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Thematische Bibliographien / Histamine H2 receptor antagonist / Zeitschriftenartikel

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Zeitschriftenartikel zum Thema „Histamine H2 receptor antagonist“

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Veröffentlicht am 7. Juni 2025

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1

Chen, M., and L. A. Brown. "Histamine stimulation of surfactant secretion from rat type II pneumocytes." American Journal of Physiology-Lung Cellular and Molecular Physiology 258, no. 4 (1990): L195—L200. http://dx.doi.org/10.1152/ajplung.1990.258.4.l195.

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The present study examined the effect of histamine on the secretion of phosphatidylcholine, the predominant component of pulmonary surfactant from adult rat alveolar type II pneumocytes in primary culture. Histamine stimulated surfactant secretion in a time- and dose-dependent manner. At a concentration of 10 microM, histamine stimulated surfactant release by 5.2-fold over the basal secretory rate. The concentration producing half the maximal response for histamine-induced secretion was 70 nM. Histamine-induced secretion was blocked by both the selective histamine1 receptor antagonist pyrilami

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2

Neely, C. F., I. Matot, D. Haile, J. Nguyen, and V. Batra. "Tone-dependent responses of histamine in feline pulmonary vascular bed." American Journal of Physiology-Heart and Circulatory Physiology 268, no. 2 (1995): H653—H661. http://dx.doi.org/10.1152/ajpheart.1995.268.2.h653.

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Under conditions of controlled pulmonary blood flow and constant left atrial pressure, histamine produced tone-dependent responses in the pulmonary vascular (PV) bed of intact-chest, spontaneously breathing cats. At low, baseline PV tone, histamine produced dose-dependent increases in mean lobar arterial pressure that were antagonized by the selective histamine H1-receptor antagonist, diphenhydramine. The cyclooxygenase inhibitor, meclofenamate, and the thromboxane A2 (TxA2) receptor antagonist, SQ-29548, had no effect on these vasoconstrictor responses of histamine. After an increase in PV to

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3

Baloch, Naseer Khan, Nusrat Jafri, and Ahmed Danyal. "H2 RECEPTOR ACTIVITY." Professional Medical Journal 21, no. 05 (2018): 933–35. http://dx.doi.org/10.29309/tpmj/2014.21.05.2499.

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… Histamine can stimulate the heart by directly interacting with cardiac histaminereceptors. In the present study we have investigated the H2 receptor activity in isolated rabbitheart. Cimetidine, a specific H2 receptor antagonist was used. The isolated heart was mountedin langendroff apparatus. The heart was perfused at a constant pressure with oxygenatedRinger‘s Locke solution. H2 receptor antagonist produces negative inotropic effect in thepresence of histamine. This indicates that H2 receptors are present in rabbit heart, and plays arole in mediation of positive inotropic effect produced t

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Champion, Hunter C., Trinity J. Bivalacqua, David G. Lambert, Rasheed A. Abassi, and Philip J. Kadowitz. "Analysis of vasoconstrictor responses to histamine in the hindlimb vascular bed of the rabbit." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 277, no. 4 (1999): R1179—R1187. http://dx.doi.org/10.1152/ajpregu.1999.277.4.r1179.

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Hemodynamic responses to histamine were investigated in the anesthetized rabbit. Intravenous injections of histamine induced dose-dependent decreases in systemic arterial pressure that were blocked by the H1-receptor antagonist pyrilamine but not the H2 antagonist cimetidine. Injections of histamine and the H1 agonist 6-[2-(4-imidazolyl)ethylamine]- N-(4-trifuormethylphenyl)-heptanecardoxamide dimaleate (HTMT) into the hindlimb perfusion circuit increased hindlimb perfusion pressure, whereas the H2agonist dimaprit decreased perfusion pressure and the H3-receptor agonist R-(−)-α-methylhistamine

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5

Barman, S. A., and A. E. Taylor. "Histamine's effect on pulmonary vascular resistance and compliance at elevated tone." American Journal of Physiology-Heart and Circulatory Physiology 257, no. 2 (1989): H618—H625. http://dx.doi.org/10.1152/ajpheart.1989.257.2.h618.

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Histamine's effect on the longitudinal resistance and compliance distribution in the canine pulmonary circulation was determined under control and elevated vascular tone using the thromboxane analogue U46619. The arterial-, venous-, and double-occlusion techniques were used in isolated blood-perfused dog lungs at both constant flow and constant pressure. Large and small blood vessel resistances and compliances were studied in lungs given the following treatments: 1) histamine; 2) histamine in lungs pretreated with the H1-receptor antagonist diphenhydramine, and 3) histamine in lungs pretreated

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Ahmed, T., and M. King. "Suppression of pulmonary and systemic vascular histamine H2-receptors in allergic sheep." Journal of Applied Physiology 60, no. 3 (1986): 791–97. http://dx.doi.org/10.1152/jappl.1986.60.3.791.

