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Thematische Bibliographien / Immune response Molecular aspects

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Auswahl der wissenschaftlichen Literatur zum Thema „Immune response Molecular aspects“

Autor: Grafiati

Veröffentlicht am 4. Juni 2021

Zuletzt aktualisiert am 1. Februar 2023

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Zeitschriftenartikel zum Thema "Immune response Molecular aspects"

1

AS, Dr Maniyammai, Dr Amudha M, Dr Renuka Devi R, Dr Esther Nalini H, and Dr Arun Kumar Prasad. "Adaptive immune response: Molecular aspects of periodontal disease." International Journal of Applied Dental Sciences 7, no. 4 (October 1, 2021): 89–92. http://dx.doi.org/10.22271/oral.2021.v7.i4b.1356.

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Goodman, Jesse L. "Molecular Aspects of Immune Response in Infectious Diseases." Clinical Infectious Diseases 13, no. 3 (May 1, 1991): 530. http://dx.doi.org/10.1093/clinids/13.3.530-a.

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Inman, R. D. "Immunogenetic aspects of host immune response." Canadian Journal of Microbiology 34, no. 3 (March 1, 1988): 319–22. http://dx.doi.org/10.1139/m88-058.

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The central role of histocompatibility leukocyte antigens (HLA) class II molecules in antigen presentation has received great attention in recent years, yet class I molecules have been defined as primarily functioning as a restriction element for cytotoxic T cell killing of virus-infected cells. Extensive clinical evidence, however, indicates that the HLA class I genes are strongly associated with nonseptic complications of enteric and genitourinary bacterial infections. Ninety percent of patients with Reiter's syndrome and reactive arthritis are positive for HLA-B27, yet the mechanism of dise

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Jeffries, Donald. "Book Review: Molecular Aspects of Immune Response and Infectious Diseases." International Journal of STD & AIDS 2, no. 3 (May 1991): 218. http://dx.doi.org/10.1177/095646249100200322.

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Stetson, C. A., and E. Jensen. "HUMORAL ASPECTS OF THE IMMUNE RESPONSE TO HOMOGRAFTS *." Annals of the New York Academy of Sciences 87, no. 1 (December 15, 2006): 249–57. http://dx.doi.org/10.1111/j.1749-6632.1960.tb23198.x.

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INNES, ELISABETH A., DAVID BUXTON, STEPHEN MALEY, STEPHEN WRIGHT, JOANNE MARKS, IRMA ESTEBAN, ALISTAIR RAE, ALEX SCHOCK, and JONATHAN WASTLING. "Neosporosis: Aspects of Epidemiology and Host Immune Response." Annals of the New York Academy of Sciences 916, no. 1 (January 25, 2006): 93–101. http://dx.doi.org/10.1111/j.1749-6632.2000.tb05278.x.

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Sonenshine, Daniel, E. "Molecular characterization and related aspects of the innate immune response in ticks." Frontiers in Bioscience Volume, no. 13 (2008): 7046. http://dx.doi.org/10.2741/3209.

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Nikolic, Dejan, Milena Jankovic, Bojana Petrovic, and Ivana Novakovic. "Genetic Aspects of Inflammation and Immune Response in Stroke." International Journal of Molecular Sciences 21, no. 19 (October 8, 2020): 7409. http://dx.doi.org/10.3390/ijms21197409.

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Genetic determinants play important role in the complex processes of inflammation and immune response in stroke and could be studied in different ways. Inflammation and immunomodulation are associated with repair processes in ischemic stroke, and together with the concept of preconditioning are promising modes of stroke treatment. One of the important aspects to be considered in the recovery of patients after the stroke is a genetic predisposition, which has been studied extensively. Polymorphisms in a number of candidate genes, such as IL-6, BDNF, COX2, CYPC19, and GPIIIa could be associated

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Petean, Igor Bassi Ferreira, Alice Corrêa Silva-Sousa, Tamara Justiniano Cronenbold, Jardel Francisco Mazzi-Chaves, Lea Assed Bezerra da Silva, Raquel Assed Bezerra Segato, Guilherme Assed Piedade de Castro, Erika Calvano Kuchler, Francisco Wanderley Garcia Paula-Silva, and Manoel Damião Sousa-Neto. "Genetic, Cellular and Molecular Aspects involved in Apical Periodontitis." Brazilian Dental Journal 33, no. 4 (August 2022): 1–11. http://dx.doi.org/10.1590/0103-6440202205113.

