells with TFPI significantly inhibited CD26 acti

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Qiu, Wenli, Huifeng Zhang, Xiao Chen, et al. "A GPC1-targeted and gemcitabine-loaded biocompatible nanoplatform for pancreatic cancer multimodal imaging and therapy." Nanomedicine 14, no. 17 (2019): 2339–53. http://dx.doi.org/10.2217/nnm-2019-0063.

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Aim: Biomarker-targeted nanocarrier holds promise for early diagnosis and effective therapy of cancer. Materials & methods: This work successfully designs and evaluates GPC1-targeted, gemcitabine (GEM)-loaded multifunctional gold nanocarrier for near-infrared fluorescence (NIRF)/MRI and targeted chemotherapy against pancreatic cancer in vitro and in vivo. Results: Blood biochemical and histological analyses show that the in vivo toxicity of GPC1-GEM-nanoparticles (NPs) was negligible. Both in vitro and in vivo studies demonstrate that GPC1-GEM-NPs can be used as NIRF/MR contrast agent for

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Colin-Pierre, Charlie, Valérie Untereiner, Ganesh D. Sockalingum, Laurent Ramont, and Stéphane Brézillon. "Investigation of Glypican-4 and -6 by Infrared Spectral Imaging during the Hair Growth Cycle." International Journal of Molecular Sciences 24, no. 5 (2023): 4291. http://dx.doi.org/10.3390/ijms24054291.

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The expression of glypicans in different hair follicle (HF) compartments is still poorly understood. Heparan sulfate proteoglycans (HSPGs) distribution in HF is classically investigated by conventional histology, biochemical analysis, and immunohistochemistry. Our previous study proposed a novel approach to assess hair histology and glypican-1 (GPC1) distribution changes in the HF at different phases of the hair growth cycle using infrared spectral imaging (IRSI). We show in the present manuscript for the first time complementary data on the distribution of glypican-4 (GPC4) and glypican-6 (GP

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Kaushik, Nikita. "A Possible Role of Pulegone against Glypican-1 for the Treatment of Alzheimer’s Disease through In-Silico Approach." International Journal for Research in Applied Science and Engineering Technology 9, no. VI (2021): 4000–4007. http://dx.doi.org/10.22214/ijraset.2021.35932.

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Alzheimer’s disease (AD) dementia is a type of neurodegenerative disease, refers to a distinct arrival and certainly functional and mental decline which is linked with age which eventually leads to death. This current study was to demonstrate the role of pulegone against Glypican-1 for the treatment of Alzheimer’s disease through an in-silico approach. Methods: All the information and studies were gleaned from molecular docking. With the use of docking software, Docking was implemented between the target protein GPC1 (PDB ID: 4YWT) and the entire ligands. We preferred GPC1 (PDB ID: 4YWT) as a

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Papiewska-Pająk, Izabela, Damian Krzyżanowski, Maria Katela, et al. "Glypican-1 Level Is Elevated in Extracellular Vesicles Released from MC38 Colon Adenocarcinoma Cells Overexpressing Snail." Cells 9, no. 7 (2020): 1585. http://dx.doi.org/10.3390/cells9071585.

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The transcription factor Snail triggers epithelial-to-mesenchymal transition (EMT), endowing cancer cells with invasive properties during tumor progression. Extracellular vesicles (EVs) released from cancer cells at various stages of cancer progression are known to influence the tumor pre-metastatic niche and metastatic potential. The aim of this study was to analyze the effect of Snail on murine colon adenocarcinoma cells (MC38 line) and on the characteristics of their EVs. Stable clones of Snail-overexpressing MC38 cells were investigated in vitro versus Mock cells. Increased expression of m

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Huang, Mi, Yingying Ma, Xiaoyan Gao, et al. "Combining Fluorescent Cell Sorting and Single B Cell Amplification to Screen the Monoclonal Antibody Gene against Human Glypican-1 in Pancreatic Cancer." Journal of Oncology 2021 (September 3, 2021): 1–8. http://dx.doi.org/10.1155/2021/5646589.

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In this report, one novel method has been developed to screen the monoclonal antibody against human pancreatic cancer biomarker glypican-1 (GPC1) through the combination of fluorescent cell sorting and single B cell amplification. GPC1-positive B cells were sorted out from the peripheral blood mononuclear cells (PBMCs) by fluorescent cell sorting after the GPC1 immunization to the New Zealand white rabbit. Then, total RNA was extracted and reversely transcribed into cDNA, which was used as the template, and the variable region sequences of both heavy and light chains were amplified from the sa

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Dwivedi, Prem P., Randall H. Grose, Jorge Filmus, et al. "Regulation of bone morphogenetic protein signalling and cranial osteogenesis by Gpc1 and Gpc3." Bone 55, no. 2 (2013): 367–76. http://dx.doi.org/10.1016/j.bone.2013.04.013.

