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1

Puzuka, Agrita, Baiba Alksere, Linda Gailite, and Juris Erenpreiss. "Idiopathic Infertility as a Feature of Genome Instability." Life 11, no. 7 (June 29, 2021): 628. http://dx.doi.org/10.3390/life11070628.

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Genome instability may play a role in severe cases of male infertility, with disrupted spermatogenesis being just one manifestation of decreased general health and increased morbidity. Here, we review the data on the association of male infertility with genetic, epigenetic, and environmental alterations, the causes and consequences, and the methods for assessment of genome instability. Male infertility research has provided evidence that spermatogenic defects are often not limited to testicular dysfunction. An increased incidence of urogenital disorders and several types of cancer, as well as
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Baszyński, Jędrzej, Piotr Kamiński, Maria Bogdzińska, Sławomir Mroczkowski, Marek Szymański, Karolina Wasilow, Emilia Stanek, et al. "Enzymatic Antioxidant Defense and Polymorphic Changes in Male Infertility." Antioxidants 11, no. 5 (April 22, 2022): 817. http://dx.doi.org/10.3390/antiox11050817.

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The intensification of oxidative stress and destabilization of the antioxidative defenses of an organism is a consequence of many environmental factors. We considered aspects conditioning male reproductive potential and the functionality of enzymatic antioxidative mechanisms, i.e., superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR), and their correlations with Li, Be, B, Na, Mg, Al, P, K, Ca, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Se, Sr, Mo, Ag, Cd, Sn, Sb, Ba, Hg, Tl, Pb, and malondialdehyde (MDA), as well as genetic polymorphism IL-4v.C58
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Leshchenko, O. Ya, E. V. Genich, M. A. Darenskaya, and L. I. Kolesnikova. "HIV and infertility: neuro-endocrine and metabolic aspects." HIV Infection and Immunosuppressive Disorders 12, no. 4 (February 9, 2021): 73–80. http://dx.doi.org/10.22328/2077-9828-2020-12-4-73-80.

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Objective: to establish a correlation of the main neuroendocrine and metabolic parameters associated with infertility and to provide a prognostic assessment of reproductive disorders in HIV-infected women, stages 4.Materials and methods. Cross-sectional, cohort, clinical and sociological study of fertility of 83 women of reproductive age with HIV, stages 4.Results. The most significant indicators of lipid peroxidation and neuroendocrine regulation systems have been established in patients with HIV infection and reproductive disorders, which will make it possible to predict these disorders in th
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4

Coccia, Maria Elisabetta, Luca Nardone, and Francesca Rizzello. "Endometriosis and Infertility: A Long-Life Approach to Preserve Reproductive Integrity." International Journal of Environmental Research and Public Health 19, no. 10 (May 19, 2022): 6162. http://dx.doi.org/10.3390/ijerph19106162.

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Laparoscopic surgery was originally considered the gold standard in the treatment of endometriosis-related infertility. Assisted reproductive technology (ART) was indicated as second-line treatment or in the case of male factor. The combined approach of surgery followed by ART proved to offer higher chances of pregnancy in infertile women with endometriosis. However, it was highlighted how pelvic surgery for endometriosis, especially in cases of ovarian endometriomas, could cause iatrogenic damage due to ovarian reserve loss, adhesion formation (scarring), and ischemic damage. Furthermore, in
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Medenica, Sanja, Dusan Zivanovic, Ljubica Batkoska, Susanna Marinelli, Giuseppe Basile, Antonio Perino, Gaspare Cucinella, Giuseppe Gullo, and Simona Zaami. "The Future Is Coming: Artificial Intelligence in the Treatment of Infertility Could Improve Assisted Reproduction Outcomes—The Value of Regulatory Frameworks." Diagnostics 12, no. 12 (November 28, 2022): 2979. http://dx.doi.org/10.3390/diagnostics12122979.

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Infertility is a global health issue affecting women and men of reproductive age with increasing incidence worldwide, in part due to greater awareness and better diagnosis. Assisted reproduction technologies (ART) are considered the ultimate step in the treatment of infertility. Recently, artificial intelligence (AI) has been progressively used in the many fields of medicine, integrating knowledge and computer science through machine learning algorithms. AI has the potential to improve infertility diagnosis and ART outcomes estimated as pregnancy and/or live birth rate, especially with recurre
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Akhtar, Shamim, Rizwana Nasreen, Humaira Bibi, Ayesha Azhar Khan, Asma Amin Baig, and Najia Riffat. "Reproductive Features of Patients with Secondary Infertility." Pakistan Journal of Medical and Health Sciences 16, no. 10 (October 30, 2022): 111–12. http://dx.doi.org/10.53350/pjmhs221610111.

