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Thematische Bibliographien / Humane Trap Development Committee / Zeitschriftenartikel

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Zeitschriftenartikel zum Thema „Humane Trap Development Committee“

Autor: Grafiati

Veröffentlicht am 4. Juni 2021

Zuletzt aktualisiert am 28. Juli 2025

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1

Proulx, Gilbert, Marc Cattet, Thomas L. Serfass, and Sandra E. Baker. "Updating the AIHTS Trapping Standards to Improve Animal Welfare and Capture Efficiency and Selectivity." Animals 10, no. 8 (2020): 1262. http://dx.doi.org/10.3390/ani10081262.

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In 1999, after pressure from the European Union, an Agreement on International Humane Trapping Standards (AIHTS) that would result in the banning of the steel-jawed leghold traps in the European Community, Canada, and Russia was signed. The United States implemented these standards through an Agreed Minute with the European Community. Over the last two decades, scientists have criticized the AIHTS for (1) omitting species that are commonly trapped; (2) threshold levels of trap acceptance that are not representative of state-of-the-art trap technology; (3) excluding popular traps which are comm

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Micińska, Magdalena. "ANIMAL TRAPS - EU AND NATIONAL REGULATIONS WITH SPECIFIC EMPHASIS ON THE AGREEMENT ON INTERNATIONAL NORMS OF HUMANE ANIMAL CAPTURE." Studia z zakresu nauk prawnoustrojowych. Miscellanea VIII, z. 2 (2018): 123–37. http://dx.doi.org/10.5604/01.3001.0013.0365.

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Animal traps have always accompanied man, with whom the primary people organized the first hunts. Along with the development of hunting art, traps gradually gave way to specialized hunting weapons. However, the use of animal traps on a large scale still occurs in countries that are world exporters of fur and skins of wild animals - Canada, Russia and the USA. Driven by expressed in art. 13 TFEU with the principle of animal welfare, the European Union has introduced a number of regulations to ensure humane catches in member countries as well as in third countries exporting skin and fur. The pur

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Leard, Katey. "Exploring Ethics in Museum Pest Management." Biodiversity Information Science and Standards 8 (October 14, 2024): e139108. https://doi.org/10.3897/biss.8.139108.

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Integrated Pest Management (IPM) has been widely employed as an effective method to control or eliminate pest populations within museum collections (Pinniger and Crossman 2021). IPM emphasizes the use of targeted treatments and pesticide alternatives including low temperature, oxygen reduction, or replacement with gasses such as nitrogen, and species-specific lures on sticky traps. These treatments, combined with routine inspections, monitoring, good housekeeping, and exclusion create a more holistic and less toxic environment for the museum's collections and people. But what about the pests t

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Kaminski, Tomasz W., Tomasz Brzoska, Egemen Tutuncuoglu, Margaret V. Ragni, and Prithu Sundd. "Neutrophil Extracellular Traps Promote Joint Injury in Hemophilia." Blood 138, Supplement 1 (2021): 990. http://dx.doi.org/10.1182/blood-2021-153645.

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Abstract Epidemiological evidence suggests that recurring episodes of joint-bleeding contribute to the development of hemophilic arthropathy (H) in 70-85% of hemophilia patients. Despite major advances in the treatment to prevent joint bleeding, HA continues to be a major morbidity affecting hemophilia patients and the etiological mechanism contributing to the progression of HA remains poorly understood. Recent evidence suggests that the accumulation of blood in the joints may lead to the release of erythrocyte-derived DAMPs (eDAMPs) such as heme and hemoglobin that can promote sterile inflamm

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Hollands, Clive. "Achieving the Achievable: A Review of Animals in Politics." Alternatives to Laboratory Animals 23, no. 1 (1995): 33–38. http://dx.doi.org/10.1177/026119299502300107.

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The background to the passage through the British Parliament of the Animals (Scientific Procedures) Act 1986 is reviewed, with particular emphasis on the significance of Animal Welfare Year (1976/77) and the role of the Houghton/Platt Memorandum and the alliance formed by the British Veterinary Association, the Committee for the Reform of Animal Experimentation and the Fund for the Replacement of Animals in Medical Experiments. The importance of the new legislation is discussed, with particular reference to the restriction of pain, the reduction in the numbers of animals used, the development

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Fleischer, Friederike. "Home, Shelter, Trap Experiences of Pandemic Con finement in Bogotá, Colombia." Built Environment 49, no. 4 (2023): 596–613. http://dx.doi.org/10.2148/benv.49.4.596.

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Drawing on data from two distinct ethnographic research projects, in this article I examine the equation of home, house, and security, as implied in the stay-at-home COVID-19 pandemic mandate. My investigation involving domestic workers in Bogotá revealed that the house is not necessarily a safe space and can sometimes even become a trap. Women's everyday lives are constrained by local labour dynamics, gender paradigms, socio-economic diff erentiation, and urban segregation, while their ontological security hinges on the proximity of close social relations. Meanwhile, research in social housin

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Kaminski, Tomasz W., Tomasz Brzoska, Egemen Tutuncuoglu, Margaret V. Ragni, and Prithu Sundd. "Neutrophil Extracellular Traps Promote Joint Injury in Hemophilia." Blood 136, Supplement 1 (2020): 43. http://dx.doi.org/10.1182/blood-2020-140173.

