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Dissertationen zum Thema „Heterocyclic compounds“

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1

Locke, Julie Myree, University of Western Sydney, College of Health and Science, and School of Biomedical and Health Sciences. "Synthetic and conformational studies of hexahydropyrimidines and related heterocycles." THESIS_CHS_BHS_Locke_J.xml, 2003. http://handle.uws.edu.au:8081/1959.7/638.

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This thesis explores the synthesis and conformational behaviour of hexahydropyrimidines and related heterocycles, with particular emphasis on 5- hyrdohexahydropyrimidines. The conformational behaviour of these compounds was investigated using dynamic NMR spectroscopy, molecular modelling techniques and X-ray crystal structure analysis. The conformational behaviour of 5- hyrdohexahydropyrimidine, hexahydropyrimidine and their analogous oxygen compounds as well as a series of hexahydropyrimidines with various exocyclic substituents, were examined. The preferred conformations of all these compoun
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2

Hu, Gang. "Conducting polymers from heterocyclic compounds." Thesis, Open University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240331.

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3

Armugam, S. "Studies on N-Heterocyclic Compounds." Thesis, Indian Institute of Science, 1994. https://etd.iisc.ac.in/handle/2005/108.

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The thesis entitled "Studies on N-Hetero cyclic Compounds: (a) Reaction of 5,6,7,8-Tetrahydroisoquinolines with Vilsmeier Reagent and (b) Amide Induced in situ Alkylation of 5,6-Dihydroisoquinolines" is presented in two parts. Part I involves a study of the Vilsmeier reaction of 4-cyano-1,3-dihydroxy-5,6,7,8 tetrahydroisoquinoline derivatives, while Part II concerns the in situ alkylation of l-alkyl-4-cyano-3-methoxy-5,6- dihydroisoquinolines in presence of KNH2/liq.NH3.
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4

Armugam, S. "Studies on N-Heterocyclic Compounds." Thesis, Indian Institute of Science, 1994. http://hdl.handle.net/2005/108.

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The thesis entitled "Studies on N-Hetero cyclic Compounds: (a) Reaction of 5,6,7,8-Tetrahydroisoquinolines with Vilsmeier Reagent and (b) Amide Induced in situ Alkylation of 5,6-Dihydroisoquinolines" is presented in two parts. Part I involves a study of the Vilsmeier reaction of 4-cyano-1,3-dihydroxy-5,6,7,8 tetrahydroisoquinoline derivatives, while Part II concerns the in situ alkylation of l-alkyl-4-cyano-3-methoxy-5,6- dihydroisoquinolines in presence of KNH2/liq.NH3.
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5

Nyoni, Dubekile. "Application of the Baylis-Hillman methodology in the construction of novel heterocyclic derivatives." Thesis, Rhodes University, 2008. http://eprints.ru.ac.za/1134/.

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6

Miah, Soyfur. "The metallocarbene route to heterocyclic compounds." Thesis, Loughborough University, 1997. https://dspace.lboro.ac.uk/2134/26972.

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7

Wilson, Jennifer M. "Synthesis of biologically active heterocyclic compounds." Thesis, University of Glasgow, 2007. http://theses.gla.ac.uk/45/.

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More than 11 million people worldwide are diagnosed with cancer every year. New cancer drugs are required that are more effective and selective. Nitrogen mustard alkylating agents crosslink DNA inhibiting transcription and replication. Use of the mustard pharmacophore as part of a macrocycle allows metal complexation and produces a prodrug. Hypoxic tumour cells have increased concentrations of reductase enzymes which could lead to reduction of the complex in situ and release of a cytotoxic drug. Human African Trypanosomiasis is commonly known as Sleeping Sickness and affects over 36 countries
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8

MacDonald, Ranald John. "Novel routes to heterocyclic Azo compounds." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5787.

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The potential use of electron-deficient heterocyclic azo compounds as inkjet dyes was explored. 2-Nitrosopyridine could be used to form a series of azo compounds via the Mills’ reaction with electron-rich aromatic amines. Conditions for this process were optimised by varying solvent and pH. In the presence of ethers, 2-nitrosopyridine is quickly reduced to azoxypyridine. This reaction follows first order kinetics; diethyl and diisopropyl ether react at similar rates, whereas cyclic ethers such as THF are far slower. Organic bases such as Hunigs base were also found to promote formation of azox
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9

Jamalis, Joazaizulfazli. "Synthesis of heterocyclic containing oxygen compounds." Thesis, University of Bristol, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.529847.