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Buscail, Etienne, Catherine Alix-Panabières, Pascaline Quincy, et al. "High Clinical Value of Liquid Biopsy to Detect Circulating Tumor Cells and Tumor Exosomes in Pancreatic Ductal Adenocarcinoma Patients Eligible for Up-Front Surgery." Cancers 11, no. 11 (2019): 1656. http://dx.doi.org/10.3390/cancers11111656.

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Purpose: Expediting the diagnosis of pancreatic ductal adenocarcinoma (PDAC) would benefit care management, especially for the start of treatments requiring histological evidence. This study evaluated the combined diagnostic performance of circulating biomarkers obtained by peripheral and portal blood liquid biopsy in patients with resectable PDAC. Experimental design: Liquid biopsies were performed in a prospective translational clinical trial (PANC-CTC #NCT03032913) including 22 patients with resectable PDAC and 28 noncancer controls from February to November 2017. Circulating tumor cells (C

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Busato, Davide, Monica Mossenta, Michele Dal Bo, Paolo Macor, and Giuseppe Toffoli. "The Proteoglycan Glypican-1 as a Possible Candidate for Innovative Targeted Therapeutic Strategies for Pancreatic Ductal Adenocarcinoma." International Journal of Molecular Sciences 23, no. 18 (2022): 10279. http://dx.doi.org/10.3390/ijms231810279.

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Pancreatic ductal adenocarcinoma (PDAC) accounts for 90% of all pancreatic cancers, with a 5-year survival rate of 7% and 80% of patients diagnosed with advanced or metastatic malignancies. Despite recent advances in diagnostic testing, surgical techniques, and systemic therapies, there remain limited options for the effective treatment of PDAC. There is an urgent need to develop targeted therapies that are able to differentiate between cancerous and non-cancerous cells to reduce side effects and better inhibit tumor growth. Antibody-targeted strategies are a potentially effective option for i

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Estevão, Bianca Martins, Edson José Comparetti, Nathalia Cristina Rissi, and Valtencir Zucolotto. "Anti-GPC1-modified mesoporous silica nanoparticles as nanocarriers for combination therapy and targeting of PANC-1 cells." Materials Advances 2, no. 15 (2021): 5224–35. http://dx.doi.org/10.1039/d1ma00225b.

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We present a novel therapeutic nanoplatform based on mesoporous silica nanoparticles encapsulating ferulic acid/gemcitabine and functionalized with anti-GPC1 antibodies to target human pancreatic cancer (PANC-1) cells.

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Grillo, Paulina Karin, Balázs Győrffy, and Martin Götte. "Prognostic impact of the glypican family of heparan sulfate proteoglycans on the survival of breast cancer patients." Journal of Cancer Research and Clinical Oncology 147, no. 7 (2021): 1937–55. http://dx.doi.org/10.1007/s00432-021-03597-4.

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Abstract Purpose Dysregulated expression of proteoglycans influences the outcome and progression of numerous cancers. Several studies have investigated the role of individual glypicans in cancer, however, the impact of the whole glypican family of heparan sulfate proteoglycans on prognosis of a large patient cohort of breast cancer patients has not yet been investigated. In the present study, our aim was to investigate the prognostic power of the glypicans in breast cancer patients. Methods We used a public database including both gene expression data and survival information for 3951 breast c

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de Boer, T. J. L., M. E. Huber, E. A. Magnier, et al. "Characterizing Crosstalk within the Pan-STARRS GPC1 Camera." Publications of the Astronomical Society of the Pacific 134, no. 1032 (2022): 024501. http://dx.doi.org/10.1088/1538-3873/ac4de3.

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Abstract Using data from a year-long dedicated campaign to observe bright stars, we study the crosstalk channels present in the GPC1 camera. By analyzing these data, we construct a data set that checks source stars on almost every CCD of every chip within the camera against all possible crosstalk destinations. We use a clustering algorithm to find potential crosstalk occurrences, and then also check all possible combinations (driven by the hardware layout) by eye. This results in a total of 640 rules, with a flux attenuation factor ranging from 2.5 × 102 for the bright end to 2.5 × 104 at the

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Tanaka, Mariko, Shumpei Ishikawa, Tetsuo Ushiku, et al. "EVI1 modulates oncogenic role of GPC1 in pancreatic carcinogenesis." Oncotarget 8, no. 59 (2017): 99552–66. http://dx.doi.org/10.18632/oncotarget.20601.