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We have previously demonstrated a depression of airway H2-receptor function in sheep allergic to Ascaris suum antigen. To investigate whether this is a generalized defect, we studied the H1- and H2- histamine receptor functions in the pulmonary and systemic circulations of allergic and nonallergic sheep. Pulmonary arterial pressure, and cardiac output were measured for calculation of pulmonary vascular resistance (PVR) and systemic vascular resistance (SVR) before and immediately after a rapid intrapulmonary infusion of histamine (10 micrograms/kg), with and without pretreatment with H1- (chlo

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7

Mahjour, Marjan, and Arash Khoushabi. "An Herbal H2 Blocker in Melasma Treatment." Current Drug Discovery Technologies 17, no. 3 (2020): 272–77. http://dx.doi.org/10.2174/1570163816666190121145653.

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Background: Melasma is a skin pigmentation disorder that remains resistant to available therapies. The exact cause of melasma is unknown. Histamine is an inflammatory factor. Its involvement in pigmentation is obscure. The aim of this study is to introduce an herbal antihistamine H2 receptor which is effective in these disorders. Methods: This is a review study by searching the electronic databases and also Persian Medicine books, from 2000 to 2018 by the keywords such as H2 antagonist, H2 blocker and melasma. Results: According to the researched studies, histamine can induce melanogenesis and

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Knigge, Ulrich, Steen Matzen, and Jørgen Warberg. "Effects of H2-receptor antagonists on prolactin secretion: Specificity and mediation of the response." Acta Endocrinologica 115, no. 4 (1987): 461–68. http://dx.doi.org/10.1530/acta.0.1150461.

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Abstract. The effects on prolactin secretion of histamine H2-receptor antagonists infused intracerebroventricularly were studied in urethane anaesthetized male rats. A dose of 1.6 μmol cimetidine stimulated basal prolactin secretion and did not affect the histamine-induced release, whereas 0.4 μmol cimetidine inhibited basal and histamine-stimulated prolactin secretion. 0.1 μmol cimetidine had no effect. The more potent H2-receptor antagonist ranitidine at doses of 0.1, 0.4, 1.6 μmol had no effect on basal prolactin secretion, whereas 0.4 and 1.6 μmol inhibited the histamine-stimulated secreti

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9

Taylor, D. J., J. R. Yoffe, D. M. Brown, and D. E. Woolley. "Histamine H2 receptors on chondrocytes derived from human, canine and bovine articular cartilage." Biochemical Journal 225, no. 2 (1985): 315–19. http://dx.doi.org/10.1042/bj2250315.

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Histamine (1-100 microM) induced a concentration-dependent increase in intracellular cyclic AMP in monolayer cultures of human, canine and foetal-bovine articular chondrocytes. The dose-response curve for histamine in each culture was progressively displaced to the right with increasing concentrations of cimetidine, an H2-receptor antagonist. The histamine-induced cyclic AMP elevation in human articular chondrocytes was also significantly decreased by ranitidine, another H2 antagonist, but not by the H1 antagonists mepyramine and chlorpheniramine. These findings indicate that histamine activat

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Whyment, Andrew D., Andrew M. Blanks, Kevin Lee, Leo P. Renaud, and David Spanswick. "Histamine Excites Neonatal Rat Sympathetic Preganglionic Neurons In Vitro Via Activation of H1 Receptors." Journal of Neurophysiology 95, no. 4 (2006): 2492–500. http://dx.doi.org/10.1152/jn.01135.2004.

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The role of histamine in regulating excitability of sympathetic preganglionic neurons (SPNs) and the expression of histamine receptor mRNA in SPNs was investigated using whole-cell patch-clamp electrophysiological recording techniques combined with single-cell reverse transcriptase polymerase chain reaction (RT-PCR) in transverse neonatal rat spinal cord slices. Bath application of histamine (100 μM) or the H1 receptor agonist histamine trifluoromethyl toluidide dimaleate (HTMT; 10 μM) induced membrane depolarization associated with a decrease in membrane conductance in the majority (70%) of S

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Knigge, Ulrich, Steen Matzen, Flemming W. Bach, Peter Bang, and Jørgen Warberg. "Involvement of histaminergic neurons in the stress-induced release of pro-opiomelanocortin-derived peptides in rats." Acta Endocrinologica 120, no. 4 (1989): 533–39. http://dx.doi.org/10.1530/acta.0.1200533.

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Abstract. Histamine, which acts as a neurotransmitter, stimulates the release of the pro-opiomelanocortin derived peptides ACTH, β-lipotropin, and β-endorphin. Since stress affects the hypothalamic turn-over of neuronal histamine, we investigated the role of histaminergic neurons in the mediation of the stress-induced release of ACTH and β-endorphin immunoreactivity in male rats. In control animals histamine receptor antagonists had no effect on the release of ACTH or β-endorphin immunoreactivity. Restraint and ether stress increased plasma ACTH 3- and 2-fold, respectively. The responses were

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Knigge, Ulrich, Flemming W. Bach, Steen Matzen, Peter Bang, and Jørgen Warberg. "Effect of histamine on the secretion of pro-opiomelanocortin derived peptides in rats." Acta Endocrinologica 119, no. 2 (1988): 312–19. http://dx.doi.org/10.1530/acta.0.1190312.