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10

Lee, On-yi. "Synthesis of heterocycles via phenylseleno group transfer radical cyclization and chemoselective reductive amination promoted by InCl3." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/HKUTO/record/B3955756X.

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11

Duan, Gongping. "Design, synthesis, and photophysics and photochromic study of dithienylethene-containing heterocyclic derivatives and N-heterocyclic carbene-ruthenium (II) complexes." Click to view the E-thesis via HKUTO, 2010. http://sunzi.lib.hku.hk/hkuto/record/B44248246.

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12

Williams, Christopher Ian. "A computational study of nitrogen heterocyclic compounds." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq30417.pdf.

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13

Harper, Mark F. "Studies on heterocyclic compounds related to anthracyclines." Thesis, Heriot-Watt University, 1985. http://hdl.handle.net/10399/1613.

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14

Crockett, Rowena. "Generation of free radicals from heterocyclic compounds." Thesis, University of Aberdeen, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.290239.

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Tetrazolinones, thiatriazole 1-oxides and meso-ionic oxatriazoles were investigated as sources of free radicals. Mono-substituted tetrazolinones decomposed at their melting points. Nitrosation and nitration of the tetrazolinone ring was unsuccessful, although alkoxyalkylation of the ring took place in ether in the presence of nitrosomium and nitronium tetrafluoroborate. The tetrazolinone ring was photolytically unstable, and both eliminated nitrogen and cycloreverted. γ-irradiation of the naphthyl deivative caused cleavage of the nitrogen-hydrogen bond to give a radical which was identified by
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15

Brookman, Charles Alexander. "The molecular structures of some heterocyclic compounds." Thesis, University of Edinburgh, 1993. http://hdl.handle.net/1842/12791.

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The gas-phase molecular structures of 2-chloropyridine, 3-chloropyridine, 4-chloropyridine, chloropyrazine, 1,2,3-triazine, 1,3,5-triazine and 1,2,4,5-tetrazine have been determined by electron differaction, and, in the case of the first two and the fourth, by combining them with microwave spectoscopy data. Of particular interest was the combination of ring distortion effects arising from both the chlorine substituent and the nitrogen heteratom. The results tend to indicate a more complicated system than that of purely substituent effects, an area already well documented. One of the interestin
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16

Ohshiro, Takashi. "MICROBIAL SULFUR METABOLISM OF HETEROCYCLIC SULFUR COMPOUNDS." Kyoto University, 1996. http://hdl.handle.net/2433/78073.

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17

Taylor, Lynne M. "Interactions of platinum compounds with heterocyclic bases." Thesis, Robert Gordon University, 1990. http://hdl.handle.net/10059/2356.

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It is generally accepted that platinum antitumour drugs bind, preferentially, to Guanine N7 in DNA. Thus the kinetics of formation and the energetics of dissociation of platinum-nitrogen bonding have been investigated, using simple model bases, namely pyridine. pyrimidine. purine and some derivatives. Six complexes of the type cis-PtCl2L2, where L is a N-heterocycle, have been successfully prepared and characterized. The kinetics of the reaction between K2PtCl4 and the N-heterocyclic bases in aqueous solution have beeD studied. This was best achieved by pre-aquating the PtCl4(2-) and measuring
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18

Lewis, William. "Chiral Heterocyclic Ligands." Thesis, University of Canterbury. Chemistry, 2007. http://hdl.handle.net/10092/1383.

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This thesis describes the preparation and characterisation of a number of homochiral coordination and metallosupramolecular assemblies. These species were formed from the reaction of chiral pyridine and quinoline containing ligands and metal ions. The combination of traditional coordination chemistry and supramolecular interactions led to a range of polymeric and network structures being formed. The ligands used in this thesis can be divided into two broad categories: alkaloids and ligands derived from them, and amino acid-based ligands. In the first category three new ligands were synthesi
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19

Layman, William Joseph. "The SRN1 reactivity of halobenzenesulfonamides and related compounds." Diss., This resource online, 1990. http://scholar.lib.vt.edu/theses/available/etd-08252008-162626/.

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20

Emans, John. "Synthesis of novel heterocyclic polymers." Thesis, University of St Andrews, 1987. http://hdl.handle.net/10023/15299.