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Hemophilic arthropathy (HA) is the predominant pathophysiology resulting from recurrent joint bleeding in individuals with hemophilia. HA leads to permanent joint damage, chronic pain and reduced quality of life. Despite major advances in the treatment to prevent joint bleeding, HA continues to be a major morbidity affecting hemophilia patients and the etiological mechanism contributing to the progression of HA remains elusive. Recent evidence suggests that joint-bleeding may promote the release of erythrocyte and tissue-derived damage-associated-molecular-pattern molecules (DAMPs) that can tr

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Lee, Pak K. "Into the Trap of Strengthening State Capacity: China's Tax-Assignment Reform." China Quarterly 164 (December 2000): 1007–24. http://dx.doi.org/10.1017/s0305741000019275.

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The Third Plenum of the 14th Central Committee of the Chinese Communist Party (CCP) in November 1993 decided in principle for a comprehensive reform of central-provincial fiscal relations. Soon after the Plenum, the central government announced that the new fiscal system, known as the tax-assignment system (fenshuizhi), would be implemented nation-wide in 1994. With the aim of providing adequate revenues for government, particularly the central government, by revamping central-provincial revenue-sharing arrangements, the reform is to “[change] the current fiscal contractual responsibility syst

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Hukkanen, Renee R., Noel Dybdal, Niraj Tripathi, Patricia V. Turner, and Sean P. Troth. "Scientific and Regulatory Policy Committee Points to Consider*: The Toxicologic Pathologist’s Role in the 3Rs." Toxicologic Pathology 47, no. 7 (2019): 789–98. http://dx.doi.org/10.1177/0192623319859261.

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Pathologists are trained medical professionals with special expertise in diagnostics, research, and pathophysiology. In these roles, pathologists are well qualified and positioned to engage in conversations about animal use replacement, reduction, and refinement (3Rs), thereby championing the guiding principles of the 3Rs. In particular, toxicology or nonclinical safety assessment is an important area where the discipline of toxicologic pathology can have a critical role in adopting 3Rs principles. As such, a working group of the Society of Toxicologic Pathology Scientific and Regulatory Polic

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Meek, Paul D., Guy A. Ballard, and Peter J. S. Fleming. "Techniques and practices of Australian pest animal trappers." Pacific Conservation Biology 25, no. 3 (2019): 257. http://dx.doi.org/10.1071/pc18044.

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We conducted a survey of trappers to gather baseline information on the trapping methods and humane practices used in Australia, the types of traps being used, and the attitudes of trappers. Respondents indicated that they mostly trapped wild dogs and foxes with feral cats as by-catch; rabbits were trapped to a lesser degree. Respondents favoured Jake and Victor #3 traps for the capture of wild dogs. Victor #1.5, #3 and Jake traps were also favoured for capturing foxes and feral cats. Although some trappers placed up to four traps together in a set, a single trap per set was the most commonly

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Rayes, Mahmoud, Monika Mittal, Setti S. Rengachary, and Sandeep Mittal. "Hangman's fracture: a historical and biomechanical perspective." Journal of Neurosurgery: Spine 14, no. 2 (2011): 198–208. http://dx.doi.org/10.3171/2010.10.spine09805.

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The execution technique of hanging, introduced by the Angle, Saxon, and Jute Germanic tribes during their invasions of the Roman Empire and Britain in the 5th century, has remained largely unchanged over time. The earliest form of a gallows was a tree on which prisoners were hanged. Despite the introduction of several modifications such as a trap door, the main mechanism of death remained asphyxiation. This created the opportunity for attempted revival after the execution, and indeed several well-known cases of survival following judicial hanging have been reported. It was not until the introd

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Dimitrijević, Marina. "Value orientations of modern taxation." Revija Kopaonicke skole prirodnog prava 5, no. 1 (2023): 11–23. http://dx.doi.org/10.5937/rkspp2301011d.

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A comprehensive overview and understanding of modern taxation inevitably imply identifying the basic values towards which it is oriented. The noticeable dynamics of social relations, the rise of digital technologies, the complex international-economic, international-political and civilizational phenomenology of today's world make taxation an area of considerable intertwining of numerous interests. Those interests promote different values and it is uncertain which of them will prevail in a mutual confrontation. The paper advocates the position that the value orientations of taxation of the 2020

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Lester, Alan. "Obtaining the ‘Due Observance of Justice’: The Geographies of Colonial Humanitarianism." Environment and Planning D: Society and Space 20, no. 3 (2002): 277–93. http://dx.doi.org/10.1068/d42j.