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Abstract. In conscious male rats intracerebroventricular infusion of histamine increased the plasma concentrations of ACTH and β-endorphin immunoreactivity 2.5-fold (P < 0.01). Gel filtration of plasma revealed two peaks of β-endorphin immunoreactivity corresponding to β-endorphin and β-lipotropin. The two fractions increased almost equally in histamine-stimulated animals, whereas most of the circulating β-endorphin immunoreactivity in control animals corresponded to β-endorphin. Central infusion of the H1-receptor agonist 2-thiazolylethylamine and of the H2-receptor agonists dimaprit or 4-

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Jacob, Hannes, Pauline Braekow, Rebecca Schwarz, et al. "Ergotamine Stimulates Human 5-HT4-Serotonin Receptors and Human H2-Histamine Receptors in the Heart." International Journal of Molecular Sciences 24, no. 5 (2023): 4749. http://dx.doi.org/10.3390/ijms24054749.

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Ergotamine (2′-methyl-5′α-benzyl-12′-hydroxy-3′,6′,18-trioxoergotaman) is a tryptamine-related alkaloid from the fungus Claviceps purpurea. Ergotamine is used to treat migraine. Ergotamine can bind to and activate several types of 5-HT1-serotonin receptors. Based on the structural formula of ergotamine, we hypothesized that ergotamine might stimulate 5-HT4-serotonin receptors or H2-histamine receptors in the human heart. We observed that ergotamine exerted concentration- and time-dependent positive inotropic effects in isolated left atrial preparations in H2-TG (mouse which exhibits cardiac-sp

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14

Starodub, Alexander M., and Jackie D. Wood. "Histamine H2 Receptor Activated Chloride Conductance in Myenteric Neurons From Guinea Pig Small Intestine." Journal of Neurophysiology 83, no. 4 (2000): 1809–16. http://dx.doi.org/10.1152/jn.2000.83.4.1809.

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Whole cell perforated patch-clamp methods were used to investigate ionic mechanisms underlying histamine-evoked excitatory responses in small intestinal AH-type myenteric neurons. When physiological concentrations of Na+, Ca2+, and Cl− were in the bathing medium, application of histamine significantly increased total conductance as determined by stepping to 50 mV from a holding potential of −30 mV. The current reversed at a membrane potential of −30 ± 5 (SE) mV and current-voltage relations exhibited outward rectification. The reversal potential for the histamine-activated current was unchange

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Champion, H. C., and P. J. Kadowitz. "NO release and the opening of K+ATP channels mediate vasodilator responses to histamine in the cat." American Journal of Physiology-Heart and Circulatory Physiology 273, no. 2 (1997): H928—H937. http://dx.doi.org/10.1152/ajpheart.1997.273.2.h928.

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Responses to histamine were investigated in the hindlimb vascular bed of the cat under constant-flow conditions. Injections of histamine, the H1 agonist HTMT, the H2 agonist dimaprit, and the H3 agonist R(-)-alpha-methylhistamine caused dose-related decreases in hindlimb perfusion pressure. Pyrilamine reduced the responses to histamine and HTMT by approximately 80%, whereas cimetidine reduced the responses to histamine by 20% and to dimaprit by approximately 50%. The H3-receptor antagonist thioperamide reduced the responses to R(-)-alpha-methylhistamine by approximately 60% but was without eff

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Fukagawa, K., T. Sakata, T. Shiraishi, et al. "Neuronal histamine modulates feeding behavior through H1-receptor in rat hypothalamus." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 256, no. 3 (1989): R605—R611. http://dx.doi.org/10.1152/ajpregu.1989.256.3.r605.

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To clarify the physiological role of hypothalamic neuronal histamine in control of food intake, ingestive behavior and neuronal activity were investigated under blockade or diurnal fluctuation of hypothalamic neuronal histamine. Histamine H1- but not H2-receptor antagonist potently induced feeding in a dose-related manner after infusion into rat third cerebroventricle at 1100 h. Elicitation was attenuated after infusion at 1940 h when histamine content in the hypothalamus was low and was abolished after intraperitoneal pretreatment with 0.11 mmol alpha-fluoromethylhistidine (alpha-FMH), a spec

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17

Long, W. M., C. L. Sprung, H. el Fawal, et al. "Effects of histamine on bronchial artery blood flow and bronchomotor tone." Journal of Applied Physiology 59, no. 1 (1985): 254–61. http://dx.doi.org/10.1152/jappl.1985.59.1.254.

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The effects of aerosolized 5% histamine (10 breaths) on bronchial artery blood flow (Qbr), airflow resistance (RL), and pulmonary and systemic hemodynamics were studied in mechanically ventilated sheep anesthetized with pentobarbital sodium. Histamine increased mean Qbr and RL to 252 +/- 45 and 337 +/- 53% of base line, respectively. This effect was significantly different from base line for 30 min after challenge. The histamine-induced increase in RL was blocked by pretreatment with the histamine H1 receptor antagonist, chlorpheniramine, whereas the histamine-induced elevation in Qbr was prev

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18

Parsons, G. H., A. C. Villablanca, J. M. Brock, et al. "Bronchial vasodilation by histamine in sheep: characterization of receptor subtype." Journal of Applied Physiology 72, no. 6 (1992): 2090–98. http://dx.doi.org/10.1152/jappl.1992.72.6.2090.

