Thematische Bibliographien / Individualized treatment regime

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Auswahl der wissenschaftlichen Literatur zum Thema „Individualized treatment regime“

Autor: Grafiati

Veröffentlicht am 23. November 2024

Zuletzt aktualisiert am 31. Juli 2025

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Zeitschriftenartikel zum Thema "Individualized treatment regime"

최영근. "Individualized Treatment Regime for Personalized Medicine: A Review." Quantitative Bio-Science 36, no. 1 (2017): 7–13. http://dx.doi.org/10.22283/qbs.2017.36.1.7.

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Huang, Xinyang, Yair Goldberg, and Jin Xu. "Multicategory individualized treatment regime using outcome weighted learning." Biometrics 75, no. 4 (2019): 1216–27. http://dx.doi.org/10.1111/biom.13084.

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Marques, Lara, and Nuno Vale. "Improving Individualized Salbutamol Treatment: A Population Pharmacokinetic Model for Oral Salbutamol in Virtual Patients." Pharmaceutics 17, no. 1 (2024): 39. https://doi.org/10.3390/pharmaceutics17010039.

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Background: Salbutamol, a short-acting β2-agonist used in asthma treatment, is available in multiple formulations, including inhalers, nebulizers, oral tablets, and intravenous, intramuscular, and subcutaneous routes. Each formulation exhibits distinct pharmacokinetic (PK) and pharmacodynamic (PD) profiles, influencing therapeutic outcomes and adverse effects. Although asthma management predominantly relies on inhaled salbutamol, understanding how these formulations interact with patient-specific characteristics could improve personalized medicine approaches, potentially uncovering the therape

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Feshchenko, Yu I., N. A. Litvinenko, N. V. Grankina, et al. "Treatment of patients with multidrugresistant and extensively drug resistant tuberculosis depending on the composition of individualized regimens: immediate and longterm results." Tuberculosis, Lung Diseases, HIV Infection, no. 4 (December 15, 2021): 7–15. http://dx.doi.org/10.30978/tb2021-4-7.

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Objective — to study the effectiveness of treatment of MDR-TB (multidrug-resistant tuberculosis) and preXDR-TB/XDR-TB (pre-extensively and extensively drug resistant tuberculosis), depending on the composition of ITRs (individualized treatment regimens). Materials and methods. Тhe prospective observational study included 566 patients with MDR/preXDR-TB and XDR-TB during 2016—2020 on the scientific clinical bases of the SI «National Institute of Phthisiology and Pulmonology named after F.G. Yanovsky NAMS of Ukraine» and ME «Kryvyi Rih Anti-tuberculosis Dispensary» Dnipropetrovsk Regional

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Frommeyer, Timothy C., Michael M. Gilbert, Reid M. Fursmidt, et al. "Reinforcement Learning and Its Clinical Applications Within Healthcare: A Systematic Review of Precision Medicine and Dynamic Treatment Regimes." Healthcare 13, no. 14 (2025): 1752. https://doi.org/10.3390/healthcare13141752.

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Background/Objectives: Reinforcement learning (RL), a subset of machine learning, has emerged as a promising tool for supporting precision medicine and dynamic treatment regimes by enabling adaptive, data-driven clinical decision making. Despite its potential, challenges such as interpretability, reward definition, data limitations, and clinician adoption remain. This review aims to evaluate the recent advancements in RL in precision medicine and dynamic treatment regimes, highlight clinical fields of application, and propose practical frameworks for future integration into medical practice. M

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Rich, Benjamin, Erica E. M. Moodie, and David A. Stephens. "Influence Re-weighted G-Estimation." International Journal of Biostatistics 12, no. 1 (2016): 157–77. http://dx.doi.org/10.1515/ijb-2015-0015.

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Abstract Individualized medicine is an area that is growing, both in clinical and statistical settings, where in the latter, personalized treatment strategies are often referred to as dynamic treatment regimens. Estimation of the optimal dynamic treatment regime has focused primarily on semi-parametric approaches, some of which are said to be doubly robust in that they give rise to consistent estimators provided at least one of two models is correctly specified. In particular, the locally efficient doubly robust g-estimation is robust to misspecification of the treatment-free outcome model so

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Olivieri, Martin, Christoph Königs, Christine Heller, et al. "Prevalence of Obesity in Young Patients with Severe Haemophilia and Its Potential Impact on Factor VIII Consumption in Germany." Hämostaseologie 39, no. 04 (2019): 355–59. http://dx.doi.org/10.1055/s-0039-1677874.