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Background: Childlessness is a very pain full situation. It affects both partners but more to females. Burden of secondary infertility is more than primary infertility but it is not captured properly. Secondary infertility also has significant psychological, personal and marital sufferings. Social pressures add the anxiety if only daughters are born. Aim: To find out the reproductive characteristic features of patients presenting with secondary infertility. Place and duration: This retrospective cross sectional study was conducted in Health Care Center Hospital (Pvt) Ltd from July 2021 to Sept
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7

Zańko, Adrianna, Katarzyna Siewko, Adam Jacek Krętowski, and Robert Milewski. "Lifestyle, Insulin Resistance and Semen Quality as Co-Dependent Factors of Male Infertility." International Journal of Environmental Research and Public Health 20, no. 1 (December 30, 2022): 732. http://dx.doi.org/10.3390/ijerph20010732.

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Infertility is a problem that affects millions of couples around the world. It is known as a disease of couples, not individuals, which makes diagnosis difficult and treatment unclear. Male infertility can have many causes, from mechanical ones to abnormal spermatogenesis or spermiogenesis. Semen quality is determined by a number of factors, including those dependent on men themselves, with the number of infertile men growing every year. These include, e.g., diet, physical activity, sleep quality, stress, among many others. As these factors co-exist with insulin resistance, which is a disease
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8

Hall, Julie M., and Callie W. Greco. "Perturbation of Nuclear Hormone Receptors by Endocrine Disrupting Chemicals: Mechanisms and Pathological Consequences of Exposure." Cells 9, no. 1 (December 19, 2019): 13. http://dx.doi.org/10.3390/cells9010013.

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Much of the early work on Nuclear Hormone Receptors (NHRs) focused on their essential roles as mediators of sex steroid hormone signaling in reproductive development and function, and thyroid hormone-dependent formation of the central nervous system. However, as NHRs display tissue-specific distributions and activities, it is not surprising that they are involved and vital in numerous aspects of human development and essential for homeostasis of all organ systems. Much attention has recently been focused on the role of NHRs in energy balance, metabolism, and lipid homeostasis. Dysregulation of
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9

Lyaginskaya, Antonina M., I. M. Petoyan, A. P. Ermalitskiy, V. V. Kuptsov, and N. M. Karelina. "RADIATION-HYGIENIC ASPECTS OF REPRODUCTIVE HEALTH IN MALES OF THE STAFF OF THE NUCLEAR POWER PLANT." Hygiene and sanitation 96, no. 9 (March 27, 2019): 883–87. http://dx.doi.org/10.18821/0016-9900-2017-96-9-883-887.

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The aim of this study was a retrospective evaluation of the reproductive health of the male staff of the Kalinin and Kursk nuclear power plant (NPP). Material and Methods. Fertility indices were used for the evaluation of the reproductive health status (ability to have children) and the health status of their offspring. For the assessment of the fertility there were used data concerning the marital status, childbirths and radiation doses received by males, obtained from the questionnaires, developed as part of this study. The data about the health of newborns was obtained from information copi
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Borovkova, Violetta V., Aleksandr V. Zubko, Tamara P. Sabgayda, Konstantin E. Khomanov, and Gleb S. Krasnov. "The opinion of the medical community on the legal issues of surrogate maternity." HEALTH CARE OF THE RUSSIAN FEDERATION 66, no. 1 (March 4, 2022): 76–84. http://dx.doi.org/10.47470/0044-197x-2022-66-1-76-84.

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Introduction. Surrogacy is a method of infertility treatment involving the conclusion of an agreement between potential parents, a surrogate mother and a medical institution. Until now, lawyers have not been able to develop a unified approach to forming the regulatory framework for surrogacy. Whether healthcare providers have developed a standard view of this problem is not clear. The purpose is to summarise the medical community representatives’ views on the surrogacy program’s managing issues and their participants’ rights and obligations. Material and methods. The Internet survey was conduc
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Druzhinina, N. K., and E. А. Korovyakova. "MALE INFERTILITY. GENETIC ASPECTS." Bulletin "Biomedicine and sociology" 3, no. 4 (December 30, 2018): 49–51. http://dx.doi.org/10.26787/nydha-2618-8783-2018-3-4-49-51.