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Histamine has been shown to mediate features of pulmonary allergic reactions including increased tracheobronchial blood flow. To determine whether the increase in blood flow was due to stimulation of H1- or H2-histamine receptors, we gave histamine base (0.1 micrograms/kg iv) or histamine dihydrochloride as an aerosol (10 breaths of 0.5% “low dose” or 5% “high dose”) before and after H1- or H2-receptor antagonists. Blood velocity in the common bronchial branch of the bronchoesophageal artery (Vbr) was continuously measured using a chronically implanted Doppler flow probe. Pretreatment with H2-

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Leth, R., B. Elander, U. Haglund, L. Olbe, and E. Fellenius. "Histamine H2-receptor of human and rabbit parietal cells." American Journal of Physiology-Gastrointestinal and Liver Physiology 253, no. 4 (1987): G497—G501. http://dx.doi.org/10.1152/ajpgi.1987.253.4.g497.

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The histamine H2-receptor on the human parietal cell has been characterized by using dose-response curves and the negative logarithm of the molar concentration of an antagonist (pA2) analyses of cimetidine antagonism of betazole, histamine, and impromidine stimulation in isolated human and rabbit gastric glands. To evaluate the in vitro results, betazole-stimulated gastric acid secretion with and without cimetidine was also studied in healthy subjects. In the in vivo model, individual dose-response curves were shifted to the right with increasing cimetidine concentrations, but this was counter

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Gespach, C., S. Emami, E. Chastre, J. M. Launay, and G. Rosselin. "Up- and down-regulation of membrane receptors as possible mechanisms related to the antiulcer actions of milk in rat gastric mucosa." Bioscience Reports 7, no. 2 (1987): 135–42. http://dx.doi.org/10.1007/bf01121877.

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The effects of a cow's milk diet on receptor activity and histamine metabolism in gastric glands and mucosa isolated from adult rats were examined. The milk diet was associated with (1) a decreased mobilization of H2 receptors by histamine and (2) an increased mobilization of PGE2 (prostaglandin E2) receptors in mucous cells (cytoprotective effect) and parietal cells (antiacid effect). These changes are not observed for the receptors reducing pentagastrin- and histamine-induced gastric acid secretion (pancreatic/enteroglucagons, somatostatin) and stimulating mucus, bicarbonate and pepsin secre

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Hollande, F., J. P. Bali, and R. Magous. "Autoregulation of histamine synthesis through H3 receptors in isolated fundic mucosal cells." American Journal of Physiology-Gastrointestinal and Liver Physiology 265, no. 6 (1993): G1039—G1044. http://dx.doi.org/10.1152/ajpgi.1993.265.6.g1039.

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Histamine plays an important role in the control of gastric acid secretion by activating H2 receptors located on parietal cells. In gastric mucosa, histamine is stored both in mast cells and in enterochromaffin-like cells, especially in rodents. It has been proposed that histamine may regulate its own synthesis and/or release through receptors pharmacologically distinct from H1- and H2-receptor subtypes. In this article, we studied the regulation by histamine of histidine decarboxylase (HDC) activity (enzyme responsible for the formation of histamine by decarboxylation of L-histidine) in a fra

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Kjær, Andreas, Ulrich Knigge, Henrik Jørgensen, and Jørgen Warberg. "Dehydration-induced vasopressin secretion in humans: involvement of the histaminergic system." American Journal of Physiology-Endocrinology and Metabolism 279, no. 6 (2000): E1305—E1310. http://dx.doi.org/10.1152/ajpendo.2000.279.6.e1305.

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In rats, the hypothalamic neurotransmitter histamine participates in regulation of vasopressin secretion and seems to be of physiological importance, because blockade of the histaminergic system reduces dehydration-induced vasopressin secretion. We investigated whether histamine is also involved in regulation of vasopressin secretion during dehydration in humans. We found that 40 h of dehydration gradually increased plasma osmolality by 10 mosmol/kg and induced a fourfold increase in vasopressin levels. Pretreatment with the H2-receptor antagonists cimetidine or ranitidine significantly reduce

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Bozarov, Andrey, Yu-Zhong Wang, Jun Ge Yu, et al. "Activation of adenosine low-affinity A3 receptors inhibits the enteric short interplexus neural circuit triggered by histamine." American Journal of Physiology-Gastrointestinal and Liver Physiology 297, no. 6 (2009): G1147—G1162. http://dx.doi.org/10.1152/ajpgi.00295.2009.

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We tested the novel hypothesis that endogenous adenosine (eADO) activates low-affinity A3 receptors in a model of neurogenic diarrhea in the guinea pig colon. Dimaprit activation of H2 receptors was used to trigger a cyclic coordinated response of contraction and Cl− secretion. Contraction-relaxation was monitored by sonomicrometry (via intracrystal distance) simultaneously with short-circuit current ( Isc, Cl− secretion). The short interplexus reflex coordinated response was attenuated or abolished by antagonists at H2 (cimetidine), 5-hydroxytryptamine 4 receptor (RS39604), neurokinin-1 recep

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Desautels, M., A. Wollin, I. Halvorson, D. V. Muralidhara, and J. Thornhill. "Role of mast cell histamine in brown adipose tissue thermogenic response to VMH stimulation." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 266, no. 3 (1994): R831—R837. http://dx.doi.org/10.1152/ajpregu.1994.266.3.r831.