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This work details the synthesis, characterisation and fabrication of a range of copolyesters, containing various angular disrupters, especially disubstituted 2,5-diphenyl- -1,3,4-oxadiazoles. These disrupters were incorporated into the polymers, to reduce the temperature at which the polymers may be processed, to enable their fabrication into fibres. The majority of the polymers prepared were found to be liquid crystalline. However, if the angular disrupter content of the polymer was high, it was found that the resultant polymers were non-liquid crystalline. The polymers were prepared by a mel
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21

Khan, Musharraf Naveed. "Synthesis of different heterocyclic compounds of pharmaceutical relevance." Thesis, University of Huddersfield, 2013. http://eprints.hud.ac.uk/id/eprint/19503/.

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This thesis describes the synthesis of different cyclic imines and the exploration of their reactivity with cyclopropenones and 1,3-dipoles,as well as an investigation of the chemistry of the products. The synthesis of biologically and pharmaceutically important heterocyclic natural product analogues, such as the pyrroloazepines, indolizidines and pyrrolizidines has been achieved using a cycloaddition reaction between cyclic imidates and cyclopropenones. A new route to pyridines has been developed using the generation of a proposed 3-azacyclopentadienone as the key step. The 3-azacyclopentadie
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22

Stewart, Lesley Ann. "Synthesis of heterocyclic compounds as potential anticancer agents." Thesis, University of Glasgow, 1996. http://theses.gla.ac.uk/4936/.

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23

Philbin, Simon Patrick. "Studies of novel nitro-substituted nitrogen heterocyclic compounds." Thesis, Brunel University, 2001. http://bura.brunel.ac.uk/handle/2438/2165.

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The novel candidate high energy insensitive explosive; 2,5-diamino-3,6-dinitropyrazine (ANPZ-i) has been prepared in acceptable overall yield. ANPZ-i was synthesised by the nitration of 2,5-diethoxypyrazine using nitronium tetrafluoroborate (NO2+BF4-) in sulfolane and the subsequent amination of 2,5-diethoxy-3,6-dinitropyrazine, under autoclave conditions. Oxidation studies towards the dioxide derivative of ANPZ-i, 2,5-diamino-3,6-dinitropyrazine-1,4-dioxide (PZDO), were unsuccessful. The synthesis of existing high explosives; 2,6-diamino-3,5-dintropyrazine (ANPZ) and 2,6-diamino-3,5-dinitropy
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24

Al-Suwaidan, I. A. "Heterocyclic compounds as novel substrates for glutathione transferase." Thesis, University of Bradford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378114.

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25

Black, Helen Dinah. "Kinetics of hydroxyl radical reactions with heterocyclic compounds." Thesis, University of Leeds, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.305373.

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26

Fallah, Asadollah. "Stereochemistry and reactivity of some 1,3-heterocyclic compounds." Thesis, University of Portsmouth, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328185.

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27

Mojally, Mariam. "DNA binding studies of fluorinated bioactive heterocyclic compounds." Thesis, Loughborough University, 2015. https://dspace.lboro.ac.uk/2134/16732.

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Fluorinated heterocyclic compounds have drug like properties and possess a valuable biological activity due to their rigid chemical structures and the high solubility profile. Novel fluorinated heteroarenes have been synthesised by SNAr reaction of a range of fluorinated arenes including pentafluoropyridine, hexafluorobenzene and pentafluorotoluene to introduce a range of groups specially nitriles, benzimidazole, carbazole and benzimidazole. A number of cyclization reactions have been investigated with the aim of forming polycyclic structures that could act as DNA intercalators. The synthesise
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28

Gavryliuk, O. I. "Heterocyclic compounds as the basis of medical drugs." Thesis, БДМУ, 2022. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/19711.

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29

Robinson, William J. III. "Development of Tetrathiafulvalene Fused N-Heterocyclic Carbene Compounds." Wright State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=wright1610382201476554.

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30

Taher, Abutariq. "Novel cyclisations of nitro-compounds for heterocyclic synthesis." Thesis, Loughborough University, 2001. https://dspace.lboro.ac.uk/2134/34705.

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The research described in this thesis is aimed at developing novel methods of synthesis for heterocyclic compounds, in particular cyclisation reactions involving the nitro functional group. The first chapter describes investigations into the Wallach imidazole synthesis. A number of chloroimidazoles were prepared, but the possible extension to highly functionalised imidazoles proved elusive. The second chapter describes studies on the successful conversion of nitroimidazolyl malonates 1 into imidazo[4,5-c]isoxazoles 2, Scheme 1. Related cyclisations are described in chapter three and the thioph
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31

Venkatraman, M. S. "Synthetic studies towards camptothecin and other heterocyclic compounds." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1997. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3278.