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AbstractSimilar to the general population, overweight and obesity have increasingly become a medical and economic burden also in patients with haemophilia in industrialized nations. In this study in seven German haemophilia centres, we identified a prevalence of overweight and obesity of 25.2% among 254 young patients <30 years (median: 13 years; range: 0–30 years) with severe haemophilia A and without a history of inhibitors. The median FVIII dosage based on bodyweight was significantly higher in normal weight compared with overweight or obese patients (96.9 vs. 72.9 IU/kg/week, respective

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Bidu, Nadielle S., Bruno J. D. Fernandes, Eduardo J. C. Dias, et al. "Vancomycin Therapeutic Regime Adjustment in Newborns and Infants with Bacterial Infection: Case Series." Current Pharmaceutical Biotechnology 20, no. 4 (2019): 346–51. http://dx.doi.org/10.2174/1389201020666190319161511.

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Background: Vancomycin is used mostly to overcome infections caused by methicillinresistant microorganisms. There are no well-established administration protocols for neonates and infants, so the leak of a specific administration regime in that population may lead to serum concentrations beyond the specified range. Objective: This case series evaluated the pharmacokinetics adjustment from a vancomycin therapeutic regimen prescribed to neonates and infants with bacterial infection at a neonatal public hospital intensive- care-unit, with the primary purpose to verify cases of nephrotoxicity. Met

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Hoffmann, Christian, Toke Ringbaek, Anja Eckstein, et al. "Long-Term Follow-Up of Patients with Conjunctival Lymphoma after Individualized Lens-Sparing Electron Radiotherapy: Results from a Longitudinal Study." Cancers 15, no. 22 (2023): 5433. http://dx.doi.org/10.3390/cancers15225433.

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Irradiation with electrons is the primary treatment regime for localized conjunctival low-grade lymphomas. However, radiation-induced cataracts are a major cause of treatment-related morbidity. This study investigates whether lens-sparing electron irradiation produces sufficient disease control rates while preventing cataract formation. All consecutive patients with strictly conjunctival, low-grade Ann Arbor stage IE lymphoma treated with superficial electron irradiation between 1999 and 2021 at our department were reviewed. A total of 56 patients with 65 treated eyes were enrolled with a medi

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Zhang, Jianzhong, ChaoZhao Liang, Xuejun Shang, and Hongjun Li. "Chronic Prostatitis/Chronic Pelvic Pain Syndrome: A Disease or Symptom? Current Perspectives on Diagnosis, Treatment, and Prognosis." American Journal of Men's Health 14, no. 1 (2020): 155798832090320. http://dx.doi.org/10.1177/1557988320903200.

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Definitive diagnosis and selection of effective treatment for chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) are frustrations encountered frequently by urology care providers in their practice. Knowledge of etiology and pathophysiology is not sufficient and therapeutic guidelines have not yielded acceptable outcomes and prognoses for both patients and care providers. The authors present updated perspectives on CP/CPPS, including definition, diagnosis, treatment, and prognosis, based on literature review and clinical experience. A key point is to shift the diagnostic and therapeutic

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Dissertationen zum Thema "Individualized treatment regime"

Yazzourh, Sophia. "Apprentissage par renforcement et outcome-weighted learning bayésien pour la médecine de précision : Intégration de connaissances médicales dans les algorithmes de décision." Electronic Thesis or Diss., Université de Toulouse (2023-....), 2024. http://www.theses.fr/2024TLSES139.

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La médecine de précision vise à adapter les traitements aux caractéristiques de chaque patient en s'appuyant sur les formalismes des "Individualized Treatment Regimes" (ITR) et des "Dynamic Treatment Regimes" (DTR). Les ITR concernent une seule décision thérapeutique, tandis que les DTR permettent l'adaptation des traitements au fil du temps via une séquence de décisions. Pour être pertinentes, ces approches doivent être en mesure de traiter des données complexes et d'intégrer les connaissances médicales, essentielles pour permettre une utilisation clinique réaliste et sans risques. Cette thès

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Bücher zum Thema "Individualized treatment regime"

Thakur, Siddarth, and Salahadin Abdi. Cervical Spine. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190626761.003.0007.

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Pain emanating from the cervical spine represents a significant diagnostic and therapeutic challenge for clinicians. The precise etiology of the pain may be difficult to identify because there are many potential pain-generating structures in the cervical spine and surrounding region. It is helpful to delineate the patient’s symptoms as axial- or radicular-predominant in order to guide the investigation prior to initiating treatment. The evidence for many commonly used treatment regimens is variable, and therefore an individualized plan is often necessary. Although it is conceptually accommodat

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Buchteile zum Thema "Individualized treatment regime"

Zhou, Wenzhuo, Yuhan Li, and Ruoqing Zhu. "Policy Learning for Individualized Treatment Regimes on Infinite Time Horizon." In ICSA Book Series in Statistics. Springer International Publishing, 2024. http://dx.doi.org/10.1007/978-3-031-50690-1_4.