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Electrical stimulation of the ventromedial hypothalamic area in rats caused a significant but transient increase in interscapular brown adipose tissue temperature. This response was markedly reduced by cimetidine, a histamine H2-receptor antagonist, but not by pyrilamine, an H1-receptor antagonist. Histamine is present in substantial amounts within mast cells in brown adipose tissue as injections of compound 48/80, which cause degranulation of connective tissue mast cells, reduced the tissue histamine content by > 85%. In contrast, histamine content in brown adipose tissue was not affected

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Koda, H., M. Minagawa, L. Si-Hong, K. Mizumura, and T. Kumazawa. "H1-receptor-mediated excitation and facilitation of the heat response by histamine in canine visceral polymodal receptors studied in vitro." Journal of Neurophysiology 76, no. 3 (1996): 1396–404. http://dx.doi.org/10.1152/jn.1996.76.3.1396.

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1. We examined excitation and the facilitatory effect on the heat responses induced by histamine in visceral polymodal receptors with the use of the canine testis-spermatic nerve preparation in vitro. 2. The proportion of units that showed excitation (> 10 impulses 1 min after application of histamine was initiated) increased roughly with higher concentrations of histamine: 7% at 1 microM, 26% at 10 microM, 79% at 100 microM, and 61% at 1,000 microM. The discharge rate also increased with the concentration. 3. Histamine (100 and 1,000 microM) responses > 0.5 imp/s were observed only in u

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Zhang, David X., Kathryn M. Gauthier, and William B. Campbell. "Mechanisms of histamine-induced relaxation in bovine small adrenal cortical arteries." American Journal of Physiology-Endocrinology and Metabolism 289, no. 6 (2005): E1058—E1063. http://dx.doi.org/10.1152/ajpendo.00162.2005.

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Adrenal steroidogenesis is closely correlated with increases in adrenal blood flow. Many reports have studied the regulation of adrenal blood flow in vivo and in perfused glands, but until recently few studies have been conducted on isolated adrenal arteries. The present study examined vasomotor responses of isolated bovine small adrenal cortical arteries to histamine, an endogenous vasoactive compound, and its mechanism of action. In U-46619-precontracted arteries, histamine (10−9-5 × 10−6 M) elicited concentration-dependent relaxations. The relaxations were blocked by the H1 receptor antagon

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Wong, Brett J., Sarah J. Williams, and Christopher T. Minson. "Minimal role for H1 and H2 histamine receptors in cutaneous thermal hyperemia to local heating in humans." Journal of Applied Physiology 100, no. 2 (2006): 535–40. http://dx.doi.org/10.1152/japplphysiol.00902.2005.

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The precise mechanism(s) underlying the thermal hyperemic response to local heating of human skin are not fully understood. The purpose of this study was to investigate a potential role for H1 and H2 histamine-receptor activation in this response. Two groups of six subjects participated in two separate protocols and were instrumented with three microdialysis fibers on the ventral forearm. In both protocols, sites were randomly assigned to receive one of three treatments. In protocol 1, sites received 1) 500 μM pyrilamine maleate (H1-receptor antagonist), 2) 10 mM l-NAME to inhibit nitric oxide

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Ulloa, E. R., and A. A. Zaninovich. "Effects of histamine H1- and H2-receptor antagonists on thyrotrophin secretion in the rat." Journal of Endocrinology 111, no. 1 (1986): 175–80. http://dx.doi.org/10.1677/joe.0.1110175.

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ABSTRACT The effects of histamine H1- and H2-receptor antagonists on the pituitary-thyroid axis were studied in normal and thyroxine (T4)-treated rats. Acute administration (120 min before the test) of the H2 antagonist cimetidine induced a significant (P<0·01) increase in the TSH response to TRH, whereas treatment with histamine (30 min before the test) or with the H1-receptor blocker diphenhydramine (120 min before the test) was without effect. Treatment with cimetidine or ranitidine (another H2-receptor antagonist) for 5 days induced a marked decrease in basal plasma TSH concentrations (

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Delvalle, J., L. Wang, I. Gantz, and T. Yamada. "Characterization of H2 histamine receptor: linkage to both adenylate cyclase and [Ca2+]i signaling systems." American Journal of Physiology-Gastrointestinal and Liver Physiology 263, no. 6 (1992): G967—G972. http://dx.doi.org/10.1152/ajpgi.1992.263.6.g967.

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We undertook these studies to examine the intracellular mechanisms of histamine action using a rat hepatoma-derived cell line that had been transfected to express the H2 histamine receptor cDNA. Transfected cells demonstrated increased adenosine 3',5'-cyclic monophosphate production, membrane inositol phospholipid turnover, and intracellular Ca2+ concentration ([Ca2+]i) in response to histamine. All of the effects could be inhibited with the H2 histamine receptor antagonist cimetidine, and the increased membrane inositol phospholipid turnover and [Ca2+]i were abolished by cholera toxin pretrea

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Howard, Richard T., James P. Wilson, and James E. Smeeding. "Therapeutic Interchange of H2 Antagonists: Cost Savings and Impact on Outcomes." Hospital Pharmacy 35, no. 4 (2000): 387–93. http://dx.doi.org/10.1177/001857870003500412.

