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Thematische Bibliographien / Immune signalling / Dissertationen

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Dissertationen zum Thema „Immune signalling“

Autor: Grafiati

Veröffentlicht am 25. Mai 2024

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1

Moon, Alice E. "Immune signalling in insect cells." Thesis, Kingston University, 2009. http://eprints.kingston.ac.uk/20407/.

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Immune responses in insects include components and mechanisms that are highly evolutionarily conserved. In addition to providing insight into the insects themselves, knowledge of the conserved mechanisms involved in insect immunity can offer valuable insight that is broadly relevant to a wide variety of other species. Three aspects of insect immune cell signalling have been studied here. Cell signalling responses have been investigated in two insect cell lines following treatment with double stranded (ds) RNA, a common intermediate of viral replication. It has been established that both cell l

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2

Ng, Siaw Wei. "Calcium signalling in immune cells." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:b3843e43-9503-4855-a280-35c0d28f65e6.

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Inappropriate stimulation of mast cells can trigger allergies including asthma, allergic rhinitis and eczema which, combined, affect almost 30% of the population in western societies. Mast cell activation begins with aggregation of IgE receptors in response to antigen. This then triggers a series of reactions resulting in the tyrosine phosphorylation of Syk kinase, PKC activation and ultimately both degranulation and secretion of leukotrienes and cytokines. CRAC channels are expressed on mast cells, and are essential for IgE-mediated mast cell activation. Previous work in our laboratory has sh

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Hamer, Rebecca K. "The structural basis of immune receptor signalling." Thesis, University of Oxford, 2008. http://ora.ox.ac.uk/objects/uuid:32312040-2e22-4fe3-b05e-6f868233e27e.

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This work investigates the mechanisms of binding of T cell receptors (TCRs) to Class I MHC-peptide complexes (pMHC). The structure of a TCR specific for the Melan-A tumour antigen bound to its cognate pMHC was solved to a resolution of 2.5 Å which gives insight into how this TCR could be mutated to optimize binding and subsequently used as a cancer vaccine. Detailed sequence and geometric analyses of all currently available structures of Class I TCR-pMHC complexes revealed that TCRs can bind to pMHC with a range of orientations, yet always focus on the central portion of the peptide and use a

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4

Akha, Amir Akbar Sadighi. "Signalling through the B lymphocyte antigen receptor." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318620.

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5

Morris-Davies, A. C. "Functional analysis of poly-ubiquitin chains in immune signalling." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1383788/.

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NF-κB transcription factors play essential roles in regulating the expression of a large array of genes involved in immune and inflammatory responses, cell proliferation, apoptosis and oncogenesis. In recent years, ubiquitination of key components has emerged as a crucial regulatory mechanism in NF-κB signalling pathways. This can either directly modulate the activity of the target substrate or provide a scaffold for the recognition and recruitment of other signalling molecules via their respective ubiquitin binding domains. NEMO, the regulatory subunit of the IKK complex, is a prime example o

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6

Dawson, Charlotte Helen. "STAT 6 and IL-4 signalling." Thesis, University of Sheffield, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.245716.

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7

Silva, Couto Daniel. "Regulation of receptor kinase-mediated immune signalling by dynamic phosphorylation." Thesis, University of East Anglia, 2015. https://ueaeprints.uea.ac.uk/59391/.

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Plants recognize pathogen-associated molecular patterns (PAMPs) via cell surface-localized pattern recognition receptors (PRRs), initiating a broad-spectrum defense response against pathogens, known as PRR-triggered immunity (PTI). However, immunity comes at a cost; and immune responses need to be tightly regulated. How PTI signalling is negatively regulated in plants is not fully understood. PRRs are present at the plasma membrane in dynamic kinase complexes that heavily rely on trans-phosphorylation to initiate signaling. The Arabidopsis cytoplasmic kinase BIK1 associates with different PRRs

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8

Wahl, Karen. "Role of Notch signalling in the induction of immune responses." Thesis, University of Edinburgh, 2002. http://hdl.handle.net/1842/23239.