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Within the context of contemporary discussion over geography and developmental ethics, this paper examines part of the genealogy of a modern British sense of responsibility for the plight of distant strangers. The frame of reference for this sense, known as humanitarianism, was first cast overseas through debates over the slave trade in the late 18th century, and its remit was further extended as a result of the contested processes of colonial settlement in the 1820s and 1830s. This geographically expansive discourse is analysed through a study of two exemplary statements of humane interventio

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Varricchio, Lilian, John Mascarenhas, Anna Rita Migliaccio та ін. "AVID200, a Potent Trap for TGF-β Ligands Inhibits TGF-β1 Signaling in Human Myelofibrosis". Blood 132, Supplement 1 (2018): 1791. http://dx.doi.org/10.1182/blood-2018-99-116474.

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Abstract Myelofibrosis (MF) is caused by driver mutations which upregulate JAK/STAT signaling. The only curative treatment for MF is hematopoietic stem cell transplant. Ruxolitinib alleviates many of the symptoms in MF but does not significantly alter survival. There is, therefore, an urgent need for additional rational therapies for MF. Bone marrow fibrosis and collagen deposition are hallmarks of MF which have been attributed to megakaryocyte (MK) derived TGFβ, which also plays a role in myelo-proliferation. There are three isoforms of TGFβ (TGFβ1, β2, and β3). AVID200, which was constructed

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Daigle, Courtney L., Xandra Christine A. Meneses, and Janice Swanson. "137 Optimizing Animal Welfare in a Socially Acceptable and Sustainable Manner: The ASAS Grand Challenge That Requires Moral Self-reflection and Scientific Calibration." Journal of Animal Science 99, Supplement_3 (2021): 71. http://dx.doi.org/10.1093/jas/skab235.129.

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Abstract Animal welfare often engages diverse values and ethics including those of citizens, consumers, scientists, and farmers. Consequently, AW is one of the seven grand challenges (GCs) identified by the ASAS Public Policy Committee (PPC). Societal concerns can lead to public policy decisions at the state or federal level that impact animal agriculture. The ASAS PPC GCs on animal welfare will be examined, progress evaluated, and recommendations made for setting research priorities. Five key questions and their corresponding expected outcomes were identified to advance AW in the GC areas of

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Xia, Jiechang, and Ting Chen. "Research on How the Digital Economy Contributes to Achieving A High-Level and Balanced Development of the Elderly Care Service Industry." China Finance and Economic Review 13, no. 3 (2024): 113–29. http://dx.doi.org/10.1515/cfer-2024-0018.

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Abstract China’s aging population has gained significant attention. Population aging implies that the demand for elderly care services will be on the rise. However, China’s aging exhibits a notable characteristic of getting old prior to achieving affluence, which directly constrains the enhancement of the level of elderly care services. The Communist Party of China and the government attach considerable importance to the issue of population aging and pensions. The Third Plenary Session of the 20th CPC Central Committee adopted the Decision of the CPC Central Committee on Further Comprehensivel

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Ahmed, S., A. Nazeer, W. Habib, S. H. Solnagi, and S. Hameed. "Assessment of the probability of success and risking in hydrocarbon exploration: A case study from Zindapir Anticline, Sulaiman Foldbelt, Indus Basin, Pakistan." Journal of Physics: Conference Series 2594, no. 1 (2023): 012002. http://dx.doi.org/10.1088/1742-6596/2594/1/012002.

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Abstract Role of the statistical calculation is very important in petroleum exploration business. It is used to calculate the associated risk and determines the chances of geological success prior to drilling of an exploratory well in mapped prospect area. This manuscript is focusing on the geological modelling of Zindapir Anticline, Sulaiman Fold Belt, Indus basin, Pakistan using mainly based on the concept of probability developed by Coordinating Committee for Coastal and Offshore Geoscience Program (CCOP) in East and Southeast Asia in 2000. Study area comprises of Zindapir Anticline with tw

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Nastoupil, Loretta J., Sattva S. Neelapu, Eric Davis та ін. "Results of a First in Human, Dose Ascending, Phase I Study Examining the Safety and Tolerability of KA2237, an Oral PI3K p110β/δ Inhibitor in Patients with Relapsed/Refractory (R/R) B-Cell Lymphoma". Blood 134, Supplement_1 (2019): 4099. http://dx.doi.org/10.1182/blood-2019-130401.

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Introduction: Despite therapeutic advances, there remains a considerable need for novel therapies for B-cell lymphomas. Although a high proportion of patients (pts) show response to initial therapy, many fail to achieve durable remissions and experience recurrent disease. Agents that target molecular pathways associated with the development and progression of lymphoma are likely to be highly effective and are desirable. The p110δ isoform of the PI3K enzyme is mainly expressed in lymphocytes and has been an attractive therapeutic target, with several PI3Kδ inhibitors demonstrating meaningful ef

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Škodrić, Ljubinka, and Bojana Femić. "GAVRILO NIKOLIĆ - OD SRESKOG PISARA DO INDUSTRIJALCA." Leskovački zbornik LXII (2022): 213. http://dx.doi.org/10.46793/lz-lxii.213s.