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Filmus, Jorge. "The function of glypicans in the mammalian embryo." American Journal of Physiology-Cell Physiology 322, no. 4 (2022): C694—C698. http://dx.doi.org/10.1152/ajpcell.00045.2022.

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Glypicans are proteoglycans that are bound to the outer surface of the plasma membrane by a glycosylphosphatidylinositol anchor. The mammalian genome contains six members of the glypican family ( GPC1 to GPC6). Although the degree of sequence homology within the family is rather low, the three-dimensional structure of these proteoglycans is highly conserved. Glypicans are predominantly expressed during embryonic development. Genetic and biochemical studies have shown that glypicans can stimulate or inhibit the signaling pathways triggered by Wnts, hedgehogs, fibroblast growth factors, and bone

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Lorente-Gea, Laura, Beatriz García, Carla Martín, et al. "Heparan Sulfate Proteoglycans Undergo Differential Expression Alterations in Alzheimer Disease Brains." Journal of Neuropathology & Experimental Neurology 79, no. 5 (2020): 474–83. http://dx.doi.org/10.1093/jnen/nlaa016.

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Abstract Previous studies have reported that heparan sulfate proteoglycans (HSPGs) promote amyloid-beta peptide and tau fibrillization in Alzheimer disease (AD) and provide resistance against proteolytic breakdown. We compared the expression levels of 17 HSPG core proteins in 18 AD cases and 6 controls. RT-PCR was used to analyze transcription levels. Immunohistochemistry was performed to localize HSPGs in the brain tissue. We detected expression of all HSPG genes investigated. SDC1, GPC3, and CD44v3 showed the lowest levels of expression, while SDC3 and GPC1 showed the highest. Remarkably, SD

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Kong, Chunli, Lianghui Cheng, Guido Krenning, et al. "Human Milk Oligosaccharides Mediate the Crosstalk Between Intestinal Epithelial Caco-2 Cells and Lactobacillus PlantarumWCFS1in an In Vitro Model with Intestinal Peristaltic Shear Force." Journal of Nutrition 150, no. 8 (2020): 2077–88. http://dx.doi.org/10.1093/jn/nxaa162.

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ABSTRACT Background The intestinal epithelial cells, food molecules, and gut microbiota are continuously exposed to intestinal peristaltic shear force. Shear force may impact the crosstalk of human milk oligosaccharides (hMOs) with commensal bacteria and intestinal epithelial cells. Objectives We investigated how hMOs combined with intestinal peristaltic shear force impact intestinal epithelial cells and crosstalk with a commensal bacterium. Methods We applied the Ibidi system to mimic intestinal peristaltic shear force. Caco-2 cells were exposed to a shear force (5 dynes/cm2) for 3 d, and the

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Girerd, Sandrine, Lucie Tosca, Olivier Herault, et al. "Superoxide Dismutase 2 (Sod2) Expression Is Highly Decreased In Chronic Myeloid Leukemia (CML): Contribution To Genetic Instability In Bcr-Abl-Expressing Leukemic Cells." Blood 122, no. 21 (2013): 3980. http://dx.doi.org/10.1182/blood.v122.21.3980.3980.

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Abstract A increased oxidative stress is one of the hallmarks of chronic myeloid leukemia (CML). Manganese Superoxide dismutase 2 (SOD2) is a key scavenger enzyme against reactive oxygen species (ROS) in eukaryotic cells, playing a crucial role in antioxidant defense but its potential implication in the CML pathophysiology is not determined. We have analyzed the expression of SOD2 at the RNA level in a large cohort of CML patients (n=49) compared to a cohort of controls with non-malignant hyperleucocytosis (n= 19). This analysis showed a major decrease of SOD2 mRNA, inversely correlated with l

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Asundi, Vinod K., Bonnie F. Keister, and David J. Carey. "Organization, 5′-flanking sequence and promoter activity of the rat GPC1 gene." Gene 206, no. 2 (1998): 255–61. http://dx.doi.org/10.1016/s0378-1119(97)00594-5.

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Perrot, G., C. Colin-Pierre, L. Ramont, et al. "Decreased expression of GPC1 in human skin keratinocytes and epidermis during ageing." Experimental Gerontology 126 (October 2019): 110693. http://dx.doi.org/10.1016/j.exger.2019.110693.