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The objective of this study was to measure the annual cost savings associated with implementation of a histamine-2 receptor (H2) antagonist therapeutic interchange program and to compare specific preimplementation and postimplementation outcome measures, specifically the incidence of adverse drug reactions (ADRs) and treatment failures. An analysis of all H2 antagonist patients was conducted at a private 59-bed, long-term, acute-care facility—1-year prior to and 1 year after an H2 antagonist therapeutic interchange program was implemented. The institution achieved a 99+% conversion of market s

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Dacey, Ralph G., and John E. Bassett. "Histaminergic Vasodilation of Intracerebral Arterioles in the Rat." Journal of Cerebral Blood Flow & Metabolism 7, no. 3 (1987): 327–31. http://dx.doi.org/10.1038/jcbfm.1987.70.

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Histamine from various sources is found in significant amounts around cerebral vessels and may play a significant role in controlling CBF. The effect of histamine on the intracerebral microcirculation has not been examined. We have used an in vitro technique for the isolation and cannulation of intracerebral arterioles from the rat to study the effect of histamine on the spontaneous tone developed by these vessels. Extraluminally administered histamine caused dose-dependent vasodilation of isolated intracerebral arterioles with a maximal dilation of 139 ± 2.4% of control diameter. The dilation

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Elizalde, Alejandro, Jesús Perez-Chavez, and José Sánchez-Chapula. "Further characterization of the receptors involved in the positive inotropic effect of histamine on rabbit papillary muscle." Canadian Journal of Physiology and Pharmacology 64, no. 12 (1986): 1484–88. http://dx.doi.org/10.1139/y86-250.

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The effects of histamine on the force of contraction and calcium-dependent action potentials were studied in rabbit ventricular papillary muscles. The positive inotropic effect of histamine seems to be dependent on stimulation of H1 and H2 receptors. The H1 antagonist chlorpheniramine produced a competitive blockade of the positive inotropic effects of histamine. Cimetidine produced a competitive blockade, which was apparent only after blockade of H1 receptors. Histamine increased the maximum upstroke velocity of slow action potentials. This effect can be entirely accounted for by stimulation

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Elenkov, Ilia J., Elizabeth Webster, Dimitris A. Papanicolaou, Thomas A. Fleisher, George P. Chrousos, and Ronald L. Wilder. "Histamine Potently Suppresses Human IL-12 and Stimulates IL-10 Production via H2 Receptors." Journal of Immunology 161, no. 5 (1998): 2586–93. http://dx.doi.org/10.4049/jimmunol.161.5.2586.

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Abstract IL-12 and IL-10, respectively, stimulate Th1 and Th2 immune responses. The development of some allergic reactions, infections, and tumors are associated with excessive histamine production and a shift toward Th2 responses. Here we address the possibility that this association is causally linked, at least in part, to modulation of IL-12 and IL-10 production by histamine. We report that histamine dose-dependently inhibited the secretion of human IL-12 (p70) and increased the production of IL-10 in LPS-stimulated whole blood cultures. These effects of histamine were antagonized by cimeti

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Benetti, Fernando, and Ivan Izquierdo. "Histamine infused into basolateral amygdala enhances memory consolidation of inhibitory avoidance." International Journal of Neuropsychopharmacology 16, no. 7 (2013): 1539–45. http://dx.doi.org/10.1017/s1461145712001514.

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Abstract The role of the basolateral amygdala (BLA) in the consolidation of aversive memory is well established. Here we investigate the involvement of the histaminergic system in BLA on this variable. Rats were chronically implanted with bilateral cannulae in the BLA and after recovery were trained in a one-trial step-down inhibitory avoidance task. Immediately after training histaminergic compounds either alone or in combination were infused through the cannulae. Memory was assessed in test sessions carried out 24 h after the training session. Post-training histamine (1–10 nmol; 0.5 µl/side)

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Hekimian, G., S. Cote, J. Van Sande, and J. M. Boeynaems. "H2 receptor-mediated responses of aortic endothelial cells to histamine." American Journal of Physiology-Heart and Circulatory Physiology 262, no. 1 (1992): H220—H224. http://dx.doi.org/10.1152/ajpheart.1992.262.1.h220.

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It is well known that umbilical vein endothelial cells express H1 receptors that mediate the various responses of these cells to histamine, including accumulation of inositol phosphates, rise of cytosolic Ca2+, increased permeability to macromolecules, and release of prostacyclin. In bovine aortic endothelial cells, histamine did not increase the level of inositol phosphates nor the release of prostacyclin. In contrast, it increased the adenosine 3',5'-cyclic monophosphate (cAMP) content of these cells. That response was obtained in the 1 to 100 microM range of concentrations and reached a max

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Keithley, Joyce K. "Histamine H2-Receptor Antagonists." Nursing Clinics of North America 26, no. 2 (1991): 361–73. http://dx.doi.org/10.1016/s0029-6465(22)00252-3.

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Pounder, Roy. "Histamine H2-receptor antagonists." Baillière's Clinical Gastroenterology 2, no. 3 (1988): 593–608. http://dx.doi.org/10.1016/s0950-3528(88)80007-1.