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Life journey of Gavrilo Nikolić has been filled with miscellaneous ups and downs some of which were caused by the turbulent period he lived in, and some by his dynamic personality and personal drive and initiative. Childhood spent in poverty, not completed high school education in Belgrade, various jobs at government along with all the transfers, dismissals, complaints, and commendation were some of the milestones in his rich career. Despite all the difficulties, Gavrilo Nikolić managed to gain recognition in a political party that gathered the intellectual and social elite. He managed to gain

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Devi, Samurailatpam P., Sinam T. Meetei, Phanjoubam Suriya, et al. "Respectful maternity care during childbirth: Experiences and observation among mothers in a tertiary-care institute in Manipur." Journal of Family Medicine and Primary Care 13, no. 5 (2024): 1766–71. http://dx.doi.org/10.4103/jfmpc.jfmpc_1840_23.

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ABSTRACT Background: Respectful maternity care (RMC) refers to the humane and dignified treatment of a childbearing woman throughout her pregnancy, childbirth and immediate postpartum period. Disrespect and abuse of women during labour, childbirth and immediate postpartum period in health facilities is one of the reasons which deter them from further utilizing maternal healthcare services. The present study was thus undertaken to determine to what extent RMC practices are being followed in a health facility in Manipur. Materials and Methods: A cross-sectional study was conducted from May 2022

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ILCHENKO, O. "V.G. KOROLENKO AGRICULTURAL YOUNG OFFENDERS INSTITUTION : EXPERIENCE OF SAFETY CHILDREN'S EDUCATION IN POLTAVA REGION." ТHE SOURCES OF PEDAGOGICAL SKILLS, no. 21 (March 9, 2018): 80–86. http://dx.doi.org/10.33989/2075-146x.2018.21.206053.

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The problem of homeless children in Ukraine of the 21th century has been updated. The best practices of one of the first managers in the Poltava region, who initiated the re-education of young people on the principles of teamwork and cohesiveness of pupils around joint productive work, were analyzed by Fedor Danilovich Ivanov, the head of the children's agricultural colony named after V.G. Korolenko.The main achievements of the colony were identified: the creation of a system of children's self-governance, the structure that included general meetings, the organizational committee, the system o

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Karasiewicz, Kathy, Shuyang He, Mary Ng, et al. "Preclinical Evaluation of Human Placental-Derived Allogeneic CD19 CAR-T Cells Against B Cell Malignancies." Blood 134, Supplement_1 (2019): 3222. http://dx.doi.org/10.1182/blood-2019-130782.

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Celularity, Inc. is developing a CD19 CAR-T Cell therapy using an allogeneic platform derived from postpartum human placental cells. T cells isolated from placenta/ umbilical cord blood and genetically modified to express CD19 chimeric antigen receptor (CAR), termed Placental-derived (P-) CD19 CAR T cells, are in development for the treatment of B cell malignancies. Unlike adult peripheral blood mononuclear cell (PBMC)-derived T cells, P-T cells are mostly naïve (CD45RA+) and can be readily expanded while maintaining an earlier differentiation phenotype such as greater expression of naïve/ mem

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ОЛЕНА, ІЛЬЧЕНКО. "ІННОВАЦІЙНИЙ ДОСВІД ВИХОВАННЯ БЕЗПРИТУЛЬНИХ ДІТЕЙ НА ПОЛТАВЩИНІ У ДОРОБКУ ФЕДОРА ІВАНОВА(20-30-і рр. ХХ ст.)". Педагогічні науки, № 69 (31 травня 2018): 141–46. https://doi.org/10.5281/zenodo.1256691.

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The problem of homeless children in Ukraine of the 21th century has been updated. The best practices of one of the first managers in the Poltava region, who initiated the re-education of young people on the principles of teamwork and cohesiveness of pupils around joint productive work, were analyzed by Fedor Danilovich Ivanov, the head of the children's agricultural colony named after V.G. Korolenko. The main achievements of the colony were identified: the creation of a system of children's self-governance, the structure that included general meetings, the orga

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Boreddy, Srinivas Reddy, Reshmi Nair, Arindam Banerjee та ін. "874 Development of BCA101, a bifunctional antibody capable of simultaneously disabling EGFR and TGFβ signaling, as novel single-agent immunotherapy". Journal for ImmunoTherapy of Cancer 9, Suppl 2 (2021): A915—A916. http://dx.doi.org/10.1136/jitc-2021-sitc2021.874.

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BackgroundGiven the pleiotropic functions of transforming growth factor-beta (TGFβ), current approaches to targeting systemic TGFβ will likely lead to suboptimal clinical activity and/or undesirable effects. Epidermal growth factor receptor (EGFR) is one of the most extensively validated tumor-associated antigens. Bicara Therapeutics has developed a novel bifunctional fusion protein, composed of a monoclonal antibody against EGFR and an extracellular domain of human TGFβ receptor II (TGFβRII). We demonstrate BCA101 has the potential to improve anti-tumor response by leveraging the cooperativit

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Polokhov, D. M., A. V. Pshonkin, A. A. Ignatova, et al. "Specifities of the storage pool and morphology of platelets in children with unspecified hemorrhagic syndrome." Pediatric Hematology/Oncology and Immunopathology 20, no. 1 (2021): 58–65. http://dx.doi.org/10.24287/1726-1708-2021-20-1-58-65.