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Bai, Mei-Rong, Wei-Bo Niu, Ying Zhou, et al. "Association of common variation in ADD3 and GPC1 with biliary atresia susceptibility." Aging 12, no. 8 (2020): 7163–82. http://dx.doi.org/10.18632/aging.103067.

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Smith, Katherine. "GPC1 genetic risk further links Hedgehog signalling with pathogenesis of biliary atresia." Nature Reviews Gastroenterology & Hepatology 10, no. 3 (2013): 127. http://dx.doi.org/10.1038/nrgastro.2013.20.

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Rzhevskiy, Alexey S., Sajad Razavi Bazaz, Lin Ding, et al. "Rapid and Label-Free Isolation of Tumour Cells from the Urine of Patients with Localised Prostate Cancer Using Inertial Microfluidics." Cancers 12, no. 1 (2019): 81. http://dx.doi.org/10.3390/cancers12010081.

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During the last decade, isolation of circulating tumour cells via blood liquid biopsy of prostate cancer (PCa) has attracted significant attention as an alternative, or substitute, to conventional diagnostic tests. However, it was previously determined that localised forms of PCa shed a small number of cancer cells into the bloodstream, and a large volume of blood is required just for a single test, which is impractical. To address this issue, urine has been used as an alternative to blood for liquid biopsy as a truly non-invasive, patient-friendly test. To this end, we developed a spiral micr

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Xiong, Lei, Xiao Li, Dongsheng Chen, Si Li, and Liguo Luo. "GPC1-ALK: A novel ALK fusion in a patient with pulmonary sarcomatoid carcinoma." Lung Cancer 151 (January 2021): 104–5. http://dx.doi.org/10.1016/j.lungcan.2020.11.021.

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Cui, Shuang, Melissa Leyva–Vega, Ellen A. Tsai, et al. "Evidence From Human and Zebrafish That GPC1 Is a Biliary Atresia Susceptibility Gene." Gastroenterology 144, no. 5 (2013): 1107–15. http://dx.doi.org/10.1053/j.gastro.2013.01.022.

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King, Will Ray, and Jana Patton-Vogt. "Role of the Candida albicans glycerophosphocholine acyltransferase, Gpc1, in phosphatidylcholine biosynthesis and cell physiology." FASEB Journal 34, S1 (2020): 1. http://dx.doi.org/10.1096/fasebj.2020.34.s1.05461.

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Palmer, Daniel A., Jill K. Thompson, Lie Li, Ashton Prat та Ping Wang. "Gib2, A Novel Gβ-like/RACK1 Homolog, Functions as a Gβ Subunit in cAMP Signaling and Is Essential in Cryptococcus neoformans". Journal of Biological Chemistry 281, № 43 (2006): 32596–605. http://dx.doi.org/10.1074/jbc.m602768200.

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Canonical G proteins are heterotrimeric, consisting of α, β, and γ subunits. Despite multiple Gα subunits functioning in fungi, only a single Gβ subunit per species has been identified, suggesting that non-conventional G protein signaling exists in this diverse group of eukaryotic organisms. Using the Gα subunit Gpa1 that functions in cAMP signaling as bait in a two-hybrid screen, we have identified a novel Gβ-like/RACK1 protein homolog, Gib2, from the human pathogenic fungus Cryptococcus neoformans. Gib2 contains a seven WD-40 repeat motif and is predicted to form a seven-bladed β propeller s

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Hasandoost, Leyla, Daniella Marx, Paul Zalzal, et al. "Comparative Evaluation of Two Glass Polyalkenoate Cements: An In Vivo Pilot Study Using a Sheep Model." Journal of Functional Biomaterials 12, no. 3 (2021): 44. http://dx.doi.org/10.3390/jfb12030044.

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Poly(methyl methacrylate) (PMMA) is used to manage bone loss in revision total knee arthroplasty (rTKA). However, the application of PMMA has been associated with complications such as volumetric shrinkage, necrosis, wear debris, and loosening. Glass polyalkenoate cements (GPCs) have potential bone cementation applications. Unlike PMMA, GPC does not undergo volumetric shrinkage, adheres chemically to bone, and does not undergo an exothermic setting reaction. In this study, two different compositions of GPCs (GPCA and GPCB), based on the patented glass system SiO2-CaO-SrO-P2O5-Ta2O5, were inves

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Qiu, Wenli, Rong Chen, Xiao Chen, et al. "Oridonin-loaded and GPC1-targeted gold nanoparticles for multimodal imaging and therapy in pancreatic cancer." International Journal of Nanomedicine Volume 13 (October 2018): 6809–27. http://dx.doi.org/10.2147/ijn.s177993.