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The expression and the role of Notch receptors and ligands during the induction of an immune response were investigated. I have shown that components of the Notch pathway were present in peripheral CD4 and CD8 T cells. Upon culturing and activation <i>in vitro</i>, in many Notch components were differentially expressed, in particular targets of Notch activation. In contrast, bone marrow-derived dendritic cells (DCs) expressed only low levels of Notch targets. However, the Notch ligand Jagged1 was strongly upregulated upon maturation of DCs with TNFα or LPS. By regulating the expression of the

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9

Beyers, Albertus Daniel. "Transmembrane signalling by the CD2 and CD4 molecules of T lymphocytes." Thesis, University of Oxford, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.291324.

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10

Watkinson, Ruth Elizabeth. "Intracellular antibody receptor TRIM21 in viral neutralisation and innate immune signalling." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708305.

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11

Rieser, Eva. "The role of HOIL-1, HOIP and SHARPIN in immune signalling." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/17941.

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Members of the tumour necrosis factor receptor (TNFR) superfamily, the interleukin-1 Receptor (IL-1R), the Toll-like Receptor (TLR) and the NOD-like receptor (NLRs) families play crucial roles in the initiation of innate immune responses. Even though the stimulation of these different receptors is triggered by upstream signalling components which are largely receptor-specific, their signalling cascades generally converge in the activation of both mitogen-activated protein kinases (MAPKs) and the inhibitor of nuclear factor– B (I B) kinases (IKKs). The activation of MAPKs and IKKs are crucial e

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Wyszynski, Rafal Wlodzimierz. "Differential control of immune cell function by HIF-1 signalling pathway." Thesis, University of Kent, 2014. https://kar.kent.ac.uk/47691/.

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Human inflammatory/innate immune responses lie at the core of resistance to infectious disease and determine the nature of pathophysiological reactions of hematopoietic cells like leukaemia and allergy. The crucial step in these events is the ability of immune cells to function properly, which depends on their adaptation to stress caused by pro-inflammatory stimulation. The mechanisms underlying this crucial biochemical dogma, and its role in normal and pathological cross-links between immune cells, are not well understood. This PhD programme was devoted to investigation of these important pro

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Murray, James. "PI 3-kinase : a key effector in C-FMS signalling." Thesis, Open University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264478.

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14

Schreuder, Lisa Jane. "Effects of Mycrobacteria on the Signalling Machinenary of Bovine Innate Immune Cells." Thesis, Royal Veterinary College (University of London), 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.499275.

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15

Banham-Hall, Edward James. "The role of p110[delta] signalling in immune defence against Streptococcus pneumoniae." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708138.

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16

Smith, Emma Marie. "Studies on the role of notch signalling in the adult peripheral immune system." Thesis, Imperial College London, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.497290.

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17

Roberts, Luke Bryan. "The influence of non-neuronal cholinergic signalling on the type 2 immune response." Thesis, Imperial College London, 2016. http://hdl.handle.net/10044/1/56913.

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Acetylcholine (ACh) is synthesised from choline and acetyl-CoA, primarily by the enzyme choline acetyltransferase (ChAT). Traditionally known as a crucial neurotransmitter synthesised and released by neurons of the central and peripheral nervous systems, in recent years there has been an increased interest in the role of ACh synthesised by alternative cells types - particularly those of the haematopoietic immune system. Non-neuronal ACh plays many important roles in the regulation of various immune responses in addition to being associated with the development of a number of disease pathologie

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Jan, Afnan. "A role for connexin signalling in the innate immune response in the skin." Thesis, Glasgow Caledonian University, 2016. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.726766.

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19

Bhandage, Amol K. "Glutamate and GABA signalling components in the human brain and in immune cells." Doctoral thesis, Uppsala universitet, Fysiologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-282422.