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Despite modern possibilities of laboratory diagnosis of hemorrhagic syndrome, in some patients, the causes of bleeding remain unspecified. Among these reasons, mild defects in the platelet link of hemostasis can potentially be hidden. The aim of the work is to identify the features of the function of the platelet hemostasis in children with unspecified hemorrhagic syndrome. This study is supported by the Independent Ethics Committee and approved by the Academic Council of the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology. We examined 50 patie

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Jiang, Feng, Hong Wang, Tsz-Lun Yeung та ін. "609 Combining bintrafusp alfa with abituzumab enhances suppression of the TGF-β signaling pathway". Journal for ImmunoTherapy of Cancer 9, Suppl 2 (2021): A639. http://dx.doi.org/10.1136/jitc-2021-sitc2021.609.

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BackgroundBintrafusp alfa is a first-in-class bifunctional fusion protein composed of the extracellular domain of the TGF-βRII receptor fused to a human IgG1 antibody blocking PD-L1. The TGF-βRII moiety of bintrafusp alfa functions as a ”trap” to sequester active TGF-β but does not block TGF-β release from its latent form. Multiple mechanisms lead to the release of active TGF-β. Integrins control local activation of latent TGF-β stored in the extracellular matrix and cell-surface reservoirs in the tumor microenvironment (TME). Alpha v integrin mRNA expression is correlated with multiple TGF-β

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Brunetti, Giacomina, Rita Rizzi, Angela Oranger, et al. "The Role of LIGHT in Multiple Myeloma-Bone Disease." Blood 124, no. 21 (2014): 3362. http://dx.doi.org/10.1182/blood.v124.21.3362.3362.

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Abstract Background. The TNF superfamily member LIGHT, known to play a major role in T-cell homeostasis, has been reported in erosive bone disease associated with rheumatoid arthritis. Herein, we investigated whether LIGHT is implicated in the mechanisms leading to Multiple Myeloma (MM)-bone disease. Methods. Peripheral blood (PB) and bone marrow (BM) aspirates were obtained from 40 patients (23M/17F, median age: 64 years), newly diagnosed as having symptomatic MM with or without bone disease, smoldering MM (sMM) or M.G.U.S. Bone disease assessment was performed by skeleton x-Ray, and spine an

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Isabekov, Nikolay R., Anton A. Tonshin, and Evgenij Yu Bonitenko. "Hypothermia induced by bronchoalveolar lavage with perfluorocarbon liquids as a method for the treatment of the alveolar stage of toxic pulmonary edema. Experimental assessment." Russian Journal of Occupational Health and Industrial Ecology 64, no. 5 (2024): 293–302. http://dx.doi.org/10.31089/1026-9428-2024-64-5-293-302.

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Introduction. The rapid development of the chemical industry in the Russian Federation is accompanied by an increase in the production and storage of highly toxic substances belonging to the group of pulmonotoxicantsare able to induce lung injury, the most severe form of which is toxic pulmonary edema (TPE). The treatment of TPE includes medication and respiratory therapy, but such a combination turns out to be insufficient, and therefore the development of new methods of treatment of the alveolar stage is an important task of modern medicine. One such approach is the use of therapeutic hypoth

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Suber, Yani B., Bhavya S. Doshi, Robert A. French, Elizabeth Merricks, Timothy Nichols, and Ben Samelson-Jones. "Success of Immune Tolerance Induction after AAV Gene Therapy in High-Responding Inhibitor Hemophilia a Dogs May be F8 Genotype Dependent." Blood 144, Supplement 1 (2024): 3579. https://doi.org/10.1182/blood-2024-199820.

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Background The development of neutralizing alloantibodies (inhibitors) remains the major side effect of factor VIII (FVIII) replacement therapy for hemophilia A (HA). Inhibitors significantly increase morbidity and mortality. Though the advent of non-factor therapies for HA has dramatically improved hemostatic prophylaxis for inhibitor patients, inhibitor eradication and immune tolerance induction (ITI) remain essential therapeutic goals. Recombinant adeno-associated viral (rAAV) gene therapy for HA has almost completely excluded patients with current or a history of inhibitors. We have previo

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Isabekov, Nikolay R., Anton A. Tonshin, and Evgenij Yu Bonitenko. "Justification of the possibility of using liquid artificial lung ventilation for the treatment of acute respiratory distress syndrome of toxic genesis." Russian Journal of Occupational Health and Industrial Ecology 64, no. 8 (2024): 506–17. http://dx.doi.org/10.31089/1026-9428-2024-64-8-506-517.