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Abstract The development, establishment and repair of apical periodontitis (AP) is dependent of several factors, which include host susceptibility, microbial infection, immune response, quality of root canal treatment and organism's ability to repair. The understanding of genetic contributions to the risk of developing AP and presenting persistent AP has been extensively explored in modern Endodontics. Thus, this article aims to provide a review of the literature regarding the biochemical mediators involved in immune response signaling, osteoclastogenesis and bone neoformation, as the genetic

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McNamara, Mairéad G., Jean-Yves Scoazec, and Thomas Walter. "Extrapulmonary poorly differentiated NECs, including molecular and immune aspects." Endocrine-Related Cancer 27, no. 7 (July 2020): R219—R238. http://dx.doi.org/10.1530/erc-19-0483.

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Patients with extrapulmonary poorly differentiated neuroendocrine carcinomas (EP-PD-NECs) have a poor prognosis. Surgery is offered for those with localised disease, but the majority of patients present with advanced disease. Treatment strategies adopted are analogous to that of high grade NECs of the lung, with platinum/etoposide-based regimens advocated in the first-line setting for advanced disease. There is no standard second-line therapy. Research into their molecular and immune pathways may pave the way for novel drug discovery. The molecular drivers of NEC are best identified in small c

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Dissertationen zum Thema "Immune response Molecular aspects"

1

Morley, Sarah Louise. "Molecular aspects of the humoral immune response against Neisseria meningitidis." Thesis, Imperial College London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424765.

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Wong, Lik-wai Benny, and 黃力偉. "Immune response and signaling mechanisms of Helicobacter pylori induced gastritis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43224313.

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Prabhala, Rao H. "Two different molecular pathways of immunomodulation by retinoids and carotenoids." Diss., The University of Arizona, 1989. http://hdl.handle.net/10150/184676.

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Epidemiological studies suggest that both retinoid and carotenoid intakes are inversely correlated with the incidence of human cancers. Animal studies show that both retinoids and carotenoids inhibit tumor cell growth. Both retinoids and carotenoids activate the cytotoxicity function of macrophages in animal experiments. The purpose of this study is to evaluate the molecular mechanism for 13-cis retinoic acid (13-cRA) and beta-carotene (BC) induced immunomodulation which could explain their anti-cancer affects. The effects of 13-cRA and BC were studied on various subpopulations of T-lymphocyte

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Swanson, Kara M., and n/a. "The bovine mammary gland immune response to Streptococcus uberis and its bacteriocins." University of Otago. Department of Microbiology & Immunology, 2008. http://adt.otago.ac.nz./public/adt-NZDU20080407.112302.

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Bovine mastitis is one of the most costly dairy-based diseases worldwide. Streptococcus uberis is a prevalent causative organism of mastitis and resides naturally in the environment of the dairy cow making prevention of the disease difficult. New strategies need to be developed to control this pathogen. However, a fundamental understanding of the complex relationships that exist between the cow, the pathogen and the environment are required in order to advance the development of prevention strategies. Microarray technology was used to evaluate the complex transcriptional changes which occur in

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Chakravarti, Sumone. "The cloning and functional characterisation of murine phosphatidylinositol 3-kinase gamma." Title page, table of contents and abstract only, 2001. http://web4.library.adelaide.edu.au/theses/09PH/09phc4355.pdf.

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Mooney, John. "Molecular and cellular aspects of the humoral immune response in periodontal disease and other related conditions." Thesis, University of Glasgow, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321510.

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Sumaria, Nital. "The relevance of specific molecular and cellular effectors during murine cytomegalovirus infection." University of Western Australia. School of Biomedical, Biomolecular and Chemical Sciences, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0116.