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Glutamate and γ-aminobutyric acid (GABA) are the principal excitatory and inhibitory neurotransmitters in the central nervous system (CNS). They both can activate their ionotropic and metabotropic receptors. Glutamate activates ionotropic glutamate receptors (iGlu - AMPA, kainate and NMDA receptors) and GABA activates GABA-A receptors which are modulated by many types of drugs and substances including alcohol. Using real time quantitative polymerase chain reaction, I have shown that iGlu and/or GABA-A receptor subunits were expressed in the hippocampus dentate gyrus (HDG), orbitofrontal cortex

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20

Lo, Yu-Lan (Sandra). "Alternatively Spliced Forms of Tollip Regulate Inflammatory Signalling in Macrophages." Thesis, Griffith University, 2012. http://hdl.handle.net/10072/366923.

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Alternative splicing is one of the mechanisms which drives diversification of innate immune responses. Spliced isoforms of Toll-interacting protein (Tollip), a negative regulator of TLR2-, TLR4- and IL-1R-induced signalling, have been identified to express at endogenous level in human and mouse macrophages. In the current study, we focused on two Tollip isoforms, the full-length Tollip.a and a mouse-specific isoform Tollip.b that lacks the ubiquitin-binding CUE domain. We asked for the effects and consequences of alternative splicing of Tollip in innate immune responses. We wanted to know if a

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Shweash, Muhannad Abdulmajeed Muhammad. "The pathological effects of Leishmania mexicana infection on macrophage cell signalling and immune responses." Thesis, University of Strathclyde, 2010. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=14478.

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22

Fuseya, Yasuhiro. "The HOIL-1L ligase modulates immune signalling and cell death via monoubiquitination of LUBAC." Kyoto University, 2020. http://hdl.handle.net/2433/259006.

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23

Kouroumalis, Andreas. "Characterization of immune receptor-cognate ligands expression and signalling pathways in human intestinal myofibroblasts." Thesis, University of Bath, 2004. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.405156.

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24

Bilkei-Gorzo, Orsolya. "Ubiquitylation regulates vesicle trafficking and innate immune responses on the phagosome of inflammatory macrophages." Thesis, University of Dundee, 2018. https://discovery.dundee.ac.uk/en/studentTheses/8661922d-9d5e-4a4a-bfd4-b0f5e5717c61.

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Macrophages are sentinels present in most tissues of the body, where they recognise and respond to biological dangers. Recognition and uptake of particles is mediated through phagocytic receptors which upon activation induce appropriate responses. These responses need to be tightly regulated in order to destroy pathogens but prevent uncontrolled inflammation. Phagocytosis is an evolutionarily conserved process required for host defence and homeostasis. During phagocytosis, particles are recognised by cell surface receptors that trigger rearrangement of the actin cytoskeleton and internalizatio

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Ayyar, Priya Vijay. "Uncovering the role of S-nitrosylation in jasmonic acid signalling during the plant immune response." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/25783.

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Plants have evolved a plethora of effective mechanisms to protect themselves from biotic stresses. Jasmonates (JAs) are employed as vital defence signals against both insect and pathogen attack. Jasmonic acid (JA) signalling plays a central role in plant defence and development. S-nitrosylation, a redox-based post-translational modification plays an important role in plant disease resistance. S-nitrosoglutathione (GSNO) is formed by the reaction of antioxidant glutathione (GSH) and nitric oxide (NO) and acts as a mobile reservoir of NO bioactivity. The Arabidopsis thaliana S-NITROSOGLUTATHIONE

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Bolukbasi, Ekin. "Characterization of Poly : a novel mediator of insulin receptor signalling in Drosophila." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5700.

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Poly is a novel, essential protein in Drosophila melanogaster, loss of function of which results in late larval lethality. Importantly, Poly is evolutionarily conserved with a human homologue. poly mutation was isolated in a P-element mutagenesis screen that aimed to generate a larger collection of single P-element induced mutants. Mutant poly larvae are characterized by extreme larval longevity without pupation, formation of melanotic masses, smaller imaginal discs and brains, and abnormal nuclear morphology in neuroblasts. During the course of my project, I attempted to identify cellular pro

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Ghaffari, Emma Louise Marie. "Early growth response genes -2 and -3 are essential for optimal immune responses." Thesis, Brunel University, 2013. http://bura.brunel.ac.uk/handle/2438/8134.