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Jones, Roger D., and Alan M. Jones. "A Proposed Mechanism for in vivo Programming Transmembrane Receptors." In Communications in Computer and Information Science. Springer Nature Switzerland, 2024. http://dx.doi.org/10.1007/978-3-031-57430-6_11.

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AbstractTransmembrane G-protein coupled receptors (GPCRs) are ideal drug targets because they resemble, in function, molecular microprocessors for which outcomes (e.g. disease pathways) can be controlled by inputs (extracellular ligands). The inputs here are ligands in the extracellular fluid and possibly chemical signals from other sources in the cellular environment that modify the states of molecular switches, such as phosphorylation sites, on the intracellular domains of the receptor. Like in an engineered microprocessor, these inputs control the configuration of output switch states that

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Merlo, Gia. "Substance Use Disorders and the Impaired Physician." In Principles of Medical Professionalism. Oxford University Press, 2021. http://dx.doi.org/10.1093/med/9780197506226.003.0012.

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Patient safety is jeopardized when healthcare services are provided by physicians who suffer from substance use disorders (SUDs). When focusing on the problem of substance abuse and dependence among physicians, certain factors inherent in the medical field, such as long hours, the high-stress nature of the work, and the ease of access to drugs, make physicians more susceptible to abusing or becoming dependent on prescription drugs and alcohol. SUDs may differ in severity. The fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (Washington, DC: American Psychiatric Associ

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Bartlett, John G., Robert R. Redfield, and Paul A. Pham. "Antiretroviral Therapy." In Bartlett's Medical Management of HIV Infection. Oxford University Press, 2019. http://dx.doi.org/10.1093/med/9780190924775.003.0004.

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Abstract: This chapter is about antiretroviral therapy (ART). It includes the goals of antiretroviral therapy (according to the 2018 Department of Health and Human Services [DHHH] guidelines), and it covers recommendations for antiretroviral therapy, special co-factor considerations, and what antiretroviral regimen to start. The chapter includes a detailed discussion on the selection of the initial third ART drug, individualized selection of the initial regimen, initiating ART in a patient with HIV-associated complications, treatment of HIV-2 infection, factors that influence the probability o

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Gottschalk, Christopher, Alan M. Rapoport, and Mark J. Rapoport. "Pharmacological Treatment of Acute Migraine." In Comprehensive Review of Headache Medicine, 2nd ed., edited by Morris Levin. Oxford University PressNew York, 2025. https://doi.org/10.1093/med/9780190888770.003.0017.

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Abstract Acute abortive therapy is the backbone of headache treatment. Every migraine patient, no matter how rare or how frequent their attacks, needs an acute treatment regimen, and each patient deserves optimized, individualized therapy. Optimal acute therapy reduces short-term disability, the risk of recurrence, and likely, the risk of disease progression. Recognizing that regular use of highly effective abortive therapy can reduce the burden of migraine in the long term, can be a life-changing step for patients and clinicians alike. This chapter reviews strategies for optimizing the acute

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Chudakova, Tatiana. "“Treating Not the Illness, but the Patient”." In Mixing Medicines. Fordham University Press, 2021. http://dx.doi.org/10.5422/fordham/9780823294312.003.0005.

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Chapter four follows Tibetan medicine into the clinic. It tracks patients and practitioners’ strategies of managing health in a clinical space that offers a mixture of therapeutic interventions and leaves the body radically open-ended. Here, Tibetan medicine is made to align with older rationales of Soviet-era biomedicine about health being the direct condensation of detrimental and beneficial environmental exposures, and the ailing body becomes narrated as an accumulation of collective pathogenic time, which these treatment regimes aim to redress or revert. Tracking how patients and doctors n

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"Insulin Administration and Use Considerations." In Practical Insulin: A Handbook for Prescribing Providers. American Diabetes Association, 2023. http://dx.doi.org/10.2337/9781580407632.ch04.

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When selecting an individualized insulin regimen for a person with diabetes, there are a variety of factors to consider. Such factors include, but are not limited to cost and access considerations, self-management capabilities, and person-specific treatment goals. On a product level, individual insulin products are available in a variety of different delivery devices and have different recommendations for storage and use. Table 3 provides a summary of current insulin product availability and storage recommendations from the manufacturers. This section will discuss several insulin use considera

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Ali, Asad, Zeeshan Ahmad, Usama Ahmad, Mohd Muazzam Khan, Md Faheem Haider, and Juber Akhtar. "Integrating Nanotherapeutic Platforms to Image Guided Approaches for Management of Cancer." In Molecular Pharmacology. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.94391.