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[Truncated abstract] The design and development of effective anti-viral immunotherapies requires a comprehensive understanding of the cellular and molecular processes that are involved in the generation and regulation of immune responses. The fundamental objective of the immune system is to successfully complete the task of eliminating/controlling the invading pathogen without causing overt pathology. Cytomegaloviruses (CMVs) are large DNA viruses that are able to evade immune attack and persist lifelong within the host. In a healthy host, CMV causes an asymptomatic infection, but in instances

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Andrews, Daniel Mark. "Effects of murine cytomegalovirus infection on dendritic cell functionality and natural killer cell responses." University of Western Australia. Centre for Ophthalmology and Visual Science, 2004. http://theses.library.uwa.edu.au/adt-WU2005.0003.

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Cytomegaloviruses (CMVs) are ubiquitous in nature, having evolved over many millenia with their hosts. While in healthy hosts most infections with CMV are asymptomatic, the virus can cause severe disease in immunocompromised hosts. Thus, the increase in organ transplantation and the HIV/AIDS pandemic have established human CMV (HCMV) as a clinically important pathogen. Indeed, HCMV infections are now the major cause of morbidity and mortality among immunocompromised patients, which has led to more research targeting CMV for effective anti-viral treatment. The discovery that cytomegaloviruses e

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Kodituwakku, Aruna Poojitha. "Antigen specific B cells in the immune response to Haemophilus influenzae type b PRP conjugate vaccine /." Title page, table of contents and summary only, 2004. http://web4.library.adelaide.edu.au/theses/09PH/09phk769.pdf.

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Khong, Andrea. "Effect of murine cytomegalovirus infection on haematopoiesis and myeloid cell differentiation and function." University of Western Australia. School of Biomedical, Biomolecular and Chemical Sciences, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0260.

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Cytomegalovirus (CMV) is a ubiquitous pathogen affecting over 95% of the worlds population. While infection is typically asymptomatic in healthy individuals, the virus persists life-long in its host and can be reactivated following withdrawal of immune control. As such, it remains a serious clinical concern in individuals who are immunocompromised, such as newborns and neonates, transplant and/or chemotherapy recipients, and HIV/AIDS patients. CMV also has the ability to cause immunosuppression, the mechanisms of which include defective antigen presentation to T cells and interference with ha

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Bücher zum Thema "Immune response Molecular aspects"

1

1956-, Srivastava Rakesh, Ram Bhanu P. 1951-, and Tyle Praveen 1960-, eds. Molecular mechanisms of immune regulation. New York, N.Y: VCH Publishers, 1991.

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Delʹvig, A. A. Kletochnye i molekuli︠a︡rnye osnovy prezentat︠s︡ii antigenov. Moskva: Medit︠s︡ina, 2004.

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Wayne, Streilein J., ed. Advances in gene technology: The molecular biology of immune diseases and the immune response : proceedings of the 1990 Miami Bio/Technology Winter Symposia. Oxford: IRL Press at Oxford University Press, 1990.

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Mak, Tak W. Handbook of immune response genes. New York: Plenum Press, 1998.

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Miami Bio/Technology Winter Symposia (1990). Advances in gene technology: The molecular biology of immune diseases and the immune response : proceedings of the 1990 Miami Bio/Technology Winter Symposia. Oxford ; New York: IRL Press at Oxford University Press, 1990.

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Green Cross International Symposium (1st 1992 Kyoto). Molecular basis of immune responses: [proceedings of the First Green Cross International Symposium "immunology for tomorrow" 1992]. Tokyo: Academic Press, 1993.

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Miami Bio/Technology Winter Symposium (1990 Miami, Fla.). Advances in gene technology: The molecular biology of immune diseases and the immune reponse : proceedings of the 1990 Miami Bio/Technology Winter Symposia. Oxford: IRL Press, 1990.

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Donata, Vercelli, ed. IgE regulation: Molecular mechanisms. Chichester: J. Wiley, 1997.

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Akira, Wake. Host-parasite relationships and the Yersinia model. New York: Springer-Verlag, 1986.

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D, Batista Facundo, and SpringerLink (Online service), eds. Immunological Synapse. Berlin, Heidelberg: Springer-Verlag Berlin Heidelberg, 2010.