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Early Growth Response Genes (EGR) is a family of four transcription factors containing a unique zinc finger domain. EGR-2 and EGR-3 are important for hindbrain development and myelination. These transcription factors are also necessary for lymphocyte function however, the mechanisms are still unclear. Previous findings have shown that EGR-2cKO mice develop lupus-like autoimmune disease with high levels of pro-inflammatory cytokines despite showing normal T and B cell proliferation after mitogenic stimulation. Therefore we established the CD2-EGR-2-/-EGR-3-/- mouse model to explore the phenotyp

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Sotsios, Yannis. "Chemokines and T cells : activation requirements for RANTES secretion and CXCR4 signalling in mature T cells." Thesis, University of Bath, 2000. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323606.

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29

Ehrenberg, Stefanie [Verfasser], and Josef [Akademischer Betreuer] Mautner. "Notch2 signalling in B cell activation, immune response and lymphomagenesis / Stefanie Ehrenberg. Betreuer: Josef Mautner." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2015. http://d-nb.info/1096162849/34.

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30

Cheng, Xiaoxiao. "The nature of protein interactions mediating co-stimulatory signalling in the immune system, involving PD-1." Thesis, University of Oxford, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.600227.

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PD-l , a costimulatory receptor expressed by T -cells, B-cells, NKT cells and monocytes, has emerged as one of the most potent inhibitory molecules in the immune system, and a very promising therapeutic target. The biophysical properties of the interactions of PD-i with its two ligands PD-Lt and PD-L2, however, are incompletely characterized. The question of why there are two ligands for PD-l is also unanswered. An unexpected interaction between PD-Lt and B7- 1, which also binds to other costimulatory receptors, has further complicated the interpretation of the functions of these molecules. In

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Gaughan, Daniel. "The role of DNA damage response proteins in innate immune signalling : a new role for BRCA1." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:252f589f-40c0-4f7f-be3d-124e588e92a8.

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Pattern Recognition Receptors (PRRs), which have evolved to detect a diverse array of pathogenic features known as Pathogen Associated Molecular Patterns (PAMPs), are localised optimally for interaction with their cognate ligands. Upon Receptor activation, signal transduction pathways are induced which converge at different points to direct a specific inflammatory response. TBK1 is activated and recruited to multiple PRRs, where it in turn recruits and phosphorylates IRF3 which then translocates to the nucleus and induces the expression of type I IFN. In this study, the major breast cancer sus

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Thoma, Martine. "Role of IkappaB/NF-kappaB signalling pathways in the immune response of the mosquito Anopheles gambiae." Strasbourg, 2009. https://publication-theses.unistra.fr/restreint/theses_doctorat/2009/THOMA_Martine_2009.pdf.

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Elsheikh, Ayman A. "Drug immunogenicity and co-stimulatory signalling : evidence for formation of a functional antigen through immune cell metabolism." Thesis, University of Liverpool, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.548759.

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34

Bielig, Harald Frank Verfasser], Jonathan [Akademischer Betreuer] Howard, and Mats [Akademischer Betreuer] [Paulsson. "Screening for components involved in NLR-mediated immune signalling / Harald Frank Bielig. Gutachter: Jonathan Howard ; Mats Paulsson." Köln : Universitäts- und Stadtbibliothek Köln, 2012. http://d-nb.info/1038226805/34.

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Bielig, Harald Frank [Verfasser], Jonathan Akademischer Betreuer] Howard, and Mats [Akademischer Betreuer] [Paulsson. "Screening for components involved in NLR-mediated immune signalling / Harald Frank Bielig. Gutachter: Jonathan Howard ; Mats Paulsson." Köln : Universitäts- und Stadtbibliothek Köln, 2012. http://d-nb.info/1038226805/34.

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36

Karsten, Elisabeth. "Red blood cells: the immune system’s hidden regulator, investigation into the role of red blood cells in inflammatory cytokine signalling." Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/16929.