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12

Pizzol, Damiano, Alessandro Bertoldo, and Carlo Foresta. "Male infertility: biomolecular aspects." Biomolecular Concepts 5, no. 6 (December 1, 2014): 449–56. http://dx.doi.org/10.1515/bmc-2014-0031.

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AbstractMale infertility is a problem that faces increasing interest, and the continuous development of assisted reproduction techniques solicits attempts to identify a precise diagnosis, in particular for idiopathic infertile couples and those undergoing assisted reproductive technique cycles. To date, diagnosis of male infertility is commonly based on standard semen analysis, but in many cases, this is not enough to detect any sperm abnormality. A better understanding of biomolecular issues and mechanism of damaged spermatogenesis and the refinement of the molecular techniques for sperm eval
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13

Burnett, Arthur L., Natalie C. Edwards, Tonya M. Barrett, Krista D. Nitschelm, and Samir K. Bhattacharyya. "Addressing Health-Care System Inequities in the Management of Erectile Dysfunction: A Call to Action." American Journal of Men's Health 14, no. 5 (September 2020): 155798832096507. http://dx.doi.org/10.1177/1557988320965078.

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Erectile dysfunction (ED) is a common, burdensome, and costly urologic condition strongly related to all aspects of general health, from physical to mental. ED has profound consequences as it may interfere physical well-being, quality of life (QoL), self-esteem, relationships, self-worth, and productivity. It is therefore important to ensure that all types of effective ED treatments are consistently accessible to patients. While federal and state mandates ensure access to treatment for women’s breast health, female-factor infertility, and gender affirmation to ensure that these individuals do
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14

Velu, Arunadevi, and Geetha Prasad. "Epidemiologic aspects of male infertility." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 6, no. 8 (July 26, 2017): 3362. http://dx.doi.org/10.18203/2320-1770.ijrcog20173446.

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Background: Infertility affects 10-15% of couples worldwide with rates steadily increasing in the Industrialized world, in part due to the deterioration of male reproductive health.Methods: This study was performed in an attempt to clarify the associated factors that might play a role in group of Indian infertile men. This study was a cross – sectional descriptive study conducted in Karpaga Vinayaga Institute of Medical Sciences. The information was obtained from the men who had attended the clinic from January 2016-January 2017. The factors that were studied in this research are the demograph
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15

Witczak, Bartosz, Justyna E. Klusek, and Jolanta Klusek. "Genetic aspects of male infertility." Medical Studies 4 (2014): 276–79. http://dx.doi.org/10.5114/ms.2014.47928.

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16

Pasqualotto, Fábio Firmbach, Cristhiany Victor Locambo, Kelly Silveira Athayde, and Sami Arap. "Measuring male infertility: epidemiological aspects." Revista do Hospital das Clínicas 58, no. 3 (2003): 173–78. http://dx.doi.org/10.1590/s0041-87812003000300008.

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Evidence suggests that human semen quality may have been deteriorating in recent years. Most of the evidence is retrospective, based on analysis of data sets collected for other purposes. Measures of male infertility are needed if we want to monitor the biological capacity for males to reproduce over time or between different populations. We also need these measures in analytical epidemiology if we want to identify risk indicators, risk factors, or even causes of an impaired male fecundity-that is, the male component in the biological ability to reproduce. The most direct evaluation of fecundi
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17

Kedem, Peri, Mario Mikulincer, Yvonne E. Nathanson, and Benjamin Bartoov. "Psychological aspects of male infertility." British Journal of Medical Psychology 63, no. 1 (March 1990): 73–80. http://dx.doi.org/10.1111/j.2044-8341.1990.tb02858.x.

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18

McLaughlin, Kevin, and J. White. "Surgical Aspects of Male Infertility." Seminars in Reproductive Medicine 9, no. 02 (May 1991): 156–61. http://dx.doi.org/10.1055/s-2007-1019405.