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Cancer is a leading cause of mortality worldwide, accounting for 8.8 million deaths in 2015. The landscape of cancer therapeutics is rapidly advancing with development of new and sophisticated approaches to diagnostic testing. Treatment plan for early diagnosed patients include radiation therapy, tumor ablation, surgery, immunotherapy and chemotherapy. However the treatment can only be initiated when the cancer has been diagnosed thoroughly. Theranostics is a term that combines diagnostics with therapeutics. It embraces multiple techniques to arrive at comprehensive diagnosis, molecular images

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Garg, Tushar. "DOTS-Plus." In 50 Studies Every Global Health Provider Should Know, edited by Andrea Walker, Anup Agarwal, and Yogesh Jain. Oxford University PressNew York, 2023. http://dx.doi.org/10.1093/med/9780197548721.003.0009.

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Abstract Multidrug-resistant tuberculosis (TB) is a major issue in global health, prompting concerns from multilateral agencies and donor organizations about the ability of low- and middle-income countries (LMICs) to effectively treat patients with this disease as a result of poor health infrastructure and the perceived inability to ensure that patients receive and take their specialized antibiotic regimens. The DOTS-Plus program for patients with drug-resistant TB described in this study provides individualized, patient-centered care in a community-based, outpatient, and low-resource environm

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Udalov Yuri D., Vasilyeva Irina V., Gordienko Alexander V., and Bakharev Sergey A. "Model of Decision Making Support for a Doctor in the Treatment of an Oncosurgical Patient in a Hospital." In Studies in Health Technology and Informatics. IOS Press, 2018. https://doi.org/10.3233/978-1-61499-921-8-122.

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At the present moment, there is no uniform approach to the decision to conduct a planned surgical intervention in case of oncosurgical pathology, with appropriate recommendations in different sources. Consequently, in modern medicine, there is a particular problem of an objective assessment of the patient's physical condition and a risk assessment of an upcoming surgical intervention for developing an individualized tactic of preparation for surgical treatment for each particular patient. The need for introduction of new approaches and technologies, as well as treatment regimens, that allow us

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Konferenzberichte zum Thema "Individualized treatment regime"

Brown, Erika, Marshall Pickarts, Jose Delgado-Linares, et al. "Scale-Up and Modeling Efforts Using an Omniphobic Surface Treatment for Mitigating Solids Deposition." In Offshore Technology Conference. OTC, 2022. http://dx.doi.org/10.4043/32059-ms.

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Abstract Gas hydrates, waxes and asphaltenes represent some of the most significant flow assurance challenges, especially in subsea lines, where treatment options can be limited. Currently, complete avoidance is the primary strategy for hydrate management, while chemical or mechanical flushing/pigging may be utilized for other solids. Each system must also be treated with individualized solutions, as there have been no proved one-size-fits-all technologies demonstrated to date. As an alternative to constant chemical injection or thermodynamic controls such as insulation or heating, a robust om

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Saha, Avinandan, Preyas J. Vaidya, Vinod B. Chavhan, et al. "Factors affecting outcomes of individualised treatment for drug resistant tuberculosis in an endemic region>." In ERS International Congress 2017 abstracts. European Respiratory Society, 2017. http://dx.doi.org/10.1183/1393003.congress-2017.pa2728.

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Liao, Chih-Yi, Benny Johnson, Alexander Spira, et al. "660 Clinicopathologic characteristics of patients with metastatic colorectal cancer with molecular responses following treatment with an individualized neoantigen vaccine regimen." In SITC 37th Annual Meeting (SITC 2022) Abstracts. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/jitc-2022-sitc2022.0660.

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Yatskevich, N., H. Hurevich, V. Solodovnikova, et al. "Preliminary data on safety and effectiveness of six-month all-oral regimens in patients with rifampicin-resistant tuberculosis in Belarus." In MSF Scientific Day International 2023. MSF-USA, 2023. http://dx.doi.org/10.57740/6r4t-kf45.

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INTRODUCTION The total duration of treatment for rifampicin-resistant tuberculosis (RR-TB) in Belarus prior to December 2022 was 18-20 months. The efficacy of treatment with such regimens is low, with the WHO’s Global TB Report suggesting that efficacy was around 73% in Belarus in 2018. The development of effective short regimens for RR-TB treatment is urgent. In Belarus, six-month long treatment with all-oral regimens is used in patients with RR-TB, under operational research conditions, following WHO recommendations. METHODS A preliminary assessment of the effectiveness of six-month all-oral

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Lichtenfels, Martina, Vivian Fontana, Bianca Silva Marques, Francine Hickmann Nyland, and José Luiz Pedrini. "The role of tumor resistance in neoadjuvant chemotherapy: efficacy of a novel in vitro breast cancer chemoresistance platform to demonstrate high resistance patterns in residual disease." In XXVI Brazilian Mastology Congress. Mastology, 2024. https://doi.org/10.29289/259453942024v34s2041.