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32

Leu, Chao-Wei Chemistry Faculty of Science UNSW. "Synthesis of heterocyclic analogues of phytoestrogens." Publisher:University of New South Wales. Chemistry, 2008. http://handle.unsw.edu.au/1959.4/40824.

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The pyrrolo[3,2,1-ij]quinolin-6-one ring system was synthesised from 3-aryl-4,6-dimethoxyindoles and 2,3-disubstituted-4,6-dimethoxyindoles. The reaction of 4,6-dimethoxyindoles under Friedel-Crafts or Vilsmeier-Haack acylation gave the 2- and 7-indolyldeoxybenzoins in good yield. Cyclisation of 7-indolyldeoxybenzoins with N,N-dimethylformamide dimethyl acetal as a one carbon reagent gave the pyrroloquinolin-6-ones in high yield. Reduction of pyrroloquinolin-6-ones with hydrogen gas and 10% palladium on carbon or lithium aluminium hydride yielded the dihydropyrroloquinolin-6-ones. Demethylatio
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33

Orton, Edward. "Synthesis and chemistry of 4,5-dimethylene-1,3-dioxolan-2-one and related compounds /." Thesis, Connect to this title online; UW restricted, 1985. http://hdl.handle.net/1773/8620.

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34

Nchinda, Aloysius Tchangwe. "Chemical studies of selected chromone derivatives." Thesis, Rhodes University, 2002. http://hdl.handle.net/10962/d1007442.

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This investigation has been geared towards several aspects of chromone chemistry. Selected 2-(N,N-dimethylarnino)chromones have been synthesized via 2-hydroxyacetophenone boron difluoride complex intermediates, and potentiometric analysis of these compounds in ethanolwater has been used to determine the influence of substituents on their basicity. The pKa values have been found to lie within a narrow range (1.92 - 2.52), and the observed substituent effects have been rationalized with the aid of semi-empirical and ab initio molecular orbital calculations. An efficient route has been developed
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35

Rogers, James William. "1-benzotriazolyl-2-propynones as novel 1,3-biselectrophiles, benzotriazole-assisted thioacylation and synthesis of energetic materials." [Gainesville, Fla.] : University of Florida, 2006. http://purl.fcla.edu/fcla/etd/UFE0013389.

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36

Cai, Chunming. "Microwave mediated synthesis of nitrogen- and/or oxygen-containing compounds." [Gainesville, Fla.] : University of Florida, 2006. http://purl.fcla.edu/fcla/etd/UFE0013762.

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37

Brown, Eric Carroll. "Computational studies on the effects of heteroatom substitution in delocalized pi systems /." Thesis, Connect to this title online; UW restricted, 2002. http://hdl.handle.net/1773/8558.

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38

Ganto, Mlungiseleli MacDonald. "Application of Baylis-Hillman methodology in the construction of complex heterocyclic targets." Thesis, Rhodes University, 2009. http://hdl.handle.net/10962/d1006703.

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Baylis-Hillman reactions using various aromatic aldehydes, activated alkenes and catalysts have been used to: - access an extensive range of poly-heterocyclic products;explore chemoselectivity; and optimise reaction efficiency. Chromone-3-carbaldehydes and chromone-2-carbaldehydes, prepared via Vielsmeier-Haack and Kostanecki-Robinson methodology, respectively, have been used as Baylis-Hillman substrates with four different catalysts, viz., 1,4-diazabicyclo[2.2.2]octane (DABCO), 3-hydroxyquinuclidine (3-HQ), imidazole and N’,N’,N’,N’- tetramethylpropanediamine (TMPDA), and with methyl vinyl ke
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39

Nocanda, Xolani Wittleton. "Applications of Baylis-Idllman methodology in the synthesis of chromene derivatives." Thesis, Rhodes University, 2001. http://hdl.handle.net/10962/d1018257.

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The reaction of salicylaldehyde with various activated alkenes, viz., methyl vinyl ketone, ethyl vinyl ketone, phenyl vinyl sulfone, phenyl vinylsulfonate, acrolein and acrylonitrile, under Baylis-Hillman conditions, has been found to proceed with the chemoselective formation of chromene derivatives. The reaction conditions have been optimised and chromene derivatives have been obtained in isolated yields up to 87 %. The generality of the reaction, using 1,4-diazabicyclo[2.2.2]octane (DABCO), as the catalyst, and a heterogeneous (chloroform-water) solvent system, has been established using a r
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40

Cow, Christopher N. "Orchestration of reactions on glycoluril templates /." *McMaster only, 1997.