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19

Akopova, R. A., and T. V. Kokoreva. "ENDOCRINE ASPECTS OF MALE INFERTILITY." Bulletin "Biomedicine and sociology" 3, no. 4 (December 30, 2018): 17–19. http://dx.doi.org/10.26787/nydha-2618-8783-2018-3-4-17-19.

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20

Namiki, Mikio. "Genetic Aspects of Male Infertility." World Journal of Surgery 24, no. 10 (October 2000): 1176–79. http://dx.doi.org/10.1007/s002680010198.

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21

Kopa, Zsolt, and Ida Johnson. "Immune aspects of male infertility." Journal of Reproductive Immunology 101-102 (March 2014): 26. http://dx.doi.org/10.1016/j.jri.2013.12.091.

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22

Pichugova, S. V., J. G. Lagereva, I. V. Rybina, S. V. Belyaeva, L. G. Tulakina, and Ya B. Beykin. "Immuno-Endocrine Aspects of Male Infertility." Journal of Ural Medical Academic Science 14, no. 2 (2016): 102–25. http://dx.doi.org/10.22138/2500-0918-2016-14-2-102-125.

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23

Pavlov, V. N., E. F. Galimova, B. F. Teregulov, V. T. Kaybishev, and Sh N. Galimov. "MOLECULAR AND METABOLIC ASPECTS OF MALE INFERTILITY." Herald Urology, no. 2 (June 20, 2016): 40–59. http://dx.doi.org/10.21886/2308-6424-2016-0-2-40-59.

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24

Joja, O. D., D. Dinu, and D. Paun. "Psychological Aspects of Male Infertility. An Overview." Procedia - Social and Behavioral Sciences 187 (May 2015): 359–63. http://dx.doi.org/10.1016/j.sbspro.2015.03.067.

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KRAUSE, Walter. "Ralph deVere White: Aspects of Male Infertility." Andrologia 15, no. 4 (April 24, 2009): 373. http://dx.doi.org/10.1111/j.1439-0272.1983.tb00155.x.

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26

Gil'manov, A. A., G. Z. Akhmetzyanova, A. N. Khisamutdinov, S. R. Shakirzyanova, and K. R. Shakirzyanova. "Social aspects of prevention of male and female infertility." Kazan medical journal 100, no. 6 (December 9, 2019): 970–74. http://dx.doi.org/10.17816/kmj2019-970.

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Aim. To evaluate the degree of awareness of the managable social risk factors for prevention of male and female infertility and to suggest preventive measures.
 Methods. We conducted a survey among 140 medical students and 140 students of other higher educational institutions. The majority of students in both groups who participated in the survey were aged 21 to 23 years (60%). There were 20 questions in the questionnaire. They were of the following type: Do you know that ... can lead to infertility? Instead of the dots there were certain risk factors. Students answered the question yes o
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Perheentupa, Antti. "Male infertility and environmental factors." Global Reproductive Health 4, no. 2 (2019): e28. http://dx.doi.org/10.1097/grh.0000000000000028.

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28

Gracia, C. R., M. D. Sammel, C. Coutifaris, D. S. Guzick, and K. T. Barnhart. "Environmental exposures and male infertility." Fertility and Sterility 82 (September 2004): S177. http://dx.doi.org/10.1016/j.fertnstert.2004.07.463.

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Sharpe, R. M. "Environmental estrogens and male infertility." Pure and Applied Chemistry 70, no. 9 (September 1, 1998): 1685–701. http://dx.doi.org/10.1351/pac199870091685.

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30

Byun, J., C. W. Bak, J. H. Lee, Y. J. Ju, S. Han, H. H. Seok, S. W. Lyu, et al. "SESSION 33: MALE INFERTILITY - CLINICAL AND LABORATORY ASPECTS." Human Reproduction 27, suppl 2 (January 1, 2012): ii47—ii49. http://dx.doi.org/10.1093/humrep/27.s2.32.

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31

Boiko, O. V., A. A. Nikolaev, and N. I. Gydinskaya. "Microbiological aspects of male infertility pathogenesis (a review)." Problemy reproduktsii 23, no. 1 (2017): 84. http://dx.doi.org/10.17116/repro201723184-89.

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32

Phelps, Jerry. "Headliners: Male Infertility." Environmental Health Perspectives 111, no. 12 (September 1, 2003): a639. http://dx.doi.org/10.1289/ehp.111-a639.