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Kou, Erwen, Xiaobei Zhang, Baiping Dong, Bo Wang, and Yuanjie Zhu. "Combination of H1 and H2 Histamine Receptor Antagonists: Current Knowledge and Perspectives of a Classic Treatment Strategy." Life 14, no. 2 (2024): 164. http://dx.doi.org/10.3390/life14020164.

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Histamine receptor antagonists, which can bind to specific histamine receptors on target cells, exhibit substantial therapeutic efficacy in managing a variety of histamine-mediated disorders. Notably, histamine H1 and H2 receptor antagonists have been extensively investigated and universally acknowledged as recommended treatment agents for numerous allergic diseases and acid-related disorders, respectively. Historically, the combination of H1 and H2 receptor antagonists has been considered a classic treatment strategy, demonstrating relatively superior efficacy compared with single-drug therap

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Wasserman, S. I., K. E. Barrett, P. A. Huott, G. Beuerlein, M. F. Kagnoff, and K. Dharmsathaphorn. "Immune-related intestinal Cl- secretion. I. Effect of histamine on the T84 cell line." American Journal of Physiology-Cell Physiology 254, no. 1 (1988): C53—C62. http://dx.doi.org/10.1152/ajpcell.1988.254.1.c53.

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The mast cell mediator, histamine, induces a rapid and transient increase in chloride secretion across monolayers of the human colonic epithelial cell line, T84. Threshold stimulation occurred at 3 X 10(-6) M histamine and a maximal effect at 10(-4) M. The effect was reproduced by the H1 agonists 2-methylhistamine and 2-pyridylethylamine, but not by the H2 agonists 4-methylhistamine and dimaprit, suggesting the involvement of an H1 receptor. Additionally, histamine's action was inhibited by an H1 antagonist, diphenhydramine, but not by an H2 antagonist, cimetidine. Histamine treatment increase

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Zheng, T., M. H. Nathanson, and J. A. Elias. "Histamine augments cytokine-stimulated IL-11 production by human lung fibroblasts." Journal of Immunology 153, no. 10 (1994): 4742–52. http://dx.doi.org/10.4049/jimmunol.153.10.4742.

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Abstract Histamine mediates its effects via histamine receptors and by participating in a multicellular cytokine cascade. IL-11 is a stromal cell-derived cytokine with biologic activities that overlap with IL-6. To further understand the biology of histamine and IL-11, we determined whether histamine regulates the production of IL-11 by human lung fibroblasts. Histamine was a weak stimulator of IL-11 production. Importantly, it also interacted in a synergistic fashion with TGF-beta 1 to further augment IL-11 protein production and mRNA accumulation. This synergistic interaction was not altered

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Bury, TB, and MF Radermecker. "Depression of polymorphonuclear chemotaxis and T-lymphocyte proliferation following histamine inhalation in man." European Respiratory Journal 2, no. 9 (1989): 828–33. http://dx.doi.org/10.1183/09031936.93.02090828.

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Histamine, in vitro, via H2-receptor activation, exerts an inhibitory effect on polymorphonuclear (PMN) chemotaxis and T-lymphocyte proliferation. The aim of this study was to verify these histamine inhibitory effects in man. Healthy and asymptomatic asthmatic volunteers inhaled a histamine (0.1%), methacholine (0.1%) or saline aerosol for 3 min. Asthmatics were selected on the basis of low bronchial sensitivity to pharmacological agents. Blood was taken before and at different times following aerosol challenge. PMN chemotaxis was studied in vitro by the Boyden assay. T-lymphocyte proliferatio

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Jin, Cong-Yu, Hong Wei, Kaj Karlstedt, and Antti Pertovaara. "Histamine in the locus coeruleus attenuates neuropathic hypersensitivity." Scandinavian Journal of Pain 4, no. 4 (2013): 259–60. http://dx.doi.org/10.1016/j.sjpain.2013.07.015.

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AbstractAimsAmong brain structures receiving efferent projections from the histaminergic tuberomammillary nucleus is the pontine locus coeruleus (LC), a structure involved in descending noradrenergic control of pain. Here we studied whether histamine in the LC is involved in descending regulation of neuropathic hypersensitivity.MethodsPeripheral neuropathy was induced by unilateral spinal nerve ligation (SNL) in the rat with a chronic intracerebral and intrathecal catheter for drug administrations. Mechanical hypersensitivity in the injured limb was assessed by monofilaments. Heat nociception

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Cooper, D. J., R. R. Schellenberg, and K. R. Walley. "Different effects of histamine H1 and H2 stimulation on left ventricular contractility in pigs." American Journal of Physiology-Heart and Circulatory Physiology 269, no. 3 (1995): H959—H964. http://dx.doi.org/10.1152/ajpheart.1995.269.3.h959.