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Red blood cells are the most abundant cell type in mammals, although, they are mostly described as inert carriers of haemoglobin that function only in gas exchange and transport. Evidence is now mounting that these enucleate cells are more complex than previously understood. Studies have reported that red blood cells from healthy individuals regulate immune cell activity and maturation, but red blood cells from inflammatory disease cohorts are dysfunctional. Red blood cells are known to bind a small number of chemokines and have been described as a sink for these molecules, and the loss of thi

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Florey, Oliver John. "Effects of anti-endothlial cell antibodies, immune-complexes and sphingosine-1-phosphate on leukocyte adhesion and cell signalling." Thesis, Imperial College London, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.498233.

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38

Weber, Sabine [Verfasser], and Daniela [Akademischer Betreuer] Männel. "Effects of TNF Receptor Signalling on the the Function of Suppressive Immune Cells / Sabine Weber. Betreuer: Daniela Männel." Regensburg : Universitätsbibliothek Regensburg, 2016. http://d-nb.info/1096751755/34.

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Homem, Rafael Augusto. "Redox signalling and innate immunity : a role for protein S-nitrosylation in the immune response of Drosophila melanogaster." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/15971.

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Over the past three decades, nitric oxide (NO) has been recognised as one of the most versatile and important players in many aspects of physiology, including immune responses. More recently, S-nitrosylation, the incorporation of a NO moiety into a protein thiol group, has emerged as a major post-translational modification (PTM) during pathophysiological responses in plants and animals. The main goal of this work was to investigate the role of S-nitrosylation in physiology and innate immunity of animals using the genetic reference system, Drosophila melanogaster. The S-nitrosylated derivative

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Reder, Gabor. "Development of a phosphoproteomic screen of innate immune signalling : identification and characterisation of a novel phosphorylation of NFkB1/p105." Thesis, Imperial College London, 2010. http://hdl.handle.net/10044/1/6150.

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Toll-like receptors (TLRs) expressed by antigen-presenting cells of the innate immune system, such as macrophages, detect microbial products and activate signalling cascades that initiate specific gene expression programmes that define the subsequent adaptive immune response. However, it is poorly understood how TLR-specific responses arise, as many of the signalling components are common to multiple TLRs, and it is likely that as yet undiscovered phosphorylations of signalling proteins contribute to specificity of TLR pathways. TLR4, the receptor for lipopolysaccharide (LPS), is used as a mod

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ARTUSA, VALENTINA. "Modulation of the Innate Immune Response by Targeting Toll-like Receptor 4 Signalling: Exploring the Role of Natural Products." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2022. http://hdl.handle.net/10281/375443.

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Per secoli, i prodotti naturali e i loro derivati hanno fornito una ricca fonte di composti per lo sviluppo di nuovi immunomodulatori. Gli immunomodulatori naturali possono fornire la chiave per controllare e, infine, sconfiggere i disturbi che colpiscono il sistema immunitario, stimolando o inibendo la risposta immunitaria con pochi effetti collaterali negativi. Molti di questi composti sono attualmente in fase di sperimentazione clinica, in particolare come agenti antiossidanti, antimicrobici e antitumorali. Tuttavia, la funzione e il meccanismo di azione dei prodotti naturali, e il modo in

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Ekholm, Dag. "Cyclic nucleotide signalling systems in vascular smooth muscle cells and immune cells with special reference to phosphodiesterases PDE3 and PDE4." Lund : Lund University, 1998. http://books.google.com/books?id=KPFqAAAAMAAJ.

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Korir, Patricia Jebett [Verfasser]. "Immune regulation in Plasmodium berghei ANKA infected mice either lacking type I interferon signalling or mimicking malaria tolerance / Patricia Jebett Korir." Bonn : Universitäts- und Landesbibliothek Bonn, 2017. http://d-nb.info/1155825454/34.

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Sidwaba, Unathi. "Electrochemical poly(ProDOT) dendritic DNA aptamer biosensor for signalling interferon gamma (IFN-ɣ) TB biomarker". University of the Western Cape, 2017. http://hdl.handle.net/11394/5507.