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Introduction. Pulmonotoxicants are chemicals that cause bronchospasm and damage to the alveolar capillary membrane. Lesions of the respiratory system with pulmonotoxicants in industrial accidents are especially relevant at the present time. Existing methods of treatment for the defeat of pulmonotoxicants and the development of acute respiratory distress syndrome (ARDS) are becoming ineffective, therefore, one of the tasks of modern medicine is to develop new methods of treating ARDS. One of these methods may be the creation of a "therapeutic window" by using perfluorocarbon (PFC) liquids. This

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Ravindranathan, Sruthi, Tenzin Passang Fnu, Jian Ming Li, et al. "748 Targeting vasoactive intestinal peptide receptor signaling in pancreatic ductal adenocarcinoma for enhanced anti-tumor response to checkpoint blockade." Journal for ImmunoTherapy of Cancer 9, Suppl 2 (2021): A779—A781. http://dx.doi.org/10.1136/jitc-2021-sitc2021.748.

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BackgroundPaucity of T cells in the immune privileged tumor microenvironment (TME) of pancreatic ductal adenocarcinoma (PDAC) is a major reason that PDAC is refractory to immune checkpoint blockade.1 In this study, we show that human PDAC tumors over-express vasoactive intestinal peptide (VIP), an immunosuppressive neuropeptide, that inhibits effector T cell responses and regulates chemokine receptor expression on activated T cells.2 3 We thus hypothesized that pharmacological inhibition of VIP receptor signaling could enhance anti-tumor responses in PDAC.MethodsVIP levels in plasma were deter

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Isabekov, Nikolay R., Anton A. Tonshin, Oleg V. Krikunov, and Evgenij Yu Bonitenko. "The use of gas-liquid artificial lung ventilation in acute inhalation chlorine poisoning (experimental study)." Russian Journal of Occupational Health and Industrial Ecology 65, no. 1 (2025): 4–17. https://doi.org/10.31089/1026-9428-2025-65-1-4-17.

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Introduction. Currently, chlorine is widely used in industry and agriculture. There are thousands of industrial facilities located on the territory of the Russian Federation that have chlorine reserves in quantities that, in the event of an emergency, can lead to massive damage to people. Chlorine poisoning has stages of development of the toxic process with the development of toxic pulmonary edema (TPE). Respiratory therapy for TPE consists in the use of artificial lung ventilation (ALV) with positive pressure at the end of exhalation and an oxygen content in the inhaled mixture (FiO2) of at

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Ray, Arghya, Deepika Sharma DAS, Yan Song, et al. "A Novel Agent SL-401 Triggers Anti-Myeloma Activity By Targeting Plasmacytoid Dendritic Cells: Implications for a Novel Immune-Associated Mechanism." Blood 126, no. 23 (2015): 3000. http://dx.doi.org/10.1182/blood.v126.23.3000.3000.

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Abstract Introduction Multiple myeloma (MM) remains incurable despite novel therapies, highlighting the need for further identification of factors mediating disease progression and resistance. Our studies have identified an integral role of bone marrow (BM) plasmacytoid dendritic cells (pDCs) in MM pathogenesis. The functional significance of increased numbers of pDCs in MM BM is evident from our observations that pDCs: are relatively resistant to novel and conventional therapies; protect tumor cells from therapy-induced cytotoxicity; promote tumor growth and survival; and suppress immune resp

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Meneses, Aérica De Figueiredo Pereira, Priscilla Perla Tartarotti Von Zuben Campos, Sandra Francisca Bezerra Gemma, and Marta Fuentes-Rojas. "Seminários interdisciplinares como instrumento de articulação de saberes: um relato de experiência (Interdisciplinary seminars as an instrument for articulation of knowledge: an experience report)." Revista Eletrônica de Educação 13, no. 1 (2019): 336. http://dx.doi.org/10.14244/198271992532.

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The purpose of this article was to report on the experience of interdisciplinary practices where the seminar model was used as a methodological strategy for the debate of contemporary issues. In this sense, a description is given of the activities carried out in the Interdisciplinary Seminar ERGOLAB and LAPSIC (SIEL), event held at Faculdade de Ciências Aplicadas (FCA) of the Universidade Estadual de Campinas (UNICAMP), with the aim of contributing to the interdisciplinary treatment of contemporary problems, creating a space of reference for the various themes of research. The Seminar in quest

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Akmal, SAIDOV. "NEW UZBEKISTAN ON THE WAY OF THE ONGOING REFORMS." Demokratlashtirish va Inson huquqlari 1/2022 (May 10, 2023): 64–68. https://doi.org/10.54952/DHR.2022.16.99.004.

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Last year the Uzbek people has celebrated the 30th anniversary of the Independence. During last 5 years the large-scale creative and improving work is being carried out on the idea “New Uzbekistan”. Human rights protection is considered one of the priorities of our state policy. Today the country has a stable political system that meets the modern criteria of democracy and human rights, and the legislative, executive and judicial authorities at all levels are actively working to strengthen respect for human rights and to promote human rights education throughout the country. But th

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Trystanto, Trystanto. "Small Governing Coalition in Hong Kong and its Impact on Political Freedom." Jurnal Sentris 4, no. 1 (2023): 46–60. http://dx.doi.org/10.26593/sentris.v4i1.6346.46-60.