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Ke, Juntao, Shuaidan Zeng, Jianxiong Mao, et al. "Common genetic variants of GPC1 gene reduce risk of biliary atresia in a Chinese population." Journal of Pediatric Surgery 51, no. 10 (2016): 1661–64. http://dx.doi.org/10.1016/j.jpedsurg.2016.05.009.

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Vermeesch, Joris R., Griet Mertens, Guido David, and Peter Marynen. "Assignment of the human glypican gene (GPC1) to 2q35–q37 by fluorescence in situ hybridization." Genomics 25, no. 1 (1995): 327–29. http://dx.doi.org/10.1016/0888-7543(95)80152-c.

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Li, Nan, Dan Li, Jiajia Pan, Raul Cachau, and Mitchell Ho. "Abstract 549: The IgG4 hinge with CD28 transmembrane domain mediates CAR dimerization and improves the activity of glypican 1-targeted CAR T cells in pancreatic cancer." Cancer Research 82, no. 12_Supplement (2022): 549. http://dx.doi.org/10.1158/1538-7445.am2022-549.

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Abstract Low antigen density has been suggested as a major cause of insufficient antitumor activity of chimeric antigen receptor (CAR) T cells. The impact of the hinge and the transmembrane (TM) domain on modulating CAR T cell reactivity is important to investigate. Here, we isolated a camel nanobody D4 recognizing glypican 1 (GPC1), a cell surface proteoglycan that is expressed in pancreatic cancer. We constructed a series of D4 4-1BBζ CARs differing only by their hinge (CD8 or IgG4) and TM (CD8 or CD28). D4 CARs containing a mutated IgG4 hinge and the CD28 TM, but not CD8 hinge with either T

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Karihaloo, Anil, Sujata Kale, Norman D. Rosenblum, and Lloyd G. Cantley. "Hepatocyte Growth Factor-Mediated Renal Epithelial Branching Morphogenesis Is Regulated by Glypican-4 Expression." Molecular and Cellular Biology 24, no. 19 (2004): 8745–52. http://dx.doi.org/10.1128/mcb.24.19.8745-8752.2004.

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ABSTRACT The glypican (Gpc) family of cell surface heparan sulfate proteoglycans are expressed in a tissue-specific and developmentally regulated fashion. To determine if individual Gpcs can modulate heparin-binding growth factor signaling, we examined hepatocyte growth factor (HGF)-stimulated mitogenic, motogenic, and morphogenic responses of renal tubular cells expressing different Gpcs. Adult inner medullary collecting duct (IMCD) cells were found to express primarily Gpc4 and to proliferate, migrate, and form tubules with HGF, correlating with sustained extracellular signal-regulated kinas

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Li, Jian, Bo Li, Caiping Ren, et al. "The clinical significance of circulating GPC1 positive exosomes and its regulative miRNAs in colon cancer patients." Oncotarget 8, no. 60 (2017): 101189–202. http://dx.doi.org/10.18632/oncotarget.20516.

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Kong, Yuan-Mei, Ke Yuan, and Chun-Lin Wang. "Congenital biliary atresia caused by GPC1 gene mutation in Chinese siblings: A case report." World Journal of Clinical Cases 11, no. 3 (2023): 629–34. http://dx.doi.org/10.12998/wjcc.v11.i3.629.

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Li, Fuchuan, Wen Shi, Mariana Capurro, and Jorge Filmus. "Glypican-5 stimulates rhabdomyosarcoma cell proliferation by activating Hedgehog signaling." Journal of Cell Biology 192, no. 4 (2011): 691–704. http://dx.doi.org/10.1083/jcb.201008087.

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Glypican-5 (GPC5) is one of the six members of the glypican family. It has been previously reported that GPC5 stimulates the proliferation of rhabdomyosarcoma cells. In this study, we show that this stimulatory activity of GPC5 is a result of its ability to promote Hedgehog (Hh) signaling. We have previously shown that GPC3, another member of the glypican family, inhibits Hh signaling by competing with Patched 1 (Ptc1) for Hh binding. Furthermore, we showed that GPC3 binds to Hh through its core protein but not to Ptc1. In this paper, we demonstrate that GPC5 increases the binding of Sonic Hh

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Hong, Wei, Tingting Zhang, Junbin Yan, et al. "Bioinformatics analysis of an animal model of diet-induced nonalcoholic fatty liver disease with rapid progression." Experimental Biology and Medicine 247, no. 3 (2021): 263–75. http://dx.doi.org/10.1177/15353702211055099.