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41

李安怡 and On-yi Lee. "Synthesis of heterocycles via phenylseleno group transfer radical cyclization and chemoselective reductive amination promoted by InCl3." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B3955756X.

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42

Zinser, Caroline Magdalene. "Palladium and gold N-heterocyclic carbene complexes : synthesis and catalytic applications." Thesis, University of St Andrews, 2019. http://hdl.handle.net/10023/17066.

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43

Johansson, Maria. "Influence of lipids and pro- and antioxidants on the yield of carcinogenic heterocyclic amines in cooked foods and model systems." Lund, Sweden : Dept. of Applied Nutrition and Food Chemistry, Lund Institute of Technology, Lund University, 1995. http://catalog.hathitrust.org/api/volumes/oclc/38206526.html.

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44

Dupuy, Stéphanie. "N-heterocyclic carbene gold hydroxide complexes as bond activation reagents." Thesis, University of St Andrews, 2014. http://hdl.handle.net/10023/6613.

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Although known since the 1930s, organogold chemistry has been dormant until recently, primarily due to preconceptions about the inertness of gold in transformations. However, this last decade has witnessed the emergence of a Golden Age with the development of a wealth of reports on gold in a plethora of reactions. In recent years, the drive for more atom- and step-economical and environmentally friendly reactions has become a field of intense research. In our on-going research on well-defined transition metal complexes bearing NHC ligands, our group recently discovered a new gold(I) hydroxide
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45

區逸貫 and Yat-kun Au. "Chemical reactivities of triosmium carbonyl clusters with nitrogen heterocycles and organomercurials." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1996. http://hub.hku.hk/bib/B31234604.

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46

Au, Yat-kun. "Chemical reactivities of triosmium carbonyl clusters with nitrogen heterocycles and organomercurials /." Hong Kong : University of Hong Kong, 1996. http://sunzi.lib.hku.hk/hkuto/record.jsp?B17490340.

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47

Fletcher, Kristin A. "Mobile Order Theory as Applied to Polycyclic Aromatic Heterocycles." Thesis, University of North Texas, 1997. https://digital.library.unt.edu/ark:/67531/metadc278994/.

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Experimental mole fraction solubilities of benzil, thianthrene, trans-stilbene, thioxanthen-9-one, diphenyl sulfone and dibenzothiophene sulfone are determined in pure noncomplexing and complexing solvents. Predicted solubility values are calculated for benzil, thianthrene, trans-stilbene and thioxanthen-9-one using expressions derived from Mobile Order theory. Large deviations between experimental and predicted solubilities in alcohol solvents exist, therefore optimized solute - solvent association constants are determined. Previously measured thianthrene solubilities in five binary alkane +
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48

Burnett, Duane Arthur. "Synthesis of nitrogen containing heterocycles /." The Ohio State University, 1986. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487264603219377.

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49

Laserna, Ayora Victor. "Small Molecule Activation for the Formation of Heterocyclic Compounds." Doctoral thesis, Universitat Rovira i Virgili, 2017. http://hdl.handle.net/10803/457704.

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La tesi se centra en l'activitat dels aminotrifenolatos d'alumini en l'activació de epòxids i la seva posterior acoblament a altres molècules en la formació de diferents heterocicles. El catalitzador és un àcid de Lewis que en interaccionar amb el epòxid augmenta la electrofilia d'aquest, afavorint processos d'obertura de cicle i acoblament a heterocumulenos com el CO2 o el SO2. Hem aconseguit descriure metodologies per a la síntesi de oxazolidinones, carbamats, sulfits cíclics o carbonats cíclics. Molts d'aquests processos ja havien estat descrits amb anterioritat per epòxids terminals, per a
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50

Berlin, Stefan. "Construction of Five-Membered Heterocyclic Compounds via Radical Cyclization." Doctoral thesis, Uppsala University, Department of Chemistry, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3429.

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<p>This thesis describes how radical cyclization chemistry can be applied for the construction of heterocyclic compounds.</p><p>In the first part, a series of electron deficient α-phenylselenenylalkenes were prepared <i>via</i> a PhSeCl-addition/HCl-elimination sequence. Allyl- and propargylamines readily underwent conjugate addition to these species to produce pyrrolidines or dihydropyrrol derivatives, after triethylborane initiated reductive radical cyclization in the presence of tris(trimethylsilyl)silane.</p><p>The second part describes a convergent synthesis of the pineal hormone melatoni
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