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Hong Kong has seen an upheaval in recent years. From the protests over the extradition law to the protests over the National Security Law, these protests are a response to the ever-encroaching hand of Beijing on political rights in Hong Kong. After the National Security Law was implemented, Hong Kong’s freedom was almost gone. One by one, pro-democracy protesters, opposition parliament members, and opposition media are being targeted and repressed. Despite the numerous protests and riots, the Hong Kong SAR government perseveres with little concession to the protesters. Why does the government

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Ortlund, Gavin. "Retrieving Augustine's Doctrine of Creation: Ancient Wisdom for Current Controversy." Perspectives on Science and Christian Faith 73, no. 3 (2021): 188–89. http://dx.doi.org/10.56315/pscf9-21ortlund.

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RETRIEVING AUGUSTINE'S DOCTRINE OF CREATION: Ancient Wisdom for Current Controversy by Gavin Ortlund. Downers Grove, IL: IVP Academic, 2020. 264 pages. Paperback; $30.00. ISBN: 9780830853243. *With a long career (of some 40 years) and even longer paper trail (approximately 94 books with all but one surviving, between 4,000-10,000 sermons with approximately 950 available still, and nearly 300 letters extant), Augustine holds a central position as one of the most influential of theologians. He is quoted often--and too often as an authoritative proof text for one's favored position. Yet he is not

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Matyzhanov, Kenzhekhan. "Games and rituals are the most important means of social interaction in human society." Keruen 72, no. 3 (2021). http://dx.doi.org/10.53871/2078-8134.2021.3-01.

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The article comprehensively investigates the phenomenon of play and its relationship with cultural and social categories such as ritual, ritual, customs, and traditions based on folklore and ethnographic materials of the Kazakh and Turkic peoples. Game culture as the most active means of cultural and social interaction in society, deeply rooted in all spheres of human life, is an integral element of the development of modern society. Folk customs and traditions are reflected in religion, arts, crafts, politics, science, military sports games, education, upbringing, economics, and entrepreneurs

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Leard, Katey. "Exploring Ethics in Museum Pest Management." Biodiversity Information Science and Standards 8 (October 14, 2024). http://dx.doi.org/10.3897/biss.8.139108.

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Integrated Pest Management (IPM) has been widely employed as an effective method to control or eliminate pest populations within museum collections (Pinniger and Crossman 2021). IPM emphasizes the use of targeted treatments and pesticide alternatives including low temperature, oxygen reduction, or replacement with gasses such as nitrogen, and species-specific lures on sticky traps. These treatments, combined with routine inspections, monitoring, good housekeeping, and exclusion create a more holistic and less toxic environment for the museum’s collections and people. But what about the pests t

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Agrawal, Vipin K., Frank Tenkorang, Vijay K. Agrawal, and Allen R. Taylor. "Trends In IT Human Resources And Its Impact On Curriculum Design." Review of Business Information Systems (RBIS) 13, no. 4 (2009). http://dx.doi.org/10.19030/rbis.v13i4.4314.

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In light of rapid changes in technology and business, institutions of higher education face the difficult task of adapting their curriculum to be general enough to cover all the core concepts of the discipline while being specific enough to prepare students with the knowledge and skills needed by businesses. The Bureau of Labor Statistics (BLS) forecasts that the demand for IT professionals in the United States will continue to increase but the demand will not be evenly distributed across all areas. The BLS breaks future demand into job categories but it does not explore the meta-trends that w

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Hellwig, Brant J., and Gregg D. Polsky. "Litigation Expenses and the Alternative Minimum Tax." Florida Tax Review 6, no. 9 (2004). https://doi.org/10.5744/ftr.2004.1092.

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As the Article was going to press, a modified version of the Senate bill described in Part III cleared the Congressional conference committee and became effective when President Bush signed it into law on October 22, 2004 as part of the American Jobs Creation Act of 2004. This legislative development and its impact on the issues discussed in the Article are briefly addressed in an Addendum.One of the chief features of the alternative minimum tax (the "AMT") is a broadened tax base, accomplished in part through the disallowance of deductions that are not central to measuring an individual's net

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Gauvin, David V., Margaret McComb, and Ryan Farero. "A Commentary on Fasting of Nonclinical Research Animals." International Journal of Toxicology, December 27, 2023. http://dx.doi.org/10.1177/10915818231218975.

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This commentary discusses the implementation of fasting in nonclinical animal experimental subjects. The short-term removal of food from cages of experimental animals is in all respects innocuous. The term “stress” is ill-defined and the statutes and regulations governing animal research laboratories that exert their authority in the performance of their operations do so without substantive grounds to base compliance. The legislative and administrative history of the implementation of the Animal Welfare Act (AWA) has evolved into the development of laboratory management strategies that focus o

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Childers, Chad. "Extending Animal Cruelty Protections to Scientific Research." Voices in Bioethics 8 (July 5, 2022). http://dx.doi.org/10.52214/vib.v8i.9490.