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Nonalcoholic fatty liver disease (NAFLD) develops rapidly in high-fat diet (HFD) fed Mongolian gerbil ( Meriones unguiculatus). Here, we aim to explore the gene expression characteristics of Mongolian gerbil to better understand the underlying mechanism in this animal model. Mongolian gerbils were fed with normal diet or HFD for different periods. High-throughput sequencing was carried out on the hepatic mRNA and bioinformatics analysis was further performed. Eight hub genes Cd44, App, Cdc42, Cd68, Cxcr4, Csf1r, Adgre1, and Fermt3, which were involved in inflammation, fibrosis, and HCC were ob

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Behrangi, Ali, Alex Gardner, John T. Reager, et al. "Using GRACE to Estitmate Snowfall Accumulation and Assess Gauge Undercatch Corrections in High Latitudes." Journal of Climate 31, no. 21 (2018): 8689–704. http://dx.doi.org/10.1175/jcli-d-18-0163.1.

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Ten years of terrestrial water storage anomalies from the Gravity Recovery and Climate Experiment (GRACE) were used to estimate high-latitude snowfall accumulation using a mass balance approach. The estimates were used to assess two common gauge-undercatch correction factors (CFs): the Legates climatology (CF-L) utilized in the Global Precipitation Climatology Project (GPCP) and the Fuchs dynamic correction model (CF-F) used in the Global Precipitation Climatology Centre (GPCC) monitoring product. The two CFs can be different by more than 50%. CF-L tended to exceed CF-F over northern Asia and

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Buscail, Etienne, Alexandre Chauvet, Pascaline Quincy, et al. "CD63-GPC1-Positive Exosomes Coupled with CA19-9 Offer Good Diagnostic Potential for Resectable Pancreatic Ductal Adenocarcinoma." Translational Oncology 12, no. 11 (2019): 1395–403. http://dx.doi.org/10.1016/j.tranon.2019.07.009.

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Zhang, Qin, Dennis K. Jeppesen, James N. Higginbotham, et al. "Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets." Nature Cell Biology 23, no. 12 (2021): 1240–54. http://dx.doi.org/10.1038/s41556-021-00805-8.

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AbstractExtracellular vesicles and exomere nanoparticles are under intense investigation as sources of clinically relevant cargo. Here we report the discovery of a distinct extracellular nanoparticle, termed supermere. Supermeres are morphologically distinct from exomeres and display a markedly greater uptake in vivo compared with small extracellular vesicles and exomeres. The protein and RNA composition of supermeres differs from small extracellular vesicles and exomeres. Supermeres are highly enriched with cargo involved in multiple cancers (glycolytic enzymes, TGFBI, miR-1246, MET, GPC1 and

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Sergi, Consolato M., and Susan Gilmour. "Biliary Atresia: A Complex Hepatobiliary Disease with Variable Gene Involvement, Diagnostic Procedures, and Prognosis." Diagnostics 12, no. 2 (2022): 330. http://dx.doi.org/10.3390/diagnostics12020330.

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The diagnosis of biliary atresia is still terrifying at the 3rd decade of the 21st century. In a department of neonatal intensive care unit, parents and physicians face a challenge with a jaundiced baby, who may or may not have a surgically correctable hepatopathy. The approach has been systematically evaluated, but the etiology remains ambiguous. The study of families with recurrent biliary atresia has been undertaken at a molecular level. The primary interest with this disease is to identify the etiology and change the treatment from symptomatic to curative. The occurrence of this obstructiv

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Li, Chunlong, Xuefei Du, Sheng Tai, et al. "GPC1 Regulated by miR-96-5p, Rather than miR-182-5p, in Inhibition of Pancreatic Carcinoma Cell Proliferation." International Journal of Molecular Sciences 15, no. 4 (2014): 6314–27. http://dx.doi.org/10.3390/ijms15046314.

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Goshu, Habtamu Abera, Min Chu, Xiaoyun Wu, Bao Pengjia, Xue Zhi Ding, and Ping Yan. "Association study and expression analysis of GPC1 gene copy number variation in Chinese Datong yak (Bos grunniens) breed." Italian Journal of Animal Science 18, no. 1 (2019): 820–32. http://dx.doi.org/10.1080/1828051x.2019.1586456.

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