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33

Al-Omary, Hanan L., Zainab M. Alawa, and IsraaF jaafar. "Environmental Lead Exposure and Male Infertility." IOSR Journal of Dental and Medical Sciences 15, no. 09 (September 2016): 49–54. http://dx.doi.org/10.9790/0853-1509044954.

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34

Wilcox, Allen J., and Jens Peter E. Bonde. "On environmental threats to male infertility." Asian Journal of Andrology 15, no. 2 (January 21, 2013): 199–200. http://dx.doi.org/10.1038/aja.2012.153.

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35

Szkodziak, Filip, Jarosław Krzyżanowski, and Piotr Szkodziak. "Psychological aspects of infertility. A systematic review." Journal of International Medical Research 48, no. 6 (June 2020): 030006052093240. http://dx.doi.org/10.1177/0300060520932403.

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Objective Fertility may be defined as a capacity to conceive and produce offspring. Infertility is characterized by failure to establish a clinical pregnancy after 12 months of regular and unprotected sexual intercourse. Infertility concerns an estimated 8–12% of the global population, and is associated with factors including time of unwanted non-conception, age of female partner and number of diseases impacting fertility. Unexplained infertility is described as idiopathic. This study aimed to analyse and evaluate the influence of mental disorders, often considered as reasons for idiopathic in
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Cinar, C., C. Beyazyurek, G. Ozgon, S. Ozkan, B. Ismailoglu, O. Oner, F. Fiorentino, and S. Kahraman. "4.002 Genetic aspects of male infertility in assisted reproduction." Reproductive BioMedicine Online 16 (January 2008): s38. http://dx.doi.org/10.1016/s1472-6483(10)61385-5.

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Madsen, Svend Aage, Alice T. Mikkelsen, Lisbeth Ohrt, Lise Dessing, and Peter Humaidan. "Men in ICSI treatment - Psychological aspects of male infertility." Journal of Men's Health 7, no. 3 (October 2010): 300. http://dx.doi.org/10.1016/j.jomh.2010.09.062.

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38

Baluch, Bahman, Mariam Nasseri, and Malek Mansour Aghssa. "Psychological and social aspects of male infertility in a male dominated society." Journal of Social and Evolutionary Systems 21, no. 1 (January 1998): 113–20. http://dx.doi.org/10.1016/s1061-7361(99)80007-1.

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39

HOUSTON, Brendan J., and Moira K. O’BRYAN. "Genetics of Male Infertility." Fertility & Reproduction 04, no. 03n04 (September 2022): 103. http://dx.doi.org/10.1142/s2661318222740152.

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Background: Male infertility is a common condition that affects at least 7% of men in Western countries and is associated with an elevated risk of comorbidities and mortality. While genetics is predicted to play a role in a significant percentage of cases, the aetiology of male infertility remains largely unknown. In light of this, the International Male Infertility Genomics Consortium (IMIGC) was founded, with the goals of recruiting large cohorts of infertile men, use next generation sequencing to identify high-confidence genetic causes of their infertility, and validate these genetic causes
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Dutta, Sulagna, Pallav Sengupta, Sanghamitra Das, Petr Slama, and Shubhadeep Roychoudhury. "Reactive Nitrogen Species and Male Reproduction: Physiological and Pathological Aspects." International Journal of Molecular Sciences 23, no. 18 (September 12, 2022): 10574. http://dx.doi.org/10.3390/ijms231810574.

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Reactive nitrogen species (RNS), like reactive oxygen species (ROS), are useful for sustaining reproductive processes such as cell signaling, the regulation of hormonal biosynthesis, sperm capacitation, hyperactivation, and acrosome reaction. However, endogenous levels of RNS beyond physiological limits can impair fertility by disrupting testicular functions, reducing gonadotropin production, and compromising semen quality. Excessive RNS levels cause a variety of abnormalities in germ cells and gametes, particularly in the membranes and deoxyribonucleic acid (DNA), and severely impair the matu
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Yong, EL, Q. Wang, TG Tut, FJ Ghadessy, and SC Ng. "Male infertility and the androgen receptor: molecular, clinical and therapeutic aspects." Reproductive Medicine Review 6, no. 2 (July 1997): 113–31. http://dx.doi.org/10.1017/s0962279900001459.