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Histamine decreases ventricular contractility in some settings but increases it in others. To better understand these apparently discrepant results, we measured hemodynamics and left ventricular pressure (Millar catheter) and volume (ultrasonic crystals) in atrially paced, alpha- and beta-antagonist-treated pigs. Histamine was infused (0.5-10 micrograms.kg-1.min-1) before and after H2-antagonist (ranitidine) pretreatment. Changes in left ventricular contractile function were measured as shift of the end-systolic pressure-volume relationship (delta ESPVR) at a pressure of 100 mmHg. We found tha

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Burtin, Claude, Christian Noirot, and Pierre Scheinmann. "ANTITUMOUR ACTIVITY OF HISTAMINE PLUS H2-RECEPTOR ANTAGONIST." Lancet 332, no. 8624 (1988): 1369. http://dx.doi.org/10.1016/s0140-6736(88)90908-7.

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Black, J. W., W. A. M. Duncan, J. C. Emmett, et al. "Metiamide—An orally active histamine H2-receptor antagonist." Agents and Actions 43, no. 3-4 (1994): 91–96. http://dx.doi.org/10.1007/bf01986676.

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Wang, L., I. Gantz, and J. DelValle. "Histamine H2 receptor activates adenylate cyclase and PLC via separate GTP-dependent pathways." American Journal of Physiology-Gastrointestinal and Liver Physiology 271, no. 4 (1996): G613—G620. http://dx.doi.org/10.1152/ajpgi.1996.271.4.g613.

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Previously, we demonstrated that a single histamine H2 receptor can couple to both the adenosine 3',5'-cyclic monophosphate and inositol 1,4,5-trisphosphate/intracellular Ca2+ signaling pathways in a stimulatory manner. We undertook the present studies to fur her characterize the postreceptor events involved in H2 receptor dual signaling. Histamine H2 receptor-mediated signal transduction was examined in isolated cell membranes prepared from purified canine parietal cells and HEPA cells (rat hepatoma cell line) stably transfected to express the canine H2 histamine receptor cDNA. Histamine dose

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Siepler, John K., Walter Trudeau, and Daniel E. Petty. "Use of Continuous Infusion of Histamine2-Receptor Antagonists in Critically Ill Patients." DICP 23, no. 10_suppl (1989): S40—S43. http://dx.doi.org/10.1177/1060028089023s1007.

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Certain clinical situations require the use of a histamine2 (H2)-receptor antagonist to reduce gastric-acid volume and concentration or an antacid to act as a buffering agent. Presently, there are three H2-receptor antagonists available for iv use: Cimetidine, ranitidine, and famotidine. Conventional therapy dictates that the H2-receptor antagonist be given by intermittent intravenous infusion, resulting in peaks and valleys of acid secretory control. Antacids, although capable of providing adequate gastric acidity control, must be administered frequently, often hourly, and thus require excess

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Hemming, Jason M., Fay A. Guarraci, Tracy A. Firth, Lee J. Jennings, Mark T. Nelson, and Gary M. Mawe. "Actions of histamine on muscle and ganglia of the guinea pig gallbladder." American Journal of Physiology-Gastrointestinal and Liver Physiology 279, no. 3 (2000): G622—G630. http://dx.doi.org/10.1152/ajpgi.2000.279.3.g622.

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Histamine is an inflammatory mediator present in mast cells, which are abundant in the wall of the gallbladder. We examined the electrical properties of gallbladder smooth muscle and nerve associated with histamine-induced changes in gallbladder tone. Recordings were made from gallbladder smooth muscle and neurons, and responses to histamine and receptor subtype-specific compounds were tested. Histamine application to intact smooth muscle produced a concentration-dependent membrane depolarization and increased excitability. In the presence of the H2 antagonist ranitidine, the response to hista

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Armour, J. A. "Histamine-sensitive intrinsic cardiac and intrathoracic extracardiac neurons influence cardiodynamics." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 270, no. 4 (1996): R906—R913. http://dx.doi.org/10.1152/ajpregu.1996.270.4.r906.

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Studies were performed to determine whether 1) histamine can modify the spontaneous activity of mammalian intrinsic cardiac neurons in situ, 2) histamine-sensitive neurons exist in intrathoracic intrinsic cardiac and extracardiac ganglia that are involved in cardiac regulation, and 3) histamine-sensitive intrathoracic cardiac neurons possess H1 or H2 receptors. histamine (10 microliters; 100 microM), when applied adjacent to spontaneously active canine right atrial neurons in situ, increased ongoing activity in some of them. Histamine, when administered into the local arterial blood supply of

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Shi, Zhongcheng, Robert S. Fultz, Melinda A. Engevik, et al. "Distinct roles of histamine H1- and H2-receptor signaling pathways in inflammation-associated colonic tumorigenesis." American Journal of Physiology-Gastrointestinal and Liver Physiology 316, no. 1 (2019): G205—G216. http://dx.doi.org/10.1152/ajpgi.00212.2018.

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Inflammatory bowel disease (IBD) is a well-known risk factor for the development of colorectal cancer. Prior studies have demonstrated that microbial histamine can ameliorate intestinal inflammation in mice. We tested the hypothesis whether microbe-derived luminal histamine suppresses inflammation-associated colon cancer in Apcmin/+ mice. Mice were colonized with the human-derived Lactobacillus reuteri. Chronic inflammation was induced by repeated cycles of low-dose dextran sulfate sodium (DSS). Mice that were given histamine-producing L. reuteri via oral gavage developed fewer colonic tumors,

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