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Photo by Sandy Millar on Unsplash INTRODUCTION On November 25, 2019, the federal law H.R. 724 – the Preventing Animal Cruelty and Torture Act (PACT) prohibiting the intentional harm of “living non-human mammals, birds, reptiles, or amphibians” was signed.[1] This law was a notable step in extending protections, rights, and respect to animals. While many similar state laws existed, the passing of a federal law signaled a new shift in public tone. PACT is a declaration of growing societal sentiments that uphold the necessity to shield our fellow creatures from undue harm. Protecting animals from

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DSOUZA, RUDOLPH. "REFORM THE JUSTICE SYSTEM TO PREVENT FUTURE INJUSTICE." June 4, 2021. https://doi.org/10.5281/zenodo.4899760.

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<strong>According to records available at the Supreme Court of India website, there are currently more than 44 million cases (4.4 crores) pending in Indian courts. As of April 2021, the number of pending cases in the Supreme Court are around 62000, more than five and half million cases in High courts (57.53 lakhs) and more than 38 million (3.81 crores) cases in lower courts.</strong> <strong>One of the primary reasons for such a backlog is nexus between police, lawyers and judges. This nexus is responsible for promoting corruption and has other vested interests for doing so. Specially they fav

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Keogh, Luke. "The First Four Wells: Unconventional Gas in Australia." M/C Journal 16, no. 2 (2013). http://dx.doi.org/10.5204/mcj.617.

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Unconventional energy sources have become increasingly important to the global energy mix. These include coal seam gas, shale gas and shale oil. The unconventional gas industry was pioneered in the United States and embraced following the first oil shock in 1973 (Rogers). As has been the case with many global resources (Hiscock), many of the same companies that worked in the USA carried their experience in this industry to early Australian explorations. Recently the USA has secured significant energy security with the development of unconventional energy deposits such as the Marcellus shale ga

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Castelyn, Camille. "Shifting Perceptions of CRISPR." Voices in Bioethics 7 (August 4, 2021). http://dx.doi.org/10.52214/vib.v7i.8595.

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   Photo by National Cancer Institute on Unsplash INTRODUCTION More than 20 cell and gene therapies are now available to safely minimize genetic diseases such as retinal dystrophy (LUXTURNA), some B-cell lymphomas (YESCARTA), and B-cell lymphoblastic leukemia (KYMRIAH).[1] One such gene-editing tool is Clustered Regular Inter Spaced Palindromic Repeats (CRISPR) and its associated proteins or CRISPR-Cas. Jennifer Doudna and Emmanuelle Charpentier described CRISPR’s potential as an accurate genome editing tool in 2012. The FDA approved the first cell and gene therap

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Swidler, Robert. "End-of-Life Decisions for Isolated Patients Under New York's Family Health Care Decisions Act." Voices in Bioethics 10 (September 19, 2024). http://dx.doi.org/10.52214/vib.v10i.12989.

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Photo ID 6232629 © Mykola Velychko | Dreamstime.com ABSTRACT The most challenging end-of-life cases involve patients who lack capacity and have no surrogate decision-makers. New York's Family Health Care Decisions Act provides alternative criteria for withdrawing or withholding treatment in such cases, including the requirement that the patient "will die imminently, even if the treatment is provided." This article clarifies the interpretation of "imminent" and offers recommendations to improve end-of-life policies, including greater reliance on Ethics Review Committees (ERCs). INTRODUCTION Pro

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Caesar Dib, Caio. "Bioethics-CSR Divide." Voices in Bioethics 10 (March 21, 2024). http://dx.doi.org/10.52214/vib.v10i.12376.

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Photo by Sean Pollock on Unsplash ABSTRACT Bioethics and Corporate Social Responsibility (CSR) were born out of similar concerns, such as the reaction to scandal and the restraint of irresponsible actions by individuals and organizations. However, these fields of knowledge are seldom explored together. This article attempts to explain the motives behind the gap between bioethics and CSR, while arguing that their shared agenda – combined with their contrasting principles and goals – suggests there is potential for fruitful dialogue that enables the actualization of bioethical agendas and provid

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Dolomatov, S.I., та W. Zukow. "Эпигенетика почек = Kidneys epigenetics". 7 липня 2019. https://doi.org/10.5281/zenodo.3270754.

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<strong>Dolomatov S.I., Zukow W. </strong><strong>Эпигенетика почек</strong><strong> = Kidney</strong><strong>s</strong><strong> epigenetics</strong><strong>. </strong><strong>RSW. Radom,</strong><strong> 144 </strong><strong>p. ISBN </strong><strong>9780359774524</strong><strong>.</strong><strong> DOI </strong><strong>http://dx.doi.org/10.5281/zenodo.3270699</strong><strong> PBN Poland </strong><strong>https://pbn.nauka.gov.pl/sedno-webapp/works/917606</strong>           <strong>Radomska Szkoła Wyższa w Radomiu, Radom, Poland</strong>         &nbsp

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