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Buchteile zum Thema "Immune response Molecular aspects"

1

Liu, G., A. Keane-Myers, D. Miyazaki, A. Tai, and S. J. Ono. "Molecular and Cellular Aspects of Allergic Conjunctivitis." In Immune Response and the Eye, 39–58. Basel: KARGER, 1999. http://dx.doi.org/10.1159/000058748.

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McFarland, Henry F., and Steven Jacobson. "The Immune Response to Viruses." In Clinical and Molecular Aspects of Neurotropic Virus Infection, 469–99. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4613-1675-6_17.

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Milich, David R. "Molecular and Genetic Aspects of the Immune Responses to Hepatitis B Viral Antigens." In The Immune Response to Viral Infections, 115–33. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4684-5712-4_12.

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Tavasolian, Fataneh, Gholam Reza Hatam, Sayed Hussain Mosawi, Mahdiyar Iravani Saadi, Elham Abdollahi, Tannaz Jamialahmadi, Thozhukat Sathyapalan, and Amirhossein Sahebkar. "The Immune Response and Effectiveness of COVID-19 Therapies." In Clinical, Biological and Molecular Aspects of COVID-19, 115–26. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-59261-5_10.

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Spiegel, Allen M. "Guanine Nucleotide Regulatory Proteins in Inflammatory and Immune Responses." In Cellular and Molecular Aspects of Inflammation, 209–27. Boston, MA: Springer US, 1988. http://dx.doi.org/10.1007/978-1-4684-5487-1_11.

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Siliciano, R. F. "Molecular Aspects of Human B and T Lymphocyte Responses to HIV." In Herpesviruses, the Immune System, and AIDS, 45–71. Boston, MA: Springer US, 1990. http://dx.doi.org/10.1007/978-1-4613-1507-0_3.

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Neagu, Monica, and Carolina Constantin. "Signal Transduction in Immune Cells and Protein Kinases." In Advances in Experimental Medicine and Biology, 133–49. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-49844-3_5.

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AbstractImmune response relies upon several intracellular signaling events. Among the protein kinases involved in these pathways, members of the protein kinase C (PKC) family are prominent molecules because they have the capacity to acutely and reversibly modulate effector protein functions, controlling both spatial distribution and dynamic properties of the signals. Different PKC isoforms are involved in distinct signaling pathways, with selective functions in a cell-specific manner.In innate system, Toll-like receptor signaling is the main molecular event triggering effector functions. Various isoforms of PKC can be common to different TLRs, while some of them are specific for a certain type of TLR. Protein kinases involvement in innate immune cells are presented within the chapter emphasizing their coordination in many aspects of immune cell function and, as important players in immune regulation.In adaptive immunity T-cell receptor and B-cell receptor signaling are the main intracellular pathways involved in seminal immune specific cellular events. Activation through TCR and BCR can have common intracellular pathways while others can be specific for the type of receptor involved or for the specific function triggered. Various PKC isoforms involvement in TCR and BCR Intracellular signaling will be presented as positive and negative regulators of the immune response events triggered in adaptive immunity.

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High, Kevin P. "Immune Senescence." In Molecular Aspects of Aging, 85–97. Hoboken, NJ: John Wiley & Sons, Inc, 2014. http://dx.doi.org/10.1002/9781118396292.ch7.

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Marion, James. "Immunology and the Immune Response." In Molecular Life Sciences, 1–5. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4614-6436-5_648-1.

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Marion, James. "Immunology and the Immune Response." In Molecular Life Sciences, 539–43. New York, NY: Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4614-1531-2_648.

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Konferenzberichte zum Thema "Immune response Molecular aspects"

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Kolubako, A. V., and Y. A. Nikolaichik. "Molecular aspects of Pectobacterium carotovorum – Solanum tuberosum interaction." In 2nd International Scientific Conference "Plants and Microbes: the Future of Biotechnology". PLAMIC2020 Organizing committee, 2020. http://dx.doi.org/10.28983/plamic2020.124.