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Idiopathic male infertility has previously been diagnosed imprecisely, and has been treated using regimes that are not based on a clear understanding of the underlying pathophysiology; however, this is gradually changing, and a more rational approach is being adopted. Testosterone and its metabolite, DHT, is allimportant for the maintenance of sperm production and this has led us to examine the AR for causes of male infertility. Some, but not all, androgen-binding studies have indicated that in a certain proportion of cases of male infertility, defective androgen binding occurs. The cloning of
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Marić, Tihana, Aleksandra Fučić, and Anna Aghayanian. "Environmental and occupational exposures associated with male infertility." Archives of Industrial Hygiene and Toxicology 72, no. 3 (June 1, 2021): 101–13. http://dx.doi.org/10.2478/aiht-2021-72-3510.

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Abstract The upsurge in male infertility over the last two decades, possibly due to environmental exposure, has raised significant interest, particularly boosted by reports from fertility clinics, which showed that chronic diseases and hereditary or other medical conditions might only partially explain current incidence of male infertility. Both environmental and occupational settings may have a significant role in exposure to complex mixtures of endocrine disruptors (ED), which play a major role in fertility disorders. The aim of this review is to give an insight into the current knowledge on
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Sharpe, R. M. "Lifestyle and environmental contribution to male infertility." British Medical Bulletin 56, no. 3 (January 1, 2000): 630–42. http://dx.doi.org/10.1258/0007142001903436.

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44

Moreira, Sergio G., and Larry I. Lipshultz. "Management of Male Infertility." Scientific World JOURNAL 4 (2004): 214–48. http://dx.doi.org/10.1100/tsw.2004.71.

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Ibishev, Kh S., E. A. Mamedov, and H. A. Magomedov. "The immunological aspects of male infertility: 2016 - 2020 literature review." Urology Herald 8, no. 3 (October 4, 2020): 97–102. http://dx.doi.org/10.21886/2308-6424-2020-8-3-97-102.

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46

Evenson, Donald P., and Regina Wixon. "Clinical aspects of sperm DNA fragmentation detection and male infertility." Theriogenology 65, no. 5 (March 2006): 979–91. http://dx.doi.org/10.1016/j.theriogenology.2005.09.011.

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Petrella, Carla, Matteo Spaziani, Valerio D’Orazi, Luigi Tarani, Sergio Terracina, Francesca Tarani, Ginevra Micangeli, et al. "Prokineticin 2/PROK2 and Male Infertility." Biomedicines 10, no. 10 (September 25, 2022): 2389. http://dx.doi.org/10.3390/biomedicines10102389.

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Male infertility represents about 50% of the causes of infertility in couples. The diagnosis process represents an important procedure for defining, when possible, the causes and approaching treatments (pharmacological, surgical) aimed at overcoming the problem. Several scientific studies have set out to discover early and indicative markers capable of providing information on the biological origin of infertility and increase current knowledge in the context of new potential therapeutic approaches. The prokineticin system (PROK) consists of the prokineticin 1 (PROK1) and prokineticin 2 (PROK2)
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Bonde, Jens Peter Ellekilde. "Occupational risk for male infertility." Occupational and Environmental Medicine 71, no. 9 (July 21, 2014): 596–97. http://dx.doi.org/10.1136/oemed-2014-102309.

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Strohmer, Heinz, Andrea Boldizsar, Barbara Plöckinger, Michel Feldner-Busztin, and Wilfried Feichtinger. "Agricultural work and male infertility." American Journal of Industrial Medicine 24, no. 5 (November 1993): 587–92. http://dx.doi.org/10.1002/ajim.4700240508.

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Aksoy, Ahu, and Duygu Vefikuluçay Yilmaz. "Assessment of Male Infertility." International Journal of Emerging Trends in Health Sciences 3, no. 1 (June 1, 2019): 9–21. http://dx.doi.org/10.18844/ijeths.v3i1.4093.

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As a result of modern life, postponement of gestational age, obesity, electromagnetic waves, hormone and genetically modified foods, stress, smoking and alcohol use and sexually transmitted diseases directly cause negative effects on human health. The reproductive system, which is sensitive to environmental changes, is the most affected. In recent years, the usage of assisted reproductive techniques led to an increase in the number of men as well women who consults health institutions for assistance in conception. Because factors pertaining to males comprise half of all fertility problems. In
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