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Introduction: Functional precision medicine is an innovative treatment strategy in which drugs are tested on the patient’s cancer cells cultured outside the body. It is a powerful method to understand tumor resistance and match the most appropriate treatment to the patient. Previous literature showed that patients with blood and brain cancer live longer when their chemotherapy regimens are guided by functional drug testing compared to their experiences of standard treatments. Some methods are already available worldwide, offering personalized drug testing services; however, in Brazil, no in vi

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Castilho, Manoel Olavo Valentim Fernandes de, Karen Tamires Viau, Tulio Avelar Ferreira, Ana Luísa Bacile Katsui, Emilly Anne Teixeira Pereira, and Lucas Fernando da Silva Moraes. "Enucleation of a large meroblastic fibroma: Case report." In IV Seven International Congress of Health. Seven Congress, 2024. http://dx.doi.org/10.56238/homeivsevenhealth-034.

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Although ameloblastic fibroma is a benign neoplasm, it has considerable rates of recurrence and malignant transformation into an ameloblastic fibrosarcoma. In this context, we seek to provide important information on the clinical presentation, diagnosis and treatment of this rare and challenging tumor. To this end, we present a case report of a 24-year-old patient with an asymptomatic increase in volume in the left mandibular region together with a panoramic X-ray showing a multilocular radiolucent area involving the mandibular ramus, angle and body associated with an included element 47. The

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Lichtenfels, Martina, Mário Casales Schorr, Isis Mendes Barbosa, Caroline Brunetto de Farias, and José Luiz Pedrini. "A novel in vitro breast cancer chemoresistance platform." In XXVI Brazilian Mastology Congress. Mastology, 2024. https://doi.org/10.29289/259453942024v34s2042.

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Introduction: Breast cancer (BC) is a highly heterogeneous disease characterized by distinct molecular subtypes and prognoses. Tumor resistance is the main cause of treatment failure, leading to cancer progression. Despite the knowledge of different drug resistance mechanisms in BC cells, overcoming resistance is still challenging. Therefore, predicting resistance before initiating chemotherapy is valuable for increasing treatment benefits. Functional precision medicine is an innovative treatment strategy in which drugs are tested on the patient’s cancer cells, cultured outside the body, to un

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LeBrun, Alexander, Ronghui Ma, and Liang Zhu. "Tumor Shrinkage Study in Magnetic Nanoparticle Hyperthermia Based on Designed Heating Protocols." In ASME 2016 5th International Conference on Micro/Nanoscale Heat and Mass Transfer. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/mnhmt2016-6559.

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Magnetic nanoparticle hyperthermia has attracted growing attentions recently due to its ability of confining nanoparticle-induced heating in targeted tumor region. Our recent studies have identified an injection strategy to achieve repeatable and controllable nanoparticle deposition patterns in PC3 tumors using microCT scans. Based on the injection strategy, simulation of temperature elevations in tumors is conducted to design heating protocols to induce irreversible thermal damage to the entire tumors. In this study, in vivo heating experiments are performed on PC3 tumors implanted on mice fo

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Neto, Eclésio Batista de Oliveira, Gabriela Leite Almeida Costa, Edson Santana Gois Filho, João Deon de Araújo Filho, and Daniele Gonçalves Bezerra. "NEUROCISTICERCOSE SUBARACNOIDE: TRATAMENTO FARMACOLÓGICO." In II Congresso Brasileiro de Parasitologia Humana On-line. Revista Multidisciplinar em Saúde, 2022. http://dx.doi.org/10.51161/conbrapah/6.

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Introdução: A Neurocisticercose (NC) é causada pela infecção do cérebro por metacestódeos da Taenia solium. Os sintomas encontrados geralmente são: dor de cabeça, convulsões, confusão mental e coma. Entretanto, os sinais e sintomas variam de acordo com o tamanho do cisto, localização, número e grau de inflamação. A Neurocisticercose subaracnoide (NCS) é causada por uma forma proliferativa anatomicamente anormal de cisto da T. solium. Em comparação com cistos estruturados normais, que têm a estrutura anatômica típica de metacestódeos com o escólex invaginado em sua bexiga. Os cistos relacionado

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