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Silva, Tarcisio Rubens da, Marina Monteiro Navarro, Mylena Mendes Hóstio, and Catherine Sonaly Ferreira Martins. "Case report - Ataxia-telangiectasia: innate error of immunity and neurological aspects." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.233.

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Introduction: Among more than 350 immunological deficiencies, 25% have neurological manifestations. Thus, Ataxia-telangiectasia stands out, being considered a combined immunodeficiency. In childhood, cerebellar motor findings and recurrent sinopulmonary infections, signaling early cerebellar degeneration and deficit in the combined immune response. It has an autosomal recessive inheritance pattern. Case report: She describes herself as a female patient, 9 years old, daughter of consanguineous parents and born in Sousa, Paraíba. In the child’s neuropsychomotor development, she sat down at 5 mon

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Silva, Gustavo Figueiredo da, Caroline Figueiredo da Silva, Washigton Luiz Gomes de Medeiros Junior, and Marcus Vinícius Magno Gonçalves. "Anti -Iglon5 Syndrome: What we know so far? A non-systematic review." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.237.

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Background: The first report of Anti-IgLON5 syndrome was in 2014. AntiIgLON5 antibodies have a prevalence of 12 in 150,000 patients per year. However, considering the unreported patients, the prevalence can be much higher. Objectives: Provide an overview of the current knowledge of Anti- IgLON5 syndrome. Design and setting: Narrative review. Methods: Non- systematic review on Pubmed database. Results: The IgLON proteins are a family of cell adhesion molecules and the presence of antibodies against IgLON5 is crucial for the AntiIgLON5 Syndrome diagnosis. This syndrome has an expanded clinical s

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Krasnoshtanova, Alla, and Alesya Yudina. "PRODUCTION OF ANTIBODIES FROM POULTRY YOLK (IgY) AND INVESTIGATION OF THEIR IMMUNOCHEMICAL PROPERTIES." In GEOLINKS Conference Proceedings. Saima Consult Ltd, 2021. http://dx.doi.org/10.32008/geolinks2021/b1/v3/17.

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"A particularly important aspect of immunology is to develop non-invasive methods of obtaining antibodies which could be a great alternative to traditional ones that based on the harmful procedure of isolation of immunoglobulins from animal blood sera. That’s why the extraction of antibodies from poultry egg yolks (IgY) is the most promising. Due to the fact of variation of IgY structural features that determine the definite immunochemical properties, yolk antibodies in comparison with mammalian immunoglobulins (IgG) does not interact with rheumatoid factor (Rf), contribute to the activation o

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Aaron, Jesse S., Bryan D. Carson, and Jerilyn Timlin. "Simultaneous, Dual-Color STORM Imaging of Membrane Reorganization during Early Immune Response." In Optical Molecular Probes, Imaging and Drug Delivery. Washington, D.C.: OSA, 2011. http://dx.doi.org/10.1364/omp.2011.oma3.

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Coukos, George. "Abstract KN01: Dissecting antitumor immune response in ovarian cancer." In Abstracts: AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics; October 26-30, 2019; Boston, MA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1535-7163.targ-19-kn01.

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Yang, Ivana V., Laura A. Warg, Elizabeth J. Davidson, Samir N. P. Kelada, Kari Kubalanza, Francis S. Collins, Elissa J. Chesler, et al. "INNATE IMMUNE GENE DISCOVERY USING MACROPHAGE RESPONSE TO PATHOGEN-ASSOCIATED MOLECULAR PATTERNS (PAMPS)." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a1273.

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Shvaratska, Olha, Yuriy Bolbot, and Anna Karpenko. "Some aspects of mucosal immune response in children with bacterial upper respiratory tract infections." In ERS International Congress 2019 abstracts. European Respiratory Society, 2019. http://dx.doi.org/10.1183/13993003.congress-2019.pa1000.

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Lenhardt, Maurício Machado, Dauana Schwartz, and Bruna K. de F. Silva. "Can depression be associated with the immune response." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.443.