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Philosophiae Doctor - PhD<br>Tuberculosis (TB) is an infectious disease that, despite all efforts devoted towards its eradication, remains a threat to many countries including South Africa. Current diagnostic assays do offer better performance than the conventional sputum smear microscopy and tuberculin skin tests. However, these assays have been proven to be affected by various factors including the condition of an individual's immune system and vaccination history. By far, electrochemical biosensors are amongst the currently investigated techniques to address the shortcomings associate

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Anselm, Bettina [Verfasser], and Bianca [Akademischer Betreuer] Schaub. "Early priming of the immune system: Identifying predictive markers of innate immunity and calcium signalling for the development of asthma / Bettina Anselm ; Betreuer: Bianca Schaub." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2019. http://d-nb.info/1204827915/34.

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Westphal, Andreas [Verfasser], Kyeong-Hee [Akademischer Betreuer] Lee, Norbert [Akademischer Betreuer] Reiling, and Georgios [Akademischer Betreuer] Tsiavaliaris. "Lysosomal trafficking regulator Lyst controls innate immune cell signalling and function : regulation of TLR-mediated TRIF signalling and control of mast cell-mediated allergic reactions / Andreas Westphal ; Akademische Betreuer: Kyeong-Hee Lee, Norbert Reiling, Georgios Tsiavaliaris ; Institut für Klinische Chemie." Hannover : Bibliothek der Medizinischen Hochschule Hannover, 2017. http://d-nb.info/1143981758/34.

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Käbisch, Romy Astrid [Verfasser], Markus [Akademischer Betreuer] Gerhard, and Dirk [Akademischer Betreuer] Haller. "Effect of Helicobacter pylori infection on dendritic cell maturation, signalling and subsequent adaptive immune response / Romy Astrid Käbisch. Gutachter: Dirk Haller ; Markus Gerhard. Betreuer: Markus Gerhard." München : Universitätsbibliothek der TU München, 2013. http://d-nb.info/1060482630/34.

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Sistigu, Antonella. "Inflammatory and immune reactions in response to chemotherapy-induced cell death. Viral mimicry chemotherapy : ds RNA sensors and IFNAR signalling indispensable for immunogenic tumor cell death." Thesis, Paris 11, 2013. http://www.theses.fr/2013PA11T052.

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Certains motifs moléculaires associés à la mort cellulaire semblent identifier les cancers prompts à répondre à une thérapie cytotoxique. Ceci en élaborant une réponse anti-tumorale basées sur une réponse T protectrice. Mon travail de thèse montre que le traitement par chimiothérapie immunogène active des voies moléculaires mimant une infection virale. Ceci conduit au niveau des cellules tumorales à une signalisation autocrine via l’IFNαβ / IFNAR1/2, initiée par la reconnaissance d’ARN double brin (dsRNA) endogène par les Récepteurs endosomaux de Reconnaissance des Motifs (PRRs). De façon plus

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Lambourne, Jonathan Richard. "An investigation of human immune signalling pathways during Staphylococcus aureus colonisation and bacteraemia leading to an investigation of mannose-binding lectin in S. aureus bacteraemia, chronic hepatitis and acute aspergillosis." Thesis, St George's, University of London, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.546773.

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Zmarlak, Natalia Marta. "Regulation of immune signalling in the malaria mosquito vector, Anopheles : the secreted mosquito leucine-rich repeat protein APL1C is a pathogen binding factor essential for immunity to Plasmodium ookinetes and sporozoites." Electronic Thesis or Diss., Sorbonne université, 2021. http://www.theses.fr/2021SORUS053.

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Annotation:

L’anophèle est le moustique vecteur du parasite Plasmodium, responsable du paludisme. Chez ce moustique, des protéines de type LRR (à motifs riches en leucine) ont été décrites comme antagonistes cruciaux du développement de Plasmodium. L’une d’entre elles, APL1C (Anopheles Plasmodium-responsive factor) protège spécifiquement le moustique contre les parasites Plasmodium de rongeurs en collaboration avec la protéine TEP1 du complément. En combinant des approches de biologie cellulaire et de génomique fonctionnelle, mon travail de thèse montre que le repas sanguin des moustiques induit le recrut

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