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Introduction: Depression is a disease of uncertain installation and etiology, the imbalance of neurotransmitters is involved in this process, and stress can be an activator of pro-inflammatory cytokines and trigger depressive symptoms. The organism undergoes modulations due to biochemical changes and these are linked to molecular and biochemical components and by the survival instinct, the human body is stimulated to release substances as a form of protection. The objective of this study is to describe the possible association between a loss of homeostasis of the central nervous system (CNS),

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Chiaro, Jacopo, Henna Kasanen, Thomas Whalley, Cristian Capasso, Sara Feola, Mikaela Grönholm, Firas Hamdan, et al. "Abstract 1488: Viral molecular mimicry influences the antitumor immune response in murine and human melanoma." In Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-1488.

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Berichte der Organisationen zum Thema "Immune response Molecular aspects"

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Eldar, Avigdor, and Donald L. Evans. Streptococcus iniae Infections in Trout and Tilapia: Host-Pathogen Interactions, the Immune Response Toward the Pathogen and Vaccine Formulation. United States Department of Agriculture, December 2000. http://dx.doi.org/10.32747/2000.7575286.bard.

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In Israel and in the U.S., Streptococcus iniae is responsible for considerable losses in various fish species. Poor understanding of its virulence factors and limited know-how-to of vaccine formulation and administration are the main reasons for the limited efficacy of vaccines. Our strategy was that in order to Improve control measures, both aspects should be equally addressed. Our proposal included the following objectives: (i) construction of host-pathogen interaction models; (ii) characterization of virulence factors and immunodominant antigens, with assessment of their relative importance

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Chejanovsky, Nor, and Bruce A. Webb. Potentiation of pest control by insect immunosuppression. United States Department of Agriculture, July 2004. http://dx.doi.org/10.32747/2004.7587236.bard.

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Our original aims were to elucidate the mechanisms through which the immunosuppressive insect virus, the Campoletis sonorensis polydnavirus (CsV) promotes replication of a well-characterized pathogenic virus, the Autographa californica multiple nucleopolyhedrovirus (AcMNPV) in hosts that are mildly or non-permissive to virus replication. According to the BARD panels criticism we modified our short-term goals (see below). Thus, in this feasibility study (one-year funding) we aimed to show that: 1. S. littoralis larvae mount an immune response against a baculovirus infection. 2. Immunosuppressio

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Cahaner, Avigdor, Susan J. Lamont, E. Dan Heller, and Jossi Hillel. Molecular Genetic Dissection of Complex Immunocompetence Traits in Broilers. United States Department of Agriculture, August 2003. http://dx.doi.org/10.32747/2003.7586461.bard.

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Objectives: (1) Evaluate Immunocompetence-OTL-containing Chromosomal Regions (ICRs), marked by microsatellites or candidate genes, for magnitude of direct effect and for contribution to relationships among multiple immunocompetence, disease-resistance, and growth traits, in order to estimate epistatic and pleiotropic effects and to predict the potential breeding applications of such markers. (2) Evaluate the interaction of the ICRs with genetic backgrounds from multiple sources and of multiple levels of genetic variation, in order to predict the general applicability of molecular genetic marke

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Lamont, Susan J., E. Dan Heller, and Avigdor Cahaner. Prediction of Immunocompetence and Resistance to Disease by Using Molecular Markers of the Major Histocompatibility Complex. United States Department of Agriculture, September 1994. http://dx.doi.org/10.32747/1994.7568780.bard.

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This project utilized two live-animal populations in an integrated research program to identify molecular markers for immune response and disease resistance. The populations each had their foundation from meat-type commercial breeder chicken lines of their respective countries. Investigations effectively used unique availability of resources in each country to study commercial-type environments in Israel and line-crosses with diverse inbred lines in the US. Two bacterial systems were investigated to cover both respiratory and gastrointestinal, and primary and secondary, infections. Individual

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Lillehoj, Hyun, Dan Heller, and Mark Jenkins. Cellular and molecular identification of Eimeria Acervulina Merozoite Antigens eliciting protective immunity. United States Department of Agriculture, November 1992. http://dx.doi.org/10.32747/1992.7561056.bard.

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Coccidiosis, ubiquitous diseases of poultry, seriously impair the growth and feed utilization of livestock and poultry. Coccidiosis causes over $600 million annual losses world-wide and no vaccine is currently available. The goal of this study was to investigate the cellular and molecular mechanisms controlling protective immune responses to coccidia parasites in order to develop immunological control strategy against coccidiosis. The major findings of this study were: 1) cell-mediated immunity plays a major role in protection against coccidiosis, 2) when different genetic lines showing differ

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Banai, Menachem, and Gary Splitter. Molecular Characterization and Function of Brucella Immunodominant Proteins. United States Department of Agriculture, July 1993. http://dx.doi.org/10.32747/1993.7568100.bard.

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The BARD project was a continuation of a previous BARD funded research project. It was aimed at characterization of the 12kDa immunodominant protein and subsequently the cloning and expression of the gene in E. coli. Additional immunodominant proteins were sought among genomic B. abortus expression library clones using T-lymphocyte proliferation assay as a screening method. The 12kDa protein was identified as the L7/L12 ribosomal protein demonstrating in the first time the role a structural protein may play in the development of the host's immunity against the organism. The gene was cloned fro

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Sessa, Guido, and Gregory B. Martin. molecular link from PAMP perception to a MAPK cascade associated with tomato disease resistance. United States Department of Agriculture, January 2012. http://dx.doi.org/10.32747/2012.7597918.bard.

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The research problem: The detection of pathogen-associated molecular patterns (PAMPs) by plant pattern recognition receptors (PRRs) is a key mechanism by which plants activate an effective immune response against pathogen attack. MAPK cascades are important signaling components downstream of PRRs that transduce the PAMP signal to activate various defense responses. Preliminary experiments suggested that the receptor-like cytoplasmickinase (RLCK) Mai5 plays a positive role in pattern-triggered immunity (PTI) and interacts with the MAPKKK M3Kε. We thus hypothesized that Mai5, as other RLCKs, fun

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Gafni, Yedidya, and Vitaly Citovsky. Inactivation of SGS3 as Molecular Basis for RNA Silencing Suppression by TYLCV V2. United States Department of Agriculture, November 2013. http://dx.doi.org/10.32747/2013.7593402.bard.

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The Israeli isolate of Tomato yellow leaf curl geminivirus(TYLCV-Is) is a major tomato pathogen, causing extensive crop losses in Israel and in the south-eastern U.S. Yet, little is known about the molecular mechanisms of its interaction with tomato cells. One of the most interesting aspects of such interaction is how the invading virus counteracts the RNA silencing response of the plant. In the former BARD project, we have shown that TYLCV-Is V2 protein is an RNA silencing suppressor, and that this suppression is carried out via the interaction of V2 with the SGS3 component of the plant RNA s

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McElwain, Terry F., Eugene Pipano, Guy H. Palmer, Varda Shkap, Stephn A. Hines, and Wendy C. Brown. Protection of Cattle against Babesiosis: Immunization against Babesia bovis with an Optimized RAP-1/Apical Complex Construct. United States Department of Agriculture, September 1999. http://dx.doi.org/10.32747/1999.7573063.bard.

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Previous research and current efforts at control of babesiosis fall short of meeting the needs of countries where the disease is endemic, such as Israel, as well as the needs of exporting countries and countries bordering on endemic areas, such as the U.S. Our long-term goal is to develop improved methods of immunization against bovine babesiosis based on an understanding of the molecular mechanisms of immune protection and parasite targets of a protective immune response. In our previous BARD project, we established the basis for focusing on rhoptry antigens as components of a subunit vaccine

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Sessa, Guido, and Gregory Martin. role of FLS3 and BSK830 in pattern-triggered immunity in tomato. United States Department of Agriculture, January 2016. http://dx.doi.org/10.32747/2016.7604270.bard.

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Pattern-recognition receptors (PRRs) located on the plant cell surface initiate immune responses by perceiving conserved pathogen molecules known as pathogen-associated molecular patterns (PAMPs). PRRs typically function in multiprotein complexes that include transmembrane and cytoplasmickinases and contribute to the initiation and signaling of pattern-triggered immunity (PTI). An important challenge is to identify molecular components of PRR complexes and downstream signaling pathways, and to understand the molecular mechanisms that mediate their function. In research activities supported by

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